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Biomarkers for Endometriosis : State of the Art

http://libcat.nshealth.ca/permalink/provcat41842
Thomas D'Hooghe, editor. Springer , 2017.
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This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem …
Available Online
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Other Authors
D'Hooghe, Thomas
Responsibility
Thomas D'Hooghe, editor
Place of Publication
Cham
Publisher
Springer
Date Published
2017
Physical Description
1 online resource (xii, 267 pages) : 8 illus., 3 illus. in color
ISBN
9783319598543 (print ed.)
9783319598567
Subjects (MeSH)
Biomarkers
Endometriosis - diagnosis
Abstract
This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.
Contents
Building Translational Research Infrastructure and Access to Expertise for Biomarker Discovery in Cancer -- Biomarkers of Endometrial Cancer -- Biomarker Development in Chronic Inflammatory Diseases -- Endometriosis and Diagnostic Delay: The Patient’s Perspective -- Genetic Biomarkers for Endometriosis -- Epidemiological and Clinical Risk Factors for Endometriosis -- Peripheral Blood Biomarkers for Endometriosis -- Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid -- mRNA and miRNA Biomarkers for Endometriosis -- Proteomic Biomarkers for Endometriosis -- Harmonization of Clinical and Laboratory Data to Improve Biomarker Discovery in Endometriosis: WERF EPHect -- OMICs Studies and Endometriosis Biomarker Identification.
Format
e-Book
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Imaging Biomarkers : Development and Clinical Integration

http://libcat.nshealth.ca/permalink/provcat41481
Luis Martí-Bonmatí, Angel Alberich-Bayarri, editors. Springer , 2017.
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This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism…
Available Online
View e-Book
Other Authors
Alberich-Bayarri, Angel
Martí-Bonmatí, Luis
Responsibility
Luis Martí-Bonmatí, Angel Alberich-Bayarri, editors
Place of Publication
Cham
Publisher
Springer
Date Published
2017
Physical Description
1 online resource (viii, 316 pages) : 104 illus., 75 illus. in color
ISBN
9783319435022 (print ed.)
9783319435046
Subjects (MeSH)
Biomarkers
Diagnostic Imaging - methods
Image interpretation, computer-assisted
Abstract
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
Contents
1. The Shift in Paradigm to Precision Medicine in Imaging: International Initiatives for the Promotion of Imaging Biomarkers -- 2. Introduction to the Stepwise Development of Imaging Biomarkers -- 3. Defining the Biological Basis and Clinical Question (Proof of Concept); Looking for the Interrelationship (Proof of Mechanism) -- 4. Image Acquisition: Modality and Protocol Definition -- 5. MRI Preprocessing -- 6. Imaging Biomarker Structural Analysis -- 7. Imaging Biomarker Model-Based Analysis -- 8. Imaging Biomarker Measurements -- 9. Detecting Measurement Biases: Sources of Uncertainty, Accuracy, and Precision of the Measurements -- 10. Validating the Imaging Biomarker: The Proof of Efficacy and Effectiveness -- 11. The Final Step: Imaging Biomarkers in Structured Reports -- 12. Pearls and Pitfalls in Gold Standards and Biological Correlation -- 13. Imaging Biobanks, Big Data, and Population-Based Imaging Biomarkers -- 14. A Proposed Imaging Biomarkers Analysis Platform Architecture for Integration in Clinics -- 15. Use Case I: Imaging Biomarkers in Neurological Disease. Focus on Multiple Sclerosis -- 16. Use Case II: Imaging Biomarkers and New Trends for Integrated Glioblastoma Management -- 17. Use Case III: Imaging Biomarkers in Breast Tumours. Development and Clinical Integration -- 18. Use Case IV: Imaging Biomarkers in Thorax and Heart -- 19. Use Case V: Imaging Biomarkers in Musculoskeletal Disorders -- 20. Use Case VI: Imaging Biomarkers in Diffuse Liver Disease. Quantification of Fat and Iron -- 21. Imaging Biomarkers in Clinical Trials.
Format
e-Book
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