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Alkaloids : chemistry, biology, ecology and applications

https://libcat.nshealth.ca/en/permalink/provcat34094
by Dr. Tadeusz Aniszewski. (2nd ed.) --Amsterdam, Netherlands: Elsevier , c2015.
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Alkaloids: chemistry, biology, ecology and applications provides knowledge on structural typology, biosynthesis and metabolism in relation to recent research work on alkaloids, considering an organic chemistry approach to alkaloids using biological and ecological explanation. The book approaches several questions and unresearched areas that persist in this field of research. It provides a beneficial text for academics, professionals or anyone who is interested in the fascinating subject of alk…
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Author
Aniszewski, Tadeusz
Responsibility
by Dr. Tadeusz Aniszewski
Edition
2nd ed.
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier
Date of Publication
c2015
Physical Description
1 online resource, 496 p.
ISBN
9780444594624
Subjects (MeSH)
Alkaloids
Subjects (LCSH)
Alkaloids
Abstract
Alkaloids: chemistry, biology, ecology and applications provides knowledge on structural typology, biosynthesis and metabolism in relation to recent research work on alkaloids, considering an organic chemistry approach to alkaloids using biological and ecological explanation. The book approaches several questions and unresearched areas that persist in this field of research. It provides a beneficial text for academics, professionals or anyone who is interested in the fascinating subject of alkaloids.
Format
e-Book
Location
Online
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Creatine and Creatine Kinase in Health and Disease

https://libcat.nshealth.ca/en/permalink/provcat40574
edited by Gajja S. Salomons and Markus Wyss. --Dordrecht: Springer , c2007.
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Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate inter…
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Other Authors
Salomons, Gajja S
Wyss, Markus
Responsibility
edited by Gajja S. Salomons and Markus Wyss
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2007
Physical Description
1 online resource (xvii, 351 p.)
Series Vol.
v. 46
Series Title
Subcellular Biochemistry
ISBN
9781402064869
9781402064852 (print ed.)
ISSN
0306-0225
Subjects (MeSH)
Creatine Kinase
Creatine
Abstract
Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function, neurodegenerative disease and/or neuroprotection on the other hand. The book also elaborates on the recently identified inborn errors of creatine biosynthesis and transport, the so-called cerebral creatine deficiency syndromes. The clinical hallmarks of these disorders are mental retardation, epilepsy, autistic-like behaviour, and speech and language delay. In addition, the muscle growth- and strength-promoting effects, the pharmacokinetics and the safety of oral creatine supplementation are discussed. Finally, the present book outlines the emerging "systems biology" approaches for understanding the pleiotropic effects of creatine and creatine kinase, and hypothesizes on the most promising and influential future avenues of research towards creatine-based nutritional strategies for the prevention of neurological disease, and for improving the quality of life in general.
Contents
Introduction. Creatine: Cheap Ergogenic Supplement with Great Potential for Health and Disease -- Early Evolution of the Creatine Kinase Gene Family and the Capacity for Creatine Biosynthesis and Membrane Transport -- The Creatine Kinase Phosphotransfer Network: Thermodynamic and Kinetic Considerations, the Impact of the Mitochondrial Outer Membrane and Modelling Approaches -- Expression and Function of Agat, Gamt and CT1 in the Mammalian Brain -- A Novel Relationship Between Creatine Transport at the Blood-Brain and Blood-Retinal Barriers, Creatine Biosynthesis, And its Use for Brain and Retinal Energy Homeostasis -- Functional Insights into the Creatine Transporter -- In Vivo Magnetic Resonance Spectroscopy of Transgenic Mice with Altered Expression of Guanidinoacetate Methyltransferase and Creatine Kinase Isoenzymes -- Cerebral Creatine Deficiency Syndromes: Clinical Aspects, Treatment and Pathophysiology -- Pre-Symptomatic Treatment of Creatine Biosynthesis Defects -- Clinical Use of Creatine in Neuromuscular and Neurometabolic Disorders -- The Neuroprotective Role of Creatine -- Ergogenic Effects of Creatine in Sports and Rehabilitation -- Pharmacokinetics of Creatine -- Safety of Creatine Supplementation -- Creatine: its Chemical Synthesis, Chemistry, and Legal Status -- Creatine and Creatine Kinase in Health and Disease: A Bright Future Ahead?
Format
e-Book
Location
Online
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Gene therapy of cancer

https://libcat.nshealth.ca/en/permalink/provcat50735
Lattime, Edmund. (3rd ed.) --Philadelphia, PA: Elsevier , 2014.
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Location
Online
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Author
Lattime, Edmund
Edition
3rd ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
2014
ISBN
9780123942951
Subjects (MeSH)
Neoplasms - genetics
Neoplasms - therapy
Genetic Therapy - methods
Immunotherapy - methods
Protein Biosynthesis - genetics
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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Human Fetal Growth and Development : First and Second Trimesters

https://libcat.nshealth.ca/en/permalink/provcat39764
Niranjan Bhattacharya, Phillip G. Stubblefield, editors. --Cham: Springer , c2016.
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This book addresses the complexities of growth and maturation, structural and functional developments as well as differentiations of the human fetus. Many of the authors are part of the Institute of Post-Graduate Medical Education and Research (IPGMER), whose research into human foetuses has generated many studies on the fetus, ranging from the morphometry and growth of organs, the DNA and RNA to different proteins and enzymes. The data collected over many decades provides a deep insight into t…
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Other Authors
Bhattacharya, Niranjan
Stubblefield, Phillip G
Responsibility
Niranjan Bhattacharya, Phillip G. Stubblefield, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xxxv, 593 p. : 162 illus., 122 illus. in color)
ISBN
9783319148748
9783319148731 (print ed.)
Subjects (MeSH)
Embryonic Development
Fetal Development
Pregnancy Trimester, First
Pregnancy Trimester, Second
Abstract
This book addresses the complexities of growth and maturation, structural and functional developments as well as differentiations of the human fetus. Many of the authors are part of the Institute of Post-Graduate Medical Education and Research (IPGMER), whose research into human foetuses has generated many studies on the fetus, ranging from the morphometry and growth of organs, the DNA and RNA to different proteins and enzymes. The data collected over many decades provides a deep insight into the growth and development of the human fetus, its aberrations and implications for understanding the intricacies and complexities of growth regulation up to twenty weeks of gestation. The editors bring together this extensive research from IPGMER, in addition to astute and precision research from global leaders in the fields of genetics, proteomics stem cell biology, endocrinology and molecular biology. Human Fetal Growth and Development: First and Second Trimesters is a pioneering work, stimulating further allied research in this area, and will be of interest to gynecologists, pediatricians, obstetricians, neonatologists, endocrinologists, reproductive and molecular biologists, and all students of medicine at all levels.
Contents
Part 1. Introduction -- 1. What is Fetal Growth -- 2. Vaccination of the Unborn: A Perspective -- 3. Understanding the Growth of the Fetus in Utero from the Immunologist's Angle -- 4. Intraamniotic Antigen and Disruption of Human Fetal Growth: A Study from 1978-2002 with Subsequent Follow Up -- 5. Foetal Growth and Development in the First Two Trimesters -- Part 2. Structural and Functional Fetal Development up to Second Trimester -- 6. Anthropometric Measurement of the Human Fetus -- 7. Human Fetal Carbohydrate Metabolism -- 8. Mucopolysaccharides, Water and Electrolytes of Human Fetal Organs -- 9. Urea Biosynthesis in Human Fetal Liver -- 10. Mechanism of Rejection of Human Fetal Adrenal Cortex -- 11. Development of Human Fetal Brain -- 12. Lipid Metabolism in the Human Fetus Development -- Part 3. Gene and Human Fetal Development up to Second Trimester -- 13. Gene Regulatory Networks and Epigenetic Modifications in Cell Fate Decisions During the Early Embryonic Development -- 14. Personal Human Life Begins with the Formation of Adult Type Hippocampus at 13th Week of Development -- 15. Dependence of Fetal Hairs and Sebaceous Glands on Fetal Adrenal Cortex and Possible Control from Epidermal Merkel Cells and Adrenal Medulla -- 16. Theoretical Postulation of the Embryological Basis of the Virgin Birth and Role of Embryonic Stem Cells Localized out of the Embryo -- 17. Aneuploidy in Human Preimplantation Embryos -- 18. The Potential Impact of Maternal Milk Consumption during Pregnancy on mTORC1-Driven Fetal Growth -- 19. Genetic Disease Specific Human Embryonic Stem Cell Lines -- Part 4. Impact of Stem Cell on Growth and Development of Human Fetus -- 20. Stem Cells in Growth and Development of the Human Fetus -- 21. The Mystery of the Survival of the Human Fetus in Utero -- Part 5. Fetal Endocrine Development up to Second Trimester -- 22. Glucose Metabolism in Foetus and Its Relationship with Foetal Insulin -- 23. Growth and Maturation of the Human Fetal Endocrine System Up to Twenty Four Weeks of Gestation -- Partá6. Fetal Immune Development: Up To Second Trimester.-á24. Development of Human Immune System in First and Second Trimester -- Part 7. Fetal Hepatic Development: Up To Second Semester -- 25. Growth and Development of Human Liver and Its Future Implications -- 26. Embryonic Development of Liver and its Future Implications -- Part 8. Fetal Cardiovascular Development: Up To Second Semester -- 27. Embryological Basis for Vascular Anomalies -- 28. Cardio Vascular Developmental Abnormality of the Human Fetus Appearing within Second Trimester: Detection and Treatment -- Part 9. Fetal Neurological Development: Up To Second Trimester and Its Implication in Adult Neurodegenerative Disease -- 29. Implications of Fetal Development and Neurodegeneration in Adult Life -- Part 10. Fetal Neuropsychiatric Development: Up To Second Trimester -- 30. Very Low Birth Weight Babies and Their Mental Health Outcome -- Part 11. Fetal Nephrological Development: Up To Second Trimester -- 31. Development of Renal Tissues in First Twenty Weeks -- Part 12. Fetal Haematological Development -- 32. Development of Heamopoiesis System Before Second Trimester of Pregnancy -- Part 13. Pharmacological Implication of Fetal Development: Up To Second Trimester -- 33. Liabilities of Fetus: As a Patient -- 34. Fetus as a Patient During the First and Second Trimester of Growth and Development -- 35. Structural and Functional Developmental Perspectives of the Placental Barrier and its Role in the Fetal Development During the 1st and 2nd Trimester -- Part 14. Surgical Implications of Fetal Development: Up To Second Trimester -- 36. Surgery of the Unborn/Fetal Surgery -- 37. Reflections on Reality: Towards Scarless Healing- D©j©á Vu -- Part 15. Fetal Growth and Adult Life Implications -- 38. Implications of Gross IUGR in Adult Life with Respect to Some Major Diseases -- Part 16. Understanding Fetal Growth from the Perspective of Alternative Medicine -- 39. Growth and Development of the Human Fetus Up to 2nd Trimester: A Perspective of Traditional Chinese Medicine -- 40. Perspectives of Tribal Medicine During the First 6 Months of Pregnancy -- 41. General Perspectives and Applications of Unani Medicine in Pregnancy up to 2nd Trimester -- 42. Applications of Traditional Chinese Medicine Concpts in the Safety and Development of the Fetus During The 1st and 2nd Trimesters of Pregnancy -- 43. General Perspectives of Homeopathic Medicine During the First and Second Trimester of Pregnancy -- 44. Ayurvedic Perspective of the Pregnancy and Fetal Development During the First and Second Trimesters -- Part 17. Miscellaneous.-á45. Problems of Prematurity -- 46. Problms of Extreme Prematurity -- 47. Sequencing of Naturally Aborted Human Fetuses: A Resource for New Knowledge -- Part 18. Ethics and Human Fetal Tissue Research -- 48. Ethics Pertaining to the Use of Aborted Human Tissues for Research and Therapeutic Purposes.
Format
e-Book
Location
Online
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Inherited Metabolic Diseases : A Clinical Approach

https://libcat.nshealth.ca/en/permalink/provcat41877
Georg F. Hoffmann, Johannes Zschocke, William L. Nyhan, editors. (Second edition) --Berlin, Heidelberg: Springer , 2017.
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This book focuses on clinical presentations that may be caused by inherited metabolic diseases. Its symptom- and system-based approach will help clinicians with and without detailed knowledge of human biochemistry in all specialties to reach a correct diagnosis and institute the optimal treatment program. The book summarizes the central elements of inherited metabolic diseases and describes clearly how to carry out an efficient yet complete diagnostic work-up, thereby guiding the clinician from…
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Other Authors
Hoffmann, Georg F. (Georg Friedrich)
Zschocke, Johannes
Nyhan, William L.
Responsibility
Georg F. Hoffmann, Johannes Zschocke, William L. Nyhan, editors
Edition
Second edition
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xvii, 605 pages) : 80 illus., 34 illus. in color
ISBN
9783662494103
9783662494080 (print ed.)
Subjects (MeSH)
Metabolism, Inborn Errors - diagnosis
Metabolism, Inborn Errors - genetics
Metabolism, Inborn Errors - therapy
Abstract
This book focuses on clinical presentations that may be caused by inherited metabolic diseases. Its symptom- and system-based approach will help clinicians with and without detailed knowledge of human biochemistry in all specialties to reach a correct diagnosis and institute the optimal treatment program. The book summarizes the central elements of inherited metabolic diseases and describes clearly how to carry out an efficient yet complete diagnostic work-up, thereby guiding the clinician from the presenting symptoms and signs through to effective initial management. After an introduction to the different disorders, the book explains when to consider an inborn metabolic error and which initial tests to order. Core aspects such as structured communication, guidelines, transition, pregnancy, maternal care and how to respond to various medical emergencies are covered. Therapeutic concepts such as dietary treatment are delineated and practical advice provided on the quite different treatment approaches required for individual diseases. An extensive section structured according to organ systems outlines the correct approach in the context of specific symptoms and signs. The value of each of the potential investigations is explained, with precise advice on the interpretation of results. The inclusion of algorithms, tables, lists, and charts facilitates rapid decision making and information retrieval, and the appendices include a helpful guide to differential diagnosis based on clinical and biochemical phenotypes. This new updated edition of Inherited Metabolic Diseases will be an invaluable aid for the busy clinician and an excellent quick reference for metabolic and genetic specialists.
Contents
Part I: Introduction to Inborn Errors of Metabolism -- 1. Disorders of Intermediary Metabolism -- 2. Disorders of the Biosynthesis and Breakdown of Complex Molecules -- 3. Neurotransmitter Defects and Related Disorders -- Part II: Approach to the Patient -- 4. When to Suspect Metabolic Disease -- 5. Patient Care and Treatment -- 6. Inherited Metabolic Diseases in the Context of Rare/Orphan Diseases -- 7. Structured Communication and Behavioural Medicine -- 8. Guidelines and Follow-Up -- 9. Patient and Family Associations -- 10. Adolescence, Emerging Adulthood, and Problems of Transition -- 11. Pregnancy and Maternal Care -- 12. Metabolic Emergencies -- 13. Workup of the Patient with Metabolic Acidosis and Massive Ketosis -- 14. Workup of the Patient with Lactic Acidemia: Mitochondrial Disease -- 15. Work-Up of the Patient with Hypoglycemia -- 16. Approach to the Child Suspected of Having a Disorder of Fatty Acid Oxidation -- 17. Work-Up of the Patient with Hyperammonemia -- 18. Work-Up of the Patient with Acute Neurological or Psychiatric Manifestations -- 19. Emergency Treatment of Inherited Metabolic Diseases -- 20. Anesthesia and Metabolic Disease -- 21. Principles of Dietary Management -- 22. Gene and Cell Therapy for Inborn Errors of Metabolism -- Part III: Organ Systems in Metabolic Disease -- 23. Approach to the Patient with Cardiovascular Disease -- 24. Liver Disease -- 25. Gastrointestinal and General Abdominal Symptoms -- 26. Kidney Disease and Electrolyte Disturbances -- 27. Neurological Disease -- 28. Metabolic Myopathies -- 29. Psychiatric Disease -- 30. Eye Disorders -- 31. Skin and Hair Disorders -- 32. The Bone in Genetic and Metabolic Diseases: A Practical Approach -- 33. Physical Abnormalities in Metabolic Diseases -- 34. Hematological Disorders -- 35. Immunological Problems -- Part IV: Investigations for Metabolic Diseases -- 36. Newborn Screening for Inherited Metabolic Disease -- 37. Biochemical Studies -- 38. Enzyme Diagnostics in a Changing World of Exome Sequencing and Newborn Screening as Exemplified for Peroxisomal, Mitochondrial, and Lysosomal Disorders -- 39. Molecular Genetic Analyses -- 40. Family Issues, Carrier Tests and Prenatal Diagnosis -- 41. Function Tests -- 42. Diagnostic Workup of Patients with Mitochondrial Diseases -- 43. Pathology: Biopsy -- 44. Postmortem Investigations -- 45. Neuroradiology.
Format
e-Book
Location
Online
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Pediatric Gynecology : An Illustrated Guide for Surgeons

https://libcat.nshealth.ca/en/permalink/provcat45663
Ahmed H. Al-Salem. --Cham: Springer , c2020.
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Online
This richly-illustrated book is a reader-friendly reference guide on pediatric gynecology covering both congenital and acquired conditions. Discussing a broad range of conditions from ovarian cysts and endometriosis to disorders of sexual development and breast disorders, this book presents the topics in a concise manner using a practical approach. Each chapter is divided into sections that cover all aspects of the topic including radiology, surgery and clinical aspects and the text is accompan…
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Author
Al-Salem, Ahmed H.
Responsibility
Ahmed H. Al-Salem
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xvii, 478 p.) : 372 illus., 342 illus. in color
ISBN
9783030499846
9783030499839 (Print ed.)
9783030499853 (Print ed.)
9783030499860 (Print ed.)
Subjects (MeSH)
Child
Disorders of Sex Development
Female Urogenital Diseases
Specialty
Gynecology
Pediatrics
Abstract
This richly-illustrated book is a reader-friendly reference guide on pediatric gynecology covering both congenital and acquired conditions. Discussing a broad range of conditions from ovarian cysts and endometriosis to disorders of sexual development and breast disorders, this book presents the topics in a concise manner using a practical approach. Each chapter is divided into sections that cover all aspects of the topic including radiology, surgery and clinical aspects and the text is accompanied by ample images.The book will be of use to general surgeons, pediatricians, pediatric surgeons, pediatric endocrinologists, pediatric urologists, obstetricians and gynaecologists.
Contents
1. Development of the Female Reproductive System -- 2. Delayed Puberty in Girls -- 3. Precocious Puberty -- 4. Breast Disorders in Female Children and Adolescents -- 5. Fused Labia (Labial Adhesions) -- 6. Imperforate Hymen -- 7. Labial and Inter-Labial Masses -- 8. Pediatric Vulvovaginal Disorders and Vulvovaginitis -- 9. Inguinal and Femoral Hernias in Girls -- 10. Persistent Mullerian Duct Syndrome -- 11. Vaginal Atresia, Agenesis and Vaginal Septum -- 12. Cloacal Anomalies -- 13. Menstruation Disorders in Adolescents -- 14. Polycystic Ovarian Syndrome -- 15. Endometriosis in Adolescent Girls -- 16. Amenorrhea in Adolescents -- 17. Ovarian Cysts and Tumors -- 18. Rhabdomyosarcoma of Female Children Genital Tract -- 19. Disorders of Sexual Development -- 20. Congenital Adrenal Hyperplasia (CAH) -- 21. Androgen Insensitivity Syndrome (Testicular Feminization Syndrome) -- 22. Deficient Testosterone Biosynthesis -- 23. Gonadal Dysgenesis -- 24. Ovotestis Disorders of Sexual Development.
Format
e-Book
Location
Online
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Vancomycin : biosynthesis, clinical uses and adverse effects

https://libcat.nshealth.ca/en/permalink/provcat32708
edited by Abu Gafar Hossion. --New York, NY: Nova Biomedical , c2013.
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Online
There have been news reports with the tales of many community acquired bacterial infections that lead to serious hospitalization. The last resort drug for these infections is vancomycin; an FDA approved glycopeptide antibiotic for the treatment of several bacterial infections, including infections caused by susceptible staphylococcus, streptococcus, enterococcus, and diphtheroid organisms. Around the world in 1997, initial reports of reduced vancomycin susceptibility in clinical isolates of sta…
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Other Authors
Hossion, Abu Gafar
Responsibility
edited by Abu Gafar Hossion
Place of Publication
New York, NY
Publisher
Nova Biomedical
Date of Publication
c2013
Physical Description
162 p.
Series Title
Pharmacology - research, safety testing and regulation
ISBN
9781629485706
Subjects (MeSH)
Infection control
Vancomycin Resistance
Abstract
There have been news reports with the tales of many community acquired bacterial infections that lead to serious hospitalization. The last resort drug for these infections is vancomycin; an FDA approved glycopeptide antibiotic for the treatment of several bacterial infections, including infections caused by susceptible staphylococcus, streptococcus, enterococcus, and diphtheroid organisms. Around the world in 1997, initial reports of reduced vancomycin susceptibility in clinical isolates of staphylococcus aureus generated significant concern in the medical community. There has been uncertainty regarding optimal laboratory tests and the clinical relevance of reduced vancomycin susceptibility in S. aureus; changes in the Clinical and Laboratory Standards Institute (CLSI) breakpoints for vancomycin against S. aureus; and increasing concern regarding the efficacy of vancomycin for the treatment of infection due to gram-positive bacteria, such as S. aureous. Vancomycin can be administered either intravenously or orally, but in order to treat systemic infections, vancomycin must be administered intravenously. Identifying the changes in genome content or expression, which are associated with the acquisition of the different types of vancomycin resistance, is an important step in the process of understanding the molecular basis of resistance with the potential to provide leads both for new drug targets and diagnostic biomarkers. However, considering that vancomycin has a slow bactericidal activity, clinicians have to adequately prescribe vancomycin to avoid the acquisition of resistance under therapy and to facilitate the cure.
Format
e-Book
Location
Online
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Why love matters : how affection shapes a baby's brain

https://libcat.nshealth.ca/en/permalink/provcat54641
Gerhardt, Sue. --Hove ; New York: Brunner-Rutledge , 2004.
Call Number
WS 105.5 F2 G368w 2004
Location
IWK Health Sciences Library
Call Number
WS 105.5 F2 G368w 2004
Author
Gerhardt, Sue
Place of Publication
Hove ; New York
Publisher
Brunner-Rutledge
Date of Publication
2004
Physical Description
246 p. : ill.
ISBN
1583918175
Subjects (MeSH)
Brain - growth & development
Brain Chemistry
Emotions - physiology
Hydrocortisone - biosynthesis
Mental Disorders - chemically induced
Mental Disorders - prevention & control
Personality Development
Infant
Format
Book
Location
IWK Health Sciences Library
Copies
1
Loan Period
2 weeks
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