Nurse Educator's Guide to Best Teaching Practice : A Case-Based Approach
https://libcat.nshealth.ca/en/permalink/provcat40309
Keeley C. Harmon, Joe Ann Clark, Jeffery M. Dyck, Vicki Moran.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book presents essential teaching skills and tools for nurse educators. It begins with a discussion of the trends in nursing education and the principles of teaching and learning. The book then explores topics such as classroom teaching, clinical experiences, teaching in the simulation laboratory, and online learning. Each chapter discusses the basics of teaching and learning in the specific environment, followed by scenarios that focus on the issues encountered by nursing faculty in these…
- Available Online
- View e-Book
- Author
- Harmon, Keeley C
- Other Authors
- Clark, Joe Ann
- Dyck, Jeffery M
- Moran, Vicki
- Responsibility
- Keeley C. Harmon, Joe Ann Clark, Jeffery M. Dyck, Vicki Moran
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiv, 140 p. : 5 illus. in color)
- ISBN
- 9783319425399
- 9783319425375 (print ed.)
- Subjects (MeSH)
- Education, Nursing - methods
- Education, Nursing - trends
- Teaching
- Abstract
- This book presents essential teaching skills and tools for nurse educators. It begins with a discussion of the trends in nursing education and the principles of teaching and learning. The book then explores topics such as classroom teaching, clinical experiences, teaching in the simulation laboratory, and online learning. Each chapter discusses the basics of teaching and learning in the specific environment, followed by scenarios that focus on the issues encountered by nursing faculty in these settings. The scenarios present the key issues under consideration, recommend actions that faculty members can institute to address the issues, and describe rationales and solutions based on best evidence. The book also includes specific tools designed to assist nurse educators in preparation for the teaching role, such as examples of course syllabi, program outcomes, clinical contracts, and action plans. Nurse Educator's Guide to Best Teaching Practice is a valuable resource for novice and experienced educators in managing the challenges inherent in nursing education.
- Contents
- 1. Issues and Trends in Nursing Education -- 2. Principles of Teaching and Learning -- 3. Classroom Teaching -- 4. Clinical Experiences -- 5. Simulation -- 6. Online Learning -- Appendix A: Example Course Syllabus -- Appendix B: Program Outcomes -- Appendix C: Exam Blueprint -- Appendix D: Example Case Study -- Appendix E: Example Welcome Letter -- Appendix F: Key Discussion Points During Advising -- Appendix G: Clinical Organization Tool -- Appendix H: Example of Clinical Syllabus -- Appendix I: Abbreviated Second Patient Form -- Appendix J: Example of a Clinical Contract -- Appendix K: Sample Action Plan -- Appendix L: Sample of Debriefing Questions for Simulation.
- Format
- e-Book
- Location
- Online
Obesity and Cancer
https://libcat.nshealth.ca/en/permalink/provcat40310
Tobias Pischon, Katharina Nimptsch, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive and up-to-date review of the relationship between obesity and cancer. It opens with a global perspective on obesity and cancer incidence, followed by in-depth discussions of those cancers for which we have sufficient evidence of a causal relationship with obesity. It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adoles…
- Available Online
- View e-Book
- Other Authors
- Pischon, Tobias
- Nimptsch, Katharina
- Responsibility
- Tobias Pischon, Katharina Nimptsch, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (viii, 256 p. : 20 illus., 8 illus. in color)
- Series Vol.
- 208
- Series Title
- Recent results in cancer research
- ISBN
- 9783319425429
- 9783319425405 (print ed.)
- ISSN
- 0080-0015
- Subjects (MeSH)
- Neoplasms - etiology
- Obesity - complications
- Risk Factors
- Abstract
- This book provides a comprehensive and up-to-date review of the relationship between obesity and cancer. It opens with a global perspective on obesity and cancer incidence, followed by in-depth discussions of those cancers for which we have sufficient evidence of a causal relationship with obesity. It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adolescent obesity, and the role of body fat distribution in cancer risk. Individual chapters discuss potential pathways for the observed associations and explore possible mechanisms from both an epidemiological and an experimental perspective. It concludes with a population perspective on the cancer risk that is attributable to obesity and is thus potentially avoidable. This book is of particular value to researchers and epidemiologists and is also of interest to public health workers and clinicians.
- Contents
- Obesity and Risk of Cancer: An Introductory Overview -- Obesity and Colorectal Cancer -- Obesity and Breast Cancer -- Obesity and Oesophageal Cancer -- Obesity and Kidney Cancer -- Obesity and Pancreatic Cancer -- Obesity and Endometrial Cancer -- Obesity and Prostate Cancer -- Obesity and Ovarian Cancer -- Obesity and Liver Cancer -- Obesity Biomarkers, Metabolism and Risk of Cancer: An Epidemiological Perspective -- Biological Mechanisms for the Effect of Obesity on Cancer Risk: Experimental Evidence -- Obesity as an Avoidable Cause of Cancer (Attributable Risks).
- Format
- e-Book
- Location
- Online
Current Concepts of Intestinal Failure
https://libcat.nshealth.ca/en/permalink/provcat40311
Risto J. Rintala, Mikko Pakarinen, Tomas Wester, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book provides readers with a succinct but comprehensive overview of current concepts relating to intestinal failure, including its treatment, with a particular focus on recent advancements. The opening chapters address basic aspects of intestinal failure, including etiology, clinical pathophysiology, physiology of intestinal adaptation, and intestinal microbiota. The complications of intestinal failure, such as bacterial overgrowth and intestinal failure-associated liver disease, are then …
- Available Online
- View e-Book
- Other Authors
- Rintala, Risto J
- Pakarinen, Mikko
- Wester, Tomas
- Responsibility
- Risto J. Rintala, Mikko Pakarinen, Tomas Wester, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (vii, 163 p. : 25 illus., 22 illus. in color)
- ISBN
- 9783319425511
- 9783319425498 (print ed.)
- Subjects (MeSH)
- Gastrointestinal Motility
- Intestines - physiopathology
- Short Bowel Syndrome - complications
- Short Bowel Syndrome - therapy
- Abstract
- This book provides readers with a succinct but comprehensive overview of current concepts relating to intestinal failure, including its treatment, with a particular focus on recent advancements. The opening chapters address basic aspects of intestinal failure, including etiology, clinical pathophysiology, physiology of intestinal adaptation, and intestinal microbiota. The complications of intestinal failure, such as bacterial overgrowth and intestinal failure-associated liver disease, are then discussed. A series of chapters specifically address important strategies in the nutritional, pharmacological, and surgical treatment of intestinal failure as well as the concept of intestinal rehabilitation. Finally, two significant emerging developments are considered: regenerative medicine and distraction enterogenesis. The authors are internationally recognized experts from Europe and North America who are ideally placed to describe current knowledge and progress in the field.
- Contents
- 1. Intestinal Failure in Children -- 2. Short Bowel Syndrome: Intestinal Adaptation -- 3. Bacterial Overgrowth and Intestinal Microbiome -- 4. Intestinal Failure-Associated Liver Disease -- 5. Recent Advances in Nutritional Care of Patients with Intestinal Failure -- 6. Short Bowel Syndrome: Pharmacological Improvement of Bowel Function and Adaptation -- 7. Modern Intestinal Rehabilitation and Outcomes -- 8. Current Concepts of Intestinal Failure: Serial Transverse Enteroplasty -- 9. Longitudinal Intestinal Lengthening -- 10. Controlled Tissue Expansion -- 11. Pediatric Small Bowel Transplantation: An Update -- 12. Intestinal Regeneration -- 13. Distraction Enterogenesis.
- Format
- e-Book
- Location
- Online
Practical Guide to Paraphilia and Paraphilic Disorders
https://libcat.nshealth.ca/en/permalink/provcat40312
Richard Balon, editor.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book is a concise, practical guide to both paraphilia and paraphilic disorders as defined by the DSM-5 guidelines. Written by experts in the field, the chapters cover the different types of paraphilic disorder as well as the cutting-edge, emerging issues such as online sex. Unlike any other book on the market, the text also covers the most successful treatment strategies, include the therapeutic, hormonal, and psychopharmacological approaches. The book also discusses the ethical, legal, an…
- Available Online
- View e-Book
- Other Authors
- Balon, Richard
- Responsibility
- Richard Balon, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 287 p. : 1 illus.)
- ISBN
- 9783319426501
- 9783319426488 (print ed.)
- Subjects (MeSH)
- Paraphilic Disorders - diagnosis
- Paraphilic Disorders - therapy
- Sexual and Gender Disorders
- Sexual Behavior
- Abstract
- This book is a concise, practical guide to both paraphilia and paraphilic disorders as defined by the DSM-5 guidelines. Written by experts in the field, the chapters cover the different types of paraphilic disorder as well as the cutting-edge, emerging issues such as online sex. Unlike any other book on the market, the text also covers the most successful treatment strategies, include the therapeutic, hormonal, and psychopharmacological approaches. The book also discusses the ethical, legal, and cultural issues that are common complications when dealing with paraphilic disorders. Many chapters feature an introduction, diagnostic criteria, summary of evidence, clinical example, recommendations, conclusion, and references. Practical Guide to Paraphilia and Paraphilic Disorders is a valuable resource for psychiatrists, psychologists, residents, and all medical professionals working with patients who may suffer from paraphilia and/or paraphilic disorders.
- Contents
- 1. Introduction to the Realm of Paraphilias -- 2. General Information: History, Etiology and Theory (e.g., Courtship), Diagnosis, Comorbidity and Prevalence -- 3. Assessment and Basic Management Principles of Paraphilic Disorders -- 4. Treatment of Paraphilic Disorders -- 5. Voyeuristic Disorder -- 6. Exhibitionistic Disorder -- 7. Frotteuristic Disorder -- 8. Sexual Masochism Disorder -- 9. Sexual Sadism Disorder -- 10. Pedophilic Disorder -- 11. Fetishistic Disorder --- 12. Transvestic Disorder -- 13. Other Specified Paraphilic Disorders -- 14 Non-paraphilic Hypersexual Disorder -- 15. Emerging Issues: Compulsive Online Sexual Behaviors -- 16. Ethics and the Therapeutic Relationship in the Care of People Living with Paraphilic Disorders -- 17. Legal Issues Involved in the Management of Paraphilic Disorders -- 18. Cultural Aspects of Unusual Sexual Interests.
- Format
- e-Book
- Location
- Online
Targeting Autophagy in Cancer Therapy
https://libcat.nshealth.ca/en/permalink/provcat40313
Jin-Ming Yang, editor.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the v…
- Available Online
- View e-Book
- Other Authors
- Yang, Jin-Ming
- Responsibility
- Jin-Ming Yang, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (vii, 141 p. : 12 illus., 10 illus. in color)
- Series Title
- Current cancer research
- ISBN
- 9783319427409
- 9783319427386 (print ed.)
- ISSN
- 2199-2584
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Autophagy - drug effects
- Neoplasms - genetics
- Neoplasms - therapy
- Abstract
- This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research. This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.
- Contents
- 1. Autophagy as a Therapeutic Target in Cancer -- 2. Autophagy in Cancer Cells vs. Cancer Tissues: Two Different Stories -- 3 .Small-Molecule Regulators of Autophagy as Potential Anti-cancer Therapy -- 4. Regulation of Autophagy by microRNAs: Implications in Cancer Therapy -- 5. Targeting PI3-Kinases in Modulating Autophagy and Anti-cancer Therapy -- 6. Adult and Cancer Stem Cells: Perspectives on Autophagic Fate Determinations and Molecular Intervention -- 7. Role of Autophagy in Tumor Progression and Regression.
- Format
- e-Book
- Location
- Online
Atlas of Ocular Anatomy
https://libcat.nshealth.ca/en/permalink/provcat40314
Mohammad Wakeel Ansari, Ahmed Nadeem.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book is a practical and concise atlas on ocular anatomy, with an emphasis on applied aspects and hints for easy retention strategies. The vast color illustrations and photographs consist of self-explanatory, precise, and meaningful representations of the points covered in the text. Covering chapters such as bony socket of the eye, extraocular muscles, eyelids, cornea and lens, and neurology of the eye, Atlas of Ocular Anatomy gives a summary of the important and relevant points for each to…
- Available Online
- View e-Book
- Author
- Ansari, Mohammad Wakeel
- Other Authors
- Nadeem, Ahmed
- Responsibility
- Mohammad Wakeel Ansari, Ahmed Nadeem
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 106 p. : 89 illus., 88 illus. in color)
- ISBN
- 9783319427812
- 9783319427805 (print ed.)
- Subjects (MeSH)
- Eye - anatomy & histology
- Ocular Physiological Phenomena
- Orbit - anatomy & histology
- Abstract
- This book is a practical and concise atlas on ocular anatomy, with an emphasis on applied aspects and hints for easy retention strategies. The vast color illustrations and photographs consist of self-explanatory, precise, and meaningful representations of the points covered in the text. Covering chapters such as bony socket of the eye, extraocular muscles, eyelids, cornea and lens, and neurology of the eye, Atlas of Ocular Anatomy gives a summary of the important and relevant points for each topic, separating out the essential from the nonessential elements. Complete with representative schematic line diagrams and full color photographs, this atlas features the correlation between anatomic facts with their probable clinical presentations in disease.
- Contents
- 1. Anatomy of the Orbit -- 2. The Eyeball: Some Basic Concepts -- 3. The Blood Supply of the Eyeball -- 4. Extraocular and Intraocular Muscles -- 5. Anatomy of the Eyelids -- 6. Transparent Structures of the Eyeball Cornea, Lens, and Vitreous -- 7. The Lacrimal Apparatus -- 8. Neurophthalmology: Neuromuscular Control of the Eyeball -- 9. Congenital Anomalies of Eye.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
The Infected Eye : Clinical Practice and Pathological Principles
https://libcat.nshealth.ca/en/permalink/provcat40315
Nora V. Laver, Charles S. Specht, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book addresses the diagnosis and treatment of common ocular infections. Relevant pathological principles are described to provide a basis for the understanding of these disorders. The epidemiology of infection as a class of ocular disease and the pathological effects of infectious processes in tissue are discussed in introductory chapters. These fundamentals are explained and reinforced with tables and selected illustrations of tissue pathology. Further chapters by leading clinical special…
- Available Online
- View e-Book
- Other Authors
- Laver, Nora V
- Specht, Charles S
- Responsibility
- Nora V. Laver, Charles S. Specht, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (x, 237 p. : 67 illus., 64 illus. in color)
- ISBN
- 9783319428406
- 9783319428383 (print ed.)
- Subjects (MeSH)
- Eye Infections
- Abstract
- This book addresses the diagnosis and treatment of common ocular infections. Relevant pathological principles are described to provide a basis for the understanding of these disorders. The epidemiology of infection as a class of ocular disease and the pathological effects of infectious processes in tissue are discussed in introductory chapters. These fundamentals are explained and reinforced with tables and selected illustrations of tissue pathology. Further chapters by leading clinical specialists describe recommended approaches to infections of the eye and periocular tissues as these conditions occur in adults and children. Illustrative tables and algorithms enhance the discussion, making key principles accessible to the busy clinician. The final chapters provide a guide to relevant microbiological techniques, recommendations for specimen collection and transport, and a survey of antimicrobial therapy for the care of patients with ocular infectious diseases.
- Contents
- 1. Epidemiology and Clinical Significance of Ocular Infection -- 2. Pathogenic properties of infectious organisms and tissue reactions -- 3. Ocular infection worldwide -- 4. Conjunctivitis -- 5. Corneal infection and ulceration -- 6. Intraocular infection -- 7. Infections of the eyelids, orbit and ocular adnexa -- 8. Ocular infection in children -- 9. Anti-infective therapy for ocular infection -- 10. Specimen collection and laboratory methods for ocular infection.
- Format
- e-Book
- Location
- Online
Ketamine for Treatment-Resistant Depression : The First Decade of Progress
https://libcat.nshealth.ca/en/permalink/provcat40316
Sanjay J. Mathew, Carlos A. Zarate, Jr., editors.
--Cham:
Springer International Publishing : Imprint: Adis
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation "ketamine-like" fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of seve…
- Available Online
- View e-Book
- Other Authors
- Mathew, Sanjay J
- Zarate, Jr., Carlos A
- Responsibility
- Sanjay J. Mathew, Carlos A. Zarate, Jr., editors
- Place of Publication
- Cham
- Publisher
- Springer International Publishing : Imprint: Adis
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xix, 155 p. : 6 illus., 3 illus. in color)
- ISBN
- 9783319429250
- 9783319429236 (print ed.)
- Subjects (MeSH)
- Antidepressive Agents
- Depressive Disorder, Major - drug therapy
- Depressive Disorder, Treatment-Resistant - drug therapy
- Ketamine - therapeutic use
- Abstract
- This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation "ketamine-like" fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine's psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine's rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine's rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.
- Contents
- 1. The History of Ketamine Use and Its Clinical Indications -- 2. The Basic and Clinical Pharmacology of Ketamine -- 3. Ketamine: Clinical Studies in Treatment- Resistant Depressive Disorders -- 4. Ketamine and Suicide Risk -- 5. Ketamine: Its Safety, Tolerability, and Impact on Neurocognition -- 6. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies -- 7. Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies -- 8. Ketamine and Electroconvulsive Therapy -- 9. Emerging Data for Ketamine in Obsessive-Compulsive, Stress-Related, and Substance Use Disorders.
- Format
- e-Book
- Location
- Online
STAT Inhibitors in Cancer
https://libcat.nshealth.ca/en/permalink/provcat40318
Alister C. Ward, editor.
--Cham:
Springer International Publishing : Imprint: Humana Press
, c2016.
- Available Online
- View e-Book
- Location
- Online
This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to i…
- Available Online
- View e-Book
- Other Authors
- Ward, Alister C
- Responsibility
- Alister C. Ward, editor
- Place of Publication
- Cham
- Publisher
- Springer International Publishing : Imprint: Humana Press
- Date of Publication
- c2016
- Physical Description
- 1 online resource (vii, 195 p. : 11 illus. in color)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9783319429496
- 9783319429472 (print ed.)
- ISSN
- 2196-9906
- Subjects (MeSH)
- Antineoplastic Agents - pharmacology
- Neoplasms - drug therapy
- Protein Inhibitors of Activated STAT
- STAT Transcription Factors - antagonists & inhibitors
- Abstract
- This volume, which includes contributions from leading scientists and clinicians in the field, provides definitive, state-of-the-art information on STAT inhibitors in a biological and clinical context. It gives an overview of the biology of the STAT family of transcription factors and their role in cancer etiology. Additionally, it describes the raft of therapeutic approaches being used to inhibit STATs in the context of various cancers, covering the full spectrum of therapeutic approaches to inhibiting STATs, and presenting emerging data from clinical trials.
- Contents
- 1. STATs in Health and Disease -- 2. STAT Proteins in Cancer -- 3. Translating STAT Inhibitors from the Lab to the Clinic -- 4. Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials -- 5. STAT3 Inhibitors in Cancer: A Comprehensive Update -- 6. Targeting Upstream Janus Kinases -- 7. Inhibitors of Upstream Inducers of STAT Activation.
- Format
- e-Book
- Location
- Online
Cardiac Biomarkers : Case Studies and Clinical Correlations
https://libcat.nshealth.ca/en/permalink/provcat40319
Alan S. Maisel, Allan S. Jaffe, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book presents a comprehensive compendium of case studies to inform clinicians how to optimally deploy the major clinically utilized biomarkers in cardiology. Biomarkers now play an integral role in the treatment and management of patients with congestive heart failure and acute ischemic heart disease because they provide crucial information about the status of individual patients. For that reason, it is important for clinicians to understand the basis for the use of these markers. Every re…
- Available Online
- View e-Book
- Other Authors
- Maisel, Alan S
- Jaffe, Allan S
- Responsibility
- Alan S. Maisel, Allan S. Jaffe, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xviii, 370 p. : 56 illus., 40 illus. in color)
- ISBN
- 9783319429823
- 9783319429809 (print ed.)
- Subjects (MeSH)
- Biomarkers
- Heart Failure
- Myocardial Ischemia
- Natriuretic Peptides - therapeutic use
- Troponin - therapeutic use
- Abstract
- This book presents a comprehensive compendium of case studies to inform clinicians how to optimally deploy the major clinically utilized biomarkers in cardiology. Biomarkers now play an integral role in the treatment and management of patients with congestive heart failure and acute ischemic heart disease because they provide crucial information about the status of individual patients. For that reason, it is important for clinicians to understand the basis for the use of these markers. Every reader may not have the laboratory and/or clinical expertise to understand all the details associated with the use of these markers, which is why this book takes a case oriented approach and by doing so provides a practical resource to guide the clinician through the options available. Cardiac Biomarkers discusses how to use these biomarkers optimally and, in particular, how to understand when values provide actionable information. The book an essential guide for all physicians and healthcare practitioners in the field of cardiology.
- Contents
- [publisher supplied] The patient with chest pain: The troponin story -- Troponin Basics for the clinician -- Pathophysiology of trop I and T in myocardial ischemia/infarction -- International Definition of MI- rationale and practice -- Evaluation of patients presenting with chest pain- where do troponins fit in -- Using contemporary troponin in patients with AMI -- Using troponins to guide therapy in ACS -- Use of cTn in patients with heart failure -- Elevated cTn in other acute situations -- Use of cTn for detection of more chronic disease states -- High sensitivity assays- what are they and why do we need them -- Use of troponin for the evaluation of patients potentially at risk for cardiovascular disease -- Gaps in our biomarker armamentarium: what novel biomarkers might be synergistic in patients with acute disease -- The patient with shortness of breath: the natriuretic peptide story -- Evaluation of patients presenting with sob- where do nps fit in -- Pathophysiology of bnp, and ntpro bnp -- A clinicians guide to lab assays for nps -- Using NPS in the ED- diagnosis -- Using NPs in the ED- algorithms and risk stratification -- Using NPs in the hospital -- NPs at the time of discharge -- Finger stick NP levels at home -- Guiding therapy of heart failure with NPs -- Caveats to NP measurement -- Other biomarkers for heart failure -- Biomarkers of cardiorenal disease -- Biomarkers of cardiac risk.
- Format
- e-Book
- Publication Type
- Case Reports
- Location
- Online
Disordered Vertebral and Rib Morphology in Pudgy Mice : Structural Relationships to Human Congenital Scoliosis
https://libcat.nshealth.ca/en/permalink/provcat40320
Frederic Shapiro.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congeni…
- Available Online
- View e-Book
- Author
- Shapiro, Frederic
- Responsibility
- Frederic Shapiro
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (ix, 123 p. : 20 illus., 15 illus. in color)
- Series Vol.
- 221
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319431512
- 9783319431499 (print ed.)
- ISSN
- 0301-5556
- Subjects (MeSH)
- Mice - abnormalities
- Scoliosis
- Spine - abnormalities
- Abstract
- This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
- Contents
- [publisher supplied] I. INTRODUCTION -- II. MATERIALS AND METHODS -- 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations -- 3. Radiographic studies -- 4. Histologic studies -- 5. Computerized three-dimensional reconstructions -- 6. Previous studies on chick vertebral development and human congenital scoliosis -- III. RESULTS -- 1. Gross appearance -- 2. Whole mount appearances -- 3. Radiographic studies -- 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia -- 5. Computerized three-dimensional reconstructions -- 6. Chick embryo vertebral development -- 7. Radiology and histopathology of human congenital scoliosis spine -- IV. DISCUSSION -- ion -- 3. The pudgy mouse -- 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation -- 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities -- 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies -- V. CONCLUSIONS -- 1. Implications of pudgy vertebral abnormalities for biologic research -- 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. .
- Format
- e-Book
- Location
- Online
The Ulnar Nerve : Sensory and Motor Conduction Studies
https://libcat.nshealth.ca/en/permalink/provcat40321
Giuliano Gentili, Mario Di Napoli.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book systematically reviews sensory and motor nerve conduction studies on the ulnar nerve, from pilot human studies of peripheral nerve conduction in the 1950s through to the most recent scientific evidence. Precise descriptions are provided of approx. 70 nerve conduction techniques that were reproduced in the laboratory, with organization of the techniques according to practical criteria for ease of reference. Particular attention is devoted to those techniques that have shown higher sens…
- Available Online
- View e-Book
- Author
- Gentili, Giuliano
- Other Authors
- Di Napoli, Mario
- Responsibility
- Giuliano Gentili, Mario Di Napoli
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xxxiii, 503 p. : 294 illus.)
- ISBN
- 9783319432922
- 9783319432915 (print ed.)
- Subjects (MeSH)
- Neural Conduction - physiology
- Sensation - physiology
- Ulnar Nerve - physiology
- Ulnar Neuropathies - diagnosis
- Abstract
- This book systematically reviews sensory and motor nerve conduction studies on the ulnar nerve, from pilot human studies of peripheral nerve conduction in the 1950s through to the most recent scientific evidence. Precise descriptions are provided of approx. 70 nerve conduction techniques that were reproduced in the laboratory, with organization of the techniques according to practical criteria for ease of reference. Particular attention is devoted to those techniques that have shown higher sensitivity and specificity in diagnosis of compressive mononeuropathies, such as ulnar neuropathy at the elbow or wrist. Normal and pathological values derived from the original articles and the subsequent literature are presented, and the wealth of illustrative material facilitates comprehension and reproduction of each technique. The volume is completed by a detailed, well-illustrated glossary explaining the more commonly used terms in electrodiagnostic medicine. This book will appeal to novice and experienced neurologists, students, clinical neurophysiology technicians, and rehabilitation physicians. It represents a logical extension of the volumes on the median nerve published by Springer.
- Contents
- List of Abbreviations -- Introduction Synoptic Table -- Sensory Conduction Studies Index (by Practical Criteria) -- Motor Conduction Studies Index (by Practical Criteria) -- Part I. Sensory Conduction Studies -- S1 Digit V: Wrist, Elbow -- S2 Digit V: Wrist, Above Elbow; Wrist: Elbow; Elbow: Axilla -- S3 Digit V: Wrist, Elbow, Axilla; Wrist: Elbow, Axilla -- S4 Digit IV, V: Wrist, Elbow; Digit IV, V: Wrist -- S5 Wrist, Elbow: Digit IV, V; Wrist: Digit IV, V -- S6Digit V: Wrist, Below Elbow, Above Elbow -- S7 Digit II, V: Wrist -- S8 Wrist, Elbow: Digit V -- S9 Wrist: Digit II, V -- S10 Digit V: Palm, Wrist, Elbow; Wrist: Elbow, Axilla -- S11 Digit I, II, III, V: Wrist -- S12 Wrist, Palm: Digit II, V -- S13 Wrist: Dorsal Hand -- S14 Forearm: Dorsal Hand; Dorsal Hand: Forearm -- S15 Wrist, Below Elbow, Above Elbow, Upper Arm: Digit V -- S16 Wrist, Below Elbow, Above Elbow, Axilla: Digit V -- S17 Wrist: Arm, Axilla; Below Elbow: Axilla; Digit V: Arm -- S18 Forearm: Dorsal Hand -- S19 Wrist, Below Elbow, Above Elbow: Digit V -- S20 Palm: Distal Forearm, Elbow -- S21 Wrist, Below Elbow, Above Elbow: Digit V; Digit V: Wrist, Below Elbow, Above Elbow; Wrist: Below Elbow, Above Elbow -- S22 Wrist: Above Elbow -- S23 Wrist: Elbow; Elbow: Axilla -- S24 Wrist, Below Elbow, Above Elbow: Digit V -- Part II. Motor Conduction Studies -- M1 Wrist, Elbow, Axilla: Hand -- M2Elbow, Wrist: Hand -- M3 Wrist, Below Elbow, Above Elbow, Mid-Arm, Axilla: Hand -- M4 Wrist, Above Elbow: Hand -- M5 Wrist, Above Elbow, Axilla: Hand -- M6 Axilla, Above Elbow, Mid-Forearm, Wrist: Hand -- M7 Axilla, Elbow, Wrist: Hand -- M8 Wrist, Lower Forearm, Upper Forearm, Elbow, Arm: Hand -- M9 Axilla, Above Elbow, Wrist: Hand -- M10 Wrist, Elbow: Hand -- M11 Wrist, Below Elbow, Above Elbow, Axilla: Hand -- M12 Wrist, Below Elbow, Elbow, Above Elbow, ErbÇÖs Point: Hand -- M13 Wrist: Hand -- M14 Axilla, Above Sulcus, Below Sulcus, Wrist: Hand; Above Sulcus: Forearm -- M15 Wrist, Elbow, Arm: Hand -- M16 Wrist: Hand; Elbow: Hand; Axilla: Hand -- M17 Axilla, Above Elbow, Below Elbow, Wrist: Hand -- M18 Wrist, Elbow, Above Elbow, Erb's Point: Hand -- M19 Wrist, Elbow: Hand -- M20 Axilla, Above Elbow, Below Elbow, Wrist: Hand -- M21 Wrist: Hand; Elbow: Hand -- M22 Wrist: Hand -- M23Elbow, Wrist, Palm: Hand -- M24 Wrist, Elbow, Axilla, Erb's Point: Hand -- M25 Above Sulcus, Below Sulcus, Wrist: Hand -- M26 Axilla, Above Elbow, Below Elbow, Wrist: Hand; Above Elbow to Below Elbow: Hand -- M27 Wrist, Below Elbow, Above Elbow, Upper Arm: Hand; Upper Arm, Above Elbow: Forearm -- M28 Wrist: Hand -- M29 Wrist, Elbow, Above Elbow: Hand; Elbow, Above Elbow: Forearm -- M30 Wrist, Below Elbow, Above Elbow, Axilla: Hand -- M31 Wrist: Hand -- M32 Wrist: Hand -- M33 Below Elbow to Above Elbow: Hand -- M34 Below Elbow to Above Elbow: Hand -- M35 Below Elbow, Above Elbow: Forearm; Wrist, Below Elbow, Above Elbow: Hand -- M36 Above Wrist to Below Wrist: Hand -- M37 Palm, Wrist, Above Elbow, Axilla, Erb's Point: Hand -- M38 Palm, Wrist: Hand; Palm, Wrist, Below Elbow, Above Elbow: Hand -- M39 Below Elbow to Above Elbow: Forearm; Below Elbow to Above Elbow: Hand -- M40 Wrist: Hand -- M41 Wrist, Below Elbow, Above Elbow: Hand -- M42 Wrist, Below Elbow, Above Elbow: Hand -- M43 Below Elbow, Above Elbow: Hand -- M44 Wrist: Hand -- Glossary.
- Format
- e-Book
- Location
- Online
Consent in Pediatric Urology
https://libcat.nshealth.ca/en/permalink/provcat40322
Prasad Godbole, Duncan T. Wilcox, Martin A. Koyle, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This comprehensive handbook of consent in surgical subspecialities is dedicated to the risks and complications that a child needs to be consented for in the vast majority of pediatric surgical procedures with evidence base and outcomes. The chapters address common and rare complications encountered in pediatric subspeciality practice which clinicians need to be aware of to allow them to take fully informed consent. The contributors are renowned for their expertise in pediatric urology and provi…
- Available Online
- View e-Book
- Other Authors
- Godbole, Prasad
- Wilcox, Duncan T
- Koyle, Martin A
- Responsibility
- Prasad Godbole, Duncan T. Wilcox, Martin A. Koyle, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 299 p. : 28 illus., 20 illus. in color)
- ISBN
- 9783319435275
- 9783319435268 (print ed.)
- ISSN
- 2509-9604
- Subjects (MeSH)
- Parental Consent
- Urologic Surgical Procedures
- Abstract
- This comprehensive handbook of consent in surgical subspecialities is dedicated to the risks and complications that a child needs to be consented for in the vast majority of pediatric surgical procedures with evidence base and outcomes. The chapters address common and rare complications encountered in pediatric subspeciality practice which clinicians need to be aware of to allow them to take fully informed consent. The contributors are renowned for their expertise in pediatric urology and provide evidence and outcome based areas for consent in the first book of the series: Consent in Pediatric Urology.
- Contents
- Part I. Introduction -- 1. Why and how is consent obtained? -- Part II. Open surgery of the upper urinary tract -- 2. Open Nephrectomy -- 3. Partial nephrectomy -- 4. Urtereopelvic junction obstruction -- 5. Antireflux surgery -- 6. Open Ureteral surgery: ureteroureterostomy and Transureteroureterostomy -- Part III. Surgery of the bladder -- 7. Epispadias and bladder exstrophy -- Part IV. Endoscopic surgery of the urinary tract -- 8. Cystoscopy and cystoscopic interventions -- 9. Minimally invasive interventions for stone disease -- 10. General laparoscopy -- 11. Laparoscopic surgery of the upper urinary tract -- 12. Robot-assisted Laparoscopic ureteral reimplantation -- Part V. Genitalia -- 13. Hydrocele and Hernia -- 14. Orchidopexy and orchidectomy -- 15. Laparoscopic orchidopexy -- 16. Varicocelectomy -- 17. Consent for Circumcision -- 18. Hypospadias Repair -- 19. Surgery for correction of disorders of sex development -- 20. Surgery for Persistent cloaca -- Part VI. Renal Impairment Surgery -- 21. Hemodialysis and peritoneal dialysis -- 22. Kidney transplantation -- Part VII. Urogenital Tumours -- 23. Wilm's tumour and other renal neoplasms -- 24. Bladder and/or Prostate Rhabdomyosarcoma. 25. Testicular and Paratesticular tumors of Children and Adolescents -- Part VIII. Trauma -- 26. Genital trauma -- 27. Urinary tract trauma -- Part IX. Surgery for urinary incontinence -- 28. Augmentation Cystoplasty and Diversion -- 29. Appendicovesicostomy and ileovesicostomy -- 30. Informed Consent Prior to Malone Antegrade Continence Enema: Surgery for Fecal Incontinence.
- Format
- e-Book
- Location
- Online
Homeopathy, The Undiluted Facts : Including a Comprehensive A-Z Lexicon
https://libcat.nshealth.ca/en/permalink/provcat40323
Edzard Ernst.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book traces the genesis, principles and practice of homeopathy, and discusses the reasons for its enduring popularity. Two hundred years ago, medicine had little to offer except blood letting and the administration of violent purgatives--practices which shortened the course of illness by hastening the death of the patient. Largely in reaction to what he correctly saw as the brutality and ineffectiveness of the medicine of his day, the eighteenth century German physician Samuel Hahnemann de…
- Available Online
- View e-Book
- Author
- Ernst, Edzard
- Responsibility
- Edzard Ernst
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (x, 151 p. : 27 illus., 18 illus. in color)
- ISBN
- 9783319435923
- 9783319435909 (print ed.)
- Subjects (MeSH)
- Homeopathy
- Abstract
- This book traces the genesis, principles and practice of homeopathy, and discusses the reasons for its enduring popularity. Two hundred years ago, medicine had little to offer except blood letting and the administration of violent purgatives--practices which shortened the course of illness by hastening the death of the patient. Largely in reaction to what he correctly saw as the brutality and ineffectiveness of the medicine of his day, the eighteenth century German physician Samuel Hahnemann developed a system of therapeutics that he termed homeopathy. Ironically, while modern medicine has changed beyond recognition, homeopathy, with its roots in alchemy and metaphysics, continues to be practiced precisely as it was in Hahnemann's day. Readers of this book will enjoy the story of homeopathy and its almost magical attraction, whilst learning much from the authors' rational and scientific discussion of the biological, chemical and psychological questions that this treatment raises.
- Contents
- Part I: The Facts of the Matter -- Introduction -- Definition and Main Principles of Homeopathy -- Myths about Homeopathy -- Current Popularity, Acceptance, and Regulation of Homeopathy -- History of Homeopathy -- Different Types of Homeopathy and Homeopaths -- The Patients of Homeopaths -- Homeopathy as a Criticism of Conventional Medicine -- Scientific Evidence -- Spurious Arguments for and Counter-Arguments against Homeopathy -- Part II: Lexicon of Homeopathy.
- Format
- e-Book
- Publication Type
- Popular Works
- Location
- Online
Building a Culture of Health : A New Imperative for Business
https://libcat.nshealth.ca/en/permalink/provcat40324
John A. Quelch, Emily C. Boudreau.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This ambitious volume sets out to understand how every company impacts public health and introduces a robust model, rooted in organizational and scientific knowledge, for companies committed to making positive contributions to health and wellness. Focusing on four interconnected areas of corporate impact, it not only discusses the business imperative of promoting a healthier society and improved living conditions worldwide, but also provides guidelines for measuring a company's population healt…
- Available Online
- View e-Book
- Author
- Quelch, John A
- Other Authors
- Boudreau, Emily C
- Responsibility
- John A. Quelch, Emily C. Boudreau
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 174 p. : 22 illus. in color)
- Series Title
- SpringerBriefs in public health
- ISBN
- 9783319437231
- 9783319437224 (print ed.)
- ISSN
- 2192-3698
- Subjects (MeSH)
- Environmental Health
- Health Promotion - methods
- Occupational Health
- Organizational Culture
- Preventive Health Services - organization & administration
- Public health practice
- Abstract
- This ambitious volume sets out to understand how every company impacts public health and introduces a robust model, rooted in organizational and scientific knowledge, for companies committed to making positive contributions to health and wellness. Focusing on four interconnected areas of corporate impact, it not only discusses the business imperative of promoting a healthier society and improved living conditions worldwide, but also provides guidelines for measuring a company's population health footprint. Examples, statistics and visuals showcase emerging corporate involvement in public health and underscore the business opportunities available to companies that invest in health. The authors offer a detailed roadmap for optimizing health-promoting actions in a rapidly evolving business and social climate across these core areas: Planning and building a culture of health. Consumer health: How organizations affect the safety, integrity, and healthfulness of the products and services they offer to their customers and end consumers. Employee health: How organizations affect the health of their employees (e.g., provision of employer-sponsored health insurance, workplace practices and wellness programs). Community health: How organizations affect the health of the communities in which they operate and do business. Environmental Health: How organizations' environmental policies (or lack thereof) affect individual and population health. Implementing and sustaining a culture of health. Building a Culture of Health clarifies both a mission and a vision for use by MPH and MBA students in health management, professors in schools of public health and business schools, and business leaders and chief medical officers in health care and non-health care businesses.
- Contents
- 1. Building a Culture of Health -- 2. Consumer Health -- 3. Employee Health -- 4. Community Health -- 5. Environmental Health -- 6. Implementing a Culture of Health.
- Format
- e-Book
- Location
- Online
Secondary Analysis of Electronic Health Records
https://libcat.nshealth.ca/en/permalink/provcat40325
MIT Critical Data.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Access
- Open access
- Location
- Online
This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of med…
- Available Online
- View e-Book
- Corporate Author
- MIT Critical Data
- Responsibility
- MIT Critical Data
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xxi, 427 p. : 108 illus., 100 illus. in color)
- ISBN
- 9783319437422
- 9783319437408 (print ed.)
- Subjects (MeSH)
- Data Anonymization
- Data Curation
- Electronic Health Records
- Quality Control
- Specialty
- Health Services Research
- Medical Informatics
- Abstract
- This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a "data desert" when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.
- Contents
- Part I. Setting the Stage: Rationale Behind and Challenges to Health Data Analysis -- 1. Objectives of the Secondary Analysis of Electronic Health Record Data -- 2. Review of Clinical Databases -- 3. Challenges and Opportunities in Secondary Analyses of Electronic Health Record Data -- 4. Pulling It All Together: Envisioning a Data-Driven, Ideal Care System -- 5. The Story of MIMIC -- 6. Integrating Non-clinical Data with EHRs -- 7. Using EHR to Conduct Outcome and Health Services Research -- 8. Residual Confounding Lurking in Big Data: A Source of Error -- Part II. A Cookbook: From Research Question Formulation to Validation of Findings -- 9. Formulating the Research Question -- 10. Defining the Patient Cohort -- 11. Data Preparation -- 12. Data Pre-processing -- 13. Missing Data -- 14. Noise Versus Outliers -- 15. Exploratory Data Analysis -- 16. Data Analysis -- 17. Sensitivity Analysis and Model Validation -- Part III. Case Studies Using MIMIC -- 18. Trend Analysis: Evolution of Tidal Volume Over Time for Patients Receiving Invasive Mechanical Ventilation -- 19. Instrumental Variable Analysis of Electronic Health Records -- 20. Mortality Prediction in the ICU Based on MIMIC-II Results from the Super ICU Learner Algorithm (SICULA) Project -- 21. Mortality Prediction in the ICU -- 22. Data Fusion Techniques for Early Warning of Clinical Deterioration -- 23. Comparative Effectiveness: Propensity Score Analysis -- 24. Markov Models and Cost Effectiveness Analysis: Applications in Medical Research -- 25. Blood Pressure and the Risk of Acute Kidney Injury in the ICU: Case-Control Versus Case-Crossover Designs -- 26. Waveform Analysis to Estimate Respiratory Rate -- 27. Signal Processing: False Alarm Reduction -- 28. Improving Patient Cohort Identification Using Natural Language Processing -- 29. Hyperparameter Selection.
- Access
- Open access
- Format
- e-Book
- Location
- Online
Fundamentals of Pediatric Drug Dosing
https://libcat.nshealth.ca/en/permalink/provcat40326
Iftekhar Mahmood, Gilbert Burckart, editors.
--Cham:
Springer International Publishing : Imprint: Adis
, c2016.
- Available Online
- View e-Book
- Location
- Online
Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource. With the advent of pediatric exclusivity, and requirements to conduct clinical studies in chil…
- Available Online
- View e-Book
- Other Authors
- Mahmood, Iftekhar
- Burckart, Gilbert
- Responsibility
- Iftekhar Mahmood, Gilbert Burckart, editors
- Place of Publication
- Cham
- Publisher
- Springer International Publishing : Imprint: Adis
- Date of Publication
- c2016
- Physical Description
- 1 online resource (viii, 146 p. : 12 illus. in color)
- ISBN
- 9783319437545
- 9783319437521 (print ed.)
- Subjects (MeSH)
- Pediatrics - methods
- Pharmacokinetics
- Pharmacology - methods
- Dose-Response Relationship, Drug
- Abstract
- Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource. With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children. Children are not "small adults", and drug dosing in this population requires special consideration. There are subtle physiological and biochemical differences among neonates, infants, children, adolescents and adults and dosing in pediatrics requires proper understanding of these factors. Furthermore, dosing in children, as in adults, should be based on pharmacokinetic and pharmacodynamic data. This is an evolving area, as pediatric pharmacokinetic studies are becoming mandatory for getting approval of new drugs in this population.
- Contents
- 1. Pediatric Drug Development and the Regulatory Changes that are Creating the Science of Pediatric Dosing -- 2. Pediatric Physiology -- 3. Developmental Pharmacology: Impact on Pharmacokinetics and Pharmacodynamics of Drugs -- 4. Pediatric Clinical Trial Design and Dosing -- 5. Applicaton of Allometric Principles in Pediatric Drug Development -- 6. Population Pharmacokinetics in Pediatric Drug Development -- 7. Scaling Dose-Exposure-Response from Adults to Children -- 8. Applications of Physiologically-Based Pharmacokinetic (PBPK) Models for Pediatric Populations -- 9. Perinatal Pharmacology and Maternal/Fetal Dosing.
- Format
- e-Book
- Location
- Online
Care of Adults with Chronic Childhood Conditions : A Practical Guide
https://libcat.nshealth.ca/en/permalink/provcat40327
Mariecel Pilapil, David E. DeLaet, Alice A. Kuo, Cynthia Peacock, Niraj Sharma, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book addresses the unique healthcare needs of adults with chronic childhood illnesses. It presents a model of primary and secondary prevention for emerging adulthood: primary prevention in which all young adults are screened for high-risk behaviors and health needs and secondary prevention in which young adults with chronic childhood conditions are optimized through coordinated care, connections to community resources and social/family support. This book is organized in five parts. Part I …
- Available Online
- View e-Book
- Responsibility
- Mariecel Pilapil, David E. DeLaet, Alice A. Kuo, Cynthia Peacock, Niraj Sharma, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xxvi, 436 p. : 10 illus., 9 illus. in color)
- ISBN
- 9783319438276
- 9783319438252 (print ed.)
- Subjects (MeSH)
- Chronic Disease - therapy
- Transition to Adult Care
- Abstract
- This book addresses the unique healthcare needs of adults with chronic childhood illnesses. It presents a model of primary and secondary prevention for emerging adulthood: primary prevention in which all young adults are screened for high-risk behaviors and health needs and secondary prevention in which young adults with chronic childhood conditions are optimized through coordinated care, connections to community resources and social/family support. This book is organized in five parts. Part I provides a detailed overview of the health care transition from pediatrics to adult medicine from both a policy and practice perspective. In Part II, the concept of emerging adulthood as a developmental period is explored and strategies for providing improved comprehensive care for this age group are discussed. Part III reviews specific chronic childhood conditions, such as attention-deficit/hyperactivity disorder, autism, cystic fibrosis, and diabetes mellitus, and offers clinical cases and summary reports that can be used as a quick guides to each condition. In Part IV, additional clinical considerations that are not necessarily condition-specific but are highly relevant to the care of young adults with chronic childhood conditions are examined. Part V describes the socio-legal issues involved in caring for this population. Care of Adults with Chronic Childhood Conditions provides primary care providers with a new framework for the care of young adults and identifies opportunities to influence patient health outcomes over a life trajectory.
- Contents
- Part I. Facilitating the Transition from Pediatric-Oriented to Adult-Oriented Primary Care -- Facilitating the Transition from Pediatric-Oriented to Adult-Oriented Primary Care -- Part II. Care of the Emerging Adult -- Care of the Emerging Adult -- Part III. Case-Based Examples of Management of the Young Adult with a Chronic Childhood Condition -- Attention-Deficit/Hyperactivity Disorder (ADHD) -- Autism -- Cerebral Palsy -- Childhood and Adolescent Cancer Survivors -- Congenital Heart Disease -- Cystic Fibrosis -- Diabetes Mellitus (Type 1) -- Down Syndrome -- Human Immunodeficiency Virus (HIV) -- Inflammatory Bowel Disease -- Intellectual Disability -- Juvenile Idiopathic Arthritis -- Muscular Dystrophy -- Sickle Cell Disease -- Solid Organ Transplantation -- Spina Bifida -- Part IV. Other Clinical Considerations in the Care of Adults with Chronic Childhood Conditions -- Respiratory Care of Adults with Chronic Pulmonary Disease -- Nutritional Support -- Technology Dependence of the Nervous System -- Mobility Impairment -- Sexual and Reproductive Health -- Palliative Care -- Part V. Socio-Legal Aspects of Transition Care -- Assessing and Enhancing Psychosocial Functioning -- Adherence and Self-Management -- Education -- Employment -- Independent Living -- Decision-Making and Guardianship -- Access to Health Insurance.
- Format
- e-Book
- Location
- Online
Drug Dosing in Obesity. Volume I, Antimicrobials
https://libcat.nshealth.ca/en/permalink/provcat40328
Syed Tabish R. Zaidi, Jason A. Roberts, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book provides an up to date review on antimicrobials dosing in obese patients, including practice recommendations for clinical use. The book is written by a group of doctors and pharmacists working in infectious diseases practice and research. The introductory chapter outlines the important physiological changes in obesity including factors affecting the dosing of antimicrobials in obese patients. The introductory chapter is followed by ten chapters covering the major classes of antibiotic…
- Available Online
- View e-Book
- Other Authors
- Zaidi, Syed Tabish R
- Roberts, Jason A
- Responsibility
- Syed Tabish R. Zaidi, Jason A. Roberts, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiii, 133 p. : 2 illus.)
- ISBN
- 9783319440347
- 9783319440323 (print ed.)
- Subjects (MeSH)
- Drug Dosage Calculations
- Obesity - complications
- Pharmaceutical Preparations - administration & dosage
- Pharmacokinetics
- Abstract
- This book provides an up to date review on antimicrobials dosing in obese patients, including practice recommendations for clinical use. The book is written by a group of doctors and pharmacists working in infectious diseases practice and research. The introductory chapter outlines the important physiological changes in obesity including factors affecting the dosing of antimicrobials in obese patients. The introductory chapter is followed by ten chapters covering the major classes of antibiotics, antifungals, and antivirals. Each chapter briefly discuss the pharmacokinetics changes related to obesity and a summary of the relevant up-to-date literature. Specific dosing recommendations are provided for each class supplemented by real-life examples as clinical cases that are included as an appendix to the book. The book is a useful resource for clinicians, students and researchers needing up-to-date information on antimicrobial dosing in obese patients. Doctors, pharmacists, nurses working in hospital settings, and students of health courses (medical, pharmacy and nursing students) will find this book particularly useful.
- Contents
- 1. Introduction -- 2. Penicillins -- 3. Cephalosporins -- 4. Aminoglycoside Dosing in Obesity -- 5. Fluoroquinolones -- 6. Carbapenems -- 7. Glycopeptides and Antibiotics for Gram-positive Bacterial Infections -- 8. Azole Antifungal Agents -- 9. Echinocandin Antifungals -- 10. Polyene Antifungals -- 11. Miscellaneous Agents -- Appendix 1. Clinical Cases.
- Format
- e-Book
- Location
- Online
Clinical Cardiogenetics
https://libcat.nshealth.ca/en/permalink/provcat40329
Hubert F. Baars, Pieter A. F. M. Doevendans, Arjan C. Houweling, J. Peter van Tintelen, editors.
(2nd ed.)
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This extensively revised second edition provides a thorough basic knowledge on the genetic aspects of cardiovascular disorders. Many cardiologists have not been specifically trained in genetics, let alone in explaining genetics to their patients. While clinics for cardiogenetic disorders have been established in many academic teaching hospitals, it is neither desirable nor feasible that the care for this large group of patients and their relatives remains solely restricted to this small number …
- Available Online
- View e-Book
- Responsibility
- Hubert F. Baars, Pieter A. F. M. Doevendans, Arjan C. Houweling, J. Peter van Tintelen, editors
- Edition
- 2nd ed.
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (viii, 405 p. : 93 illus., 55 illus. in color)
- ISBN
- 9783319442037
- 9783319442020 (print ed.)
- Subjects (MeSH)
- Cardiovascular Diseases - genetics
- Genetic predisposition to disease
- Abstract
- This extensively revised second edition provides a thorough basic knowledge on the genetic aspects of cardiovascular disorders. Many cardiologists have not been specifically trained in genetics, let alone in explaining genetics to their patients. While clinics for cardiogenetic disorders have been established in many academic teaching hospitals, it is neither desirable nor feasible that the care for this large group of patients and their relatives remains solely restricted to this small number of centers. This book reviews the expertise that all cardiologists, clinical and molecular geneticists, genetic nurses, and social workers need to provide optimal care for individuals with cardiac disease of probable genetic origin and their family members. Clinical Cardiogenetics, Second Edition, compiles the huge amount of information available in a single easy-to-read textbook. It does not require prior expert genetic knowledge and provides a practical clinical primer for cardiologists and other physicians involved in the management of these patients. With the continuing increase in genetic knowledge, and the expanding possibilities to prevent fatal arrhythmias in those individuals at high risk, a steady increase in questions regarding genetics from patients and their relatives in the years to come should be expected. This comprehensive textbook is a valuable tool in dealing with such questions.
- Contents
- Part I: Genetics -- 1 Introduction to Molecular Genetics -- 2 Clinical Genetics -- Part II: Cardiomyopathies -- 3 Introduction Hereditary Cardiomyopathies -- 4 Hypertrophic Cardiomyopathy -- 5 Dilated Cardiomyopathy -- 6 Arrhythmogenic Cardiomyopathy -- 7 Left Ventricular Noncompaction -- 8 Restrictive Cardiomyopathy -- 9 Mitochondrial Cardiomyopathy -- Part III: Hereditary Arrhythmia Syndromes -- 10 Long QT Syndrome -- 11 Brugada Syndrome -- 12 Catecholaminergic Polymorphic Ventricular Tachycardia -- 13 Short QT Syndrome -- 14 Idiopathic Ventricular Fibrillation -- 15 A Molecular Genetic Perspective on Atrial Fibrillation -- 16 Hereditary Cardiac Conduction Diseases -- Part IV: Hereditary Aortic Diseases -- 17 Heritable Thoracic Aortic Disorders -- 18 Bicuspid Aortic Valve -- Part V: Sudden Cardiac Death in the Young -- 19 Sudden Cardiac Death in the Young; Epidemiology and Cardiogenetic Evaluation of Victims and Their Relatives -- Part VI: Miscellaneous -- 20 The Genetics of Mitral Valve Prolapse -- 21 Genetic Disorders of Lipoprotein Metabolism: Diagnosis and Management -- 22 Genetics of (Premature) Coronary Artery Disease -- 23 Hereditary Neuromuscular Diseases and Cardiac Involvement -- 24 Future of Cardiogenetics -- Index.
- Format
- e-Book
- Location
- Online
