This book summarizes how the renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction and reviews the action of angiotensin converting enzyme inhibitors and AT1 receptor antagonists on reducing morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. ACEi and ARBS in Hypertension and Heart Failure is a highly practical reference reviewi…
Aspirin has been in clinical use for over 100 years, making it one of the oldest commonly used drugs in medicine, and is now predominantly used as an antiplatelet agent. Major new antiplatelet drug classes have recently become available for the clinician that offer the promise of major improvements in the treatment and prevention of arterial thrombotic disease. In the field of anticoagulation, the vitamin K antagonists such as warfarin have not been available for as long as aspirin in the antip…
This book considers paradigmatic clinical cases in order to cast light on key issues relating to elective or emergency stent implantation and the use of oral anticoagulation (OAC) in patients with atrial fibrillation. The topics addressed include the optimal periprocedural antithrombotic treatment (uninterrupted vs interrupted OAC, intraprocedural use of heparin and glycoprotein IIb/IIIa inhibitors, etc.), the most appropriate type of stent (bare metal vs drug eluting vs "bioactive"), the optim…
This book provides a concise yet comprehensive summary of the current state of knowledge concerning the pathophysiology, differential diagnosis and treatment options that support day-to-day patient management. It reviews a variety of treatments including TOP-R antagonists, along with Syk inhibitor, which has recently proven to be effective, enabling readers to update and broaden their knowledge of the disease. Covering topics ranging from basic science to clinical practice, Autoimmune Thrombocy…
This pamphlet will inform the reader about beta blockers and how to use them. The pamphlet explains what this type of medication is used for and how to take it. Other topics covered in the pamphlet are: who should not take this medication, how to store this medication, what to do if you miss a dose, and medicines and foods to avoid. Symptoms that would need to be evaluated by a physician in the Emergency Department are listed.
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit …
This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that these drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researcher…
Calcium channel blockers are used to treat chest pain and to control high blood pressure. A list of brand names is given. This pamphlet explains how to take calcium channel blockers, drugs and foods to avoid, warnings, possible side effects, and symptoms that you should mention to your doctor, nurse practitioner, or pharmacist.
This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Propert…
This book sheds new light on central pain, a field that is largely obscured by lack of knowledge among pain professionals at all levels, including high-end pain centers. As a matter of fact, central pain, classified as a form of neuropathic pain, remains too often a scourge for those affected due to the ignorance of pain therapists worldwide and enduring misconceptions at the academic level. By weighing up the relevant evidence, the authors aim to remedy the situation by providing clear-cut, no…
The Clinical Handbook of Psychotropic Drugs has become a standard reference and working tool for psychiatrists, psychologists, physicians, pharmacists, nurses, and other mental health professionals. Independent, unbiased. Packed with unique, easy-to-read comparison charts and tables (dosages, side effects, pharmacokinetics, interactions) for a quick overview of treatment options. Succinct, bulleted information on all classes of medication: on- and off-label indications, side effects, interactio…
The Clinical Handbook of Psychotropic Drugs has become a standard reference and working tool for psychiatrists, psychologists, physicians, pharmacists, nurses, and other mental health professionals. Independent, unbiased. Packed with unique, easy-to-read comparison charts and tables (dosages, side effects, pharmacokinetics, interactions) for a quick overview of treatment options. Succinct, bulleted information on all classes of medication: on- and off-label indications, side effects, interactio…
Edited by master clinician-experts appointed by the American Academy of Pain Medicine, this is a state-of-the-art multidisciplinary textbook covering medical, interventional, and integrative approaches to the treatment and management of pain. It is designed as a practical and comprehensive primary reference for busy physicians and is also an up-to-date resource for preparing for certification examinations in pain medicine. Written and edited by world-class authorities -- 'Key Points' preview c…
Designed and written by a team of clinically established academics, this is a unique book that is an excellent manual for physicians practicing pain medicine or treating pain in neurosurgery, orthopedic, neurology, or family practice clinics. As a practical resource, this book is written to be more accessible to the reader and is designed to be more clinically-focused and useful in day-to-day practice. This 102 chapter volume is divided into seven separate sections: Anatomy and Physiology of Pa…
A well-illustrated and comprehensive analysis of the treatment of diabetic retinopathy, this book covers current treatment options and guidelines, whilst also providing a detailed discussion of emerging therapeutic targets. Existing therapeutic options are covered in depth, with a major focus on anti-vascular endothelial growth factor drugs and sustained release corticosteroids, including a review of trial results supporting current treatment guidelines. The use of agents off-label is also disc…
This book provides an overview of pulmonary hypertensive diseases, the current understanding of their pathobiology, and a contemporary approach to diagnosis and treatment. It discusses the definition and classification of these disorders and the epidemiology of pulmonary arterial hypertension (PAH); explores the approach to diagnosis and evaluation via methods such as echocardiography, right heart catheterization, and cardiopulmonary exercise testing; describes the major drug classes used to tr…
The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders such as myeloid leukemias and preleukemias (myelodysplasias) is now being translated into treatment approaches that target the epigenetic defects pharmacologically. Such approaches include reactivation of tumor suppressor genes and other antiproliferative genes by reversal of DNA hypermethylation through azanucleosides, and use of HDAC inhibitors to reverse gene silencing mediated by chim…
In anesthesiology, pain medicine, and critical care, practitioners at all levels need help to stay current with the continually evolving drug knowledge-base, and trainees need tools to prepare for in-training and board exams that increasingly test their knowledge of pharmacology. This practical book is aimed at both readerships. It features a unique and practical chapter on the United States Food and Drug Administration (FDA) "black box" warnings that describe what safety precautions should be …
Written by experts in the field, this clinical handbook explores the novel SGLT2 drug class for the treatment of diabetes. This book includes evidence-based guidelines, major clinical trials, and a discussion of treatment options currently available, as well as those currently in development. Essentials of SGLT2 Inhibitors is an ideal educational resource for busy medical professionals who need to stay up-to-date with diabetes treatment advances in order to provide the best possible clinical ca…
This book covers a wide range of disorders such as atrial fibrillation, artificial heart valves, deep vein thrombosis, pulmonary embolism and stroke. Handbook of Oral Anticoagulation aims to provide an accessible overview of the exciting new developments in this field. Incorporating numerous quick-reference tables and figures and fully referenced throughout to key papers and the latest reviews, it will be a useful resource for all healthcare professionals involved in thromboprophylaxis.