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Cause of death and the death certificate : important information for physicians, coroners, medical examiners, and the public

http://libcat.nshealth.ca/permalink/provcat38841
editor Randy Hanzlick. College of American Psychologists , c2006.
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Intended for any person who must prepare, review, or interpret cause-of-death statements appearing on death certificates or other medical documents, such as autopsy reports.
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Other Authors
Hanzlick, Randy
Responsibility
editor Randy Hanzlick
Alternate Title
Cause of death & the death certificate
Place of Publication
Northfield, IL
Publisher
College of American Psychologists
Date Published
c2006
Physical Description
1 online resource, 230 p.
ISBN
9781941096147
Subjects (MeSH)
Cause of death
Death certificates
Abstract
Intended for any person who must prepare, review, or interpret cause-of-death statements appearing on death certificates or other medical documents, such as autopsy reports.
Format
e-Book
Location
Online
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Intraepithelial neoplasia

http://libcat.nshealth.ca/permalink/provcat40972
Maode Lai, editor. Higher Education Press , c2009.
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Intraepithelial neoplasia (IEN) are some kind of preinvasive lesions. The definition and identification of intraepithelial neoplasia is exceedingly important for early diagnosis and prevention of malignancy. This book introduces for the first time the concept of intraepithelial neoplasia for the entire body in detail and the diagnostic applications of intraepithelial neoplasia in many organs and systems – including the respiratory and digestive systems, pancreas, bile duct, breast, prostate, ur…
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Other Authors
Lai, Maode
Responsibility
Maode Lai, editor
Place of Publication
Beijing, China
Publisher
Higher Education Press
Date Published
c2009
Physical Description
1 online resource (xiii, 364 p. : ill.)
ISBN
9783540854524 (print ed.)
9783540854531
Subjects (MeSH)
Carcinoma in situ - diagnosis
Carcinoma in situ - therapy
Precancerous conditions - diagnosis
Precancerous conditions - therapy
Abstract
Intraepithelial neoplasia (IEN) are some kind of preinvasive lesions. The definition and identification of intraepithelial neoplasia is exceedingly important for early diagnosis and prevention of malignancy. This book introduces for the first time the concept of intraepithelial neoplasia for the entire body in detail and the diagnostic applications of intraepithelial neoplasia in many organs and systems – including the respiratory and digestive systems, pancreas, bile duct, breast, prostate, urinary system, female genital system and the skin. The book features a large number of original figures – 450 – from Chinese patients with detailed descriptions. The book can serve as a diagnostic reference and as a research guide to preinvasive lesions for pathologists, oncologists and scientists. In addition, it will be able to help medical and pathology students improve their understanding of early neoplasia. Prof. Dr. med. Maode Lai is one of the most widely respected pathologists in China. He is vice president of Zhejiang University and Chairman-elect of the Chinese Society of Pathology. His major work is focused on molecular pathology of tumors, especially colorectal cancer.
Contents
Intraepithelial Neoplasia of the Respiratory Tract -- Intraepithelial Neoplasia of the Digestive Tract -- Intraepithelial Neoplasia of Pancreas, Biliary Tract and Gallbladder -- Intraepithelial Neoplasia of the Breast -- Prostatic Intraepithelial Neoplasia -- Urinary Intraepithelial Neoplasia (Intra-urothelial Neoplasia) -- Intraepithelial Neoplasia of the Female Reproductive Tract -- Intraepidermal Neoplasia of Skin --
Format
e-Book
Location
Online
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The Surgeon in Medieval English Literature

http://libcat.nshealth.ca/permalink/provcat40518
by Jeremy J. Citrome. Palgrave Macmillan , c2006.
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Jeremy Citrome employs the language of contemporary psychoanalysis to explain how surgical metaphors became an important tool of ecclesiastical power in the wake of the Fourth Lateran Council of 1215. Pastoral, theological, recreational, and medical writings are among the texts discussed in this wide-ranging study.
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Author
Citrome, Jeremy J
Responsibility
by Jeremy J. Citrome
Place of Publication
New York
Publisher
Palgrave Macmillan
Date Published
c2006
Physical Description
1 online resource (xi, 191 p.)
Series Title
New Middle Ages
ISBN
9781137096814
9781349734597 (print ed.)
Subjects (MeSH)
Christianity
General surgery - history
History, Medieval
Medicine in Literature
Other Subjects
United Kingdom
Abstract
Jeremy Citrome employs the language of contemporary psychoanalysis to explain how surgical metaphors became an important tool of ecclesiastical power in the wake of the Fourth Lateran Council of 1215. Pastoral, theological, recreational, and medical writings are among the texts discussed in this wide-ranging study.
Contents
Part I. Surgery and Metaphor -- 1. Surgery as Damnation in Cleanness -- 2. Salvation and The Siege of Jerusalem -- Part II. Surgery and Embodiment -- 3. The Priest: John Audelay's Wounds of Sin -- 4. The Surgeon: Surgery, Chivalry, and Sin in the Practica of ]ohn Arderne.
Format
e-Book
Location
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Normal findings in CT and MRI

http://libcat.nshealth.ca/permalink/provcat26756
Torsten B. Moeller, Emil Reif. Thieme , 2000.
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The key for any beginning radiologist who wishes to recognize pathological findings is to first acquire an ability to distinguish them from normal ones. This outstanding guide gives beginning radiologists the tools they need to systematically approach and recognize normal MR and CT images. Highlights include: Reference-quality images from the author's own teaching files show all standard normal findings as seen in CT and MRI; Checklists in each section offer the reader a systematic way to appro…
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Author
Möller, Torsten B
Other Authors
Reif, Emil
Responsibility
Torsten B. Moeller, Emil Reif
Place of Publication
Stuttgart
Publisher
Thieme
Date Published
2000
Physical Description
1 online resource (vi, 250 p.)
Series Title
Thieme flexibook
ISBN
9780865778641
9781604061291 (eISBN)
9783131165213
Subjects (MeSH)
Anatomy, Cross-Sectional
Magnetic Resonance Imaging
Reference Values
Tomography, X-Ray Computed
Abstract
The key for any beginning radiologist who wishes to recognize pathological findings is to first acquire an ability to distinguish them from normal ones. This outstanding guide gives beginning radiologists the tools they need to systematically approach and recognize normal MR and CT images. Highlights include: Reference-quality images from the author's own teaching files show all standard normal findings as seen in CT and MRI; Checklists in each section offer the reader a systematic way to approach the images; Thorough guidelines to help beginning radiologists dictate their reports; Lists of standard measurements and tips for ruling out pathology.
Format
e-Book
Location
Online
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Learned optimism : how to change your mind and your life

http://libcat.nshealth.ca/permalink/provcat26202
Martin E. P. Seligman. Vintage Books , c2006.
Call Number
BJ 1477 S465L 2006
Location
Dickson Building
Halifax Infirmary
Nova Scotia Hospital
Known as the father of the new science of positive psychology, Martin E.P. Seligman draws on more than twenty years of clinical research to demonstrate how optimism enchances the quality of life, and how anyone can learn to practice it. Offering many simple techniques, Dr. Seligman explains how to break an I--give-up habit, develop a more constructive explanatory style for interpreting your behavior, and experience the benefits of a more positive interior dialogue. These skills can help break …
Call Number
BJ 1477 S465L 2006
Author
Seligman, Martin E P
Responsibility
Martin E. P. Seligman
Place of Publication
New York, NY
Publisher
Vintage Books
Date Published
c2006
Physical Description
319 p.
ISBN
9781400078394
Subjects (MeSH)
Adaptation, Psychological
Attitude
Optimism
Stress, Psychological - prevention & control
Abstract
Known as the father of the new science of positive psychology, Martin E.P. Seligman draws on more than twenty years of clinical research to demonstrate how optimism enchances the quality of life, and how anyone can learn to practice it. Offering many simple techniques, Dr. Seligman explains how to break an I--give-up habit, develop a more constructive explanatory style for interpreting your behavior, and experience the benefits of a more positive interior dialogue. These skills can help break up depression, boost your immune system, better develop your potential, and make you happier.. With generous additional advice on how to encourage optimistic behavior at school, at work and in children, Learned Optimism is both profound and practical-and valuable for every phase of life. --Publisher.
Contents
Two ways of looking at life -- Learning to be helpless -- Explaining misfortune -- Ultimate pessimism -- How you think, how you feel -- Success at work -- Children and parents: the origins of optimism -- School -- Sports -- Health -- Politics, religion, and culture: a new psychohistory -- Optimistic life -- Helping your child escape pessimism -- Optimistic organization -- Flexible optimism.
Format
Book
Location
Dickson Building
Halifax Infirmary
Nova Scotia Hospital
Copies
3
Loan Period
3 weeks
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The athlete's shoulder

http://libcat.nshealth.ca/permalink/provcat31466
[edited by] Kevin E. Wilk, Michael M. Reinold, James R. Andrews. (2nd ed.) Churchill Livingstone/Elsevier , c2009.
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The latest edition of this in-depth look at athletic injuries of the shoulder has been updated to feature 16 new chapters, additional illustrations and algorithms, an added focus on arthroscopic treatments, and pearls that highlight key information. Additional contributing authors give you a fresh spin on new and old topics from rehabilitation exercises to special coverage of female athletes, pediatrics, and golfers. This book offers coverage of arthroscopy, total joint replacement, instability…
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Other Authors
Andrews, James R
Reinold, Michael M
Wilk, Kevin E
Responsibility
[edited by] Kevin E. Wilk, Michael M. Reinold, James R. Andrews
Edition
2nd ed.
Place of Publication
Philadelphia, PA
Publisher
Churchill Livingstone/Elsevier
Date Published
c2009
Physical Description
1 online resource (xix, 876 p.)
ISBN
9780702036057
Subjects (MeSH)
Athletic Injuries - therapy
Rotator cuff - injuries
Shoulder - injuries
Shoulder joint - injuries
Subjects (LCSH)
Athletic Injuries - therapy
Rotator Cuff - injuries
Shoulder - injuries
Shoulder - Wounds and injuries
Shoulder Joint - injuries
Sports injuries
Abstract
The latest edition of this in-depth look at athletic injuries of the shoulder has been updated to feature 16 new chapters, additional illustrations and algorithms, an added focus on arthroscopic treatments, and pearls that highlight key information. Additional contributing authors give you a fresh spin on new and old topics from rehabilitation exercises to special coverage of female athletes, pediatrics, and golfers. This book offers coverage of arthroscopy, total joint replacement, instability, football, tennis, swimming, and gymnastic injuries, rotator cuff injuries, and much, much more! The large range of topics covered in this text ensures that it's a great resource for orthopaedists, physical therapists, athletic trainers, and primary care physicians. Presents a multidisciplinary approach to the care of the shoulder, combining contributions from the leaders in the field of orthopedic surgery, physical therapy, and athletic training. Demonstrates which exercises your patients should perform in order to decrease their chance of injury or increase strength following an injury through illustrated exercises for rehabilitation and injury prevention. Illustrates how the shoulder is affected during activity of certain sports with a variety of tables and graphs. Covers a large range of topics including all shoulder injuries to be sufficiently comprehensive for both orthopaedists and physical therapists/athletic trainers.
Contents
Section I: Basic science -- Functional anatomy of the shoulder complex / Malcolm Peat, Elsie Culham, and Kevin E. Wilk -- Clinical biomechanics of the shoulder complex / Brian J. Eckenrode and Martin J. Kelley -- Section II: Examination -- Standardized shoulder examination----clinical and functional approaches / Terry R. Malone -- Clinical examination of the shoulder complex / Michael J. Kissenberth, James F. Silliman, and Richard J. Hawkins -- Diagnostic imaging of the shoulder complex / Martin L. Schwartz and D. Dean Thornton -- Section III: Arthroscopy -- Normal arthroscopic anatomy of the shoulder / William G. Carson, Jr. and Scott B. Reynolds -- Operative arthroscopy of the shoulder / Scott B. Reynolds ... [et al.] -- Arthroscopic techniques of the shoulder / William B. Geissler, Richard B. Caspari, and Scott B. Reynolds -- Section IV: Pathology and surgery -- Tensile failure of the rotator cuff / Christopher W. Baker and Brian D. Busconi -- Subacromial impingement / Sara L. Edwards, John-Erik Bell, and Louis U. Bigliani -- Internal impingement / Michael M. Reinold ... [et al.] -- Partial articular supraspinatus tendon avulsion (PASTA) lesions of the rotator cuff / Stephen J. Snyder and James L. Bond -- Calcific tendonitis / David G. Lemak and Lawrence J. Lemak -- Open repair of the rotator cuff / Matthew Rappé ... [et al.] -- Mini-open rotator cuff repair / Robert Afra, Ilya Voloshin, and Anthony Schepsis -- Arthroscopic rotator cuff repair / Ammar Anbari ... [et al.] -- Anterior instability of the shoulder / Samuel A. Taylor, Mark C. Drakos, and Stephen J. O'Brien -- Posterior sholder instability / John C. Austin ... [et al.] -- Multidirectional instability of the shoulder / John Uribe ... [et al.] -- Management of the first-time shoulder dislocation in the athlete / Robert Y. Wang ... [et al.] -- Bankart lesions: diagnosis and treatment with arthroscopic and open approaches / J.R. Rudski and David W. Altchek -- Superior labral anterior-posterior lesions of the shoulder / David A. Cortese and Stephen J. Snyder -- Soft tissue injuries of the shoulder / Judson W. Ott, William G. Clancy, Jr., and Kevin E. Wilk -- Adhesive capsulitis of the shoulder / E. Lyle Cain, Stephen M. Kocaj, and Kevin E. Wilk -- Acromioclavicular joint injuries / Albert Tom, Augustus D. Mazzocca, and Christ J. Pavlatos -- Shoulder arthroplasty in the athletic shoulder / Todd S. Ellenbecker and David S. Bailie -- Neurovascular compression syndromes of the shoulder / Champ L. Baker, Jr. and Champ L. Baker III -- Brachial plexus injuries / Tandy R. Freeman and William G. Clancy, Jr. -- Suprascapular nerve entrapment / Gregory Gebauer and Anthony J. Cosgarea -- Cervicogenic shoulder pain / Michael B. Fox, Benjamin Gelfand, and Stanley Rutkowski -- Section V: Sport specific injuries -- Biomechanics of the shoulder during sports / Glenn S. Fleisig, Shouchen Dun, and David Kingsley -- Electromyographic activity during upper extremity sports / Rafael Excamilla -- Shoulder injuries in baseball / Kevin E. Wilk ... [et al.] -- Shoulder injuries in football / Brian D. Busconi, Christopher W. Baker, and Thomas J. Gill -- Shoulder injuries in tennis / Todd S. Ellenbecker, E. Paul Roetert, and Marc Safran -- The shoulder in swimming / George J. Davies ... [et al.] -- Conditioning, training, and rehabilitation for the golfer's shoulder / Russell M. Paine and Ron M. Johnson -- The artistic gymnast's shoulder / Larry Nassar and William Sands -- Pediatric shoulder injuries / Peter D. Asnis, Erik M. Berkson, and Thomas J. Gill -- Female shoulder injuries / Jo A. Hannafin, Monique A. Sheridan, and Theresa A. Chiaia -- Section VI: Rehabilitation principles -- Nonoperative treatment of shoulder impingement / Michael A. Keirns and Julie M. Whitman -- Nonoperative rehabilitation for traumatic and congenital glenohumeral instability / Kevin E. Wilk, Leonard C. Macrina, and Michael M. Reinold -- Strength and conditioning for the preadolescent and adolescent athlete / Leonard C. Macrina and Michael M. Reinold -- Injuries and rehabilitation of the overhead female athlete's shoulder / Airelle O. Hunter-Giordano ... [et al.] -- Biomechanical considerations in shoulder rehabilitation exercises / Michael M. Reinold and Edgar T. Savidge -- Open- and closed-chain rehabilitation for the shoulder complex / Rafael Escamilla and Kyle Yamashiro -- Neuromuscular control exercises for shoulder instability / Steven Hoffman ... [et al.] -- Proprioceptive neuromuscular facilitation for the shoulder / Bruce Greenfield -- Sensorimotor contribution to shoulder joint stability / Joseph B. Myers, Craig A. Wassinger, and Scott M. Lephart -- The role of the scapula in rehabilitation / Tim L. Uhl and W. Ben Kibler -- Alternative techniques for the motion-restricted shoulder / Robert E. Mangine, Matthew J. Ernst, and Marsha Eifert-Mangine -- The decelerator mechanism: eccentric muscular contraction applications at the shoulder / J. Gregory Bennett -- Neurodynamic techniques for the athlete's shoulder / John Tomberlin -- Isokinetic testing and rehabilitation of the shoulder complex / George J. Davies, Todd S. Ellenbecker, and Kevin E. Wilk -- Plyometrics for the shoulder complex / Kevin E. Wild and Michael L. Voight -- Core stabilization: integration with shoulder rehabilitation / Sue Falsone and Mark Verstegen -- Conditioning of the shoulder complex for specific sports / Ken Crenshaw ... [et al.] -- Interval sport programs for the shoulder / Kevin E. Wilk, Michael M. Reinold, and Adam C. Olsen -- Taping, padding, and bracing for the shoulder complex / Jeff G. Konin, Thomas J. Kuster III, and Mark D. Miller -- Shoulder outcome measures / Tara Ridge and James J. Irrgang.
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Clinical tests for the musculoskeletal system : examinations, signs, phenomena

http://libcat.nshealth.ca/permalink/provcat27422
Klaus Buckup. (2nd ed.) Thieme , c2008.
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The mainstay of orthopedic diagnosis continues to be the physical examination of the patient following a thorough history. This convenient pocketbook presents a comprehensive collection of the clinical tests that are used in orthopedic diagnosis, thereby answering the following questions: What tests are available for examining a particular joint, and how are they to be interpreted? What is meant by the name of a test that is mentioned in the literature or in a physician's report? The methodolog…
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Author
Buckup, Klaus
Responsibility
Klaus Buckup
Edition
2nd ed.
Place of Publication
Stuttgart
Publisher
Thieme
Date Published
c2008
Physical Description
1 online resource (326 p.)
ISBN
9783131367921
9783131494917 (eISBN)
Subjects (MeSH)
Diagnostic Tests, Routine
Musculoskeletal Diseases - diagnosis
Abstract
The mainstay of orthopedic diagnosis continues to be the physical examination of the patient following a thorough history. This convenient pocketbook presents a comprehensive collection of the clinical tests that are used in orthopedic diagnosis, thereby answering the following questions: What tests are available for examining a particular joint, and how are they to be interpreted? What is meant by the name of a test that is mentioned in the literature or in a physician's report? The methodology and interpretation of all relevant test procedures are presented in almost 500 instructive drawings and brief descriptions: Initial tests, Functional tests, Stress tests, Stability tests. Tables on the examination of the spinal column, shoulder joint, and knee joint help in selecting the most suitable examinations. An invaluable aid for physical therapists, orthopedic surgeons, and primary care or emergency room physicians.
Format
e-Book
Location
Online
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Work it out : using personality type to improve team performance

http://libcat.nshealth.ca/permalink/provcat32888
Sandra Krebs Hirsh & Jane A. G. Kise. (Rev. ed.) Davies-Black Pub. , c2006.
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Managers come and go. Projects end and teams disband. No matter how often or how quickly business events change, people and the resulting conflicts remain very much the same. For nearly a decade, Work It Out has been at the forefront helping business leaders, managers and consultants simplify the complex-and sometimes chaotic-interactions between people at work. Now with fresh insights on applying key concepts from the Myers-Briggs Type Indicator (MBTI) tool in executive coaching, plus more ha…
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Author
Hirsh, Sandra Krebs
Other Authors
Kise, Jane A G
Responsibility
Sandra Krebs Hirsh & Jane A. G. Kise
Edition
Rev. ed.
Place of Publication
Mountain View, CA
Publisher
Davies-Black Pub.
Date Published
c2006
Physical Description
1 online resource (xiii, 248 p.)
ISBN
9780891063667
Subjects (MeSH)
Communication in management
Conflict management
Employees - psychology
Interpersonal Communication
Myers-Briggs Type Indicator
Abstract
Managers come and go. Projects end and teams disband. No matter how often or how quickly business events change, people and the resulting conflicts remain very much the same. For nearly a decade, Work It Out has been at the forefront helping business leaders, managers and consultants simplify the complex-and sometimes chaotic-interactions between people at work. Now with fresh insights on applying key concepts from the Myers-Briggs Type Indicator (MBTI) tool in executive coaching, plus more hands-on exercises and examples, this newly revised edition of Work It Out expands its focus.
Contents
Working it out with type : can it make a difference for you? -- The extraversion-introversion dichotomy : the case of the communication conundrum -- The sensing-intuition dichotomy : to improve or expand? -- The thinking-feeling dichotomy : executive styles -- The judging-perceiving dichotomy : deadline dilemmas -- Function pairs : ST, SF, NF, NT in the workplace -- Style-changing stress : the inferior function-the shadow -- Influencing upward : the problem is the boss-or is it? -- Coaching yourself, coaching others : putting type to work for you -- A leader who put type to work : management style with type.
Format
e-Book
Location
Online
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Establishing Medical Reality : Essays In The Metaphysics And Epistemology Of Biomedical Science

http://libcat.nshealth.ca/permalink/provcat40572
edited by Harold Kincaid and Jennifer McKitrick. Springer , c2007.
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Medicine raises numerous philosophical issues. Most discussed have been debates in bioethics. Yet contemporary medicine is also a rich source of controversies and examples that raise important issues in philosophy of science, philosophy of biology, and metaphysics. This volume approaches the philosophy of medicine from the broad naturalist perspective that holds that philosophy must be continuous with, constrained by, and relevant to empirical results of the natural and social sciences and that…
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Other Authors
Kincaid, Harold, 1952-
McKitrick, Jennifer
Responsibility
edited by Harold Kincaid and Jennifer McKitrick
Place of Publication
Dordrecht
Publisher
Springer
Date Published
c2007
Physical Description
1 online resource (vii, 236 p.)
Series Vol.
v. 90
Series Title
Philosophy and medicine
ISBN
9781402052156 (print ed.)
9781402052163
Subjects (MeSH)
Bioethical issues
Metaphysics
Philosophy, Medical
Abstract
Medicine raises numerous philosophical issues. Most discussed have been debates in bioethics. Yet contemporary medicine is also a rich source of controversies and examples that raise important issues in philosophy of science, philosophy of biology, and metaphysics. This volume approaches the philosophy of medicine from the broad naturalist perspective that holds that philosophy must be continuous with, constrained by, and relevant to empirical results of the natural and social sciences and that believes that the history, sociology, politics, and ethics of science provide relevant information for philosophical analysis. One traditional topic covered by several of the contributions is the nature of disease, but the approach is largely from the philosophy of science rather than traditional linguistic analysis. The complex interplay of epistemological and sociological factors in producing evidence in medicine is discussed by chapters on collective medical discussion making, experimental medicine, "genetic" diseases, mental illness, and race and gender categories. The upshot is a volume that ties medicine to contemporary issues in philosophy of science and metaphysics like no other. "An excellent collection of essays in the philosophy of medicine. Whereas most philosophical work about medicine has been concerned with medical ethics, this volume focuses more on key questions in epistemology and metaphysics, although many of these are also relevant to ethical issues. Some of the chapters are among the best I have read in the philosophy of medicine on their respective topics." Professor Paul Thagard, Philosophy Department, University of Waterloo, Ontario, Canada.
Contents
Introduction -- Normality, Disease and Enhancement -- Holistic Theories of Health as Applicable to Non-Human Living Beings -- Disease and the Concept of Supervenience -- Decision and Discovery in Defining "Disease" -- Race and Scientific Reduction -- Towards an Adequate Account of Genetic Disease -- Why Disease Persists: An Evolutionary Nosology -- Creating Mental Illness in Non-Disordered Community Populations -- Gender Identity Disorder -- Clinical Trials as Nomological Machines: Implications for Evidence-Based Medicine -- The Social Epistemology of NIH Consensus Conferences -- Maternal Agency and the Immunological Paradox of Pregnancy -- Violence and Public Health: Exploring the Relationship Between Biological Perspectives on Violent Behavior and Public Health Approaches to Violence Prevention -- Taking Equipoise Seriously: The Failure of Clinical or Community Equipoise to Resolve the Ethical Dilemmas in Randomized Clinical Trials.
Format
e-Book
Location
Online
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The Histone Code and Beyond : New Approaches to Cancer Therapy

http://libcat.nshealth.ca/permalink/provcat40551
S.L. Berger, O. Nakanishi, B. Haendler, editors. Springer Berlin Heidelberg , c2006.
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Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structur…
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Other Authors
Berger, S. L
Haendler, B
Nakanishi, O
Responsibility
S.L. Berger, O. Nakanishi, B. Haendler, editors
Place of Publication
Berlin, Heidelberg
Publisher
Springer Berlin Heidelberg
Date Published
c2006
Physical Description
1 online resource (xiv, 215 p.)
Series Vol.
57
Series Title
Ernst Schering Research Foundation workshop
ISBN
9783540278573 (print ed.)
9783540376330
ISSN
0947-6075
Subjects (MeSH)
Histones
Abstract
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Contents
The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development -- Nucleosome Structure and Function -- The Role of Snf2-Related Proteins in Cancer -- Imitation Switch Complexes -- How Is Epigenetic Information on Chromatin Inherited After DNA Replication? -- Polycomb Silencing Mechanisms and Genomic Programming -- CpG Island Methylation and Histone Modifications: Biology and Clinical Significance -- Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces Cerevisiae -- Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis -- Role of Ubiquitin-Like Proteins in Transcriptional Regulation -- Interplay of the SUMO and MAP Kinase Pathways.
Format
e-Book
Publication Type
Congresses
Location
Online
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