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CT Atlas of Adult Congenital Heart Disease

http://libcat.nshealth.ca/permalink/provcat40707
Wojciech Mazur, Marilyn J. Siegel, Tomasz Miszalski-Jamka, Robert Pelberg. Springer , c2013.
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Improvements in surgical and medical management of congenital heart disease (CHD) result in an increased life expectancy and a greater number of children living into adulthood. Consequently, adult cardiologists are caring for increasing numbers of patients with congenital heart defects. In many instances, these patients have undergone palliative but not corrective procedures and may be at higher risk of cardiovascular morbidity and mortality. In the past several years, the use of CT angiography…
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Author
Mazur, Wojciech
Other Authors
Miszalski-Jamka, Tomasz
Pelberg, Robert
Siegel, Marilyn J
Responsibility
Wojciech Mazur, Marilyn J. Siegel, Tomasz Miszalski-Jamka, Robert Pelberg
Place of Publication
London
Publisher
Springer
Date Published
c2013
Physical Description
1 online resource (xix, 367 p. : 330 illus., 125 illus. in color)
ISBN
9781447150879 (print ed.)
9781447150886
Subjects (MeSH)
Heart Defects, Congenital - diagnostic imaging
Radiography
Tomography, X-Ray Computed
Abstract
Improvements in surgical and medical management of congenital heart disease (CHD) result in an increased life expectancy and a greater number of children living into adulthood. Consequently, adult cardiologists are caring for increasing numbers of patients with congenital heart defects. In many instances, these patients have undergone palliative but not corrective procedures and may be at higher risk of cardiovascular morbidity and mortality. In the past several years, the use of CT angiography (CTA) has increased, driven mainly by technical improvements that allow shorter imaging times and high spatial and temporal resolution. Thus, CTA combines widespread availability with the advantages of volumetric data acquisition, short acquisition times, and the possibility of simultaneous evaluation of myocardial and extracardiac structures, ventricular function and coronary anatomy making it a very appealing imaging modality in CHD patients. CT Atlas of Adult Congenital Heart Disease is an all inclusive, invaluable tool to describe the features of classic CHD, hereditary cardiomyopathies and aortopathies. It includes comprehensive pathology descriptions and discussions of the utility of CTA in the diagnosis of all forms of adult CHD. The many CTA images and illustrations demonstrate the pathologies and provide a framework for recognizing patterns of CHD in adult patients. It also includes pre-procedural pediatric CHD cases to allow better understanding of CHD anatomy and pathophysiology, and thus will be essential reading for all pediatric and adult cardiologists and radiologists involved in the management of these patients.
Contents
Part I. Embyology and the Normal Heart -- Cardiac Embryology -- The Normal Heart -- Normal Anatomic Variants and Imaging Artifacts Mimicking Pathology -- Part II. Basic Nomenclature and Approach to Evaluating Congenital Heart Disease Imaging -- Basic nomenclature and Approach to Evaluating Congenital Heart Disease Imaging -- Basic Nomenclature in Adult Congenital Heart Disease -- Segmental, Sequential Approach to CT Interpretation in Adult Congenital Heart Disease -- Part III. CT Imaging Techniques in Adult Congenital Heart Disease -- Technical Principles in CT Imaging of Adult Congenital Heart Disease -- Part IV. Congenital Dysplasias and Cardiomyopathies -- Arrythmogenic Right Ventricular Dysplasia -- Uhl Anomaly -- Isolated Left Ventricular Noncompaction (LVNC) -- Hyperthrophic Cardiomiopathy -- Part V. Anomalies with Normal Chamber and Valve Sequence and Position -- Septal Defects -- Atrioventricular valve abnormalities -- Left ventricular outflow tract abnormalities -- Right ventricular outflow tract obstruction -- Arterial Anomalies -- Coronary Artery Anomalies -- Congenital Venous Anomalies -- Part VI. Anomalies with Abnormal Chamber Sequence or Relationship -- Abnormal Relationship between Atria and Ventricles -- Abnormal Relationships between Ventricles and Great Vessels -- Heterotaxy syndrome -- Part VII. Palliative and Corrective Procedures in Adult Congenital Heart Disease -- Percutaneous Closures -- Aortopulmonary Shunts: Blalock–Taussig, Potts, Waterston -- Atrial Baffles for the Treatment of Transposition of the Great Arteries (Mustard, Senning) -- Arterial Switch Operation for Transposition of the Great Arteries -- Systemic Vein to Pulmonary Artery Shunts: Glenn, Fontan, and Kawashima Procedures -- Rastelli Procedure -- Damus-Kaye-Stansel Procedure -- Double-Switch Procedure -- Tetrology of Fallot Repair -- Ross Procedure -- Norwood Procedure and Sano Modification -- Aortic Coarctation Repairs -- Part VIII. Congenital Pericardial Abnormalites -- Congenital Absence of the Pericardium.
Format
e-Book
Publication Type
Atlases
Location
Online
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Physician's Guide : Understanding and Working With Integrated Case Managers

http://libcat.nshealth.ca/permalink/provcat40110
Roger G. Kathol, Katherine Hobbs Knutson, Peter J. Dehnel. Springer , c2016.
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Improving the outcomes for patients in our changing healthcare system is not straightforward. This grounding publication on case management helps physicians better meet the unique needs of patients who present with poor health and high healthcare-related costs, i.e., health complexity. It details the many challenges and optimal practices needed to work effectively with various types of case managers to improve patient outcomes. Special attention is given to integrated case management (ICM), spe…
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Author
Kathol, Roger G
Other Authors
Dehnel, Peter J
Hobbs Knutson, Katherine
Responsibility
Roger G. Kathol, Katherine Hobbs Knutson, Peter J. Dehnel
Place of Publication
Cham
Publisher
Springer
Date Published
c2016
Physical Description
1 online resource (xv, 343 p. : 12 illus. in color)
ISBN
9783319289571 (print ed.)
9783319289595
Subjects (MeSH)
Case management
Delivery of Health Care, Integrated - methods
Outcome Assessment (Health Care) - methods
Practice Patterns, Physicians'
Other Subjects
United States
Abstract
Improving the outcomes for patients in our changing healthcare system is not straightforward. This grounding publication on case management helps physicians better meet the unique needs of patients who present with poor health and high healthcare-related costs, i.e., health complexity. It details the many challenges and optimal practices needed to work effectively with various types of case managers to improve patient outcomes. Special attention is given to integrated case management (ICM), specifically designed for those with health complexity. The book provides a systematic method for identifying and addressing the needs of patients with biological, psychological, social, and health-system related clinical and non-clinical barriers to improvement. Through ICM, case managers are trained to conduct relationship-building multidisciplinary comprehensive assessments that allow development of prioritized care plans, to systematically assist patients to achieve and document health outcomes in real time, and then graduate stabilized patients so that others can enter the case management process. Patient-centered practitioner-case manager collaboration is the goal. This reference provides a lexicon and a roadmap for physicians in working with case managers as our health system explores innovative ways to improve outcomes and reduce health costs for patients with health complexity. An invaluable, gold-standard title, it adds to the literature by capturing the authors' personal experiences as clinicians, researchers, teachers, and consultants. The Physician's Guide: Understanding and Working With Integrated Case Managers summarizes how physicians and other healthcare leadership can successfully collaborate with case managers in delivering a full package of outcome changing and cost reducing assistance to patients with chronic, treatment resistant, and multimorbid conditions.
Contents
Part I. Overview of Case Management, Health Complexity, and the Integrated Case Management Approach -- 1. Patient Health Care Assist and Support Services, Integrated Case Management, and Complexity Assessment Grids -- 2. Health Complexity and the Interaction Between Physical and Behavioral Health Conditions in Adults -- 3. Health Complexity and the Interaction Between Physical and Behavioral Health Conditions in Children and Youth -- 4. The Organizational and Operational Setup of Adult Integrated Complex Case Management -- 5. The Organizational and Operational Setup of Pediatric Integrated Complex Case Management -- 6. Indirect and Direct Physician Support for Integrated Case Management in Adults -- 7. Indirect and Direct Physician Support for Integrated Case Management in Children/Youth -- Part II. Guidelines for Physicians Working to Maximize Patient Outcomes in Collaboration with Integrated Case Managers- 8. Organizing and Implementing Value-Added Integrated Case Management -- 9. Connecting Integrated Case Management with Integrated Complex Inpatient and Outpatient Care -- 10. Physicians' Contributions to Building and Participating in a Population-Based Case Management Center of Excellence -- III. Appendices -- Appendix 1. Integrated Case Management (ICM) Algorithmic Triage Strategies -- Appendix 2. Adult Integrated Case Management-Complexity Assessment Grid (ICM-CAG) Variables and their Clinical Anchor Points -- Appendix 3. Scripted Dialogue for Adults -- Appendix 4.Elina's ICM-CAG Assessment Story -- Appendix 5. Scripted Dialogue for Children/Youth and Parents/Caregivers -- Appendix 6. Care Plan Development Sheet -- Appendix 7. Measurement of Progress: Goals, Actions, Outcomes -- Appendix 8. Pediatric Record for Outcome Measurement (ROM) -- Appendix 9. Pediatric ICM-CAG Variables and Anchors -- Appendix 10. Pediatric ICM-CAG Item Anchor Point Actions -- Appendix 11. Understanding "Complexity Assessments" for Youth and Families Helped by Case Management -- Appendix 12. Understanding “Complexity Assessments” for Clinicians with Children/Youth in Integrated Case Management -- Appendix 13. Notification Letter to Patient’s Clinician(s) -- Appendix 14. Universal Consent Form -- Appendix 15. Adult ICM-CAG Item Anchor Point Actions -- Appendix 16. Understanding “Complexity Assessments” for Persons Entering Integrated Case Management -- Appendix 17. Understanding “Complexity Assessments” for Clinicians with Patients in Integrated Case Management -- Appendix 18.: Barriers to Adherence -- Appendix 19. Adult Patient-Centered ICM Performance (PCIP) -- Appendix 20. Core ICM Principles -- Appendix 21. Core ICM Practices Needed to Implement the Full ICM Components -- Glossary of Case Management Terms -- Abbreviations.
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e-Book
Location
Online
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HCV Infection and Cryoglobulinemia

http://libcat.nshealth.ca/permalink/provcat31215
Franco Dammacco, editor. Springer , c2012.
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In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These "cryoglobulins" were responsible for the corresponding clinical condition "cryoglobulinemia." Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepati…
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Other Authors
Dammacco, Franco
Responsibility
Franco Dammacco, editor
Place of Publication
Milan
Publisher
Springer
Date Published
c2012
Physical Description
1 online resource (xvii, 360 p. : 64 ill., 52 ill. in color)
ISBN
9788847017054
Subjects (MeSH)
Cryoglobulinemia
Hepacivirus
Hepatitis C, Chronic
Vasculitis - pathology
Subjects (LCSH)
Hematology
Infectious diseases
Abstract
In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These "cryoglobulins" were responsible for the corresponding clinical condition "cryoglobulinemia." Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepatitis C virus infection. The book is unique in its detailed presentation and fundamental approach. Highly qualified authors have contributed critical articles reviewing significant developments in our understanding of and therapeutic approach to HCV infection and cryoglobulinemia. The text is accompanied by striking color images and illustrations and highly informative tables. This comprehensive review of a systemic disease with a complex etiology is a valuable source of up-to-date, expert information not only for basic scientists and specialists in several disciplines but also for general practitioners as well as graduate and post-graduate students in clinical and medical research.
Contents
[Machine generated contents note] 1. Introductory Remarks / Domenico Sansonno -- Pt. I. Hepatitis C Virus Infection and the Role of the Immune System -- 2. Natural History, Pathogenesis, and Prevention of HCV Infection / Charles M. Rice -- 3. Immune Control of HCV Infection / Lynn B. Dustin -- 4. B Cell Activation: General to HCV-Specific Considerations / Claudia Brunetti -- 5. Organ-Specific Autoimmunity in HCV-Positive Patients / Fabio Presotto -- Pt. II. Cellular Compartments of HCV Infection (and Replication) -- 6. HCV and Blood Cells: How Can We Distinguish Infection from Association? / Charles M. Rice -- 7. Mechanisms of Cell Entry of Hepatitis C Virus / Vito Racanelli -- 8. HCV Infection of Hematopoietic and Immune Cell Subsets / Tomasz I. Michalak -- Pt. III. Cryoglobulinemia and the Complement System -- 9. Cryoglobulinemia and Chronic HCV Infection: An Evolving Story / Marten Trendelenburg -- 10. Complement System in Cryoglobulinemia / Marten Trendelenburg -- 11. Pivotal Role of C1qR in Mixed Cryoglobulinemia / Franco Dammacco -- Pt. IV. Structural and Genetic Features, Cytokines and Chemokines in Cryoglobulinemia -- 12. Mixed Cryoglobulinemia (MC) Cross-Reactive Idiotypes (CRI): Structural and Clinical Significance / Peter D. Gorevic -- 13. Molecular Insights into the Disease Mechanisms of Type II Mixed Cryoglobulinemia / Marica Garziera -- 14. Role of VCAM-1 in the Pathogenesis of Hepatitis-C-Associated Mixed Cryoglobulinemia Vasculitis / Gilles Kaplanski -- 15. Up-Regulation of B-Lymphocyte Stimulator (BLyS) in Patients with Mixed Cryoglobulinemia / Salvatore De Vita -- 16. Role of B-Cell-Attracting Chemokine-1 in HCV-Related Cryoglobulinemic Vasculitis / Franco Dammacco -- 17. Serum a-Chemokine CXCL10 and ß-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia / Poupak Fallahi -- Pt. V. Clinical Manifestations of Cryoglobulinemia -- 18. Experimental Models of Mixed Cryoglobulinemia / Kelly L. Hudkins -- 19. Expanding Spectrum of Clinical Features in HCV-Related Mixed Cryoglobulinemia / Anna Linda Zignego -- 20. Classification of Cryoglobulinemic Vasculitis / Luca Quartuccio -- 21. Demographic and Survival Studies of Cryoglobulinemic Patients / Laura Castelnovo -- 22. HCV-Associated Membranoproliferative Glomerulonephritis / John Prentiss Johnson -- 23. Rheumatologic Symptoms in Patients with Mixed Cryoglobulinemia / Elisa Gremese -- 24. Endocrine Manifestations of HCV-Positive Cryoglobulinemia / Poupak Fallahi -- 25. Cutaneous Cryoglobulinemic Vasculitis / J. Andrew Carlson -- 26. Peripheral Neuropathy and Central Nervous System Involvement in Cryoglobulinemia / Sergio Ferrari -- 27. Long-Term Course of Patients with Mixed Cryoglobulinemia / Patrice P. Cacoub -- 28. HBV/HCV Co-infection and Mixed Cryoglobulinemia / Salvatore Sollima -- 29. Clinical and Immunological Features of HCV/HIV Co-infected Patients with Mixed Cryoglobulinemia / Patrice P. Cacoub -- 30. HCV-Negative Mixed Cryoglobulinemia: Facts and Fancies / Giuseppe Monti -- 31. Cryoglobulinemia in HCV-Positive Renal Transplant and Liver Transplant Patients / Nassim Kamar -- Pt. VI. HCV Infection, Cryoglobulinemia and Non-Hodgkin’s Lymphomas -- 32. Chromosome Abnormalities in HCV-Related Lymphoproliferation / Caterina Matteucci -- 33. Molecular Features of Lymphoproliferation in Mixed Cryoglobulinemia / Maria Paola Simula -- 34. Higher Prevalence of B-Cell Non-Hodgkin’s Lymphoma in HCV-Positive Patients with and Without Cryoglobulinemia / Domenico Sansonno -- 35. Incidence and Characteristics of Non-Hodgkin’s Lymphomas in HCV-Positive Patients with Mixed Cryoglobulinemia / Pietro Enrico Pioltelli -- 36. Waldenstrom’s Macroglobulinemia Associated with Cryoglobulinemia: Pathogenetic, Clinical, and Therapeutic Aspects / Efstathios Kastritis -- Pt. VII. Therapy of Cryoglobulinemia -- 37. Should HCV-Positive Asymptomatic Patients with Mixed Cryoglobulinemia Be Treated with Combined Antiviral Therapy? / Fernando Pons Renedo -- 38. Role of Rituximab in the Therapy of Mixed Cryoglobulinemia / Renato Fanin -- 39. Rituximab in Cryoglobulinemic Vasculitis: First- or Second-Line Therapy? / Paul Klenerman -- 40. PIRR Therapy in HCV-Related Mixed Cryoglobulinemia / Domenico Sansonno -- 41. Antiviral Therapy in HCV-Positive Non-Hodgkin’s Lymphoma: Pathogenetic Implications / Domenico Sansonno -- 42. Active or Indolent Cutaneous Ulcers in Cryoglobulinemia: How Should They Be Treated? / Maurizio Pietrogrande -- 43. Double Filtration Plasmapheresis: An Effective Treatment of Cryoglobulinemia / Paola Brescia -- 44. Emergency in Cryoglobulinemia: Clinical and Therapeutic Approach / Giuseppe Monti -- 45. Novel Therapeutic Approaches to Cryoglobulinemia: Imatinib, Infliximab, Bortezomib, and Beyond / Maurizio Zangari.
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e-Book
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Online
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Contrast media : safety issues and ESUR guidelines

http://libcat.nshealth.ca/permalink/provcat33251
Henrik S. Thomsen, Judith A. W. Webb, editors. (Third edition) Springer , c2014.
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In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned ESUR members, reviewed the literature, proposed guidelines, and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006, which was followed by an equally successful second edition in 2009. Thi…
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Other Authors
Thomsen, Henrik S
Webb, Judith A. W
Responsibility
Henrik S. Thomsen, Judith A. W. Webb, editors
Edition
Third edition
Place of Publication
Heidelberg
Publisher
Springer
Date Published
c2014
Physical Description
1 online resource (xvi, 280 pages)
Series
Medical radiology. Diagnostic imaging
Series Title
Medical radiology (Series)
ISBN
9783642367236
9783642367243 (electronic bk.)
Subjects (MeSH)
Contrast Media - adverse effects
Extravasation of Diagnostic and Therapeutic Materials
Safety Management - standards - Europe
Subjects (LCSH)
Genitourinary organs - Imaging - Safety measures - Standards - Europe
Radiographic contrast media - Safety measures
Radiographic contrast media - Toxicology
Notes
Previous edition: 2009
Abstract
In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned ESUR members, reviewed the literature, proposed guidelines, and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006, which was followed by an equally successful second edition in 2009. This third edition not only fully updates the previous edition, but also includes new chapters on complex topics such as use of contrast media in children and practical aspects of off-label contrast media use. The authorship includes members, past members, and non-members of the Contrast Media Safety Committee. Comprehensive consideration is given to the many different safety issues relating to iodine-based contrast media, gadolinium-based contrast media, microbubbles for ultrasound, and barium sulfate. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All of the questions frequently raised in radiological practice are addressed. This book, presented in a handy, easy-to-use format, provides an invaluable, unique, and unparalleled source of information.
Contents
General Issues: Classification and Terminology -- Requests for Imaging using contrast agents: What information must be provided -- Off-label use of medicines: legal aspects -- Off-label use of contrast media: practical aspects -- Pharmacovigilance: When to report adverse reactions to contrast media -- What is required to get the authorities to approve a new contrast medium? -- A critical review of meta-analysis of adverse events after contrast media -- Iodine- and Gadolinium-Based Contrast Media: General Adverse Reactions: Acute adverse reactions to contrast media: Mechanisms and prevention -- Iodine-based contrast medium temperature and adverse reactions -- Management of acute adverse reactions to contrast media -- Renal Adverse reactions:Chronic kidney disease, serum creatinine and estimated glomerular filtration rate (eGFR) -- Contrast medium-induced nephropathy -- Dialysis and contrast media -- Other adverse effects: Pregnancy and lactation: intravascular use of contrast media -- Pheochromocytoma and contrast media -- Contrast media and interactions with other drugs and clinical tests -- Contrast media extravasation injury -- Iodine-based contrast media: Late adverse reactions to iodine-based contrast media -- Effects of iodine-based contrast media on blood and endothelium -- Effects of iodine-based contrast media on thyroid function -- Pulmonary effects of iodine-based contrast media -- MR contrast media: Gadolinium chelates and stability -- Diagnostic efficacy of gadolinium-based contrast media -- Radiography with gadolinium-based contrast media -- Acute adverse reactions to gadolinium-based contrast media -- Nephrogenic systemic fibrosis and gadolinium- based contrast media -- Organ specific gadolinium-based contrast media -- Ultrasonographic Contrast media -- Barium Preparations: Barium preparations: safety issues -- Pediatric use of Contrast Media: Contrast media use in pediatrics: Safety issues -- Appendix: ESUR Guidelines on Contrast Media Version 8.1 -- Official publications from the Contrast Media Safety Committee of the European Society of Urogenital Radiology.
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e-Book
Location
Online
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Individualized Medicine : Ethical, Economical and Historical Perspectives

http://libcat.nshealth.ca/permalink/provcat39130
Tobias Fischer, Martin Langanke, Paul Marschall, Susanne Michl, editors. Springer , c2015.
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In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes--next to clinical examples illustrating how the integrated analysis of …
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Other Authors
Fischer, Tobias
Langanke, Martin
Marschall, Paul
Michl, Susanne
Responsibility
Tobias Fischer, Martin Langanke, Paul Marschall, Susanne Michl, editors
Place of Publication
Cham
Publisher
Springer
Date Published
c2015
Physical Description
1 online resource (xvi, 323 p. : 24 illus., 18 illus. in color)
Series Vol.
v. 7
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9783319117188 (print ed.)
9783319117195
ISSN
2211-3495
Subjects (MeSH)
Precision Medicine
Abstract
In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes--next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients--chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.
Contents
1. Introduction -- Part I. Definition and Concept of Individualized Medicine -- 2. The Meaning of “Individualized Medicine”: A Terminological Adjustment of a Perplexing Term -- 3. Individualized Medicine Within the GANI_MED Project -- Part II. Perspectives of Socio-Cultural and Historical Studies 4. Inventing Traditions, Raising Expectations. Recent Debates on “Personalized Medicine" -- 5. The Epistemics of “Personalized Medicine”. Rebranding Pharmacogenetics -- Part III. Medical Perspectives -- 6. Use of Biomarkers for the Prediction of Treatment Response: Immunoadsorption in Dilated Cardiomyopathy as a Clinical Example -- 7. The Role of Pharmacogenomics in Individualized Medicine -- Part IV. Concept-Based Ethical Questions -- 8. On a Philosophy of Individualized Medicine: Conceptual and Ethical Questions -- 9. The Concept of Disease in the Era of Prediction -- Part V. Applied Research Ethics -- 10. Informed Consent in GANI_MED—A Sectional Design for Clinical Epidemiological Studies Within Individualized Medicine -- 11. Ethics Meets IT: Aspects and Elements of Computer-based Informed Consent Processing -- 12. Handling Incidental Findings from Imaging Within IM Related Research—Results from an Empirical-Ethical Study -- Part VI. Health Economic Assessment of Individualized Medicine -- 13 Individualized Medicine: From Potential to Macro-Innovation -- 14. Assessing Individualized Medicine—The Example of Immunoadsorption -- 15. How Individualized is Medicine Today? -- 16. Conclusions and Recommendations.
Format
e-Book
Location
Online
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Surgical Oncology Manual

http://libcat.nshealth.ca/permalink/provcat39999
Frances C. Wright, Jaime Escallon, Moises Cukier, Melanie E. Tsang, Usmaan Hameed, editors. (2nd ed.) Springer , c2016.
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In 2011, the General Surgical Oncology Fellowship Program at the University of Toronto sought to develop a practical approach to common oncology problems faced by general surgeons in a collaboration between current and previous fellows, as well as staff at the University of Toronto, including experts from Princess Margaret Cancer Centre, Odette Cancer Centre (at Sunnybrook Health Sciences Centre), Mount Sinai Hospital, Toronto General Hospital, St. Michael's Hospital, and St. Joseph's Hospital.…
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Other Authors
Cukier, Moises
Escallon, Jaime
Hameed, Usmaan
Tsang, Melanie E
Wright, Frances C
Responsibility
Frances C. Wright, Jaime Escallon, Moises Cukier, Melanie E. Tsang, Usmaan Hameed, editors
Edition
2nd ed.
Place of Publication
Cham
Publisher
Springer
Date Published
c2016
Physical Description
1 online resource (xv, 341 p. : 4 illus., 2 illus. in color)
ISBN
9783319262741 (print ed.)
9783319262765
Subjects (MeSH)
Neoplasms - surgery
Notes
Originally published by the Department of Surgery, University of Toronto, Canada, March 25, 2013.
Abstract
In 2011, the General Surgical Oncology Fellowship Program at the University of Toronto sought to develop a practical approach to common oncology problems faced by general surgeons in a collaboration between current and previous fellows, as well as staff at the University of Toronto, including experts from Princess Margaret Cancer Centre, Odette Cancer Centre (at Sunnybrook Health Sciences Centre), Mount Sinai Hospital, Toronto General Hospital, St. Michael's Hospital, and St. Joseph's Hospital. This effort culminated in the publication of the Surgical Oncology Manual in March, 2012. The first edition received excellent feedback on its utility from both trainees and practicing surgeons alike. With the ever-changing landscape of surgical oncology, this edition is updated with new evidence and topics in the field, providing a succinct review of surgical oncology with a summary of key evidence in the work-up, treatment, and follow-up for each cancer site as well as a section of "Pearls", derived from the wide breadth of experience, skills, and abilities of the contributors. A clear, concise format has proven invaluable to the intended audience: surgical oncology fellows, practicing general surgeons, general surgery residents, and medical students.
Contents
1. Tumours of the Adrenal Gland -- 2. Ampullary Cancer -- 3. Anal Cancer -- 4. Breast Cancer -- 5. Cholangiocarcinoma -- 6. Colon Cancer -- 7. Colorectal Liver Metastases -- 8. Gallbladder Cancer -- 9. Desmoid Fibromatosis and Dermatofibrosarcoma Protuberans -- 10. Gastric Adenocarcinoma -- 11. Gastrointestinal Stromal Tumours -- 12. Hepatocellular Carcinoma -- 13. Melanoma -- 14. Merkel Cell Carcinoma -- 15. Multidisciplinary Cancer Conferences -- 16. Neuroendocrine Tumours (GastroEnteroPancreatic) -- 17. Non-melanoma Skin Cancer -- 18. Palliative Surgical Care -- 19. Adenocarcinoma of the Pancreas -- 20. Peritoneal Surface Malignancies -- 21. Rectal Cancer -- 22. Retroperitoneal and Extremity Soft Tissue Sarcomas -- 23. Thyroid Cancer.
Format
e-Book
Publication Type
Handbooks
Location
Online
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Making the DSM-5 : Concepts and Controversies

http://libcat.nshealth.ca/permalink/provcat40723
Joel Paris, James Phillips, editors. Springer , c2013.
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In 2013, the American Psychiatric Association published the 5th edition of its Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Often referred to as the "bible" of psychiatry, the manual only classifies mental disorders and does not explain them or guide their treatment. While science should be the basis of any diagnostic system, to date, there is no knowledge on whether most conditions listed in the manual are true diseases. Moreover, in DSM-5 the overall definition of mental dis…
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Other Authors
Paris, Joel
Phillips, James
Responsibility
Joel Paris, James Phillips, editors
Place of Publication
New York, NY
Publisher
Springer
Date Published
c2013
Physical Description
1 online resource (ix, 180 p. : ill.)
ISBN
9781461465034 (print ed.)
9781461465041
Subjects (MeSH)
Diagnostic and Statistical Manual of Mental Disorders. 5th ed.
Mental Disorders - classification
Abstract
In 2013, the American Psychiatric Association published the 5th edition of its Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Often referred to as the "bible" of psychiatry, the manual only classifies mental disorders and does not explain them or guide their treatment. While science should be the basis of any diagnostic system, to date, there is no knowledge on whether most conditions listed in the manual are true diseases. Moreover, in DSM-5 the overall definition of mental disorder is weak, failing to distinguish psychopathology from normality. In spite of all the progress that has been made in neuroscience over the last few decades, the psychiatric community is no closer to understanding the etiology and pathogenesis of mental disorders than it was fifty years ago. In Making the DSM-5, prominent experts delve into the debate about psychiatric nosology and examine the conceptual and pragmatic issues underlying the new manual. While retracing the historic controversy over DSM, considering the political context and economic impact of the manual, and focusing on what was revised or left unchanged in the new edition, this timely volume addresses the main concerns of the future of psychiatry and questions whether the DSM legacy can truly improve the specialty and advance its goals.
Contents
Part I. Historical/Ideological Perspectives -- The History of DSM -- Considering the Economy of DSM Alternatives -- The Ideology behind DSM-5 -- Part II. Ideological and Conceptual Perspectives -- The Biopolitics of Defining "Mental Disorder" -- Establishing Normative Validity for Scientific Psychiatric Nosology: The Significance of Integrating Patient Perspectives -- The Paradox of Professional Success: Grand Ambition, Furious Resistance, and the Derailment of the DSM-5 Revision -- Part III. Conceptual Perspectives -- DSM in Philosophyland: Curiouser and Curiouser -- Overdiagnosis, Underdiagnosis, Synthesis: A Dialectic for Psychiatry and the DSM -- What does Phenomenology Contribute to the Debate about DSM-5 -- The Conceptual Status of DSM-5 Diagnoses -- Conclusion.
Format
e-Book
Location
Online
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A Case-Based Guide to Clinical Endocrinology

http://libcat.nshealth.ca/permalink/provcat39002
Terry F. Davies, editor. (Second edition) Springer , c2015.
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In A Case-Based Guide to Clinical Endocrinology, Second Edition, a renowned group of distinguished clinicians once again provides stimulating instruction and insights into a wide variety of endocrine topics, teaching readers modern management of the conditions described andáoffering targeted entry into the literature. Importantly, many of the important elements in the current curriculum for clinical endocrine training as recommended by the Association of Program Directors in Clinical Endocrinol…
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Other Authors
Davies, Terry F
Responsibility
Terry F. Davies, editor
Edition
Second edition
Place of Publication
New York, NY
Publisher
Springer
Date Published
c2015
Physical Description
1 online resource (xvii, 453 p. : 31 illus., 18 illus. in color)
ISBN
9781493920587 (print ed.)
9781493920594
Subjects (MeSH)
Endocrine System - pathology
Endocrine System Diseases
Abstract
In A Case-Based Guide to Clinical Endocrinology, Second Edition, a renowned group of distinguished clinicians once again provides stimulating instruction and insights into a wide variety of endocrine topics, teaching readers modern management of the conditions described andáoffering targeted entry into the literature. Importantly, many of the important elements in the current curriculum for clinical endocrine training as recommended by the Association of Program Directors in Clinical Endocrinology, Diabetes and Metabolism are covered in this text. Thoroughly updated, this new edition not only covers new treatment approaches but also emphasizes the latest investigative advances in both imaging and molecular diagnostics. To reinforce learning and retention of knowledge, a question-based approach is used in many of the case studies. Students, residents, fellows, and practitioners will find this reference to be an efficient way to review their understanding and increase their skills and abilities in patient investigation and management. An invaluable contribution to the field, A Case-Based Guide to Clinical Endocrinology, Second Edition, offers the same comprehensive volume of thought-provoking case-studies that made the first edition of significant importance to all clinicians who treat patients with endocrine disorders.
Contents
Part I. Pituitary -- 1 Introduction -- 2 Acromegaly, Awareness Is Paramount for Early Diagnosis: Highlights of Diagnosis and Treatment Challenges -- 3 A Nontraumatic Hip Fracture in a Young Woman: Cushing’s Disease—Consequences of a Late Diagnosis and Treatment Highlights -- 4 Idiopathic Granulomatous Hypophysitis Masquerading as a Pituitary Adenoma: Are There Reliable Diagnostic Criteria? -- Part II. Thyroid Overactivity -- 5 Introduction -- 6 TSH-Secreting Pituitary Adenoma -- 7 Struma Ovarii -- 8 Exogenous Thyrotoxicosis -- Part III. Thyroid Underactivity -- 9 Introduction -- 10 Central Hypothyroidism -- 11 Treatment of Hypothyroidism: Utility of Adding T3 (Liothyronine) -- 12 Hypothyroidism in Pregnancy -- 13 Hypothyroid Myopathy and Thelogen Effluvium -- Part IV. Thyroid Cancer -- 14 Introduction -- 15 Approach to the Patient with an Incidentally Discovered Thyroid Nodule -- 16 Papillary Thyroid Cancer -- 17 Metastatic Papillary Thyroid Cancer -- 18 Management of Metastatic Medullary Thyroid Cancer -- 19 Thyroid Cancer and Bone Metastases -- Part V. Adrenal -- 20 Introduction -- 21 Primary Aldosteronism -- 22 Adrenal Incidentaloma and Subclinical Hypercortisolism -- 23 A Case of Pheochromocytoma -- Part VI. Hyperparathyroidism -- 24 Introduction -- 25 Complex Primary Hyperparathyroidism -- 26 Differential Diagnosis of Hypocalcemia - 27 Management of Hypoparathyroidism -- 28 Osteomalacia and Primary Hyperparathyroidism -- Part VII. Metabolic Bone Diseases -- 29 Introduction -- 30 Multiple Risk Factors for Osteoporosis and Fracture -- 31 Delayed Diagnosis of Osteoporosis -- 32 Misdiagnosis of Atypical Femur Fractures -- Part VIII. Endocrine Disorders of Men -- 33 Introduction -- 34 Congenital Hypogonadotropic Hypogonadism -- 35 Klinefelter Syndrome -- 36 Low Testosterone and the Metabolic Syndrome -- Part IX. Pregnancy -- 37 Introduction -- 38 Getting Pregnant with PCOS -- 39 Thyrotoxicosis in Pregnancy -- 40 Gestational Diabetes -- Part X. Diabetes -- 41 Introduction: Type-2 Diabetes -- 42 Evaluation and Management of the Newly Diagnosed Patient with Type-2 Diabetes -- 43 Transition to Insulin in Patients with Type-2 Diabetes -- 44 Inpatient Management of Type 2 Diabetes -- Part XI. Lipid Abnormalities -- 45 Introduction -- 46 LDL-Apheresis Therapy for Refractory Familial Hypercholesterolemia -- 47 Familial Type III Hyperlipoproteinemia (Familial Dysbetalipoproteinemia) -- 48 Severe Hypertriglyceridemia -- Part XII. Obesity -- 49 Introduction -- 50 Metabolic Syndrome Case -- 51 The Polycystic Ovarian Syndrome (PCOS) -- 52 Bariatric Surgery.
Format
e-Book
Publication Type
Case Reports
Location
Online
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Handbook of Practical Immunohistochemistry : Frequently Asked Questions

http://libcat.nshealth.ca/permalink/provcat38960
Fan Lin, Jeffrey Prichard, editors. (Second edition) Springer , c2015.
Available Online
View e-Book
Location
Online
In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue micr…
Available Online
View e-Book
Other Authors
Lin, Fan
Prichard, Jeffrey
Responsibility
Fan Lin, Jeffrey Prichard, editors
Edition
Second edition
Place of Publication
New York, NY
Publisher
Springer
Date Published
c2015
Physical Description
1 online resource (xv, 764 p. : 465 illus., 461 illus. in color)
ISBN
9781493915774 (print ed.)
9781493915781
Subjects (MeSH)
Immunohistochemistry - methods
Abstract
In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
Contents
Immunohistochemistry Quality Management and Regulation -- Standardization of Diagnostic Immunohistochemistry -- Automated Immunohistochemistry Overview -- Geisinger Immunohistochemical Antibodies and Staining Protocols -- Immunohistochemistry: A Dako Perspective -- Immunohistochemistry: Ventana Perspective -- Rabbit Monoclonal Antibodies -- Immunohistochemical Detection of Phosphoproteins and Cancer Pathways -- Overview of Predictive Biomarkers and Integration of IHC into Molecular Pathology -- Tissue Microarray -- Unknown Primary/Undifferentiated Neoplasm -- Exfoliative Cytology and Effusions -- Breast -- Predictive Biomarkers in Breast Cancer: ER, PR and Her-2/neu -- Central Nerve System -- Thyroid, Parathyroid and Adrenal Glands -- Salivary Glands and Head and Neck -- Pleuropulmonary and Mediastinal Neoplasms -- Uterus -- Ovary -- Prostate Gland -- Urinary Bladder and Urachus -- Kidney -- Testis and Paratesticular Tissues -- Pancreas and Ampulla -- Liver, Bile Ducts and Gallbladder -- Upper Gastrointestinal Tract -- Lower Gastrointestinal Tract -- Soft Tissue and Bone Tumors -- Lymph Node -- Bone Marrow -- Infectious Diseases -- Skin -- Application of Direct Immunofluorescence for Skin and Mucosal Biopsies: A Practical Review -- Application of Fluorescent in Situ Hybridization (FISH) in Surgical and Cytologic Specimens (Solid Tumors, Hematopoietic Tumors, Urine, Bile Duct Brushing and Bronchoscopy).
Format
e-Book
Location
Online
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Traditional and folk herbal medicine. Volume 1. : recent researches

http://libcat.nshealth.ca/permalink/provcat32713
V. K. Gupta. Daya Pub. , c2013.
Available Online
View e-Book
Location
Online
In almost all the countries, traditional and folk herbal medicines have been extensively used since times immemorial for healthcare. Ancient religious texts are replete with references on the use of herbs with medicinal properties. Because of the local beliefs and practices and also from cost considerations herbal medicines remain a popular mode of treatment in the developing countries. In the industrialized society also, the rising cost of prescription drugs and ensuing side effects of the tr…
Available Online
View e-Book
Other Authors
Gupta, V K
Responsibility
V. K. Gupta
Place of Publication
New Delhi, India
Publisher
Daya Pub.
Date Published
c2013
Physical Description
627 p.
Series Vol.
Vol. 1
ISBN
9788170357667 (v. 1)
Subjects (MeSH)
Ethnopharmacology
Phytotherapy
Plants, Medicinal
Abstract
In almost all the countries, traditional and folk herbal medicines have been extensively used since times immemorial for healthcare. Ancient religious texts are replete with references on the use of herbs with medicinal properties. Because of the local beliefs and practices and also from cost considerations herbal medicines remain a popular mode of treatment in the developing countries. In the industrialized society also, the rising cost of prescription drugs and ensuing side effects of the treatment makes it highly attractive to use the traditional medicine. Considerable scientific data have been generated globally in this direction and there is a spurt of publications in recent years. In order to carry forward such investigations, there is a need for an effective exchange of information amongst scientists and researchers to take on vigorous focused work in this direction. Based on this rationale, the present volume Traditional and Folk Herbal Medicine: Recent Researches has been conceived and presents some 19 research and review papers by eminent scientists of India and abroad.
Format
e-Book
Location
Online
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