Abeta Peptide and Alzheimer's Disease : Celebrating a Century of Research
https://libcat.nshealth.ca/en/permalink/provcat40582
Colin J. Barrow and David H. Small (eds.).
--London:
Springer
, c2007.
- Available Online
- View e-Book
- Location
- Online
Abeta Peptide and Alzheimer's Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer's Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although…
- Available Online
- View e-Book
- Other Authors
- Barrow, Colin J
- Small, David H
- Responsibility
- Colin J. Barrow and David H. Small (eds.)
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2007
- Physical Description
- 1 online resource (xi, 298 p.)
- ISBN
- 9781846284403
- 9781852339616 (print ed.)
- Subjects (MeSH)
- Alzheimer Disease - etiology
- Alzheimer Disease - metabolism
- Amyloid beta-Peptides - metabolism
- Abstract
- Abeta Peptide and Alzheimer's Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer's Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinson's and Huntington's. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.
- Contents
- A Brief Introduction to the History of the ß-Amyloid Protein (Aß) of Alzheimer’s Disease -- The Aßcentric Pathway of Alzheimer's Disease -- The Function of the Amyloid Precursor Protein Family -- The Involvement of Aß in the Neuroinflammatory Response -- Amyloid ß-Peptide(1-42), Oxidative Stress, and Alzheimer's Disease -- Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease -- Aß Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression -- Copper Coordination by ß-Amyloid and the Neuropathology of Alzheimer's Disease -- Cholesterol and Alzheimer's Disease -- Amyloid ß-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer's Disease Pathology -- Physiologic and Neurotoxic Properties of Aß Peptides -- Impact of ß-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models -- Glial Cells and Aß Peptides in Alzheimer's Disease Pathogenesis -- The Role of Presenilins in Aß-Induced Cell Death in Alzheimer's Disease -- Immunotherapeutic Approaches to Alzheimer's Disease -- Mouse Models of Alzheimer's Disease.
- Format
- e-Book
- Location
- Online
Abeta peptide and Alzheimer's disease : celebrating a century of research
https://libcat.nshealth.ca/en/permalink/provcat23501
Barrow, Colin J.
--London, England:
Springer
, 2007.
- Call Number
- WT 155 A147 2007
- Location
- Halifax Infirmary
- Call Number
- WT 155 A147 2007
- Author
- Barrow, Colin J
- Other Authors
- Small, David H
- Place of Publication
- London, England
- Publisher
- Springer
- Date of Publication
- 2007
- Physical Description
- 298 p.
- ISBN
- 9781852339616
- Subjects (MeSH)
- Amyloid beta-Peptides - metabolism
- Alzheimer Disease - etiology
- Format
- Book
- Location
- Halifax Infirmary
- Loan Period
- 3 weeks
Adverse cutaneous drug reactions to cardiovascular drugs
https://libcat.nshealth.ca/en/permalink/provcat33470
Esen Özkaya, Kurtulus Didem Yazganoglu.
--London:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This book describes adverse cutaneous drug reactions as among the most frequent events in patients receiving drug therapy. Cardiovascular drugs are an important group as there are a greater number of indications for the use of new drugs and their prescription continues to increase. The exact incidence of cutaneous side effects from cardiovascular drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable connection between a certain drug and a certain type of reaction can on…
- Available Online
- View e-Book
- Author
- Özkaya, Esen
- Other Authors
- Yazganoglu, K. Didem
- Responsibility
- Esen Özkaya, Kurtulus Didem Yazganoglu
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xxi, 259 pages)
- ISBN
- 9781447165361 (electronic bk.)
- 9781447165354
- Subjects (LCSH)
- Cardiovascular agents - Side effects
- Dermatopharmacology
- Dermatology
- Cardiology
- Abstract
- This book describes adverse cutaneous drug reactions as among the most frequent events in patients receiving drug therapy. Cardiovascular drugs are an important group as there are a greater number of indications for the use of new drugs and their prescription continues to increase. The exact incidence of cutaneous side effects from cardiovascular drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable connection between a certain drug and a certain type of reaction can only rarely be made, aside from the well-known angioedema/urticaria from angiotensin-converting enzyme inhibitors, lichen planus/lichenoid reaction from beta adrenergic blockers, and photosensitivity from thiazid diuretics. These reactions can extend to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis and drug hypersensitivity syndrome. Adverse Cutaneous Drug Reactions To Cardiovascular Drugs reviews the reported types of reactions to cardiovascular drugs. Each is discussed according to drug class and the type of dermatologic reaction with special emphasize on cross-reactions and the role of patch testing in diagnosis. A total of 116 images are included featuring clinical appearance of common adverse cutaneous drug reactions and diagnostic procedures such as patch and photopatch testing with the suspected drugs. Complementary tables may allow to scan the most common cutaneous reactions and the related cardiovascular drugs along with the possible cross reactions at first glance. It will thus be of considerable importance to all dermatologists and medical professionals who manage the skin, while being an important reference resource for cardiologists in terms of identifying potential adverse reactions to the drugs they prescribe..
- Contents
- Part I. General Aspects of Adverse Cutaneous Drug Reactions -- 1. General Aspects of Adverse Cutaneous Drug Reactions -- Part II. Adverse Cutaneous Drug Reactions to Specific Class of Cardiovascular Drugs -- 2. Angiotensin-Converting Enzyme Inhibitors -- 3. Angiotensin II Receptor Blockers -- 4. Alpha-2 Adrenergic Receptor Agonists -- 5. Class I Antiarrhythmic Drugs -- 6. Beta Adrenergic Receptor Blockers (Class II Antiarrhythmics) -- 7. Class III Antiarrhythmic Drugs -- 8. Calcium Channel Blockers -- 9. Diuretics -- 10. Vasodilatory Drugs -- 11. Lipid-Lowering Drugs -- 12. Platelet Inhibitors -- 13. Thrombolytics -- 14. Anticoagulants -- 15. Other Cardiovascular Drugs -- Part III. Patch Testing in Drug Eruptions -- 16. Patch Testing in Drug Eruptions.
- Format
- e-Book
- Location
- Online
Angiogenesis-Based Dermatology
https://libcat.nshealth.ca/en/permalink/provcat41220
Jack L. Arbiser, editor.
--London:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book covers in detail all aspects of angiogenesis in dermatology. Angiogenesis is a principle that can be used to guide treatment of diseases of any organ system. Dermatologists already inhibit angiogenesis as part of their treatment of multiple common dermatologic disorders, including acne, warts, and nonmelanoma skin cancer. Angiogenesis-Based Dermatology encompasses information and knowledge from a diverse background of related topics to enable readers to have a full understanding of th…
- Available Online
- View e-Book
- Other Authors
- Arbiser, Jack L
- Responsibility
- Jack L. Arbiser, editor
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (x, 176 pages) : 48 illus., 47 illus. in color
- ISBN
- 9781447173144
- 9781447173120 (print ed.)
- Subjects (MeSH)
- Neovascularization, Pathologic
- Neovascularization, Physiologic
- Skin Diseases - therapy
- Abstract
- This book covers in detail all aspects of angiogenesis in dermatology. Angiogenesis is a principle that can be used to guide treatment of diseases of any organ system. Dermatologists already inhibit angiogenesis as part of their treatment of multiple common dermatologic disorders, including acne, warts, and nonmelanoma skin cancer. Angiogenesis-Based Dermatology encompasses information and knowledge from a diverse background of related topics to enable readers to have a full understanding of the subject in order to optimally manage patients with this group of diagnoses. It provides a guide to the principles of angiogenesis that will allow all involved in dermatology from the medical student and nurse practitioner to the experienced dermatologist to apply these principles for the treatment of patients.
- Contents
- Angiogenesis: General Concepts -- Infantile Hemangioma: New Insights on Pathogenesis and Beta Blockers Mechanisms of Action -- The Role of Angiogenesis in the Development of Psoriasis -- Angiogenesis and Nonmelanoma Skin Cancer -- Melanoma -- Potential Role of Angiogenesis and Lymphangiogenesis in Atopic Dermatitis: Evidence from Human Studies and Lessons from an Animal Model of Human Disease -- Chemoprevention and Angiogenesis -- Angiogenesis and Pathogenesis of Port Wine Stain and Infantile Hemangiomas.
- Format
- e-Book
- Location
- Online
Antiarrhythmic Drugs
https://libcat.nshealth.ca/en/permalink/provcat44884
Antoni Martínez-Rubio, Juan Tamargo, Gheorghe- Andrei Dan, editors.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know…
- Available Online
- View e-Book
- Other Authors
- Martínez-Rubio, Antoni
- Tamargo, Juan
- Dan, Gheorghe- Andrei
- Responsibility
- Antoni Martínez-Rubio, Juan Tamargo, Gheorghe- Andrei Dan, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (viii, 428 p.) : 35 illus., 29 illus. in color
- Series Title
- Current cardiovascular therapy
- ISBN
- 9783030348939
- 9783030348915 (Print ed.)
- 9783030348922 (Print ed.)
- Specialty
- Cardiology
- Pharmacology
- Abstract
- This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis.
- Contents
- 1. Mechanisms of Cardiac Arrhythmias -- 2. Class I Antiarrhythmic Drugs: Na+ Channel Blockers -- 3. Class III Antiarrhythmic Drugs -- 4. Beta-blockers as Antiarrhythmic Agents -- 5. Modulation of Calcium Handling: Calcium-Channel Modulators -- 6. Other Antiarrhythmic Drugs -- 7. Antiarrhythmic Properties of Non-Antiarrhythmic Drugs in Atrial Fibrillation: Upstream Therapy -- 8. Clinical Significance and Management of Arrhythmias.
- Format
- e-Book
- Location
- Online
Birth, distress, and disease : placental-brain interactions
https://libcat.nshealth.ca/en/permalink/provcat27226
edited by Michael L. Power and Jay Schulkin.
--Cambridge, UK:
Cambridge University Press
, c2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Power, Michael L
- Other Authors
- Schulkin, Jay
- Responsibility
- edited by Michael L. Power and Jay Schulkin
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- c2005
- Physical Description
- 279 p.
- ISBN
- 6610223912
- Subjects (MeSH)
- Maternal-Fetal Exchange
- Fetal Development
- Prenatal Exposure Delayed Effects
- Disease Susceptibility
- Contents
- Cover -- Half-title -- Title -- Copyright -- Dedication -- Table of Contents -- List of contributors -- Preface -- Introduction: brain and placenta, birth and behavior, health and disease -- Preterm birth -- Origins of adult-onset disease -- Feed-forward regulation of CRH by glucocorticoids -- REFERENCES -- 1 Placental expression of neurohormones and other neuroactive molecules in human pregnancy -- Introduction -- Neurosteroids and monoamines -- Peptide signaling and placental endocrinology -- CRH, CRH-BP and urocortin -- Placental control of ACTH secretion -- CRH and pathologies of pregnancy -- Peptide signaling and fetal/maternal endocrinology -- Peptide signaling and the control of myometrial contractility -- (A) Role of OT -- (B) Role of CRH -- (C) Role of opioids -- (D) Role of NPY and CGRP -- (E) Role of PTHrP -- Peptide signaling and the control of fetal...placental blood flow -- (A) Effects of CRH and NPY -- (B) Effect of CGRP -- (C) Effect of PTHrP -- Inhibin-related peptides -- Placental control of hCG secretion -- Conclusions -- REFERENCES -- 2 The regulation of human parturition -- Clues from parturition in mammals -- Conflict as a source of evolutionary drive -- The endocrinology of parturition in primates -- CRH and the timing of birth in humans -- Regulation of placental CRH production -- Mechanisms proposed to link CRH to the process of parturition -- Activation of the human myometrium -- REFERENCES -- 3 Maternal nutrition and metabolic control of pregnancy -- Nutrition and pregnancy outcome -- CRH-cortisol -- Feeding, fasting, cortisol, and CRH -- Leptin -- GH-IGF -- Animal models: need for diversity -- Conclusions -- REFERENCES -- 4 Fetal HPA activation, preterm birth and postnatal programming -- The fetal HPA axis -- The developmental programming of adult disease -- Prenatal glucocorticoid exposure and fetal programming -- The placenta and prenatal stress -- Antenatal administration of glucocorticoids -- Adult disease and programming HPA axis function: human and animal evidence -- Prenatal glucocorticoid exposure and postnatal metabolic function: type 2 diabetes -- Concluding remarks -- REFERENCES -- 5 Prenatal glucocorticoids and the programming of adult disease -- Epidemiology and the concept of 'programming' -- Programming -- Glucocorticoid programming -- Steroids and organizational effects -- Why glucocorticoids? -- Glucocorticoids and tissue maturation -- Glucocorticoids and the low-birth-weight baby syndrome -- Physiology: placental 11 -HSD-2 -- Placental 11 Beta-HSD-2 and birth weight -- An introduction to experimental studies of early life glucocorticoid exposure -- Peripheral programming -- Blood pressure and cardiovascular control -- Mechanisms of cardiovascular programming by prenatal glucocorticoids -- Programming the heart? -- Programming of glucose...insulin homoeostasis and metabolic functions -- Mechanisms of glucocorticoid-programmed hyperglycaemia/insulin resistance -- Programming of hepatic 11Beta-HSD-1? -- Programming the pancreas -- Adipose tissue and programming: an emerging area? --tidtid2
- Format
- e-Book
- Location
- Online
Bone Morphogenetic Proteins : Systems Biology Regulators
https://libcat.nshealth.ca/en/permalink/provcat41581
Slobodan Vukicevic, Kuber T. Sampath, editors.
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit …
- Available Online
- View e-Book
- Other Authors
- Vukicevic, Slobodan
- Sampath, Kuber T
- Responsibility
- Slobodan Vukicevic, Kuber T. Sampath, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xii, 445 pages) : 43 illus., 32 illus. in color
- Series Title
- Progress in inflammation research
- ISBN
- 9783319475073
- 9783319475059 (print ed.)
- Abstract
- This book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
- Contents
- Historical Perspective of Bone Morphogenetic Proteins -- The Systems Biology of Bone Morphogenetic Proteins -- Embryonic Skeletogenesis and Craniofacial Development -- BMP and BMP Regulation: Structure and Function -- Novel In Vitro Assay Models to Study Osteogenesis and Chondrogenesis for Human Skeletal Disorders -- Toward Advanced Therapy Medicinal Products (ATMPs) Combining Bone Morphogenetic Proteins (BMP) and Cells for Bone Regeneration -- BMP Signaling in Articular Cartilage Repair and Regeneration: Potential Therapeutic Opportunity for Osteoarthritis -- BMPs in Orthopaedic Medicine: Promises and Challenges -- Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction -- Biology of Spine Fusion and Application of Osteobiologics in Spine Surgery -- BMPs in Dental Medicine: Promises and Challenges -- Bone Morphogenetic Protein-7 and Its Role in Acute Kidney Injury and Chronic Kidney Failure -- Bone Morphogenetic Protein Signaling in Pulmonary Arterial Hypertension -- BMP Signaling in Fibrodysplasia Ossificans Progressiva, a Rare Genetic Disorder of Heterotopic Ossification -- The Central Role of BMP Signaling in Regulating Iron Homeostasis -- BMPs in Inflammation -- Physiological and Pathological Consequences of Vascular BMP Signaling -- Bone Morphogenetic Proteins in the Initiation and Progression of Breast Cancer.
- Format
- e-Book
- Location
- Online
Brain norepinephrine : neurobiology and therapeutics
https://libcat.nshealth.ca/en/permalink/provcat27288
edited by Gregory A. Ordway, Michael A. Schwartz, Alan Frazer.
--Cambridge, UK:
Cambridge University Press
, 2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Ordway, Gregory A
- Other Authors
- Schwartz, Michael A
- Frazer, Alan
- Responsibility
- edited by Gregory A. Ordway, Michael A. Schwartz, Alan Frazer
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- 2007
- Physical Description
- 642 p.
- ISBN
- 6610815321
- Subjects (MeSH)
- Norepinephrine
- Contents
- Cover -- Half-title -- Title -- Copyright -- Contents -- Contributors -- Acknowledgements and Disclosures -- Introduction: revision of an old transmitter -- Part I The neurobiology of norepinephrine -- 1 Neuroanatomical and chemical organization of the locus coeruleus -- Early history of the locus coeruleus -- Species comparisons -- Ontogeny -- Morphological and ultrastructural characteristics -- Transmitter identity and receptor distribution -- Connections: sources of afferent input to LC -- The LC efferent projection -- Chemoarchitecture: neurochemically identified pathways -- Overview -- REFERENCES -- 2 Interactions of norepinephrine with other neurotransmitter systems: anatomical basis and pharmacology -- Introduction -- Noradrenergic circuitry: input to the LC -- Noradrenergic circuitry: reciprocal output from the LC -- Summary and conclusions -- Acknowledgements -- REFERENCES -- 3 Receptors for norepinephrine and signal transduction pathways -- Introduction -- Adrenergic receptor subtypes -- Characteristics of alpha1-adrenergic receptors -- Characteristics of alpha2-adrenergic receptors -- Characteristics of beta-adrenergic receptors -- Signal transduction pathways -- Physiological roles -- Conclusions/summary -- REFERENCES -- 4 Regulation of gene transcription in the central nervous system by norepinephrine -- Introduction -- Fundamental concepts of gene transcription -- Noradrenergic receptors couple to multiple signal transduction cascades and transcription factors -- Role of noradrenergic receptor regulation of transcription factors and gene expression in the actions of antidepressant treatment -- Antidepressants and norepinephrine regulation of c-fos gene expression and AP-1 DNA binding -- Role of NE-CREB signaling in learning and memory -- Conclusions -- Acknowledgements -- REFERENCES -- 5 The norepinephrine transporter and regulation of synaptic transmission -- Introduction -- The norepinephrine transporter and the importance of norepinephrine uptake -- Regulation of norepinephrine uptake -- Norepinephrine transporter-associated proteins -- Norepinephrine transporter gene, polymorphisms and splice variants -- Clearance of norepinephrine and aging -- Norepinephrine transport and disease -- Conclusions -- Acknowledgements -- References -- Part II Norepinephrine and behavior -- 6 Role of the locus coeruleus-norepinephrine system in arousal and circadian regulation of the sleep-wake cycle -- Introduction -- Brain systems involved in sleep-wake regulation -- LC involvement in sleep-wake regulation -- Role of corticotropin-releasing factor in noradrenergic regulation of sleep and waking -- Role of LC in circadian regulation of sleep and waking -- Clinical perspectives: LC participation in sleep alterations due to clinical pathologies -- Conclusions -- REFERENCES -- 7 The locus coeruleus and regulation of behavioral flexibility and attention: clinical implications -- Introduction -- Background -- Recent results recording LC neurons in behaving monkeys -- Computational modeling: simulation of LC activity and task performance -- Decision-related activation of monkey LC neurons -- Influence of prefrontal cortex on activity of LC neurons -- Discussion -- Clinical implications -- Hypertonic LC activity: attention-deficit/hyperactivity disorder and posttraumatic stre
- Format
- e-Book
- Location
- Online
Cancer stem cells
https://libcat.nshealth.ca/en/permalink/provcat27740
edited by William L. Farrar.
--Cambridge:
Cambridge University Press
, 2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Farrar, William L
- Responsibility
- edited by William L. Farrar
- Place of Publication
- Cambridge
- Publisher
- Cambridge University Press
- Date of Publication
- 2010
- Physical Description
- 1 online resource (171 p.)
- ISBN
- 9780511605536 (ebook)
- 9780521896283 (hardback)
- Subjects (MeSH)
- Neoplastic stem cells - physiology
- Neoplasms - etiology
- Signal transduction - physiology
- Contents
- Purification and characterization of cancer stem cells / Elaine M. Hurt and William L. Farrar -- Prostate cancer stem cells / Collene R. Jeter and Dean G. Tang -- Melanoma cancer stem cells / Alexander Roesch and Meenhard Herlyn -- Mammospheres and breast carcinoma / Massimiliano Bonafe -- Preventative and therapeutic strategies for cancer stem cells / Stewart Sell and Gennadi Glinsky -- Targeting acute myelogenous leukemia stem cells / Monica L. Guzman, Gerrit J. Schuurhuis, and Craig T. Jordan -- Hedgehog/GLI signaling in cancer / Fritz Aberger -- Targeting notch signaling pathway in cancer stem cells / Joon T. Park, Ie-Ming Shih, and Tian-Li Wang -- TGF-[beta], notch and Wnt in normal malignant stem cells : differentiating agents and epigenetic modulation / Stephen Byers ... [et al.].
- Format
- e-Book
- Location
- Online
Cardiac Drug Therapy
https://libcat.nshealth.ca/en/permalink/provcat39040
M. Gabriel Khan.
(8th ed.)
--Totowa, NJ:
Humana Press
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Propert…
- Available Online
- View e-Book
- Author
- Khan, M. Gabriel
- Responsibility
- M. Gabriel Khan
- Edition
- 8th ed.
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xxxii, 791 p. : 44 illus., 6 illus. in color)
- Series Title
- Contemporary cardiology
- ISBN
- 9781617799624
- 9781617799617 (print ed.)
- ISSN
- 2196-8969
- Subjects (MeSH)
- Cardiovascular Agents - therapeutic use
- Heart Diseases - drug therapy
- Abstract
- This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs are examined. This revised edition is thoroughly updated and addresses the entire spectrum of heart disorders, such as hypertension, angina, myocardial infarction, heart failure, arrhythmias, cardiac arrest, and dyslipidemias. New chapters include endocrine heart diseases, management of cardiomyopathies, and newer agents. In addition, topics such as cardiac drugs in pregnancy and lactation and drug interactions are covered. Cardiac Drug Therapy, Eighth Edition, is an authoritative and clinically relevant resource for cardiologists, cardiology fellows, and internists.
- Contents
- Beta-Blockers: The Cornerstone of Cardiac Drug Therapy -- Beta-Blocker Controversies -- Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers -- ACE Inhibitor Controversies -- Calcium Antagonists (Calcium Channel Blockers) -- Calcium Antagonist Controversies -- Diuretics -- Hypertension -- Hypertension Controversies -- Angina -- Myocardial Infarction -- Heart Failure -- Heart Failure Controversies -- Arrhythmias -- Cardiac Arrest -- Infective Endocarditis -- Dyslipidemias -- Endocrine Heart Diseases -- Antiplatelet Agents, Anticoagulants, Factor XA Inhibitors, and Thrombin Inhibitors -- Cardiac Drugs During Pregnancy and Lactation -- Drug Interactions -- Hallmark Clinical Trials -- Management of Cardiomyopathies -- Newer Agents.
- Format
- e-Book
- Publication Type
- Handbook
- Location
- Online
Cardiovascular Hemodynamics : An Introductory Guide
https://libcat.nshealth.ca/en/permalink/provcat44623
Arman T. Askari, Adrian W. Messerli, editors.
(Second edition)
--Cham:
Humana Press
, c2019.
- Available Online
- View e-Book
- Location
- Online
The second edition of this key resource provides a broad and fundamental overview of basic cardiovascular (CV) hemodynamic principles with a focus on clinical assessment of CV physiology. Extensively updated, the book includes new coverage on noninvasive hemodynamic assessment and the effects of selected interventions on CV hemodynamics. It provides an introduction to the basic concepts such as preload, afterload, myocardial contractility, and cardiac output. Subsequent chapters examine the eff…
- Available Online
- View e-Book
- Other Authors
- Askari, Arman T.
- Messerli, Adrian W.
- Responsibility
- Arman T. Askari, Adrian W. Messerli, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xlvi, 371 p.) : 158 illus., 116 illus. in color
- Series Title
- Contemporary cardiology
- ISBN
- 9783030191313
- 9783030191306 (Print ed.)
- 9783030191320 (Print ed.)
- 9783030191337 (Print ed.)
- ISSN
- 2196-8969
- Subjects (MeSH)
- Cardiovascular Physiological Phenomena
- Hemodynamics
- Specialty
- Cardiology
- Physiology
- Abstract
- The second edition of this key resource provides a broad and fundamental overview of basic cardiovascular (CV) hemodynamic principles with a focus on clinical assessment of CV physiology. Extensively updated, the book includes new coverage on noninvasive hemodynamic assessment and the effects of selected interventions on CV hemodynamics. It provides an introduction to the basic concepts such as preload, afterload, myocardial contractility, and cardiac output. Subsequent chapters examine the effects of interventions such as vasodilators, beta blockers, pressor agents, inotropes, and different forms of invasive circulatory support. The book also focuses on various methods of hemodynamic evaluation including echocardiography, CT/MRI, noninvasive hemodynamic assessment, and cardiac catheterization. The book concludes with a discussion of proper diagnosis, evaluation, and management of patients using hemodynamic data on a variety of specific disease states. An invaluable contribution to the Contemporary Cardiology Series, the Second Edition of Cardiovascular Hemodynamics: An Introductory Guide is an essential resource for physicians, residents, fellows, medical students, and researchers in cardiology, emergency medicine, critical care, and internal medicine.
- Contents
- Part I. Components of Myocardial Performance -- 1. Preload -- 2. Afterload -- 3. Contractility -- 4. Cardiac Output -- Part II. Effects of Selected Interventions on CV Hemodynamics -- 5. Renin Angiotensin Aldosterone Axis Modulators and Other Vasodilators -- 6. Beta Blockers and Calcium Channel Blockers -- 7. Pressor Agents, Pure Inotropes, Mixed Function Agents -- 8. Recently Approved Agents to Improve Outcomes in Heart Failure -- 9. Invasive Circulatory Support – IABP, IMPELLA, LVAD as Destination Therapy -- Part III. Methods of Hemodynamic Evaluation -- 10. Key Clinical Findings -- 11. Echocardiography -- 12. CT/MRI -- 13. Non-invasive Hemodynamic Assessment -- 14. Cardiac Catheterization – RHC/LHC -- Part IV. Specific Hemodynamically Compromised Situations -- 15. Tamponade -- 16. Constriction / Restriction -- 17. Valvular Heart Disease – Including Cases / Issues of TAVR, Mitral Clip -- 18. Pulmonary Hypertension -- 19. Acute Decompensated Heart Failure -- 20. Intracardiac Shunts -- 21. Shock -- 22. Intracoronary Hemodynamics.
- Format
- e-Book
- Location
- Online
The Cleveland Clinic Manual of Dynamic Endocrine Testing
https://libcat.nshealth.ca/en/permalink/provcat39154
Ahmet Bahadir Ergin, A. Laurence Kennedy, Manjula K. Gupta, Amir H. Hamrahian.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
Developed via a peer review process that included 25 experienced endocrinologists and utilizing the best current evidence, The Cleveland Clinic has created a practical set of protocols for over 25 commonly used dynamic endocrine tests. The cornerstone of clinical endocrinology, these evidence-based protocols play an important role in clinical decision-making and are important element of billing and compliance with high quality standards. Included here are various tests for pituitary and adrenal…
- Available Online
- View e-Book
- Author
- Ergin, Ahmet Bahadir
- Other Authors
- Kennedy, A. Laurence
- Gupta, Manjula K
- Hamrahian, Amir H
- Responsibility
- Ahmet Bahadir Ergin, A. Laurence Kennedy, Manjula K. Gupta, Amir H. Hamrahian
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (viii, 124 p. : 23 illus., 3 illus. in color)
- ISBN
- 9783319130484
- 9783319130477 (print ed.)
- Subjects (MeSH)
- Clinical Laboratory Techniques - methods
- Diagnostic Techniques, Endocrine - standards
- Evidence-Based Medicine
- Abstract
- Developed via a peer review process that included 25 experienced endocrinologists and utilizing the best current evidence, The Cleveland Clinic has created a practical set of protocols for over 25 commonly used dynamic endocrine tests. The cornerstone of clinical endocrinology, these evidence-based protocols play an important role in clinical decision-making and are important element of billing and compliance with high quality standards. Included here are various tests for pituitary and adrenal disorders, thyroid disorders, and glucose metabolism and pancreatic disorders, presented systematically with indications, preparation, materials needed, precautions, procedure, interpretation, and caveats. Filling the gap left by a lack of national guidelines, The Cleveland Clinic Manual of Dynamic Endocrine Testing is an up-to-date practical guide for endocrinologists, nurses, and their staff, inside or outside of the US, who need to perform and interpret dynamic endocrine testing in their everyday practice, as well as medical students, residents and fellows who have interest in endocrinology.
- Contents
- Part I: Dynamic Tests in Pituitary/Adrenal Disorders -- ACTH Stimulation Test for Adrenal Insufficiency with Total Cortisol Levels -- ACTH Stimulation Test for Adrenal Insufficiency with Free Cortisol Levels -- ACTH Stimulation Test for Late Onset (Non-classic) 21-Hydroxylaseá Deficiency -- Metyrapone Stimulation Test -- Two Day Low Dose Dexamethasone Suppression Test -- Combined CRH Dexamethasone Suppression Test -- Overnight Low Dose Dexamethasone Suppression Test: 1 mg -- Overnight High Dose Dexamethasone Suppression Test: 8 mg -- Ovine Corticotropin Releasing Hormone (oCRH) Stimulation Test -- Insulin Tolerance Test (ITT) -- Glucagon Stimulation Test for GHD (GST) -- GHRH-Arginine GH Stimulation Test -- Growth Hormone Suppression Test (Post-Glucose Administration) -- Clonidine Suppression Test for Pheochromocytoma -- Intravenous Saline Suppression Test for Evaluation of Primary Aldosteronism -- Oral Sodium Loading Test -- Captopril Challenge Test -- Water Deprivation Test for DI -- Part II: Dynamic Tests in Thyroid Disorders -- Thyroid Cancer Follow-up: Withdrawal Protocol -- Thyroid Cancer Follow-up: Thyrogen Injection with No Scan -- Thyroid Cancer Follow-up: Thyrogen Injection with Scan with/without Treatment -- Levothyroxine Absorption Test -- Part III: Dynamic Tests in Glucose Metabolism/Pancreas Disorders -- Seventy-two Hour Fast for Insulinoma -- Glucagon Stimulation to Test Beta Cell Reserve -- Mixed Meal Hypoglycemia Test -- Secretin Stimulation Test for Gastrinoma -- Part IV: Invasive Dynamic Endocrine Testing -- Inferior Petrosal Sinus Sampling -- Adrenal Venous Sampling.
- Format
- e-Book
- Location
- Online
Clinical psychopharmacology : a practical approach
https://libcat.nshealth.ca/en/permalink/provcat31339
Humberto Marin, Javier I Escóbar.
--Hackensack, NJ:
World Scientific Pub. Co
, c2013.
- Available Online
- View e-Book
- Location
- Online
This book aims to provide comprehensive, up-to-date information on psychotropic drugs and inform clinical decisions for the treatment of mental disorders using a problem-solving approach. In order to accomplish these goals, the book has three central characteristics: it is evidence-based; it compares each individual drug with others in the same class and also those used for the same indications rather than describing them separately; it steadily draws practical conclusions and makes recommendat…
- Available Online
- View e-Book
- Author
- Marin, Humberto
- Other Authors
- Escóbar, Javier I
- Responsibility
- Humberto Marin, Javier I Escóbar
- Place of Publication
- Hackensack, NJ
- Publisher
- World Scientific Pub. Co
- Date of Publication
- c2013
- Physical Description
- 1 online resource (286 p.)
- ISBN
- 9789814343664
- Subjects (MeSH)
- Mental Disorders - drug therapy
- Psychopharmacology
- Psychotropic Drugs
- Abstract
- This book aims to provide comprehensive, up-to-date information on psychotropic drugs and inform clinical decisions for the treatment of mental disorders using a problem-solving approach. In order to accomplish these goals, the book has three central characteristics: it is evidence-based; it compares each individual drug with others in the same class and also those used for the same indications rather than describing them separately; it steadily draws practical conclusions and makes recommendations about how to select and use medications in the treatment of specific mental disorders. More than a textbook, it is meant to serve as a practical tool for professionals working in the mental health field.
- Contents
- Ch. 1. Absorption, transformation, and elimination of psychotropic medications. -- ch. 2. Neurotransmitters, receptors, and transporters. 2.1. Main types of receptors in the brain. 2.2. Neurotransmitters. 2.3. Neurotransmitter reuptake transporters -- ch. 3. Antipsychotics: a general view of therapeutic and adverse effects. 3.1. Classic antipsychotics. 3.2. New antipsychotics. 3.3. Are the new antipsychotics clinically different from the old ones? 3.4. Current concepts regarding antipsychotic action and the D[symbol] receptor. 3.5. Comparison between typical and atypical antipsychotics. 3.6. Metabolic side effects of antipsychotic drugs. 3.7. Extrapyramidal symptoms of antipsychotics. 3.8. Neuroleptic malignant syndrome. 3.9. Catatonia. 3.10. Antipsychotic-induced hyperprolactinemia. 3.11. Sexual side effects of antipsychotics. 3.12. Antihistamine adverse effects of antipsychotics. 3.13. Anticholinergic adverse effects of antipsychotics: cognitive and peripheral. 3.14. Antipsychotics and the risk of seizures. 3.15. Vascular side effects of antipsychotics. 3.16. Antipsychotics and the risk of malignant arrythmia and sudden cardiac death. 3.17. Antipsychotics and increased morbidity and mortality in patients with dementia. 3.18. Antipsychotics and suicide. 3.19. Antipsychotics and the risk of cancer -- ch. 4. Description of individual antipsychotics. 4.1. Typical antipsychotics. 4.2. Atypical antipsychotics -- ch. 5. Treatment of schizophrenia with antipsychotic medications. 5.1. Choice of an antipsychotic for the initial treatment of schizophrenia. 5.2. Dosing in the initial antipsychotic treatment of schizophrenia. 5.3. How long does it take to respond to an antipsychotic? 5.4. Monitoring antipsychotic treatment. 5.5. Maintenance of antipsychotic treatment of schizophrenia. 5.6. Combination of antipsychotic drugs in schizophrenia ("polypharmacy"). 5.7. Pharmacological management of treatment-resistant schizophrenia. 5.8. Use of long-acting injectable antipsychotics in schizophrenia -- ch. 6. Antidepressants: selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. 6.1. Introduction. 6.2. Pharmacodynamics of SSRIs and SNRIs (receptor affinity). 6.3. Pharmacokinetics of SSRIs and SNRIs. 6.4. Use of SSRIs in mental disorders. 6.5. Use of SNRIs in mental disorders. 6.6. Dosing of SSRIs and SNRIs. 6.7. Adverse effects of SSRIs and SNRIs. 6.8. Discontinuation syndrome with SSRIs and SNRIs. 6.9. Toxicity of SSRIs and SNRIs and serotonin syndrome. 6.10. Precautions with SSRIs and SNRIs. 6.11. Use of SSRIs and SNRIs during pregnancy and lactation -- ch. 7. Bupropion. 7.1. Introduction. 7.2. Pharmacology. 7.3. Approved indications and other possible uses. 7.4. Dosing and available forms of bupropion. 7.5. Side effects and adverse reactions. 7.6. Contraindications, warnings, and precautions. 7.7. Use of bupropion during pregnancy -- Ch. 8. Mirtazapine, trazodone, and nefazodone. 8.1. Mirtazapine. 8.2. Trazodone. 8.3. Nefazodone -- ch. 9. Monoamine oxidase inhibitors and tricyclic antidepressants. 9.1. Monoamine oxidase inhibitors. 9.2. Tricyclic antidepressants -- ch. 10. Individualized treatment of depression. 10.1. Patient factors to consider. 10.2. Second-generation antidepressants: doses and duration. 10.3. Hypnotics and other symptom-specific medications. 10.4. Partial response to antidepressant treatment: what to do? 10.5. No response to initial antidepressant treatment: what to do? 10.6. What about adding atypical antipsychotics in the initial treatment of depression? 10.7. Other non-antidepressant drugs recently tried in depression. 10.8. Once the patient gets better, how to stop antidepressant treatment? -- ch. 11. Benzodiazepines, buspirone, and miscellaneous medications used in anxiety disorders. 11.1. Benzodiazepines. 11.2. Buspirone. 11.3. Antiepileptic drugs. 11.4. Antihistamines. 11.5. Prazosin for nightmares in post-traumatic stress disorder. 11.6. Do antipsychotics have a role in anxiety? 11.7. Beta-blockers -- ch. 12. Medication treatment of anxiety disorders. General considerations prior to starting drug treatment. Other considerations. 12.1. Approved and potential uses of antidepressants and other medications. 12.2. Drug treatment of individual anxiety disorders -- ch. 13. Medications used in the treatment of mania. 13.1. Lithium. 13.2. Antipsychotics. 13.3. Carbamazepine. 13.4. Oxcarbazepine. 13.5. Valproic acid (divalproex, valproate). 13.6. Tamoxifen -- ch. 14. Medications used in bipolar depression, mixed states, and rapid cycling. 14.1. Electroconvulsive therapy. 14.2. Lithium. 14.3. Quetiapine. 14.4. Lamotrigine. 14.5. Valproate. 14.6. Antidepressants. 14.7. Ketamine in bipolar and treatment-resistant depression. 14.8. Pharmacological treatment of mixed states and rapid cycling bipolar disorder -- ch. 15. Medications used in the treatment of insomnia. 15.1. General rules. 15.2. Antihistamines as hypnotics. 15.3. Sedating antidepressants (trazodone and mirtazapine). 15.4. Melatonin receptor agonists. 15.5. GABA receptor agonists -- ch. 16. Medications used in the treatment of attention disorders. 16.1. Stimulant medications (psychostimulants). 16.2. Atomoxetine. 16.3. Bupropion. 16.4. Modafinil. 16.5. [symbol]-adrenergic agonists (guanfacine and clonidine) -- ch. 17. Medications used in the treatment of dementia. 17.1. Side effects. 17.2. Pharmacokinetics. 17.3. Pointers for clinical use -- ch. 18. Medications used in smoking cessation and alcohol use disorders. 18.1. Medications used in the treatment of nicotine dependence (smoking cessation). 18.2. Medications used in the treatment of alcohol use disorders -- ch. 19. Drug-drug interactions. 19.1. Pharmacokinetic drug-drug interactions. 19.2. Pharmacodynamic DDIs involving psychotropic drugs. 19.3. Drug-drug Interactions due to cumulative toxicity. 19.4. Drug-drug interactions related to food supplements and substances of abuse.
- Format
- e-Book
- Location
- Online
Common Surgical Diseases : An Algorithmic Approach to Problem Solving
https://libcat.nshealth.ca/en/permalink/provcat38959
Theodore J. Saclarides, Jonathan A. Myers, Keith W. Millikan, editors.
(3rd ed.)
--New York, NY:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
Written by leaders in the field, the third edition of Common Surgical Diseases: An Algorithmic Approach to Problem Solving, provides surgical residents and medical students with a current, concise and algorithmic approach to frequently encountered clinical challenges. Each chapter details every common surgical disease in the form of a succinct text coupled with step-by-step algorithm. It also walks the reader through the evaluation, diagnosis, treatment and follow-up of the most common surgical…
- Available Online
- View e-Book
- Other Authors
- Saclarides, Theodore J
- Myers, Jonathan A
- Millikan, Keith W
- Responsibility
- Theodore J. Saclarides, Jonathan A. Myers, Keith W. Millikan, editors
- Edition
- 3rd ed.
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xxi, 372 p. : 95 illus., 4 illus. in color)
- ISBN
- 9781493915651
- 9781493915644 (print ed.)
- Subjects (MeSH)
- Postoperative Complications
- Risk Assessment
- Surgical Procedures, Operative
- Abstract
- Written by leaders in the field, the third edition of Common Surgical Diseases: An Algorithmic Approach to Problem Solving, provides surgical residents and medical students with a current, concise and algorithmic approach to frequently encountered clinical challenges. Each chapter details every common surgical disease in the form of a succinct text coupled with step-by-step algorithm. It also walks the reader through the evaluation, diagnosis, treatment and follow-up of the most common surgical problems. Thoroughly updated and revised, the third edition focuses on problems most frequently encountered by general surgeons and their residents and students. More factual information is included in the form of charts and tables for quick and easy reference. The section on critical care is updated and expanded. The section on pre-operative considerations has new chapters on how to best manage patient's medications before surgery (anticoagulants, anti-platelet drugs) and prophylaxis of deep venous thrombosis. Other new chapters include access for hemodialysis, adrenal incidentaloma, esophageal cancer, pancreatic cancer, management of abdominal wall defects, hyperglycemia, necrotizing soft tissue infections and SIRS/sepsis. Especially pertinent in todays' medical environment is an understanding of the genetic component of certain cancers and chapters are devoted to screening and treating patients with genetic predispositions to colorectal and breast cancer.
- Contents
- Part I. General Preoperative Considerations -- Cardiac Clearance for Non-Cardiac Surgery -- Preoperative Evaluation of Bleeding -- Managing Patient's Medications (Diabetes, Beta Blockers, NSAIDS, Anticoagulants) -- The Carotid Bruit -- DVT Prophylaxis -- Part II. Trauma -- Initial Trauma Assessment and Resuscitation -- Head Trauma -- Management of the Difficult Airway -- Penetrating Neck Trauma -- Penetrating Chest Trauma -- Penetrating Abdominal Trauma -- Blunt Abdominal Trauma -- Pelvic Fractures -- Traumatic Hematuria -- Extremity Fractures -- Burns -- Part III. Vascular Problems -- Chronic Lower Extremity Ischemia -- Algorithmic Approach to the Acute Cold Leg -- Myocardial Infarction -- Abdominal Aortic Aneurysm -- Dialysis Access -- Part IV. Endocrine Disorders -- Thyroid Nodules and Malignancy -- Cushing's Syndrome -- Hyperthyroidism -- Hypercalcemia -- Insulinoma -- Gastrinoma -- Surgical Hypertension: Evaluation and Treatment -- Incidentalomas -- Part V. Abdomen -- Upper Gastrointestinal Hemorrhage -- Dysphagia -- Esophageal Cancer -- Gastroesophageal Reflux -- Acute Pancreatitis -- Chronic Pancreatitis -- Small Bowel Obstruction -- Ulcer Disease and Helicobacter Pylori -- Ischemic Bowel -- Crohn's Disease -- Ulcerative Colitis -- Acute Appendicitis -- Diverticulitis -- Large Bowel Obstruction -- Colon Cancer -- Lower Gastrointestinal Hemorrhage -- Genetic Predisposition to Colorectal Cancer -- Rectal Cancer -- Anal Cancer -- Anorectal Pain- Rectal Bleeding -- Rectal Bleeding -- Jaundice -- Liver Mass -- Portal Hypertension -- Carcinoid Disease -- Inguinal Hernia -- Abdominal Wall Defects -- Indications for Renal Transplantation -- Indications for Liver Transplantation and Pre-transplant Evaluation -- Part VI. Surgical Oncology -- Palpable Breast Mass -- Abnormal Mammogram -- Invasive Breast Cancer -- Nipple Discharge -- Ductal Carcinoma in Situ -- Genetic Predisposition to Breast Cancer -- Melanoma -- Solitary Pulmonary Nodules -- Evaluation of the Suspicious Neck Mass -- Part VII. Pediatrics -- Hypertrophic Pyloric Stenosis -- Jaundice in the Pediatric Patient -- Pediatric Abdominal Masses -- Esophageal Atresia/Tracheoesophageal Fistula -- Intussusception -- Hirschsprung's Disease -- Necrotizing Enterocolitis -- Part VIII. Urology -- Hematuria -- Testicular Mass -- Painful Scrotum -- Part IX. Gynecology -- Acute Gynecologic Pelvic Pain -- Evaluation and Management of Adnexal Masses -- Pelvic Inflammatory Diseases -- Part X. Critical Care -- Postoperative Glucose Management -- Oliguria -- Postoperative Fever -- Postoperative Chest Pain -- Necrotizing Soft Tissue Infections -- Systemic Inflammatory Response Syndrome (SIRS) and Sepsis.
- Format
- e-Book
- Location
- Online
Crohn's Disease and Ulcerative Colitis : From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
https://libcat.nshealth.ca/en/permalink/provcat30928
Daniel C. Baumgart, editor.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
The conditions of Crohn's disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient's quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are …
- Available Online
- View e-Book
- Other Authors
- Baumgart, Daniel C
- Responsibility
- Daniel C. Baumgart, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xviii, 754 p. : 151 ill., 116 ill. in color)
- ISBN
- 9781461409984
- Subjects (MeSH)
- Colitis, Ulcerative
- Crohn Disease
- Subjects (LCSH)
- Gastroenterology
- Abstract
- The conditions of Crohn's disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient's quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are sometimes complex and associated with important risks requiring a deeper understanding of their molecular principles from clinicians. Crohn's Disease and Ulcerative Colitis serves as a unique combined resource for physicians and scientists addressing the needs of both groups. It will stimulate exchange and collaboration and shorten the path between discovery and application of new knowledge and also help clinicians understand new therapeutic concepts from their origins. This volume provides an introduction to mucosal immunology which forms the basis of modern immunotherapy. It also serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy as well as conventional and complex immunomodulatory principles. Each chapter is written by experts in their field and includes the most up to date information. Crohn's Disease and Ulcerative Colitis will be of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis and related autoimmune disorders.
- Contents
- The genetics of inflammatory bowel disease -- Environmental factors in the epidemiology of inflammatory bowel disease -- The intestinal immune system in health -- Understanding the epithelial barrier in inflammatory bowel disease -- Intestinal microbiology and ecology in inflammatory bowel disease -- Microbial recognition and pathogen-associated molecular pattern (PAMP) receptors in inflammatory bowel disease -- Inflammasomes in inflammatory bowel disease -- Antimicrobial peptides in inflammatory bowel disease -- Vascular responses to intestinal inflammation in inflammatory bowel disease -- Immunobiology of dendritic cells in inflammatory bowel disease -- Immunobiology of T-Cells in inflammatory bowel disease -- Immunobiology of B-Cells in inflammatory bowel disease -- Immunobiology of monocytes and macrophages in inflammatory bowel disease -- Immunobiology of epithelial cells in inflammatory bowel disease -- The Th1, Th2 and Th17 paradigm in inflammatory bowel disease -- Preclinical studies using mouse models of inflammatory bowel disease -- Enhanced endoscopy in inflammatory bowel disease -- MRI in Inflammatory Bowel Disease -- CT in inflammatory bowel disease -- Ultrasound in inflammatory bowel disease -- Laboratory evaluation including novel diagnostic markers of inflammatory bowel disease -- Histology and pathology of inflammatory bowel disease -- Activity indices based assessment of disease activity in inflammatory bowel disease -- Endoscopic assessment of disease activity and mucosal healing in inflammatory bowel disease -- Evaluation of quality of life in inflammatory bowel disease -- The natural history of inflammatory bowel disease -- Conventional medical management of Crohn's disease: sulfasalazine -- Conventional medical management of Crohn's disease: corticosteroids -- Conventional medical management of Crohn's disease: azathioprine and 6-mercaptopurine -- Conventional medical management of Crohn's Disease: Methotrexate -- Biologic Treatment of Crohn's Disease: Adalimumab -- Biologic Treatment of Crohn's Disease: Certolizumab -- Biologic Therapy of Crohn's disease: Infliximab -- Biologic Treatment of Crohn's Disease: briakinumab and ustekinumab -- Biologic Treatment of Crohn's Disease: natalizumab, vedolizumab and edrolizumab (rHUMab beta 7) -- Conventional medical management of ulcerative colitis: sulfasalazine and 5-aminosalicylates -- Conventional medical management of ulcerative colitis: corticosteroids -- Conventional medical management of ulcerative colitis: azathioprinetherapy: Azathioprine -- Conventional medical management of ulcerative colitis: cyclosporine -- Conventional medical management of ulcerative colitis: tacrolimus -- Biologic therapy of ulcerative colitis: infliximab and adalimumab -- Biologic therapy of ulcerative colitis: natalizumab, vedolizumab, edrolizumab (rHUMab beta 7) -- Probiotics, prebiotics, and antibiotics in medical management inflammatory bowel disease -- Step-Up vs. Top-Down Approach in medical management of inflammatory bowel disease -- Surgical management of Crohn's disease and ulcerative colitis -- Extraintestinal manifestations of inflammatory bowel disease: autoimmune hepatitis -- Extraintestinal manifestations of inflammatory bowel disease: primary sclerosing cholangitis (PSC) -- Extraintestinal manifestations of inflammatory bowel disease: autoimmune pancreatitis and other IgG4-related conditions -- Extraintestinal manifestations of inflammatory bowel disease: cutaneous and oral manifestations of inflammatory bowel disease -- Extraintestinal manifestations of inflammatory bowel disease: arthritis, arthropathy and osteoporosis -- Nutrition in inflammatory bowel disease -- Fertility and pregnancy in inflammatory bowel disease -- Pediatric aspects in inflammatory bowel disease -- Management and prevention of infectious diseases in inflammatory bowel disease patients -- Diagnosis and management of colorectal neoplasia in patients with inflammatory bowel disease -- How to identify high risk patients in inflammatory bowel disease? -- Patient perspective on inflammatory bowel disease -- Patient resources in inflammatory bowel disease.
- Format
- e-Book
- Location
- Online
Crohn's Disease and Ulcerative Colitis : From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
https://libcat.nshealth.ca/en/permalink/provcat41327
Daniel C. Baumgart, editor.
(Second edition)
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, …
- Available Online
- View e-Book
- Other Authors
- Baumgart, Daniel C
- Responsibility
- Daniel C. Baumgart, editor
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xx, 695 pages) : 204 illus., 144 illus. in color
- ISBN
- 9783319337036
- 9783319337012 (print ed.)
- Subjects (MeSH)
- Colitis, Ulcerative
- Crohn Disease
- Abstract
- This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis, and related autoimmune disorders.
- Contents
- Part I. Epidemiology -- Environmental Factors in the Epidemiology of Inflammatory Bowel Disease -- Part II. Immunobiology -- The Immune System in Health -- Understanding the Epithelial Barrier in IBD -- Intestinal Microbiology and Ecology in Crohn's Disease and Ulcerative Colitis -- The Immune System in Inflammatory Bowel Disease: Antimicrobial Peptides -- Vascular Responses to Intestinal Inflammation -- Immunobiology of Human Dendritic Cells in Inflammatory Bowel Disease -- Immunobiology of T-cells in Inflammatory Bowel Disease -- Immunology of B-cells in Inflammatory Bowel Disease -- Immune Cells: Monocytes and Macrophages -- Immune Functions of Epithelial Cells in Inflammatory Bowel Disease -- Autophagy and Endoplasmic Reticulum Stress -- Matrix Metalloproteinases -- Paradigm of T-cell Differentiation in Irritable Bowel Disease -- Pharmacological Intervention Studies Using Mouse Models of Chronic Intestinal Inflammation -- Stem Cells and Organoids to Study Epithelial Cell Biology in Inflammatory Bowel Disease -- Part III. Diagnostic Approach -- Enhanced Endoscopy -- Magnetic Resonance Enterography -- Computed Tomography Enterography and Inflammatory Bowel Disease -- Ultrasound in Inflammatory Bowel Disease -- Laboratory Evaluation, Including Novel Diagnostic Markers -- Pathology of Inflammatory Bowel Disease -- Objective Assessment of Clinical Disease Activity -- Objective Assessment of Endoscopic Disease Activity and Mucosal Healing -- Evaluation of Quality of Life in Crohn's Disease and Ulcerative Colitis: What Is Health-Related Quality of Life? -- Evaluation of Health Economics in Inflammatory Bowel Disease -- Part IV. Therapy: Crohn’s Disease -- The Natural History of Inflammatory Bowel Disease -- Conventional Medical Management of Crohn's Disease: Sulfasalazine -- Steroid Therapy for Crohn's Disease -- Thiopurines in Crohn's Disease -- Conventional Medical Management of Crohn's Disease: Methotrexate -- Adalimumab for the Treatment of Crohn's Disease -- Biologic Therapy of Crohn's Disease: Certolizumab -- Biologic Therapy of Crohn's Disease: Infliximab -- Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment -- Biologic Therapy of Crohn's Disease: Natalizumab, Vedolizumab and anti-MadCAM -- Optimal Management of Fistulizing Crohn's Disease -- Part V. Therapy: Ulcerative Colitis -- Sulfasalazine and 5-aminosalicylates for Ulcerative Colitis -- Conventional Therapy of Ulcerative Colitis: Corticosteroids -- Medical Management of Ulcerative Colitis: Conventional Therapy: Azathioprine -- Calcineurin Inhibitors in Ulcerative Colitis -- Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab -- Biologic Therapy of Ulcerative Colitis: Adalimumab -- Biologic Therapy of Ulcerative Colitis: Golimumab -- Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab beta 7), antiMadCAM -- Probiotics, Prebiotics, and Antibiotics in Inflammatory Bowel Disease -- Biosimilars in the Treatment of Inflammatory Bowel Disease -- Step-up versus Top-down Approach in Crohn's Disease -- Leukocytapheresis Therapy of Inflammatory Bowel Diease -- Surgical Management of Crohn's Disease and Ulcerative Colitis -- Part VI. Extraintestinal Manifestations -- Extraintestinal Manifestations: Autoimmune Hepatitis -- Primary Sclerosing Cholangitis -- Autoimmune Pancreatitis and Other Organ Involvement -- Cutaneous and Oral Manifestations of Inflammatory Bowel Disease -- Arthritis, Arthropathy and Osteoporosis in Inflammatory Bowel Disease -- Part VII. Nutrition -- Nutrition in Inflammatory Bowel Disease -- Part VIII. Pregnancy, Family Planning and Pediatric Aspects -- Pregnancy and Fertility in Inflammatory Bowel Disease -- Pediatric Aspects of Inflammatory Bowel Disease -- Part IX. Surveillance and Prevention -- Management and Prevention of Infectious Diseases in Inflammatory Bowel Disease Patients -- Incidence of Cancer and Screening in Inflammatory Bowel Disease -- Inflammatory Bowel Diseases: How to Identify High Risk Patients -- Part X. Patient Perspective and Resources -- Patient Perspective on Inflammatory Bowel Disease -- Patient Resources in Inflammatory Bowel Disease.
- Format
- e-Book
- Location
- Online
The Diabetes Textbook : Clinical Principles, Patient Management and Public Health Issues
https://libcat.nshealth.ca/en/permalink/provcat44446
Joel Rodriguez-Saldana, editor.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sourc…
- Available Online
- View e-Book
- Other Authors
- Rodriguez-Saldana, Joel
- Responsibility
- Joel Rodriguez-Saldana, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xx, 1040 p.) : 212 illus., 183 illus. in color
- ISBN
- 9783030118150
- 9783030118143 (Print ed.)
- 9783030118167 (Print ed.)
- Subjects (MeSH)
- Diabetes Mellitus
- Specialty
- Diabetes Mellitus
- Abstract
- Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes.
- Contents
- Preface: A New Disease? -- Part I. Magnitude of the Problem from an Individual and Social Context -- The Dynamics of Diabetes Prevalence, Morbidity and Mortality -- Economic Costs, from Individuals to Health Systems: Evidence from a Middle Income Country -- The Ecological Approach to Self-Care in Diabetes -- Social Determinants of Health and Diabetes Outcomes -- Part II. Diagnosis, Classifications and Mechanisms of Disease -- Definition, Diagnostic Criteria, Screening, Diagnosis and Classification of Diabetes and Categories of Glucose Intolerance -- Pathophysiology of Type 1 Diabetes -- Pathophysiology of Type 2 Diabetes -- Genetic Determinants of Type 2 Diabetes -- Gene Expression Modifications in Type 2 Diabetes -- The Immune System and Inflammation in Type 2 Diabetes -- Dysfunction and Death of Pancreatic Beta Cells in Type 2 Diabetes -- Obesity in the Pathophysiology of Diabetes -- Pathogenesis of Gestational Diabetes -- Non-Alcoholic Fatty Liver in the Pathogenesis of Diabetes -- Part III. Global Experiences in Diabetes Care -- Diabetes Management in Europe -- Diabetes Management in Asia -- Diabetes Management in the United States -- Diabetes Management in Africa -- Part IV. Basic Components of Management: Patient Centeredness, Evidence-Based Medicine and Outcomes. Challenges for Implementation -- The Patient-Centered Medical Home, Primary Care and Diabetes -- Outpatient Diabetes Management and the Chronic Care Model -- Clinical Practice Guidelines for Diabetes -- Quality of Diabetes Care: Measuring Clinical Impact, Cost Effectiveness and Patient Experience of Care -- Clinical Inertia in Diabetes: The Role of Physicians -- Patient Adherence in Diabetes: Challenges, Myths and Realities -- Part V. Resources of Support for Persons with Diabetes -- Challenges and Opportunities in Diabetes Education -- Diabetes and Mental Health: From Distress to Depression -- Tools of Self-Care: Self-Monitoring of Blood Glucose and Tele-health Resources -- Continuous Glucose Monitoring and Clinical Decision Making -- Diabetes and Lifestyle Medicine -- Evidence and Implementation of Nutrition Therapy in Persons with Diabetes -- Evidence and Implementation of Physical Activity and Exercise -- Part VI. Drug Therapy -- The “Old” Oral Antidiabetics -- Incretin Therapies: Current Use and Emerging Possibilities -- Sodium Glucose Transporter Inhibitors -- Insulin in Outpatient Diabetes Management -- Insulin Pump Therapy -- Part VII. Cardiovascular Risk Factors -- Diabetes and Hypertension -- Diabetes and Atherogenic Dyslipidemia -- Diabetes and Obesity -- Diabetes and Smoking -- Part VIII.Acute Complications -- Hyperglycemic Crisis: Diabetic (ketoacidosis (DKA) -- Hypoglycemia: Diagnosis, Management and Prevention -- Inpatient Management of Diabetes and Hyperglycemia -- Diabetes and Infection -- Part IX. Chronic Complications -- Diabetes and Stroke: The Role of Glucose Regulation -- Diabetes and Peripheral Artery Disease -- Biochemical and Molecular Mechanisms of Vascular Complications in Diabetes -- Ophthalmologic Eye Disease -- Diabetes and Oral Health -- Renal Disease in Diabetes -- Peripheral Diabetic Neuropathies -- Diabetic Cardiac Autonomic Neuropathy -- Autonomic Visceral Neuropathy and Gastrointestinal Disorders -- Urologic Complications and Sexual Dysfunction -- Musculoskeletal Complications of Diabetes -- Diabetes and the Skin -- Foot Complications -- Diabetes and Cancer -- Part X. Diabetes in Special Populations -- Children and Adolescents -- Pregnancy: Pregestational and Gestational Management -- The Elderly with Diabetes -- Part XI. Diabetes Prevention -- Prevention of Type 2 Diabetes: Evidence and Challenges -- Part XII. Novel Therapeutic Approaches: Evidence-Based and Others -- Insulin Pumps and Closed Loop Systems and the Artificial Pancreas -- Unproven Therapies for Diabetes.
- Format
- e-Book
- Location
- Online
Diagnosis of Cutaneous Lymphoid Infiltrates : A Visual Approach to Differential Diagnosis and Knowledge Gaps
https://libcat.nshealth.ca/en/permalink/provcat44294
Antonio Subtil.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This volume is the first of its kind to emphasize the visual approach in the diagnosis of cutaneous lymphoid infiltrates. Written and designed in an accessible yet highly detailed format by an expert in the field, this book bridges the knowledge gaps so often found when dealing with skin lymphomas. Complete with more than two hundred high quality images and illustrations, Diagnosis of Cutaneous Lymphoid Infiltrates offers pearls and pitfalls as well as differential diagnoses. Additionally, imag…
- Available Online
- View e-Book
- Author
- Subtil, Antonio
- Responsibility
- Antonio Subtil
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xiv, 333 p.) : 277 illus. in color
- ISBN
- 9783030116545
- 9783030116521 (Print ed.)
- 9783030116538 (Print ed.)
- Subjects (MeSH)
- Diagnosis, Differential
- Lymphoid Tissue - pathology
- Lymphoma, T-Cell, Cutaneous - diagnosis
- Specialty
- Medical Oncology
- Abstract
- This volume is the first of its kind to emphasize the visual approach in the diagnosis of cutaneous lymphoid infiltrates. Written and designed in an accessible yet highly detailed format by an expert in the field, this book bridges the knowledge gaps so often found when dealing with skin lymphomas. Complete with more than two hundred high quality images and illustrations, Diagnosis of Cutaneous Lymphoid Infiltrates offers pearls and pitfalls as well as differential diagnoses. Additionally, images are explained and decoded with the use of illustrations and analogies, proving to be an invaluable resource for pathologists, dermatologists, dermatopathologists, hematopathologists, and residents and fellows in these fields. .
- Contents
- Part I. The Basics -- Clinical Pathological Correlation -- Skin Biopsy Evaluation -- Lymphocyte Morphology -- Lymphoid Follicle Morphology and Components -- Reactive Versus Neoplastic Lymphoid Follicles -- Extrafollicular Localization of Germinal Center Cells -- Part II. Histomorphologic Differential Diagnosis (DDx) -- DDx of Epidermotropism -- DDx of Ulceration -- DDx of Perifollicular Accentuation -- DDx of Eosinophil-Rich Infiltrate -- DDx of Lymphoid Follicle Formation -- DDx of Angiocentrism -- DDx of Pannicular-based Infiltrate -- DDx of Large Cell Infiltrate -- Part III. Special Techniques -- Basic Immunohistochemistry Panels -- CD8-Positive Cutaneous Infiltrates -- Differential Diagnoses of CD30 Expression -- Differential Diagnoses of CD56 -- EBV-positive Cutaneous Infiltrates -- Differential Diagnoses of BCL2-positive follicles -- Part IV. Diagnostic Entities -- Secondary Cutaneous Invovlement by Systemic/Nodal Lymphomas -- Classic Mycosis Fungoides (MF) -- Folliculotropic Mycosis Fungoides (FMF) -- Pagetoid Reticulosis -- Granulomatous Slack Skin -- Sezary Syndrome -- Primary Cutaneous CD30+ Lymphoproliferative Disorders, Primary Cutaneous Anaplastic Large Cell Lymphoma -- Primary Cutaneous CD30+ Lymphoproliferative Disorders, Lymphomatoid Papulosis -- Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferate Disorder -- Subcutaneous Panniculitis-like T-cell Lymphoma (alpha-beta) -- Cutaneous Gamma-Delta T-cell Lymphoma -- Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma -- Extranodal NK/T-cell Lymphoma, Nasal Type -- Hydroa Vacciniforme-like T-cell Lymphoproliferative Disorder -- Adult T-cell Leukemia/Lymphoma (ATLL) -- Primary Cutaneous Acral CD8+ T-cell Lymphoma (Indolent DC8+ Lymphoid Proliferation of the Ear) -- Primary Cutaneous Peripheral T-cell Lymphoma, Unspecified -- Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type -- Primary Cutaneous Diffuse Large B-cell Lymphoma, Other -- Primary Cutaneous Follicle Center Lymphoma -- Primary Cutaneous Marginal Zone B-cell Lymphoma -- Lymphomatoid Granulomatosis (LYG) -- Blastic Plasmacytoid Dendritic Cell Neoplasm -- Appendix 1. Main Immunohistochemical Stains Used in the Diagnosis of Lymphoproliferative Disorders -- Appendix 2. Genetics of Cutaneous Lymphomas -- Appendix 3. Basic Features of Cutaneous Pseudolymphomas.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
Drug Interactions in Infectious Diseases
https://libcat.nshealth.ca/en/permalink/provcat30018
Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai, editors.
(3rd ed.)
--Totowa, NJ:
Springer Science+Business Media
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Piscitelli, Stephen C
- Rodvold, Keith A
- Pai, Manjunath P
- Responsibility
- Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai, editors
- Edition
- 3rd ed.
- Place of Publication
- Totowa, NJ
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2011
- Series Title
- Infectious disease
- ISBN
- 9781617792137
- Subjects (MeSH)
- Anti-Infective Agents - pharmacology
- Anti-Infective Agents - therapeutic use
- Communicable Diseases - drug therapy
- Communicable Diseases - complications
- Drug Interactions
- Subjects (LCSH)
- Pharmacy
- Infectious diseases
- Contents
- 1. Introduction to Drug-Drug Interactions -- 2. Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- 3. Mechanisms of Drug Interactions II: Transport Proteins -- 4. Drug-Food Interactions -- 5. Interactions Between Herbs and Antiinfective Medications -- 6. Drug-Cytokine Interactions -- 7. Beta-Lactam Antibiotics -- 8. Macrolides, Azalides, and Ketolides -- 9. Quinolones -- 10. Glycopeptides, Lipopeptides, and Lipoglycopeptides -- 11. Miscellaneous Antibiotics -- 12. Drugs for Tuberculosis -- 13. Drug Interactions with Antiretrovirals for HIV Infection -- 14. Non-HIV Antiviral Agents -- 15. Antifungal Agents -- 16. Antimalarial Agents -- 17. Antiprotozoal and Anthelmintic Agents -- 18. Drug Interaction Considerations Throughout Drug Development -- 19. Probe Cocktail Studies -- 20. Design and Data Analysis in Drug Interaction Studies.
- Format
- e-Book
- Location
- Online
Drug Interactions in Infectious Diseases : Antimicrobial Drug Interactions
https://libcat.nshealth.ca/en/permalink/provcat43114
Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors.
(Fourth edition)
--Cham:
Humana Press
, c2018.
- Available Online
- View e-Book
- Location
- Online
The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Antimicrobial Drug Interactions," delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for…
- Available Online
- View e-Book
- Other Authors
- Pai, Manjunath P.
- Kiser, Jennifer J.
- Gubbins, Paul O.
- Rodvold, Keith A
- Responsibility
- Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold, editors
- Edition
- Fourth edition
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xvi, 565 p.) : 2 illus., 1 illus. in color
- Series Title
- Infectious disease
- ISBN
- 9783319724164
- 9783319724157 (print ed.)
- 9783319724171 (print ed.)
- 9783030101978 (print ed.)
- Subjects (MeSH)
- Anti-Infective Agents - pharmacology
- Anti-Infective Agents - therapeutic use
- Communicable Diseases - drug therapy
- Drug Interactions
- Specialty
- Infectious Disease Medicine
- Pharmacology
- Abstract
- The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes—"Mechanisms and Models of Drug Interactions" and "Antimicrobial Drug Interactions". This volume, "Antimicrobial Drug Interactions," delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
- Contents
- Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions in HIV: Protease and Integrase Inhibitors -- Drug Interactions in HIV: Nucleoside, Nucleotide, and Nonnucleoside Reverse Transcriptase Inhibitors and Entry Inhibitors -- Hepatitis B and Hepatitis C Antiviral Agents -- Drug Interactions of Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelminthic Agents.
- Format
- e-Book
- Location
- Online
