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Abdominal Neuroendocrine Tumors

https://libcat.nshealth.ca/en/permalink/provcat43267
Massimo Carlini, editor. --Milano: Springer , c2018.
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This book aims to equip readers with a better understanding of neuroendocrine tumors of the abdomen and explains how to manage them optimally by making use of novel therapeutic options that represent major advances on previous treatments. The most recent advances in epidemiology, genetics, molecular biology, biomarkers, pathology, diagnostics, clinical assessment, medical therapy, and surgical treatment are presented. The information and data provided will stimulate readers to develop their per…
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Other Authors
Carlini, Massimo
Responsibility
Massimo Carlini, editor
Place of Publication
Milano
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xvii, 198 p.) : 20 illus., 10 illus. in color
Series Title
Updates in surgery
ISBN
9788847039551
9788847039544 (print ed.)
9788847039568 (print ed.)
9788847039711 (print ed.)
ISSN
2280-9848
Subjects (MeSH)
Abdominal Neoplasms
Neuroendocrine Tumors
Specialty
Endocrinology
Neurology
Medical Oncology
Abstract
This book aims to equip readers with a better understanding of neuroendocrine tumors of the abdomen and explains how to manage them optimally by making use of novel therapeutic options that represent major advances on previous treatments. The most recent advances in epidemiology, genetics, molecular biology, biomarkers, pathology, diagnostics, clinical assessment, medical therapy, and surgical treatment are presented. The information and data provided will stimulate readers to develop their personal opinions on significant issues and assist in decision making in individual patients during routine clinical practice. The book features a multidisciplinary approach and is designed to meet the needs of all physicians seeking comprehensive guidance from experts on the management of patients with neuroendocrine tumors. It will also be of value for researchers wishing to acquaint themselves with the state of the art in the field and emerging research avenues. Abdominal Neuroendocrine Tumors is published in Springer's highly successful Updates in Surgery series, which now comprises more than 20 titles.
Contents
Part I. Nosography -- 1. Neuroendocrine Tumors: a Nosologic Framework -- 2. Classification of Abdominal Neuroendocrine Tumors -- 3. Hereditary Syndromes and Abdominal Neuroendocrine Tumors -- 4. Sporadic Gastroenteropancreatic Neuroendocrine Tumors -- Part II. Diagnosis -- 5. Neuroendocrine Tumors Biomarkers -- 6. Endoscopic Diagnosis of Gastrointestinal and Pancreatic Neuroendocrine Tumors -- 7. Role of Non-Functional Imaging in the Diagnosis of Abdominal Neuroendocrine Tumors -- 8. Role of Functional Imaging in the Diagnosis of Neuroendocrine Tumors -- 9. Pathological Analysis of Abdominal Neuroendocrine Tumors -- Part III. Management -- 10. Management of Gastric Neuroendocrine Tumors -- 11. Management of Pancreatic and Duodenal Neuroendocrine Tumors -- 12. Management of Ileal, Appendiceal and Colorectal Neuroendocrine Tumors -- 13. Management of Liver Metastases from Gastroenteropancreatic Neuroendocrine Tumors.
Format
e-Book
Location
Online
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The ACL Handbook : Knee Biology, Mechanics, and Treatment

https://libcat.nshealth.ca/en/permalink/provcat40712
Martha M. Murray, Patrick Vavken, Braden C. Fleming, editors. --New York, NY: Springer , c2013.
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ACL injuries affect the lives of hundreds of thousands of people each year. Treatment is far from perfect, and physicians and patients face challenges such as high failure rates in adolescent athletes and the inability to slow the accelerated progression of arthritis after an ACL rupture, for example. The ACL Handbook takes a complete view of ACL injuries and treatments, discussing: Normal ACL and knee mechanics; The body's response to ACL injury; Development of new treatment methods. Ideal for…
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Murray, Martha M
Vavken, Patrick
Fleming, Braden C
Responsibility
Martha M. Murray, Patrick Vavken, Braden C. Fleming, editors
Alternate Title
Anterior cruciate ligament handbook
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xi, 317 p. : ill.)
ISBN
9781461407607
9781461407591 (print ed.)
Subjects (MeSH)
Anterior Cruciate Ligament - injuries
Anterior Cruciate Ligament Reconstruction - methods
Models, Biological
Tissue Engineering
Wound Healing - physiology
Abstract
ACL injuries affect the lives of hundreds of thousands of people each year. Treatment is far from perfect, and physicians and patients face challenges such as high failure rates in adolescent athletes and the inability to slow the accelerated progression of arthritis after an ACL rupture, for example. The ACL Handbook takes a complete view of ACL injuries and treatments, discussing: Normal ACL and knee mechanics; The body's response to ACL injury; Development of new treatment methods. Ideal for orthopedists, sports medicine physicians, and physical therapists, The ACL Handbook is a unique resource for information on the basic and applied science of ACL injury, repair, and the future of treatment.
Contents
Part I. ACL Injury: The Clinical Problem -- ACL Injury Epidemiology -- History of ACL Treatment and Current Gold Standard of Care -- ACL Clinical Outcomes -- ACL Treatment in the Skeletally Immature Patient -- Part II. ACL Injury: The Biologic Problem -- The Biology of the Normal ACL -- The Role of Inflammation and Blood Cells in Wound Healing -- The ACL Response to Injury -- The Biology of Impaired Healing of Joint Issues -- Part III. Translational Medicine: In Vitro and In Vivo Models -- Translational Medicine -- In Vitro Models of ACL Injury -- In Vivo Models of ACL Injury (Central Defect, Porcine, Ovine, Canine) -- Tissue Engineering of Ligaments and Tendons -- Outcome Assessment for ACL Tissue Engineering -- Part IV. Stimulating Healing of the ACL Using Tissue Engineering -- Scaffolds and Biologic Additives for ACL Surgery -- Use of Biologics to Treat Partial ACL Tears -- Can We Get a Complete ACL Tear to Heal? -- The Effects of Platelets and Their Concentration on ACL Healing -- The Effects of WBCs and RBCs on Ligament Healing -- Safety of the Bioenhanced Repair -- Re-Innervation and Revascularization in Engineered ACL Healing -- Bio-enhancement of ACL Graft Healing -- The Effects of Age and Skeletal Maturity on Healing of the Anterior Cruciate Ligament.
Format
e-Book
Location
Online
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Stefan H. Faderl, Hagop M. Kantarjian, Elihu Estey, editors. (Second edition) --Cham: Springer , c2021.
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NEW Springer 2021
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The new edition of this well-received book provides a timely update of current knowledge on the biology, disease classification, and treatment of the acute leukemias – acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Throughout, the focus is on the provision of state of the art information and guidance that will meet the needs of clinicians. Chapters have been extensively revised to take into account advances in understanding and management that have been achieved over the p…
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Faderl, Stefan H.
Kantarjian, Hagop M.
Estey, Elihu
Responsibility
Stefan H. Faderl, Hagop M. Kantarjian, Elihu Estey, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (vi, 289 p.) : 30 illus., 23 illus. in color
Series Title
Hematologic Malignancies
ISBN
9783030536336
9783030536329 (Print ed.)
9783030536343 (Print ed.)
9783030536350 (Print ed.)
ISSN
2197-9766
Subjects (MeSH)
Leukemia, Myeloid, Acute
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Specialty
Hematology
Medical Oncology
Abstract
The new edition of this well-received book provides a timely update of current knowledge on the biology, disease classification, and treatment of the acute leukemias – acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Throughout, the focus is on the provision of state of the art information and guidance that will meet the needs of clinicians. Chapters have been extensively revised to take into account advances in understanding and management that have been achieved over the past few years. In addition, new chapters have been included on selection of AML patients for therapy, a broader discussion of stem cell transplantation in AML, the role of immunotherapy in ALL, the approach to newly diagnosed pediatric ALL, and the diagnosis and management of BCR-ABL-like ALL. New therapies, including investigational ones, are fully covered. As progress continues in the management of acute leukemias this book will be a valuable asset for clinicians at all levels of experience.
Contents
Part I. Acute Myeloid Leukemia -- 1. Acute Myeloid Leukemia: Epidemiology and Etiology -- 2. Clinical Presentation, Diagnosis, and Classification of Acute Myeloid Leukemia -- 3. Insights into the Pathobiology of Secondary AML -- 4. Selection of Patients for Individual Acute Myeloid Leukemia Therapies -- 5. Therapy of Newly Diagnosed Acute Myeloid Leukemia (AML) -- 6. Management of Relapsed/Refractory Acute Myeloid Leukemia -- 7. The Role of Stem Cell Transplant in the Therapy of Acute Myeloid Leukemia (AML) -- 8. Novel and Investigational Therapies in Acute Myeloid Leukemia -- 9. Immune-Based Approaches in AML -- Part II. Acute Lymphoblastic Leukemia -- 10. Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification -- 11. Frontline Therapy of Newly Diagnosed Acute Lymphoblastic Leukemia -- 12. Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents -- 13. Hematopoietic Cell Transplantation (HCT) for Acute Lymphoblastic Leukemia (ALL) -- 14. Minimal or Measurable Residual Disease in Acute Lymphoblastic Leukemia -- 15. Management of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia -- 16. Ph-Like ALL: Diagnosis and Management -- 17. Adult Burkitt Leukemia/Lymphoma -- 18. Management of Relapsed and Refractory ALL.
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NEW Springer 2021
Format
e-Book
Location
Online
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Acute myelogenous leukemia : genetics, biology and therapy

https://libcat.nshealth.ca/en/permalink/provcat30141
--New York, NY: Springer-Verlag , c2010.
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Online
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Other Authors
Nagarajan, Lalitha
Place of Publication
New York, NY
Publisher
Springer-Verlag
Date of Publication
c2010
Series Vol.
145
Series Title
Cancer treatment and research
ISBN
9780387692593
Subjects (MeSH)
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - therapy
Subjects (LCSH)
Hematology
Oncology
Format
e-Book
Location
Online
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Acute Promyelocytic Leukemia : A Clinical Guide

https://libcat.nshealth.ca/en/permalink/provcat42873
edited by Oussama Abla, Francesco Lo Coco, Miguel A. Sanz. --Cham: Springer , c2018.
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This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and ch…
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Abla, Oussama
Lo Coco, Francesco
Sanz, Miguel A.
Responsibility
edited by Oussama Abla, Francesco Lo Coco, Miguel A. Sanz
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 274 p.) : 39 illus., 29 illus. in color
ISBN
9783319642574
9783319642567 (print ed.)
9783319642581 (print ed.)
9783030097134 (print ed.)
Subjects (MeSH)
Leukemia, Promyelocytic, Acute
Specialty
Hematology
Medical Oncology
Abstract
This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges. Written by top experts in the field,áAcute Promyelocytic Leukemia: A Clinical Guideáis a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.
Contents
History of APL -- Molecular Targets of Treatment in APL -- The Leukemic Stem Cell -- The Molecular Genetics of APL -- APL Coagulopathy -- Early Death in APL -- Prognostic Factors in APL -- First-line therapy for APL: Chemotherapy-based approach -- First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach -- Cure of APL without Chemotherapy -- Minimal Residual Disease in APL -- Treatment of refractory and relapsed APL -- Hematopoietic Stem Cell Transplantation in APL -- APL in Children -- Management of APL in the Elderly -- Special Situations in APL -- APL in Developing Countries: A Chemotherapy-Based Approach -- APL in Developing Countries: ATO based Approach -- Therapy-Related APL -- Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes -- Management of Treatment-Related Complications in APL.
Format
e-Book
Location
Online
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Acute respiratory distress syndrome

https://libcat.nshealth.ca/en/permalink/provcat24336
Choi, Augustine MK. (2nd ed.) --New York, NY: Informa Healthcare , 2010.
Call Number
WF 140 A189 2010
Location
Dickson Building
Call Number
WF 140 A189 2010
Author
Choi, Augustine MK
Edition
2nd ed.
Place of Publication
New York, NY
Publisher
Informa Healthcare
Date of Publication
2010
Physical Description
458 p.
Series Vol.
v. 233
Series Title
Lung biology in health and disease
ISBN
9781420088403
Subjects (MeSH)
Respiratory Distress Syndrome, Adult
Systemic inflammatory response syndrome
Format
Book
Location
Dickson Building
Loan Period
3 weeks
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Adenocarcinoma of the Esophagogastric Junction : From Barrett's Esophagus to Cancer

https://libcat.nshealth.ca/en/permalink/provcat41294
Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni, editors. --Cham: Springer , 2017.
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This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical…
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Giacopuzzi, Simone
Zanoni, Andrea
de Manzoni, Giovanni
Responsibility
Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xv, 280 pages) : 74 illus., 62 illus. in color
ISBN
9783319287768
9783319287744 (print ed.)
Subjects (MeSH)
Adenocarcinoma - diagnosis
Adenocarcinoma - therapy
Barrett Esophagus - surgery
Esophagogastric Junction
Abstract
This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical atlas documenting the techniques used in the EGJ region, with superb color images and stepwise description of procedures. Against the background of the rapidly increasing incidence in EGJ cancer, especially evident in Western countries, there is a need for greater uniformity in management strategies, which currently vary significantly across the world. This book provides appropriate guidance that will assist all practitioners involved in the diagnosis and treatment of EGJ cancers, including surgeons, oncologists, and radiotherapists.
Contents
1. Epidemiology and risk factors -- 2. Barrett's esophagus: pathogenesis and prevention -- 3. Surveillance in Barrett's esophagus and dysplasia -- 4. Ablation techniques for Barrett's esophagus and dysplasia -- 5. Endoscopic resection for Barrett's esophagus and dysplasia -- 6. 7th Edition AJCC/UICC Staging: Esophagus and Esophagogastric Junction -- 7. Siewert Classification of Adenocarcinoma of the Esophagogastric Junction: still in or already out ? -- 8. Preoperative work- up: conventional radiology, ultrasonography, CT scan and MRI -- 9. Role of PET/CT and MRI in the prediction of response to neoadjuvant treatment -- 10. Molecular biology in the prediction of response to neoadjuvant treatment -- 11. Pathological response to neoadjuvant treatment: more questions than answers -- 12. Hospital volume and centralization in EGJ cancer -- 13. Patient selection and tailored treatment principles -- 14. How to treat EGJ cancer: indications and treatment strategy -- 15. Chemotherapy in EGJ cancer -- 16. Chemoradiation in EGJ cancer -- 17. Signet ring carcinoma in EGJ: what is it? -- 18. Morbid-mortality and treatment of complications -- 19. Long term results in surgery alone and multimodal treatments -- 20. Open or minimally invasive? Comparison of early and late results -- 21. Enhanced Recovery After Surgery (ERAS and nutritional aspects -- 22. Unresectable and metastatic cancer -- 23. Recurrence: treatment or just palliation? -- 24. Follow-up and quality of life -- 25. Surgical anatomy of esophagus and esophagogastric junction -- 26. Surgical technique: open procedures -- 27. Surgical technique: minimally invasive procedures.
Format
e-Book
Location
Online
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Adipose tissue and adipokines in health and disease

https://libcat.nshealth.ca/en/permalink/provcat33256
Giamila Fantuzzi, Theodore Mazzone, editors. (Second edition) --New York: Humana Press , c2014.
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The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous…
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Other Authors
Fantuzzi, Giamila
Mazzone, Theodore
Responsibility
Giamila Fantuzzi, Theodore Mazzone, editors
Edition
Second edition
Place of Publication
New York
Publisher
Humana Press
Date of Publication
c2014
Physical Description
1 online resource (xxvi, 372 pages)
Series
Nutrition and Health
Series Title
Nutrition and health (Totowa, N.J.)
ISBN
9781627037709 (electronic bk.)
9781627037693
Subjects (MeSH)
Adipocytes - physiology
Adipose Tissue - physiology
Obesity - complications
Obesity - etiology
Subjects (LCSH)
Adipose tissues
Fat cells
Adipocytes
Abstract
The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.
Contents
Adipose Tissue: Structure and Function -- Adipose Tissue in Evolution -- Adipose Stem Cells and Adipogenesis -- Adipose Stem Cells and Adipogenesis -- Metabolism of White Adipose Tissue -- Bad Fat or Just More Fat? Murine Models of Metabolically Healthy Obesity -- The Aging Adipose Organ: Lipid Redistribution, Inflammation, and Cellular Senescence -- Adipokines: Leptin and Adiponectin in the Regulation of Inflammatory and Immune Responses -- Adipose Tissue Inflammation and Adipocyte Dysfunction in Obesity -- Adipose Tissue Inflammation -- Endoplasmic Reticulum Stress and Adipose Tissue Function -- Autophagy in White Adipose Tissue -- Obesity and Micronutrient Deficiencies -- Obesity -- Epidemiology of Obesity in Children -- Genetics of Obesity -- Epigenetics of Obesity -- Consequences of Rapid Weight Loss -- Adipose Tissue and Disease -- Human Lipodystrophy: An Update in Molecular Genetics and Possible Mechanisms of Fat Loss -- Adipose Tissue and Type 2 Diabetes Mellitus -- Adipokines in Nonalcoholic Fatty Liver Disease -- Obesity and Cardiovascular Disease -- Respiratory Diseases in Obesity -- Adiposity and Kidney Disease -- Obesity and Joint Disease -- Obesity and Colon and Postmenopausal Breast Cancer.
Format
e-Book
Location
Online
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Adult acute lymphocytic leukemia : biology and treatment

https://libcat.nshealth.ca/en/permalink/provcat29063
--Totowa, NJ: Springer Science+Business Media , c2011.
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Online
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Other Authors
Advani, Anjali S
Lazarus, Hillard M
Place of Publication
Totowa, NJ
Publisher
Springer Science+Business Media
Date of Publication
c2011
Series Title
Contemporary hematology
ISBN
9781607617075
Subjects (MeSH)
Precursor Cell Lymphoblastic Leukemia-Lymphoma - Adult
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Subjects (LCSH)
Hematology
Oncology
Format
e-Book
Location
Online
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Advanced imaging in biology and medicine : technology, software environments, applications

https://libcat.nshealth.ca/en/permalink/provcat29967
--Berlin, Heidelberg: Springer , c2009.
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Online
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Other Authors
Sensen, Christoph W
Hallgrímsson, Benedikt
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2009
ISBN
9783540689935
Subjects (MeSH)
Diagnostic Imaging
Subjects (LCSH)
Diagnostic Imaging
Format
e-Book
Location
Online
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Advanced Imaging Techniques in Clinical Pathology

https://libcat.nshealth.ca/en/permalink/provcat39722
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors. --New York, NY: Springer New York : Imprint: Humana Press , c2016.
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This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet co…
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Sacerdoti, Francesco M
Giordano, Antonio
Cavaliere, Carlo
Responsibility
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date of Publication
c2016
Physical Description
1 online resource (ix, 165 p. : 53 illus., 37 illus. in color)
Series Title
Current clinical pathology
ISBN
9781493934690
9781493934676 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Clinical Laboratory Techniques
Diagnostic Imaging
Pathology, Clinical - methods
Abstract
This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. Advanced Imaging Techniques in Clinical Pathology will be of great value to clinical pathologists, biologists, biology researchers, and those working in the clinical and biological laboratory arena.
Contents
1 Introduction -- Part I. Basic Knowledge -- 2 Digital Image Processing -- 3 Statistical Analysis and Software -- Part II. Applications -- 4 Microscopy Techniques -- 5 Cytometry and Pathology -- 6 Advanced Imaging Techniques -- Part III. Diagnostic Imaging and Pathology -- 7 Diagnostic Imaging and Pathology -- 8 Preclinical Techniques in Animals -- 9 Preclinical Imaging: Experimental Example -- 10 Clinical Techniques in Humans -- 11 Clinical Imaging Experimental Example in Pathology -- 12 Ultrasound in the Evaluation of Cutaneous Diseases -- 13 Diagnostic Imaging Techniques: Lessons Learned -- Erratum to: Advanced Imaging Techniques in Clinical Pathology.
Format
e-Book
Location
Online
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Advanced Trauma and Surgery

https://libcat.nshealth.ca/en/permalink/provcat41958
Xiaobing Fu, Liangming Liu, editors. --Singapore: Springer , 2017.
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This book discusses different aspects of trauma surgery, ranging from the various types of trauma and their management, infection, sepsis and inflammation to tissue injury and repair in trauma. It discusses cellular, molecular and genetic research findings and their role in pathogenesis in trauma and injury. In addition, it highlights the translational application of advanced theories and technologies in the management of trauma patients. This book is a valuable resource for anyone involved in …
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Fu, Xiaobing
Liu, Liangming
Responsibility
Xiaobing Fu, Liangming Liu, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xiv, 452 pages) : 71 illus., 52 illus. in color
ISBN
9789811024252
9789811024245 (print ed.)
Subjects (MeSH)
Advanced Trauma Life Support Care
Wounds and Injuries - therapy
Traumatology
Abstract
This book discusses different aspects of trauma surgery, ranging from the various types of trauma and their management, infection, sepsis and inflammation to tissue injury and repair in trauma. It discusses cellular, molecular and genetic research findings and their role in pathogenesis in trauma and injury. In addition, it highlights the translational application of advanced theories and technologies in the management of trauma patients. This book is a valuable resource for anyone involved in the management of severe trauma damage to tissues wanting to reduce early mortality and improve patients' quality of life. Editor Xiaobing Fu is a professor and director of the Key Laboratory of Wound Repair and Regenerative Medicine of PLA, The First Affiliated Hospital of the PLA General Hospital, Beijing, China. Professor Fu is also an academician of Chinese Academy Engineering. Editor Liangming Liu is a professor at the State Key Laboratory of Trauma, Burns, and Combined Injury, Daping Hospital, Third Military Medical University, Chongqing, China.
Contents
Damage Control Theory in Treatment of Multiple Injuries -- Open Abdomen Treatment for Severe Trauma -- Advances in the Management of Thoracic Trauma -- The Normalization and Promotion of Large Craniotomy Treatment for Severe Traumatic Brain Injury -- Current Developments on Traffic Medicine -- The Features of Explosive Fragments Induced Injury and Management -- Advances in Early Treatment of Combat and Traumatic Shock -- Calcium Desensitization Mechanism and Treatment for Vascular Hyporesponsiveness After Shock -- Acute Coagulopathy of Trauma-Shock -- Research Progress in Trauma Metabolism and Nutrition -- Metabolic Changes and Nutrition Therapy in Burn Patients -- Early Prediction and Prevention of Trauma-Related Infection/Sepsis -- Genetic Polymorphisms and Trauma Precision Medicine -- Novel Inflammatory and Immunomodulatory Mediators in Sepsis -- Research Advances in Biomarker for Sepsis -- Trauma, Regulated Cell Death, and Inflammation -- To Explore Sepsis, We Need New Thought -- Regenerative Medicine in China: The Capacity, Capability and Reliability -- The Differences of Cell Biology in the Repair Process of Wound and Refractory Wound Surface -- Stem Cell Based Biotherapy for Radiation Related Injury -- Spinal Cord Injury and Regenerative Repair -- Cells Transplantation for the Repair of Peripheral Nerve Injuries -- Sweat Gland Regeneration: Basic Scientific Problems and Possible Technical Approaches.
Format
e-Book
Location
Online
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Advances and Technical Standards in Neurosurgery. Volume 43

https://libcat.nshealth.ca/en/permalink/provcat39843
Johannes Schramm, editor. (1st ed.) --Cham: Springer , c2016.
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Online
This volume reviews standard treatments for spinal dural arteriovenous fistulas, examining the anatomy of arteries and veins of the sylvian fissure, as well as microsurgical advances and the development of modern therapeutic strategies in intracranial meningiomas. The advances section presents a strategy for minimizing hearing loss after stereotactic radiosurgery for vestibular schwannomas, as well as a description of the mode of action and biology of ALA, including its interaction with tumor c…
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Schramm, Johannes
Other Authors
European Association of Neurosurgical Societies
Responsibility
Johannes Schramm, editor
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (v, 239 p. : 96 illus., 79 illus. in color)
Series Vol.
v. 43
Series Title
Advances and technical standards in neurosurgery
ISBN
9783319213590
9783319213583 (print ed.)
ISSN
0095-4829
Subjects (MeSH)
Neurosurgical Procedures
Neurosurgery - standards
Abstract
This volume reviews standard treatments for spinal dural arteriovenous fistulas, examining the anatomy of arteries and veins of the sylvian fissure, as well as microsurgical advances and the development of modern therapeutic strategies in intracranial meningiomas. The advances section presents a strategy for minimizing hearing loss after stereotactic radiosurgery for vestibular schwannomas, as well as a description of the mode of action and biology of ALA, including its interaction with tumor cells and the limits of this method. A dedicated chapter addresses the essential question of the limits (and merits) of various tractography techniques, and of their importance for non-specialists, who may be tempted to use them uncritically. A further chapter examines molecular markers, which have become standard in neuropathological reports on intracranial tumors, reviewing the prognostic and predictive value of these modern molecular markers in gliomas. Additional chapters round out the coverage, offering a comprehensive overview of standard and advanced techniques.
Contents
Spinal dural arteriovenous fistula: a review -- Intracranial Meningiomas: a 30 year experience and literature review -- Arteries and veins of the Sylvian fissure and Insula -- Hearing outcomes after stereotactic radiosurgery for vestibular schwannomas: Mechanism of hearing loss and how to preserve hearing -- Merits and Limits of various Tractography Techniques for the Un-initiated -- ALA guided surgery of high grade gliomas -- Clinical relevance of prognostic and predictive molecular markers in gliomas.
Format
e-Book
Location
Online
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Advances in Biology and Treatment of Glioblastoma

https://libcat.nshealth.ca/en/permalink/provcat41809
Kumaravel Somasundaram, editor. --Cham: Springer , 2017.
Available Online
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Location
Online
This volume covers the most important areas of glioblastoma: surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.
Available Online
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Other Authors
Somasundaram, Kumaravel
Responsibility
Kumaravel Somasundaram, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (ix, 272 pages) : 24 illus. in color
Series Title
Current cancer research
ISBN
9783319568201
9783319568195 (print ed.)
ISSN
2199-2584
Subjects (MeSH)
Glioblastoma - pathology
Neurosurgical Procedures - methods
Abstract
This volume covers the most important areas of glioblastoma: surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.
Contents
1. Maximal Safe Resection in Glioblastoma: Use of Adjuncts -- 2. Molecular Pathology of Glioblastoma- an Update -- 3. Current Therapies and Future Directions in Treatment of Glioblastoma -- 4. Recent Advances for Targeted Therapies in Glioblastoma -- 5. Targeting EGFR in Glioblastoma: Molecular Biology and Current Understanding -- 6. Radiogenomics & Histomics in Glioblastoma: The Promise of Linking Image-derived Phenotype with Genomic Information -- 7. Next-generation Sequencing in Glioblastoma Personalized Therapy -- 8. Glioma Stem-like Cells in Tumor Growth and Therapy Resistance of Glioblastoma -- 9. Animal Models in Glioblastoma: Use in Biology and Developing Therapeutic Strategies -- 10. Pediatric High Grade Glioma.
Format
e-Book
Location
Online
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Advances in cancer biology - metastasis

https://libcat.nshealth.ca/en/permalink/provcat51380
Elsevier B.V.
Available Online
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Holdings
v. 1, 2021 -
Location
Online
Available Online
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Publisher
Elsevier B.V.
Holdings
v. 1, 2021 -
ISSN
2667-3940
Format
e-Journal
Location
Online
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Advances in diagnostic imaging : the value of contrast-enhanced ultrasound for liver

https://libcat.nshealth.ca/en/permalink/provcat29300
by Riccardo Lencioni, Clotilde Pina, Laura Crocetti, Dania Cioni, Hans Peter Weskott, Jean-Michel Correas, Ahmed Khairoune, Anais Vallet-Pichard, Stanislas Pol, Olivier Hélénon ; edited by Luigi Bolondi. --Milan: Springer-Verlag Italia , c2006.
Available Online
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Location
Online
Available Online
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Author
Bolondi, Luigi
Other Authors
Lencioni, Riccardo
Pina, Clotilde
Crocetti, Laura
Cioni, Dania
Weskott, Hans Peter
Correas, Jean-Michel
Khairoune, Ahmed
Vallet-Pichard, Anais
Pol, Stanislas
Hélénon, Olivier
Responsibility
by Riccardo Lencioni, Clotilde Pina, Laura Crocetti, Dania Cioni, Hans Peter Weskott, Jean-Michel Correas, Ahmed Khairoune, Anais Vallet-Pichard, Stanislas Pol, Olivier Hélénon ; edited by Luigi Bolondi
Place of Publication
Milan
Publisher
Springer-Verlag Italia
Date of Publication
c2006
ISBN
9788847004580
Subjects (MeSH)
Contrast Media
Liver - diagnostic imaging
Liver Diseases - diagnostic imaging
Ultrasonography
Subjects (LCSH)
Diagnosis, Ultrasonic
Gastroenterology
Hepatology
Contents
1. Impact of European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Guidelines on the Use of Contrast Agents in Liver Ultrasound -- 2. The Role of Contrast-Enhanced Ultrasound (CEUS) in Identifying and Characterizing Focal Liver Lesions -- 3. Contrast-Enhanced Ultrasound in the Management of Cirrhotic Patients: HCCDiagnosis, Staging and Monitoring of Percutaneous Treatments.
Format
e-Book
Location
Online
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Advances in Geroscience

https://libcat.nshealth.ca/en/permalink/provcat39908
Felipe Sierra, Ronald Kohanski, editors. (1st ed.) --Cham: Springer , c2016.
Available Online
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Location
Online
This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a…
Available Online
View e-Book
Other Authors
Sierra, Felipe
Kohanski, Ronald
Responsibility
Felipe Sierra, Ronald Kohanski, editors
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xxiii, 622 p. : 39 illus.)
ISBN
9783319232461
9783319232454 (print ed.)
Subjects (MeSH)
Aging - physiology
Chronic Disease
Geriatrics
Risk Factors
Abstract
This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or "healthspan". The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer's diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Contents
The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging? / Steven N. Austad -- Etiological Role of Aging in Chronic Diseases: From Epidemiological Evidence to the New Geroscience / Linda P. Fried and Luigi Ferrucci -- The Impact of Aging on Cancer Progression and Treatment / Shenghui He and Norman E. Sharpless -- The Impact of Cancer Treatments on Aging / Changhan Lee and Valter Longo -- Cardiovascular Disease and Aging / Ying Ann Chiao, Edward Lakatta, Zoltan Ungvari, Dao-Fu Dai and Peter Rabinovitch -- The Impact of Aging on Ischemic Stroke / Farida Sohrabji -- Parkinson's Disease and Aging / Julie K. Andersen -- The Role of Aging in Alzheimer's Disease / Geoffrey A. Kerchner and Tony Wyss-Coray -- Aging and the Bone-Muscle Interface / Simon Melov and Clifford J. Rosen -- Osteoporosis and Mechanisms of Skeletal Aging / Julie Glowacki and Tamara Vokes -- Osteoarthritis in the Elderly / Richard F. Loeser and Martin Lotz -- Diabetes and Aging / Nicolas Musi and Andrzej Bartke -- Renal Aging and Transplantation / John P. Higgins and Stuart K. Kim -- Asthma and Aging / Nicola A. Hanania and Paula Busse -- Aging in COPD and Idiopathic Pulmonary Fibrosis / Cecilia Sanchez -- Age-Related Macular Degeneration and Vision Impairment / Jayakrishna Ambati and Charles Wright -- HIV and Aging: Parallels and Synergistic Mechanisms Leading to Premature Disease and Functional Decline / Anna Hearps, Katherine Schafer, Kevin High and Alan Landay -- Pain in the Elderly / Roger B. Fillingim, Dennis C. Turk and Robert P. Yezierski -- The Way Forward / translation: James L. Kirkland.
Format
e-Book
Location
Online
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Advances in molecular toxicology. Vol. 1

https://libcat.nshealth.ca/en/permalink/provcat27194
edited by James C. Fishbein. --Amsterdam, Netherlands: Elsevier , 2006.
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Location
Online
Available Online
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Author
Fishbein, James C
Responsibility
edited by James C. Fishbein.
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier
Date of Publication
2006
ISBN
9786610707997
Subjects (MeSH)
Toxicology
Molecular Biology
Contents
Cover -- Contents -- Contributors -- Editor's Preface -- Bioactivation of Estrogens to Toxic Quinones -- Introduction -- Mechanisms of Estrogen Carcinogenesis -- Oxidation of Catechol Estrogens to O-Quinones -- DNA Damage Induced by Catechol Estrogens -- Protein Damage Induced by Catechol Estrogens -- Role of the Estrogen Receptor in Estrogen Carcinogenesis -- Substitution of the 4-Hydroxy group on Catechol Estrogens with Fluorine Abolishes Quinoid Formation while Maintaining Estrogenic Activity -- Summary -- Acknowledgment -- References -- Diverse Mechanisms of Endogenous Nucleobase Deamination in DNA and RNA -- Introduction -- Simple Hydrolytic Mechanisms -- Nitrosative Deamination and Inflammation -- Enzymatic Deamination of Nucleobases -- Purine Metabolism as a Source of Nucleobase Deamination in DNA and RNA -- Repair and Mutagenesis of Nucleobase Deamination Products -- Summary -- Acknowledgments -- References -- Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression -- Introduction -- Patterns of Keap1 Modification by Electrophiles -- Relationship of Keap1 Modification Sites and Functionally Significant Cysteine Residues -- Electrophile-Induced Ubiquitination of Keap1 -- Unresolved Questions about Electrophile-Induced Activation of NRF2 -- Acknowledgments -- References -- Genotoxicity of Chlorophenols and Ochratoxin A -- Introduction -- Chlorophenols -- Ochratoxin A -- Acknowledgments -- References -- Idiosyncratic Drug Reactions: Clinical Evidence for Mechanistic Hypotheses -- Background -- Postulated Mechanisms -- Summary and Conclusions -- Acknowledgments -- References -- Subject Index -- Last Page
Format
e-Book
Location
Online
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Advances in Radiation Oncology

https://libcat.nshealth.ca/en/permalink/provcat41714
Jeffrey Y.C. Wong, Timothy E. Schultheiss, Eric H. Radany. --Cham: Springer , 2017.
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Location
Online
This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the phys…
Available Online
View e-Book
Other Authors
Wong, Jeffrey Y.C.
Schultheiss, Timothy E.
Radany, Eric H.
Responsibility
Jeffrey Y.C. Wong, Timothy E. Schultheiss, Eric H. Radany
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (viii, 271 pages) : 48 illus., 40 illus. in color
Series Vol.
172
Series Title
Cancer treatment and research
ISBN
9783319532356
9783319532332 (print ed.)
ISSN
0927-3042
Subjects (MeSH)
Neoplasms - radiotherapy
Radiation Oncology - methods
Radioimmunotherapy - methods
Radiotherapy, Image-Guided - methods
Abstract
This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.
Contents
Use of Multi-parametric MRI in Radiotherapy -- MRI Guided Radiotherapy -- MRI Guided Focused Ultrasound and Thermal Oncology -- Use of PET and Novel Molecular Imaging in IGRT -- The Impact of IGRT on Normal Tissue Toxicity -- Image Guided Brachytherapy -- Hypofractionated IGRT for the treatment of primary cancers -- SBRT and the treatment of oligometastatic disease -- Molecular and image guided systemic targeted radiotherapy -- Integrating Radiotherapy and Immunotherapy -- Biomarkers and Radiotherapy -- Application of Mathematical and Systems Biology to Radiotherapy -- The Importance of Cancer Stem Cells in Radiotherapy -- Targeting DNA repair mechanisms in radiotherapy.
Format
e-Book
Location
Online
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Advances in tumor immunology and immunotherapy

https://libcat.nshealth.ca/en/permalink/provcat33290
Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa, editors. --New York: Springer , c2014.
Available Online
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Location
Online
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon res…
Available Online
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Other Authors
Rosenblatt, Joseph D
Responsibility
Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa, editors
Place of Publication
New York
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (ix, 371 pages)
Series Title
Current cancer research
ISBN
9781461488095 (electronic bk.)
9781461488088
Subjects (MeSH)
Antigens, Neoplasm - immunology
Neoplasms - immunology
Neoplasms - therapy
T-Lymphocytes, Cytotoxic - immunology
Immunotherapy - methods
Subjects (LCSH)
Tumors - Immunological aspects
Cancer - Immunological aspects
Antigens, Neoplasm - immunology
Neoplasms - therapy
T-Lymphocytes, Cytotoxic - immunology
Cancer - Immunotherapy
Neoplasms - Immunology
Abstract
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
Contents
Part I. Immune Activation, Suppression and Manipulation of the Immune Antitumor Response -- Myeloid-Derived Suppressor Cells in Cancer -- The Role of B Cells in Shaping the Antitumor Immune Response -- Heat-Shock Protein-Based Cancer Immunotherapy -- Activation of NK Cell Responses and Immunotherapy of Cancer -- Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay -- Employing T Cell Homeostasis as an Antitumor Strategy -- Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor -- Part II. Evolving Clinical Immunotherapeutic Strategies -- Immunotherapy in Renal Cell Carcinoma -- Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies -- Bifunctional Antibodies: Preclinical and Clinical Applications -- Clinical Development of Antibody-Fusion Proteins for Cancer Therapy -- Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy -- The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities -- T Cell Co-regulatory Signals and Their Role in Cancer Therapy -- Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints.
Format
e-Book
Location
Online
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