Androgen deficiency and testosterone replacement : current controversies and strategies
https://libcat.nshealth.ca/en/permalink/provcat32455
Wayne J.G. Hellstrom, editor.
--New York, NY:
Humana Press
, c2013.
- Available Online
- View e-Book
- Location
- Online
Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of …
- Available Online
- View e-Book
- Other Authors
- Hellstrom, Wayne J.G
- Responsibility
- Wayne J.G. Hellstrom, editor
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2013
- Physical Description
- 1 online resource (x, 154 p. : 17 ill., 10 ill. in color)
- Series Title
- Current clinical urology
- ISBN
- 9781627031790
- Subjects (LCSH)
- EndocrinologyÂ
- Urology
- Abstract
- Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of the book will serve as a source of basic information about testosterone replacement and as a source of reasoned analysis of the controversies surrounding testosterone replacement in the aging male. Physicians and physician extenders will be able to apply evidence management principles to the evaluation and treatment of men with testosterone deficiency; supported by the most recent practice guidelines available. The authors represent a select group of physicians with expertise in androgen deficiency and replacement. Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies will be of great value to all physicians and physician extenders who deliver health care to men of all ages.
- Contents
- The Institute of Medicine White Paper on Testosterone: Current Perspective -- The Laboratory Diagnosis of Testosterone Deficiency -- The Clinical Diagnosis of Androgen Deficiency -- The Use of Patient Reported Outcome Questionnaires in the Diagnosis of Androgen Deficiency -- Testosterone, and its Association with Metabolic and Cardiovascular Disease -- The Role of Androgens in Prostate Cancer -- Androgen Deficiency in the Adolescent Male -- Effects of Androgen Deficiency and Replacement on Male Fertility -- HIV and Testosterone in Men -- Treatment Options for Testosterone Replacement Therapy -- Alternate Therapies for Testosterone Replacement.
- Format
- e-Book
- Location
- Online
Androgen Excess Disorders in Women : Polycystic Ovary Syndrome and Other Disorders
https://libcat.nshealth.ca/en/permalink/provcat29185
edited by Ricardo Azziz, John E. Nestler, Didier Dewailly.
(2nd ed.)
--Totowa, NJ:
Humana Press
, c2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Azziz, Ricardo
- Other Authors
- Nestler, John E
- Dewailly, Didier
- Responsibility
- edited by Ricardo Azziz, John E. Nestler, Didier Dewailly
- Edition
- 2nd ed.
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2007
- Series Title
- Contemporary endocrinology (Totowa, N.J.)
- ISBN
- 9781597451796
- Subjects (LCSH)
- EndocrinologyÂ
- Gynecology
- Format
- e-Book
- Location
- Online
Management of castration resistant prostate cancer
https://libcat.nshealth.ca/en/permalink/provcat34052
Fred Saad, Mario A. Eisenberger, editors.
--New York:
Humana Press
, c2014.
- Available Online
- View e-Book
- Location
- Online
This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC bas…
- Available Online
- View e-Book
- Other Authors
- Saad, Fred
- Eisenberger, Mario A.
- Responsibility
- Fred Saad, Mario A. Eisenberger, editors
- Place of Publication
- New York
- Publisher
- Humana Press
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xvi, 337 pages)
- Series Title
- Current clinical urology
- ISBN
- 9781493911769 (electronic bk.)
- 9781493911752
- Subjects (MeSH)
- Drug Therapy, Combination
- Molecular Targeted Therapy
- Prostatic Neoplasms, Castration-Resistant - metabolism
- Prostatic Neoplasms, Castration-Resistant - therapy
- Receptors, Androgen - therapeutic use
- Subjects (LCSH)
- Prostate - Cancer - Treatment
- Oncology
- Interventional radiology
- Abstract
- This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in-depth review of proven therapeutic options, including bone-targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigation are also reviewed. The text provides up-to-date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence-based medicine.
- Contents
- Part I. Castrate-Resistant Prostate Cancer: Clinical and Biological Considerations -- 1. Introduction—Castration Resistant Prostate Cancer: A Rapidly Expanding Clinical State and a Model for New Therapeutic Opportunities -- 2. Evolution of Clinical States and the Castration Resistant Clinical Paradigm -- 3. Molecular Mechanisms of Prostate Cancer Progression After Castration -- 4. New Imaging Modalities -- Part II. Treatment: The Androgen Receptor Signaling Axis Biology and Therapeutic Opportunities, Systemic Chemotherapy, Immunotherapy, Bone Targeted Approaches and Radiopharmaceuticals -- 5. Androgen Receptor Biology in Castration Resistant Prostate Cancer -- 6. The Androgen Receptor as a Therapeutic Target for Castration-Resistant Prostate Cancer -- 7. Approaches Targeting Androgen Synthesis (CYP 17 Inhibitors) -- 8. Cytotoxic Chemotherapy (Taxanes and Taxane Combinations) -- 9. The Emerging Role of Immunotherapy in Castrate- Resistant Prostate Cancer -- 10. Bone-Targeted Therapy: Rationale and Current Status -- 11. Radium-223 and Other Radiopharmaceuticals in Prostate Cancer -- Part III. New Drug Development: Clinical Trials Design in CRPC -- 12. Introduction -- 13. Phase I–II Targeted Treatments -- 14. Defining Clinical Endpoints in Castration-Resistant Prostate Cancer -- Part IV. New Drug Development: Specific Targets -- 15. Angiogenesis Inhibition in Castration-Resistant Prostate Cancer -- 16. Co-targeting Adaptive Survival Pathways -- 17. Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer -- 18. PARP Inhibitors -- 19. Targeting C-Met/VEGF in Castration Resistant Prostate Cancer -- 20. Epigenetics in Castration Resistant Prostate Cancer -- 21. Undifferentiated Prostate Cancer and the Neuroendocrine Phenotype -- Part V. Clinical Management Aspects -- 22. Strategies Addressing Quality of Life: Management of Patient-Reported Outcomes and Symptoms -- 23. Evidence-Based Therapeutic Approaches for mCRPC Patients: Rational Sequence of Standard Treatment Options and Design for Future Drug Development.
- Format
- e-Book
- Location
- Online
Management of advanced prostate cancer
https://libcat.nshealth.ca/en/permalink/provcat43360
edited by Choung Soo Kim.
--Singapore:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer with the aim of providing the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy.
- Available Online
- View e-Book
- Other Authors
- Kim, Choung Soo
- Responsibility
- edited by Choung Soo Kim
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (ix, 201 p.) : 11 illus., 8 illus. in color
- ISBN
- 9789811069437
- 9789811069420 (print ed.)
- 9789811069444 (print ed.)
- 9789811329333 (print ed.)
- Subjects (MeSH)
- Prostatic Neoplasms - therapy
- Specialty
- Medical Oncology
- Urology
- Abstract
- This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer with the aim of providing the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy.
- Contents
- Section 1. Surgery for advanced prostate cancer -- Section 2 Radiotherapy for advanced prostate cancer -- Section 3. Androgen deprivation therapy for advanced prostate cancer -- Section 4. Chemotherapy and immunotherapy and palliative care for advanced prostate cancer.
- Format
- e-Book
- Location
- Online
Managing Metastatic Prostate Cancer In Your Urological Oncology Practice
https://libcat.nshealth.ca/en/permalink/provcat40190
K.C Balaji, editor.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation strategies, in depth analysis of combination and sequencing strategies, outlines upcoming novel drugs and trends in research, and stresses the role of palliative care in this incurable disease. Managing Metastatic Prostate Cancer in Your Urological Oncology Practic…
- Available Online
- View e-Book
- Other Authors
- Balaji, K.C
- Responsibility
- K.C Balaji, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiii, 280 p. : 35 illus., 31 illus. in color)
- ISBN
- 9783319313412
- 9783319313399 (print ed.)
- Abstract
- This text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation strategies, in depth analysis of combination and sequencing strategies, outlines upcoming novel drugs and trends in research, and stresses the role of palliative care in this incurable disease. Managing Metastatic Prostate Cancer in Your Urological Oncology Practice will serve as a very useful resource for physicians and researchers dealing with, and interested in prostate cancer. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and will include the most up to date scientific and clinical information.
- Contents
- Introduction -- Pathophysiology of Castration-Resistant Prostate Cancer -- Androgen Receptor Signaling in Castration Resistant Prostate Cancer -- Non-Androgen Signaling Pathways in Castration-Resistant Prostate Cancer -- Predictive Models in Castration Resistant Prostate Cancer -- Docetaxel in Advanced and Castration Resistant Prostate Cancer -- Combination Treatment Strategies with Docetaxel in Patients with Metastatic Prostate -- Cancer Vaccines in Castration Resistant Prostate Cancer: An evolution in design -- Abiraterone for the treatment of mCRPC -- Enzalutamide in Metastatic Castration Resistant Prostate Cancer -- Radium-223 in Metastatic Castrate Resistant Prostate Cancer -- Cabazitaxel for the Treatment of Prostate Cancer -- Sequencing Therapies in Metastatic Castration Resistant Prostate Cancer -- Bone Preservation Strategies for Men on Androgen Deprivation Therapy -- Novel Therapies in Castration-Resistant Prostate Cancer.
- Format
- e-Book
- Location
- Online
Male Hypogonadism : Basic, Clinical and Therapeutic Principles
https://libcat.nshealth.ca/en/permalink/provcat41715
Stephen J. Winters, Ilpo T. Huhtaniemi, editors.
(Second edition)
--Cham:
Humana Press
, 2017.
- Available Online
- View e-Book
- Location
- Online
Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction…
- Available Online
- View e-Book
- Other Authors
- Winters, Stephen J
- Huhtaniemi, Ilpo T
- Responsibility
- Stephen J. Winters, Ilpo T. Huhtaniemi, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xiv, 446 pages) : 90 illus., 42 illus. in color
- Series Title
- Contemporary endocrinology
- ISBN
- 9783319532981
- 9783319532967 (print ed.)
- ISSN
- 2523-3785
- 2523-3793 (e)
- Subjects (MeSH)
- Genital Diseases, Male
- Hypogonadism
- Abstract
- Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction, such as Klinefelter syndrome, cryptorchidism, and disorders of the pituitary, as well as reproductive and endocrine consequences of cancer treatment, environmental factors, obesity and aging. Next are chapters that describe the available options for androgen replacement therapy, and the outcomes when men with hypogonadism of various causes are treated with testosterone, as well as a chapter devoted to current approaches to stimulating spermatogenesis in gonadotropin-deficient men. Highly practical and updated with the latest available data, this second edition of Male Hypogonadism: Basic, Clinical and Therapeutic Principles cogently presents a large body of scientific information on male reproductive endocrinology to provide a thorough understanding of the pathophysiology, clinical characteristics, and treatments for disorders that adversely affect testicular function.
- Contents
- 1. Neuroendocrine Control of Human Testicular Function -- 2. The Human Leydig Cell -- 3. Human Spermatogenesis and its Regulation -- 4. Normal and Delayed Puberty -- 5. Congenital Hypogonadotropic Hypogonadism in Males: Clinical Features and Pathophysiology -- 6. Male Hypogonadism Resulting From Mutations in the Genes for the Gonadotropin Subunits and their Receptors -- 7. Hypogonadism in Males with Congenital Adrenal Hyperplasia -- 8. Male Hypogonadism Due to Disorders of the Pituitary and Suprasellar Region -- 9. Klinefelter Syndrome and Other Forms of Primary Testicular Failure -- 10. The Undescended Testis -- 11. Male Hypogonadism and Liver Disease -- 12. Male Hypogonadism Due to Cancer and Cancer Treatments -- 13. Exercise and Male Hypogonadism: Testosterone, the Hypothalamic-Pituitary- Testicular Axis, and Exercise Training -- 14. Environmental Causes of Testicular Dysfunction -- 15. Sex Hormone-binding Globulin and the Metabolic Syndrome -- 16. An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men -- 17. Obesity and Aging in Late-onset Hypogonadism -- 18. Androgen Replacement Therapy in Hypogonadal Men -- 19. Androgen Therapy for Hypogonadism in Men with Chronic Illnesses -- 20. Stimulation of Spermatogenesis in Hypogonadotropic Men.
- Format
- e-Book
- Location
- Online
Endocrinology of the Testis and Male Reproduction
https://libcat.nshealth.ca/en/permalink/provcat44566
edited by Manuela Simoni, Ilpo Huhtaniemi.
--Cham:
Springer
, c2017.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive overview of endocrinology of the male reproductive system, explaining how it works and how, sometimes, it fails to work. World-class specialists present state of the art knowledge on all aspects, including anatomy, physiology, molecular biology, genetics, pathophysiology, clinical manifestations of testicular diseases, endocrine aspects of andrological and sexual diseases, and therapy. Extensive consideration is given to sexual development, testicular function…
- Available Online
- View e-Book
- Other Authors
- Simoni, Manuela
- Huhtaniemi, Ilpo
- Responsibility
- edited by Manuela Simoni, Ilpo Huhtaniemi
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2017
- Physical Description
- 1 online resource
- Series Title
- Springer reference
- Endocrinology
- ISBN
- 9783319294568
- ISSN
- 2510-1927
- Subjects (MeSH)
- Andrology
- Endocrine System
- Infertility, Male
- Reproductive Medicine
- Reproductive Physiological Phenomena
- Testis - physiology
- Specialty
- Endocrinology
- Men's Health
- Reproductive Medicine
- Notes
- "Living reference work."
- Abstract
- This book provides a comprehensive overview of endocrinology of the male reproductive system, explaining how it works and how, sometimes, it fails to work. World-class specialists present state of the art knowledge on all aspects, including anatomy, physiology, molecular biology, genetics, pathophysiology, clinical manifestations of testicular diseases, endocrine aspects of andrological and sexual diseases, and therapy. Extensive consideration is given to sexual development, testicular function, the clinical approach to disorders of male reproduction, male hypogonadism, sexual dysfunction, and male infertility. In addition, sociodemographic, psychological, and ethical aspects of male reproductive disorders are discussed. The book is intended as a major reference for endocrinologists, andrologists, and sexologists, as well as basic and clinical scientists. It is published as part of the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.
- Contents
- Anabolic and Metabolic Effects of Testosterone and Other Androgens: Direct Effects and Role of Testosterone Metabolic Products -- Anamnesis and Physical Examination -- Androgen Receptor -- Androgen Resistance -- Assisted Reproduction for Male Infertility -- Classification and Epidemiology of Hypogonadism -- Clinical Manifestation and Diagnosis of Androgen Deficiency -- Color-Doppler Ultrasound and New Imaging Techniques in Andrological Examination -- Control of GnRH Secretion -- Cryopreservation of Spermatozoa -- Delayed Puberty -- Effect of Cancer Treatments on Testicular Function -- Endocrinology of the Fetal Testis -- Epididymal Sperm Transport and Fertilization -- Estrogen Deficiency in Men -- Ethical Aspects of Male Reproductive Disorders and their Treatment -- Functional Anatomy and Histology of the Testis -- Genetic Analysis in Male Infertility -- Genetics of Male Infertility -- GnRH Action -- Gonadotrophin Receptors -- Gonadotropins -- Gynecomastia -- Histopathological Evaluation of Testicular Biopsy -- Hormonal Laboratory Examination -- Hormonal Treatment of Male Infertility: Gonadotropins and Beyond -- Hypogonadism in Systemic Diseases -- Infectious and Immunological Aspects of Male Infertility -- Intra-Testicular Sperm Extraction -- Late-Onset Hypogonadism -- Male Contraception -- Male Sexual Differentiation -- Nonhormonal Medical Treatment of Male Infertility -- Pre-Testicular, Testicular, and Post-Testicular Causes of Male Infertility -- Primary and Secondary Hypogonadism -- Psychological Aspects of Infertility Among Men -- Sex Determination -- Spermatogenesis -- Testicular Steroidogenesis -- Testis Development and Descent -- The Semen Analysis: The Investigation of the Human Ejaculate -- Therapy with Anti-androgens in Gender Dysphoric Natal Males -- Treatment of Hypogonadism -- Use, Misuse, and Abuse of Androgens -- Varicocele.
- Format
- e-Book
- Location
- Online
Chemotherapy and Immunotherapy in Urologic Oncology : A Guide for the Advanced Practice Provider
https://libcat.nshealth.ca/en/permalink/provcat46364
Edouard J. Trabulsi, Costas D. Lallas, Anne E. Lizardi-Calvaresi, editors.
--Cham:
Springer
, c2021.
- Available Online
- View e-Book
- Access
- NEW Springer 2021
- Location
- Online
This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current…
- Available Online
- View e-Book
- Other Authors
- Trabulsi, Edouard J.
- Lallas, Costas D.
- Lizardi-Calvaresi, Anne E.
- Responsibility
- Edouard J. Trabulsi, Costas D. Lallas, Anne E. Lizardi-Calvaresi, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2021
- Physical Description
- 1 online resource (xiv, 307 p.) : 22 illus., 19 illus. in color
- ISBN
- 9783030520212
- 9783030520205 (Print ed.)
- 9783030520229 (Print ed.)
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Urologic Neoplasms - drug therapy
- Immunotherapy - methods
- Abstract
- This book is designed to familiarize clinical practitioners in systemic therapy options and medical management of urologic malignancies including prostate cancer, bladder and upper tract urothelial carcinoma, and renal cell carcinoma. Organized by organ system, the text highlights new therapies such as novel forms of androgen deprivation, cytotoxic chemotherapy, immune check point and immunomodulatory agents, and targeted therapies. Written by experts in the field, the book also reviews current chemotherapy and immunotherapy regimens for genitourinary malignancies and discusses indications, outcomes, and toxicities, as well as clinical trial concepts. Each of the book’s chapters offers a bulleted box of clinical pearls on the particular role of the APP. Chemotherapy and Immunotherapy in Urologic Oncology: A Guide for the Advanced Practice Provider is a resource for urologists, uro-radiologists, medical clinicians and family practitioners alike, familiarizing its audiences with systemic therapy regimens for urologic malignancies, as well as their expected outcomes and side effects. .
- Contents
- Introduction: Integration of APP into Urologic Oncology Practice -- Part I. Prostate Cancer -- Overview and Active Surveillance of Prostate Cancer -- Monitoring and Managing Men Following Initial Treatment of Prostate Cancer -- Radical Prostatectomy and Survivorship after Radical Prostatectomy -- Multimodal Treatment Plans in Prostate Cancer -- Radiotherapy for Prostate Cancer -- Androgen Deprivation Treatment -- Second Generation Androgen Targeted Agents -- Chemotherapy and prostate cancer -- Radiopharmaceuticals for Prostate Cancer -- Immunotherapy and Novel Agents on the Horizon for the Treatment of Prostate Cancer -- Part II. Bladder Cancer -- Bladder Cancer: Overview, Epidemiology, Initial Presentation and Diagnosis -- Intravesical Therapy for Non Muscle Invasive Urothelial Carcinoma -- Bladder Cancer: Muscle Invasive Disease, Neoadjuvant Chemotherapy, and Radical Cystectomy -- Chemoradiation Bladder Preservation -- Metastatic Bladder Cancer and the Use of Cisplatin Chemotherapy -- Immunotherapy for Metastatic Urothelial Cancer -- Novel and experimental Strategies in the Treatment of Metastatic Urothelial Carcinoma -- Upper Tract Urothelial Carcinoma -- Part III. Kidney Cancer -- Kidney Cancer and Its Treatment -- Targeted Therapies for Treatment of Metastatic Renal Cell Carcinoma -- Immune Therapies for Metastatic Kidney Cancer -- Novel Therapies for Renal Cell Carcinoma -- Part IV. Other Malignancies -- Testicular Cancer -- Penile Cancer.
- Access
- NEW Springer 2021
- Format
- e-Book
- Location
- Online
Clinical Rounds in Endocrinology. Volume I, Adult Endocrinology
https://libcat.nshealth.ca/en/permalink/provcat39509
Anil Bhansali, Yashpal Gogate.
--New Delhi:
Springer India
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book covers interesting and yet often challenging cases among adult patients in a unique Question-Answer format. Simulating the bed-side case discussions during the ward rounds, one question logically leads to another question thereby generating curiosity and promoting evidence-based medicine. Taking the readers through the entire spectrum starting from etiology and pathophysiology to clinical presentation to management principles, each question addresses one key aspect of the disorder. De…
- Available Online
- View e-Book
- Author
- Bhansali, Anil
- Other Authors
- Gogate, Yashpal
- Responsibility
- Anil Bhansali, Yashpal Gogate
- Place of Publication
- New Delhi
- Publisher
- Springer India
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xvii, 469 p. : 161 illus., 114 illus. in color)
- ISBN
- 9788132223986
- 9788132223979 (print ed.)
- Subjects (MeSH)
- Adult
- Endocrine System Diseases
- Abstract
- This book covers interesting and yet often challenging cases among adult patients in a unique Question-Answer format. Simulating the bed-side case discussions during the ward rounds, one question logically leads to another question thereby generating curiosity and promoting evidence-based medicine. Taking the readers through the entire spectrum starting from etiology and pathophysiology to clinical presentation to management principles, each question addresses one key aspect of the disorder. Described in a very simple and lucid narrative, this book ensures sound conceptual understanding while covering each topic comprehensively. This volume covers important topics such as acromegaly, Cushing syndrome, osteoporosis, hypercalcemia, pheochromocytoma, hyperaldosteronism, thyroid disorders, and diabetes in adult patients. These cases are not only seen by endocrinologists, but are also managed by internists, orthopedic surgeons, obstetricians and gynecologists. Less common disorders such as adrenal disorders and androgen excess have also been covered.
- Contents
- Acromegaly: Clinical Perspectives -- Acromegaly: Diagnosis and Treatment -- Hyperprolactinemia -- Cushing's Syndrome: Clinical Perspectives -- Chapter Cushing's Syndrome: Diagnosis and Treatment -- Disorders of Androgen Excess -- Pheochromocytoma and Paraganglioma -- Disorders of Mineralocorticoid Excess -- Hypothyroidism -- Thyrotoxicosis -- Extra-thyroidal Manifestations of Autoimmune Thyroid Disease -- Thyroid Disorders During Pregnancy -- Disorders of Mineral Homeostasis -- Hyperparathyroidism -- Osteoporosis -- Type 1 Diabetes Mellitus -- Type 2 Diabetes Mellitus -- Diabetes-Related Complications-I -- Diabetes-Related Complications-II -- Diabetes During Pregnancy.
- Format
- e-Book
- Publication Type
- Case Reports
- Location
- Online
Hormone Therapy and Castration Resistance of Prostate Cancer
https://libcat.nshealth.ca/en/permalink/provcat42814
Yoichi Arai, Osamu Ogawa, editors.
--Singapore:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This comprehensive reference expounds the current state of hormone therapy and castration resistance of prostate cancer (PCa). Previously, the incidence of PCa in Asian countries was relatively low, but it has been increasing dramatically in recent years. Although most of the new cases are diagnosed in early stages, a significant proportion of patients receive hormone therapy for metastatic disease or for relapse after local treatment. Thus the situation has gradually changed toward earlier and…
- Available Online
- View e-Book
- Other Authors
- Arai, Yoichi
- Ogawa, Osamu
- Responsibility
- Yoichi Arai, Osamu Ogawa, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (viii, 433 p.) : 65 illus., 34 illus. in color
- ISBN
- 9789811070136
- 9789811070129 (print ed.)
- 9789811070143 (print ed.)
- Subjects (MeSH)
- Antineoplastic Agents, Hormonal - therapeutic use
- Prostatic Neoplasms, Castration-Resistant - drug therapy
- Specialty
- Endocrinology
- Medical Oncology
- Urology
- Abstract
- This comprehensive reference expounds the current state of hormone therapy and castration resistance of prostate cancer (PCa). Previously, the incidence of PCa in Asian countries was relatively low, but it has been increasing dramatically in recent years. Although most of the new cases are diagnosed in early stages, a significant proportion of patients receive hormone therapy for metastatic disease or for relapse after local treatment. Thus the situation has gradually changed toward earlier and longer use of hormone therapy. The malignancy finally forms castration-resistant prostate cancer (CRPC) despite the lack of testicular androgen. With advances in understanding of the molecular basis of hormone dependence and CRPC, many new androgen receptor-targeted agents have emerged. During the last decade, much evidence on hormone therapy has been accumulated in Japan. Interestingly, some of these findings are different from those reported from Western countries, suggesting ethnic variation in the outcome of hormone therapy. In the chapters of this book, expert authors provide exhaustive interpretations of the evidence recently reported from Japan and provide important Asian perspectives on hormone therapy for PCa. This work benefits not only Asian urologists but also their Western counterparts and all physicians and medical personnel who are involved in the treatment of PCa.
- Contents
- 1. Introduction -- 2. Recent trends in hormone therapy for prostate cancer in Japan -- 3. Risk assessment among patients receiving primary ADT -- 4. Patient-derived xenografts for research on hormonal therapy of prostate cancer -- 5. Impact of GnRH antagonist and LHRH agonist on the gonadal axis -- 6. Controversies on complete androgen blockade -- 7. Adrenal androgen in prostate cancer -- 8. Intermittent ADT for prostate cancer -- 9. Pognostic significance of monitoring serum testosterone in primary ADT -- 10. Ethnic variation in clinical outcomes of primary ADT for prostate cancer -- 11. ADT in combination with radical prostatectomy -- 12. ADT in combination with radiation therapy -- 13. ADT as salvage therapy after definitive treatment -- 14. ADT for clinically localised prostate cancer -- 15. Complications of ADT -- 16. Hot flash -- 17. Oseteoporosis and fracture risk -- 18. Metaboplic change -- 19. Bone scan index as a biomarker of bone metastasis -- 20. Genetic polymorphism analysis in predicting prognosis of metastatic prostate cancer -- 21. Local therapy in combination with ADT for metastatic prostate cancer -- 22. Oxidative stress and CRPC -- 23. Alternative antiandrogen therapy for CRPC -- 24. Optimization of sequential AR targeted therapy for CRPC -- 25. Enzalutamide therapy for mCRPC in Japanese men -- 26. Abiraterone acetate therapy for mCRPC in Japanese men -- 27. Role of estramustine phosphate for CRPC -- 28. Steroid therapy for CRPC -- 29. MicroRNA analysis in prostate cancer -- 30. AR splicing variant in prostate cancer -- 31. Detection of CTC in CRPC -- 32. New biomarker for CRPC: Glycobiologic perspective -- 33. Bone-tageted treatment in CRPC management -- 34. Skeletal complications in CRPC patients -- 35. Urological complications in men dying from prostate cancer -- 36. Prediction of optimal docetaxel regimen for patients with mCRPC -- 37. Intermittent chemotherapy with decetaxel for mCRPC -- 38. Chemotherapy with cabazitaxel for ìCRPC in Japanese men -- 39. New tageted approach to CRPC -- 40. Molecular basis of neuroendocrine prostate cancer -- 41. Gene therapy for prostate cancer -- 42. Immune therapy for CRPC -- 43. New approach to CRPC using inactivated virus -- 44. Patient-reported outcome in the management of CRPC.
- Format
- e-Book
- Location
- Online
Testosterone : From Basic to Clinical Aspects
https://libcat.nshealth.ca/en/permalink/provcat41559
Alexandre Hohl, editor.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad overview about testosterone, from its basic features to the most recent evidence of clinical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although n…
- Available Online
- View e-Book
- Other Authors
- Hohl, Alexandre
- Responsibility
- Alexandre Hohl, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xiii, 414 pages) : 48 illus., 29 illus. in color
- ISBN
- 9783319460864
- 9783319460840 (print ed.)
- Subjects (MeSH)
- Men's Health
- Testosterone - physiology
- Abstract
- Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad overview about testosterone, from its basic features to the most recent evidence of clinical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleterious events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men's health in general. Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmacology and physiology) through clinical aspects (related diseases and supplementation therapy).
- Contents
- 1. The History of Testosterone and The Testes: From Antiquity to Modern Times -- 2. Androgen Receptor in Health and Disease -- 3. Physiology of Male Gonadotropic Axis and Disorders of Sex Development -- 4. Utility and Limitations in Measuring Testosterone -- 5. Male Puberty: What Is Normal and Abnormal? -- 6. Hypogonadotropic and Hypergonadotropic Hypogonadism -- 7. Functional Hypogonadism: Diabetes Mellitus, Obesity, Metabolic Syndrome, and Testosterone -- 8. Male Hypogonadism and Aging -- 9. Hypogonadism After Traumatic Brain Injury -- 10. Testosterone Therapy: Oral Androgens -- 11. Testosterone Therapy: Transdermal Androgens -- 12. Testosterone Therapy: Injectable Androgens -- 13. Benefits and Adverses Effects of Testosterone Therapy -- 14. Testosterone and Sexual Function -- 15. Testosterone Therapy and Prostate Cancer -- 16. Testosterone and Cardiovascular Effects -- 17. Testosterone and Women -- 18. Testosterone and Endocrine Disruptors: Influence of Endocrine Disruptors on Male Reproductive Tract.-- 19. Testosterone Misuse and Abuse.
- Format
- e-Book
- Location
- Online
Prostate Cancer : A Comprehensive Perspective
https://libcat.nshealth.ca/en/permalink/provcat32548
Ashutosh Tewari, editor.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Prostate cancer is the commonest male cancer with over 5 million survivors in US alone. Worldwide, the problem is staggering and has attracted significant attention by media, scientists and cancer experts. Significant research, discoveries, innovations and advances in treatment of this cancer have produced voluminous literature which is difficult to synthesize and assimilate by the medical community. Prostate Cancer: A Comprehensive Perspective is a comprehensive and definitive source which nea…
- Available Online
- View e-Book
- Author
- Tewari, Ashutosh
- Responsibility
- Ashutosh Tewari, editor
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xxxi, 1110 p. : 289 ill., 219 ill. in color)
- ISBN
- 9781447128649
- Subjects (MeSH)
- Prostatic Neoplasms
- Abstract
- Prostate cancer is the commonest male cancer with over 5 million survivors in US alone. Worldwide, the problem is staggering and has attracted significant attention by media, scientists and cancer experts. Significant research, discoveries, innovations and advances in treatment of this cancer have produced voluminous literature which is difficult to synthesize and assimilate by the medical community. Prostate Cancer: A Comprehensive Perspective is a comprehensive and definitive source which neatly resolves this problem. It covers relevant literature by leading experts in basic science, molecular biology, epidemiology, cancer prevention, cellular imaging, staging, treatment, targeted therapeutics and innovative technologies. Prostate Cancer: A Comprehensive Perspective, is a valuable and timely resource for urologists and oncologists.
- Contents
- Section 1: Basic Scientific Foundation -- 1. Development, Applied and Surgical Anatomy of the Prostate -- 2. Molecular Biology and Prostate Cancer -- 3. Endocrine Mechanisms, Androgen Receptor and Carcinogenesis, Hormone Escape -- 4. Molecular Mechanisms of Castrate Resistant Prostate Cancer -- 5. Immunologic Aspects of Prostate Cancer -- 6. Stem Cells in Carcinogenesis of the Prostate -- 7. Murine Models of Prostate Cancer -- 8. Prostate Cancer and the Metabolic Syndrome -- 9. Inflammation and Cancer of the Prostate -- 10. HIV and Prostate Cancer -- 11. Prostate Cancer Genetics -- 12. Gene Expression Profiling and Somatic Genome Changes -- 13. The Proteomic Approach to Prostate Cancer -- 14. Epigenetic Changes in Prostate Cancer -- 15. Biomarkers of Potential Therapeutic Value -- 16. Prostate Tissue Banking -- 17. Molecular Imaging in Diagnostics -- 18. Molecular Risk Profiling -- 19. Premalignant Lesions of the Prostate -- 20. The Pathology of Prostatic Carcinoma -- 21. The Pathology of Non-Epithelial Tumors of the Prostate -- 22. Neuroendocrine Prostate Cancer -- Section 2: Epidemiology, Screening, and Chemoprevention -- 23. Epidemiology of Prostate Cancer -- 24. Racial Disparities and the Global Picture -- 25. Natural History of Prostate Cancer -- 26. Population-Based Health Systems as a Foundation for Prostate Cancer Control Research: The Cancer Research Network -- 27. Screening for Prostate Cancer -- 28. Next Generation Screening Tests -- 29. Diet and Prostate Cancer: A Holistic Approach to Management -- 30. Estrogens in Prostate Cancer -- 31. Vitamin D and Prostate Cancer -- 32. The Role of 5a-Reductase Inhibitors (5-ARIs) in Prostate Cancer Chemoprevention -- 33. Other Pharmaceutical Agents in the Chemoprevention of Prostate Cancer -- Section 3: Diagnosis and Staging -- 34. Early-Detection and Patient Risk Stratification in Prostate Cancer -- 35. Tumor Markers -- 36. Prostate Specific Membrane Antigen-Based Diagnostics -- 37. Prostate Specific Membrane Antigen-Based Therapeutics -- 38. Presentation and Symptomatology of Prostate Cancer -- 39. The Role of Ultrasonography -- 40. The Use of Magnetic Resonance Imaging in the Management of Prostate Cancer -- 41. The Role of Functional Magnetic Resonance Imaging Techniques -- 42. Prostate Biopsy -- 43. The Staging of Prostate Cancer -- 44. Nuclear Medicine in Prostate Cancer -- 45. Nanotechnology and Prostate Cancer -- Section 4: Risk Assessment and Decision-Making Strategies for Localized Prostate Cancer -- 46. Disease Risk Stratification -- 47. Nomograms in Prostate Cancer -- 48. Comparative Effectiveness of Treatment Alternatives for Localized Prostate Cancer -- Section 5: Management of Localized Disease -- 49. Radical Treatment for Localized Disease: An Overview of Options and Strategies for Decision Making -- 50. Quality of Life and Management of Localized Disease -- 51. Active Surveillance for Favorable-Risk Prostate Cancer -- 52. Anesthesia for Robotic-Assisted Prostatectomy -- 53. Retropubic Radical Prostatectomy: The Technique -- 54. Retropubic Radical Prostatectomy: The Results -- 55. Radical Perineal Prostatectomy -- 56. Laparoscopic Radical Prostatectomy: The Technique -- 57. Laparoscopic Radical Prostatectomy: The Results -- 58. Robotic Assisted Radical Prostatectomy: The Technique -- 59. Lymph Node Dissection in Prostate Cancer Surgery -- 60. External Beam Radiotherapy for Low Risk Prostate Cancer -- 61. Prostate Brachytherapy: Low Dose Rate -- 62. Prostate Brachytherapy: High Dose Rate -- 63. Intensity Modulated Radiotherapy -- 64. Proton Beam Therapy and Novel Radiotherapeutic Approaches to the Treatment of Prostate Cancer -- 65. Prostate Cryotherapy -- 66. Focal Therapies for Localized Prostate Cancer -- Section 6: Failure and Management of Recurrent, Locally Advanced, and Advanced Disease -- 67. Biochemical Failure in Prostate Cancer -- 68. The Phenomenon of PSA Bounce After Radiation Therapy -- 69. Management of Locally Recurrent Disease -- 70. Management of High Risk/Locally Advanced Disease -- 71. Radiotherapy Plus Hormonal Therapy -- 72. Watchful Waiting in Advanced Prostate Cancer -- 73. Androgen and Androgen Receptor Directed Therapy as Initial Treatment for Prostate Cancer -- 74. Hormone-Based Therapies for Castration Resistant Prostate Cancer -- 75. Toxicity of Androgen Deprivation Therapy in Hormone Sensitive Prostate Cancer -- 76. Chemotherapy and Novel Systemic Approaches in the Treatment of Metastatic Castration Resistant Prostate Cancer -- 77. Immunotherapy -- 78. Bone Health: Prevention of Skeletal Related Events and Palliative Care -- Section 7: Outcomes and Complications After Treatment -- 79. Assessment of Treatment Outcomes Following Prostate Cancer Therapy -- 80. Urinary Incontinence -- 81. Erectile Dysfunction -- 82. Immediate/Early Surgical Complications -- 83. Population-Based Outcomes Following Treatment of Clinically-Localized Prostate Cancer -- 84. Management of Radiation Adverse Effects -- 85. Management of Complications Following Minimally Invasive Prostate Cancer Therapy -- Section 8: Management of Emergencies and Palliative Care -- 86. Prostate Cancer Emergencies -- 87. Management of Bone Metastases -- 88. Pain Relief in Metastatic Cancer -- 89. The Psycho-Social Impact of Prostate Cancer -- 90. Nursing Issues in Prostate Cancer.
- Format
- e-Book
- Location
- Online
Men's Health
https://libcat.nshealth.ca/en/permalink/provcat32356
Peter H.C. Lim, editor.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Men's Health is a concise, didactic compendium that covers three important aspects of male sexual health: Testosterone Deficiency Syndrome; Premature Ejaculation and Sexually Transmitted Infections (STIs). The chapters that deal with Testosterone Deficiency Syndrome cover the epidemiology of the condition in the local context, the science behind the condition, its clinical presentation and treatment choices. The section on Premature Ejaculation advises the health practitioner on how to invest…
- Available Online
- View e-Book
- Other Authors
- Lim, Peter H.C
- Responsibility
- Peter H.C. Lim, editor
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xviii, 204 p. : 46 ill., 41 ill. in color)
- ISBN
- 9781447147664
- Subjects (MeSH)
- Hypogonadism
- Premature Ejaculation
- Sexually Transmitted Diseases
- Men's Health
- Reproductive Health
- Sexual Dysfunction, Physiological
- Subjects (LCSH)
- EndocrinologyÂ
- Infectious diseases
- Reproductive medicine
- Urology
- Abstract
- Men's Health is a concise, didactic compendium that covers three important aspects of male sexual health: Testosterone Deficiency Syndrome; Premature Ejaculation and Sexually Transmitted Infections (STIs). The chapters that deal with Testosterone Deficiency Syndrome cover the epidemiology of the condition in the local context, the science behind the condition, its clinical presentation and treatment choices. The section on Premature Ejaculation advises the health practitioner on how to investigate this condition and describes the various treatment options available to the patient. The chapters on Sexually Transmitted Infections cover special aspects of the diagnosis, prevention and treatment of STIs occurring in Men which are not normally highlighted in the usual texts on STI management. Written by experts in the field, Men's Health is a valuable and timely resource for urologists, andrologists, endocrinologists as well as other health professionals practicing in these areas.
- Contents
- Part I: Hypogonadism -- 1. Epidemiology: Late-Onset Hypogonadism in Singapore -- 2. Pathophysiology of Late-Onset Hypogonadism and Risks and Benefits of Replacement Therapy -- 3. Testosterone Assays and Their Potential Pitfalls -- 4. Diagnosing and Evaluating Androgen Deficiency, Including Andropause -- 5. Testosterone Preparations for Treatment of Hypogonadal Men -- 6. Androgens, Use, Misuse, and Abuse -- 7. Testosterone Therapy, Prostate Safety, and Other Safety Issues -- 8. The Role of Testosterone in the Metabolic Syndrome in Men -- 9. The Testosterone and ED (or Sexual Function) Connection -- 10. Treating Hypogonadism Associated with Erectile Dysfunction -- 11. Traditional Asian Herbs: Potential Use for Late-Onset Hypogonadism? -- 12. Effects of Excessive Androgen Use and Abuse -- 13. Practice Pointers for the Practitioner -- 14. Collection Charts/Questionnaires/Testosterone Calculators/Other Aide-Memoires, etc. for the GP -- Part II:Premature Ejaculation -- 15. Introduction -- 16. Etiology of Premature Ejaculation -- 17. Initial Workup and Use of Assessment Tools -- 18. Initial Management of the Newly Diagnosed PE -- 19. Premature Ejaculation: Simple Behavioral Therapy Steps -- 20. Choice of Pharmacologic Agents -- 21. Premature Ejaculation: Treatment of the Difficult Case and Advanced Counseling Techniques and When to Refer -- 22. Management of the Infertile Couple When the Male Partner Has Ejaculatory Dysfunction -- 23. Delayed/Retarded Ejaculation -- 24. Collection of Bedside Aids for Diagnosis and Tools for Assessment of Treatment to Goal -- 25. Frequently Asked Questions on Dapoxetine (FAQ’S) -- Part III: Sexually Transmitted Infections -- 26. Overview -- 27. HIV/AIDS -- 28. Breaking the News and Counseling -- 29. Prostatitis in Men -- 30. STIs, Depression and Sexual Dysfunction -- 31. Guidelines: Making the Diagnosis and Managing the Partner -- Index .
- Format
- e-Book
- Location
- Online
Precision Molecular Pathology of Prostate Cancer
https://libcat.nshealth.ca/en/permalink/provcat42811
Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the…
- Available Online
- View e-Book
- Other Authors
- Robinson, Brian D.
- Mosquera, Juan Miguel
- Ro, Jae Y.
- Divatia, Mukul
- Responsibility
- Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xiv, 570 p.) : 50 illus., 48 illus. in color
- Series Title
- Molecular pathology library
- ISBN
- 9783319640969
- 9783319640945 (print ed.)
- 9783319640952 (print ed.)
- 9783319877211 (print ed.)
- ISSN
- 1935-987X
- Abstract
- This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.
- Contents
- Part I. General Principles -- 1. Precision Medicine in Prostate Cancer: Approach to the Patient -- 2. Epidemiology and Etiology -- 3. High-Grade Prostatic Intraepithelial Neoplasia -- 4. Pathology of Prostate Cancer -- 5. Genetic Susceptibility -- 6. Racial Differences -- 7. Cancer Stem Cells -- Part II. Molecular Signatures of Primary Prostate Cancer -- 8. Prostate Cancer Risk: Single Nucleotide Polymorphisms (SNPs) -- 9. Copy Number Variation/Chromosomal Aberration -- 10. Gene Fusions -- 11. Gene Expression Analysis -- 12. Next-Generation Sequencing -- 13. Epigenetic Alterations in Primary Prostate Cancer -- 14. Proteomics in Prostate Cancer Research -- 15. Metabolomic-Based Stratification in Prostate Cancer -- 16. Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma -- Part III. Molecular Signatures of Advanced Prostate Cancer -- 17. Metastatic Prostate Cancer -- 18. Castration-Resistant Prostate Cancer -- 19. Neuroendocrine Prostate Cancer -- Part IV. Key Molecular Pathways in Prostate Cancer Development and Progression -- 20. The Role of Androgen Receptor in Prostate Cancer -- 21. PI3K/Akt/mTOR/PTEN and ERK/MAPK Pathways -- 22. The Cell Cycle and Androgen Signaling Interactions in Prostate Cancer -- 23. DNA Damage Repair -- 24. Tyrosine Kinase Receptor Signaling in Prostate Cancer -- 25. Microtubules in Prostate Cancer -- Part V. Precision Medicine Approach: Diagnosis, Treatment, Prognosis -- 26. Prostate Cancer Tissue Diagnosis -- 27. Molecular Imaging of Prostate Cancer: Radiopharmaceuticals for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) -- 28. Prostate Cancer Molecular Prognosis -- 29. Molecular Targeted Therapies of Prostate Cancer -- 30. Overview of Prostate Cancer Molecular Classification.
- Format
- e-Book
- Location
- Online
Clinical urologic endocrinology : principles for men's health
https://libcat.nshealth.ca/en/permalink/provcat32343
Parviz K. Kavoussi, Raymond A. Costabile, Andrea Salonia, editors.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Clinical Urologic Endocrinology: Principles for Men's Health provides an organized, accessible reference on men's endocrinological health. Over 30 million men in the US alone suffer from erectile dysfunction and over 13 million men in the US suffer from hypogonadism (low testosterone). One out of seven couples also suffer from subfertility of which 50-60% have male factor involvement. More and more men are coming forward to seek treatment for such issues, which in the past were considered taboo…
- Available Online
- View e-Book
- Other Authors
- Kavoussi, Parviz K
- Costabile, Raymond A
- Salonia, Andrea
- Responsibility
- Parviz K. Kavoussi, Raymond A. Costabile, Andrea Salonia, editors
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xviii, 143 p. : 15 ill., 9 ill. in color)
- ISBN
- 9781447144052
- Subjects (MeSH)
- Hypogonadism
- Infertility, male
- Testosterone - physiology
- Subjects (LCSH)
- EndocrinologyÂ
- Urology
- Abstract
- Clinical Urologic Endocrinology: Principles for Men's Health provides an organized, accessible reference on men's endocrinological health. Over 30 million men in the US alone suffer from erectile dysfunction and over 13 million men in the US suffer from hypogonadism (low testosterone). One out of seven couples also suffer from subfertility of which 50-60% have male factor involvement. More and more men are coming forward to seek treatment for such issues, which in the past were considered taboo and there is a strong need for a book which provides guidance for practitioners who support men in their reproductive and sexual concerns. This book covers in depth the key issues in male reproductive health in one easy-to-use resource. Clinical Urologic Endocrinology: Principles for Men's Health is a valuable reference for urologists, endocrinologists, internal medicine physicians, family medicine physicians, sex therapists, and allied health professionals providing care for men in the areas of sexual health, fertility, and men's endocrinological health.
- Contents
- Anatomy and Physiology of Androgen Regulation in Men -- Development of the Male Reproductive System -- Epidemiology and Diagnosis of Hypogonadism -- Testosterone and Sexual Function -- Treatment of Hypogonadism in Men -- Hypogonadism and Prostate Cancer: To Treat or Not To Treat -- Testosterone and Male Infertility -- Specific Endocrinopathies and Male Infertility -- Index.
- Format
- e-Book
- Location
- Online
Pediatric Gynecology : An Illustrated Guide for Surgeons
https://libcat.nshealth.ca/en/permalink/provcat45663
Ahmed H. Al-Salem.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This richly-illustrated book is a reader-friendly reference guide on pediatric gynecology covering both congenital and acquired conditions. Discussing a broad range of conditions from ovarian cysts and endometriosis to disorders of sexual development and breast disorders, this book presents the topics in a concise manner using a practical approach. Each chapter is divided into sections that cover all aspects of the topic including radiology, surgery and clinical aspects and the text is accompan…
- Available Online
- View e-Book
- Author
- Al-Salem, Ahmed H.
- Responsibility
- Ahmed H. Al-Salem
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xvii, 478 p.) : 372 illus., 342 illus. in color
- ISBN
- 9783030499846
- 9783030499839 (Print ed.)
- 9783030499853 (Print ed.)
- 9783030499860 (Print ed.)
- Subjects (MeSH)
- Child
- Disorders of Sex Development
- Female Urogenital Diseases
- Specialty
- Gynecology
- Pediatrics
- Abstract
- This richly-illustrated book is a reader-friendly reference guide on pediatric gynecology covering both congenital and acquired conditions. Discussing a broad range of conditions from ovarian cysts and endometriosis to disorders of sexual development and breast disorders, this book presents the topics in a concise manner using a practical approach. Each chapter is divided into sections that cover all aspects of the topic including radiology, surgery and clinical aspects and the text is accompanied by ample images.The book will be of use to general surgeons, pediatricians, pediatric surgeons, pediatric endocrinologists, pediatric urologists, obstetricians and gynaecologists.
- Contents
- 1. Development of the Female Reproductive System -- 2. Delayed Puberty in Girls -- 3. Precocious Puberty -- 4. Breast Disorders in Female Children and Adolescents -- 5. Fused Labia (Labial Adhesions) -- 6. Imperforate Hymen -- 7. Labial and Inter-Labial Masses -- 8. Pediatric Vulvovaginal Disorders and Vulvovaginitis -- 9. Inguinal and Femoral Hernias in Girls -- 10. Persistent Mullerian Duct Syndrome -- 11. Vaginal Atresia, Agenesis and Vaginal Septum -- 12. Cloacal Anomalies -- 13. Menstruation Disorders in Adolescents -- 14. Polycystic Ovarian Syndrome -- 15. Endometriosis in Adolescent Girls -- 16. Amenorrhea in Adolescents -- 17. Ovarian Cysts and Tumors -- 18. Rhabdomyosarcoma of Female Children Genital Tract -- 19. Disorders of Sexual Development -- 20. Congenital Adrenal Hyperplasia (CAH) -- 21. Androgen Insensitivity Syndrome (Testicular Feminization Syndrome) -- 22. Deficient Testosterone Biosynthesis -- 23. Gonadal Dysgenesis -- 24. Ovotestis Disorders of Sexual Development.
- Format
- e-Book
- Location
- Online
Frontiers in Gynecological Endocrinology. Volume 2, From Basic Science to Clinical Application
https://libcat.nshealth.ca/en/permalink/provcat33645
Bart C.J.M. Fauser, Andrea R. Genazzani, editors.
--Cham, Switzerland:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Corporate Author
- International School of Gynecological and Reproductive Endocrinology
- Other Authors
- Fauser, B. C. J. M
- Genazzani, Andrea R
- Responsibility
- Bart C.J.M. Fauser, Andrea R. Genazzani, editors
- Alternate Title
- From basic science to clinical application
- Place of Publication
- Cham, Switzerland
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (vii, 206 pages)
- ISBN
- 9783319096629 (electronic bk.)
- 9783319096612
- Subjects (MeSH)
- Aging
- Endocrine System Diseases
- Menopause - physiology
- Menstruation Disturbances - physiopathology
- Primary Ovarian Insufficiency - therapy
- Reproductive Health
- Women's Health
- Subjects (LCSH)
- Endocrine gynecology
- Contents
- Part I. Adolescent Gynecology -- 1. Disorders of the Menstrual Cycle During Adolescence -- 2. PCOS and Insulin Resistance (IR): From Lifestyle to Insulin Sensitizers -- 3. Polycystic Ovary Syndrome: From Contraception to Hormone Replacement Therapy -- 4. Management of Adolescent Hyperandrogenism -- 5. Prevention of Adolescent Pregnancies -- 6. Transsexualism: Endocrine Aspects -- Part II. Hormonal Contraception -- 7. How to Choose the Right Contraceptive Method for the Right Woman -- 8. Hormonal Contraceptives: Progestogen and Thrombotic Risk -- Part III. Heavy Menstrual Bleeding, Fibroids, Adenomyosis and Endometriosis -- 9. Heavy Menstrual Bleeding: The Daily Challenge for Gynecologist -- 10. Challenges of Laparoscopic Resection of Uterine Fibroids in Infertility -- 11. Effects on Sexual Function of Medical and Surgical Therapy for Endometriosis -- Part IV. Assisted Reproduction: the Endocrine Impact -- 12. In Patients with Only One or Two Oocytes, Is IVF-ET or ICSI Better? -- 13. Supplementation with DHEA in Poor Responder Patients -- 14. Premature Ovarian Failure: Fertility Challenge -- Part V. Metabolic Syndrome -- 15. Endocrine and Metabolic Disorders in Aging Women -- 16. Obesity and Metabolic Syndrome: Impact and Relationship with Menopausal Transition -- Part VI. Menopause -- 17. Cardiovascular Prevention at the Menopausal Transition: Role of Hormonal Therapies -- 18. Menopause and HRT: Doubts and Certainties -- Part VII. Breast Cancer -- 19. Androgen Receptor and Breast Cancer -- 20. Fertility Preservation and Pregnancy After Breast Cancer: When and How? -- 21. Low Malignant Potential Tumors.
- Format
- e-Book
- Location
- Online
Energy Balance and Prostate Cancer
https://libcat.nshealth.ca/en/permalink/provcat43025
Elizabeth A. Platz, Nathan A. Berger, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume provides a comprehensive treatise on the latest studies linking prostate cancer with energy balance, which together constitute a major challenge and opportunity for research scientists and clinicians especially those dealing with the expanding population of older men confronted with obesity and associated comorbidities. This volume should be a valuable resource to physicians, oncologists, urologists, endocrinologists, nurses, nutritionists, dieticians, and exercise therapists dealin…
- Available Online
- View e-Book
- Other Authors
- Platz, Elizabeth A.
- Berger, Nathan A.
- Responsibility
- Elizabeth A. Platz, Nathan A. Berger, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 187 p.) : 11 illus., 10 illus. in color
- Series Vol.
- v. 14
- Series Title
- Energy balance and cancer
- ISBN
- 9783319649405
- 9783319649399 (print ed.)
- 9783319649412 (print ed.)
- 9783319879062 (print ed.)
- ISSN
- 2199-2622
- Subjects (MeSH)
- Energy Metabolism
- Obesity - complications
- Prostatic Neoplasms - etiology
- Prostatic Neoplasms - metabolism
- Risk Factors
- Specialty
- Medical Oncology
- Physiology
- Urology
- Abstract
- This volume provides a comprehensive treatise on the latest studies linking prostate cancer with energy balance, which together constitute a major challenge and opportunity for research scientists and clinicians especially those dealing with the expanding population of older men confronted with obesity and associated comorbidities. This volume should be a valuable resource to physicians, oncologists, urologists, endocrinologists, nurses, nutritionists, dieticians, and exercise therapists dealing with men with energy balance issues and/or questions regarding the linkage between energy balance and cancer. Moreover, this volume should serve as an important resource for cancer researchers especially for scientists studying lifestyle modification and prevention strategies to better understand and disrupt the linkage between obesity and cancer.
- Contents
- 1. Epidemiology, Energy Balance and Prostate Cancer Incidence and Mortality -- 2. Racial/Ethnic Differences in the Association between Energy Balance and Prostate Cancer -- 3. Consequence of Energy Imbalance in Prostate Cancer and Comorbidities -- 4. Adipokines and Prostate Cancer -- 5. Cross-Sectional Epidemiology and Intervention Studies of Mediators of the Energy Imbalance-Prostate Cancer Association -- 6. Impact of Metabolic Factors on Screening, Early Detection, and Management of Prostate Cancer -- 7. Androgen Deprivation Therapy for Prostate Cancer: Effects on Body Composition and Metabolic Health -- 8. The Integration of Exercise and Dietary Lifestyle Interventions into Prostate Cancer Care -- 9. Energy Balance-Based Strategies to Reduce Consequences of Prostate Cancer: How to Communicate with Men.
- Format
- e-Book
- Location
- Online
Management of prostate cancer : a multidisciplinary approach
https://libcat.nshealth.ca/en/permalink/provcat31170
Michel Bolla, Hendrik Poppel, editors.
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent c…
- Available Online
- View e-Book
- Other Authors
- Bolla, Michel
- Poppel, Hendrik
- Responsibility
- Michel Bolla, Hendrik Poppel, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (viii, 334 p. : 61 ill., 51 ill. in color)
- ISBN
- 9783642275975
- Subjects (MeSH)
- Prostatic Neoplasms - diagnosis
- Prostatic Neoplasms - radiotherapy
- Subjects (LCSH)
- Oncology
- Radiotherapy
- Epidemiology
- Abstract
- This book provides an exhaustive review of the current state of the art in the management of prostate cancer, from screening to treatment. A particular feature is the emphasis placed on the value of a multidisciplinary approach. The opening chapters address basic aspects including epidemiology, biology, and chemoprevention. The role of individual and mass screening is carefully appraised, and diagnosis, clinical work-up, and the role of active surveillance are discussed in detail. Subsequent chapters are devoted to each of the therapies that may be employed, including open and robotic laparoscopic radical prostatectomy, the various forms of radiation therapy, high-intensity focused ultrasound, cryotherapy, hormonal therapy, and targeted therapies and vaccination. Up-to-date data from clinical trials are included. In addition, the EAU guidelines are presented and advice is given on the interpretation of results. The authors are all experts in their field, and the editors are members of the EORTC who have coordinated phase III EORTC trials and have worldwide reputations.
- Contents
- Epidemiology of Prostate Cancer in Europe -- Chemoprevention of Prostate Cancer -- Individual and Mass Screening -- Anatomo-Pathology -- Biomarkers for Prostate Cancer -- Diagnosis, Clinical Work Up, TNM Classifi cation, Markers -- Active Surveillance for Favorable Risk Prostate Cancer: Background, Patient Selection, Triggers for Intervention, and Outcomes -- Open Radical Prostatectomy -- Robot-Assisted Radical Prostatectomy -- Permanent Prostate Brachytherapy -- High-Dose-Rate Brachytherapy: Indications, Technique, and Results -- Intensity Modulated Radiotherapy for Prostate Cancer -- Combination of Androgen Deprivation Therapy and Radiation Therapy for Locally Advanced and Localized Prostate Cancer -- Postoperative Irradiation: Immediate or Early Delayed? -- High-Intensity Focused Ultrasound (HIFU) for Prostate Cancer -- Cryotherapy -- Follow-up After Radical Treatments and Relapse -- First-Line Hormonal Manipulation of Prostate Cancer -- Resistance to Chemical Castration: Second-Line Hormonal Treatment -- Targeted Therapies and Vaccination -- How to Interpret Results? -- Management of Prostate Cancer: EAU Guidelines on Screening, Diagnosis and Treatment -- Better Patients’ Perspective -- Index.
- Format
- e-Book
- Location
- Online
Management of Prostate Cancer : A Multidisciplinary Approach
https://libcat.nshealth.ca/en/permalink/provcat41438
Michel Bolla, Hendrik van Poppel, editors.
(Second edition)
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book, now in an extensively revised second edition, provides an exhaustive review of the state of the art in the management of prostate cancer, from screening to treatment, with emphasis on a multidisciplinary approach. The editors are very excited about the outstanding new or updated contributions from the different expert authors. The opening chapters address basic aspects including epidemiology, pathology, biology, genetics, and chemoprevention. The role of individual and mass screening…
- Available Online
- View e-Book
- Other Authors
- Bolla, Michel
- van Poppel, Hendrik
- Responsibility
- Michel Bolla, Hendrik van Poppel, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (viii, 422 pages) : 76 illus., 64 illus. in color
- ISBN
- 9783319427690
- 9783319427683 (print ed.)
- Subjects (MeSH)
- Prostatectomy
- Prostatic Neoplasms - diagnosis
- Prostatic Neoplasms - radiotherapy
- Prostatic Neoplasms - therapy
- Abstract
- This book, now in an extensively revised second edition, provides an exhaustive review of the state of the art in the management of prostate cancer, from screening to treatment, with emphasis on a multidisciplinary approach. The editors are very excited about the outstanding new or updated contributions from the different expert authors. The opening chapters address basic aspects including epidemiology, pathology, biology, genetics, and chemoprevention. The role of individual and mass screening is carefully appraised, and extensive attention is devoted to diagnosis and clinical work-up by means of recently implemented investigations such as multiparametric MRI and choline PET-CT. The use of active surveillance is examined in detail. Subsequent chapters discuss the different therapies that may be employed: open and minimally invasive, including robot-assisted, radical prostatectomy, the various forms of radiation treatment, high-intensity focused ultrasound, cryotherapy, hormonal manipulations, chemotherapy, targeted therapies, and immunotherapy. Up-to-date results from practice-changing phase III randomized clinical trials are included and special insights are provided into the interpretation of results and the patient's perspective.
- Contents
- Epidemiology of prostate cancer in Europe -- Chemoprevention -- Individual and mass screening -- Anatomo-pathology -- Biology -- Genomics -- Radiologic investigations( multiparametric MRI, whole body MRI) -- Nuclear Medecine: follow-up (Choline PET-CT, Radium 223) and treatment of bone metastases -- Diagnosis, clinical work up, TNM classification Markers -- Active surveillance -- Open Radical Prostatectomy -- The robotic laparoscopic radical prostatectomy -- Brachytherapy (Low dose rate) -- Brachytherapy (High dose rate) -- IMRT, hypofractionated irradiation and stereotactic irradiation -- External irradiation + androgen suppression -- Post-operative irradiation: immediate or early delayed?- High Intensity Focused Ultrasound -- Cryotherapy -- Follow-up after radical treatments and relapse -- First line hormonal manipulations -- Upfront chemotherapy at initiation of hormonal treatment for metastatic prostate cancer -- Bone-targeted therapies (Bisphosphonates, denosumab and Radium 223 -- Targeted therapies and vaccination -- How to interprete results -- Prostate EAU guidelines -- Better Patients perspective.
- Format
- e-Book
- Location
- Online
