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Application of peptide-based prodrug chemistry in drug development

https://libcat.nshealth.ca/en/permalink/provcat32406
Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez. --New York, NY: Springer , c2013.
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Online
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Author
De, Arnab
Responsibility
Arnab De, author ; with special thanks to Richard DiMarchi and the Linda & Jack Gill Chair in Biomolecular Sciences at Indiana University ; with foreword by Jean Martinez
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Series Title
SpringerBriefs in pharmaceutical science & drug development
ISBN
9781461448754
Subjects (MeSH)
Drug Design
Peptides - pharmacology
Prodrugs
Subjects (LCSH)
Toxicology
Pharmaceutical technology
Diabetes
Contents
Introduction -- Application of prodrug chemistry to GLP-1 -- Experimental procedures -- Characterization of prodrugs -- Conclusion -- Appendix I: Schematic Synthesis of Longer Acting Prodrugs -- Appendix II: Structure of Peptides in Table A.1 -- Appendix III: Structure of Peptides in Table A.2 -- Appendix IV: Structure of Peptides in Table A.3 -- Appendix V: Structure of Peptides in Table A.4 -- Appendix VI: Structure of Peptides in Table A.5 -- Appendix VII: Structure of Peptides in Table A.6 -- Appendix VIII: Acylation of HO-His7, GLP(8–37) -- Appendix IX: A Note on Nomenclature.
Format
e-Book
Location
Online
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Atlas of Diabetes

https://libcat.nshealth.ca/en/permalink/provcat30932
edited by Jay Skyler. (4th ed.) --New York, NY: Springer , c2012.
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Diabetes mellitus is increasing in incidence, prevalence, and importance as a chronic disease throughout the world. The International Diabetes Federation projects that by 2030 there will be 438 million people with diabetes on a global scale. In the United States, the Centers for Disease Control calculates that 25.8 million people (or 8.3% of the population) have diabetes and nearly 2 million Americans develop diabetes each year. Thus, the burden of diabetes is enormous in terms of the magnitude…
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Other Authors
Skyler, Jay
Responsibility
edited by Jay Skyler
Edition
4th ed.
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (x, 422 p. : 502 ill., 395 ill. in color)
ISBN
9781461410287
Subjects (MeSH)
Diabetes Mellitus - Atlases
Subjects (LCSH)
Diabetes
Abstract
Diabetes mellitus is increasing in incidence, prevalence, and importance as a chronic disease throughout the world. The International Diabetes Federation projects that by 2030 there will be 438 million people with diabetes on a global scale. In the United States, the Centers for Disease Control calculates that 25.8 million people (or 8.3% of the population) have diabetes and nearly 2 million Americans develop diabetes each year. Thus, the burden of diabetes is enormous in terms of the magnitude of the population affected. There has been an exciting explosion of knowledge about fundamental mechanisms related to diabetes. We have gained insights into the pathogenesis both of type 1 and type 2 diabetes, and with that, the prospect of implementing prevention strategies to delay or interdict the disease processes. Great progress has been made in islet transplantation, which offers the potential of reversing diabetes, while approaches to islet replacement by regeneration or stem cell therapy are in their infancy. Whether diabetes prevention will come from advances in understanding the processes of islet neogenesis and proliferation, from genetic engineering, or from protecting xenoislets or stem cells from immunologic attack remains unclear. All are potential avenues of pursuit. This newly revised, comprehensive, four-color Atlas of Diabetes, 4th Edition, is extensively updated with references to the current literature. Developed by leading authorities in the field, this Atlas offers an indispensable collection of images, including algorithms, tables, charts, and schematic drawings. It continues its role as a leading reference work and an invaluable contribution to the field.
Contents
Regulation of Insulin Secretion and Islet Cell Function -- Mechanisms of Insulin Action -- Consequences of Insulin Deficiency -- Type 1 Diabetes -- Management of Type 1 Diabetes -- Childhood Diabetes -- Pathogenesis of Type 2 Diabetes -- Management of Type 2 Diabetes Mellitus -- Diabetes and Pregnancy -- Mechanisms of Hyperglycemic Damage in Diabetes -- Management and Prevention of Diabetic Complications -- Eye Complications of Diabetes -- Diabetes and the Kidney -- Diabetic Neuropathies -- Obesity Therapy -- Reversal of Diabetes: Islet Cell Transplantation -- Technology and Diabetes: Insulin Delivery Systems and Glucose Sensing -- Newer Diabetes Medications.
Format
e-Book
Location
Online
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Central diabetes insipidus

https://libcat.nshealth.ca/en/permalink/chpams34833
Nova Scotia Health Authority. Endocrinology. Halifax, NS: Nova Scotia Health Authority , 2021.
Pamphlet Number
1096
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Central diabetes insipidus (diabetes insipidus or DI) is a rare disorder of water balance. DI can easily cause dehydration (not having enough fluids). This is a serious risk for people with DI and can be dangerous. If you have DI, drink a lot of fluids so that you do not become dehydrated. This pamphlet explains the causes and symptoms of DI, and how DI is diagnosed and treated. Information about the provincial funding program for DI medication is given.
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Corporate Author
Nova Scotia Health Authority. Endocrinology
Place of Publication
Halifax, NS
Publisher
Nova Scotia Health Authority
Date of Publication
2021
Format
Pamphlet
Language
English
Physical Description
1 electronic document (6 p.) : digital, PDF file
Subjects (MeSH)
Diabetes Insipidus
Subjects (LCSH)
Diabetes
Specialty
Endocrine System
Abstract
Central diabetes insipidus (diabetes insipidus or DI) is a rare disorder of water balance. DI can easily cause dehydration (not having enough fluids). This is a serious risk for people with DI and can be dangerous. If you have DI, drink a lot of fluids so that you do not become dehydrated. This pamphlet explains the causes and symptoms of DI, and how DI is diagnosed and treated. Information about the provincial funding program for DI medication is given.
Responsibility
Prepared by Endocrinology
Pamphlet Number
1096
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Controversies in Treating Diabetes : Clinical and Research Aspects

https://libcat.nshealth.ca/en/permalink/provcat30306
edited by Derek LeRoith, Aaron I. Vinik. --Totowa, NJ: Humana Press , c2008.
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Location
Online
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Author
LeRoith, Derek
Other Authors
Vinik, Aaron I
Responsibility
edited by Derek LeRoith, Aaron I. Vinik
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2008
Series Title
Contemporary endocrinology (Totowa, N.J.)
ISBN
9781597455725
Subjects (MeSH)
Diabetes Mellitus - therapy
Subjects (LCSH)
Diabetes
Format
e-Book
Location
Online
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Diabetes and Cardiovascular Disease

https://libcat.nshealth.ca/en/permalink/provcat30146
edited by Michael T. Johnstone, Aristidis Veves. (2nd ed.) --Totowa, NJ: Humana Press , c2005.
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Location
Online
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Author
Johnstone, Michael T
Other Authors
Veves, Aristidis
Responsibility
edited by Michael T. Johnstone, Aristidis Veves
Edition
2nd ed.
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2005
Series Title
Contemporary cardiology (Totowa, N.J. : Unnumbered)
ISBN
9781592599080
Subjects (MeSH)
Diabetic Cardiomyopathies
Cardiovascular Diseases - etiology
Diabetes Complications
Subjects (LCSH)
Diabetes
Cardiology
Format
e-Book
Location
Online
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Diabetes and Hypertension : Evaluation and Management

https://libcat.nshealth.ca/en/permalink/provcat30989
Samy I. McFarlane, George L. Bakris, editors. --New York, NY: Humana Press , c2012.
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Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary i…
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Other Authors
McFarlane, Samy I
Bakris, George L, 1952-
Responsibility
Samy I. McFarlane, George L. Bakris, editors
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xi, 190 p. : 35 ill., 18 ill. in color)
Series Title
Contemporary diabetes
ISBN
9781603273572
Subjects (MeSH)
Diabetes Complications - prevention & control
Diabetes Complications - therapy
Diabetes Mellitus - prevention & control
Hypertension - complications
Hypertension - therapy
Risk Factors
Subjects (LCSH)
Cardiology
Diabetes
Endocrinology 
Abstract
Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
Contents
Epidemiology of Hypertension in Diabetes -- Evaluation and Management of Secondary Hypertension -- Hypertension in African-Americans -- Hypertension in Chronic Kidney Disease -- Diabetes and Hypertension in People with Sleep Apnea: Risk Evaluation and Therapeutic Rationale -- Resistant Hypertension: Etiology, Evaluation and Management -- Diabetes and Cardiovascular Disease -- Hypertension, Diabetes and the Eye -- Predictors of Kidney Disease in Diabetic, Hypertensive Patients -- Antihypertensive Therapy and New Onset Diabetes -- Global Cardiovascular Risk Reduction in People with Diabetes Mellitus and Hypertension -- Prevention of Type 2 Diabetes: Evidence from Clinical Trials -- Dietary and Lifestyle Approaches to Hypertension in the Population with Diabetes -- Novel Pharmacological Approaches in Hypertension Treatment.
Format
e-Book
Location
Online
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Diabetes and the eye

https://libcat.nshealth.ca/en/permalink/chpams34520
Nova Scotia Health Authority. Eye Care Centre. Halifax, NS: Nova Scotia Health Authority , 2021.
Pamphlet Number
0459
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Diabetic retinopathy happens when changes take place in the blood vessels near the retina, causing leaks or bleeding. Diabetic macular edema is a swelling of the macula (very small centre area of your retina, which gives you the central vision needed to do things like reading, watching TV, and seeing faces) that may be caused by diabetes, happen after eye surgery, or happen for no known reason (idiopathic). The pamphlet describes these disorders, their treatment, and how to control them. The Fr…
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Corporate Author
Nova Scotia Health Authority. Eye Care Centre
Place of Publication
Halifax, NS
Publisher
Nova Scotia Health Authority
Date of Publication
2021
Format
Pamphlet
Language
English
Physical Description
1 electronic document (5 p.) : digital, PDF file
Subjects (MeSH)
Diabetes Complications
Diabetic Retinopathy
Subjects (LCSH)
Diabetes--Complications
Diabetic retinopathy
Specialty
Diabetes
Ophthalmology
Abstract
Diabetic retinopathy happens when changes take place in the blood vessels near the retina, causing leaks or bleeding. Diabetic macular edema is a swelling of the macula (very small centre area of your retina, which gives you the central vision needed to do things like reading, watching TV, and seeing faces) that may be caused by diabetes, happen after eye surgery, or happen for no known reason (idiopathic). The pamphlet describes these disorders, their treatment, and how to control them. The French version of this pamphlet 1784, "Le diabète et les yeux", is also available.
Responsibility
Prepared by: Eye Care Centre
Pamphlet Number
0459
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Diabetes Care for the Older Patient : A Practical Handbook

https://libcat.nshealth.ca/en/permalink/provcat30812
Gillian Hawthorne (editor). --London: Springer , c2012.
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The management of older people with diabetes requires careful attention to the specific needs of this age group. This practical handbook addresses the issues surrounding the care of older diabetic patients, including dementia, frailty, depression and cardiovascular risk. Intended for day-to-day use in clinical practice, each chapter closes with a list of salient practical points in the clinical management of older patients with diabetes. Concisely written by authorities in the field, this book…
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Other Authors
Hawthorne, Gillian
Responsibility
Gillian Hawthorne (editor)
Place of Publication
London
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (viii, 175 p. : 11 ill., 6 ill. in color)
ISBN
9780857294616
Subjects (MeSH)
Diabetes Mellitus - therapy
Subjects (LCSH)
Geriatrics
Diabetes
Endocrinology 
Emergency medicine
Abstract
The management of older people with diabetes requires careful attention to the specific needs of this age group. This practical handbook addresses the issues surrounding the care of older diabetic patients, including dementia, frailty, depression and cardiovascular risk. Intended for day-to-day use in clinical practice, each chapter closes with a list of salient practical points in the clinical management of older patients with diabetes. Concisely written by authorities in the field, this book is a valuable resource for all those involved in the diabetes care of older people.
Contents
The Epidemiology of Diabetes in Older People -- Type 2 Diabetes and Dementia -- Depression in Older People with Diabetes -- Hypoglycaemia and the Older Person -- Cardiovascular Risk, Glucose and Targets for Management of Diabetes in Older People -- Diabetes and Frailty -- Perceptions of Users and Carers in Supporting Diabetes Care: Practical Guidance, Support and Information for Carers -- Management of Elderly People with Diabetes in Primary Care.
Format
e-Book
Location
Online
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Diabetes Centre : Digby General Hospital, Roseway Hospital, Yarmouth Regional Hospital

https://libcat.nshealth.ca/en/permalink/chpams36549
Nova Scotia Health Authority. Diabetes Centre. Digby General Hospital, Nova Scotia Health Authority. Diabetes Centre. Roseway Hospital, Nova Scotia Health Authority. Diabetes Centre. Yarmouth Regional Hospital. Halifax, NS: Nova Scotia Health Authority , 2019.
Pamphlet Number
1982
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If you or a loved one has been diagnosed with diabetes (type 1 or 2) or gestational diabetes and you have questions or concerns about your diabetes, high or low blood sugar, diabetes medication, or other medications, then you may find it helpful to visit a Diabetes Centre. This pamphlet answers common questions about the Diabetes Centres in the following locations: Digby Hospital (Meteghan satellite), Yarmouth Regional Hospital, and Roseway Hospital (Barrington Passage satellite).
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Corporate Author
Nova Scotia Health Authority. Diabetes Centre. Digby General Hospital
Nova Scotia Health Authority. Diabetes Centre. Roseway Hospital
Nova Scotia Health Authority. Diabetes Centre. Yarmouth Regional Hospital
Place of Publication
Halifax, NS
Publisher
Nova Scotia Health Authority
Date of Publication
2019
Format
Pamphlet
Language
English
Physical Description
1 electronic document ([4] p.) : digital, PDF file
Subjects (MeSH)
Diabetes Insipidus
Subjects (LCSH)
Diabetes
Abstract
If you or a loved one has been diagnosed with diabetes (type 1 or 2) or gestational diabetes and you have questions or concerns about your diabetes, high or low blood sugar, diabetes medication, or other medications, then you may find it helpful to visit a Diabetes Centre. This pamphlet answers common questions about the Diabetes Centres in the following locations: Digby Hospital (Meteghan satellite), Yarmouth Regional Hospital, and Roseway Hospital (Barrington Passage satellite).
Responsibility
Prepared by: Diabetes Centre, Digby, Roseway, & Yarmouth
Pamphlet Number
1982
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Diabetes & C-Peptide : Scientific and Clinical Aspects

https://libcat.nshealth.ca/en/permalink/provcat31009
Anders A.F. Sima, editor. --New York, NY: Humana Press , c2012.
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Location
Online
In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, includ…
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Other Authors
Sima, Anders A.F
Responsibility
Anders A.F. Sima, editor
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (xiii, 169 p. : 63 ill., 35 ill. in color)
Series Title
Contemporary diabetes
ISBN
9781617793912
Subjects (MeSH)
C-Peptide - physiology
C-Peptide - therapeutic use
Diabetes Complications - prevention & control
Diabetes Mellitus, Type 1 - drug therapy
Subjects (LCSH)
Diabetes
Endocrinology 
Biochemistry
Abstract
In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.
Contents
C-peptide and Insulin: A Happy Marriage -- Peptide Interactions of Proinsulin C-peptide -- The Effect of Combined C-peptide and Zinc on Cellular Function -- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy -- Role of C-Peptide in the Regulation of Microvascular Blood Flow -- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy? -- Renoprotective Effects of C-Peptide in Type I Diabetes -- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy -- C-peptide and Type 1 Diabetic Encephalopathy -- C-peptide: a New Molecule with Anti-Inflammatory Properties -- C-peptide: Connecting Diabetes with Macrovascular Complications -- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes -- Proatherogenic Effects of C-Peptide -- Conclusions and Future Outlook.
Format
e-Book
Location
Online
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Diabetes in Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat29711
by Vivian Fonseca, Merri Pendergrass, Roberta Harrison McDuffie. --London: Springer-Verlag , c2010.
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Location
Online
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Author
Fonseca, Vivian
Other Authors
Pendergrass, Merri
Harrison McDuffie, Roberta
Responsibility
by Vivian Fonseca, Merri Pendergrass, Roberta Harrison McDuffie
Place of Publication
London
Publisher
Springer-Verlag
Date of Publication
c2010
ISBN
9781848821033
Subjects (MeSH)
Diabetes Mellitus
Subjects (LCSH)
Diabetes
Format
e-Book
Location
Online
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The Diabetic Kidney

https://libcat.nshealth.ca/en/permalink/provcat29840
edited by Pedro Cortes, Carl Erik Mogensen. --Totowa, NJ: Humana Press , c2006.
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Location
Online
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Author
Cortes, Pedro
Other Authors
Mogensen, Carl Erik
Responsibility
edited by Pedro Cortes, Carl Erik Mogensen
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2006
Series Title
Contemporary diabetes
ISBN
9781597451536
Subjects (MeSH)
Diabetic Nephropathies
Kidney Diseases - etiology
Diabetes Complications
Subjects (LCSH)
Diabetes
Nephrology
Format
e-Book
Location
Online
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Diabetic Neuropathy : Clinical Management

https://libcat.nshealth.ca/en/permalink/provcat29035
edited by Aristidis Veves, Rayaz A. Malik. (2nd ed.) --Totowa, NJ: Humana Press , c2007.
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Location
Online
Available Online
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Author
Veves, Aristidis
Other Authors
Malik, Rayaz A
Responsibility
edited by Aristidis Veves, Rayaz A. Malik
Edition
2nd ed.
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2007
Series Title
Clinical Diabetes
ISBN
9781597453110
Subjects (MeSH)
Diabetic Neuropathies - therapy
Diabetes Complications
Subjects (LCSH)
Diabetes
Neurology
Format
e-Book
Location
Online
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Diabetic Retinopathy

https://libcat.nshealth.ca/en/permalink/provcat29872
edited by Elia J. Duh. --Totowa, NJ: Humana Press , c2008.
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Location
Online
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Author
Duh, Elia J
Responsibility
edited by Elia J. Duh
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2008
Series Title
Contemporary diabetes
ISBN
9781597455633
Subjects (MeSH)
Diabetic Retinopathy
Diabetes Complications
Subjects (LCSH)
Diabetes
Ophthalmology
Format
e-Book
Location
Online
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Diabetic Retinopathy : Evidence-Based Management

https://libcat.nshealth.ca/en/permalink/provcat28390
edited by David J. Browning. --New York, NY: Springer-Verlag , c2010.
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Location
Online
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Author
Browning, David J
Responsibility
edited by David J. Browning
Place of Publication
New York, NY
Publisher
Springer-Verlag
Date of Publication
c2010
ISBN
9780387859002
Subjects (MeSH)
Diabetic Retinopathy - therapy
Diabetes Complications
Subjects (LCSH)
Diabetes
Ophthalmology
Format
e-Book
Location
Online
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Le diabète et les yeux

https://libcat.nshealth.ca/en/permalink/chpams35838
Nova Scotia Health Authority. Eye Care Centre. Halifax, NS: Nova Scotia Health Authority , 2017.
Pamphlet Number
1784
Available Online
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La rétinopathie diabétique est causée par des changements au niveau des vaisseaux sanguins de la rétine qui entraînent une fuite ou un saignement. L’œdème maculaire diabétique est un gonflement de la zone maculaire qui peut être causé par le diabète, se produire après une chirurgie de l’œil ou pour une raison inconnue. Le présent dépliant décrit ces troubles, leur traitement et la façon de les gérer. ; This pamphlet is a French translation of "Diabetes and the Eye" pamphlet 0459. Diabetic retin…
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Corporate Author
Nova Scotia Health Authority. Eye Care Centre
Alternate Title
Diabetes and the eye
Place of Publication
Halifax, NS
Publisher
Nova Scotia Health Authority
Date of Publication
2017
Format
Pamphlet
Language
French
Physical Description
1 electronic document (6 p.) : digital, PDF file
Subjects (MeSH)
Diabetes Complications
Diabetic Retinopathy
Subjects (LCSH)
Diabetes--Complications
Diabetic retinopathy
Specialty
Diabetes
Ophthalmology
Abstract
La rétinopathie diabétique est causée par des changements au niveau des vaisseaux sanguins de la rétine qui entraînent une fuite ou un saignement. L’œdème maculaire diabétique est un gonflement de la zone maculaire qui peut être causé par le diabète, se produire après une chirurgie de l’œil ou pour une raison inconnue. Le présent dépliant décrit ces troubles, leur traitement et la façon de les gérer.
This pamphlet is a French translation of "Diabetes and the Eye" pamphlet 0459. Diabetic retinopathy is caused by changes in the blood vessels of the retina that result in leakage or bleeding. Diabetic macular edema is a swelling of the macular area that may be caused by diabetes, happen after eye surgery or happen for no known reason. The pamphlet describes these disorders, their treatment and how to control them.
Responsibility
Prepared by: Eye Care Centre
Pamphlet Number
1784
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Drug delivery systems : advanced technologies potentially applicable in personalised treatment

https://libcat.nshealth.ca/en/permalink/provcat32644
Jorge Coelho, editor. --Dordrecht: Springer , c2013.
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Location
Online
This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (APPPM). It focuses on the theme of 'Drug delivery systems: advanced technologies potentially applicable in personalised treatments'. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solut…
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Other Authors
Coelho, Jorge
Responsibility
Jorge Coelho, editor
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xvii, 421 p. : 124 ill., 67 ill. in color)
Series Title
Advances in predictive, preventive and personalised medicine
ISBN
9789400760103
Subjects (MeSH)
Drug Delivery Systems - methods
Individualized Medicine - methods
Pharmacogenetics
Subjects (LCSH)
Medicine
Polymers
Biochemistry
Diabetes
Abstract
This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (APPPM). It focuses on the theme of 'Drug delivery systems: advanced technologies potentially applicable in personalised treatments'. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.
Contents
Polymers in Drug Delivery: Concepts, Developments and Potential -- Amphiphilic Molecules in Drug Delivery Systems -- Sizing nanoparticles in liquids: an overview of methods -- Nanoparticles for oral delivery of insulin -- Bioartificial pancreas: in the road to clinical application -- Cationic liposome-based systems for nucleic acid delivery: from the formulation development to therapeutic applications -- Biomaterial-based vectors for targeted delivery of nucleic acids to the nervous system -- Three-dimensional (3D) scaffolds as drug delivery devices for Tissue engineering applications -- The Warburg Effect is a Guide to Multipurpose Cancer Therapy Including Trace Element Delivery -- In silico research in drug delivery systems -- The Importance of Controlled/Living Radical Polymerization Techniques in the Design of Tailor Made Nanoparticles for DSS -- Index.
Format
e-Book
Location
Online
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Gestational Diabetes During and After Pregnancy

https://libcat.nshealth.ca/en/permalink/provcat28787
edited by Catherine Kim, Assiamira Ferrara. --London: Springer-Verlag , c2010.
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Location
Online
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Author
Kim, Catherine
Other Authors
Ferrara, Assiamira
Responsibility
edited by Catherine Kim, Assiamira Ferrara
Place of Publication
London
Publisher
Springer-Verlag
Date of Publication
c2010
ISBN
9781848821200
Subjects (MeSH)
Diabetes, Gestational
Pregnancy Complications
Subjects (LCSH)
Obstetrics
Diabetes
Format
e-Book
Location
Online
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The globesity challenge to general surgery : a guide to strategy and techniques

https://libcat.nshealth.ca/en/permalink/provcat33438
Mirto Foletto, Raul J. Rosenthal, editors ; foreword by Nicola Scopinaro. --Milan: Springer , c2014.
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Location
Online
The increasing prevalence of morbid obesity has led the World Health Organization to coin the descriptive term "globesity" to reflect the worldwide nature of the problem. Providing health care to these patients, especially when surgery is required, can be extremely challenging owing to the specific needs in respect of logistics, facilities, and professional expertise. Appropriate care has too often been unachievable and unaffordable outside of established bariatric centers, but such centers the…
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Other Authors
Foletto, Mirto
Rosenthal, Raul J
Responsibility
Mirto Foletto, Raul J. Rosenthal, editors ; foreword by Nicola Scopinaro
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xiii, 246 pages)
ISBN
9788847053823 (electronic bk.)
9788847053816
Subjects (MeSH)
Bariatric Surgery - methods
Intraoperative Complications - prevention & control
Obesity - complications
Postoperative Complications - prevention & control
Surgical Procedures, Operative - methods
Subjects (LCSH)
Surgery
Overweight persons - Surgery
General Surgery
Minimally Invasive Surgery
Primary Care Medicine
Diabetes
Abstract
The increasing prevalence of morbid obesity has led the World Health Organization to coin the descriptive term "globesity" to reflect the worldwide nature of the problem. Providing health care to these patients, especially when surgery is required, can be extremely challenging owing to the specific needs in respect of logistics, facilities, and professional expertise. Appropriate care has too often been unachievable and unaffordable outside of established bariatric centers, but such centers themselves usually have insufficient capacity and resources to cope with growing demand. This book aims to provide guidance and helpful tips and tricks on how to deal with obese patients within a general surgery setting. Epidemiology, organizational and logistical aspects, nursing issues, patient assessment, anesthesiology, and surgical practicalities are expertly covered in the opening chapters. Techniques of relevance to the general surgeon are described according to anatomic region, covering the head and neck; cardiothoracic and vascular system; upper and lower GI tract; pancreas, liver and adrenal glands; urinary tract and kidneys; the reproductive system; and the abdominal wall. Results achieved by bariatric surgery worldwide are reviewed, and the book closes with a chapter devoted to plastic and reconstructive surgery. The Globesity Challenge to General Surgery highlights a need for global rethinking on public health as regards resource allocation and patterns and standards of care, improving outcomes through greater affordability.
Contents
1. Definition, Epidemiology and Social Implications of Obesity -- 2. Organizational Issues, Logistic and Economic Implications of Obesity -- 3. Nursing and Psychological Issues in Obese Patients -- 4. Patient Assessment and Post-Op Management of Obesity from the Physician?s Point of View -- 5. Anesthesiology in Obesity: Pre-Op Assessment, OR Strategy, Tips and Tricks for a Successful "Go-Through -- 6. Surgical Practicalities: Fast-Track Lessons from the Bariatric Surgery -- 7. Head and Neck Surgery in Obese patients -- 8. The Impact of Obesity in Thoracic and Cardiac Surgery -- 9. Upper GI Tract in Obese Patients -- 10. Lower GI Tract In Obesity -- 11. Pancreas, Liver and Adrenal Glands in Obesity -- 12. Effects of Bariatric Surgery on the Kidneys and Urinary Tract -- 13. OBGYN and Bariatric Surgery -- 14. Considerations on the Abdominal Wall in Obese Patients -- 15. Plastic and Reconstructive Surgery in Obese Patients -- 16. Bariatric Surgery Worldwide: Overview and Results.
Format
e-Book
Location
Online
Less detail

Glycemic Control in the Hospitalized Patient : A Comprehensive Clinical Guide

https://libcat.nshealth.ca/en/permalink/provcat28981
edited by Lillian F. Lien, Mary E. Cox, Mark N. Feinglos, Leonor Corsino. --New York, NY: Springer Science+Business Media , c2011.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Lien, Lillian F
Other Authors
Cox, Mary E
Feinglos, Mark N
Corsino, Leonor
Responsibility
edited by Lillian F. Lien, Mary E. Cox, Mark N. Feinglos, Leonor Corsino
Place of Publication
New York, NY
Publisher
Springer Science+Business Media
Date of Publication
c2011
ISBN
9781607610069
Subjects (MeSH)
Diabetes Mellitus
Hyperglycemia - therapy
Insulin - therapeutic use
Subjects (LCSH)
Endocrinology 
Diabetes
Format
e-Book
Location
Online
Less detail

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