Clinical pharmacokinetic and pharmacodynamic drug interactions associated with antimalarials
https://libcat.nshealth.ca/en/permalink/provcat33949
Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom.
--Cham, Switzerland:
Adis
, c2015.
- Available Online
- View e-Book
- Location
- Online
This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarize…
- Available Online
- View e-Book
- Author
- Kiang, Tony K. L
- Other Authors
- Wilby, Kyle John
- Ensom, Mary H.H.
- Responsibility
- Tony K.L. Kiang, Kyle John Wilby, Mary H.H. Ensom
- Place of Publication
- Cham, Switzerland
- Publisher
- Adis
- Date of Publication
- c2015
- Physical Description
- 1 online resource (vii, 146 pages)
- ISBN
- 9783319105277 (electronic bk.)
- 9783319105260
- Subjects (MeSH)
- Antimalarials - pharmacokinetics
- Drug interactions
- Malaria - drug therapy
- Abstract
- This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.
- Contents
- Introduction -- Pharmacology of Recommended Antimalarial Agents -- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials -- Pharmacokinetic Drug Interactions Affecting Antimalarials -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs -- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials -- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions -- Limitations, Future Directions, and Conclusions.
- Format
- e-Book
- Location
- Online
Drug Interactions in Infectious Diseases
https://libcat.nshealth.ca/en/permalink/provcat30018
Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai, editors.
(3rd ed.)
--Totowa, NJ:
Springer Science+Business Media
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Piscitelli, Stephen C
- Rodvold, Keith A
- Pai, Manjunath P
- Responsibility
- Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai, editors
- Edition
- 3rd ed.
- Place of Publication
- Totowa, NJ
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2011
- Series Title
- Infectious disease
- ISBN
- 9781617792137
- Subjects (MeSH)
- Anti-Infective Agents - pharmacology
- Anti-Infective Agents - therapeutic use
- Communicable Diseases - drug therapy
- Communicable Diseases - complications
- Drug Interactions
- Subjects (LCSH)
- Pharmacy
- Infectious diseases
- Contents
- 1. Introduction to Drug-Drug Interactions -- 2. Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- 3. Mechanisms of Drug Interactions II: Transport Proteins -- 4. Drug-Food Interactions -- 5. Interactions Between Herbs and Antiinfective Medications -- 6. Drug-Cytokine Interactions -- 7. Beta-Lactam Antibiotics -- 8. Macrolides, Azalides, and Ketolides -- 9. Quinolones -- 10. Glycopeptides, Lipopeptides, and Lipoglycopeptides -- 11. Miscellaneous Antibiotics -- 12. Drugs for Tuberculosis -- 13. Drug Interactions with Antiretrovirals for HIV Infection -- 14. Non-HIV Antiviral Agents -- 15. Antifungal Agents -- 16. Antimalarial Agents -- 17. Antiprotozoal and Anthelmintic Agents -- 18. Drug Interaction Considerations Throughout Drug Development -- 19. Probe Cocktail Studies -- 20. Design and Data Analysis in Drug Interaction Studies.
- Format
- e-Book
- Location
- Online
Drug Interactions in Infectious Diseases : Antimicrobial Drug Interactions
https://libcat.nshealth.ca/en/permalink/provcat43114
Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors.
(Fourth edition)
--Cham:
Humana Press
, c2018.
- Available Online
- View e-Book
- Location
- Online
The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Antimicrobial Drug Interactions," delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for…
- Available Online
- View e-Book
- Other Authors
- Pai, Manjunath P.
- Kiser, Jennifer J.
- Gubbins, Paul O.
- Rodvold, Keith A
- Responsibility
- Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors
- Edition
- Fourth edition
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xvi, 565 p.) : 2 illus., 1 illus. in color
- Series Title
- Infectious disease
- ISBN
- 9783319724164
- 9783319724157 (print ed.)
- 9783319724171 (print ed.)
- 9783030101978 (print ed.)
- Subjects (MeSH)
- Anti-Infective Agents - pharmacology
- Anti-Infective Agents - therapeutic use
- Communicable Diseases - drug therapy
- Drug Interactions
- Specialty
- Infectious Disease Medicine
- Pharmacology
- Abstract
- The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Antimicrobial Drug Interactions," delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
- Contents
- Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions in HIV: Protease and Integrase Inhibitors -- Drug Interactions in HIV: Nucleoside, Nucleotide, and Nonnucleoside Reverse Transcriptase Inhibitors and Entry Inhibitors -- Hepatitis B and Hepatitis C Antiviral Agents -- Drug Interactions of Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelminthic Agents.
- Format
- e-Book
- Location
- Online
Ethics and Drug Resistance : Collective Responsibility for Global Public Health
https://libcat.nshealth.ca/en/permalink/provcat45707
Euzebiusz Jamrozik, Michael Selgelid, editors.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This open access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use…
- Available Online
- View e-Book
- Other Authors
- Jamrozik, Euzebiusz
- Selgelid, Michael
- Responsibility
- Euzebiusz Jamrozik, Michael Selgelid, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xvii, 448 p.) : 1 illus.
- Series Vol.
- 5
- Series Title
- Public health ethics analysis
- ISBN
- 9783030278748
- 9783030278731 (Print ed.)
- 9783030278755 (Print ed.)
- 9783030278762 (Print ed.)
- ISSN
- 2211-6680
- Subjects (MeSH)
- Antimicrobial Stewardship - ethics
- Bioethical Issues
- Subjects (LCSH)
- Bioethics
- Drug resistance
- Infectious diseases
- Specialty
- Ethics
- Infectious Disease Medicine
- Pharmacy
- Abstract
- This open access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.
- Contents
- Part I. Ethics and Drug Resistance in Context -- 1. Drug-Resistant Infection: Causes, Consequences, and Responses -- 2. Preventive Therapy for Multidrug Resistant Latent Tuberculosis Infection: An Ethical Imperative with Ethical Barriers to Implementation? -- 3. Providing Universal Access While Avoiding Antiretroviral Resistance: Ethical Tensions in HIV Treatment -- 4. Ethics and Antimalarial Drug Resistance -- 5. Antimicrobial Resistance and the Private Sector in Southeast Asia -- 6. Hospital Infection Prevention and Control (IPC) and Antimicrobial Stewardship (AMS): Dual Strategies to Reduce Antibiotic Resistance (ABR) in Hospitals -- 7. Epidemiology and Ethics of Antimicrobial Resistance in Animals -- Part II. Theoretical Approaches to Ethics and Drug Resistance -- 8. The Virtuous Physician and Antimicrobial Prescribing Policy and Practice -- 9. Moral Responsibility and the Justification of Policies to Preserve Antimicrobial Effectiveness -- 10. Access to Effective Diagnosis and Treatment for Drug-Resistant Tuberculosis: Deepening the Human Rights-Based Approach -- 11. The Right to Refuse Treatment for Infectious Disease -- 12. Surveillance and Control of Asymptomatic Carriers of Drug-Resistant Bacteria -- 13. Conceptualizing the Impact of MDRO Control Measures Directed at Carriers: A Capability Approach -- 14. A Capability Perspective on Antibiotic Resistance, Inequality, and Child Development -- 15. Fairness in the Use of Information About Carriers of Resistant Infections -- 16. Antimicrobial Resistance and Social Inequalities in Health: Considerations of Justice -- 17. The Economics of Resistance Through an Ethical Lens -- Part III. Ethics, Regulation, Governance, and Drug Resistance -- 18. Antibiotics and Animal Agriculture: The Need for Global Collective Action -- 19. Technological Fixes and Antimicrobial Resistance -- 20. Tackling Anti-microbial Resistance: An Ethical Framework for Rational Antibiotic Use -- 21. Solidarity and Antimicrobial Resistance -- 22. Justifying Antibiotic Resistance Interventions: Uncertainty, Precaution and Ethics -- 23. Antimicrobial Footprints, Fairness, and Collective Harm -- 24. Global Health Governance and Antimicrobial Resistance -- 25. Global Governance of Anti-microbial Resistance: A Legal and Regulatory Toolkit -- 26. The Super-Wicked Problem of Antimicrobial Resistance.
- Format
- e-Book
- Location
- Online
Malaria : genetic and evolutionary aspects
https://libcat.nshealth.ca/en/permalink/provcat40965
[edited by] Krishna R. Dronamraju and Paolo Arese.
--New York, NY:
Springer
, c2006.
- Available Online
- View e-Book
- Location
- Online
This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There wer…
- Available Online
- View e-Book
- Author
- Dronamraju, Krishna R.
- Other Authors
- Arese, Paolo
- Responsibility
- [edited by] Krishna R. Dronamraju and Paolo Arese
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2006
- Physical Description
- 1 online resource (xi, 190 p. : ill.)
- Series
- Emerging Infectious Diseases of the 21st Century
- Series Vol.
- 4
- ISBN
- 9780387282954
- 9780387282947 (print ed.)
- Subjects (MeSH)
- Evolution, Molecular
- Malaria - genetics
- Malaria - prevention & control
- Abstract
- This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane’s malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration.
- Contents
- Introduction -- J.B.S. Haldane (1892-1964) -- Removal of Early Parasite Forms from Circulation as a Mechansism of Resistance Against Malaria in Widespread Red Blood Cells Mutations -- Clinical, Epidemiological and Genetic Investigations on Thalassemia and Malaria in Italy -- Resistance to Antimalarial Drugs: Parasite and Host Genetic Factors -- Evolutionary Origins on Human Malaria Parasites -- The Rate of Mutation of Human Genes -- Disease and Evolution.
- Format
- e-Book
- Location
- Online
