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Meeting the needs of older adults with serious illness : challenges and opportunities in the age of health care reform

http://libcat.nshealth.ca/permalink/provcat33913
Amy S. Kelley, Diane E. Meier, editors. Springer , c2014.
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Meeting the Needs of Older Adults with Serious Illness: Challenges and Opportunities in the Age of Health Care Reform provides an introduction to the principles of palliative care, describes current models of delivering palliative care across care settings, and examines opportunities in the setting of healthcare policy reform for palliative care to improve outcomes for patients, families and healthcare institutions. The United States is currently facing a crisis in health care marked by unsusta…
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Other Authors
Kelley, Amy S.
Meier, Diane E.
Responsibility
Amy S. Kelley, Diane E. Meier, editors
Place of Publication
New York
Publisher
Springer
Date Published
c2014
Physical Description
1 online resource (xiii, 240 pages)
Series Title
Aging medicine
ISBN
9781493904068
9781493904075 (electronic bk.)
Subjects (MeSH)
Aged
Health Care Reform
Health Services for the Aged
Insurance, Health
Palliative Care - economics
Quality of Health Care
United States
United States. Patient Protection and Affordable Care Act
Subjects (LCSH)
Older people - Hospice care
Older people - Medical care
Palliative treatment
Terminal care
Abstract
Meeting the Needs of Older Adults with Serious Illness: Challenges and Opportunities in the Age of Health Care Reform provides an introduction to the principles of palliative care, describes current models of delivering palliative care across care settings, and examines opportunities in the setting of healthcare policy reform for palliative care to improve outcomes for patients, families and healthcare institutions. The United States is currently facing a crisis in health care marked by unsustainable spending and quality that is poor relative to international benchmarks. Yet this is also a critical time of opportunity. Because of its focus on quality of care, the Affordable Care Act is poised to expand access to palliative care services for the sickest, most vulnerable, and therefore most costly, 5% of patients- a small group who nonetheless drive about 50% of all healthcare spending. Palliative care is specialized medical care for people with serious illnesses. It focuses on providing patients with relief from the symptoms, pain, and stress of a serious illness--whatever the diagnosis or stage of illness. The goal is to improve quality of life for both the patient and the family. Research has demonstrated palliative care's positive impact on health care value. Patients (and family caregivers) receiving palliative care experience improved quality of life, better symptom management, lower rates of depression and anxiety, and improved survival. Because patient and family needs are met, crises are prevented, thereby directly reducing need for emergency department and hospital use and their associated costs. An epiphenomenon of better quality of care, the lower costs associated with palliative care have been observed in multiple studies. Meeting the Needs of Older Adults with Serious Illness: Challenges and Opportunities in the Age of Health Care Reform, a roadmap for effective policy and program design, brings together expert clinicians, researchers and policy leaders, who tackle key areas where real-world policy options to improve access to quality palliative care could have a substantial role in improving value.
Contents
Part I. Current Needs of Older Adults with Serious Illness -- 1. When More Is Less: Overuse of Medical Services Harms Patients -- 2. Disparities in Access to Palliative Care -- 3. Family Caregiving and Palliative Care: Aligning Theory, Practice, and Policy -- Part II. Settings for the Care of the Seriously Ill -- 4. This Is Your Life: Achieving a Comprehensive, Person-Centered Model of Care at the Intersection of Policy, Politics, and Private Sector Innovation -- 5. Hospice and Healthcare Reform: What Is the Optimal Path? -- 6. Palliative Care in the Long-Term Care Setting -- Part III. Measuring Quality and Paying for the Care of the Seriously Ill -- 7. Quality and Outcome Measures -- 8. Palliative Care’s Impact on Utilization and Costs: Implications for Health Services Research and Policy -- 9. Long-term Services and Supports: A Necessary Complement to Palliative Care -- 10. The Manifest Destinies of Managed Care and Palliative Care -- Part IV. Platforms for Improvement -- 11. Models of Care Delivery and Coordination: Palliative Care Integration Within Accountable Care Organizations -- 12. Implementing a Care Planning System: How to Fix the Most Pervasive Errors in Health Care -- 13. Igniting Action to Integrate Palliative Care in Our US Health System: The Role of Disease-Specific Advocacy Groups—A Cancer Advocacy Case Study -- 14. What Do You Mean You Don’t Also Offer Palliative Care? Effective Public Engagement to Harness Demand to Improve Care for Serious Illness -- 15. Research Priorities in Palliative Care for Older Adults -- 16. Medical and Nursing Education & Training.
Format
e-Book
Location
Online
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Targeted Therapeutics in Melanoma

http://libcat.nshealth.ca/permalink/provcat31011
Thomas F. Gajewski, F. Stephen Hodi, editors. Humana Press , c2012.
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Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas–over-exposure to ultraviolet light–is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development o…
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Other Authors
Gajewski, Thomas F
Hodi, F. Stephen
Responsibility
Thomas F. Gajewski, F. Stephen Hodi, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date Published
c2012
Physical Description
1 online resource (xiv, 377 p. : 27 ill., 22 ill. in color)
Series Title
Current clinical oncology
ISBN
9781617794070
Subjects (MeSH)
Melanoma - drug therapy
Molecular Targeted Therapy - methods
Subjects (LCSH)
Dermatology
Molecular medicine
Oncology
Abstract
Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas–over-exposure to ultraviolet light–is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies. This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers.
Contents
Molecular targets and subtypes in melanoma -- Melanoma genomics -- Predictive biomarkers as a guide to future therapy selection in melanoma -- KIT as a therapeutic target for melanoma -- Targeted inhibition of B-Raf -- The notch and [beta]-catenin pathways -- STAT3 and Src signaling in melanoma -- Targeting the mTOR, PI3K and AKT pathways in melanoma -- Targeting apoptotic pathways in melanoma -- Anti-angiogenesis therapy in melanoma -- Melanoma antigens recognized by T lymphocytes -- Melanoma vaccines -- Adoptive cell therapy for the treatment of metastatic melanoma -- Anti-CTLA-4 monolonal antibodies -- Anti-PD-1 and Anti-B7-H1/PD-L1 monoclonal antibodies -- Treatment of melanoma with agonist immune co-stimulatory agents -- Novel cytokines for immunotherapy of melanoma -- Modulating the tumor microenvironment.
Format
e-Book
Location
Online
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Peter H.C. Lim, editor. Springer , c2013.
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Men's Health is a concise, didactic compendium that covers three important aspects of male sexual health: Testosterone Deficiency Syndrome; Premature Ejaculation and Sexually Transmitted Infections (STIs). The chapters that deal with Testosterone Deficiency Syndrome cover the epidemiology of the condition in the local context, the science behind the condition, its clinical presentation and treatment choices. The section on Premature Ejaculation advises the health practitioner on how to invest…
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Lim, Peter H.C
Responsibility
Peter H.C. Lim, editor
Place of Publication
London
Publisher
Springer
Date Published
c2013
Physical Description
1 online resource (xviii, 204 p. : 46 ill., 41 ill. in color)
ISBN
9781447147664
Subjects (MeSH)
Hypogonadism
Men's Health
Premature Ejaculation
Reproductive Health
Sexual Dysfunction, Physiological
Sexually Transmitted Diseases
Subjects (LCSH)
Endocrinology
Infectious diseases
Reproductive medicine
Urology
Abstract
Men's Health is a concise, didactic compendium that covers three important aspects of male sexual health: Testosterone Deficiency Syndrome; Premature Ejaculation and Sexually Transmitted Infections (STIs). The chapters that deal with Testosterone Deficiency Syndrome cover the epidemiology of the condition in the local context, the science behind the condition, its clinical presentation and treatment choices. The section on Premature Ejaculation advises the health practitioner on how to investigate this condition and describes the various treatment options available to the patient. The chapters on Sexually Transmitted Infections cover special aspects of the diagnosis, prevention and treatment of STIs occurring in Men which are not normally highlighted in the usual texts on STI management. Written by experts in the field, Men's Health is a valuable and timely resource for urologists, andrologists, endocrinologists as well as other health professionals practicing in these areas.
Contents
Part I: Hypogonadism -- 1. Epidemiology: Late-Onset Hypogonadism in Singapore -- 2. Pathophysiology of Late-Onset Hypogonadism and Risks and Benefits of Replacement Therapy -- 3. Testosterone Assays and Their Potential Pitfalls -- 4. Diagnosing and Evaluating Androgen Deficiency, Including Andropause -- 5. Testosterone Preparations for Treatment of Hypogonadal Men -- 6. Androgens, Use, Misuse, and Abuse -- 7. Testosterone Therapy, Prostate Safety, and Other Safety Issues -- 8. The Role of Testosterone in the Metabolic Syndrome in Men -- 9. The Testosterone and ED (or Sexual Function) Connection -- 10. Treating Hypogonadism Associated with Erectile Dysfunction -- 11. Traditional Asian Herbs: Potential Use for Late-Onset Hypogonadism? -- 12. Effects of Excessive Androgen Use and Abuse -- 13. Practice Pointers for the Practitioner -- 14. Collection Charts/Questionnaires/Testosterone Calculators/Other Aide-Memoires, etc. for the GP -- Part II:Premature Ejaculation -- 15. Introduction -- 16. Etiology of Premature Ejaculation -- 17. Initial Workup and Use of Assessment Tools -- 18. Initial Management of the Newly Diagnosed PE -- 19. Premature Ejaculation: Simple Behavioral Therapy Steps -- 20. Choice of Pharmacologic Agents -- 21. Premature Ejaculation: Treatment of the Difficult Case and Advanced Counseling Techniques and When to Refer -- 22. Management of the Infertile Couple When the Male Partner Has Ejaculatory Dysfunction -- 23. Delayed/Retarded Ejaculation -- 24. Collection of Bedside Aids for Diagnosis and Tools for Assessment of Treatment to Goal -- 25. Frequently Asked Questions on Dapoxetine (FAQ’S) -- Part III: Sexually Transmitted Infections -- 26. Overview -- 27. HIV/AIDS -- 28. Breaking the News and Counseling -- 29. Prostatitis in Men -- 30. STIs, Depression and Sexual Dysfunction -- 31. Guidelines: Making the Diagnosis and Managing the Partner -- Index .
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e-Book
Location
Online
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Methods of Clinical Epidemiology

http://libcat.nshealth.ca/permalink/provcat40799
Suhail A. R. Doi, Gail M. Williams, editors. Springer , c2013.
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Methods of Clinical Epidemiology serves as a text on methods useful to clinical researchers. It provides a clear introduction to the common research methodology specific to clinical research for both students and researchers. This book sets out to fill the gap left by texts that concentrate on public health epidemiology and focuses on what is not covered well in such texts. The four sections cover methods that have not previously been brought together in one text and serves as a second level te…
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Doi, Suhail A. R
Williams, Gail M
Responsibility
Suhail A. R. Doi, Gail M. Williams, editors
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date Published
c2013
Physical Description
1 online resource (xvi, 282 p. : ill.)
Series Title
Springer Series on Epidemiology and Public Health
ISBN
9783642371301 (print ed.)
9783642371318
ISSN
1869-7933
Subjects (MeSH)
Clinical Laboratory Techniques
Epidemiologic Methods
Abstract
Methods of Clinical Epidemiology serves as a text on methods useful to clinical researchers. It provides a clear introduction to the common research methodology specific to clinical research for both students and researchers. This book sets out to fill the gap left by texts that concentrate on public health epidemiology and focuses on what is not covered well in such texts. The four sections cover methods that have not previously been brought together in one text and serves as a second level textbook of clinical epidemiology methodology. This book will be of use to postgraduate students in clinical epidemiology as well as clinical researchers at the start of their careers.
Contents
Part I. Clinical Agreement -- 1. Clinical Agreement in Qualitative Measurements -- 2. Clinical Agreement in Quantitative Measurements -- 3. Disagreement Plots and the Intraclass Correlation in Agreement Studies -- 4. The Coefficient of Variation as an Index of Measurement Reliability -- Part II. Diagnostic Tests -- 5. Using and Interpreting Diagnostic Tests with Dichotomous or Polychotomous Results -- 6. Using and Interpreting Diagnostic Tests with Quantitative Results -- 7. Sample Size Considerations for Diagnostic Tests -- 8. An Introduction to Diagnostic Meta-analysis -- 9. Health Technology Assessments of Diagnostic Tests -- Part III. Modeling Binary and Time-to-Event Outcomes -- 10. Modelling Binary Outcomes -- 11. Modelling Time-to-Event Data -- Part IV. Systematic Reviews and Meta-analysis -- 12. Systematic Reviewing -- 13. Quality Assessment in Meta-analysis -- 14. Meta-analysis I -- 15. Meta-analysis II -- Appendix: Stata codes.
Format
e-Book
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Online
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Mindfulness for therapists : practice for the heart

http://libcat.nshealth.ca/permalink/provcat33527
Eric E. McCollum. Routledge/Taylor and Francis , 2015.
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Mindfulness for Therapists: Practice for the Heart encourages therapists to embrace mindfulness practice to create presence and depth in their work with clients. Mindfulness helps therapists cultivate compassion, relieve stress, and weather the often emotionally difficult work of providing therapy. In addition, the therapist''s own meditation practice is a necessary foundation for teaching mindfulness to clients. Through a variety of exercises and stories from his own clinical experience, McCo…
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Author
McCollum, Eric E
Responsibility
Eric E. McCollum
Place of Publication
New York, NY
Publisher
Routledge/Taylor and Francis
Date Published
2015
Physical Description
1 online resource (116 p.)
ISBN
9781317616641
Subjects (MeSH)
Burnout, Professional - prevention & control
Mindfulness
Psychotherapy - methods
Self-care - psychology
Subjects (LCSH)
Burnout, Professional -- prevention & control
Mindfulness
Psychotherapy
Psychotherapy -- methods
Self Care -- psychology
Notes
Description based upon print version of record
Abstract
Mindfulness for Therapists: Practice for the Heart encourages therapists to embrace mindfulness practice to create presence and depth in their work with clients. Mindfulness helps therapists cultivate compassion, relieve stress, and weather the often emotionally difficult work of providing therapy. In addition, the therapist''s own meditation practice is a necessary foundation for teaching mindfulness to clients. Through a variety of exercises and stories from his own clinical experience, McCollum helps therapists understand the usefulness of mindfulness, and develop their own practice.
Contents
Cover; Title; Copyright; Contents; Preface; 1 The Challenge of Presence in a Multitasking World; Being and Doing as Therapists; 2 What Is Mindfulness?; A Taste of Mindfulness; The Path to Being; Misconceptions; Mindlessness; So What Is Mindfulness?; 3 What Do We Know About Mindfulness? The Research Record; General Effects of Mindfulness; Mindfulness for Physical and Psychological Problems; Outcome Research in Health Care/Psychological Arenas; 4 How Does Mindfulness Benefit Therapists?; Therapists' Stress; What Can Mindfulness Contribute?; 5 Cultivating Mindfulness -- Setting the Stage for PracticeBreath Meditation; The Next Step; What Is Happening in This Moment?; 6 The Complexities of Compassion; What's So Hard About Compassion?; Fears of Compassion; Lovingkindness Meditation; Practicing Lovingkindness Meditation; 7 Things Get in the Way: Obstacles to Being Present; Desire; Aversion; Sluggishness and Restlessness; Doubt; 8 Practicing to Be Present; The Psychological Container; Preparing for Practice; The Active Mind; 9 A Final Thought; References; Index; Resources.
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e-Book
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Online
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Atlas of Single-Port, Laparoscopic, and Robotic Surgery : A Practical Approach in Gynecology

http://libcat.nshealth.ca/permalink/provcat39581
Pedro F. Escobar, Tommaso Falcone, editors. Springer , c2014.
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Minimally invasive surgery has become the standard treatment for many diseases and conditions. In the last decade, numerous studies have demonstrated that laparoscopic approaches have improved patients' quality of life if compared with standard open procedures. Atlas of Single-Port, Laparoscopic, and Robotic Surgery serves as a guide in single-port, standard laparoscopy, and robotic surgery and shows how novel techniques, such as single-port laparoscopy and robotics, have recently evolved. The …
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Other Authors
Escobar, Pedro F
Falcone, Tommaso
Responsibility
Pedro F. Escobar, Tommaso Falcone, editors
Place of Publication
New York, NY
Publisher
Springer
Date Published
c2014
Physical Description
1 online resource (xiii, 330 p. : 297 illus., 291 illus. in color)
ISBN
9781461468394 (print ed.)
9781461468400
Subjects (MeSH)
Gynecologic Surgical Procedures - methods
Laparoscopy - instrumentation
Laparoscopy - methods
Robotic Surgical Procedures - methods
Robotics - instrumentation
Abstract
Minimally invasive surgery has become the standard treatment for many diseases and conditions. In the last decade, numerous studies have demonstrated that laparoscopic approaches have improved patients' quality of life if compared with standard open procedures. Atlas of Single-Port, Laparoscopic, and Robotic Surgery serves as a guide in single-port, standard laparoscopy, and robotic surgery and shows how novel techniques, such as single-port laparoscopy and robotics, have recently evolved. The atlas illustrates the unique challenges that the new single-port surgery modality presents, including instruments crowding and articulation, and the advanced laparoscopic skills required to perform these procedures, such as the ability to move and control a flexible camera. It also illustrates how to efficiently and safely utilize the robot to perform most gynecologic procedures. This exceptional resource provides students, residents, fellows, operating room personnel, and practicing gynecologic surgeons with invaluable information about instrumentation, surgical technique, port systems, and the current research and development in robotics.
Contents
Basic Principles and Anatomy for the Laparoscopic Surgeon -- Laparoscopic Myomectomy -- Laparoscopic Adnexal Surgery -- Laparoscopic Total and Supracervical Hysterectomy -- Laparoscopic Excision of Endometriosis -- Techniques in Gynecologic Oncology -- Techniques in Urogynecology and Pelvic Reconstructive Surgery -- Techniques in Reproductive Surgery -- Instrumentation for Single-Site Gynecologic Surgery -- Single-Port Laparoscopic Adnexal Surgery -- Single-Port Laparoscopic Hysterectomy -- Single-Port Laparoscopic Management of Endometriosis -- Techniques for Single-Port Gynecologic Oncology -- Techniques for Single-Port Urogynecology and Pelvic Reconstructive Surgery -- Instrumentation, Platforms, and Basic Principles Robotics -- Robotic- Assisted Laparoscopic Myomectomy -- Robotic-Assisted Total Laparoscopic Hysterectomy -- Robotic-Assisted Management of Endometriosis -- Robotic Surgery in Gynecologic Oncology -- Techniques for Robotic Urogynecology and Pelvic Reconstructive Surgery -- Techniques for Robotic Tubal Surgery -- Management of Laparoscopy-Related Complications -- Single-Port Robotics.
Format
e-Book
Location
Online
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Minimally invasive therapy for urinary incontinence and pelvic organ prolapse

http://libcat.nshealth.ca/permalink/provcat33835
Gopal H. Badlani, editor. Humana Press , c2014.
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Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse provides a detailed insight into "when, why, what and how" of various minimally invasive surgical procedures for surgical management of SUI, OAB and POP. The volume provides detailed diagrammatic and pictorial step-by-step descriptions of the techniques and management of complications related to these procedures. This book also presents an up to date, one-stop reference for anything pertaining to MIT of these pelvic d…
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Other Authors
Badlani, Gopal H.
Responsibility
Gopal H. Badlani, editor
Place of Publication
New York
Publisher
Humana Press
Date Published
c2014
Physical Description
1 online resource (xiii, 286 pages)
Series Title
Current clinical urology
ISBN
9781493900077
9781493900084 (electronic bk.)
Subjects (MeSH)
Minimally Invasive Surgical Procedures
Pelvic Floor Disorders - surgery
Prolapse
Urinary Incontinence - surgery
Subjects (LCSH)
Pelvic floor
Urinary incontinence
Uterus - Prolapse
Abstract
Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse provides a detailed insight into "when, why, what and how" of various minimally invasive surgical procedures for surgical management of SUI, OAB and POP. The volume provides detailed diagrammatic and pictorial step-by-step descriptions of the techniques and management of complications related to these procedures. This book also presents an up to date, one-stop reference for anything pertaining to MIT of these pelvic disorders.
Contents
Part I. Introduction/Basics -- Basic Urologic History and Questionnaires and the Role of Imaging in Female Pelvic Medicine and Reconstructive Surgery -- Urodynamics: Indications, Technique, and Fluoroscopy -- Part II. Female Stress Urinary Incontinence -- Retropubic Midurethral Synthetic Slings for Female Stress Urinary Incontinence -- Transobturator Tape -- Female SUI: Single-Incision Slings -- Fascial Slings: Is There Still a Place? -- Female Stress Urinary Incontinence Surgery Complications: Diagnosis, Evaluation, and Management -- Part III. Male Incontinence -- The Artificial Urinary Sphincter -- Complications of Male Incontinence Procedures: Diagnosis, Evaluation, and Management -- Stem Cells for the Treatment of Stress Urinary Incontinence -- Treatment of Overactive Bladder Refractory to Medications -- Part IV. Overactive Bladder -- Intravesical Therapy for Refractory Overactive Bladder and Detrusor Overactivity in Adults: Botulinum Toxin-A -- Part V. Neuromodulation -- Sacral Neurostimulation: InterStim -- Neuromodulation: PTNS -- Pudendal Nerve Stimulation -- Part VI. Pelvic Organ Prolapse -- Pelvic Organ Prolapse: Planning for Surgery--Indications, Decision, Special Instruments, and Controversies -- Materials for Pelvic Repair -- Pelvic Organ Prolapse: Anterior Compartment-Kits and Customised Repairs -- Pelvic Organ Prolapse: Posterior Repairs -- Apical Repairs -- POP Complications and Their Management -- Minimally Invasive Abdominal Surgery in the Management of Pelvic Dysfunction.
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e-Book
Location
Online
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Mitochondrial function in lung health and disease

http://libcat.nshealth.ca/permalink/provcat33880
Viswanathan Natarajan, Narasimham L. Parinandi, editors. Humana Press , c2014.
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Mitochondria, often referred to as the 'powerhouses' of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysf…
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Natarajan, Viswanathan
Parinandi, Narasimham L.
Responsibility
Viswanathan Natarajan, Narasimham L. Parinandi, editors
Place of Publication
New York
Publisher
Humana Press
Date Published
c2014
Physical Description
1 online resource (xi, 222 pages)
Series Vol.
v. 15
Series Title
Respiratory medicine (New York, N.Y.)
ISBN
9781493908288
9781493908295 (electronic bk.)
Subjects (MeSH)
Lung Diseases - metabolism
Mitochondrial Diseases
Subjects (LCSH)
Lung Diseases - physiopathology
Lungs - Diseases - Molecular aspects
Mitochondrial pathology
Abstract
Mitochondria, often referred to as the 'powerhouses' of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.
Contents
Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases -- Regulation of Mitochondrial Functions by Transcription Factor NRF2 -- Mitochondrion: A Missing Link in Asthma Pathogenesis -- ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea -- Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle -- Mitochondrial Lipid Peroxidation in Lung Damage and Disease -- The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung -- Mitochondrial Function in Lung Health and Disease -- Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial Damage.
Format
e-Book
Location
Online
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The molecular basis of cancer

http://libcat.nshealth.ca/permalink/provcat32894
[edited by] John Mendelsohn, Joe W. Gray, Peter M. Howley ... [et al.]. (4th ed.) Saunders Elsevier , c2015.
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The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials …
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Mendelsohn, John
Responsibility
[edited by] John Mendelsohn, Joe W. Gray, Peter M. Howley ... [et al.]
Edition
4th ed.
Place of Publication
Philadelphia, PA
Publisher
Saunders Elsevier
Date Published
c2015
Physical Description
1 online resource (863 p.)
ISBN
9781455740666
Subjects (MeSH)
Molecular Biology - methods
Molecular Targeted Therapy
Neoplasms - genetics
Neoplasms - pathology
Abstract
The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy.
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e-Book
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Molecular Diagnostics : 12 Tests That Changed Everything

http://libcat.nshealth.ca/permalink/provcat39597
W. Edward Highsmith, Jr., editor. Springer New York : Imprint: Humana Press , c2014.
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Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test ha…
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Highsmith, Jr., W. Edward
Responsibility
W. Edward Highsmith, Jr., editor
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date Published
c2014
Physical Description
1 online resource (xiii, 257 p. : 47 illus., 41 illus. in color)
Series Title
Molecular and translational medicine
ISBN
9781461481263 (print ed.)
9781461481270
Subjects (MeSH)
Genetic testing
Molecular Diagnostic Techniques
Abstract
Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
Contents
1. Clinical FISH Testing for the Diagnosis of Solid Tumors -- 2. Epidermal Growth Factor Receptor Testing in Lung Adenocarcinoma -- 3. The Human Epidermal Growth Factor Receptor 2 (HER2) -- 4. Tamoxifen and Irinotecan Pharmacogenomics -- 5. Hepatitis C Virus Testing -- 6. Laboratory Testing for HIV Infection: Advances after 27 years -- 7. Detection of Herpes Simplex Virus in Cerebrospinal Fluid using Real-time PCR -- 8. Toward a Safer Blood Supply: The Impact of Molecular Testing -- 9. Chromosomal Microarrays -- 10. BRCA1 and BRCA2 Testing in Inherited Breast Cancer -- 11. Cystic Fibrosis: Carrier Testing, Newborn Screening, and Diagnostic Testing -- 12. Newborn Screening by Tandem Mass Spectrometry and Molecular Confirmation -- 13. Next Generation Clinical Diagnostics: The Sequence of Events.
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e-Book
Location
Online
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