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Adjuvant therapy for breast cancer

https://libcat.nshealth.ca/en/permalink/provcat30193
--Boston, MA: Springer-Verlag US , c2009.
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Online
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Castiglione, Monica
Piccart, Martine J
Place of Publication
Boston, MA
Publisher
Springer-Verlag US
Date of Publication
c2009
Series Vol.
151
Series Title
Cancer treatment and research
ISBN
9780387751153
Subjects (MeSH)
Adjuvants, Pharmaceutic
Breast Neoplasms - therapy
Chemotherapy, Adjuvant
Radiotherapy, Adjuvant
Subjects (LCSH)
Oncology
Gynecology
Format
e-Book
Location
Online
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Adult Vaccinations : Changing the Immunization Paradigm

https://libcat.nshealth.ca/en/permalink/provcat44121
Jean-Pierre Michel, Stefania Maggi, editors. --Cham: Springer , 2019.
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After introductory chapters devoted to the safe production and distribution of vaccines, the book addresses the question of adult vaccination in the framework of a life-course approach to vaccination. It presents the proceedings of multidisciplinary expert discussions with an excellent summary of the current state of knowledge on adult vaccination in various diseases, as well as an overview of the professionals involved and the obstacles to achieving greater vaccine uptake, and how these may be…
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Other Authors
Michel, Jean-Pierre
Maggi, Stefania
Responsibility
Jean-Pierre Michel, Stefania Maggi, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 127 p.) : 1 illus. in color
Series
Practical Issues in Geriatrics
Series Title
Practical issues in geriatrics
ISBN
9783030051594
9783030051587 (Print ed.)
9783030051600 (Print ed.)
ISSN
2509-6060
Subjects (MeSH)
Adult
Aging - immunology
Immunization
Vaccination
Vaccines
Specialty
Public Health
Abstract
After introductory chapters devoted to the safe production and distribution of vaccines, the book addresses the question of adult vaccination in the framework of a life-course approach to vaccination. It presents the proceedings of multidisciplinary expert discussions with an excellent summary of the current state of knowledge on adult vaccination in various diseases, as well as an overview of the professionals involved and the obstacles to achieving greater vaccine uptake, and how these may be addressed. The book systematically discusses the major vaccine-preventable diseases, as well as regulatory issues in vaccine provision, and presents the results of an expert meeting designed to identify the obstacles to vaccination, and solutions for addressing these barriers. It goes on to extend the discussion beyond the traditional boundaries of human health to encompass the “one health” concept. The book is intended for all those with an interest in vaccination, including physicians (from a wide range of disciplines including geriatrics/gerontology, infectious diseases, pediatrics, internal medicine, and other non-organ specialties), other healthcare professionals, pharmacists, representatives of the pharmaceutical industry and regulatory bodies (EMEA, national authorities), policymakers, the media and the general public.
Contents
Foreword. Adult vaccinations: essential but too often forgotten -- 1. Complexity of vaccine manufacture and supply -- 2. Administration of vaccines: current process, new technologies, adjuvants -- 3. How can the European Medicines Agency support an appropriate strategy of adult vaccination? -- 4. Public health impact of adult vaccine-preventable diseases on performance, disability, mortality and health care costs in Europe -- 5. Outcomes after HPV vaccination -- 6. Impact of nutrition on adult vaccination efficacy -- 7. Profiling vaccines for an immunosenescent and multimorbid population -- 8. Comprehensive geriatric assessment in infectious diseases -- 9. Etiology of respiratory tract infections in adults in Europe: current knowledge and knowledge gaps -- 10. European flu vaccine regulations and their impacts in community-dwelling adults -- 11. Vaccination against pneumococcal disease in the European Union, with particular focus on Germany -- 12. Direct and indirect benefits of a comprehensive approach to vaccinating adults with influenza and pneumococcal vaccines, especially in patients with chronic diseases -- 13. Vaccination of health care professionals and protection of hospitalized adults and nursing home residents -- 14. Ongoing threats for older Europeans: Diphtheria, Pertussis and Tetanus -- 15. Herpes Zoster vaccination: a vaccine to prevent pain -- 16. Gastroenteritis burden in the adult community: prospects for vaccines -- 17. Travel vaccination -- 18. Integrating the veterinarian scientist to the one-health concept -- 19. Stressing the importance of adult immunization: suggestions for how to change the paradigm -- 20. How can we integrate life course vaccination into the new WHO definition of “Healthy Ageing”?.
Format
e-Book
Location
Online
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Anesthesia of the upper limb : a state of the art guide

https://libcat.nshealth.ca/en/permalink/provcat33763
Fernando Alemanno, Mario Bosco, Aldo Barbati, editors. --Milan: Springer , c2014.
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Loco-regional anesthesia presents definite advantages in almost all surgical branches, since it couples a perfect anesthesia with a long postoperative analgesia. This discipline is constantly developing thanks to new drugs and new techniques. In the last decade the advent of ultrasound guided regional anesthesia has extended the study from the anatomic room to the virtual but real "in corpore viri" ecographic image thus increasing the success rate of this type of anesthesia. Together with elect…
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Alemanno, Fernando
Bosco, Mario
Barbati, Aldo
Responsibility
Fernando Alemanno, Mario Bosco, Aldo Barbati, editors
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xx, 291 pages)
ISBN
9788847054189 (electronic bk.)
9788847054172
Subjects (MeSH)
Anesthesia, Conduction - methods
Upper Extremity
Subjects (LCSH)
Conduction anesthesia
Anesthesiology
Anesthesia, Conduction
Upper Extremity - surgery
Abstract
Loco-regional anesthesia presents definite advantages in almost all surgical branches, since it couples a perfect anesthesia with a long postoperative analgesia. This discipline is constantly developing thanks to new drugs and new techniques. In the last decade the advent of ultrasound guided regional anesthesia has extended the study from the anatomic room to the virtual but real "in corpore viri" ecographic image thus increasing the success rate of this type of anesthesia. Together with electrostimulation, it has definitely increased the success rate of loco-regional anesthesia. Nonetheless, though supported by new fundamental tools, it is of the utmost importance for anesthesiologists to have a deep knowledge of the brachial plexus and of the topographic anatomy, on which the two first chapters are focused.
Contents
1. Anatomy of the Brachial Plexus -- 2. Topographical Anatomy -- 3. Anatomy of the Cevical Plexus -- 4. The Anesthetic Line -- 5. Electrical Nerve Stimulation and Percutaneous Identification of the Target -- 6. Supraclavicular Brachial Plexus Block Techniques -- 7. Ultrasound-Guided Interscalene and Supraclavicular Blocks -- 8.Complications of Supraclavicular Techniques -- 9. Infraclavicular Brachial Plexus Block -- 10. Axillary Brachial Plexus Block -- 11. Truncular Blocks -- 12. Intravenous Regional Anesthesia -- 13. Sedation in Regional Anesthesia -- 14. Perineural Adjuvants for Postoperative Analgesia -- 15. Postoperative Analgesia -- 16. Stellate Ganglion Block.
Format
e-Book
Location
Online
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Biochemistry for Anesthesiologists and Intensivists

https://libcat.nshealth.ca/en/permalink/provcat45100
Fernando Alemanno, editor. --Cham: Springer , c2020.
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This book discusses and explains the importance of biochemistry knowledge in understanding what happens to patients during anesthesia and/or to those being in intensive care. Anesthesiological and intensive care practice require a detailed biochemistry knowledge to avoid onset of complications and/or to deal with unexpected events promptly and appropriately. The book is intended for anesthesiologists, intensivists, anesthesia teachers, anesthesia trainees and residents.
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Other Authors
Alemanno, Fernando
Responsibility
Fernando Alemanno, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xiv, 250 p.) : 65 illus., 22 illus. in color
ISBN
9783030267216
9783030267209 (Print ed.)
9783030267223 (Print ed.)
9783030267230 (Print ed.)
Subjects (MeSH)
Anesthesia
Anesthetics - adverse effects
Anesthetics - pharmacology
Biochemical Phenomena
Critical Care
Specialty
Anesthesiology
Biochemistry
Abstract
This book discusses and explains the importance of biochemistry knowledge in understanding what happens to patients during anesthesia and/or to those being in intensive care. Anesthesiological and intensive care practice require a detailed biochemistry knowledge to avoid onset of complications and/or to deal with unexpected events promptly and appropriately. The book is intended for anesthesiologists, intensivists, anesthesia teachers, anesthesia trainees and residents.
Contents
1. Enzymes and Coenzymes (A Brief, Boring but Necessary Preamble) -- 2. Anaerobic Glycolysis or Embden–Meyerhof Pathway -- 3. Tricarboxylic Acids Cycle or Krebs Cycle -- 4. Glutamate – GABA Collateral Cycle -- 5. Hexose-Monophosphate Shunt or Horecker Cycle (The Sleep Pathway) -- 6. Neurotransmitters -- 7. The Blood-Brain Barrier (BBB) -- 8. Shock -- 9. Cerebral Edema -- 10. The Pulmonary Surfactant -- 11. When the Mind Does Not Work As It Should -- 12. Thiamine (Vitamin B1) -- 13. Normobaric Oxygen Therapy (NBO) -- 14. Acid-Base Equilibrium -- 15. Theories of Narcosis -- 16. Local Anaesthetics -- 17. Perineural Adjuvants -- 18. The Grand Design -- 19. Epilogue and Farewell.
Format
e-Book
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Online
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Biologics in General Medicine

https://libcat.nshealth.ca/en/permalink/provcat28498
edited by Wolf-Henning Boehncke, Heinfried H. Radeke. --Berlin, Heidelberg: Springer-Verlag , c2007.
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Online
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Author
Boehncke, Wolf-Henning
Other Authors
Radeke, Heinfried H
Responsibility
edited by Wolf-Henning Boehncke, Heinfried H. Radeke
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2007
ISBN
9783540290186
Subjects (MeSH)
Biological Agents - pharmacology
Immunomodulation
Adjuvants, Immunologic
Technology, Pharmaceutical - methods
Subjects (LCSH)
Pharmacy
Immunology
Format
e-Book
Location
Online
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Biologics to Treat Substance Use Disorders : Vaccines, Monoclonal Antibodies, and Enzymes

https://libcat.nshealth.ca/en/permalink/provcat39905
Ivan D. Montoya, editor. (1st ed.) --Cham: Springer , c2016.
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This book is a scientific compendium documenting the state of the art in the discovery and development of vaccines, monoclonal antibodies, and enzymes for the treatment of Substance Use Disorders (SUDs). The book gives detailed consideration to some of the most cutting edge topics in addiction medicine, including vaccines for nicotine, cocaine, heroin, and methamphetamine dependence; monoclonal antibodies against cocaine, methamphetamine, and phencyclidine; and the enzymes butyrylcholinesterase…
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Montoya, Ivan D
Responsibility
Ivan D. Montoya, editor
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xvi, 453 p. : 104 illus., 57 illus. in color)
ISBN
9783319231501
9783319231495 (print ed.)
Subjects (MeSH)
Addiction Medicine - methods
Antibodies, Monoclonal
Biological Products
Enzymes - therapeutic use
Substance-Related Disorders - drug therapy
Vaccines
Abstract
This book is a scientific compendium documenting the state of the art in the discovery and development of vaccines, monoclonal antibodies, and enzymes for the treatment of Substance Use Disorders (SUDs). The book gives detailed consideration to some of the most cutting edge topics in addiction medicine, including vaccines for nicotine, cocaine, heroin, and methamphetamine dependence; monoclonal antibodies against cocaine, methamphetamine, and phencyclidine; and the enzymes butyrylcholinesterase and cocaine esterase. In addition, the text covers a wide range of new strategies designed to optimize the development and efficacy of biologics. Unlike any other resource, this book reviews how biologics offer exciting new therapeutic opportunities for various psychiatric conditions. Written by experts in the field, Biologics to Treat Substance Use Disorders is as an authoritative reference for psychiatrists, psychologists, and all other medical professionals working with patients suffering from Substance Use Disorders.
Contents
1 Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes -- Part I. Vaccines -- 2 Therapeutic Vaccines for Treating Nicotine Addiction -- 3 Vaccines for Treating Cocaine Use Disorders -- 4 Vaccines for Opioid Addiction -- 5 Vaccines for Methamphetamine Use Disorder -- 6 Cocaine and HIV Infection -- Part II. Monoclonal Antibodies -- 7 Monoclonal Antibodies -- 8 Anti-cocaine Monoclonal Antibodies -- 9 Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse -- Part III. Enzymes -- 10 Enzyme-Based Cocaine Pharmacotherapies: Current Status and Projections for the Future -- 11 Viral Gene Transfer of Enzymes -- 12 Cocaine Hydrolases Designed from Butyrylcholinesterase -- Part IV. Strategies to Optimize the Development of Biologics to Treat Addictions -- 13 Adenovirus-Based Vaccines for the Treatment of Substance Use Disorders -- 14 Nanoparticle-Based Nicotine Vaccine -- 15 Exploration of DNA Nanostructures for Rational Design of Vaccines -- 16 Adjuvants for Substance Abuse Vaccines -- 17 Skin Vaccination Against Nicotine Addiction -- 18 Hapten Design for Anti-addiction Vaccine Development -- 19 B Cell Mechanisms Underlying Vaccine Efficacy Against Drugs of Abuse -- Part V. Practical Considerations -- 20 Practical Considerations for the Development of Vaccines Against Drugs of Abuse -- 21 Ethical Considerations of Biologics to Treat Substance Use Disorders.
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e-Book
Location
Online
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Clinical and Basic Immunodermatology

https://libcat.nshealth.ca/en/permalink/provcat41299
Anthony A. Gaspari, Stephen K. Tyring, Daniel H. Kaplan, editors. (Second edition) --Cham: Springer , 2017.
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This book is an in-depth and user-friendly reference for better understanding immune-mediated skin diseases and their therapies. The focus is on the needs of the physician, resident, or student to understand the pathophysiology of the disease as well as the mechanisms of action of the therapies. Clinical and Basic Immunodermatology, Second Edition is an effective teaching tool that has practical applications for use on a daily basis. It is a valuable resource for practicing dermatologists, derm…
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Gaspari, Anthony A
Tyring, Stephen K
Kaplan, Daniel H
Responsibility
Anthony A. Gaspari, Stephen K. Tyring, Daniel H. Kaplan, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xvi, 895 pages) : 183 illus., 172 illus. in color
ISBN
9783319297859
9783319297835 (print ed.)
Subjects (MeSH)
Skin Diseases - immunology
Skin Diseases - pathology
Skin Diseases - therapy
Abstract
This book is an in-depth and user-friendly reference for better understanding immune-mediated skin diseases and their therapies. The focus is on the needs of the physician, resident, or student to understand the pathophysiology of the disease as well as the mechanisms of action of the therapies. Clinical and Basic Immunodermatology, Second Edition is an effective teaching tool that has practical applications for use on a daily basis. It is a valuable resource for practicing dermatologists, dermatology residents and students, and healthcare workers in related fields.
Contents
Concepts of Fundamental Importance for Understanding Skin Disease -- Cytokines and Chemokines -- Innate and Adaptive Immunity -- Neuroimmunology -- Stress and Immunity -- Toll-Like Receptors -- Conventional and Unconventional T Cells -- Complement System -- Cutaneous Dendritic Cells in Health and Disease -- Antimicrobial Peptides -- Photoimmunology -- Angiogenesis for the Clinician -- Common Skin Diseases -- Contact Dermatitis: Allergic and Irritant -- Atopic Dermatitis -- Psoriasis -- The Immunology of Acne -- Nonmelanoma Skin Cancer -- Immunobiology and Immune-Based Therapies of Melanoma -- Drug Eruptions -- Cutaneous Vasculitis -- Immunodermatology and Viral Skin Infection -- HIV Disease and AIDS -- Bacterial Infections -- Parasitic Infections -- Fungal Infections -- Cutaneous T-Cell Lymphoma -- Graft-Versus-Host Disease -- Allergic Urticaria -- Immunopharmacology -- Biologic Therapies for Inflammatory Disease -- Topical Immune Response Modifiers: Adjuvants -- Topical Immune Response Modifiers: Antiinflammatories -- Traditional Immune-Modulating Drugs -- Topical Corticosteroids -- Vaccines -- Intravenous Immunoglobulins -- Autoimmunity, Immunodeficiency, and Immune Çö Associated Dermatoses -- Novel Approach to the Evaluation of Primary Immunodeficiencies -- Iatrogenic Immunodeficiency and Skin Disease -- Granulomatosis -- Vitiligo Vulgaris -- Alopecia Areata -- Cutaneous Lupus Erythematosus -- Fibrotic Skin Diseases -- Pemphigus Family of Diseases -- The Pemphigoid Spectrum -- Epidermolysis Bullosa Acquisita -- Immunoglobulin A Dermatoses.
Format
e-Book
Location
Online
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Essentials of Regional Anesthesia

https://libcat.nshealth.ca/en/permalink/provcat42890
edited by Alan David Kaye, Richard D. Urman, Nalini Vadivelu. (Second edition) --Cham: Springer , c2018.
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The management of pain can often be achieved by medications, physical therapies, or by various procedural techniques that have evolved in recent decades. With the trend towards more outpatient surgeries and less invasive surgeries to decrease perioperative risk, perioperative time, and costs, the practice of anesthesia is evolving to utilize regional anesthesia techniques both for inpatients and outpatients. Regional anesthesia is being performed for outpatient surgeries, obstetric anesthesia, …
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Kaye, Alan David
Urman, Richard D.
Vadivelu, Nalini
Responsibility
edited by Alan David Kaye, Richard D. Urman, Nalini Vadivelu
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xxiii, 725 p.) : 322 illus., 239 illus. in color
ISBN
9783319748382
9783319748375 (print ed.)
9783319748399 (print ed.)
Subjects (MeSH)
Anesthesia, Conduction
Specialty
Anesthesiology
Abstract
The management of pain can often be achieved by medications, physical therapies, or by various procedural techniques that have evolved in recent decades. With the trend towards more outpatient surgeries and less invasive surgeries to decrease perioperative risk, perioperative time, and costs, the practice of anesthesia is evolving to utilize regional anesthesia techniques both for inpatients and outpatients. Regional anesthesia is being performed for outpatient surgeries, obstetric anesthesia, trauma, chronic pain states, and for acute post-operative pain management. Therefore, it is paramount for physicians and nurses practicing anesthesia to understand the essentials of regional anesthesia, its evolving techniques, and appropriate utilization of modern equipment and technology to provide care safely. Essentials of Regional Anesthesia, Second edition, is a concise, up-to-date, evidence-based handbook that enables every resident, physician and nurse to understand the basics of regional anesthesia and the standard of care guidelines for the practice of regional anesthesia in a comprehensive fashion. This new edition includes: Updated and new chapters on Ambulatory, Critical Care, and Obstetrics topics, Full color, clear, detailed, anatomic drawings, Clinically relevant, practical aspects of regional anesthesia International contributing authors who are experts in their field, Latest ultrasound techniques and images. Review of 1st edition: "There are many books available on regional anesthesia, and the trend is either to focus on illustrations, forgoing any discussion, or on text descriptions, making them bulky and hard to read. This book maintains that perfect balance between text and illustrations. It is truly a master companion book on regional anesthesia." (Tariq M. Malik, Doody's Book Reviews, April, 2012).
Contents
Part I General Principles of Regional Anesthesia Practice -- Chapter 1. General Considerations for Regional Anesthesia Practice -- Chapter 2. Economic Impact, Cost, and Reimbursement Issues -- Chapter 3. Training and Education of a Physician for Regional Anesthesia -- Part II Basics and Clinical Practice in Regional Anesthesia -- Chapter 4. The Anatomy of Pain and Its Implications for Regional Anesthesiology Practice -- Chapter 5. Local Anesthetics and Adjuvants -- Chapter 6. Monitoring and Sedation in Regional Anesthesia -- Chapter 7. Anticoagulation and Regional Anesthesia Concerns -- Chapter 8. Regional Anesthesia in the Community Practice Setting -- Part III Ultrasound-Assisted Nerve Blocks -- Chapter 9. Ultrasound-Guided Peripheral Nerve Blockade -- Part IV Continuous Regional Analgesia and Techniques for Regional Anesthesia -- Chapter 10. Equipment and Clinical Practice: Aids to Localization of Peripheral Nerves -- Chapter 11. Neuraxial Blockade: Subarachnoid Anesthesia -- Chapter 12. Neuraxial Blockade: Epidural Anesthesia -- Chapter 13. Peripheral Nerve Blocks for the Lower Extremity -- Chapter 14. Regional and Topical Anesthesia for Endotracheal Intubation -- Chapter 15. Regional Anesthetic Techniques for the Pediatric Patient -- Chapter 16. Head and Neck Regional Anesthesia -- Chapter 17. Upper Extremity Nerve Blocks -- Chapter 18. Local Anesthesia of the Masticatory Region -- Chapter 19. Regional Anesthetic Techniques for Foot Surgery -- Chapter 20. Selective Regional Anesthesia Options in Surgical Subspecialties -- Chapter 21. Obstetric Anesthesiology -- Chapter 22. Acute Situations: Trauma in Surgical Specialties -- Chapter 23. Preemptive Analgesia, Regional Anesthesia and Prevention of Chronic Postoperative Pain -- Chapter 24. Transverse Abdominal Plane, Pectoral and Serratus Plane, and Quadratus -- Part V Regional Anesthesia and Subspecialties -- Chapter 25. Outpatient Surgery -- Chapter 26. Regional Anesthesia in the Critical Care Setting -- Part VI Regional Anesthesia for Chronic Situations -- Chapter 27. Regional Anesthesia for Chronic Pain -- Chapter 28. Regional Anesthesia Considerations for Chronic Non-cancer Pain -- Chapter 29. Malignant Pain -- Chapter 30. Regional Anesthesia and Cardiovascular Disease -- Chapter 31. Regional Anesthesia in the Patient with Preexisting Neurological Disease -- Chapter 32. Sympathetic Blockade -- Part VII Outcomes Studies in Regional Anesthesia -- Chapter 33. Outcome Studies and Infection Control in Regional Anesthesia -- Chapter 34. Acute Pain Management -- Chapter 35. Regional Anesthesia for Chronic Disease States -- Chapter 36. Intravenous Regional Anesthesia -- Chapter 37. Pediatric Pain -- Part VIII Future Trends in Regional Anesthesia -- Chapter 38. Future Trends in Equipment -- Chapter 39. Future Trends in Regional Anesthesia Techniques.
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e-Book
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Online
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Imaging and Focal Therapy of Early Prostate Cancer

https://libcat.nshealth.ca/en/permalink/provcat41634
Thomas J. Polascik, editor. (Second edition) --Cham: Springer , 2017.
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This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablat…
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Other Authors
Polascik, Thomas J
Responsibility
Thomas J. Polascik, editor
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xx, 483 pages) : 133 illus., 97 illus. in color
Series Title
Current clinical urology
ISBN
9783319499116
9783319499109 (print ed.)
ISSN
2197-7194
Subjects (MeSH)
Ablation Techniques - methods
Early Diagnosis
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - therapy
Abstract
This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc.) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians--residents, fellows, nurses and allied professionals--and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.
Contents
Evolution in the Concept of Focal Therapy: the Story of Breast Cancer and Prostate Cancer -- Targeted Therapy for Localized Kidney Cancer -- Focal Therapy for Prostate Cancer: A Guide for Patients -- Low-Risk Prostate Cancer in North America: Rationale, Uptake, and Limitations of Active Surveillance and Opportunities for Focal Therapy -- Focal Therapy and Active Surveillance in Europe -- Focal Therapy and Active Surveillance of Prostate Cancer in East and Southeast Asia -- Pathologic Rationale for Focal Therapy of Prostate Cancer: Elucidating Tumor Characteristics and Biology -- Identifying and Characterizing the Index Lesion -- Utilizing Biopsy-Based Genomic Assays to Risk-Stratify Patients -- Patient Selection for Focal Therapy of Prostate Cancer -- Prostate Focal Therapy: Definitions and Common Terminology -- Reading and Reporting Standards: The Prostate Imaging Reporting And Data System Çô What Is It and What Can It Do? -- Role of Magnetic Resonance Imaging in Prostate Cancer Assessment -- Optimizing Multiparametric Magnetic Resonance Imaging for a Focal Therapy Practice: Quality Improvement -- Acoustic Radiation Force Impulse Imaging for Targeting: Correlation with Histology -- In-Bore Magnetic Resonance Imaging-Targeted Biopsy -- Multiparametric MRI-TRUS Fusion Biopsy, Outcomes, and Commercial Systems -- Detecting, Localizing, and Treating the Multiparametric Magnetic Resonance Imaging Invisible Lesion: Utilizing Three-Dimensional Transperineal Mapping -- Multiparametric Transrectal Ultrasound Biopsy -- Robotic Magnetic Resonance Imaging Targeting for Biopsy and Therapy -- In-Bore Transperineal Magnetic Resonance Imaging-Guided Laser Ablation -- Focal Cryoablation -- Photodynamic Therapy for Early Prostate Cancer -- High-Intensity Focused Ultrasound -- Transrectal Laser Focal Therapy of Prostate Cancer -- Focal Therapy for Prostate Cancer: a Molecular Biology Approach with TRAIL -- Focal Therapy for Anterior Cancers (Originated from Transition Zone) -- The Story of Adjuvants to Boost the Performance of Cryoablation -- 5-Alpha-Reductase Inhibition as a Secondary Preventive Strategy -- Measuring Patient-Based Outcomes: Setting Realistic Expectations When Balancing Functional Outcomes with Cancer Control -- Pathologic Assessment and Implications Following Focal Therapy of Prostate Cancer -- Post-Treatment Surveillance Using Multiparametric Magnetic Resonance Imaging -- Determining Focal Therapy Failure and Salvage Options.
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e-Book
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Online
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Immunotherapy for Pediatric Malignancies

https://libcat.nshealth.ca/en/permalink/provcat43239
Juliet C. Gray, Aurélien Marabelle, editors. --Cham: Springer , c2018.
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This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed,…
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Gray, Juliet C
Marabelle, Aurélien
Responsibility
Juliet C. Gray, Aurélien Marabelle, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 297 p.) : 29 illus., 27 illus. in color
ISBN
9783319434865
9783319434841 (print ed.)
9783319434858 (print ed.)
9783319828374 (print ed.)
Subjects (MeSH)
Antibodies, Monoclonal - therapeutic use
Child
Immunotherapy - methods
Neoplasms - therapy
Specialty
Medical Oncology
Pediatrics
Regenerative Medicine
Abstract
This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy. Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.
Contents
1. Introduction to Pediatric Cancer Immunotherapy -- 2. Overcoming Immune Suppression in the Tumor Microenvironment: Implications for Multi-modal Therapy -- 3. Allogeneic Stem Cell Transplantation -- 4. Overview of Monoclonal Antibody Therapies -- 5. Monoclonal Antibodies Targeting Hematological Malignancies -- 6. Monoclonal Antibodies Directly Targeting Antigens on Solid Tumours -- 7. Monoclonal Antibodies Targeting the Immune System -- 8. Adoptive T Cell Therapies for Children’s Cancers -- 9. NK Cell and NKT Cell Immunotherapy -- 10. Cancer Vaccines in Pediatrics -- 11. Immune Adjuvants and Cytokine Therapies -- 12. Immune Biomarkers in Paediatric Malignancies -- 13. Future Perspectives.
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e-Book
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Online
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Immunotherapy of Cancer : An Innovative Treatment Comes of Age

https://libcat.nshealth.ca/en/permalink/provcat40389
Yoshiyuki Yamaguchi, editor. (1st ed.) --Tokyo: Springer Japan , c2016.
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This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy ha…
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Yamaguchi, Yoshiyuki
Responsibility
Yoshiyuki Yamaguchi, editor
Edition
1st ed.
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (ix, 358 p. : 46 illus., 8 illus. in color)
ISBN
9784431550310
9784431550303 (print ed.)
Subjects (MeSH)
Adjuvants, Immunologic - therapeutic use
Cancer Vaccines
Immunotherapy
Neoplasms - immunology
Neoplasms - therapy
Abstract
This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.
Contents
Part I. Overview, History, Classification -- 1. Overview of Current Cancer Immunotherapy -- Part II. BRMs and Crude Agents -- 2. Bacterial Preparations -- 3. Polysaccharides -- 4. BCG -- Part III. Cytokines -- 5. ø-T Cells -- 6. NKT Cell-Based Immunotherapy -- 7. Natural Killer Cells -- 8. þ T Cell-Based Cancer Immunotherapy -- 9. Genetically engineered T cells -- Part IV. Vaccine Therapy -- 10. Peptide Vaccine -- 11. Personalized Peptide Vaccine -- 12. WT1 Peptide Vaccine for the Treatment of Malignancies -- 13. Protein vaccine -- 14. Dendritic Cell-Based Vaccine for Cancer -- Part V. Immunoadjuvants -- 15. CpG Motif -- 16. Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy -- 17. Novel Adjuvants -- Part VI. Immunocheckpoints -- 18. Anti-CTLA-4 Ab -- 19. Anti-PD-1, PD-L1 Ab -- 20. Novel Targets of Immune Inhibitory and Stimulatory Co-signals -- Part VII. Regulation of Immunosuppression -- 21. Regulatory T Cells -- 22. MDSC: Myeloid-Derived Suppressor Cells -- Part VIII. Immune-Related Response Criteria and Guidance for Clinical Trials -- 23. Immune-Related Response Criteria and Guidance for Clinical Trials -- Part IX. Personalized Immunotherapy -- 24. Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy.
Format
e-Book
Location
Online
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Masterful Care of the Aging Athlete : A Clinical Guide

https://libcat.nshealth.ca/en/permalink/provcat42607
Vonda J. Wright, Kellie K. Middleton, editors. --Cham: Springer , c2018.
Available Online
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Location
Online
This unique text focuses exclusively on the ever-growing population of aging and masters athletes, both professional and amateur, presenting both operative and nonoperative management strategies for the range of sports-related injuries. The book is thematically divided into three sections. Part I describes the science of musculoskeletal aging and the benefits of remaining active as we age, including proper nutrition, supplements and medical therapies and adjuvants. Injuries common to the master…
Available Online
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Other Authors
Wright, Vonda J.
Middleton, Kellie K.
Responsibility
Vonda J. Wright, Kellie K. Middleton, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (x, 225 p.) : 21 illus., 6 illus. in color
ISBN
9783319162232
9783319162225 (print ed.)
9783319162249 (print ed.)
Subjects (MeSH)
Aged
Aging - physiology
Athletes
Athletic Injuries - therapy
Orthopedic Procedures
Specialty
Geriatrics
Sports Medicine
Abstract
This unique text focuses exclusively on the ever-growing population of aging and masters athletes, both professional and amateur, presenting both operative and nonoperative management strategies for the range of sports-related injuries. The book is thematically divided into three sections. Part I describes the science of musculoskeletal aging and the benefits of remaining active as we age, including proper nutrition, supplements and medical therapies and adjuvants. Injuries common to the masters athlete are presented in part II, from the upper and lower extremities to the hips and spine, with special considerations for these injuries and treatments noted. Recommendations for how to thrive as a masters athlete comprise the final section, including return to sport, injury prevention and exercise as medicine. An ideal resource for clinicians who treat active adults who won't slow down, Masterful Care of the Aging Athlete is a compilation of clinical, technical and research approaches aimed at keeping active people moving, returning them to sport rapidly and durably and protecting them from a sedentary lifestyle.
Contents
Part I. The Science of Musculoskeletal Aging and the Benefits of Being a Masters Athlete -- 1. The New Science of Aging -- 2. The New Science of Musculoskeletal Aging in Bone, Muscle, and Tendon/Ligament -- 3. Structural Brain Benefits of Maintained Fitness -- 4. Psychological and/or Mental Health Benefits of Maintaining Activity and Exercise -- 5. Maximizing Nutrition and Supplements for Masters Athletes -- 6. Antiaging and Performance-Enhancing Drugs -- 7. Injectable, Biologics, and Stem Cells -- Part II. Common Injuries in Masters Athletes, Treatment Considerations, and Return to Sports -- 8. Knee Injuries: Conservative Management, Operative Management, and Return to Sport -- 9. Common Hip Injuries: Conservative Management -- 10. Shoulder Injuries: Conservative Management, Operative Management, and Return to Sport -- 11. The Management of Distal Radius Fractures in the Aging Athlete -- 12. Foot and Ankle: Conservative Management, Operative Management, and Return to Sport -- 13. Spine Injuries: Conservative Managment, Operative Management and Return to Sport -- Part III. Thriving as a Masters Athlete -- 14. Return to Sport Following Total Joint Arthroplasty -- 15. Maximizing Performance and Preventing Injury in Masters Athletes -- 16. An Exercise Prescription for Healthy Active Aging -- 17. Importance of Core and Gluteus Strengthening -- 18. Longevity and Epigenetics.
Format
e-Book
Location
Online
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Meyler's side effects of drugs used in cancer and immunology

https://libcat.nshealth.ca/en/permalink/provcat32091
editor, J.K. Aronson. --Amsterdam ; London: Elsevier Science , c2010.
Available Online
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Access
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Location
Online
Elsevier now offers a series of derivative works based on the acclaimed Meyler's Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician.
Available Online
View e-Book
Other Authors
Aronson, J. K
Meyler, L
Responsibility
editor, J.K. Aronson
Alternate Title
Side effects of anticancer drugs
Place of Publication
Amsterdam ; London
Publisher
Elsevier Science
Date of Publication
c2010
Physical Description
1 online resource (viii, 774 p.)
ISBN
9780444532671 (hbk.)
Subjects (MeSH)
Antineoplastic Agents - adverse effects
Adjuvants, Immunologic - adverse effects
Immunosuppressive agents - adverse effects
Drug Interactions
Subjects (LCSH)
Cytostatic Agents - adverse effects
Anti-Allergic Agents - adverse effects
Drugs - Side effects
Cancer - Chemotherapy - Complications
Abstract
Elsevier now offers a series of derivative works based on the acclaimed Meyler's Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician.
Access
Registration required for PDF access.
Format
e-Book
Location
Online
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Minimally Invasive Spine Surgery : Surgical Techniques and Disease Management

https://libcat.nshealth.ca/en/permalink/provcat44775
Frank M. Phillips, Isador H. Lieberman, David W. Polly Jr., Michael Y. Wang, editors. (Second edition) --Cham: Springer , c2019.
Available Online
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Location
Online
The use of minimally invasive spine surgery (MISS) has grown rapidly over the last decade and remains the fastest growing area in spine surgery. Now in a revised and expanded second edition including 19 new chapters, this comprehensive textbook provides an updated presentation of the field of MISS, highlighting surgical techniques and clinical outcomes as well as providing a unique focus on how these techniques are applied for specific spinal conditions. Minimally Invasive Spine Surgery, Second…
Available Online
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Other Authors
Phillips, Frank M.
Lieberman, Isador H.
Polly Jr., David W.
Wang, Michael Y.
Responsibility
Frank M. Phillips, Isador H. Lieberman, David W. Polly Jr., Michael Y. Wang, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xviii, 702 p.) : 352 illus., 243 illus. in color
ISBN
9783030190071
9783030190064 (Print ed.)
9783030190088 (Print ed.)
9783030190095 (Print ed.)
Subjects (MeSH)
Minimally Invasive Surgical Procedures - methods
Orthopedic Procedures - methods
Spine - surgery
Specialty
Orthopedic Procedures
Abstract
The use of minimally invasive spine surgery (MISS) has grown rapidly over the last decade and remains the fastest growing area in spine surgery. Now in a revised and expanded second edition including 19 new chapters, this comprehensive textbook provides an updated presentation of the field of MISS, highlighting surgical techniques and clinical outcomes as well as providing a unique focus on how these techniques are applied for specific spinal conditions. Minimally Invasive Spine Surgery, Second Edition includes detailed discussions of enabling technologies, surgical techniques, approaches to specific diseases and conditions, a new section on out-patient/ambulatory spine surgery, and strategies to manage the unique risks and complications associated with MISS. Each chapter, whether revised or new, is formatted in a consistent manner, including bulleted key learning points as well as review questions, pearls and pitfalls, and generous illustrations and intra-operative photographs. Written and edited by thought leaders in the field, this user-friendly textbook will be an essential resource for orthopedic and neurosurgery trainees, as well as a valuable reference and review for spine surgeons and health care professionals who treat the spine.
Contents
Part I. Introduction to Minimally Invasive Spine Surgery -- History and Evolution of Minimally Invasive Spine Surgery -- Philosophy and Biology of Minimally Invasive Spine Surgery -- Economics of Minimally Invasive Spine Surgery -- Learning Curve for Minimally Invasive Spine Surgery -- The Role of MIS Spine Surgery in Global Health: A Development Critique -- Part II. Enabling Technologies for Minimally Invasive Spine Surgery -- Microscopes and Endoscopes -- Intraoperative Neurophysiology Monitoring -- Image Guidance in Minimally Invasive Spine Surgery -- Robotic-Assisted Spine Surgery -- Fusion Biologics and Adjuvants in Minimally Invasive Spine Surgery -- Use of Stem Cells in Spinal Treatments -- Lasers -- Radiation Exposure and Avoidance in Minimally Invasive Spine Surgery -- Part III. Surgical Techniques: Minimally Invasive Decompression -- Posterior Cervical Decompression -- Thoracic Decompression -- Lumbar Decompression Using a Tubular Retractor System -- Endoscopic Decompression -- Interspinous and Interlaminar Devices for Decompression -- Minimally Invasive Posterior Cervical Fixation -- Percutaneous Pedicle Screws -- Minimally Invasive Facet Screw Fixation -- Minimally Invasive Transforaminal Lumbar Interbody Fusion -- Minimally Invasive Midline Pars-Cortical Screw Techniques -- Minimally Invasive Spinous Process Fixation and Fusion -- Mini-Open Anterior Lumbar Interbody Fusion -- Minimally Disruptive Lateral Transpsoas Approach for Thoracolumbar Anterior Interbody Fusion -- Anterior Column Reconstruction for Sagittal Plane Deformity Correction -- Thoracoscopic Fusion -- Pre-Psoas Approaches for Thoracolumbar Interbody Fusion -- Endoscopic Spinal Fusion -- Navigated Spinal Fusion -- Cervical Herniated Nucleus Pulposus and Stenosis -- Thoracic Herniated Nucleus Pulposus -- Lumbar Herniated Nucleus Pulposus -- Lumbar Spinal Stenosis -- Lumbar Spondylolisthesis -- Adolescent Scoliosis -- Adult Scoliosis -- Anterior Column Realignment (ACR): Minimally Invasive Surgery for the Treatment of Adult Sagittal Plane Deformity -- Thoracolumbar Spine Trauma -- Minimally Invasive Surgery for Spinal Tumors -- Pathologic Fractures -- How and When to Incorporate Minimally Invasive Surgery for Treatment of Deformity: Decision-Making -- Sacroiliac Joint Dysfunction -- Minimally Invasive Spine Surgery in the Elderly -- Part IV. Surgical Techniques: Minimally Invasive Fusion -- Clinical and Economic Advantages of Out-Patient Spine Surgery -- Clinical Outcomes of Outpatient Spine Surgery -- Selection of Appropriate Patients for Outpatient Spine Surgery -- Analgesia and Anesthesia to Enable Out-Patient Spine Surgery -- Postoperative Care Following Outpatient Spine Surgery -- Choice of Minimally Invasive Approaches: A Review of Unique Risks and Complications -- Minimally Invasive Spine Surgery Complications with Implant Placement and Fixation -- Neural and Dural Injury in Minimally Invasive Surgery -- Pseudarthrosis.
Format
e-Book
Location
Online
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Orofacial pain : a clinician's guide

https://libcat.nshealth.ca/en/permalink/provcat33715
Nalini Vadivelu, Amarender Vadivelu, Alan David Kaye, editors. --Cham, Switzerland: Springer , c2014.
Available Online
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Location
Online
Available Online
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Other Authors
Vadivelu, Nalini
Vadivelu, Amarender
Kaye, Alan David
Responsibility
Nalini Vadivelu, Amarender Vadivelu, Alan David Kaye, editors
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xii, 181 pages)
ISBN
9783319018751 (electronic bk.)
9783319018744
Subjects (MeSH)
Facial Pain - therapy
Pain Management - methods
Subjects (LCSH)
Orofacial pain
Orofacial pain - Treatment
Facial Pain
Contents
1. The Neurobiology of Orofacial Pain -- 2. Oral Health-Related Quality of Life and Facial Pain -- 3. Classification and Epidemiology of Orofacial Pain -- 4. Nociceptive Chemical Mediators in Oral Inflammation -- 5. Dental Sleep Medicine and the Use of Oral Devices -- 6. Local Anesthesia in the Orofacial Region -- 7. Analgesics and Adjuvants for the Management of Orofacial Pain Across Age Groups -- 8. Cognitive Behavioral Therapy in Pain Management -- 9. Management of Oral Ulcers and Burning Mouth Syndrome -- 10. Hypnosis and Biofeedback for Orofacial Pain Management -- 11. Headaches, Migraine, and Cluster Headache -- 12. Management of Orofacial Neuropathic Pain -- 13. Preemptive Analgesia and Multimodal Pain Management for Temporomandibular Total Joint Replacement Surgery -- 14. Masticatory Myofascial Pain.
Format
e-Book
Location
Online
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