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Damage-Associated Molecular Patterns in Human Diseases : Volume 1. Injury-Induced Innate Immune Responses

https://libcat.nshealth.ca/en/permalink/provcat42536
Walter Gottlieb Land. --Cham: Springer , c2018.
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This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress response…
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Author
Land, Walter Gottlieb
Responsibility
Walter Gottlieb Land
Alternate Title
Injury-induced innate immune responses
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xlviii, 870 p.) : 115 illus., 102 illus. in color
ISBN
9783319786551
9783319786544 (print ed.)
9783319786568 (print ed.)
Subjects (MeSH)
Biomarkers - analysis
Immunologic Techniques
Molecular Medicine
Pathogen-Associated Molecular Pattern Molecules
Stress, Physiological - immunology
Wounds and Injuries - immunology
Specialty
Diagnosis
Molecular Medicine
Pathology
Abstract
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
Contents
Part I. The Three Major Paradigms in Modern Immunology -- Prologue: The Term "Immunity" over the Course of Time -- The Three Major Paradigms in Immunology -- Epilogue: What Major Paradigm in Immunology Comes Next? -- Part II. The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis -- Prologue: The Guardians of Homeostasis -- Innate Immune Recognition Molecules -- Epilogue: The Innate Immune System: a Global Player in Health and Disease -- Part III. The Whole Family of Mammalian Innate Immune Cells -- Prologue: The Whole Body as an Immune System? -- Mobile Innate Immune Cells -- Sessile Innate Immune Cells -- Epilogue: The Whole Body as an Immune Defence System -- Part IV. The World of DAMPs. Prologue: About DAMPs, PAMPs and MAMPs -- Endogenous DAMPs, Category I: Constitutively Expressed Native Molecules (Cat. I DAMPs) -- Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs) -- Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs) -- Exogenous DAMPs, Category IV (Cat. IV DAMPs) -- Epilogue: The Well-Dosed Work of DAMPs in their Commission to Restore and Maintain Homeostasis -- Part V. Cellular Stress Responses and Regulated Cell Death -- Prologue: Innate Immune Tools to Defend against Stressful Injury: Success and Failure -- Cell-Autonomous (Cell-Intrinsic) Stress Responses -- Regulated Cell Death -- Epilogue: The Horror of an Injury-Induced Avalanche of DAMPs -- Part VI. Innate Immune Effector Responses -- Prologue: The Various Facets of Innate Immune Effector Responses -- Cellular Inflammatory Responses -- Humoral Innate Immune Effector Responses -- Regulation of Innate Inflammatory Responses -- Epilogue to Part VI -- Part VII. Function of Innate Lymphoid Cells and Unconventional T Cells with Partial Innate Function -- Prologue: The "Ready-to-Go" Lymphocytes of the Immune System -- Activating and Function of Innate Lymphoid Cells -- Activating and Function of Unconventional T Cells -- Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches -- Part VIII. DAMPs Promoting Adaptive Immunity and Tissue Repair -- Prologue: The "Long Arm" of DAMPs in Shaping Adaptive Immune Responses and Tissue Repairing Processes -- Antigen Uptake, Processing and Presentation by Dendritic Cells -- Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote "Destructive" Acquired Immune Responses -- Antigen in the Absence of DAMPs Promotes Immunotolerance: the Role of Dendritic Cells and Regulatory T Cells -- An Impressive Example of Peripheral Tolerance against Nonself: Tolerance to Commensal Bacterial and Dietary Protein Antigens -- Immunometabolism of Dendritic Cells and T Cells -- Role of DAMPs in Tissue Regeneration and Repair -- Epilogue: DAMPs as Key Players in the Pathogenesis of Many Human Diseases.
Format
e-Book
Location
Online
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Manual of Cardiovascular Proteomics

https://libcat.nshealth.ca/en/permalink/provcat40208
Giulio Agnetti, Merry L. Lindsey, D. Brian Foster, editors. --Cham: Springer , c2016.
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This book highlights the remarkable advances that have contributed to the development of proteomics over the last two decades. While many of the concepts, methods, and technologies can be widely applied across fields of biomedical research, this book has been tailored for the cardiovascular researcher, with the many facets of cardiovascular disease reflected within the chapters. New methods and technologies are discussed in a manner that is understandable to scientists who are new to the proteo…
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Other Authors
Agnetti, Giulio
Lindsey, Merry L
Foster, D. Brian
Responsibility
Giulio Agnetti, Merry L. Lindsey, D. Brian Foster, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xvi, 430 p. : 65 illus., 58 illus. in color)
ISBN
9783319318288
9783319318264 (print ed.)
Subjects (MeSH)
Biomarkers - analysis
Cardiovascular Diseases - metabolism
Cardiovascular System - metabolism
Proteomics - methods
Abstract
This book highlights the remarkable advances that have contributed to the development of proteomics over the last two decades. While many of the concepts, methods, and technologies can be widely applied across fields of biomedical research, this book has been tailored for the cardiovascular researcher, with the many facets of cardiovascular disease reflected within the chapters. New methods and technologies are discussed in a manner that is understandable to scientists who are new to the proteomics arena in order to accelerate knowledge dissemination. The full measure of topics that define modern cardiovascular proteomics have been covered, including but not limited to experimental design, sample preparation and separation, mass spectrometry technologies, protein identification and quantitation, as well as statistical, pathway and network analyses of proteomics results. Manual of Cardiac Proteomics addresses many of the technical subtleties to be considered when embarking on a cardiovascular proteomic study. It as an invaluable guide for scientists entering the field, as well as clinicians and trainees in cardiology and all related disciplines.
Contents
1. A Historical Perspective on Cardiovascular Proteomics -- 2. Basic Concepts in Mass Spectrometry and Protein Quantitation -- 3. How to Design a Cardiovascular Proteomics Experiment -- 4. Organelle, Protein and Peptide Fractionation in Cardiovascular Proteomics -- 5. Vascular Proteomics -- 6 Stem Cell Proteomics -- 7. Bottom-Up Proteomics -- 8. Top-Down Proteomics -- 9. Targeted Proteomics (MRM) in Cardiovascular Research -- 10. Label-Free Quantification by Data Independent Acquisition Mass Spectrometry to Map Cardiovascular Proteomes -- 11. Labeling and Label-Free Shotgun Proteomics Quantification in the Research of Cardiovascular Diseases -- 12. Analysis of Proteomic Data -- 13. Post-translational Modifications in the Cardiovascular Proteome -- 14. Proteomic Network Systems Analysis -- 15. Sensing and Remembering Cellular States Through Chromatin -- 16. Synergizing Proteomic and Metabolomic Data to Study Cardiovascular Systems -- 17. Clinical Cardiovascular Proteomics -- 18. Concluding Remarks: Proteomics AD 2025.
Format
e-Book
Location
Online
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Molecular Allergy Diagnostics : Innovation for a Better Patient Management

https://libcat.nshealth.ca/en/permalink/provcat41424
Jörg Kleine-Tebbe, Thilo Jakob, editors. --Cham: Springer , 2017.
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This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims t…
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Other Authors
Kleine-Tebbe, Jörg
Jakob, Thilo
Responsibility
Jörg Kleine-Tebbe, Thilo Jakob, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xx, 531 pages) : 112 illus., 100 illus. in color
ISBN
9783319424996
9783319424989 (print ed.)
Subjects (MeSH)
Allergens - immunology
Biomarkers - analysis
Hypersensitivity - diagnosis
Immunoglobulin E - immunology
Molecular Diagnostic Techniques
Sensitivity and Specificity
Abstract
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a "must read" for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.
Contents
Part I: Protein Families and Relationships -- 1. Introduction to Molecular Allergology: Protein Families, Databases, and Potential Benefits -- 2. Bet v 1 and its Homologs: Triggers of Tree-Pollen Allergy and Birch Pollen-Associated Cross-Reactions -- 3. The Concept of Pollen Panallergens: Profilins and Polcalcins -- 4. Stable Plant Food Allergens I: Lipid-Transfer Proteins -- 5. Stable Plant Food Allergens II: Storage Proteins -- 6. Cross-Reactive Carbohydrate Determinants: Diagnostic and Clinical Relevance -- Part II: Test Systems, Singleplex Analysis and Multiplex Analysis -- 7. Molecular Allergy Diagnostics Using IgE Singleplex Assays: Methodological and Practical Considerations -- 8. Spiking with Recombinant Individual Allergens for Improvement of Allergen Extracts -- 9. Molecular Allergy Diagnostics Using Multiplex Assays -- Part III: Marker Allergens -- 10. Marker Allergens and Panallergens in Tree and Grass Pollen Allergy -- 11. Marker Allergens of Weed Pollen: Basic Considerations and Diagnostic Benefits in Routine Clinical Practice -- 12. Molecular Diagnostics for Peanut Allergy -- 13. Molecular Diagnostics for Tree Nut Allergy -- 14. Molecular Diagnostics of Allergy to Fruits and Vegetables -- 15. Cow’s Milk and Hen’s Egg Allergy: What Do Molecular-Based Allergy Diagnostics Have to Offer? -- 16. Molecular and Extract-Based Diagnostics in Meat Allergy -- 17. Molecular Diagnostics in Food-Dependent Exercise-Induced Anaphylaxis -- 18. Benefits and Limitations of Recombinant Allergens in Diagnostics of Insect Venom Allergy -- 19. Molecular Diagnostics in Allergy to Mammals -- 20. Extract-Based and Molecular Diagnostics in Fish Allergy -- 21. Allergens and Molecular Diagnostics of Shellfish Allergy -- 22. Allergens, Diagnostics, and Therapeutic Aspects in House Dust Mite Allergy -- 23. Cockroach, Tick, Storage Mite, and Other Arthropod Allergies: Molecular Aspects -- 24. Mold Allergens and Their Importance in Molecular Allergy Diagnosis -- 25. Latex Allergens: Source of Sensitization and Single Allergens -- Part IV: Designer Allergens, Hypoallergens and Fusion Allergens -- 26. Recombinant Allergens in Specific Immunotherapy -- 27. Definition and Design of Hypoallergenic Foods.
Format
e-Book
Location
Online
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