Management of castration resistant prostate cancer
https://libcat.nshealth.ca/en/permalink/provcat34052
Fred Saad, Mario A. Eisenberger, editors.
--New York:
Humana Press
, c2014.
- Available Online
- View e-Book
- Location
- Online
This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC bas…
- Available Online
- View e-Book
- Other Authors
- Saad, Fred
- Eisenberger, Mario A.
- Responsibility
- Fred Saad, Mario A. Eisenberger, editors
- Place of Publication
- New York
- Publisher
- Humana Press
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xvi, 337 pages)
- Series Title
- Current clinical urology
- ISBN
- 9781493911769 (electronic bk.)
- 9781493911752
- Subjects (MeSH)
- Drug Therapy, Combination
- Molecular Targeted Therapy
- Prostatic Neoplasms, Castration-Resistant - metabolism
- Prostatic Neoplasms, Castration-Resistant - therapy
- Receptors, Androgen - therapeutic use
- Subjects (LCSH)
- Prostate - Cancer - Treatment
- Oncology
- Interventional radiology
- Abstract
- This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence-based medicine.
- Contents
- Part I. Castrate-Resistant Prostate Cancer: Clinical and Biological Considerations -- 1. Introduction—Castration Resistant Prostate Cancer: A Rapidly Expanding Clinical State and a Model for New Therapeutic Opportunities -- 2. Evolution of Clinical States and the Castration Resistant Clinical Paradigm -- 3. Molecular Mechanisms of Prostate Cancer Progression After Castration -- 4. New Imaging Modalities -- Part II. Treatment: The Androgen Receptor Signaling Axis Biology and Therapeutic Opportunities, Systemic Chemotherapy, Immunotherapy, Bone Targeted Approaches and Radiopharmaceuticals -- 5. Androgen Receptor Biology in Castration Resistant Prostate Cancer -- 6. The Androgen Receptor as a Therapeutic Target for Castration-Resistant Prostate Cancer -- 7. Approaches Targeting Androgen Synthesis (CYP 17 Inhibitors) -- 8. Cytotoxic Chemotherapy (Taxanes and Taxane Combinations) -- 9. The Emerging Role of Immunotherapy in Castrate- Resistant Prostate Cancer -- 10. Bone-Targeted Therapy: Rationale and Current Status -- 11. Radium-223 and Other Radiopharmaceuticals in Prostate Cancer -- Part III. New Drug Development: Clinical Trials Design in CRPC -- 12. Introduction -- 13. Phase I–II Targeted Treatments -- 14. Defining Clinical Endpoints in Castration-Resistant Prostate Cancer -- Part IV. New Drug Development: Specific Targets -- 15. Angiogenesis Inhibition in Castration-Resistant Prostate Cancer -- 16. Co-targeting Adaptive Survival Pathways -- 17. Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer -- 18. PARP Inhibitors -- 19. Targeting C-Met/VEGF in Castration Resistant Prostate Cancer -- 20. Epigenetics in Castration Resistant Prostate Cancer -- 21. Undifferentiated Prostate Cancer and the Neuroendocrine Phenotype -- Part V. Clinical Management Aspects -- 22. Strategies Addressing Quality of Life: Management of Patient-Reported Outcomes and Symptoms -- 23. Evidence-Based Therapeutic Approaches for mCRPC Patients: Rational Sequence of Standard Treatment Options and Design for Future Drug Development.
- Format
- e-Book
- Location
- Online
Management of prostate cancer
https://libcat.nshealth.ca/en/permalink/provcat32441
Eric A. Klein, J. Stephen Jones, editors.
(3rd ed.)
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and co…
- Available Online
- View e-Book
- Other Authors
- Klein, Eric A
- Jones, J. Stephen
- Responsibility
- Eric A. Klein, J. Stephen Jones, editors
- Edition
- 3rd ed.
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xi, 428 p. : 37 ill., 11 ill. in color)
- Series Title
- Current clinical urology
- ISBN
- 9781607612599
- Subjects (MeSH)
- Prostatic Neoplasms - diagnosis
- Prostatic Neoplasms - therapy
- Abstract
- The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and comparative treatment outcomes for surgery; and new chapters on risk factors, new markers, nomograms, and focal therapy. This volume also features overviews of new and emerging drugs and treatment paradigms for castrate resistant disease, advances that promise to extend life and perhaps even cure a subset of men with metastatic disease. With its comprehensive illustrations and contributions from renowned experts in the field, Management of Prostate Cancer, 3rd Edition is an invaluable resource for practitioners in the treatment of prostate cancer.
- Contents
- Epidemiology and Risk Factors -- Twenty years and counting: is PSA still useful in 2010? -- Prostate Cancer Screening: A Review of the Evidence with Clinical Practice Implications -- Beyond PSA: Promising New Markers for Prostate Cancer -- Hereditary Prostate Cancer and Genetic Risk -- Prostate Inflammation and Prostate Cancer -- Molecular Progression of Prostate Cancer: Androgens and Estrogens -- The Role of Obesity and Diet in Prostate Cancer -- Prostate Cancer Risk Reduction by Chemoprevention -- Current Issues in Pathologic Evaluation -- Optimum Prostate Biopsy: Technique and Strategies -- The Utility of Nomograms in Routine Clinical Practice -- Active Surveillance Comes of Age -- Focal Therapy: Prostate Hemiablation as the First Historical Treatment Model for Focal Therapy of Early Stage Prostate Cancer -- Contemporary External Beam Radiotherapy -- Surgery, Brachytherapy, or External Beam Radiation for Low and Intermediate-Risk Disease? -- The Role for Radical Prostatectomy in Advanced Prostate Cancer -- Radiation Therapy in the Management of Locally Advanced Prostate Cancer -- Clinical Implications of Measuring Quality-of-Life in Early Stage Prostate Cancer -- Treatment Modalities of Post-Prostatectomy Incontinence: A Historical Perspective As Well As Current Therapy Options -- Management of Biochemical Recurrence After Localized Treatment for Prostate Cancer -- Management of Newly Diagnosed Metastatic Disease -- Pitfalls of Androgen Deprivation Therapy -- Current Management of Castration-resistant Prostate Cancer (CRPC) -- Radiopharmaceuticals and Bone Metastasis -- Index.
- Format
- e-Book
- Location
- Online
Androgen deficiency and testosterone replacement : current controversies and strategies
https://libcat.nshealth.ca/en/permalink/provcat32455
Wayne J.G. Hellstrom, editor.
--New York, NY:
Humana Press
, c2013.
- Available Online
- View e-Book
- Location
- Online
Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of …
- Available Online
- View e-Book
- Other Authors
- Hellstrom, Wayne J.G
- Responsibility
- Wayne J.G. Hellstrom, editor
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2013
- Physical Description
- 1 online resource (x, 154 p. : 17 ill., 10 ill. in color)
- Series Title
- Current clinical urology
- ISBN
- 9781627031790
- Subjects (LCSH)
- Endocrinology
- Urology
- Abstract
- Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of the book will serve as a source of basic information about testosterone replacement and as a source of reasoned analysis of the controversies surrounding testosterone replacement in the aging male. Physicians and physician extenders will be able to apply evidence management principles to the evaluation and treatment of men with testosterone deficiency; supported by the most recent practice guidelines available. The authors represent a select group of physicians with expertise in androgen deficiency and replacement. Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies will be of great value to all physicians and physician extenders who deliver health care to men of all ages.
- Contents
- The Institute of Medicine White Paper on Testosterone: Current Perspective -- The Laboratory Diagnosis of Testosterone Deficiency -- The Clinical Diagnosis of Androgen Deficiency -- The Use of Patient Reported Outcome Questionnaires in the Diagnosis of Androgen Deficiency -- Testosterone, and its Association with Metabolic and Cardiovascular Disease -- The Role of Androgens in Prostate Cancer -- Androgen Deficiency in the Adolescent Male -- Effects of Androgen Deficiency and Replacement on Male Fertility -- HIV and Testosterone in Men -- Treatment Options for Testosterone Replacement Therapy -- Alternate Therapies for Testosterone Replacement.
- Format
- e-Book
- Location
- Online
Urological Men's Health : A Guide for Urologists and Primary Care Physicians
https://libcat.nshealth.ca/en/permalink/provcat31025
editor, Daniel A. Shoskes.
--New York, NY:
Humana Press
, c2012.
- Available Online
- View e-Book
- Location
- Online
Urological Men's Health: A Guide for Urologists and Primary Care Physicians covers the major urologic conditions that have an impact on the health and well being of the adult male. It opens with an overview of general men's preventative health, as practiced by a world leading Executive Health center. The volume covers the major genitourinary malignancies and addresses the latest controversies in screening and treatment selection. This is followed by coverage of the conditions that don't shorten…
- Available Online
- View e-Book
- Author
- Shoskes, Daniel A
- Responsibility
- editor, Daniel A. Shoskes
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (x, 215 p. : 38 ill., 25 ill. in color)
- Series Title
- Current clinical urology
- ISBN
- 9781617799006
- Subjects (MeSH)
- Male Urogenital Diseases
- Men's Health
- Andrology
- Subjects (LCSH)
- Family medicine
- Internal medicine
- Urology
- Abstract
- Urological Men's Health: A Guide for Urologists and Primary Care Physicians covers the major urologic conditions that have an impact on the health and well being of the adult male. It opens with an overview of general men's preventative health, as practiced by a world leading Executive Health center. The volume covers the major genitourinary malignancies and addresses the latest controversies in screening and treatment selection. This is followed by coverage of the conditions that don't shorten life but have major impact on quality of life and health care expenditure: BPH, urinary incontinence, infertility, urethral strictures, erectile dysfunction, urinary tract infections and chronic pelvic pain. Also included are chapters on herbal and complementary therapy, psychological and spousal support in urologic illness and the links between genitourinary disease and general vascular endothelial dysfunction.Urological Men's Health: A Guide for Urologists and Primary Care Physicians will be of great value to Urologists, Internists, General Practitioners and the residents and fellows who train within these specialties.
- Contents
- 1. Evidence Based and Age Appropriate Preventative Health Evaluations in Men -- 2. Clinical Testing Of Endothelial Function In Erectile Dysfunction -- 3. Controversies and Opportunities for PSA Screening -- 4. A Phenotypic Approach to the Evaluation and Treatment of Men with Chronic Pelvic Pain Syndrome -- 5. Recurrent Urinary Tract Infection in Men -- 6. Evaluation and Medical Management of BPH and LUTS in Men -- 7. The Surgical Treatment of Benign Prostatic Hyperplasia (BPH) -- 8. Rational Herbal and Complementary Interventions for Prevention and Treatment of Urological Disorders in Men -- 9. Androgen Decline in the Aging Male: Making Sense of the "Male Menopause" -- 10. Evaluation and Treatment of Peyronie's Disease -- 11. Primary Care Evaluation and Treatment of Erectile Dysfunction -- 12. Surgical Treatment for Erectile Dysfunction -- 13. Managing Overactive Bladder and Urinary Incontinence in the Male -- 14. Treatment of Localized Prostate Cancer -- 15. Management of Urethral Strictures in Men -- 16. Medical and Surgical Interventions in Male Fertility -- 17. Evaluation and Therapy of Chronic Scrotal Content Pan and Epididymitis -- 18. Psychosocial Factors in Painful Urogenital Conditions in Men.
- Format
- e-Book
- Location
- Online
