Natural products and cancer drug discovery
https://libcat.nshealth.ca/en/permalink/provcat32397
Frank E. Koehn, editor.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery. The historical record is strong, but what is the current impact of natural products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of future agents? This volume attempts to address this question through a series of chapters authored by leading res…
- Available Online
- View e-Book
- Other Authors
- Koehn, Frank E
- Responsibility
- Frank E. Koehn, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xii, 244 p. : 94 ill., 17 ill. in color)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781461446545
- Subjects (MeSH)
- Antineoplastic Agents
- Biological Agents - pharmacology
- Drug Discovery
- Neoplasms - drug therapy
- Subjects (LCSH)
- Oncology
- Toxicology
- Abstract
- Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery. The historical record is strong, but what is the current impact of natural products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of future agents? This volume attempts to address this question through a series of chapters authored by leading researchers in the field which effectively provide an in-depth view of several high impact areas of natural products cancer research. The volume begins with a focused analysis and rationale for the clinical success of current natural product anti-cancer drugs. The following chapters then describe new natural product based drugs in three rapidly evolving target classes and modalities- agents which target tumor vasculature, inhibitors of histone deacetylase and other histone modifying enzymes, and antibody drug conjugates. Subsequent chapters examine the central role of natural product chemical scaffolds in the genesis of new anti-cancer therapeutics- first via the powerful application of chemical synthesis, and then through the rapidly emerging fields of biosynthetic engineering and plant cell culture. The volume concludes with an assessment of the critical role that natural products continue to play in the search for new cancer drug targets. As the reader makes his or her way through the volume it may become clear that there is strong evidence that natural products will continue to exert a profound positive impact on cancer drug discovery.
- Contents
- Preface.-The Impact of Natural Products upon Cancer Chemotherapy -- Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth -- Discodermolide: Past, Present and Future -- HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents -- Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates -- Natural Product Scaffolds in Cancer Therapy -- The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery -- Accessing Anti-Cancer Natural Products by Plant Cell Culture -- Natural Products as Tools for Discovering New Cancer Targets -- Index.
- Format
- e-Book
- Location
- Online
Preterm labour : managing risk in clinical practice
https://libcat.nshealth.ca/en/permalink/provcat27223
edited by Jane Norman, Ian Greer.
--Cambridge, UK:
Cambridge University Press
, 2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Norman, Jane E
- Other Authors
- Greer, I. A
- Responsibility
- edited by Jane Norman, Ian Greer
- Alternate Title
- Preterm labor
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- 2005
- Physical Description
- x, 417 p.
- ISBN
- 6610217963 (electronic bk.)
- Subjects (MeSH)
- Obstetric Labor, Premature
- Premature Birth
- Infant, Premature
- Contents
- Cover -- Half-title -- Title -- Copyright -- Table of Contents -- Contributors -- Preface -- 1 The epidemiology of preterm labour and delivery -- Defining the problem -- Definition of preterm delivery -- Determination of gestational age -- Incidence and secular trends -- Causes of preterm delivery -- Iatrogenic -- Idiopathic -- Infection -- Risk factors for preterm labour -- Maternal risk factors -- Summary -- References -- 2 Biology of preterm labour -- Introduction -- Myometrial contractions -- Organisation of myometrial smooth muscle -- Electrical activity -- Calcium and uterine contractions -- Control of myometrial function -- Cervical ripening -- Structure of the cervix -- The cervix during pregnancy -- Cervical ripening -- The control of cervical ripening -- Biology of membrane rupture -- Structure of fetal membranes -- Morphological changes associated with membrane rupture at term -- Biochemical events associated with membrane rupture at term -- Preterm premature rupture of the membranes (pPROM) -- Summary -- Biology of labour at term -- Role of infection -- Summary -- References -- 3 Transcriptional regulation of labour-associated genes -- Introduction -- Enzymes of the prostaglandin biosynthetic pathway -- PLA2 -- Cyclo-oxygenase (COX) -- Prostaglandin synthases -- Prostaglandin dehydrogenase -- Interleukin-8 -- Oxytocin Receptor -- Transcription factor activity and the onset of labour -- Cyclic AMP signalling -- Activator protein-1 and nuclear factor kappa B -- Steroid hormones -- Inhibition of NF-kappaB in the prevention of preterm delivery? -- References -- 4 Fetal outcome following preterm delivery -- Introduction -- Methodology of outcome reviews -- Description of immaturity -- Regional versus hospital-specific outcome -- Time period of study -- Denominator -- Age at death -- Growth restriction -- Multiple births -- Racial characteristics -- Lethal congenital malformations -- Follow-up compliance -- Mortality -- Major disabilities -- Overall severe disability -- Intellectual impairment -- Cerebral palsy (CP) -- Blindness -- Severe hearing impairment -- Short-term morbidity -- Chronic lung disease and home oxygen -- Retinopathy of prematurity -- Necrotising enterocolitis and feeding difficulties -- Rehospitalisation -- School age outcomes -- Chronic respiratory symptoms -- Dyspraxia -- Cognitive ability -- Behaviour -- Quality of life -- Growth -- Adolescent and adult outcomes -- Summary -- References -- 5 The prediction of preterm labour -- Risk scoring -- Cervical/vaginal secretions -- Fetal fibronectin -- Uterine activity monitoring -- Cervical ultrasound -- Endocrine factors -- Oestriol -- Corticotrophin-releasing hormone -- Relaxin -- Inflammatory cytokines -- Matrix metalloproteinase 9 (MMP-9) -- Other circulating factors -- Alpha-fetoprotein (AFP) --tidtid2179
- Format
- e-Book
- Location
- Online
