Cover -- Copyright page -- Contents -- List of contributors -- Preface -- Part One -- Section 1: Interpretation and Significance -- Chapter 1.1. What did we learn from microdialysis? -- Chapter 1.2. Microdialysis of glutamate and GABA in the brain: analysis and interpretation -- Chapter 1.3. Insights into glutamate physiology: contribution of studies utilizing in vivo microdialysis -- Chapter 1.4. The validity of intracerebral microdialysis -- Chapter 1.5. Microdialysis in the brain of anesthetized vs. freely moving animals -- Chapter 1.6. Quantitative aspects of brain microdialysis: insights from voltammetric measurements of dopamine next to microdialysis probes -- Section 2: Methods -- Chapter 2.1. New methodological aspects of microdialysis -- Chapter 2.2. Principles of quantitative microdialysis -- Chapter 2.3. Automation of blood and microdialysis sampling: combinatorial pharmacology -- Chapter 2.4. Dopamine-acetylcholine interactions in the brain studied by in vivo microdialysis -- Chapter 2.5. Microdialysis as a platform for multidisciplinary strategies -- Chapter 2.6. Ultraslow microfiltration and microdialysis for in vivo sampling: principle, techniques, and applications -- Section 3: Analytical Chemical Aspects of Microdialysis -- Chapter 3.1. Liquid chromatographic methods used for microdialysis: an overview -- Chapter 3.2. Microdialysis coupled with liquid chromatography/mass spectrometry -- Chapter 3.3. Improvement of the temporal resolution of brain microdialysis: sampling in seconds -- Chapter 3.4. In vivo peptidomics: discovery and monitoring of neuropeptides using microdialysis and liquid chromatography with mass spectrometry -- Part Two -- Section 4: Microdialysis and the Study of Behaviour -- Chapter 4.1. Microdialysis to study the effects of stress on serotonin, corticosterone and behaviour -- Chapter 4.2. Microdialysis of dopamine and norepinephrine during conditioning and operant behaviour -- Chapter 4.3. Microdialysis in the study of behavior reinforcement and inhibition -- Chapter 4.4. Changes in acetylcholine extracellular levels during cognitive processes -- Section 5: CNS Pathology Models -- Chapter 5.1. Microdialysis in genetically altered animals -- Chapter 5.2. The use of microdialysis in neuropsychiatric disease models -- Chapter 5.3. The use of microdialysis for the study of neurological disorders -- Chapter 5.4. Online glucose and lactate monitoring during physiological and pathological conditions -- Chapter 5.5. Microdialysis in pain research -- Section 6: Role of Microdialysis in Drug Development -- Chapter 6.1. The role of microdialysis in drug discovery: focus on antipsychotic agents -- Chapter 6.2. Use of microdialysis in drug discovery and development: industry and regulatory perspectives -- Chapter 6.3. The use of brain microdialysis in antidepressant drug research -- Chapter 6.4. Microdialysis as a method to study blood-brain barrier transport mechanisms -- Chapter 6.5. Assaying protein-unbound drugs using microdialysis techniques -- Chapter 6.6. Microdialysis for characterization of PK/PD relationships -- Chapter 6.7. Application of microdialysis in pharmacokinetic studies -- Section 7: Clinical Applications -- Chapter 7.1. Microdialysis in clinical drug delivery studies -- Chapter 7
Introduction : lost virtue : professional character development and medical education / Nuala Kenny and Wayne Shelton -- 1. Character formation and the making of good physicians / Edmund Pellegrino -- 2. Ethical concept of medicine as a profession : its origins in modern medical ethics and implications for physicians / Laurence B. McCullough -- 3. Character formation in professional education : a word of caution / Robert M. Veatch -- 4. Evidence-based character development / Muriel J. Bebeau -- 5. Disillusioned doctors / Carl Elliott -- 6. Molding professional character / Rosamond Rhodes and Lawrence G. Smith -- 7. Mindful practice and the tacit ethics of the moment / Ronald M. Epstein -- 8. Learning and teaching in professional character development / Karen V. Mann -- 9. Medical-social education compact and the medical learner / David J. Doukas -- 10. Searching for Doctor Good : virtues for the twenty-first century / Nuala Kenny.