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Cardiovascular Calcification and Bone Mineralization

https://libcat.nshealth.ca/en/permalink/provcat45438
Elena Aikawa, Joshua D. Hutcheson, editors. --Cham: Humana Press , c2020.
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The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book …
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Other Authors
Aikawa, Elena
Hutcheson, Joshua D.
Responsibility
Elena Aikawa, Joshua D. Hutcheson, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2020
Physical Description
1 online resource (xxi, 563 p.) : 108 illus., 102 illus. in color
Series Title
Contemporary cardiology
ISBN
9783030467258
9783030467241 (Print ed.)
9783030467265 (Print ed.)
9783030467272 (Print ed.)
ISSN
2196-8969
Subjects (MeSH)
Calcification, Physiologic - physiology
Vascular Calcification - physiopathology
Specialty
Cardiology
Osteology
Physiology
Abstract
The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.
Contents
Part I. Cardiovascular Calcification -- 1. The History of Cardiovascular Calcification -- 2. Basic Pathology of Arterial and Valvular Calcification in Humans -- 3. Developmental Pathways and Aortic Valve Calcification -- 4. Differential Mechanisms of Arterial and Valvular Calcification - 5. Calcifying Extracellular Vesicles: Biology, Characterization, and Mineral Formation -- 6. Role of Biomechanical Stress and Mechanosensitive miRNAs in Calcific Aortic Valve Disease -- 7. The Role of Chronic Kidney Disease in Ectopic Calcification -- 8. The Role of Calcification in Peripheral Artery Disease -- 9. Bioprosthetic Heart Valve Calcification: Clinicopathologic Correlations, Mechanisms, and Prevention -- Part II. Ectopic Calcification -- 10. Electron Microscopy for the Characterization of Soft Tissue Mineralization -- 11. Cardiovascular Calcification in Hutchinson-Gilford Progeria and Correlation with Age-Related Degenerative Calcification -- 12. Calcinosis in Scleroderma -- 13. Placental Calcification: Long-standing Questions and New Biomedical Research Directions -- 14. Heterotopic Ossification Following Traumatic Blast Injury -- Part III. Bone Mineralization -- 15. The Paradoxical Relationship Between Skeletal and Cardiovascular Mineralization -- 16. Cellular Contributors to Bone Homeostasis -- 17. Bone Biology, Modeling, Remodeling, and Mineralization -- 18. Osteoclasts in Cardiovascular Calcification -- Part IV. Imaging, Treatment, and Target Discovery -- 19. Imaging Cardiovascular Calcification Activity with 18F-Fluoride PET -- 20. The Role of Elastin Degradation in Vascular Calcification: Possibilities to Repair Elastin and Reverse Calcification -- 21. Clinical Trials and Calcification-Based Treatment Decisions -- 22. Surgical Versus Transcatheter Aortic Valve Replacement -- 23. Target Discovery in Calcification Through Omics and Systems Approaches.
Format
e-Book
Location
Online
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Chronic Hepatitis C Virus : Advances in Treatment, Promise for the Future

https://libcat.nshealth.ca/en/permalink/provcat30939
Mitchell L. Shiffman, editor. --New York, NY: Springer , c2012.
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Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade wi…
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Other Authors
Shiffman, Mitchell L
Responsibility
Mitchell L. Shiffman, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xvi, 332 p. : 53 ill., 33 ill. in color)
ISBN
9781461411925
Subjects (MeSH)
Antiviral Agents - therapeutic use
Hepacivirus - pathogenicity
Hepatitis C, Chronic - therapy
Liver Transplantation
Specialty
Gastroenterology
Virology
Abstract
Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.
Contents
Epidemiology of Chronic HCV -- Acute HCV -- Assessing the Progression of Chronic HCV to Cirrhosis -- Chronic HCV and Steatosis -- Chronic HCV and Hepatocellular Carcinoma -- Extrahepatic Manifestations of Chronic HCV -- Chronic HCV and HIV Co-infection -- Chronic HCV in Patients with Renal Disease -- Does Treatment Alter the Natural History of Chronic HCV -- Treatment with Interferon and Ribavirin -- Immune Modulators and Other Agents -- Measuring HCV RNA and Assessing Virologic Response -- Response Guided Therapy -- Managing the Side Effects of Therapy -- The Genetics of Virologic Response -- Maintenance Therapy with Peginterferon -- Anti-viral Targets in HCV -- Mutations and the Development of Anti-viral Resistance -- Peginterferon, Ribavirin and Anti-viral Triple Therapy -- Treating Chronic HCV without Interferon and/or Ribavirin -- Maintenance Therapy with Oral Anti-viral Agents -- Natural History of Chronic HCV after Liver Transplantation -- Use of HCV Positive Organs in Patients with and without Chronic HCV -- Treating HCV Prior to Liver Transplantation -- Treating HCV after Liver Transplantation.
Format
e-Book
Location
Online
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Decoding anorexia : how breakthroughs in science offer hope for eating disorders

https://libcat.nshealth.ca/en/permalink/provcat31304
Carrie Arnold. --New York, NY: Routledge , c2013.
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Decoding Anorexia is the first and only book to explain anorexia nervosa from a biological point of view. Its clear, user-friendly descriptions of the genetics and neuroscience behind the disorder is paired with first person descriptions and personal narratives of what biological differences mean to sufferers. Author Carrie Arnold, a trained scientist, science writer, and past sufferer of anorexia, speaks with clinicians, researchers, parents, other family members, and sufferers about the facto…
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Author
Arnold, Carrie
Responsibility
Carrie Arnold
Place of Publication
New York, NY
Publisher
Routledge
Date of Publication
c2013
Physical Description
204 p.
ISBN
9781136201585 (PDF ebook)
Subjects (MeSH)
Anorexia Nervosa - psychology
Anorexia Nervosa - therapy
Abstract
Decoding Anorexia is the first and only book to explain anorexia nervosa from a biological point of view. Its clear, user-friendly descriptions of the genetics and neuroscience behind the disorder is paired with first person descriptions and personal narratives of what biological differences mean to sufferers. Author Carrie Arnold, a trained scientist, science writer, and past sufferer of anorexia, speaks with clinicians, researchers, parents, other family members, and sufferers about the factors that make one vulnerable to anorexia, the neurochemistry behind the call of starvation, and why it's so hard to leave anorexia behind. She also addresses: How environment is still important and influences behaviors; The characteristics of people at high risk for developing anorexia nervosa; Why anorexics find starvation "rewarding"; Why denial is such a salient feature, and how sufferers can overcome it. Carrie also includes interviews with key figures in the field that explains their work and how it contributes to our understanding of anorexia. Long thought to be a psychosocial disease of fickle teens, this book alters the way anorexia is understood and treated and gives patients, their doctors, and their family members hope.
Contents
Introduction: Off the couch and into the brain. From starving saints to dieting divas -- Interoception and the insula -- Climbing the family tree -- Anorexia's poster children -- When anorexia brings friends -- Starvation becomes obsession -- Adapted to flee famine -- Gym rats -- Stepping up to the (dinner) plate -- Oops, I did it again ... -- Standing at the buffet of life.
Format
e-Book
Location
Online
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Intermittent Hypoxia and Human Diseases

https://libcat.nshealth.ca/en/permalink/provcat30894
Lei Xi, Tatiana V. Serebrovskaya, editors. --London: Springer , c2012.
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The scientific field of intermittent hypoxia and its effects on living organisms is surrounded by divergent and controversial findings. Does the condition play pathogenic roles in disease states, such as sleep apnea, chronic pulmonary disease, cardiovascular disease and cancer? Or does exposure to intermittent hypoxia actually induce protective responses? Dealing with these long-standing controversies and new concepts, Intermittent Hypoxia and Human Diseases provides an open forum for the most…
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Other Authors
Xi, Lei
Serebrovskaya, Tatiana V
Responsibility
Lei Xi, Tatiana V. Serebrovskaya, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xi, 316 p. : 113 ill., 40 ill. in color)
ISBN
9781447129066
Subjects (MeSH)
Anoxia
Subjects (LCSH)
Cardiology
Pathology
Abstract
The scientific field of intermittent hypoxia and its effects on living organisms is surrounded by divergent and controversial findings. Does the condition play pathogenic roles in disease states, such as sleep apnea, chronic pulmonary disease, cardiovascular disease and cancer? Or does exposure to intermittent hypoxia actually induce protective responses? Dealing with these long-standing controversies and new concepts, Intermittent Hypoxia and Human Diseases provides an open forum for the most up-to-date scientific understanding of both adaptive (beneficial) and maladaptive (detrimental) responses to intermittent hypoxia and their potential pathogenic and prophylactic roles in the development and progression of major human diseases. The Editors and their extremely experienced contributors have assembled this highly disease-oriented book and all the fundamental research findings are selectively presented as mechanistic explanations of a particular human disease. It is therefore especially prepared for the interests of clinicians, allied healthcare professionals, athletic trainers, and translational medical researchers.
Contents
1. Sleep Disordered Breathing and Cardiac Arrhythmias: Role of Intermittent Hypoxia -- 2. Effects of Chronic Intermittent Hypoxia on Cardiac Rhythm Transcriptomic Networks -- 3. Intermittent Hypoxia and Atherosclerosis -- 4. Protective Effects of Chronic Intermittent Hypoxia Against Myocardial Ischemia/Reperfusion Injury -- 5. Role of Mitochondrial Permeability Transition Pore in Intermittent Hypoxia-Induced Cardiac and Neuronal Protection -- 6. Intermittent Hypoxia Alters the Function of Cardiovascular Neurons and Reflex Pathways in the Brainstem -- 7. Effect of Intermittent Hypoxia on Breathing Stability in Individuals with Sleep Apnea -- 8. Activation of Inflammatory Circulating Factors by Intermittent Hypoxia in Sleep Apnea Syndrome -- 9. Beneficial Effects of Intermittent Normobaric Hypoxia Training on Respiratory Function in Patients with Chronic Pulmonary Diseases -- 10. Effects of Intermittent Hypoxic Training on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease -- 11. Intermittent Hypoxia in Treatment of Bronchial Asthma in Childhood -- 12. Intermittent Hypoxia and Experimental Parkinson's Disease -- 13. Protective Effects of Adaptation to Hypoxia in Experimental Alzheimer's Disease -- 14. Neuroprotective Mechanisms of Intermittent Hypoxia: An In Vitro Study -- 15. Intermittent Hypoxia Training to Enhance Endurance in Elite Swimmers -- 16. Adaptation to Intermittent Hypoxia/Hyperoxia Enhances Efficiency of Exercise Training -- 17. Hypobaric Interval Hypoxia as a Non-Medication Method of Improving the Functional State of Aerospace Pilots and Astronauts -- 18. Intermittent Hypoxia Remedies Male Sub-fertility -- 19. Anticancer Effects of Intermittent Hypoxia in Acute Myeloid Leukemia -- 20. Energotropic Effects of Intermittent Hypoxia: Role of Succinate-Dependent Signaling -- 21. Intermittent Hypoxia and Health: from Evolutionary Aspects to Mitochondrial Rejuvenation -- 22. Benefits and Risks of Different Regimen of Intermittent Hypoxic Training -- 23. Individualized Intermittent Hypoxia Training: Principles and Practices -- 24. Hypoxicators: Review of the Operating Principles and Constructions -- 25. Method of Combined Intermittent Hypoxia and Surface Muscle Electrostimulation for Enhancing Peripheral Stem Cells in Humans.
Format
e-Book
Location
Online
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Invasive fungal rhinosinusitis

https://libcat.nshealth.ca/en/permalink/provcat33755
Gauri Mankekar, editor. --New Delhi: Springer , c2014.
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Incidence of invasive fungal sinusitis has been increasing over the years. The understanding of its pathophysiology has improved with newer serological tests and diagnostic methods helping in earlier diagnosis and reducing patient morbidity. It was believed earlier that invasive fungal sinusitis is seen only in immune compromised patients but clinical reports suggest otherwise. More anti-fungal drugs are being added to improve incidence of patient survival. This book aims to compile all practic…
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Other Authors
Mankekar, Gauri
Responsibility
Gauri Mankekar, editor
Place of Publication
New Delhi
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xi, 93 pages)
ISBN
9788132215301 (electronic bk.)
9788132215295
Subjects (MeSH)
Rhinitis - microbiology
Sinusitis - microbiology
Mycoses - physiopathology
Subjects (LCSH)
Sinusitis
Mycoses
Rhinitis
Siunuitis
Otorhinolaryngology
Infectious Diseases
Abstract
Incidence of invasive fungal sinusitis has been increasing over the years. The understanding of its pathophysiology has improved with newer serological tests and diagnostic methods helping in earlier diagnosis and reducing patient morbidity. It was believed earlier that invasive fungal sinusitis is seen only in immune compromised patients but clinical reports suggest otherwise. More anti-fungal drugs are being added to improve incidence of patient survival. This book aims to compile all practical information about invasive fungal sinusitis into a single volume. Therefore, busy clinicians would not have to perform exhaustive literature studies to diagnose invasive fungal sinusitis. The book aims to provide an overview of diseases which could be mistaken for invasive fungal sinusitis and discuss how the management is different. Book sections consist of clinical, microbiological, serological, pathological, radiological and pharmacological features of the disease and its management. Each section is important in today's context as it dynamically alters the management of the patient. Early clinical suspicion and rapid microbiological, pathological and radiological diagnosis with aggressive treatment with surgical debridement and medical therapy leads to favorable outcomes.
Contents
Introduction -- Classification of Fungal Sinusitis -- Epidemiology, Pathogenesis, and Risk Factors -- Clinical Features and Diagnosis -- Histopathology of Invasive Fungal Rhinosinusitis -- Microbiology in Invasive Fungal Sinusitis -- Radiology in Invasive Fungal Sinusitis -- Management of Invasive Fungal Sinusitis -- Conclusion -- Case Studies.
Format
e-Book
Location
Online
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Respiratory physiology : the essentials

https://libcat.nshealth.ca/en/permalink/provcat25328
West, John B. (9th ed.) --Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins , 2012.
Call Number
WF 102 W518r 2012
Location
Dickson Building
Halifax Infirmary
Call Number
WF 102 W518r 2012
Author
West, John B
Edition
9th ed.
Place of Publication
Philadelphia, PA
Publisher
Wolters Kluwer Health/Lippincott Williams & Wilkins
Date of Publication
2012
Physical Description
200 p.
ISBN
9781609136406
Subjects (MeSH)
Respiratory Physiological Phenomena
Contents
ch. 1 Structure and Function-How the Architecture of the Lung Subserves its Function -- ch. 2 Ventilation-How Gas Gets to the Alveoli -- ch. 3 Diffusion-How Gas Gets Across the Blood-Gas Barrier -- ch. 4 Blood Flow and Metabolism-How the Pulmonary Circulation Removes Gas from the Lung and Alters Some Metabolites -- ch. 5 Ventilation-Perfusion Relationships-How Matching of Gas and Blood Determines Gas Exchange -- ch. 6 Gas Transport by the Blood-How Gases are Moved to and from the Peripheral Tissues -- ch. 7 Mechanics of Breathing-How the Lung is Supported and Moved -- ch. 8 Control of Ventilation-How Gas Exchange is Regulated -- ch. 9 Respiratory System Under Stress-How Gas Exchange is Accomplished During Exercise, at Low and High Pressures, and at Birth -- ch. 10 Tests of Pulmonary Function-How Respiratory Physiology is Applied to Measure Lung Function.
Format
Book
Location
Dickson Building
Halifax Infirmary
Copies
2
Loan Period
3 weeks
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Shay Soker, Aleksander Skardal, editor. --Cham: Humana Press , c2018.
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Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity…
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Other Authors
Soker, Shay
Skardal, Aleksander
Responsibility
Shay Soker, Aleksander Skardal, editor
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2018
Physical Description
1 online resource (xvi, 213 p.) : 52 illus., 50 illus. in color
Series Title
Cancer drug discovery and development
ISBN
9783319605111
9783319605098 (print ed.)
9783319605104 (print ed.)
9783319868745 (print ed.)
ISSN
2196-9906
Subjects (MeSH)
In Vitro Techniques
Models, Biological
Neoplasms - etiology
Neoplasms - therapy
Organoids
Tumor Cells, Cultured
Specialty
Cell Biology
Medical Oncology
Abstract
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell-cell, cell-ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Contents
Techniques to Produce and Culture Lung Tumor Organoids -- Tissue Organoids: Liver -- Mammary Gland Organoids -- Biofabrication Technologies for Developing In Vitro Tumor Models -- Three Dimensional In Vitro Tumor Platforms for Cancer Discovery -- Tissue-Engineered Models for Studies of Bone Metastasis -- Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis -- Microfluidics in Cell and Tissue Studies -- Stiffness-tuned Matrices for Tumor Cell Studies -- Mathematical Modeling of Tumor Organoids: Toward Personalized Medicine.
Format
e-Book
Location
Online
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7 records – page 1 of 1.