Abeta Peptide and Alzheimer's Disease : Celebrating a Century of Research
https://libcat.nshealth.ca/en/permalink/provcat40582
Colin J. Barrow and David H. Small (eds.).
--London:
Springer
, c2007.
- Available Online
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- Location
- Online
Abeta Peptide and Alzheimer's Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer's Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although…
- Available Online
- View e-Book
- Other Authors
- Barrow, Colin J
- Small, David H
- Responsibility
- Colin J. Barrow and David H. Small (eds.)
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2007
- Physical Description
- 1 online resource (xi, 298 p.)
- ISBN
- 9781846284403
- 9781852339616 (print ed.)
- Subjects (MeSH)
- Alzheimer Disease - etiology
- Alzheimer Disease - metabolism
- Amyloid beta-Peptides - metabolism
- Abstract
- Abeta Peptide and Alzheimer's Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer's Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rapidly moving area, the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases, such as prion disease, Parkinson's and Huntington's. This book will primarily be of interest to AD researchers and clinicians but also to researchers of other amyloid diseases.
- Contents
- A Brief Introduction to the History of the ß-Amyloid Protein (Aß) of Alzheimer’s Disease -- The Aßcentric Pathway of Alzheimer's Disease -- The Function of the Amyloid Precursor Protein Family -- The Involvement of Aß in the Neuroinflammatory Response -- Amyloid ß-Peptide(1-42), Oxidative Stress, and Alzheimer's Disease -- Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease -- Aß Variants and Their Impact on Amyloid Formation and Alzheimer's Disease Progression -- Copper Coordination by ß-Amyloid and the Neuropathology of Alzheimer's Disease -- Cholesterol and Alzheimer's Disease -- Amyloid ß-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer's Disease Pathology -- Physiologic and Neurotoxic Properties of Aß Peptides -- Impact of ß-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models -- Glial Cells and Aß Peptides in Alzheimer's Disease Pathogenesis -- The Role of Presenilins in Aß-Induced Cell Death in Alzheimer's Disease -- Immunotherapeutic Approaches to Alzheimer's Disease -- Mouse Models of Alzheimer's Disease.
- Format
- e-Book
- Location
- Online
Acute Nephrology for the Critical Care Physician
https://libcat.nshealth.ca/en/permalink/provcat39281
Heleen M. Oudemans-van Straaten, Lui G. Forni, A.B. Johan Groeneveld, Sean M. Bagshaw, Michael Joannidis, editors.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This practical guide provides the reader with answers to important clinically relevant questions regarding the evaluation and management of acute kidney injury (AKI). All aspects of critical care nephrology are covered, from pathophysiology and diagnosis to prevention and treatment. The questions considered relate to a wide range of issues, such as: How do I diagnose AKI? How can I protect the kidney in clinical practice? How do I manage patients with AKI? When should I initiate and how do I pe…
- Available Online
- View e-Book
- Other Authors
- Oudemans-van Straaten, Heleen M
- Forni, Lui G
- Groeneveld, A.B. Johan
- Bagshaw, Sean M
- Joannidis, Michael
- Responsibility
- Heleen M. Oudemans-van Straaten, Lui G. Forni, A.B. Johan Groeneveld, Sean M. Bagshaw, Michael Joannidis, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (viii, 286 p. : 22 illus., 19 illus. in color)
- ISBN
- 9783319173894
- 9783319173887 (print ed.)
- Abstract
- This practical guide provides the reader with answers to important clinically relevant questions regarding the evaluation and management of acute kidney injury (AKI). All aspects of critical care nephrology are covered, from pathophysiology and diagnosis to prevention and treatment. The questions considered relate to a wide range of issues, such as: How do I diagnose AKI? How can I protect the kidney in clinical practice? How do I manage patients with AKI? When should I initiate and how do I perform renal replacement therapy (RTT)? Which type of RTT is most appropriate for my patient? Should I give specific nutrients? In addition to providing practical guidelines and treatment algorithms, the book includes calculators for continuous RRT and anticoagulant dosing. The authors are internationally renowned experts in the fields of Intensive Care Medicine and Nephrology, and all contributions are written in a clear and concise style and have been peer reviewed. Acute Nephrology for the Critical Care Physician will serve as a very useful source for intensivists, internists, anesthesiologists, and nephrologists involved in the management and treatment of critically ill patients at risk of or affected by AKI.
- Contents
- Part I. Acute Kidney Injury -- 1 AKI: Defi nitions and Clinical Context -- 2 Epidemiology of AKI -- 3 Renal Outcomes After Acute Kidney Injury -- 4 Etiology and Pathophysiology of Acute Kidney Injury -- 5 Acid–Base -- 6 Kidney-Organ Interaction -- 7 Acute Kidney Injury in Pregnancy -- Part II. Diagnosis of AKI -- 8 Classical Biochemical Work Up of the Patient with Suspected AKI -- 9 Acute Kidney Injury Biomarkers -- 10 Renal Imaging in Acute Kidney Injury -- Part III. Prevention and Protection -- 11 Prevention of AKI and Protection of the Kidney -- Part IV. Renal Replacement Therapy -- 12 Timing of Renal Replacement Therapy -- 13 Dose of Renal Replacement Therapy in AKI -- 14 Type of Renal Replacement Therapy -- 15 Anticoagulation for Continuous Renal Replacement Therapy -- 16 Metabolic Aspects of CRRT -- 17 Continuous Renal Replacement Therapy in Sepsis: Should We Use High Volume or Specific Membranes? -- 18 Drug Removal by CRRT and Drug Dosing in Patients on CRRT -- 19 Renal Replacement Therapy for Intoxications -- 20 Pediatric CRRT -- 21 Operational and Nursing Aspects.
- Format
- e-Book
- Location
- Online
Adler's physiology of the eye
https://libcat.nshealth.ca/en/permalink/provcat31646
Leonard A. Levin, Siv F.E. Nilsson, James Ver Hoeve ... [et al.].
(11th ed.)
--Edingburg:
Saunders Elsevier
, c2011.
- Available Online
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- Registration required for PDF access.
- Location
- Online
Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F.E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, help…
- Available Online
- View e-Book
- Other Authors
- Levin, Leonard A
- Responsibility
- Leonard A. Levin, Siv F.E. Nilsson, James Ver Hoeve ... [et al.]
- Edition
- 11th ed.
- Alternate Title
- Physiology of the eye
- Place of Publication
- Edingburg
- Publisher
- Saunders Elsevier
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xii, 795 p.)
- ISBN
- 9780323081160
- Subjects (MeSH)
- Ocular Physiological Phenomena
- Subjects (LCSH)
- Eye--Physiology
- Abstract
- Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv F.E. Nilsson, James Ver Hoeve, and Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye, updated to enhance your understanding of ocular function. This full-color, user-friendly edition captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. A new organization by function, rather than anatomy, helps you make a stronger connection between physiological principles and clinical practice; and more than 1,000 great new full-color illustrations help clarify complex concepts.
- Contents
- Focusing of an image on the retina -- Physiology of optical media -- Direction of gaze -- Nutrition of the eye -- Protection of the eye -- Photoreception -- Visual processing in the retina -- Non-perceptive vision -- Visual processing in the brain -- Visual perception -- Development and deprivation of vision.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Adolescent Health and Wellbeing : Current Strategies and Future Trends
https://libcat.nshealth.ca/en/permalink/provcat44756
Alessandro Pingitore, Francesca Mastorci, Cristina Vassalle, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and t…
- Available Online
- View e-Book
- Other Authors
- Pingitore, Alessandro
- Mastorci, Francesca
- Vassalle, Cristina
- Responsibility
- Alessandro Pingitore, Francesca Mastorci, Cristina Vassalle, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xii, 352 p.) : 45 illus., 37 illus. in color
- ISBN
- 9783030258160
- 9783030258153 (Print ed.)
- 9783030258177 (Print ed.)
- 9783030258184 (Print ed.)
- Subjects (MeSH)
- Adolescent
- Health Promotion
- Preventive Medicine
- Social Determinants of Health
- Subjects (LCSH)
- Pediatrics
- Health promotion
- Primary care (Medicine)
- Medical policy
- Child psychiatry
- Specialty
- Adolescent Health
- Abstract
- This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and the clinical and prognostic implications of primordial prevention in healthy adolescents. All of these elements are subsequently reviewed using a multidimensional approach, in order to offer extensive information on the complex changes that characterize adolescents’ physiological, psychological, and neurobiological development. In addition, the book depicts the preventive strategies currently used in various social settings (school, family, sport club, health policies) aimed not only at reducing lifestyle risk behaviors, but also at improving resilience, happiness, social involvement, self-esteem, and sociability. This update is essential in the light of the fact that, to date, prevention has mainly been directed towards adolescents with physical or mental disorders rather than their healthy peers. As such, the book offers a valuable tool for pediatricians, child and adolescents psychiatrists, and for all professionals involved in Health Promotion and Disease Prevention.
- Contents
- Part I. Primordial Prevention: General Aspects - 1. Preventive Primordial Strategies: Times Are Changing -- 2. Fetal Programming of Adult Disease in a Translational Point of View -- 3. Physical Activity, Sedentary Behaviour and Mental Health in Young People: A Review of Reviews -- 4. Habits and Quality of Diet -- 5. Biochemical Markers in Primordial Prevention: Premises and Promises -- Part II. Adolescents’ Mental Health and Well-Being -- 6. Prenatal and Early Postnatal Influences on Neurodevelopment: The Role of Epigenetics -- 7. The Role of Environmental Enrichment on Neurodevelopment: Emotion Regulation in Adolescence as a Model Paradigm -- 8. Relationship Between Emotions, Sleep and Well-Being -- 9. Adolescents in the 21st Century: Back to Dialogue from Marked Lives vs Dreamed Lives -- Part III. Adolescence and the Social Determinants of Health -- 10. Adolescence and Social Determinants of Health: Family and Community -- 11. The Role of Well-Being in the School of Inclusion -- 12. Two-Faced Janus: The Role of Peers in Adolescence -- Part IV. The Digital Era in Adolescent’s Health and Well-Being -- 13. Adolescence Between Past and Future -- 14. e-Health Strategies -- 15. Images and Perspectives of Play for Children’s and Adolescents’ Well-being -- 16. New Perspectives for Multidisciplinary and Integrated Strategies of Adolescent Health and Well-being.
- Format
- e-Book
- Location
- Online
Aging and heart failure : mechanisms and management
https://libcat.nshealth.ca/en/permalink/provcat33590
Bodh I. Jugdutt, editor.
--New York:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactio…
- Available Online
- View e-Book
- Other Authors
- Jugdutt, Bodh I
- Responsibility
- Bodh I. Jugdutt, editor
- Place of Publication
- New York
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource
- ISBN
- 9781493902682 (electronic bk.)
- 9781493902675
- Subjects (MeSH)
- Aging - physiology
- Heart Failure
- Subjects (LCSH)
- Heart failure
- Older people - Medical care
- Abstract
- This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis; and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists, and internists.
- Contents
- Changing Demographics of the Aging Population with Heart Failure and Implications for Therapy -- Biology of Aging and Implications for Heart Failure Therapy and Prevention -- Hypertension and Prevention of Diastolic Heart Failure in the Aging Population -- Aging and Optimal Therapy of Systolic Heart Failure in the Elderly -- Atrial Fibrillation and Heart Failure in the Aging Population -- Optimizing Therapy of Heart Failure in the Aging Population with Monitoring in Clinics -- Cardiac Alterations in Aging, Hypertension, and Diastolic Heart Failure -- Polypharmacy and Adverse Drug Reactions in the Aging Population with Heart Failure -- Age-Related Changes in Vascular Biology and Implications for Heart Failure Therapy in the Aging Population -- Biomarkers and Optimal Management of Heart Failure in the Aging Population -- Benefits of Exercise in the Elderly -- The RAAS in Heart Failure: An Update on Clinical Trials and Opportunities for Therapy -- Aging and Diastolic Dysfunction: The Interplay of Inflammation and Extracellular Matrix Regulation -- Reperfusion and Vasodilator Therapy in Elderly Patients with STEMI and Heart Failure: Improving Outcomes -- Erythropoietin Therapy for Heart Failure -- Role of Resistin in Heart Failure in the Elderly -- Role of Coronary Artery Calcium in Cardiovascular Risk Stratification and Management in the Aging Population -- Aging and Remodeling of the RAS and RAAS and Related Pathways: Implications for Heart Failure Therapy -- Aging and Right Ventricular Failure from Pulmonary Hypertension: Effect of Right Ventricular and Pulmonary Artery Remodeling -- Aging and Right Ventricular Failure from Pulmonary Hypertension: Effect of Right Ventricular and Pulmonary Artery Remodeling -- Biomarkers of Cardiovascular Aging -- Changes in the Heart That Accompany Advancing Age: Humans to Molecules -- Aging-Related Changes in Cell Death and Cell Survival Pathways and Implications for Heart Failure Therapy -- Aging-Related Changes in Telomeres and Telomerases and Implications for Heart Failure Therapy -- Aging-Associated Alterations in Myocardial Inflammation and Fibrosis: Pathophysiological Perspectives and Clinical Implications -- Aging-Related Changes in Extracellular Matrix: Implications for Ventricular Remodeling Following Myocardial Infarction -- Calcium-Handling Defects and Changes in Cardiac Function in the Aging Heart -- Integrins: Implications for Aging in Heart Failure Therapy -- Adipokines as Novel Biomarkers in Aging and Heart Failure -- Aging-Related Changes in Cellular and Molecular Mechanisms of Postinfarction Remodeling: Implications for Heart Failure Therapy -- Aging-Related Changes in Mitochondrial Function and Implication for Heart Failure Therapy -- Regulation of SERCA Via Oxidative Modifications: Implications for the Pathophysiology of Diastolic Dysfunction in the Aging Heart -- SMP30 and Aging-Related Cardiac Remodeling and Heart Failure.
- Format
- e-Book
- Location
- Online
Ankylosing spondylitis and Klebsiella
https://libcat.nshealth.ca/en/permalink/provcat32337
Alan Ebringer, author.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Ankylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria. When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissu…
- Available Online
- View e-Book
- Author
- Ebringer, Alan
- Responsibility
- Alan Ebringer, author
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xx, 256 p. : 89 ill., 86 ill. in color)
- ISBN
- 9781447143000
- Subjects (MeSH)
- HLA-B27 antigen
- Klebsiella
- Spondylitis, Ankylosing - etiology
- Subjects (LCSH)
- Rheumatology
- Abstract
- Ankylosing spondylitis and Klebsiella is a comprehensive and informative text on the cause of Ankylosing spondylitis. Ankylosing spondylitis (AS) is a condition which affects 20 million people worldwide and is likely caused or initiated by a bowel infection from Klebsiella bacteria. When a patient is infected by Klebsiella bacteria, his or her immune system will make antibodies against all the antigens or molecules found in the microbe. Because some of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will attack not only the bacteria but also the self tissues such as the joints and the cells having the same HLA molecules, which is how the disease AS starts. This is the concept of molecular similarity or "molecular mimicry" which previously has been found to work in two other autoimmune diseases; rheumatic fever and rheumatoid arthritis. The first paper on this subject was published in 1976 and since then over 100 papers on rheumatological topics have been published, from Prof Ebringer's group, at the Division of Life Sciences, King's College in London, UK. The relevant information from these papers is extracted and presented in this book format making it accessible to health professionals, research institutions, pharmaceutical companies and universities and the general public.
- Contents
- Ankylosing spondylitis as a scientific problem -- History of the origin of ankylosing spondylitis -- The discovery of HLA-B27 in ankylosing spondylitis and related disorders -- Molecular mimicry between HLA-B27 and Klebsiella bacteria investigated by using rabbit antisera -- Molecular mimicry between HLA-B27 and Klebsiella bacteria investigated by using human tissue typing sera -- Muscle changes in ankylosing spondylitis -- Raised serum IgA is present in ankylosing spondylitis patients -- Faecal cultures in ankylosing spondylitis and uveitis -- Biochemical parameters and Klebsiella in ankylosing spondylitis -- Binding of Klebsiella antisera to HLA-B27 cells -- IgA antibodies to Klebsiella and other Gram-negative bacteria in ankylosing spondylitis -- IgA antibodies to Klebsiella measured by immunoblotting -- Antibodies to Klebsiella in ankylosing spondylitis measured by bacterial agglutination and ELISA against lipopolysaccharides -- Dutch and German patients with ankylosing spondylitis have antibodies to Klebsiella -- Spanish, Finnish and Swedish patients with ankylosing spondylitis have antibodies to Klebsiella -- Molecular mimicry between Klebsiella pullulanase enzyme, HLA-B27 and collagens I and IV -- Antibodies to Klebsiella and HLA-B27 peptides in ankylosing spondylitis patients from southern Japan -- Ankylosing spondylitis sera are cytotoxic to cells bearing HLA-B27 sequences -- Pathogenesis of ankylosing spondylitis and Klebsiella substrates -- Ankylosing spondylitis and the "low starch diet" -- The problem of Crohn's disease and Klebsiella -- Ankylosing spondylitis and "Popper sequences" -- Index.
- Format
- e-Book
- Location
- Online
Articular Cartilage of the Knee : Health, Disease and Therapy
https://libcat.nshealth.ca/en/permalink/provcat45489
Harpal K. Gahunia, Allan E. Gross, Kenneth P.H. Pritzker, Paul S. Babyn, Lucas Murnaghan, editors.
--New York, NY:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
Covering both pediatric and adult populations, this comprehensive text covers the diverse topics related to the health, disease and therapy of articular cartilage of the knee, from basic principles to future directions for research. This vast array of information is arranged into eight sections, encompassing a number of relevant disciplines and covering, in turn, normal articular cartilage, aging and degeneration, evaluation and assessment, non-surgical approaches, surgical approaches, qualitat…
- Available Online
- View e-Book
- Other Authors
- Gahunia, Harpal K.
- Gross, Allan E.
- Pritzker, Kenneth P.H.
- Babyn, Paul S.
- Murnaghan, Lucas
- Responsibility
- Harpal K. Gahunia, Allan E. Gross, Kenneth P.H. Pritzker, Paul S. Babyn, Lucas Murnaghan, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xxxviii, 498 p.) : 145 illus., 85 illus. in color
- ISBN
- 9781493975877
- 9781493975853 (Print ed.)
- 9781493975860 (Print ed.)
- Specialty
- Orthopedics
- Abstract
- Covering both pediatric and adult populations, this comprehensive text covers the diverse topics related to the health, disease and therapy of articular cartilage of the knee, from basic principles to future directions for research. This vast array of information is arranged into eight sections, encompassing a number of relevant disciplines and covering, in turn, normal articular cartilage, aging and degeneration, evaluation and assessment, non-surgical approaches, surgical approaches, qualitative and quantitative assessment of repair, research into cartilage repair and engineering, and future prospects for therapy. Each chapter is amply referenced and self-contained for independent study and reference. Scoring systems for knee cartilage assessment are included in four appendices as well, rounding out the presentation. A multidisciplinary collection of basic, translational and clinical material, Articular Cartilage of the Knee is a singular resource for orthopedic surgeons, rheumatologists, pathologists, scientists, tissue engineers and the broad spectrum of clinical professionals working with articular cartilage and its disorders.
- Contents
- Part I. Normal Articular Cartilage -- Structure and Function of Articular Cartilage -- Growth and Development of Articular Cartilage -- Part II. Aging, Degeneration and Physiologic Articular Cartilage Healing -- Articular Cartilage: Homeostasis, Aging and Degeneration -- Articular Cartilage Degradation: Biochemical Markers and Dynamic Loading -- Part III. Knee Articular Cartilage Injury: Evaluation and Assessment -- Acute and Chronic Traumatic Cartilage Injuries of the Knee -- Diagnostic Imaging of Knee Cartilage Injury: Evaluation and Assessment -- Assessment of Knee Cartilage Injury: Arthroscopic Evaluation and Classification -- Part IV. Repair of Knee Articular Cartilage Injury: Non-Operative Approach -- Physical and Rehabilitative Therapy for Knee Cartilage Injury and Disease -- Pharmacologic Agents for Knee Articular Cartilage Injury and Disease -- Part V. Repair of Knee Articular Cartilage: Surgical Approach -- Osteochondritis Dissecans of the Knee: Pathophysiology and Treatment -- Surgical Approach to Articular Cartilage Repair -- Clinical Outcome Assessment of Repaired Articular Cartilage -- Part VI. Qualitative and Quantitative Assessment of Articular Cartilage Repair -- Pre- and Post-Operative Imaging of Knee Articular Cartilage -- MRI of the Ultrastructural Composition of Articular Cartilage in Disease and Repair -- Histopathological Evaluation of Articular Cartilage Disease and Repair -- Part VII. Research in Cartilage Repair and Cartilage Engineering Strategies -- Human Derived Cells in Chondral or Osteochondral Repair -- Relevance of Engineered Scaffolds for Cartilage Repair -- Commercially Available Bio-Engineered Cartilage Grafts -- Part VIII. Future Prospects for Knee Articular Cartilage Therapy -- Knee Articular Cartilage: Future Directions for Research and Practice.
- Format
- e-Book
- Location
- Online
Atlas of Genetic Diagnosis and Counseling
https://libcat.nshealth.ca/en/permalink/provcat41222
Harold Chen.
(Third edition)
--New York, NY:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
Dr. Harold Chen shares his almost 50 years of clinical genetics practice in this new edition of a comprehensive pictorial atlas, featuring almost 290 genetic disorders, malformations, and malformation syndromes. The author provides a detailed outline for each disorder, describing its genetics, basic defects, clinical features, diagnostic tests, and counseling issues, including recurrence risk, prenatal diagnosis, and management. Numerous color photographs of prenatal ultrasounds, imagings, cyto…
- Available Online
- View e-Book
- Author
- Chen, Harold
- Responsibility
- Harold Chen
- Edition
- Third edition
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xxiii, 3080 pages) : 1242 illus., 1050 illus. in color
- Series Title
- Springer reference
- ISBN
- 9781493924011
- 9781493924004 (print ed.)
- Subjects (MeSH)
- Genetic Counseling
- Genetic Diseases, Inborn
- Prenatal Diagnosis
- Abstract
- Dr. Harold Chen shares his almost 50 years of clinical genetics practice in this new edition of a comprehensive pictorial atlas, featuring almost 290 genetic disorders, malformations, and malformation syndromes. The author provides a detailed outline for each disorder, describing its genetics, basic defects, clinical features, diagnostic tests, and counseling issues, including recurrence risk, prenatal diagnosis, and management. Numerous color photographs of prenatal ultrasounds, imagings, cytogenetics, and postmortem findings illustrate the clinical features of patients at different ages, patients with varying degrees of severity, and the optimal diagnostic strategies. The disorders cited are supplemented by case histories and diagnostic confirmation by cytogenetics, biochemical, and molecular techniques, when available. Since the publication of the previous edition in 2012, the atlas has been widely accepted and used in light of rapid progress in genetic and gnomic information. In this new edition, additional genetic disorders are added, as well as extensive updates to the previous disorders with new illustrations, supplemented by case and family history, clinical features, and laboratory data, especially molecular confirmation if available. The atlas is written in outline format for ease of use. Atlas of Genetic Diagnosis and Counseling, Third Edition is of great value to medical geneticists, genetic counselors, pediatricians, neonatologists, developmental pediatricians, perinatologists, obstetricians, neurologists, pathologists, and any physicians and health care professionals caring for handicapped children such as craniofacial surgeons, plastic surgeons, otolaryngologists, and orthopedists. It is the definitive volume for helping all physicians to understand and recognize genetic diseases and malformation syndrom es and better evaluate, counsel, and manage affected patients.
- Contents
- Acardia -- Achondrogenesis -- Achondroplasia -- Adams-Oliver Syndrome -- Agnathia -- Aicardi Syndrome -- Alagille Syndrome -- Albinism -- Alpha-Thalassemia X-linked Mental Retardation Syndrome -- Ambiguous Genitalia -- Amniotic Deformity, Adhesions, Mutilations (ADAM) Complex -- Androgen Insensitivity Syndrome -- Angelman Syndrome -- Apert Syndrome -- Aplasia Cutis Congenita -- Arthrogryposis Multiplex Congenita -- Asphyxiating Thoracic Dystrophy -- Ataxia-Telangiectasia -- Atelosteogenesis -- Autism -- Bannayan-Riley-Ruvalcaba Syndrome -- Beckwith-Wiedemann Syndrome -- Behcet Disease -- Biotinidase Deficiency -- Bladder Exstrophy -- Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome -- Body Stalk Anomaly -- Brachydactyly -- Branchial Cleft Anomalies -- Calcinosis Cutis -- Campomelic Dysplasia -- Carpenter Syndrome -- Cat Eye Syndrome -- Celiac Disease -- Cerebral Palsy -- Cerebro-Costo-Mandibular Syndrome -- Charcot-Marie-Tooth Disease -- CHARGE Syndrome -- Cherubism -- Chiari Malformation -- Chondrodysplasia Punctata -- Chromosome Abnormalities in Pediatric Solid Tumors -- Cleft Lip and/or Cleft Palate -- Cleidocranial Dysplasia -- Cloacal Exstrophy -- Clubfoot -- Collodion Baby -- Congenital Adrenal Hyperplasia -- Congenital Cutis Laxa -- Congenital Cytomegalovirus Infection -- Congenital Generalized Lipodystrophy -- Congenital Hemihyperplasia -- Congenital Hydrocephalus -- Congenital Hypothyroidism -- Congenital Muscular Dystrophy -- Congenital Toxoplasmosis -- Conjoined Twins -- Corpus Callosum Agenesis/Dysgenesis -- Craniometaphyseal Dysplasia -- Cri-Du-Chat Syndrome -- Crouzon Syndrome -- Cutaneous Vasculitis -- Cutis Marmorata Telangiectatica Congenita -- Cystic Fibrosis -- Dandy-Walker Malformation -- De Lange Syndrome -- Del(18p) Syndrome -- Del(22q11.2) Syndrome -- Del(Yq) Syndrome -- Diabetic Embryopathy -- Down Syndrome -- Duncan Syndrome -- Dyschondrosteosis -- Dysmelia -- Dysplasia Epiphysealis Hemimelica -- Dystonia -- Dystrophinopathies -- Ectrodactyly-Ectodermal Dysplasia-Clefting (EEC) Syndrome -- Ehlers-Danlos Syndrome -- Ellis-van Creveld Syndrome -- Enchondromatosis -- Epidermolysis Bullosa -- Epidermolytic Palmoplantar Keratoderma -- Faciogenital (Faciodigitogenital) Dysplasia -- Facioscapulohumeral Muscular Dystrophy -- Familial Adenomatous Polyposis -- Familial Hyperlysinemia -- Familial Mediterranean Fever -- Familial Patella Instability -- Familial Spastic Paraplegia -- Fanconi Anemia -- Feingold Syndrome -- Femoral Hypoplasia - Unusual Facies Syndrome -- Fetal Akinesia Deformation Sequence -- Fetal Alcohol Spectrum Disorders -- Fetal Hydantoin Syndrome -- Fibrodysplasia Ossificans Progressiva -- Fibular Hemimelia -- Finlay-Marks Syndrome -- Floppy Infant -- Fragile X Syndrome -- Fraser Syndrome -- Freeman-Sheldon Syndrome -- Friedreich Ataxia -- Frontonasal Dysplasia -- Galactosemia -- Gastroschisis -- Gaucher Disease -- Generalized Arterial Calcification of Infancy -- Genitopatellar Syndrome -- Giant Congenital Melanocytic Nevi -- Gilbert Syndrome -- Glucose-6-Phosphate Dehydrogenase Deficiency -- Glycogen Storage Disease, Type 2 -- Goldenhar Syndrome -- Gorlin Syndrome -- Greig Cephalopolysyndactyly Syndrome -- Growth Hormone Deficiency -- Hallermann-Streiff Syndrome -- Harlequin Ichthyosis -- Hemangiomas of Infancy -- Hemophilia A -- Hereditary Hearing Loss -- Hereditary -- Hemochromatosis -- Hereditary Multiple Exostoses -- Hereditary Sensory and Autonomic Neuropathies -- Herlyn-Werner-Wunderlich Syndrome -- Holoprosencephaly -- Holt-Oram Syndrome -- Huntington Disease -- Hydranencephaly -- Hydrolethalus Syndrome -- Hydrops Fetalis -- Hyper-IgE Syndrome -- Hypertrophic Cardiomyopathy (HCM) -- Hypochondroplasia -- Hypoglossia-Hypodactylia Syndrome -- Hypohidrotic Ectodermal Dysplasia -- Hypomelanosis of Ito -- Hypophosphatasia -- Hypopituitarism -- I(1p), I(1q) Syndrome -- Idic(Yq) Syndrome -- Incontinentia Pigmenti -- Infantile Myofibromatosis -- Ivemark Syndrome -- Jarcho-Levin Syndrome -- Joubert Syndrome -- Kabuki Syndrome -- Kasabach-Merritt Syndrome -- KID Syndrome -- Klinefelter Syndrome -- Klippel-Feil Syndrome -- Klippel-Trenaunay Syndrome -- Kniest Dysplasia -- Larsen Syndrome -- LEOPARD Syndrome -- Lesch-Nyhan Syndrome -- Lethal Multiple Pterygium Syndrome -- Loeys-Dietz Syndrome -- Lowe Syndrome -- Lymphangiomas and Lymphangiomatosis -- M#xf6;bius Syndrome -- Macrodactyly -- Marfan Syndrome -- McCune-Albright Syndrome -- Meckel-Gruber Syndrome -- Megalencephalic Leukoencephalopathy with Subcortical Cysts -- Menkes Disease -- Metachromatic Leukodystrophy -- Miller-Dieker Syndrome -- Mitochondrial Leber Hereditary Optic Neuropathy -- Mitochondrial Myopathy -- Mowat-Wilson Syndrome -- Mucolipidosis 2 -- Mucolipidosis 3 -- Mucopolysaccharidosis 1 (MPS 1) -- Mucopolysaccharidosis 2 -- Mucopolysaccharidosis 3 -- Mucopolysaccharidosis 4 -- Mucopolysaccharidosis 6 -- Multiple Endocrine Neoplasia Syndromes -- Multiple Epiphyseal Dysplasia -- Multiple Pterygium Syndrome -- Myotonic Dystrophy Type 1 -- Nager Acrofacial Dysostosis -- Nail-Patella Syndrome -- Nasal Obstruction in Neonates and Children -- Neonatal Herpes Simplex Infection -- Nephrogenic Diabetes Insipidus -- Netherton Syndrome -- Neu-Laxova Syndrome -- Neural Tube Defects -- Neurofibromatosis 1 -- Neurofibromatosis 2 -- Niemann-Pick Disease -- Noonan Syndrome -- Oblique Facial Cleft Syndrome -- Oligohydramnios Sequence -- Omphalocele -- Opitz Trigonocephaly (C) Syndrome -- Oral-Facial-Digital Syndrome -- Osteogenesis Imperfecta -- Osteogenesis Imperfecta Ehlers-Danlos Overlap Syndrome -- Osteopetrosis -- Osteopoikilosis -- Otopalatodigital Spectrum Disorders -- Pachyonychia Congenita -- Pallister-Killian Syndrome -- Peutz-Jeghers Syndrome -- Phenylketonuria -- Pierre Robin Sequence -- Polycystic Kidney Disease, Autosomal Dominant Type -- Polycystic Kidney Disease: Autosomal Recessive Type -- Popliteal Pterygium Syndrome -- Prader-Willi Syndrome -- Primary Microcephaly -- Progeria -- Prune Belly Syndrome -- Pseudoachondroplasia -- R(18) Syndrome -- Radioulnar Synostosis -- Retinoid Embryopathy -- Rett Syndrome -- Rickets -- Rigid Spine Syndrome -- Roberts Syndrome -- Robinow Syndrome -- Rubinstein-Taybi Syndrome -- Saethre-Chotzen Syndrome -- Sagittal Craniosynostosis Associated with Chromosome Abnormalities with a Brief Review on Craniosynostosis -- Schizencephaly Schmid Metaphyseal Chondrodysplasia -- Seckel Syndrome -- Severe Combined Immune Deficiency -- Short Rib-Polydactyly Syndromes -- Sickle Cell Disease -- Silver-Russell Syndrome -- Sirenomelia -- Smith-Lemli-Opitz Syndrome -- Smith-Magenis Syndrome -- Sotos Syndrome -- Spinal Muscular Atrophy -- Spondyloepiphyseal Dysplasia -- Stickler Syndrome -- Sturge-Webber Syndrome -- Symphalangism -- Tay-Sachs Disease -- Tetrasomy 9p Syndrome -- Thalassemia -- Thanatophoric Dysplasia -- Thrombocytopenia-Absent Radius Syndrome -- Treacher-Collins Syndrome -- Trimethylaminuria -- Triploidy -- Trismus-Pseudocamptodactyly Syndrome -- Trisomy 13 Syndrome -- Trisomy 18 Syndrome -- Trisomy 8 Mosaicism Syndrome -- Tuberous Sclerosis -- Turner Syndrome -- Twin-Twin Transfusion Syndrome -- Tyrosinemia -- Ulnar-Mammary Syndrome -- Urofacial Syndrome -- VATER (VACTERL) Association -- Von Hippel-Lindau Disease -- Waardenburg Syndrome -- Weill-Marchesani Syndrome -- Williams Syndrome -- Winchester syndrome -- Wolf-Hirschhorn Syndrome -- X-Linked Agammaglobulinemia -- X-Linked Ichthyosis -- XX Male -- XXX Syndrome -- XXXXX Syndrome -- XXXXY Syndrome -- XY Female -- XYY Syndrome.
- Format
- e-Book
- Publication Type
- Encyclopedia
- Location
- Online
Atlas of the Patellofemoral Joint
https://libcat.nshealth.ca/en/permalink/provcat32350
Vicente Sanchis-Alfonso, editor.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The Atlas of the Patellofemoral Joint is designed to be a detailed visual guide, presenting the reader with a wealth of images that will act as a crucial aid when faced with surgery of the knee and particularly that of the patella. All the images, footnotes and summaries are compiled in order to convey a simple understanding of this complex problem. It is a very practical book, aimed not only to those that already specialize in knee surgery, but also to the general orthopedic surgeon who wishes…
- Available Online
- View e-Book
- Other Authors
- Sanchis-Alfonso, Vicente
- Responsibility
- Vicente Sanchis-Alfonso, editor
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xxii, 262 p. : 352 ill., 68 ill. in color)
- ISBN
- 9781447144953
- Subjects (MeSH)
- Patellofemoral Joint - Atlases
- Joint Diseases - Atlases
- Subjects (LCSH)
- Orthopedics
- Orthopedic surgery
- Notes
- Originally published as part of Anterior Knee Pain and Patellar Instability, 2nd ed., 2011.
- Abstract
- The Atlas of the Patellofemoral Joint is designed to be a detailed visual guide, presenting the reader with a wealth of images that will act as a crucial aid when faced with surgery of the knee and particularly that of the patella. All the images, footnotes and summaries are compiled in order to convey a simple understanding of this complex problem. It is a very practical book, aimed not only to those that already specialize in knee surgery, but also to the general orthopedic surgeon who wishes to learn more about this particular form of surgery.
- Contents
- Part I: Etiopathogenic Bases and Therapeutic Implications -- 1. Background: Patellofemoral Malalignment Versus Tissue Homeostasis -- 2. In Search of the Etiology of Anterior Knee Pain -- 3. Biological Causes of Anterior Knee Pain -- 4. Pathogenesis of Anterior Knee Pain in the Active Young: Is There a Relation Between the Presence of Patellofemoral Malalignment and Pain? -- 5. Unilateral Anterior Knee Pain as a Sign of Knee Asymmetry -- 6. Biomechanical Bases for Anterior Knee Pain and Patellar Instability -- 7. Anatomy of Patellar Dislocation -- 8. Evaluation of the Patient with Anterior Knee Pain and Patellar Instability -- 9. Influence of Psychological Factors on Pain and Disability in Anterior Knee Pain Patients -- 10. Uncommon Causes of Anterior Knee Pain -- 11. Risk Factors and Prevention of Anterior Knee Pain -- 12. Non-operative Treatment of Athletes with Anterior Knee Pain: Science, Classical, and New Ideas -- 13. Conservative Management of Anterior Knee Pain: The McConnell Program -- 14. Skeletal Malalignment and Anterior Knee Pain: Rationale, Diagnosis, and Management -- 15. Biochemical Causes of Patellar Tendinopathy? -- 16. Prevention of Anterior Knee Pain After Anterior Cruciate Ligament Reconstruction -- 17. Anterior Knee Pain with Special Emphasis on the Clinical, Radiographic, Histological, Ultrastructural, and Biochemical Aspects After Anterior Cruciate Ligament Reconstruction Using Autografts -- Part II: Emerging Technologies for Investigating Patellofemoral Joint. Clinical Relevance -- 18. Imaging and Musculoskeletal Modeling to Investigate the Mechanical Etiology of Patellofemoral Pain -- 19. Computational Models for Investigating the Patellofemoral Joint: Clinical Relevance -- 20. Kinetic Analysis: A Sensitive Outcome Objective Measurement Method in Evaluating Lateral Patellar Instability -- 21. Kinetic and Kinematic Analysis in Evaluating Patients with Anterior Knee Pain -- Part III: Clinical Cases Commented -- 22. Failure of Patellofemoral Surgery: Analysis of Clinical Cases -- 23. Neuromatous Knee Pain: Evaluation and Management -- 24. Kinetic and Kinematic Analysis of Iatrogenic Medial Patellar Instability: Clinical Relevance -- Part IV: Surgical Techniques "How I Do It" -- 25. Ultrasound and Doppler-Guided Arthroscopic Shaving for the Treatment of Patellar Tendinopathy/Jumper’s Knee: Biological Background and Description of Method -- 26. Arthroscopic Patellar Denervation for Anterior Knee Pain -- 27. Reconstruction of the Medial Patellofemoral Ligament: How I Do It -- 28. Reconstruction of the Medial Patellofemoral Ligament: How I Do It -- 29. MPFL Reconstruction: Principles and Complications -- 30. Reconstruction of the Lateral Patellofemoral Ligament: How I Do It -- 31. Reconstruction of the Lateral Patellofemoral Ligament: How I Do It -- 32. Osteotomies Around the Patellofemoral Joint -- 33. Sulcus Deepening Trochleoplasty -- 34. Rotational Tibial Osteotomy -- 35. Rotational Femoral Osteotomy -- 36. Patella Infera and Patella Alta -- 37. Anteromedial Tibial Tubercle Osteotomy (Fulkerson Osteotomy) -- 38. Patella Thinning Osteotomy: A New Technique for Patellofemoral Arthritis -- 39. Cartilage Restoration in the Patellofemoral Joint -- 40. Autologous Osteochondral Mosaicplasty -- 41. Patellofemoral Allografts -- 42. Patellofemoral Arthroplasty: Pearls and Pitfalls -- 43. Patellofemoral Arthroplasty: The Great Solution, the Great Problem -- 44. Philosophy of the Patellofemoral Joint: A Logical Clinical Approach.
- Format
- e-Book
- Location
- Online
Atlas of Thyroid and Neuroendocrine Tumor Markers
https://libcat.nshealth.ca/en/permalink/provcat43325
Luca Giovanella, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is es…
- Available Online
- View e-Book
- Other Authors
- Giovanella, Luca
- Responsibility
- Luca Giovanella, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 249 p.) : 41 illus., 30 illus. in color
- ISBN
- 9783319625065
- 9783319625058 (print ed.)
- 9783319625072 (print ed.)
- 9783319873305 (print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Neuroendocrine Tumors - diagnosis
- Neuroendocrine Tumors - therapy
- Thyroid Neoplasms - diagnosis
- Thyroid Neoplasms - therapy
- Specialty
- Endocrinology
- Medical Oncology
- Abstract
- This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments.
- Contents
- Part I. Pathology and Pathobiology -- 1. Pathology and Immunohistochemistry in Thyroid Tumors -- 2. Pathology of Neuroendocrine Neoplasms: Morphological, Immunophenotypical, and Circulating Molecular Markers -- 3. Circulating Biomarkers: Biological Basis, Methods, and Interpretation Criteria -- Part II. Differentiated Thyroid Cancer -- 4. Differentiated Thyroid Cancer: Diagnosis, Therapy, and Follow-Up -- 5. Thyroglobulin and Thyroglobulin Antibodies -- 6. Circulating Molecular Biomarkers in Thyroid Cancer -- 7. Circulating Epithelial Tumor Cells in Thyroid Carcinoma -- Part III. Medullary Thyroid Carcinoma -- 8. Medullary Thyroid Carcinoma (MTC): Diagnosis, Treatment and Follow-Up -- 9. Calcitonin and Carcinoembryonic Antigen for the Diagnosis and Management of Medullary Thyroid Carcinoma -- 10. Procalcitonin: Are We Ready for Clinical Use? -- Part IV. Aggressive and Rare Thyroid Carcinoma -- 11. Aggressive Variants of Thyroid Carcinoma -- 12. Circulating Mucins and Cytokeratins in Aggressive Thyroid Cancers -- Part V. Thyroid Biomarkers on Fine-Needle Washouts -- 13. Measurement of Thyroid Tumor Markers on Fine-Needle Washouts -- Part VI. Neuroendocrine Tumors -- 14. Neuroendocrine Tumours: Diagnosis, Therapy and Follow-up -- 15. Circulating Markers in Neuroendocrine Tumors -- 16. Neuroendocrine Gene Transcripts: The Role of Molecular Biomarkers in Diagnosis and Management.
- Format
- e-Book
- Publication Type
- Atlas
- Location
- Online
Biochemistry, cell and molecular biology, and genetics : an integrated textbook
https://libcat.nshealth.ca/en/permalink/provcat46241
Zeynep Gromley, Adam Gromley.
--New York, NY:
Thieme
, c2020.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Gromley, Zeynep
- Responsibility
- Zeynep Gromley, Adam Gromley
- Place of Publication
- New York, NY
- Publisher
- Thieme
- Date of Publication
- c2020
- Physical Description
- 1 online resource
- ISBN
- 9781626235359
- Subjects (MeSH)
- Biochemical Phenomena
- Genetic Phenomena
- Specialty
- Biochemistry
- Format
- e-Book
- Publication Type
- Examination Questions
- Outline
- Location
- Online
Biochemistry for Anesthesiologists and Intensivists
https://libcat.nshealth.ca/en/permalink/provcat45100
Fernando Alemanno, editor.
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This book discusses and explains the importance of biochemistry knowledge in understanding what happens to patients during anesthesia and/or to those being in intensive care. Anesthesiological and intensive care practice require a detailed biochemistry knowledge to avoid onset of complications and/or to deal with unexpected events promptly and appropriately. The book is intended for anesthesiologists, intensivists, anesthesia teachers, anesthesia trainees and residents.
- Available Online
- View e-Book
- Other Authors
- Alemanno, Fernando
- Responsibility
- Fernando Alemanno, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (xiv, 250 p.) : 65 illus., 22 illus. in color
- ISBN
- 9783030267216
- 9783030267209 (Print ed.)
- 9783030267223 (Print ed.)
- 9783030267230 (Print ed.)
- Subjects (MeSH)
- Anesthesia
- Anesthetics - adverse effects
- Anesthetics - pharmacology
- Biochemical Phenomena
- Critical Care
- Specialty
- Anesthesiology
- Biochemistry
- Abstract
- This book discusses and explains the importance of biochemistry knowledge in understanding what happens to patients during anesthesia and/or to those being in intensive care. Anesthesiological and intensive care practice require a detailed biochemistry knowledge to avoid onset of complications and/or to deal with unexpected events promptly and appropriately. The book is intended for anesthesiologists, intensivists, anesthesia teachers, anesthesia trainees and residents.
- Contents
- 1. Enzymes and Coenzymes (A Brief, Boring but Necessary Preamble) -- 2. Anaerobic Glycolysis or Embden–Meyerhof Pathway -- 3. Tricarboxylic Acids Cycle or Krebs Cycle -- 4. Glutamate – GABA Collateral Cycle -- 5. Hexose-Monophosphate Shunt or Horecker Cycle (The Sleep Pathway) -- 6. Neurotransmitters -- 7. The Blood-Brain Barrier (BBB) -- 8. Shock -- 9. Cerebral Edema -- 10. The Pulmonary Surfactant -- 11. When the Mind Does Not Work As It Should -- 12. Thiamine (Vitamin B1) -- 13. Normobaric Oxygen Therapy (NBO) -- 14. Acid-Base Equilibrium -- 15. Theories of Narcosis -- 16. Local Anaesthetics -- 17. Perineural Adjuvants -- 18. The Grand Design -- 19. Epilogue and Farewell.
- Format
- e-Book
- Location
- Online
Biomarkers of kidney disease
https://libcat.nshealth.ca/en/permalink/provcat31569
edited by Charles L. Edelstein.
(2nd ed.)
--Amsterdam, Netherlands:
Elsevier
, c2017.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Edelstein, Charles L
- Responsibility
- edited by Charles L. Edelstein
- Edition
- 2nd ed.
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Elsevier
- Date of Publication
- c2017
- Physical Description
- 1 online resource
- ISBN
- 9780128030141
- Subjects (MeSH)
- Kidney Diseases - diagnosis
- Biological Markers
- Subjects (LCSH)
- Kidney Diseases - diagnosis
- Biological Markers
- Kidneys - Diseases - Molecular diagnosis
- Biochemical markers
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Breastfeeding : a guide for the medical profession
https://libcat.nshealth.ca/en/permalink/provcat30745
edited by Ruth A Lawrence, Robert M Lawrence, Lawrence Noble ... [et al.].
(9th ed.)
--Philadelphia, PA:
Elsevier
, c2022.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
Written and edited by leading physicians, Breastfeeding: A Guide for the Medical Profession, 9th Edition, offers comprehensive, dependable information and guidance in this multifaceted field. Award-winning author and co-founder of the Academy of Breastfeeding Medicine, Dr. Ruth Lawrence, and her son, Dr. Rob Lawrence, ensure that you’re brought fully up to date on everything from basic data on the anatomical, physiological, biochemical, nutritional, immunological, and psychological aspects of …
- Available Online
- View e-Book
- Author
- Lawrence, Ruth A.
- Other Authors
- Lawrence, Robert M.
- Responsibility
- edited by Ruth A Lawrence, Robert M Lawrence, Lawrence Noble ... [et al.]
- Edition
- 9th ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Elsevier
- Date of Publication
- c2022
- Physical Description
- 1 online resource, 1088 p.
- ISBN
- 9780323680134
- Subjects (MeSH)
- Breast Feeding
- Lactation
- Milk, Human
- Specialty
- Nutritional Sciences
- Pediatrics
- Abstract
- Written and edited by leading physicians, Breastfeeding: A Guide for the Medical Profession, 9th Edition, offers comprehensive, dependable information and guidance in this multifaceted field. Award-winning author and co-founder of the Academy of Breastfeeding Medicine, Dr. Ruth Lawrence, and her son, Dr. Rob Lawrence, ensure that you’re brought fully up to date on everything from basic data on the anatomical, physiological, biochemical, nutritional, immunological, and psychological aspects of human lactation, to the problems of clinical management of breastfeeding-all in a highly readable, easily accessible desk reference.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Breath Odors : Origin, Diagnosis, and Management
https://libcat.nshealth.ca/en/permalink/provcat45350
Nir Sterer, Mel Rosenberg.
(Second edition)
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Location
- Online
This comprehensive, evidence-based textbook presents the latest knowledge on bad breath, describing insights from basic research and offering expert guidance on current approaches to diagnosis and treatment. The new edition has been thoroughly updated to take account of recent advances in understanding. The opening chapters examine in detail the origins of bad breath, including from the nose and pharynx. Microbial and biochemical aspects are fully explained, and information is also provided on …
- Available Online
- View e-Book
- Author
- Sterer, Nir
- Other Authors
- Rosenberg, Mel
- Responsibility
- Nir Sterer, Mel Rosenberg
- Edition
- Second edition
- Alternate Title
- Breath odours
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Physical Description
- 1 online resource (vii, 104 p.) : 13 illus., 12 illus. in color
- ISBN
- 9783030447311
- 9783030447304 (Print ed.)
- 9783030447328 (Print ed.)
- 9783030447335 (Print ed.)
- Subjects (MeSH)
- Halitosis - diagnosis
- Halitosis - etiology
- Halitosis - therapy
- Subjects (LCSH)
- Dentistry
- Abstract
- This comprehensive, evidence-based textbook presents the latest knowledge on bad breath, describing insights from basic research and offering expert guidance on current approaches to diagnosis and treatment. The new edition has been thoroughly updated to take account of recent advances in understanding. The opening chapters examine in detail the origins of bad breath, including from the nose and pharynx. Microbial and biochemical aspects are fully explained, and information is also provided on odor perception. The clinically focused chapters cover all forms of laboratory measurement of breath odors, chairside diagnostic techniques, and the full range of available treatment options. The value of self-administered questionnaires in assessing bad breath is discussed, and attention is paid to the problem in specific population groups and to psychological aspects. Finally, future prospects are reviewed. The authors draw on more than forty years of combined experience in the field, both in the laboratory and as consultants to thousands of patients. The book will be of interest to all dentists as well as ENT specialists and family physicians.
- Contents
- 1. Introduction -- 2. Breath Odors of Oral Origin (Oral Malodor) -- 3. Biochemical and Microbial Aspects of Oral Malodor Production -- 4. Odor Perception -- 5. Breath Odors of Nasal and Pharyngeal Origin -- 6. Breath Odors and the Gastrointestinal Tract -- 7. Other Sources of Breath Odors -- 8. Measurements of Breath Odors and Related Parameters -- 9. Breath Odor Diagnosis -- 10. Self-Assessment of Breath Odors -- 11. Breath Odors, Prevalence, Gender, and Age -- 12. Psychological Aspects of Breath Odors -- 13. Oral Malodor Management -- 14. History of Breath Odors -- 15. Future Prospects.
- Format
- e-Book
- Location
- Online
Cadmium Toxicity : New Aspects in Human Disease, Rice Contamination, and Cytotoxicity
https://libcat.nshealth.ca/en/permalink/provcat44135
Seiichiro Himeno, Keiko Aoshima, editors.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pa…
- Available Online
- View e-Book
- Other Authors
- Himeno, Seiichiro
- Aoshima, Keiko
- Responsibility
- Seiichiro Himeno, Keiko Aoshima, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 190 p.) : 68 illus., 51 illus. in color
- Series
- Current Topics in Environmental Health and Preventive Medicine
- ISBN
- 9789811336300
- 9789811336294 (Print ed.)
- 9789811336317 (Print ed.)
- ISSN
- 2364-8333
- Subjects (MeSH)
- Cadmium - toxicity
- Cadmium Poisoning
- Environmental Exposure
- Food Contamination - prevention & control
- Specialty
- Toxicology
- Abstract
- This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium: New Aspects in Human Disease, Rice Contamination, and Cytotoxicity is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.
- Contents
- Part I. Overview -- 1. Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation -- Part II. Health Effects of Cadmium in Human Populations and its Relation to Cadmium Exposure Levels -- 2. Recent Clinical and Epidemiological Studies of Itai-Itai Disease (Cadmium-Induced Renal Tubular Osteomalacia) and Cadmium Nephropathy in the Jinzu River Basin in Toyama Prefecture, Japan -- 3. Novel Pathological Study of Cadmium Nephropathy of Itai-itai Disease -- 4. Long-Term Follow-Up Study of Residents Exposed to Cadmium in Kakehashi River Basin, Ishikawa, Japan -- 5. Effects of Cadmium Exposure on Life Prognosis -- 6. Cadmium Exposure and Its Effects on the Health Status of Rice Farmers in Akita Prefecture 7. Dietary Cadmium Intake Among General Populations in Japan and East Asia -- Part III. Rice Contamination by Cadmium and its Remediation -- 8. Regulations for Cadmium in Rice and Soil in Japan and Countermeasures to Reduce the Concentrations -- 9. Molecular Mechanism of Cadmium Accumulation in Rice - 10. Mitigation Strategies for Cadmium and Arsenic in Rice -- 11. Development of Low-Cadmium-Accumulating Rice -- Part IV. New Aspects in the Mechanisms of Cadmium Toxicity -- 12. Novel Mechanisms of Cadmium-Induced Toxicity in Renal Cells - 13. Roles of Metal Transporters in Cellular Cadmium Transport in Mammals -- 14. Disturbance in Phosphorus Metabolism by Cadmium Exposure.
- Format
- e-Book
- Location
- Online
Color atlas of biochemistry
https://libcat.nshealth.ca/en/permalink/provcat33098
Jan Koolman, Klaus-Heinrich Roehm ; with 220 color plates prepared by Juergen Wirth.
(3rd ed., rev. and updated)
--Stuttgart:
Thieme
, c2013.
- Available Online
- View e-Book
- Location
- Online
Providing a powerful visual overview of the entire spectrum of human biochemistry, the third edition of the popular Color Atlas of Biochemistry is an ideal reference and study aid. It utilizes the signature Flexibook format, consisting of double-page spreads with clear explanatory text on the left-hand page and exquisitely detailed full-color graphics on the right. These bite-sized learning capsules ensure that your review of any given topic is quick, efficient, and comprehensive, allowing you …
- Available Online
- View e-Book
- Author
- Koolman, Jan
- Other Authors
- Röhm, Klaus-Heinrich
- Wirth, Juergen
- Responsibility
- Jan Koolman, Klaus-Heinrich Roehm ; with 220 color plates prepared by Juergen Wirth
- Edition
- 3rd ed., rev. and updated
- Alternate Title
- Colour atlas of biochemistry
- Biochemistry
- Place of Publication
- Stuttgart
- Publisher
- Thieme
- Date of Publication
- c2013
- Physical Description
- 1 online resource (ix, 495 p.)
- ISBN
- 9783131003737
- 9783131696939 (eISBN)
- Subjects (MeSH)
- Biochemical Phenomena - Atlases
- Biochemistry - Atlases
- Subjects (LCSH)
- Biochemical Phenomena - Atlases
- Biochemistry - Atlases
- Biochemistry - Handbooks, manuals, etc
- Specialty
- Biochemistry
- Abstract
- Providing a powerful visual overview of the entire spectrum of human biochemistry, the third edition of the popular Color Atlas of Biochemistry is an ideal reference and study aid. It utilizes the signature Flexibook format, consisting of double-page spreads with clear explanatory text on the left-hand page and exquisitely detailed full-color graphics on the right. These bite-sized learning capsules ensure that your review of any given topic is quick, efficient, and comprehensive, allowing you to target the exact information you need for classroom and exam success.
- Contents
- Basics -- Biomolecules -- Metabolism -- Cell organelles -- Molecular genetics -- Tissues and organs -- Nutrition -- Signalling systems -- Growth and development -- Appendix.
- Format
- e-Book
- Location
- Online
Comprehensive Biochemistry for Dentistry : Textbook for Dental Students
https://libcat.nshealth.ca/en/permalink/provcat44220
Anil Gupta.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitam…
- Available Online
- View e-Book
- Author
- Gupta, Anil
- Responsibility
- Anil Gupta
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xxxv, 604 p.) : 266 illus., 195 illus. in color
- ISBN
- 9789811310355
- 9789811310348 (Print ed.)
- 9789811310362 (Print ed.)
- Subjects (MeSH)
- Biochemical Phenomena
- Dentistry - education
- Specialty
- Biochemistry
- Dentistry
- Abstract
- This book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitamins and hormones, enriched with flow charts and diagrams for easy understanding and quick reference. It includes chapters on nucleic acids, nutrition and serum enzymes and organ function tests, and offers an innovative approach to familiarize dental students with the biochemical composition of enamel, dentine, cementum and saliva, explaining the biochemical basis of dental caries, periodontal diseases, role of fluorides in caries prophylaxis, fluoride toxicity, and the role of amino acids as anti-hypersensitive agents.
- Contents
- Introduction to Biochemistry -- Part I. Cellular Biochemistry -- Cell and Organelles -- Part II. Structural Biochemistry -- Proteins and Amino acids -- Plasma Proteins -- Haemoglobin -- Carbohydrates -- Lipids -- Nucleic Acids -- Enzymes -- Hormones -- Vitamins -- Part III. Metabolism -- Digestion and Absorption of Proteins -- Metabolism of Proteins and Amino acids -- Digestion and Absorption of Carbohydrates -- Metabolism of Carbohydrates -- Digestion and Absorption of Lipids -- Metabolism of Lipids -- Metabolism of Minerals -- Biological Oxidation -- Part IV. Medical Biochemistry -- Acid-Base Balance -- Nutrition -- Serum Enzymes and Organ Function Tests -- Part: V Immunochemistry -- Immunoglobulins -- Part V. Dental Biochemistry -- Dental Biochemistry.
- Format
- e-Book
- Location
- Online
Congenital Hyperinsulinism : A Practical Guide to Diagnosis and Management
https://libcat.nshealth.ca/en/permalink/provcat44051
Diva D. De León-Crutchlow, Charles A. Stanley, editors.
--Cham:
Humana Press
, 2019.
- Available Online
- View e-Book
- Location
- Online
This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a “personalized” approach to management according to the type of hyperinsulinism, and particularly according to the li…
- Available Online
- View e-Book
- Other Authors
- De León-Crutchlow, Diva D.
- Stanley, Charles A.
- Responsibility
- Diva D. De León-Crutchlow, Charles A. Stanley, editors
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xv, 165 p.) : 22 illus., 12 illus. in color
- Series
- Contemporary Endocrinology
- Series Title
- Contemporary endocrinology
- ISBN
- 9783030029616
- 9783030029609 (Print ed.)
- 9783030029623 (Print ed.)
- ISSN
- 2523-3785
- Specialty
- Diabetes Mellitus
- Abstract
- This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a “personalized” approach to management according to the type of hyperinsulinism, and particularly according to the likelihood of focal hyperinsulinism, is starting to emerge. The opening chapter discusses HI diagnosis using biochemical approaches and phenotype characterization. The various forms of HI are then presented in detail in three main categories: diazoxide-responsive, diazoxide-unresponsive and syndromic HI. Both medical and surgical management strategies are then discussed, covering imaging, histology, surgical approach, and post-operative management. Complications, such as feeding problems, and long-term outcomes, such as neurodevelopmental issues, are carefully considered in the final chapter. Practical and user-friendly, Congenital Hyperinsulinism is the go-to resource for pediatric endocrinologists, residents and fellows, general pediatricians and neonatologists.
- Contents
- Approach to the Diagnosis of Neonates and Infants with Persistent Hypoglycemia -- Diazoxide-Responsive Forms of Congenital Hyperinsulinism -- Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism -- Syndromic Causes of Congenital Hyperinsulinism -- Molecular Diagnosis of Congenital Hyperinsulinism -- Medical Management of Hyperinsulinism -- 18F-DOPA PET -- Histopathology of the Pancreas in Congenital Hyperinsulinism -- Surgery for Congenital Hyperinsulinism -- Perioperative Management of Hyperinsulinism -- Management of the Child with Persistent Hypoglycemia After Surgery -- Management of Diabetes and Pancreatic Insufficiency after Pancreatectomy -- Feeding Problems in Congenital Hyperinsulinism -- Neurodevelopmental Outcomes.
- Format
- e-Book
- Location
- Online
Diabetes & C-Peptide : Scientific and Clinical Aspects
https://libcat.nshealth.ca/en/permalink/provcat31009
Anders A.F. Sima, editor.
--New York, NY:
Humana Press
, c2012.
- Available Online
- View e-Book
- Location
- Online
In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, includ…
- Available Online
- View e-Book
- Other Authors
- Sima, Anders A.F
- Responsibility
- Anders A.F. Sima, editor
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xiii, 169 p. : 63 ill., 35 ill. in color)
- Series Title
- Contemporary diabetes
- ISBN
- 9781617793912
- Subjects (MeSH)
- C-Peptide - physiology
- C-Peptide - therapeutic use
- Diabetes Complications - prevention & control
- Diabetes Mellitus, Type 1 - drug therapy
- Subjects (LCSH)
- Diabetes
- Endocrinology
- Biochemistry
- Abstract
- In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide's physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.
- Contents
- C-peptide and Insulin: A Happy Marriage -- Peptide Interactions of Proinsulin C-peptide -- The Effect of Combined C-peptide and Zinc on Cellular Function -- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy -- Role of C-Peptide in the Regulation of Microvascular Blood Flow -- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy? -- Renoprotective Effects of C-Peptide in Type I Diabetes -- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy -- C-peptide and Type 1 Diabetic Encephalopathy -- C-peptide: a New Molecule with Anti-Inflammatory Properties -- C-peptide: Connecting Diabetes with Macrovascular Complications -- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes -- Proatherogenic Effects of C-Peptide -- Conclusions and Future Outlook.
- Format
- e-Book
- Location
- Online
