Ocular disease : mechanisms and management
https://libcat.nshealth.ca/en/permalink/provcat31547
[edited by] Leonard A. Levin, Daniel M. Albert.
--[Philadelphia]:
Saunders/Elsevier
, 2010.
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Ocular Disease-a newly introduced companion volume to the classic Adlers Physiology of the Eye-correlates basic science and clinical management to describe the how and why of eye disease processes and the related best management protocols. Editors Leonard A. Levin and Daniel M. Albert-two of the world's leading ophthalmic clinician-scientists-have recruited as contributors the most expert and experienced authorities available in each of the major areas of ophthalmic disease specific to ophthalm…
- Available Online
- View e-Book
- Other Authors
- Levin, Leonard A
- Albert, Daniel M
- Responsibility
- [edited by] Leonard A. Levin, Daniel M. Albert
- Place of Publication
- [Philadelphia]
- Publisher
- Saunders/Elsevier
- Date of Publication
- 2010
- Physical Description
- 1 online resource (xv, 687 p.)
- ISBN
- 9780702029837
- Subjects (MeSH)
- Eye Diseases
- Eye - physiopathology
- Subjects (LCSH)
- Ophthalmology
- Eye - Diseases
- Eye - Diseases - Treatment
- Eye Diseases
- Eye - physiopathology
- Ophtalmologie
- Œil - Maladies
- Œil - Maladies - Traitement
- Notes
- "Expert consult"--Cover
- Abstract
- Ocular Disease-a newly introduced companion volume to the classic Adlers Physiology of the Eye-correlates basic science and clinical management to describe the how and why of eye disease processes and the related best management protocols. Editors Leonard A. Levin and Daniel M. Albert-two of the world's leading ophthalmic clinician-scientists-have recruited as contributors the most expert and experienced authorities available in each of the major areas of ophthalmic disease specific to ophthalmology: retina, cornea, cataract, glaucoma, uveitis, and more. The concise chapter structure features liberal use of color-with 330 full-color line artworks, call-out boxes, summaries, and schematics for easy navigation and understanding. In print and online at expertconsult.com, this comprehensive resource provides you with a better and more practical understanding of the science behind eye disease and its relation to treatment. Includes access to the fully searchable text online at expertconsult.com, along with images and references. Covers all areas of disease in ophthalmology including retina, cornea, cataract, glaucoma, and uveitis for the comprehensive information you need for managing clinical cases. Presents a unique and pragmatic blend of necessary basic science and clinical application to serve as a clinical guide to understanding the cause and rational management of ocular disease
- Contents
- Loss of corneal transparency / Russell L McCally -- Abnormalities of corneal wound healing / Audrey M Bernstein -- Wound healing after laser in situ keratomileusis and photorefractive keratectomy / Fabricio Witzel de Medeiros and Steven E Wilson -- Genetics and mechanisms of hereditary corneal dystrophies / John D Gottsch -- Fuchs' endothelial corneal dystrophy / Vinay Gutti, David S Bardenstein, Sudha Iyengar, and Jonathan H Lass -- Keratoconus / M Cristina Kenney and Ronald N Gaster -- Infectious keratitis / Michael S Gilmore, Susan R Heimer, and Ai Yamada -- Corneal graft rejection / Daniel R Saban, Mohammad H Dastjerdi, and Reza Dana -- Corneal edema / Daniel G Dawson and Henry F Edelhauser -- Corneal angiogenesis and lymphangiogenesis / Chih-Wei Wu, David Ellenberg, and Jin-Hong Chang -- Ocular surface restoration / Julie T Daniels, Genevieve A Secker, and Alex J Shortt -- Herpetic keratitis / Pranita P Sarangi and Barry T Rouse -- Ocular allergy / Neal P Barney, Ellen B Cook, James L Stahl, and Frank M Graziano -- The lacrimal gland and dry-eye disease / Darlene A Dartt -- Immune mechanisms of dry-eye disease / Austin K Mircheff and Joel E Schechter -- Disruption of tear film and blink dynamics / Jianhua Wang and Anuj Chauhan -- Abnormalities of eyelid and tear film lipid / Gary N Foulks and Douglas Borchman -- Dry eye: abnormalities of tear film mucins / Ann-Christin Albertsmeyer and Ilene K Gipson -- Steroid-induced glaucoma / Abbot F Clark, Xinyu Zhang, and Thomas Yorio -- Biomechanical changes of the optic disc / Ian A Sigal, Michael D Roberts, Michael JA Girard, Claude F Burgoyne, and J Crawford Downs -- Pigmentary dispersion syndrome and glaucoma / Michael G Anderson -- Abnormal trabecular meshwork outflow / Paul A Knepper and Beatrice YJT Yue -- Pressure-induced optic nerve damage / James C Tsai -- Exfoliation (pseudoexfoliation) syndrome / Robert Ritch and Ursula Schultzer-Schrehardt -- Angle closure glaucoma / Shamira Perera, Nishani Amerasinghe, and Tin Aung -- Central nervous system changes in glaucoma / Yeni N Yücel and Neeru Gupta -- Retinal ganglion cell death in glaucoma / Heather R Pelzel and Robert W Nickells -- Wound-healing responses to glaucoma surgery / Stelios Georgoulas, Annegret Dahlmann-Noor, Stephen Brocchini, and Peng Tee Khaw -- Blood flowchanges in glaucoma / Leopold Schmetterer and Mark Lesk -- Biochemical mechanisms of age-related cataract / David C Beebe, Ying-Bo Shui, and Nancy M Holekamp -- Posterior capsule opacification / Judith West-Mays and Heather Sheardown -- Diabetes-associated cataracts / Peter F Kador -- Steroid-induced cataract / Abbas Samadi -- Presbyopia / Jane F Koretz -- Restoration of accommodation / Stephen D McLeod and Michelle Trager Cabrera -- Intraoperative floppy iris syndrome / Amy Lin and Roger F Steinert -- Optic neuritis / John R Guy and Xiaoping Qi -- Abnormal ocular motor control / James A Sharpe and Arun Sundaram -- Idiopathic intracranial hypertension (idiopathic pseudotumor cerebri) / Deborah M Grzybowski and Martin Lubow -- Giant cell arteritis / Lynn K Gordon -- Ischemic optic neuropathy / Helen Danesh-Meyer -- Optic nerve axonal injury / Daniela Toffoli and Leonard A Levin -- Leber's hereditary optic neuropathy / Alfredo Sadun and Alice Kim -- Optic atrophy / Nathan T Tagg and Randy H Kardon -- Nystagmus / Frank Proudlock and Irene Gottlob -- Toxic optic nerve neuropathies / FT "Fritz" Fraunfelder and FW "Rick" Fraunfelder -- Uveal melanoma / Zelia MS Correa and J William Harbour -- Genetics of hereditary retinoblastoma / Alejandra G de Alba Campomanes and Joan M O'Brien -- Molecular basis of low-penetrance retinoblastoma / Katie Matatall and J William Harbour -- Vasculogenic mimicry / Robert Folberg and Andrew J Maniotis -- Treatment of choroidal melanoma / Aimee V Chappelow and Andrew P Schachat -- Sebaceous cell carcinoma / Alon Kahana, Jonathan T Pribila, Christine C Nelson, and Victor M Elner -- Neurofibromatosis / Robert Listernick and David H Gutmann -- Phthisis bulbi / Ingo Schmack, Hans E Volcker, and Hans E Grossniklaus -- Myopia / Terri L Young -- Pathogenesis of Graves' ophthalmopathy / A Reagan Schiefer and Rebecca S Bahn -- Duane syndrome / Joseph L Demer -- Amblyopia / Robert F Hess and Nigel Daw -- Strabismus / Christopher S von Bartheld, Scott A Croes, and L Alan Johnson -- Albinism / Gerald F Cox and Anne B Fulton -- Aniridia / Elias I Traboulsi -- Color vision defects / Maureen Neitz and Jay Neitz -- Acute retinal vascular occlusive disorders / Sohan Singh Hayreh -- Retinal photic injury: laboratory and clinical findings / Daniel Organisciak and Marco Zarbin -- Vascular damage in diabetic retinopathy / Timothy S Kern and Suber Huang -- Neovascularization in diabetic retinopathy / Corey B Westerfeld and Joan W Miller -- Diabetic macular edema / Pascale Massin, Michel Paques, and Jean-Antoine Pournaras --Dry age-related macular degeneration and age-related macular degeneration pathogenesis / Marco Zarbin and Janet S Sunness -- Neovascular age-related macular degeneration / David E Lederer, Scott W Cousins, and Karl G Csaky -- Inhibition of / Anthony P Adamis and Adrienne Berman -- Retinal detachment / Steven K Fisher and Geoffrey P Lewis -- Retinopathy of prematurity / Mary Elizabeth Hartnett and Cynthia A Toth -- Retinal energy metabolism / Robert A Linsenmeier -- Retinitis pigmentosa and related disorders / Eric A Pierce -- Visual prostheses and other assistive devices / Muhammad Ali Memon and Joseph F Rizzo III -- Paraneoplastic retinal degeneration / Grazyna Adamus -- Cellular repopulation of the retina / Budd AL Tucker, Michael J Young, and Henry J Klassen -- Proliferative vitreoretinopathy / Clyde Guidry -- Immunologic mechanisms of uveitis / Steven Yeh, Zhuqing Li, and Robert B Nussenblatt -- Herpesvirus retinitis / Sally S Atherton and Mei Zheng -- Sympathetic ophthalmia / Mirunalini Kumaradas and Narsing A Rao -- Scleritis / Srilakshmi M Sharma and James T Rosenbaum -- Infectious uveitis / Pooja Bhat, Allen Tony Jackson, and C Stephen Foster -- Ocular sarcoidosis / Russell N Van Gelder and Suzanne M Dintzis
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Neuroplasticity : New Biochemical Mechanisms
https://libcat.nshealth.ca/en/permalink/provcat30500
Costa e Silva, JA.
--London, England:
Springer Healthcare
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Costa e Silva, JA
- Other Authors
- Macher, JP
- Olié, JP
- Place of Publication
- London, England
- Publisher
- Springer Healthcare
- Date of Publication
- c2011
- Physical Description
- 1 online resource (70 p.)
- ISBN
- 9781908517180
- Subjects (MeSH)
- Neuronal Plasticity
- Neurobiology
- Subjects (LCSH)
- Neurology
- Format
- e-Book
- Location
- Online
Adler's physiology of the eye
https://libcat.nshealth.ca/en/permalink/provcat31646
Leonard A. Levin, Siv F.E. Nilsson, James Ver Hoeve ... [et al.].
(11th ed.)
--Edingburg:
Saunders Elsevier
, c2011.
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Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F.E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, help…
- Available Online
- View e-Book
- Other Authors
- Levin, Leonard A
- Responsibility
- Leonard A. Levin, Siv F.E. Nilsson, James Ver Hoeve ... [et al.]
- Edition
- 11th ed.
- Alternate Title
- Physiology of the eye
- Place of Publication
- Edingburg
- Publisher
- Saunders Elsevier
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xii, 795 p.)
- ISBN
- 9780323081160
- Subjects (MeSH)
- Ocular Physiological Phenomena
- Subjects (LCSH)
- Eye--Physiology
- Abstract
- Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F.E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts.
- Contents
- Focusing of an image on the retina -- Physiology of optical media -- Direction of gaze -- Nutrition of the eye -- Protection of the eye -- Photoreception -- Visual processing in the retina -- Non-perceptive vision -- Visual processing in the brain -- Visual perception -- Development and deprivation of vision.
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- e-Book
- Location
- Online
JIMD Reports : case and research reports, 2011/1
https://libcat.nshealth.ca/en/permalink/provcat28827
SSIEM.
--Berlin:
Springer ; SSIEM
, c2011.
- Available Online
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- Location
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JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Available Online
- View e-Book
- Other Authors
- Society for the Study of Inborn Errors of Metabolism
- Responsibility
- SSIEM
- Alternate Title
- Journal of inherited metabolic disorders reports
- Place of Publication
- Berlin
- Publisher
- Springer ; SSIEM
- Date of Publication
- c2011
- Physical Description
- 1 online resource (vi, 136 p.)
- Series Vol.
- v. 1
- Series Title
- JIMD reports
- ISBN
- 9783642177088 (e-ISBN)
- 9783642177071
- ISSN
- 2192-8312 (electronic)
- Subjects (MeSH)
- Metabolism, Inborn Errors
- Subjects (LCSH)
- Metabolic diseases
- Abstract
- JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Format
- e-Book
- Location
- Online
Topics in Dental Biochemistry
https://libcat.nshealth.ca/en/permalink/provcat29250
by Martin Levine.
--Berlin, Heidelberg:
Springer-Verlag
, c2011.
- Available Online
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- Location
- Online
- Available Online
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- Author
- Levine, Martin
- Responsibility
- by Martin Levine
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer-Verlag
- Date of Publication
- c2011
- ISBN
- 9783540881162
- Subjects (MeSH)
- Dentistry
- Mouth Diseases - physiopathology
- Biochemical Phenomena
- Subjects (LCSH)
- Dentistry
- Biochemistry
- Format
- e-Book
- Location
- Online
Urolithiasis : Basic Science and Clinical Practice
https://libcat.nshealth.ca/en/permalink/provcat30902
Jamsheer J. Talati ... [et al.], editors.
--London:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Urolithiasis: Basic Science and Clinical Practice is a comprehensive text that assists urologists in defining the best choice of treatment for each case through a balanced presentation of underlying science, diagnostic methods and practical tips, with additional discussions on educational issues, costs and management of resources. This user-friendly practical resource is replete with full-color illustrations and radiographs, covering all aspects of stone disease, and offering perspectives from…
- Available Online
- View e-Book
- Other Authors
- Talati, Jamsheer J
- Responsibility
- Jamsheer J. Talati ... [et al.], editors
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xl, 982 p. : 365 ill., 242 ill. in color)
- ISBN
- 9781447143871
- Subjects (MeSH)
- Urolithiasis
- Urinary Calculi - therapy
- Subjects (LCSH)
- Urology
- Abstract
- Urolithiasis: Basic Science and Clinical Practice is a comprehensive text that assists urologists in defining the best choice of treatment for each case through a balanced presentation of underlying science, diagnostic methods and practical tips, with additional discussions on educational issues, costs and management of resources. This user-friendly practical resource is replete with full-color illustrations and radiographs, covering all aspects of stone disease, and offering perspectives from Europe, the Americas, China, South Asia, Africa, and Australia. Topics include the biochemical and physiological basis of stone formation, treatment options, complications, assessment of techniques and technologies available, and guidelines on the prevention of stone recurrence. Urolithiasis: Basic Science and Clinical Practice is the definitive text on stone disease and is a must read for young consultants starting a new practice, and urologists in residence and training.
- Contents
- Part I. Epidemiology -- 1. Epidemiology of Kidney Stones in the European Union -- 2. Epidemiology of Stone Disease in North America -- 3. Epidemiology of Stone Disease in Pakistan -- 4. Epidemiology of Stone Disease in Northern India -- 5. Epidemiology of Stone Disease in Kerala, South India -- 6. Epidemiology of Stone Disease in China -- 7. Epidemiology of Stone Disease in South America -- 8. Epidemiology: South Africa and Sub-Saharan Africa -- 9. Epidemiology of Stone Disease in Australia -- 10. Epidemiology of Stone Disease in Saudi Arabia with an Overview of the Regional Differences -- 11. Epidemiology of Stone Disease in Iran -- 12. Epidemiology of Stone Disease Over a 40-Year Period in Japan -- 13. Epidemiology of Stone Disease in the Russian Federation and Post-Soviet Era -- 14. Renal Stone Disease in Different Racial Groups -- Part II. Etiology -- 15. Stone Composition and Morphology: A Window on Etiology -- 16. The Genetics of Kidney Stones -- 17. Familial Clustering of Stone Disease -- 18. Uric Acid Nephrolithiasis: Basic and Clinical Aspects -- 19. Oxalate and Urolithiasis -- 20. Anti-Inflammatory Proteins in Kidney Stone Matrix -- 21. Physiology of Renal Handling of Citrate -- 22. Urinary Citrate and Stone Disease -- 23. Renal Tubular Acidosis and Stone Formation -- 24. Nephrolithiasis and its Interrelationship with Vitamin D, Parathyroid Hormone, and Calcium -- 25. Current Understanding of the Role of Randall's Plaque -- 26. Melamine-Associated Urinary Stone -- 27. Trace Elements in Urolithiasis -- 28. Infection Stones -- 29. Epidemiological and Etiological Considerations -- Part III. Diagnosis -- 30. Diagnosis of Urinary Tract Stones: An Overview -- 31. Diagnosis and Differential Diagnosis of Urinary Tract Stone Disease in Emergency Settings -- 32. The Utilization of Ultrasound in the Diagnosis of Urolithiasis -- 33. The Role of Radiological Imaging -- 34. Radiation Exposure in Uroradiology -- 35. The Use of Low Dose CT Scanning -- 36. The Physics of Ultrasound and X-rays: A Primer for Urologists -- Part IV. Technology and Innovation -- 37. The Stone Surgeon/Lithotomists' Armamentarium: Today and Tomorrow -- 38. Physics and Technique of Shock Wave Lithotripsy (SWL) -- 39. Laser Lithotripsy Physics -- 40. Bioeffects of Shock Wave Lithotripsy -- 41. History and Development of the Ureteroscope: What Does the Future Hold? -- 42. The Operating Room Technicians' and Nurses' Roles in Urologic Surgery -- 43. Innovation in Stone Disease -- Part V. Management Strategies -- 44. The Management of a Patient with an Acute Stone Problem -- 45. Open Surgery: Current Status and Techniques -- 46. Shock Wave Lithotripsy: Present Indications and Future Prospects -- 47. What You Should Know about Extracorporeal Shock Wave Lithotripsy and How You Can Improve Your Performance -- 48. Examples of Clinical Problems that Might Be Encountered in Patients Treated with Extracorporeal Shockwave Lithotripsy -- 49. SWL of Renal and Ureteral Stones: The Chinese Experience -- 50. Retrograde Intrarenal Surgery (RIRS) -- 51. Percutaneous Nephrolithotomy (PCNL) -- 52. Tubeless Percutaneous Nephrolithotomy -- 53. Minimally Invasive Percutaneous Nephrolithotomy: The Chinese Approach -- 54. Percutaneous Nephrostomy, Antegrade Stent Placement, and Radiological Control of Post- PCNL Bleeding -- 55. Management Strategies for Staghorn Stones -- 56. Ureteral Stone Management: An Overview -- 57. Ureteroscopy for Ureteric Stones -- 58. Tricks for Successful Ureteroscopy -- 59. Lasers in Stone Disease -- 60. Ureteric Stents: Their Use and Abuse -- 61. Ureteric Stenting: Tips and Tricks -- 62. Transperitoneal Laparoscopic and Retroperitoneoscopic Stone Treatment -- 63. Role of Robotic-Assisted Surgery in the Management of Urolithiasis -- 64. Management of Urinary Bladder Calculi -- 65. Current Status of Medical Expulsion Therapy for Urinary Calculi -- 66. Dissolution of Stones by Oral and Irrigative Therapy -- 67. Traditional Chinese Medicine for Treatment of Urinary Stones -- 68. Patient Safety and the Importance of Informed Consent -- 69. Anesthesia and Pain Relief for Procedures Performed to Manage Urolithiasis -- Part VI. Management of Stones under Special Circumstances -- 70. Shock Wave Lithotripsy, Endourological Intervention, and Hemostatic Defects -- 71. Cardiac Rhythm Management Devices -- 72. Stone Disease in Pregnancy -- 73. Minimally Invasive Treatment of Calculi in Renal Anomalies -- 74. Kidney Stones and Chronic Kidney Disease -- 75. Calculus Renal Failure in Pakistan -- 76. Urolithiasis in Renal Transplant Donors and Recipients -- 77. Primary Hyperoxaluria: The Role and Timing of Liver and Kidney Transplantation -- Part VII. Pediatric Urolithiasis -- 78. Metabolic Stone Disease in Children -- 79. Pediatric Urinary Stone Disease in China -- 80. Patient Evaluation and Comparison of Stone-Removing Strategies in Pediatric Patients with Urinary Tract Stones -- 81. Pediatric Vesicle Stone -- 82. Shock Wave Lithotripsy for Renal Stone in Children -- 83. Endourological Approaches to Renal and Ureteric Calculi in Children -- Part VIII. Prevention of Recurrence -- 84. Biochemical Risk Evaluation in Patients with Urolithiasis -- 85. Application of Physical Methods to Kidney Stones and Randall's Plaque Characterization -- 86. General and Specific Dietary Advice for the Prevention of Stone Recurrence -- 87. Overview of Stone Prevention Strategies in China -- 88. Management of Hypercalciuria and Oxalates in the Prevention of Stone Recurrence -- 89. Citrate Therapy for Calcium and Uric Acid Stones -- 90. The Importance of Water and Other Fluids in the Prevention of Stone Recurrence -- 91. Orthophospates -- 92. Management of Cystinuria -- 93. The Detection and Management of Primary Hyperparathyroidism in Patients with Urolithiasis -- 94. Normocalcemic Hyperparathyroidism: An Illustrative Case Scenario -- 95. How to Perform a Successful Exploration of the Neck for Primary Hyperparathyroidism -- Part IX. Education, Training, Assessment, and Development -- 96. Professional Development and Competence of Physicians -- 97. Assessment in Post-Graduate Training -- 98. Assessment of Competence -- 99. Modern Concepts on Cognito-Psychomotor Skill Development -- 100. Integration of Competences -- 101. Education and Training of an Academic Urologic Surgeon -- 102. Advanced Training of a Practicing Urologist in Stone Disease Management -- 103. Across Semantic Turfs: The Need for Broader Education -- 104. Stimulating Research and Innovation in Residents -- Part X. Equitable Management of Stone Disease -- 105. Bringing Sophisticated High Technological Surgical Care to the Rural Masses: What Is India Doing? -- 106. Bringing Highly Technological Urolithiasis Care to a Billion People: What Is China Doing? -- 107. Lithotriptor Sharing -- 108. Choosing and Purchasing Expensive Medical Equipment: A Hospital Perspective -- 109. Comparative Costs of Various Treatment Strategies and Preventive Measures -- 110. Financial Options for Purchase, Lease, and Hire of Lithotriptors -- 111. The Engagement of Philanthropy -- 112. The Impact on Health Care of the Recent Global Epidemiological Trends in Urolithiasis -- 113. Societal Changes and the Etiology of Stone Disease -- Part XI. Case Scenarios -- 114. Case Scenarios and Interesting Images in Urolithiasis -- Part XII. Epilogue.
- Format
- e-Book
- Location
- Online
Diabetes & C-Peptide : Scientific and Clinical Aspects
https://libcat.nshealth.ca/en/permalink/provcat31009
Anders A.F. Sima, editor.
--New York, NY:
Humana Press
, c2012.
- Available Online
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- Location
- Online
In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, includ…
- Available Online
- View e-Book
- Other Authors
- Sima, Anders A.F
- Responsibility
- Anders A.F. Sima, editor
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xiii, 169 p. : 63 ill., 35 ill. in color)
- Series Title
- Contemporary diabetes
- ISBN
- 9781617793912
- Subjects (MeSH)
- C-Peptide - physiology
- C-Peptide - therapeutic use
- Diabetes Complications - prevention & control
- Diabetes Mellitus, Type 1 - drug therapy
- Subjects (LCSH)
- Diabetes
- Endocrinology
- Biochemistry
- Abstract
- In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.
- Contents
- C-peptide and Insulin: A Happy Marriage -- Peptide Interactions of Proinsulin C-peptide -- The Effect of Combined C-peptide and Zinc on Cellular Function -- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy -- Role of C-Peptide in the Regulation of Microvascular Blood Flow -- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy? -- Renoprotective Effects of C-Peptide in Type I Diabetes -- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy -- C-peptide and Type 1 Diabetic Encephalopathy -- C-peptide: a New Molecule with Anti-Inflammatory Properties -- C-peptide: Connecting Diabetes with Macrovascular Complications -- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes -- Proatherogenic Effects of C-Peptide -- Conclusions and Future Outlook.
- Format
- e-Book
- Location
- Online
Radionuclide and Hybrid Bone Imaging
https://libcat.nshealth.ca/en/permalink/provcat31084
Ignac Fogelman, Gopinath Gnanasegaran, Hans Wall, editors.
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
The accurate identification of pathology in the skeleton is an extremely important goal, and the great strength of the radionuclide bone scan is its ability to identify functional change before structural change occurs. Over the years, the indications for bone scan have evolved to include benign disorders as well as malignancies. Further striking developments include the emergence of PET and of new tracers that offer enhanced capabilities, such as 18F-fluoride. The most dramatic advance, howeve…
- Available Online
- View e-Book
- Other Authors
- Fogelman, Ignac
- Gnanasegaran, Gopinath
- Wall, Hans
- Responsibility
- Ignac Fogelman, Gopinath Gnanasegaran, Hans Wall, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xiv, 1046 p. : 641 ill., 294 ill. in color)
- ISBN
- 9783642024009
- Subjects (MeSH)
- Bone Diseases - diagnostic imaging
- Bone and Bones - diagnostic imaging
- Positron-Emission Tomography - methods
- Positron-Emission Tomography Computed Tomography - methods
- Subjects (LCSH)
- Nuclear medicine
- Oncology
- Orthopedics
- Abstract
- The accurate identification of pathology in the skeleton is an extremely important goal, and the great strength of the radionuclide bone scan is its ability to identify functional change before structural change occurs. Over the years, the indications for bone scan have evolved to include benign disorders as well as malignancies. Further striking developments include the emergence of PET and of new tracers that offer enhanced capabilities, such as 18F-fluoride. The most dramatic advance, however, has been the development of hybrid imaging systems that combine the strengths of different modalities. This book, written by authors with national and international reputations in the field, covers all aspects of radionuclide and hybrid bone imaging. Introductory sections present the basic science and consider the current status and limitations of conventional radiological techniques. The underlying principles of PET-CT and SPECT-CT are carefully explained, and the value of different PET and SPECT tracers, assessed. The role of single- and dual-modality approaches in the imaging of benign bone diseases and malignancies is then discussed in detail in a series of well-illustrated chapters. The pathologies addressed include metabolic bone disease, arthritis, bone and joint infections, primary bone and soft tissue tumors, and metastases from breast and prostate cancer. A further section considers the role of bone scintigraphy in the pediatric patient, and the closing chapters focus on miscellaneous subjects, including bone densitometry and radionuclide targeted therapy.
- Contents
- BONE AND BASICS SCIENCES -- Anatomy of the Skeletal System -- Physiology of Bone Formation, Remodeling, and Metabolism -- Pathophysiology of Bone Metastases -- Skeletal Tracer Kinetics: Science and Practice -- Biochemical Markers in Bone Diseases -- BONE AND CONVENTIONAL RADIOLOGY -- Basics of CT -- Basic Principles of MRI -- Radiological Imaging in Metastatic Bone Disease and Myeloma: Current Status and Limitations -- Radiological Imaging of Primary Benign and Malignant Bone Tumours -- Radiological Imaging in Trauma and Sports Injuries: Current Status and Limitations -- Radiological Imaging in Arthritis: Current Status and Limitations -- RADIONUCLIDE BONE IMAGING: SCIENCE AND PRACTICE -- Basic Principles of SPECT and PET Imaging -- Technical Challenges and Pitfalls in Hybrid Imaging -- Bone Scintigraphy: SPECT and PET Tracers -- Bone Scintigraphy: Patterns, Variants, Limitations and Artefacts -- Soft Tissue Uptake in Radionuclide Bone Scintigraphy -- BONE SCINTIGRAPHY IN BENIGN BONE DISEASE -- Bone Scintigraphy in Metabolic Bone Disease -- Bone Scintigraphy in Arthritis -- Bone Scintigraphy in Trauma and Sport Injuries -- SPECT and PET in the Assessment of Bone Infections -- BONE SCINTIGRAPHY IN BENIGN BONE DISEASE -- Nuclear Medicine in the Assessment of Painful Joint Prostheses -- Radionuclide Bone Imaging in Skeletal Tuberculosis -- Hybrid Imaging in the Management of Complex Foot and Ankle Problems -- Wrist Registration: Conventional Radionuclide and SPECT/CT Imaging -- BONE SCINTIGRAPHY IN BONE METASTASES -- Prostate Cancer: Role of Conventional Radionuclide and Hybrid Bone Imaging -- Breast Cancer: Role of Planar, SPECT and PET in Imaging Bone Metastases -- Lung, Thyroid, Renal Cancer, Myeloma and Neuroendocrine Cancers: Role of Planar, SPECT and PET in Imaging Bone Metastases -- Conventional Nuclear Medicine and Hybrid Imaging in Monitoring the Treatment of Skeletal Malignancy -- Potential Applications and Limitations of SPECT-CT in Classifying Bone Lesions in Patients with Cancer -- Primary Bone and Soft Tissue Tumours: Role of SPECT -- Primary Bone and Soft Tissue Tumours: Role of 18FDG PET -- Radioisotopes in the Treatment of Bone Metastases -- Radionuclide Bone Marrow Imaging in Cancer Patients -- PAEDIATRIC BONE SCINTIGRAPHY -- Pediatric Bone Scintigraphy: Variants and Limitations -- Paediatric Bone Scintigraphy: Benign Bone Disease -- Paediatric Bone Scintigraphy: Bone Metastases -- Hybrid Bone Imaging in Pediatrics -- BONE AND MISCELLANEOUS SCENARIOS -- Bone Densitometry: Science and Practice -- Radiosynovectomy: Science and Practice -- Radiosynoviorthesis (Radiation Synovectomy) of Knee Joint -- Common Orthopaedic Presentations -- Radiological Imaging in Infection: Current Status and Limitations.
- Format
- e-Book
- Location
- Online
JIMD reports : case and research reports, 2011/2
https://libcat.nshealth.ca/en/permalink/provcat31151
SSIEM.
--Berlin:
Springer ; SSIEM
, c2012.
- Available Online
- View e-Book
- Location
- Online
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Available Online
- View e-Book
- Other Authors
- Society for the Study of Inborn Errors of Metabolism
- Responsibility
- SSIEM
- Alternate Title
- Journal of inherited metabolic disorders reports
- Place of Publication
- Berlin
- Publisher
- Springer ; SSIEM
- Date of Publication
- c2012
- Physical Description
- 1 online resource (vii, 123 p.)
- Series Vol.
- v. 2
- Series Title
- JIMD reports
- ISBN
- 9783642247583 (e-ISBN)
- 9783642247576
- ISSN
- 2192-8312 (electronic)
- Subjects (MeSH)
- Metabolism, Inborn Errors
- Subjects (LCSH)
- Human genetics
- Metabolic diseases
- Abstract
- JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Format
- e-Book
- Location
- Online
JIMD Reports : case and research reports, 2011/3
https://libcat.nshealth.ca/en/permalink/provcat31153
SSIEM.
--Berlin:
Springer ; SSIEM
, c2012.
- Available Online
- View e-Book
- Location
- Online
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Available Online
- View e-Book
- Other Authors
- Society for the Study of Inborn Errors of Metabolism
- Responsibility
- SSIEM
- Alternate Title
- Journal of inherited metabolic disorders reports
- Place of Publication
- Berlin
- Publisher
- Springer ; SSIEM
- Date of Publication
- c2012
- Physical Description
- 1 online resource (vii, 139 p.)
- Series Vol.
- v. 3
- Series Title
- JIMD reports
- ISBN
- 9783642249365 (e-ISBN)
- 9783642249358
- ISSN
- 2192-8312 (electronic)
- Subjects (MeSH)
- Metabolism, Inborn Errors
- Subjects (LCSH)
- Human genetics
- Metabolic diseases
- Abstract
- JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Format
- e-Book
- Location
- Online
Multidisciplinary management of rectal cancer : questions and answers
https://libcat.nshealth.ca/en/permalink/provcat31155
Vincenzo Valentini, Hans-Joachim Schmoll, Cornelis J. H. Velde, editors.
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
This book seeks to promote an integrated approach among the various specialists involved in the management of rectal cancer with a view to ensuring that treatment is tailored appropriately to the individual patient. For ease of use, a question and answer format is employed. The focus is on those issues typically confronted during daily clinical practice in relation to risk factors, imaging, surgery, radiotherapy, and chemotherapy. The services of an outstanding panel of authors representative …
- Available Online
- View e-Book
- Other Authors
- Valentini, Vincenzo
- Schmoll, Hans-Joachim
- Velde, Cornelis J. H
- Responsibility
- Vincenzo Valentini, Hans-Joachim Schmoll, Cornelis J. H. Velde, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xii, 367 p. : 98 ill., 70 ill. in color)
- ISBN
- 9783642250057
- Subjects (MeSH)
- Rectal Neoplasms - therapy
- Risk Factors
- Subjects (LCSH)
- Radiology, Medical
- Radiotherapy
- Oncology
- Cancer - Surgery
- Pathology
- Abstract
- This book seeks to promote an integrated approach among the various specialists involved in the management of rectal cancer with a view to ensuring that treatment is tailored appropriately to the individual patient. For ease of use, a question and answer format is employed. The focus is on those issues typically confronted during daily clinical practice in relation to risk factors, imaging, surgery, radiotherapy, and chemotherapy. The services of an outstanding panel of authors representative of the major European oncological societies have been acquired in order to formulate the questions and provide the answers. All who need assistance in addressing concerns that arise from the need for multidisciplinary management of rectal cancer will find the book to be an ideal source of helpful information.
- Contents
- [Machine generated contents note] Part I. Introduction -- 1. What Do We Consider Cancer of the Rectum? / Cornelis J.H. van de Velde -- 2. What Is the Ongoing Recommendation in the Management of Rectal Cancer? / Cornelis J.H. van de Velde -- Part II. Q&As on Risk Factor Identification -- 3. What Prognostic Clinical Factors Must Be Considered Before Treatment? / Claus Rodel -- 4. What Are the Relevant Imaging Factors to Optimize Treatment Decisions? / Gina Brown -- 5. What Biochemical and Molecular Biological Factors Have Greater Relevance to Treatment Decisions? / Jeroen Buijsen -- 6. Do Different Populations of Rectal Cancer Exist? / Ruud van Stiphout -- Part III. Q&As on Imaging -- 7. How Can We Identify Tumour Penetration? / Gina Brown -- 8. How Can We Identify Mesorectal Fascia Involvement? / Regina G.H. Beets-Tan -- 9. How Can We Identify Nodal Involvement? / Regina G.H. Beets-Tan -- 10. How Can We Identify Pathologic Complete Responders After Radiochemotherapy? / Lucia Leccisotti -- 11. How Can We Identify Local Relapse? / Regina G.H. Beets-Tan -- Part IV. Q&As on Radiotherapy -- 12. When Should Preoperative Short-Course Radiotherapy or Long-Course Chemoradiotherapy Be Performed? / Robert Glynne-Jones -- 13. Should We Tailor the Delineation of Pelvic Structures According to Tumor Presentation? / Vincenzo Valentini -- 14. What Is the Role of IMRT and IGRT in Rectal Cancer? / Corrie A.M. Marijnen -- 15. What Are the Dose-Volume Constraints to Reduce Late Toxicity? / Krzysztof Bujko -- 16. What Is the Contribution of Intraoperative Radiotherapy (IORT) in Tailoring Local Therapy in Primary or Recurrent Rectal Cancer? / Felipe A. Calvo -- 17. What Is the Contribution of Brachytherapy in Tailoring Local Therapy? / Arthur Sun Myint -- Part V. Q&As on Chemotherapy -- 18. Should Oxaliplatin Be Added to Preoperative Chemoradiation? / Carlo Aschele -- 19. Should Biologic Targeted Agents Be Combined with Preoperative Chemoradiation in Rectal Cancer? / Eric Van Cutsem -- 20. Should Upfront Chemotherapy Precede Preoperative Chemoradiation and Surgery? / Xabier Garcia de Albeniz -- 21. How to Achieve Long-Term Survival in Patients with Metastatic Rectal Cancer? / Hans-Joachim Schmoll -- 22. Will Adjuvant Chemotherapy Improve Outcome After Preoperative Chemoradiation? / Peter Nygren -- Part VI. Q&As on Surgery -- 23. How to Evaluate the Quality of Surgery? Suggestions for Critical Reading of Surgical and Pathological Reports / Lars Pahlman -- 24. How Is Nerve-Sparing Surgery Well Performed? / Ivan Dimitrijevic -- 25. Is Laparoscopic Rectal Surgery the Gold Standard? / Laeeq Khan -- 26. Is a Diverting Stoma Always Necessary for a Low Anterior Resection of a Rectal Cancer? / Geerard L. Beets -- 27. Will Extralevator Abdominoperineal Excision Become the New Gold Standard? / Harm Rutten -- 28. Which Patients Do Benefit from Extended Resections in Case of Locally Advanced Rectal Cancer? / Harm Rutten -- 29. Can Standard Surgical Procedure Reliably Be Avoided in Major Responders After Radio(chemo)therapy? / Gianluca Rizzo -- Part VII. Q&As on Pathology -- 30. What Is the Correct Procedure for Handling the Surgical Specimen? / Nigel Scott -- 31. What Is the Prognostic Value of (y)pT and (y)pN? / Nadine Ectors -- 32. What Is the Prognostic Value of CRM Involvement? / Iris D. Nagtegaal -- 33. What Is the Prognostic Value of TRG? / Fabio M. Vecchio -- Part VIII. Q&As on Multidisciplinary Team Management -- 34. What Are the Recommendations to Ensure a Successful Multidisciplinary Team in Rectal Cancer? / Robert Glynne-Jones -- 35. What Is the Appropriate Timetable for Tailored Follow-up? / Lars Pahlman -- 36. How Should Data Be Shared and Rapid Learning Health Care Promoted? / Philippe Lambin.
- Format
- e-Book
- Location
- Online
JIMD Reports : case and research reports, 2012/1
https://libcat.nshealth.ca/en/permalink/provcat31164
SSIEM.
--Berlin:
Springer ; SSIEM
, c2012.
- Available Online
- View e-Book
- Location
- Online
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Available Online
- View e-Book
- Other Authors
- Society for the Study of Inborn Errors of Metabolism
- Responsibility
- SSIEM
- Alternate Title
- Journal of inherited metabolic disorders reports
- Place of Publication
- Berlin
- Publisher
- Springer ; SSIEM
- Date of Publication
- c2012
- Physical Description
- 1 online resource (vii, 137 p.)
- Series Vol.
- v. 4
- Series Title
- JIMD reports
- ISBN
- 9783642257520 (e-ISBN)
- 9783642257513
- ISSN
- 2192-8312 (electronic)
- Subjects (MeSH)
- Metabolism, Inborn Errors
- Subjects (LCSH)
- Human genetics
- Metabolic diseases
- Abstract
- JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Format
- e-Book
- Location
- Online
Treatment of Dry Skin Syndrome : The Art and Science of Moisturizers
https://libcat.nshealth.ca/en/permalink/provcat31172
Marie Lodén, Howard I. Maibach, editors.
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Dry skin impacts on the lives of many individuals but in most cases it can be adequately managed with current moisturizing products. Certain moisturizers, however, can themselves adversely affect the quality of life by inducing further dryness and eczema and so becoming addictive. In addition, there is a possible link between moisturizing treatments and asthma. Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the…
- Available Online
- View e-Book
- Other Authors
- Lodén, Marie
- Maibach, Howard I
- Responsibility
- Marie Lodén, Howard I. Maibach, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxxvii, 591 p. : 145 ill., 50 ill. in color)
- ISBN
- 9783642276064
- Subjects (MeSH)
- Dermatitis - drug therapy
- Emollients - therapeutic use
- Skin Care
- Skin Diseases - drug therapy
- Subjects (LCSH)
- Dermatology
- Biochemistry
- Abstract
- Dry skin impacts on the lives of many individuals but in most cases it can be adequately managed with current moisturizing products. Certain moisturizers, however, can themselves adversely affect the quality of life by inducing further dryness and eczema and so becoming addictive. In addition, there is a possible link between moisturizing treatments and asthma. Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.
- Contents
- [Machine generated contents note] Pt. I Marketplace and Treatment Aspects -- 1. Moisturizers as Cosmetics, Medicines, or Medical Device? The Regulatory Demands in the European Union / Marie Loden -- 2. Design of Claims Support for Moisturizers / Judith K. Woodford -- 3. Educational Interventions for the Management of Children with Dry Skin / Noreen Heer Nicol -- 4. Dry Skin in Childhood and the Misery of Eczema and Its Treatments / Susan Lewis-Jones -- 5. Use of Moisturizers in Patients with Atopic Dermatitis / Alexander K.C. Leung -- Pt. II Skin Essentials -- 6. Sensory Systems of Epidermal Keratinocytes / Mitsuhiro Denda -- 7. Sensitive Skin: Intrinsic and Extrinsic Contributors / Michael K. Robinson -- 8. Electron Tomography of Skin / Lars Norlen -- 9. Filaggrin Gene Defects and Dry Skin Barrier Function / Jacob P. Thyssen -- 10. Molecular Organization of the Lipid Matrix in Stratum Corneum and Its Relevance for the Protective Functions of Human Skin / Mila Boncheva -- 11. Desquamation: It Is Almost All About Proteases / Anthony V. Rawlings -- 12. Endogenous Retroviral-Like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization / Takeshi Matsui -- 13. Vernix Caseosa and Its Substitutes: Lipid Composition and Physicochemical Properties / Steven B. Hoath -- 14. Role of Tight Junctions and Aquaporins in Skin Dryness / J.M. Brandner -- 15. Biomechanics of the Barrier Function of Human Stratum Corneum / Reinhold H. Dauskardt -- Pt. III Dry Skin Disorders and Treatments -- 16. Update on Atopic Eczema with Special Focus on Dryness and the Impact of Moisturizers / Eric Simpson -- 17. Update on Hand Eczema with Special Focus on the Impact of Moisturisers / Mark Wilkinson -- 18. Update on Ichthyosis with Special Emphasis on Dryness and the Impact of Moisturizers / Johannes Wohlrab -- 19. Psoriasis and Dry Skin: The Impact of Moisturizers / Razvigor Darlenski -- 20. Update on Infant Skin with Special Focus on Dryness and the Impact of Moisturizers / Neena K. Tierney -- Pt. IV Ingredients and Treatment Effects -- 21. Composition and Development of Moisturizers / Steve Barton -- 22. Ungual Formulations: Topical Treatment of Nail Diseases / Kenneth A. Walters -- 23. Preservation of Moisturisers / D. Godfrey -- 24. Potential Allergens in Moisturizing Creams / An Goossens -- 25. Formulating Moisturizers Using Natural Raw Materials / Swarnlata Saraf -- 26. Chemical and Physical Properties of Emollients / Jari T. Alander -- 27. Polyfunctional Vehicles by the Use of Vegetable Oils / Chiara Andolfatto -- 28. Effect of Natural Moisturizing Factors on the Interaction Between Water Molecules and Keratin / Noriaki Nakagawa -- 29. Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin / David W. Koenig -- 30. Water and Minerals in the Treatment of Dryness / Lawrence Charles Parish -- 31. Hyaluronan Inside and Outside of Skin / Robert Stern -- 32. Glycerol as a Skin Barrier Influencing Humectant / Fabrice Pirot -- 33. Use of Urea in the Treatment of Dry Skin / Marie Loden -- 34. Urea and Skin: A Well-Known Molecule Revisited / Susanne Grether-Beck -- 35. Influence of Climate on the Treatment of Dry Skin with Moisturizer / E. Proksch -- 36. Emollient Therapy and Skin Barrier Function / Majella E. Lane -- 37. Skin Barrier Responses to Moisturizers: Functional and Biochemical Changes / Izabela Buraczewska-Norin -- 38. Changes in Stratum Corneum Thickness, Water Gradients and Hydration by Moisturizers / Joseph R. Kaczvinsky -- 39. Skin Moisture and Heat Transfer / Lee Berk.
- Format
- e-Book
- Location
- Online
JIMD Reports : case and research reports, 2012/3
https://libcat.nshealth.ca/en/permalink/provcat31177
SSIEM.
--Berlin:
Springer ; SSIEM
, c2012.
- Available Online
- View e-Book
- Location
- Online
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Available Online
- View e-Book
- Other Authors
- Society for the Study of Inborn Errors of Metabolism
- Responsibility
- SSIEM
- Alternate Title
- Journal of inherited metabolic disorders reports
- Place of Publication
- Berlin
- Publisher
- Springer ; SSIEM
- Date of Publication
- c2012
- Physical Description
- 1 online resource (vii, 129 p.)
- Series Vol.
- v. 6
- Series Title
- JIMD reports
- ISBN
- 9783642281297 (e-ISBN)
- 9783642281280
- ISSN
- 2192-8312 (electronic)
- Subjects (MeSH)
- Metabolism, Inborn Errors
- Subjects (LCSH)
- Human genetics
- Metabolic diseases
- Abstract
- JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Format
- e-Book
- Location
- Online
Herbal Drugs and Fingerprints : Evidence Based Herbal Drugs
https://libcat.nshealth.ca/en/permalink/provcat31211
Devi Datt Joshi.
--New Delhi:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Evidence based herbal drugs are on high-acceptance day by day due to health friendly nature compared to synthetic drugs. The active ingredients in herbal drugs are different chemical classes, e.g. alkaloids, coumarins, flavonoids, glycosides, phenols, steroids, terpenes etc., are identified at molecular level using current analytical practices, which are unique characteristic, as finger, so known as fingerprints. The fingerprints are used for assessment of quality consistency and stability by v…
- Available Online
- View e-Book
- Author
- Joshi, Devi Datt
- Responsibility
- Devi Datt Joshi
- Place of Publication
- New Delhi
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xvi, 252 p. : 108 ill., 42 ill. in color)
- ISBN
- 9788132208044
- Subjects (MeSH)
- Chemistry Techniques, Analytical - methods
- Plant Preparations - analysis
- Plant Preparations - pharmacology
- Subjects (LCSH)
- Chemistry
- Pharmacy
- Medical laboratories
- Abstract
- Evidence based herbal drugs are on high-acceptance day by day due to health friendly nature compared to synthetic drugs. The active ingredients in herbal drugs are different chemical classes, e.g. alkaloids, coumarins, flavonoids, glycosides, phenols, steroids, terpenes etc., are identified at molecular level using current analytical practices, which are unique characteristic, as finger, so known as fingerprints. The fingerprints are used for assessment of quality consistency and stability by visible observation and comparison of the standardized fingerprint pattern, have scientific potential to decipher the claims made on these drugs for authenticity and reliability of chemical constituents, with total traceability, which starts from the proper identification, season and area of collection, storage, their processing, stability during processing, and rationalizing the combinational in case of polyherbal drugs. These quality oriented documents have ample scientific logics so well accepted globally by regulatory authorities and industries, to determine intentional/ unintentional contamination, adulteration, pollutants, stability, quality, etc. parameters. Based on geo-climatic factors, a same plant species has different pharmacological properties due to different ingredients; such regional and morphological variations are identified by fingerprints, at the time of collection of the medicinal herb. The chromatographic (TLC, HPTLC, HPLC, GC,) and spectral (UV-Vis., FTIR, MNR, MS, LC-MS, GC-MS etc.) techniques have world-wide strong scientific approval as validated methods to generate the fingerprints of different chemical classes of active ingredients of herbal drugs. Presently there is a need for a book having all the fingerprinting techniques for herbal drugs at a place with theory, case studies and art to discover patentable forms. The present book is a milestone in the subject, to be utilized by Scientists, Medical Doctors, Technicians, Industrialists, Researchers, and Students both in PG and UG levels.
- Contents
- [Machine generated contents note] Pt. I. Herbal Drugs: A Review on Practices -- 1. Herbal Drugs: A Review on Practices -- Introduction -- Asian Continent and Traditional Herbal Drugs -- China and Japan -- Indian Subcontinent -- Traditional Herbal Drugs in Europe -- Traditional Herbal Drugs in America -- Traditional Herbal Drugs in Australia -- Traditional Herbal Drugs in Africa -- Industrialization of Herbal Drugs and Legislation -- Phytochemical Standardization -- Extraction of Therapeutics -- Analysis for Marker and Chromatographic Fingerprint -- Preparative HPLC to Isolate Therapeutic -- Biochemical Approach -- Reverse Pharmacology -- New Drug Development -- Synthetic Drug Development -- Modern Approach for Drug Development -- Fingerprints of Drugs: Needs and Values -- Multidisciplinary Strategy to Develop Fingerprints -- Modern Chemistry and Pharmacology -- Standardization of Fingerprints -- Pharmacokinetics of Standardized Form -- Case Study -- Commercial Manufacturing and Quality Control -- Regulatory Norms for Herbal Drugs -- Therapeutic Goods Act -- Drug Administration Law -- Ayush -- Ministry of Health and Welfare, Japan -- Ministry of Health, Saudi Arabia -- WHO Guidelines for Assessment of Herbal Drugs -- References -- Bibliography -- Pt. II. Herbal Drugs and Chromatographic Fingerprints -- 2. TLC: Herbal Drugs and Fingerprints -- Thin-Layer Chromatogram -- Preparation of TLC Plate in Laboratory -- Ready-Made TLC Plate -- Selection of Suitable Plate Size -- Spotting -- Preparation of Developing Chamber -- Chromoplate Generation -- Evaluation of TLC Plate -- Retention Factor -- Presentation of TLC Results -- Procedure to Determine R1 Value of Unknown -- Spot Development by Iodine Vapors -- Documentation of Fingerprints -- Two-Dimensional TLC -- TLC Bioautography -- Bioluminescence and TLC Analysis -- Detection of Colorless Compounds -- Combination of TLC with Other Techniques -- Criteria for Selectivity, Reproducibility and Robustness -- Special Hazards -- Troubleshooting in TLC Analysis -- Identification of Marker Compounds in Herbal Drugs -- TLC Analysis for Alkaloids -- TLC Analysis for Phenols -- TLC Analysis for Saponins -- TLC Analysis for Terpenoids -- TLC with DART-MS -- TLC Fingerprints for Batch to Batch Consistency -- References -- Bibliography -- 3. HPTLC: Herbal Drugs and Fingerprints -- Operational Summary of HPTLC -- HPTLC Pre-Coated Plates -- Detection and Visualization -- Nondestructive Techniques -- Nonreversible Reactions -- Destructive Techniques -- Common Visualizing Reagents -- Group-Specific Reaction -- Coupling of HPTLC with Spectrometry -- References -- Bibliography -- 4. HPLC: Herbal Drugs and Fingerprints -- Glance on HPLC Column -- Analytical Mobile Phases and HPLC -- Solvent Changeover in HPLC -- Buffers as Mobile Phase -- Selection of Buffer and Analytical Method Development -- Buffer Concentration -- Buffer Solubility -- Buffer and Its Impact on Detection -- Buffers as Mobile Phase in HPLC -- Detectors in HPLC: Detection, Quantification, and Fingerprints -- HPLC-UV -- HPLC-FD -- HPLC-CL -- HPLC-ECD -- HPLC Detection in Hyphenated System -- HPLC-RID -- HPLC-ELSD -- HPLC-CAD -- HPLC-FID -- HPLC-MS -- HPLC-NMR -- LC-Hyphenation for Online Structural Identification -- HPLC-DAD (Diode-Array Detector) -- HPLC-MS, MS-MS, and MSn -- HPLC-NMR (Nuclear Magnetic Resonance) -- HPLC Biochemical Detection -- HPTLC-HPLC for Quality Assurance -- Case Study -- Different Chemical Classes from Natural Products and LC Fingerprints -- Fingerprints for Flavonoids -- Fingerprints for Terpenoids -- Fingerprints for Alkaloids -- Fingerprints for Coumarins -- Fingerprints for Alkamides -- References -- Bibliography -- 5. GC: Herbal Drugs and Fingerprints -- Instrumentation -- GLC Columns -- Detectors in GLC -- Development of GC Fingerprints and Data Interpretation -- Sample Preparation -- Separation and Detection -- Analytical Results -- Utility of GC Fingerprints in Herbal Drugs -- Contamination/Adulteration -- Traceability -- Qualification and Quantification of Therapeutics -- Nutraceutical Discovery -- New Cosmeceuticals -- In Aromatherapy -- To Decipher Traditional Formulations -- References -- Bibliography -- Pt. III. Herbal Drugs and Spectral Fingerprints -- 6. UV-Vis. Spectroscopy: Herbal Drugs and Fingerprints -- Instrumentation -- UV-Vis. Spectrometry and Herbal Drugs -- To Study the Phenolics and Derivatives -- UV Spectrometry for Different Derivatives -- UV-Vis. Coupled Methods for Analysis -- Preparation of Sunscreens -- Evaluation of Vitamin C Content -- Preparation of Stock Solutions -- Green Synthesis of Nanoparticles -- SNPs from C. tamala Twigs -- Purification of Geometrical Isomers -- Analysis of Ultra-Diluted Drugs -- Identification of Powdered Medicinal Plants -- Biological Assay Using Hyphenated Techniques -- To Differentiate Various Species of a Genus -- References -- Bibliography -- 7. FTIR Spectroscopy: Herbal Drugs and Fingerprints -- Interpretation of IR Spectra -- Authentication of Herbal and Herbal Drugs -- Interpretation of Data -- Identification and Comparison of Biomolecules -- Authenticity of Herbal and Herbal Drugs -- To Distinguish Herb from Its Morphological Fakes -- Standardization of Metal-Based Herbal Drugs -- References -- Bibliography -- 8. Mass Spectroscopy: Herbal Drugs and Fingerprints -- Interpretation of Mass Spectra -- Techniques for Analysis of Ions in MS -- Detection and Recording of Fingerprints -- Electrospray MS for Herbal Fingerprints -- Matrix-Assisted Laser Desorption Ionization -- Hyphenated Techniques -- References -- Bibliography -- 9. NMR Spectroscopy: Herbal Drugs and Fingerprints -- Metabolic Fingerprints -- Case Study 1 -- 1H-NMR Detection -- 1H-NMR Spectra to Recognize Patterns and Find Discriminating Signals -- 2D-NMR Spectroscopy to Compare Metabolites -- Evaluation of Quality of High Therapeutic-Value Herbals -- Case Study 2 -- Materials and Chemicals -- Molecular Modeling -- Case Study 3 -- To Decipher the Herbal Constituents -- Case Study 4 -- Metabolic Fingerprints to Distinguish Plant Species -- Case Study 5 -- Quality Assurance of Traditional Medicines -- Case Study 6 -- Detection of Contaminations -- References -- Bibliography -- Pt. IV. Pollutants in Herbal Drugs and Fingerprints -- 10. Metals in Herbal Drugs and Fingerprints -- Atomic Absorption Spectroscopy -- Instrumentation in AAS -- Case Study 1 -- Case Study 2 -- Graphite Furnace Atomizer -- Inductively Coupled Plasma -- WDXRF Spectroscopy -- Heavy Metals -- Removal of Heavy Metals from Herbal Drugs -- Case Study 3 -- Bhasmas as Nanoherbal Drugs -- References -- Bibliography -- 11. Pesticide Residues in Herbals and Detection -- Regulatory Norms -- Analysis of Pesticide Residues -- Isolation and Purification Methods -- Hyphenated Techniques for Isolation and Purification -- Contemporary Trends in Pesticide Residue Analysis -- Degree of Uncertainty of Analysis -- Pesticides Residues in Natural Products -- Current Scenario of Pesticides Residues in Herbals -- Pesticide Residues in Dry Fruits -- TLC Fingerprints -- GC Fingerprints -- References -- Bibliography -- 12. Radiation Detection in Herbals -- Microorganisms in Herbals -- Safety and Effectiveness of Irradiation -- Irradiation of Spices and Dried Vegetable Seasonings -- Irradiation Dose for Essential Oils and Organoleptic Characters -- Radiation Quantity and Antioxidant Activity -- Detection of Irradiated Foods and Food Supplements -- Thermoluminescence -- Pulse Photo-Stimulated Luminescence -- Electron Paramagnetic Spin Resonance Spectroscopy -- References -- Bibliography -- Pt. V. DNA Techniques for Evidence-Based Herbals -- 13. Herbal Drugs and DNA Fingerprints -- Authentication of Traditional Formulations -- Experimental Details -- RAPD Reaction -- Identification of Chemotypes, Ecotypes, and Substitutes -- Case Study -- Identification of Adulterants -- DNA Fingerprint Techniques for Identification of Ingredients -- Polymerase Chain Reaction -- Simple Sequence Repeats -- Restriction Fragment Length Polymorphisms -- Amplified Fragment Length Polymorphism -- Random Amplified Polymorphism -- Single-Nucleotide Polymorphism -- Short Tandem Repeat -- DNA Barcode -- Genetic Markers -- Trouble Shooting in DNA Fingerprinting -- Commercial Utility of Genetic Markers in Herbal Technology -- Comparative Genetic Analysis -- Future Scope of Genetic Markers in Herbal Drug Research -- References -- Bibliography.
- Format
- e-Book
- Location
- Online
Healthcare Overview : New Perspectives
https://libcat.nshealth.ca/en/permalink/provcat31283
Vincenzo Costigliola, editor.
--Dordrecht:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Just a few years ago, dire predictions of escalating technology costs and adverse demographics informed a downbeat view of the future of medicine in which struggling governments would fall behind in their public commitments to healthcare. This volume is part of today's more optimistic assessment in which huge efficiencies can be wrought through 'personalized' medicine: patients, for example, have no need to visit clinics when biochemical monitoring can be achieved in the comfort of their own ho…
- Available Online
- View e-Book
- Other Authors
- Costigliola, Vincenzo
- Responsibility
- Vincenzo Costigliola, editor
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xviii, 521 p. : 86 ill., 73 ill. in color)
- Series Vol.
- v. 1
- ISBN
- 9789400746022
- Subjects (MeSH)
- Individualized Medicine - trends
- Global Health - trends
- Subjects (LCSH)
- Public health
- Abstract
- Just a few years ago, dire predictions of escalating technology costs and adverse demographics informed a downbeat view of the future of medicine in which struggling governments would fall behind in their public commitments to healthcare. This volume is part of today's more optimistic assessment in which huge efficiencies can be wrought through 'personalized' medicine: patients, for example, have no need to visit clinics when biochemical monitoring can be achieved in the comfort of their own homes, the results sent wirelessly, in real time, to the specialist's database. With contributions spanning the experiences of 15 nations from the USA to Turkey, Taiwan and the UK, the contents of this book show what is possible in implementing personalized medicine in a heterogeneous set of contexts. Today's burgeoning use of advanced early and predictive diagnostics, targeted prevention and personalized medical approaches will accelerate as advances in patient profiling and innovative bio/medical technologies come on stream. They could enable many of tomorrow's elderly to reach 100 years of age in good physical and mental health, as actively contributing members of society. The scope of coverage in this volume provides a comprehensive and unrivaled review of historical, cultural, demographic, ethnic, socio-economic, political, and other aspects of personalized medicine. It shows that reaping the benefits of this kind of medical care requires careful regulations in healthcare and skilful political planning.
- Contents
- [Machine generated contents note] Global Process of Personalisation in Medicine: New Perspectives in Healthcare / Vincenzo Costigliola -- Pt. I. Healthcare Systems Around the Globe -- Italian Healthcare System in the Global Context: The Cultural Challenge of Predictive, Preventive and Personalized Medicine / Francesco Basile -- Healthcare in the UK - Predictive, Preventive and Personalised Medicine Perspective at the Beginning of the Twenty-First Century / Jane Burbidge -- German Healthcare System / Friedemann Paul -- Healthcare Overview in the Slovak Republic and Implementation of Predictive, Preventive and Personalized Medicine / Ladislav Turecky -- Overview of the Healthcare System in the Czech Republic with Respect to Predictive, Preventive and Personalized Medicine / Ondrej Topolcan -- Perpetual Transitions in Romanian Healthcare / Mircea Marzan -- Overview of the Healthcare System in Georgia / Tamari Rukhadze -- Genera] Overview of the Healthcare System in the Republic of Macedonia: Health Indicators, Organization of Healthcare System and Its Challenges / Kneginja Richter -- Overview of the Healthcare System in Turkey / Sevda Yesim Ozdemir -- Taiwan’s Healthcare Report / Willie Sai Ho Chan -- Mobility of Medical Doctors as an Attribute of the Cross-Border Healthcare: Challenges, Opportunities and Perspectives / Vincenzo Costigliola -- Where Is the European Pharma Industry Going? / Michele Antonelli -- Pt. II. Female Health/Care -- Changing Long-Held Beliefs Is Never Easy: A Proposal for Multimodal Approaches in Female Healthcare - An Integrative View / Olga Golubnitschaja -- Gender-Specific Nutritional Approach to Women’s Healthcare / Niva Shapira -- Implications of Gender Based Biology in Oral Health Issues - Are Women More Susceptible? / Connie Drisko -- Simultaneous Systematic Approach to Enable Predictive, Preventive and Personalized Medicine - Women Healthcare as a Case Study / Hamutal Meiri -- Pt. III. Traditional and Non-Conventional Medicine -- Widening the Paradigm in Medicine and Health: Person-Centred Medicine as the Common Ground of Traditional, Complementary, Alternative and Non-Conventional Medicine / Paola Guadagni -- Music Therapy, a Personalised Bridge Towards Healing Beyond Surgery and Medication: European Paediatrics Overview / Reiner Haus -- Pt. IV. Role of Laboratory Medicine in Healthcare -- Characterization and Validation of Biomarkers by Immunoassays: Quality Requirements, Physical Standards and Data Management in Predictive Medicine / Kurt Krapfenbauer -- Pt. V. Economy of PPPM -- Effectiveness, Cost Effectiveness, and Financial Viability of Personalized Medicine: A Role for Comparative Effectiveness Research? / Paul M. Brown -- Economic Challenge of Predictive, Preventive and Personalized Medicine: The Case Study of Lung, Head and Neck Cancer / Kurt Krapfenbauer -- Health Promotion and Prevention in Companies - Economic Aspects and Prevention Strategies for Shift Work Sleep Disorders / Guenter Niklewski -- Pt. VI. Ethics of PPPM -- New Ethical Paradigm in Preventive, Predictive and Personalised Medicine / Dainius Characiejus.
- Format
- e-Book
- Location
- Online
Pediatric bone : biology & diseases
https://libcat.nshealth.ca/en/permalink/provcat31882
edited by Francis H. Glorieux, John M. Pettifor, Harald Jüppner.
(2nd ed.)
--Waltham, MA:
Elsevier
, c2012.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Glorieux, Francis H
- Pettifor, John M
- Jüppner, Harald
- Responsibility
- edited by Francis H. Glorieux, John M. Pettifor, Harald Jüppner
- Edition
- 2nd ed.
- Place of Publication
- Waltham, MA
- Publisher
- Elsevier
- Date of Publication
- c2012
- Physical Description
- 1 online resource (853 p)
- ISBN
- 9780123820402
- Subjects (LCSH)
- Bones
- Bone diseases in children
- Bone Development
- Bone Diseases
- Bone and Bones - abnormalities
- Bone and Bones - physiology
- Child
- Contents
- 1. Bone cell biology: osteoclasts, osteoblasts, osteocytes / Katharine Jähn and Lynda F. Bonewald -- 2. Bone matrix and mineralization / Marc D. McKee and William G. Cole -- 3. Prenatal bone development / Fanxin Long -- 4. Postnatal bone growth: growth plate biology, bone formation, and remodeling / Christa Maes and Henry M. Kronenberg -- 5. Dental development and maturation, from the dental crypt to the final occlusion / Jean-Marc Retrouvey, Michel Goldberg and Stéphane Schwartz -- 6. Parathyroid hormone and calcium homeostasis / John T. Potts and Thomas J. gardella -- 7. Phosphate homeostasis regulatory mechanisms / Clemens Bergwitz and Harald Jüppner -- 8. Vitamin D biology / René St-Arnaud and Marie B. Demay -- 9. Peak bone mass and its regulation / Jean-Philippe Bonjour ... [et al.] -- 10. Pregnancy and lactation / Ann Prentice -- 11. Fetal mineral homeostasis / Christopher S. Kovacs -- 12. Radiology / Judith E. Adams ... [et al.] -- 13. Non-invasive techniques for bone mass measurement / Mary B. Leonard and Laura K. Bachrach -- 14. Assessment of maturation: bone age and pubertal assessment / Noël Cameron and David D. Martin -- 15. Biochemical markers of bone metabolism / Nick Shaw and Wolfgang Högler -- 16. Pediatric bone histomorphometry / frank Rauch -- 17. A diagnostic approach to skeletal dysplasias / Sheila Unger, Andrea Superti-Furga and David L. Rimoin -- 18. The spectrum of pediatric osteoporosis / Maria Luisa Bianchi and Francis H. Glorieux -- 19. Osteogenesis imperfecta / Francis H. Glorieux and David Rowe -- 20. Sclerosing bone dysplasias / Bram Perdu ... [et al.] -- 21. Parathyroid disorders / Murat Bastepe, Harald Jüppner and Rajesh V. Thakker -- 22. Fibrous dysplasia / Paolo Bianco and Shlomo Wientroub -- 23. Nutritional rickets / John M. Pettifor -- 24. Metabolic bone disease in the neonatal period and its later sequelae / Nick Bishop, Mary Pewtrell and Nick Harvey -- 25. Rickets due to hereditary abnormalities of vitamin D synthesis or action / Anthony A. Portale, Farzana Perwad and Walter L. Miller -- 26. Familial hypophosphatemia and related disorders / Ingrid A. Holm, Michael J. Econs and Thomas O. Carpenter -- 27. Hereditary tubular disorders of mineral handling / Daniella Magen and Israel Zelikovic -- 28. Hypophosphatasia / michael P. Whyte -- 29. Chronic kidney disease mineral and bone disorder / Katherine Wesseling Perry and Isidro B. Salusky -- 30. Extraskeletal bone formation / Eileen M. Shore and Frederick S. Kaplan.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Medical biochemistry : an illustrated review
https://libcat.nshealth.ca/en/permalink/provcat42068
Sankhavaram R. Panini.
--New York, NY:
Thieme
, c2013.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Panini, Sankhavaram R.
- Responsibility
- Sankhavaram R. Panini
- Place of Publication
- New York, NY
- Publisher
- Thieme
- Date of Publication
- c2013
- Physical Description
- 1 online resource (ix, 453 p.) : ill.
- Series
- Illustrated review series
- Series Title
- Thieme's illustrated review series
- ISBN
- 9781604063165
- 9781604063172 (eISBN)
- Subjects (MeSH)
- Biochemical Phenomena
- Specialty
- Biochemistry
- Contents
- Nutrition & digestion -- Carbohydrates -- Lipids -- Amino acids & proteins -- Biochemical reactions & enzymes -- Membranes and transport -- Cell signaling -- Principles of cellular respiration -- Glycolysis and the metabolism of pyruvate and acetyl CoA -- Tricarboxylic acid cycle -- Oxidative phosphorylation and the mitochondria -- Carbohydrate metabolism -- Fatty acid metabolism -- Cholesterol and steroid metabolism -- Protein and amino acid metabolism -- Nucleotide and heme metabolism -- Replication -- Transcription -- Translation -- Cell cycle and cancer -- Biotechniques.
- Format
- e-Book
- Publication Type
- Outline
- Location
- Online
JIMD Reports. Volume 9 : Case and Research Reports, 2012/6
https://libcat.nshealth.ca/en/permalink/provcat42151
Johannes Zschocke, K. Michael Gibson, Garry Brown, Eva Morava, Verena Peters, editors.
--Berlin, Heidelberg:
Springer ; SSIEM
, c2013.
- Available Online
- View e-Book
- Location
- Online
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Available Online
- View e-Book
- Other Authors
- Society for the Study of Inborn Errors of Metabolism
- Responsibility
- Johannes Zschocke, K. Michael Gibson, Garry Brown, Eva Morava, Verena Peters, editors
- Alternate Title
- Journal of inherited metabolic disorders reports
- JIMD case and research reports
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer ; SSIEM
- Date of Publication
- c2013
- Physical Description
- 1 online resource (vii, 142 p.) : 46 illus
- Series Vol.
- v. 9
- Series Title
- JIMD reports
- ISBN
- 9783642355189
- 9783642355172 (print ed.)
- ISSN
- 2192-8304
- 2192-8312 (e)
- Subjects (MeSH)
- Metabolism, Inborn Errors
- Abstract
- JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
- Format
- e-Book
- Publication Type
- Case Reports
- Location
- Online
Ankylosing spondylitis and Klebsiella
https://libcat.nshealth.ca/en/permalink/provcat32337
Alan Ebringer, author.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Ankylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria. When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissu…
- Available Online
- View e-Book
- Author
- Ebringer, Alan
- Responsibility
- Alan Ebringer, author
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xx, 256 p. : 89 ill., 86 ill. in color)
- ISBN
- 9781447143000
- Subjects (MeSH)
- HLA-B27 antigen
- Klebsiella
- Spondylitis, Ankylosing - etiology
- Subjects (LCSH)
- Rheumatology
- Abstract
- Ankylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria. When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will attack not only the bacteria but also the self tissues such as the joints and the cells having the same HLA molecules, which is how the disease AS starts. This is the concept of molecular similarity or "molecular mimicry" which previously has been found to work in two other autoimmune diseases; rheumatic fever and rheumatoid arthritis. The first paper on this subject was published in 1976 and since then over 100 papers on rheumatological topics have been published, from Prof Ebringer's group, at the Division of Life Sciences, King's College in London, UK. The relevant information from these papers is extracted and presented in this book format making it accessible to health professionals, research institutions, pharmaceutical companies and universities and the general public.
- Contents
- Ankylosing spondylitis as a scientific problem -- History of the origin of ankylosing spondylitis -- The discovery of HLA-B27 in ankylosing spondylitis and related disorders -- Molecular mimicry between HLA-B27 and Klebsiella bacteria investigated by using rabbit antisera -- Molecular mimicry between HLA-B27 and Klebsiella bacteria investigated by using human tissue typing sera -- Muscle changes in ankylosing spondylitis -- Raised serum IgA is present in ankylosing spondylitis patients -- Faecal cultures in ankylosing spondylitis and uveitis -- Biochemical parameters and Klebsiella in ankylosing spondylitis -- Binding of Klebsiella antisera to HLA-B27 cells -- IgA antibodies to Klebsiella and other Gram-negative bacteria in ankylosing spondylitis -- IgA antibodies to Klebsiella measured by immunoblotting -- Antibodies to Klebsiella in ankylosing spondylitis measured by bacterial agglutination and ELISA against lipopolysaccharides -- Dutch and German patients with ankylosing spondylitis have antibodies to Klebsiella -- Spanish, Finnish and Swedish patients with ankylosing spondylitis have antibodies to Klebsiella -- Molecular mimicry between Klebsiella pullulanase enzyme, HLA-B27 and collagens I and IV -- Antibodies to Klebsiella and HLA-B27 peptides in ankylosing spondylitis patients from southern Japan -- Ankylosing spondylitis sera are cytotoxic to cells bearing HLA-B27 sequences -- Pathogenesis of ankylosing spondylitis and Klebsiella substrates -- Ankylosing spondylitis and the "low starch diet" -- The problem of Crohn's disease and Klebsiella -- Ankylosing spondylitis and "Popper sequences" -- Index.
- Format
- e-Book
- Location
- Online
