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Androgen deficiency and testosterone replacement : current controversies and strategies

https://libcat.nshealth.ca/en/permalink/provcat32455
Wayne J.G. Hellstrom, editor. --New York, NY: Humana Press , c2013.
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Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of …
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Other Authors
Hellstrom, Wayne J.G
Responsibility
Wayne J.G. Hellstrom, editor
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2013
Physical Description
1 online resource (x, 154 p. : 17 ill., 10 ill. in color)
Series Title
Current clinical urology
ISBN
9781627031790
Subjects (MeSH)
Androgens - deficiency
Hypogonadism - therapy
Testosterone - therapeutic use
Subjects (LCSH)
Endocrinology 
Urology
Abstract
Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies explores the difficulties around the diagnosis and treatment of androgen deficiency. The text examines the available evidence concerning the diagnosis and treatment of men with low testosterone. It also examines controversies in the identification and management of these men. While the information contained within will be of use to those who specialize in androgen deficiency and sexual medicine, the scope of the book will serve as a source of basic information about testosterone replacement and as a source of reasoned analysis of the controversies surrounding testosterone replacement in the aging male. Physicians and physician extenders will be able to apply evidence management principles to the evaluation and treatment of men with testosterone deficiency; supported by the most recent practice guidelines available. The authors represent a select group of physicians with expertise in androgen deficiency and replacement. Androgen Deficiency and Testosterone Replacement: Current Controversies and Strategies will be of great value to all physicians and physician extenders who deliver health care to men of all ages.
Contents
The Institute of Medicine White Paper on Testosterone: Current Perspective -- The Laboratory Diagnosis of Testosterone Deficiency -- The Clinical Diagnosis of Androgen Deficiency -- The Use of Patient Reported Outcome Questionnaires in the Diagnosis of Androgen Deficiency -- Testosterone, and its Association with Metabolic and Cardiovascular Disease -- The Role of Androgens in Prostate Cancer -- Androgen Deficiency in the Adolescent Male -- Effects of Androgen Deficiency and Replacement on Male Fertility -- HIV and Testosterone in Men -- Treatment Options for Testosterone Replacement Therapy -- Alternate Therapies for Testosterone Replacement.
Format
e-Book
Location
Online
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Clinical urologic endocrinology : principles for men's health

https://libcat.nshealth.ca/en/permalink/provcat32343
Parviz K. Kavoussi, Raymond A. Costabile, Andrea Salonia, editors. --London: Springer , c2013.
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Clinical Urologic Endocrinology: Principles for Men's Health provides an organized, accessible reference on men's endocrinological health. Over 30 million men in the US alone suffer from erectile dysfunction and over 13 million men in the US suffer from hypogonadism (low testosterone). One out of seven couples also suffer from subfertility of which 50-60% have male factor involvement. More and more men are coming forward to seek treatment for such issues, which in the past were considered taboo…
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Other Authors
Kavoussi, Parviz K
Costabile, Raymond A
Salonia, Andrea
Responsibility
Parviz K. Kavoussi, Raymond A. Costabile, Andrea Salonia, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xviii, 143 p. : 15 ill., 9 ill. in color)
ISBN
9781447144052
Subjects (MeSH)
Hypogonadism
Infertility, male
Testosterone - physiology
Subjects (LCSH)
Endocrinology 
Urology
Abstract
Clinical Urologic Endocrinology: Principles for Men's Health provides an organized, accessible reference on men's endocrinological health. Over 30 million men in the US alone suffer from erectile dysfunction and over 13 million men in the US suffer from hypogonadism (low testosterone). One out of seven couples also suffer from subfertility of which 50-60% have male factor involvement. More and more men are coming forward to seek treatment for such issues, which in the past were considered taboo and there is a strong need for a book which provides guidance for practitioners who support men in their reproductive and sexual concerns. This book covers in depth the key issues in male reproductive health in one easy-to-use resource. Clinical Urologic Endocrinology: Principles for Men's Health is a valuable reference for urologists, endocrinologists, internal medicine physicians, family medicine physicians, sex therapists, and allied health professionals providing care for men in the areas of sexual health, fertility, and men's endocrinological health.
Contents
Anatomy and Physiology of Androgen Regulation in Men -- Development of the Male Reproductive System -- Epidemiology and Diagnosis of Hypogonadism -- Testosterone and Sexual Function -- Treatment of Hypogonadism in Men -- Hypogonadism and Prostate Cancer: To Treat or Not To Treat -- Testosterone and Male Infertility -- Specific Endocrinopathies and Male Infertility -- Index.
Format
e-Book
Location
Online
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Energy Balance and Prostate Cancer

https://libcat.nshealth.ca/en/permalink/provcat43025
Elizabeth A. Platz, Nathan A. Berger, editors. --Cham: Springer , c2018.
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This volume provides a comprehensive treatise on the latest studies linking prostate cancer with energy balance, which together constitute a major challenge and opportunity for research scientists and clinicians especially those dealing with the expanding population of older men confronted with obesity and associated comorbidities. This volume should be a valuable resource to physicians, oncologists, urologists, endocrinologists, nurses, nutritionists, dieticians, and exercise therapists dealin…
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Other Authors
Platz, Elizabeth A.
Berger, Nathan A.
Responsibility
Elizabeth A. Platz, Nathan A. Berger, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 187 p.) : 11 illus., 10 illus. in color
Series Vol.
v. 14
Series Title
Energy balance and cancer
ISBN
9783319649405
9783319649399 (print ed.)
9783319649412 (print ed.)
9783319879062 (print ed.)
ISSN
2199-2622
Subjects (MeSH)
Energy Metabolism
Obesity - complications
Prostatic Neoplasms - etiology
Prostatic Neoplasms - metabolism
Risk Factors
Specialty
Medical Oncology
Physiology
Urology
Abstract
This volume provides a comprehensive treatise on the latest studies linking prostate cancer with energy balance, which together constitute a major challenge and opportunity for research scientists and clinicians especially those dealing with the expanding population of older men confronted with obesity and associated comorbidities. This volume should be a valuable resource to physicians, oncologists, urologists, endocrinologists, nurses, nutritionists, dieticians, and exercise therapists dealing with men with energy balance issues and/or questions regarding the linkage between energy balance and cancer. Moreover, this volume should serve as an important resource for cancer researchers especially for scientists studying lifestyle modification and prevention strategies to better understand and disrupt the linkage between obesity and cancer.
Contents
1. Epidemiology, Energy Balance and Prostate Cancer Incidence and Mortality -- 2. Racial/Ethnic Differences in the Association between Energy Balance and Prostate Cancer -- 3. Consequence of Energy Imbalance in Prostate Cancer and Comorbidities -- 4. Adipokines and Prostate Cancer -- 5. Cross-Sectional Epidemiology and Intervention Studies of Mediators of the Energy Imbalance-Prostate Cancer Association -- 6. Impact of Metabolic Factors on Screening, Early Detection, and Management of Prostate Cancer -- 7. Androgen Deprivation Therapy for Prostate Cancer: Effects on Body Composition and Metabolic Health -- 8. The Integration of Exercise and Dietary Lifestyle Interventions into Prostate Cancer Care -- 9. Energy Balance-Based Strategies to Reduce Consequences of Prostate Cancer: How to Communicate with Men.
Format
e-Book
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Online
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Hormone Therapy and Castration Resistance of Prostate Cancer

https://libcat.nshealth.ca/en/permalink/provcat42814
Yoichi Arai, Osamu Ogawa, editors. --Singapore: Springer , c2018.
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This comprehensive reference expounds the current state of hormone therapy and castration resistance of prostate cancer (PCa). Previously, the incidence of PCa in Asian countries was relatively low, but it has been increasing dramatically in recent years. Although most of the new cases are diagnosed in early stages, a significant proportion of patients receive hormone therapy for metastatic disease or for relapse after local treatment. Thus the situation has gradually changed toward earlier and…
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Other Authors
Arai, Yoichi
Ogawa, Osamu
Responsibility
Yoichi Arai, Osamu Ogawa, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 433 p.) : 65 illus., 34 illus. in color
ISBN
9789811070136
9789811070129 (print ed.)
9789811070143 (print ed.)
Subjects (MeSH)
Antineoplastic Agents, Hormonal - therapeutic use
Prostatic Neoplasms, Castration-Resistant - drug therapy
Specialty
Endocrinology
Medical Oncology
Urology
Abstract
This comprehensive reference expounds the current state of hormone therapy and castration resistance of prostate cancer (PCa). Previously, the incidence of PCa in Asian countries was relatively low, but it has been increasing dramatically in recent years. Although most of the new cases are diagnosed in early stages, a significant proportion of patients receive hormone therapy for metastatic disease or for relapse after local treatment. Thus the situation has gradually changed toward earlier and longer use of hormone therapy. The malignancy finally forms castration-resistant prostate cancer (CRPC) despite the lack of testicular androgen. With advances in understanding of the molecular basis of hormone dependence and CRPC, many new androgen receptor-targeted agents have emerged. During the last decade, much evidence on hormone therapy has been accumulated in Japan. Interestingly, some of these findings are different from those reported from Western countries, suggesting ethnic variation in the outcome of hormone therapy. In the chapters of this book, expert authors provide exhaustive interpretations of the evidence recently reported from Japan and provide important Asian perspectives on hormone therapy for PCa. This work benefits not only Asian urologists but also their Western counterparts and all physicians and medical personnel who are involved in the treatment of PCa.
Contents
1. Introduction -- 2. Recent trends in hormone therapy for prostate cancer in Japan -- 3. Risk assessment among patients receiving primary ADT -- 4. Patient-derived xenografts for research on hormonal therapy of prostate cancer -- 5. Impact of GnRH antagonist and LHRH agonist on the gonadal axis -- 6. Controversies on complete androgen blockade -- 7. Adrenal androgen in prostate cancer -- 8. Intermittent ADT for prostate cancer -- 9. Pognostic significance of monitoring serum testosterone in primary ADT -- 10. Ethnic variation in clinical outcomes of primary ADT for prostate cancer -- 11. ADT in combination with radical prostatectomy -- 12. ADT in combination with radiation therapy -- 13. ADT as salvage therapy after definitive treatment -- 14. ADT for clinically localised prostate cancer -- 15. Complications of ADT -- 16. Hot flash -- 17. Oseteoporosis and fracture risk -- 18. Metaboplic change -- 19. Bone scan index as a biomarker of bone metastasis -- 20. Genetic polymorphism analysis in predicting prognosis of metastatic prostate cancer -- 21. Local therapy in combination with ADT for metastatic prostate cancer -- 22. Oxidative stress and CRPC -- 23. Alternative antiandrogen therapy for CRPC -- 24. Optimization of sequential AR targeted therapy for CRPC -- 25. Enzalutamide therapy for mCRPC in Japanese men -- 26. Abiraterone acetate therapy for mCRPC in Japanese men -- 27. Role of estramustine phosphate for CRPC -- 28. Steroid therapy for CRPC -- 29. MicroRNA analysis in prostate cancer -- 30. AR splicing variant in prostate cancer -- 31. Detection of CTC in CRPC -- 32. New biomarker for CRPC: Glycobiologic perspective -- 33. Bone-tageted treatment in CRPC management -- 34. Skeletal complications in CRPC patients -- 35. Urological complications in men dying from prostate cancer -- 36. Prediction of optimal docetaxel regimen for patients with mCRPC -- 37. Intermittent chemotherapy with decetaxel for mCRPC -- 38. Chemotherapy with cabazitaxel for ìCRPC in Japanese men -- 39. New tageted approach to CRPC -- 40. Molecular basis of neuroendocrine prostate cancer -- 41. Gene therapy for prostate cancer -- 42. Immune therapy for CRPC -- 43. New approach to CRPC using inactivated virus -- 44. Patient-reported outcome in the management of CRPC.
Format
e-Book
Location
Online
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Management of advanced prostate cancer

https://libcat.nshealth.ca/en/permalink/provcat43360
edited by Choung Soo Kim. --Singapore: Springer , c2018.
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This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer with the aim of providing the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy.
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Other Authors
Kim, Choung Soo
Responsibility
edited by Choung Soo Kim
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 201 p.) : 11 illus., 8 illus. in color
ISBN
9789811069437
9789811069420 (print ed.)
9789811069444 (print ed.)
9789811329333 (print ed.)
Subjects (MeSH)
Prostatic Neoplasms - therapy
Specialty
Medical Oncology
Urology
Abstract
This textbook summarizes the state of the art in the management of locally advanced and metastatic prostate cancer with the aim of providing the knowledge required for optimal treatment decision making in individual cases. Readers will find comprehensive coverage of the latest developments in surgery, radiotherapy, androgen deprivation therapy (ADT), chemotherapy, and immunotherapy.
Contents
Section 1. Surgery for advanced prostate cancer -- Section 2 Radiotherapy for advanced prostate cancer -- Section 3. Androgen deprivation therapy for advanced prostate cancer -- Section 4. Chemotherapy and immunotherapy and palliative care for advanced prostate cancer.
Format
e-Book
Location
Online
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Management of prostate cancer

https://libcat.nshealth.ca/en/permalink/provcat32441
Eric A. Klein, J. Stephen Jones, editors. (3rd ed.) --New York, NY: Springer , c2013.
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The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and co…
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Other Authors
Klein, Eric A
Jones, J. Stephen
Responsibility
Eric A. Klein, J. Stephen Jones, editors
Edition
3rd ed.
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xi, 428 p. : 37 ill., 11 ill. in color)
Series Title
Current clinical urology
ISBN
9781607612599
Subjects (MeSH)
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - therapy
Subjects (LCSH)
Oncology
Surgery
Urology
Abstract
The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and comparative treatment outcomes for surgery; and new chapters on risk factors, new markers, nomograms, and focal therapy. This volume also features overviews of new and emerging drugs and treatment paradigms for castrate resistant disease, advances that promise to extend life and perhaps even cure a subset of men with metastatic disease. With its comprehensive illustrations and contributions from renowned experts in the field, Management of Prostate Cancer, 3rd Edition is an invaluable resource for practitioners in the treatment of prostate cancer.
Contents
Epidemiology and Risk Factors -- Twenty years and counting: is PSA still useful in 2010? -- Prostate Cancer Screening: A Review of the Evidence with Clinical Practice Implications -- Beyond PSA: Promising New Markers for Prostate Cancer -- Hereditary Prostate Cancer and Genetic Risk -- Prostate Inflammation and Prostate Cancer -- Molecular Progression of Prostate Cancer: Androgens and Estrogens -- The Role of Obesity and Diet in Prostate Cancer -- Prostate Cancer Risk Reduction by Chemoprevention -- Current Issues in Pathologic Evaluation -- Optimum Prostate Biopsy: Technique and Strategies -- The Utility of Nomograms in Routine Clinical Practice -- Active Surveillance Comes of Age -- Focal Therapy: Prostate Hemiablation as the First Historical Treatment Model for Focal Therapy of Early Stage Prostate Cancer -- Contemporary External Beam Radiotherapy -- Surgery, Brachytherapy, or External Beam Radiation for Low and Intermediate-Risk Disease? -- The Role for Radical Prostatectomy in Advanced Prostate Cancer -- Radiation Therapy in the Management of Locally Advanced Prostate Cancer -- Clinical Implications of Measuring Quality-of-Life in Early Stage Prostate Cancer -- Treatment Modalities of Post-Prostatectomy Incontinence: A Historical Perspective As Well As Current Therapy Options -- Management of Biochemical Recurrence After Localized Treatment for Prostate Cancer -- Management of Newly Diagnosed Metastatic Disease -- Pitfalls of Androgen Deprivation Therapy -- Current Management of Castration-resistant Prostate Cancer (CRPC) -- Radiopharmaceuticals and Bone Metastasis -- Index.
Format
e-Book
Location
Online
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Management of Urological Cancers in Older People

https://libcat.nshealth.ca/en/permalink/provcat32293
Jean-Pierre Droz, Riccardo A. Audisio, editors. --London: Springer , c2013.
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The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy. Management of Urological Cancers in Older People focuses on treatment strategies of u…
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Corporate Author
International Society of Geriatric Oncology
Other Authors
Droz, Jean-Pierre
Audisio, Riccardo A
Responsibility
Jean-Pierre Droz, Riccardo A. Audisio, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xiii, 373 p. : 25 ill., 19 ill. in color)
Series Vol.
1
Series Title
Management of cancer in older people
ISBN
9780857299994
Subjects (MeSH)
Prostatic Neoplasms - therapy
Urinary Bladder Neoplasms - therapy
Urologic Neoplasms - therapy
Subjects (LCSH)
Geriatrics
Oncology
Urology
Abstract
The risk of cancer increases with age and the number of older adults seeking treatment is rising dramatically in line with the aging population. The care of older patients differs from that of younger adults because of variation in the biology of the tumor, age-related variation in host physiology, co-morbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy. Management of Urological Cancers in Older People focuses on treatment strategies of urological cancers and provides guidance on the issues specific to older patients, spanning background and epidemiology, special considerations in the care of older people, therapeutics, and psychosocial considerations. This book offers a thorough review of current approaches to treating older urological cancer patients, detailing the special issues and considerations involved. The discipline-spanning coverage outlines best practice and proposes topics for future research. This first volume in the Management of Cancer in Older People series will be of interest to all surgical oncologists, medical oncologists, gerontologists, urologists and other members of the multidisciplinary team involvedá in the care of elderly urological cancer patients.
Contents
1. Background and Epidemiology -- 2. Health Status Evaluation of Elderly Patients with Genito-Urinary Tumours -- 3. Nomograms and the Elderly: Applications in Genitourinary Oncology -- 4. Renal Function in Elderly and in Relationship with Management of Genito-Urinary Tumours -- 5. Prostate Cancer Screening or Early Diagnosis in Senior Adults? -- 6. Androgen Deprivation in Ederly Prostate Cancer Patients: Side Effects and Their Prevention -- 7. Prognostic Factors of Localized Prostate Cancer in Elderly Patients -- 8. Prostatectomy in Elderly Prostate Cancer Patients -- 9. Radiotherapy in Elderly Prostate Cancer Patients -- 10. Selective Minimally Invasive Therapy in Older Patients for Localised Prostate Cancer: A Way to Mitigate Harm and Retain Benefit? -- 11. Active Surveillance and Watchful Waiting in Indolent Elderly Prostate Cancer Patients -- 12. Decision Making in Elderly Localized Prostate Cancer -- 13. Clinical Management of Elderly Patients with Metastatic Prostate Cancer Chemotherapy -- 14. Clinical Management of Elderly Patients' Metastatic Prostate Cancer'Other Treatments and Supportive Care -- 15. New Treatment Developments Applied to Elderly Patients -- 16. Management of Superficial Bladder Cancer in Elderly Patients -- 17 -- Radical Cystectomy in Muscle-Infiltrative Bladder Cancer and Conservative Treatment in Localised Disease -- 18. Chemotherapy for Elderly Patients with Advanced Transitional Cell Carcinoma -- 19. Tailored Treatment for Bladder Cancer in Older Patients -- 20. Surgery or Observation for Small Real Masses in Older Patients? -- 21. Treatment of Metastatic Kidney Cancer in the Elderly -- 22. Carcinoma of the Penis in the Elderly -- 23. Lymphomas of the Testis in Elderly Patients -- 24. Upper Urinary Tract Tumours in Elderly Patients -- 25. Adrenal Tumours in the Elderly -- 26. Retroperitoneal Tumours in the Elderly.
Format
e-Book
Location
Online
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Peter H.C. Lim, editor. --London: Springer , c2013.
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Men's Health is a concise, didactic compendium that covers three important aspects of male sexual health: Testosterone Deficiency Syndrome; Premature Ejaculation and Sexually Transmitted Infections (STIs). The chapters that deal with Testosterone Deficiency Syndrome cover the epidemiology of the condition in the local context, the science behind the condition, its clinical presentation and treatment choices. The section on Premature Ejaculation advises the health practitioner on how to invest…
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Other Authors
Lim, Peter H.C
Responsibility
Peter H.C. Lim, editor
Place of Publication
London
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xviii, 204 p. : 46 ill., 41 ill. in color)
ISBN
9781447147664
Subjects (MeSH)
Hypogonadism
Premature Ejaculation
Sexually Transmitted Diseases
Men's Health
Reproductive Health
Sexual Dysfunction, Physiological
Subjects (LCSH)
Endocrinology 
Infectious diseases
Reproductive medicine
Urology
Abstract
Men's Health is a concise, didactic compendium that covers three important aspects of male sexual health: Testosterone Deficiency Syndrome; Premature Ejaculation and Sexually Transmitted Infections (STIs). The chapters that deal with Testosterone Deficiency Syndrome cover the epidemiology of the condition in the local context, the science behind the condition, its clinical presentation and treatment choices. The section on Premature Ejaculation advises the health practitioner on how to investigate this condition and describes the various treatment options available to the patient. The chapters on Sexually Transmitted Infections cover special aspects of the diagnosis, prevention and treatment of STIs occurring in Men which are not normally highlighted in the usual texts on STI management. Written by experts in the field, Men's Health is a valuable and timely resource for urologists, andrologists, endocrinologists as well as other health professionals practicing in these areas.
Contents
Part I: Hypogonadism -- 1. Epidemiology: Late-Onset Hypogonadism in Singapore -- 2. Pathophysiology of Late-Onset Hypogonadism and Risks and Benefits of Replacement Therapy -- 3. Testosterone Assays and Their Potential Pitfalls -- 4. Diagnosing and Evaluating Androgen Deficiency, Including Andropause -- 5. Testosterone Preparations for Treatment of Hypogonadal Men -- 6. Androgens, Use, Misuse, and Abuse -- 7. Testosterone Therapy, Prostate Safety, and Other Safety Issues -- 8. The Role of Testosterone in the Metabolic Syndrome in Men -- 9. The Testosterone and ED (or Sexual Function) Connection -- 10. Treating Hypogonadism Associated with Erectile Dysfunction -- 11. Traditional Asian Herbs: Potential Use for Late-Onset Hypogonadism? -- 12. Effects of Excessive Androgen Use and Abuse -- 13. Practice Pointers for the Practitioner -- 14. Collection Charts/Questionnaires/Testosterone Calculators/Other Aide-Memoires, etc. for the GP -- Part II:Premature Ejaculation -- 15. Introduction -- 16. Etiology of Premature Ejaculation -- 17. Initial Workup and Use of Assessment Tools -- 18. Initial Management of the Newly Diagnosed PE -- 19. Premature Ejaculation: Simple Behavioral Therapy Steps -- 20. Choice of Pharmacologic Agents -- 21. Premature Ejaculation: Treatment of the Difficult Case and Advanced Counseling Techniques and When to Refer -- 22. Management of the Infertile Couple When the Male Partner Has Ejaculatory Dysfunction -- 23. Delayed/Retarded Ejaculation -- 24. Collection of Bedside Aids for Diagnosis and Tools for Assessment of Treatment to Goal -- 25. Frequently Asked Questions on Dapoxetine (FAQ’S) -- Part III: Sexually Transmitted Infections -- 26. Overview -- 27. HIV/AIDS -- 28. Breaking the News and Counseling -- 29. Prostatitis in Men -- 30. STIs, Depression and Sexual Dysfunction -- 31. Guidelines: Making the Diagnosis and Managing the Partner -- Index .
Format
e-Book
Location
Online
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Precision Molecular Pathology of Prostate Cancer

https://libcat.nshealth.ca/en/permalink/provcat42811
Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, editors. --Cham: Springer , c2018.
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This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the…
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Other Authors
Robinson, Brian D.
Mosquera, Juan Miguel
Ro, Jae Y.
Divatia, Mukul
Responsibility
Brian D. Robinson, Juan Miguel Mosquera, Jae Y. Ro, Mukul Divatia, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiv, 570 p.) : 50 illus., 48 illus. in color
Series Title
Molecular pathology library
ISBN
9783319640969
9783319640945 (print ed.)
9783319640952 (print ed.)
9783319877211 (print ed.)
ISSN
1935-987X
Subjects (MeSH)
Precision Medicine
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Specialty
Medical Oncology
Molecular Medicine
Pathology
Precision Medicine
Urology
Abstract
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.
Contents
Part I. General Principles -- 1. Precision Medicine in Prostate Cancer: Approach to the Patient -- 2. Epidemiology and Etiology -- 3. High-Grade Prostatic Intraepithelial Neoplasia -- 4. Pathology of Prostate Cancer -- 5. Genetic Susceptibility -- 6. Racial Differences -- 7. Cancer Stem Cells -- Part II. Molecular Signatures of Primary Prostate Cancer -- 8. Prostate Cancer Risk: Single Nucleotide Polymorphisms (SNPs) -- 9. Copy Number Variation/Chromosomal Aberration -- 10. Gene Fusions -- 11. Gene Expression Analysis -- 12. Next-Generation Sequencing -- 13. Epigenetic Alterations in Primary Prostate Cancer -- 14. Proteomics in Prostate Cancer Research -- 15. Metabolomic-Based Stratification in Prostate Cancer -- 16. Tumor Microenvironment: Prospects for Diagnosis and Prognosis of Prostate Cancer Based on Changes in Tumor-Adjacent Stroma -- Part III. Molecular Signatures of Advanced Prostate Cancer -- 17. Metastatic Prostate Cancer -- 18. Castration-Resistant Prostate Cancer -- 19. Neuroendocrine Prostate Cancer -- Part IV. Key Molecular Pathways in Prostate Cancer Development and Progression -- 20. The Role of Androgen Receptor in Prostate Cancer -- 21. PI3K/Akt/mTOR/PTEN and ERK/MAPK Pathways -- 22. The Cell Cycle and Androgen Signaling Interactions in Prostate Cancer -- 23. DNA Damage Repair -- 24. Tyrosine Kinase Receptor Signaling in Prostate Cancer -- 25. Microtubules in Prostate Cancer -- Part V. Precision Medicine Approach: Diagnosis, Treatment, Prognosis -- 26. Prostate Cancer Tissue Diagnosis -- 27. Molecular Imaging of Prostate Cancer: Radiopharmaceuticals for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) -- 28. Prostate Cancer Molecular Prognosis -- 29. Molecular Targeted Therapies of Prostate Cancer -- 30. Overview of Prostate Cancer Molecular Classification.
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e-Book
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Online
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Prostate Cancer : A Comprehensive Perspective

https://libcat.nshealth.ca/en/permalink/provcat32548
Ashutosh Tewari, editor. --London: Springer , c2013.
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Prostate cancer is the commonest male cancer with over 5 million survivors in US alone. Worldwide, the problem is staggering and has attracted significant attention by media, scientists and cancer experts. Significant research, discoveries, innovations and advances in treatment of this cancer have produced voluminous literature which is difficult to synthesize and assimilate by the medical community. Prostate Cancer: A Comprehensive Perspective is a comprehensive and definitive source which nea…
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Author
Tewari, Ashutosh
Responsibility
Ashutosh Tewari, editor
Place of Publication
London
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xxxi, 1110 p. : 289 ill., 219 ill. in color)
ISBN
9781447128649
Subjects (MeSH)
Prostatic Neoplasms
Subjects (LCSH)
Oncology
Urology
Abstract
Prostate cancer is the commonest male cancer with over 5 million survivors in US alone. Worldwide, the problem is staggering and has attracted significant attention by media, scientists and cancer experts. Significant research, discoveries, innovations and advances in treatment of this cancer have produced voluminous literature which is difficult to synthesize and assimilate by the medical community. Prostate Cancer: A Comprehensive Perspective is a comprehensive and definitive source which neatly resolves this problem. It covers relevant literature by leading experts in basic science, molecular biology, epidemiology, cancer prevention, cellular imaging, staging, treatment, targeted therapeutics and innovative technologies. Prostate Cancer: A Comprehensive Perspective, is a valuable and timely resource for urologists and oncologists.
Contents
Section 1: Basic Scientific Foundation -- 1. Development, Applied and Surgical Anatomy of the Prostate -- 2. Molecular Biology and Prostate Cancer -- 3. Endocrine Mechanisms, Androgen Receptor and Carcinogenesis, Hormone Escape -- 4. Molecular Mechanisms of Castrate Resistant Prostate Cancer -- 5. Immunologic Aspects of Prostate Cancer -- 6. Stem Cells in Carcinogenesis of the Prostate -- 7. Murine Models of Prostate Cancer -- 8. Prostate Cancer and the Metabolic Syndrome -- 9. Inflammation and Cancer of the Prostate -- 10. HIV and Prostate Cancer -- 11. Prostate Cancer Genetics -- 12. Gene Expression Profiling and Somatic Genome Changes -- 13. The Proteomic Approach to Prostate Cancer -- 14. Epigenetic Changes in Prostate Cancer -- 15. Biomarkers of Potential Therapeutic Value -- 16. Prostate Tissue Banking -- 17. Molecular Imaging in Diagnostics -- 18. Molecular Risk Profiling -- 19. Premalignant Lesions of the Prostate -- 20. The Pathology of Prostatic Carcinoma -- 21. The Pathology of Non-Epithelial Tumors of the Prostate -- 22. Neuroendocrine Prostate Cancer -- Section 2: Epidemiology, Screening, and Chemoprevention -- 23. Epidemiology of Prostate Cancer -- 24. Racial Disparities and the Global Picture -- 25. Natural History of Prostate Cancer -- 26. Population-Based Health Systems as a Foundation for Prostate Cancer Control Research: The Cancer Research Network -- 27. Screening for Prostate Cancer -- 28. Next Generation Screening Tests -- 29. Diet and Prostate Cancer: A Holistic Approach to Management -- 30. Estrogens in Prostate Cancer -- 31. Vitamin D and Prostate Cancer -- 32. The Role of 5a-Reductase Inhibitors (5-ARIs) in Prostate Cancer Chemoprevention -- 33. Other Pharmaceutical Agents in the Chemoprevention of Prostate Cancer -- Section 3: Diagnosis and Staging -- 34. Early-Detection and Patient Risk Stratification in Prostate Cancer -- 35. Tumor Markers -- 36. Prostate Specific Membrane Antigen-Based Diagnostics -- 37. Prostate Specific Membrane Antigen-Based Therapeutics -- 38. Presentation and Symptomatology of Prostate Cancer -- 39. The Role of Ultrasonography -- 40. The Use of Magnetic Resonance Imaging in the Management of Prostate Cancer -- 41. The Role of Functional Magnetic Resonance Imaging Techniques -- 42. Prostate Biopsy -- 43. The Staging of Prostate Cancer -- 44. Nuclear Medicine in Prostate Cancer -- 45. Nanotechnology and Prostate Cancer -- Section 4: Risk Assessment and Decision-Making Strategies for Localized Prostate Cancer -- 46. Disease Risk Stratification -- 47. Nomograms in Prostate Cancer -- 48. Comparative Effectiveness of Treatment Alternatives for Localized Prostate Cancer -- Section 5: Management of Localized Disease -- 49. Radical Treatment for Localized Disease: An Overview of Options and Strategies for Decision Making -- 50. Quality of Life and Management of Localized Disease -- 51. Active Surveillance for Favorable-Risk Prostate Cancer -- 52. Anesthesia for Robotic-Assisted Prostatectomy -- 53. Retropubic Radical Prostatectomy: The Technique -- 54. Retropubic Radical Prostatectomy: The Results -- 55. Radical Perineal Prostatectomy -- 56. Laparoscopic Radical Prostatectomy: The Technique -- 57. Laparoscopic Radical Prostatectomy: The Results -- 58. Robotic Assisted Radical Prostatectomy: The Technique -- 59. Lymph Node Dissection in Prostate Cancer Surgery -- 60. External Beam Radiotherapy for Low Risk Prostate Cancer -- 61. Prostate Brachytherapy: Low Dose Rate -- 62. Prostate Brachytherapy: High Dose Rate -- 63. Intensity Modulated Radiotherapy -- 64. Proton Beam Therapy and Novel Radiotherapeutic Approaches to the Treatment of Prostate Cancer -- 65. Prostate Cryotherapy -- 66. Focal Therapies for Localized Prostate Cancer -- Section 6: Failure and Management of Recurrent, Locally Advanced, and Advanced Disease -- 67. Biochemical Failure in Prostate Cancer -- 68. The Phenomenon of PSA Bounce After Radiation Therapy -- 69. Management of Locally Recurrent Disease -- 70. Management of High Risk/Locally Advanced Disease -- 71. Radiotherapy Plus Hormonal Therapy -- 72. Watchful Waiting in Advanced Prostate Cancer -- 73. Androgen and Androgen Receptor Directed Therapy as Initial Treatment for Prostate Cancer -- 74. Hormone-Based Therapies for Castration Resistant Prostate Cancer -- 75. Toxicity of Androgen Deprivation Therapy in Hormone Sensitive Prostate Cancer -- 76. Chemotherapy and Novel Systemic Approaches in the Treatment of Metastatic Castration Resistant Prostate Cancer -- 77. Immunotherapy -- 78. Bone Health: Prevention of Skeletal Related Events and Palliative Care -- Section 7: Outcomes and Complications After Treatment -- 79. Assessment of Treatment Outcomes Following Prostate Cancer Therapy -- 80. Urinary Incontinence -- 81. Erectile Dysfunction -- 82. Immediate/Early Surgical Complications -- 83. Population-Based Outcomes Following Treatment of Clinically-Localized Prostate Cancer -- 84. Management of Radiation Adverse Effects -- 85. Management of Complications Following Minimally Invasive Prostate Cancer Therapy -- Section 8: Management of Emergencies and Palliative Care -- 86. Prostate Cancer Emergencies -- 87. Management of Bone Metastases -- 88. Pain Relief in Metastatic Cancer -- 89. The Psycho-Social Impact of Prostate Cancer -- 90. Nursing Issues in Prostate Cancer.
Format
e-Book
Location
Online
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Urological Men's Health : A Guide for Urologists and Primary Care Physicians

https://libcat.nshealth.ca/en/permalink/provcat31025
editor, Daniel A. Shoskes. --New York, NY: Humana Press , c2012.
Available Online
View e-Book
Location
Online
Urological Men's Health: A Guide for Urologists and Primary Care Physicians covers the major urologic conditions that have an impact on the health and well being of the adult male. It opens with an overview of general men's preventative health, as practiced by a world leading Executive Health center. The volume covers the major genitourinary malignancies and addresses the latest controversies in screening and treatment selection. This is followed by coverage of the conditions that don't shorten…
Available Online
View e-Book
Author
Shoskes, Daniel A
Responsibility
editor, Daniel A. Shoskes
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2012
Physical Description
1 online resource (x, 215 p. : 38 ill., 25 ill. in color)
Series Title
Current clinical urology
ISBN
9781617799006
Subjects (MeSH)
Male Urogenital Diseases
Men's Health
Andrology
Subjects (LCSH)
Family medicine
Internal medicine
Urology
Abstract
Urological Men's Health: A Guide for Urologists and Primary Care Physicians covers the major urologic conditions that have an impact on the health and well being of the adult male. It opens with an overview of general men's preventative health, as practiced by a world leading Executive Health center. The volume covers the major genitourinary malignancies and addresses the latest controversies in screening and treatment selection. This is followed by coverage of the conditions that don't shorten life but have major impact on quality of life and health care expenditure: BPH, urinary incontinence, infertility, urethral strictures, erectile dysfunction, urinary tract infections and chronic pelvic pain. Also included are chapters on herbal and complementary therapy, psychological and spousal support in urologic illness and the links between genitourinary disease and general vascular endothelial dysfunction.Urological Men's Health: A Guide for Urologists and Primary Care Physicians will be of great value to Urologists, Internists, General Practitioners and the residents and fellows who train within these specialties.
Contents
1. Evidence Based and Age Appropriate Preventative Health Evaluations in Men -- 2. Clinical Testing Of Endothelial Function In Erectile Dysfunction -- 3. Controversies and Opportunities for PSA Screening -- 4. A Phenotypic Approach to the Evaluation and Treatment of Men with Chronic Pelvic Pain Syndrome -- 5. Recurrent Urinary Tract Infection in Men -- 6. Evaluation and Medical Management of BPH and LUTS in Men -- 7. The Surgical Treatment of Benign Prostatic Hyperplasia (BPH) -- 8. Rational Herbal and Complementary Interventions for Prevention and Treatment of Urological Disorders in Men -- 9. Androgen Decline in the Aging Male: Making Sense of the "Male Menopause" -- 10. Evaluation and Treatment of Peyronie's Disease -- 11. Primary Care Evaluation and Treatment of Erectile Dysfunction -- 12. Surgical Treatment for Erectile Dysfunction -- 13. Managing Overactive Bladder and Urinary Incontinence in the Male -- 14. Treatment of Localized Prostate Cancer -- 15. Management of Urethral Strictures in Men -- 16. Medical and Surgical Interventions in Male Fertility -- 17. Evaluation and Therapy of Chronic Scrotal Content Pan and Epididymitis -- 18. Psychosocial Factors in Painful Urogenital Conditions in Men.
Format
e-Book
Location
Online
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