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Genetics of Rare Autoimmune Diseases

https://libcat.nshealth.ca/en/permalink/provcat44453
Javier Martín, Francisco David Carmona, editors. --Cham: Springer , c2019.
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The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major…
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Other Authors
Martín, Javier
Carmona, Francisco David
Responsibility
Javier Martín, Francisco David Carmona, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (viii, 240 p.) : 12 illus., 10 illus. in color
Series Title
Rare diseases of the immune system
ISBN
9783030039349
9783030039332 (Print ed.)
9783030039356 (Print ed.)
ISSN
2282-6505
Subjects (MeSH)
Autoimmune Diseases - genetics
Rare Diseases - genetics
Specialty
Allergy and Immunology
Genetics, Medical
Abstract
The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet’s disease, Sjogren’s syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.
Contents
1. Systemic Lupus Erythematosus -- 2. Systemic Sclerosis -- 3. Behçet’s Disease -- 4 Sjögren’s Syndrome -- 5. Polymyositis/Dermatomyositis -- 6. ANCA-Associated Vasculitis -- 7. Giant Cell Arteritis -- 8. Takayasu Arteritis -- 9. Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and Autoimmune Hepatitis -- 10. Genetics of Multiple Sclerosis -- 11. Autoimmune Myasthenia Gravis -- 12. Common Genetic Component in Autoimmunity.
Format
e-Book
Location
Online
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The New Neurotology : A Comprehensive Clinical Guide

https://libcat.nshealth.ca/en/permalink/provcat44343
by Pedro Luiz Mangabeira Albernaz, Francisco Zuma e Maia, Sergio Carmona, Renato Valério Rodrigues Cal, Guillermo Zalazar. --Cham: Springer , 2019.
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Neurotology is a branch of medicine that focuses on diagnosing and treating neurological conditions of the inner ear and related structures. There have been many recent advances in neurotology that have been published in general medicine, otolaryngology and neurology journals. This comprehensive book will aggregate this information to provide a more complete picture of the state of the field and will include the authors’ own clinical experience. There is a recent marked increase in interest in …
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Author
Albernaz, Pedro Luiz Mangabeira.
Other Authors
Zuma e Maia, Francisco.
Carmona, Sergio.
Cal, Renato Valério Rodrigues.
Zalazar, Guillermo.
Responsibility
by Pedro Luiz Mangabeira Albernaz, Francisco Zuma e Maia, Sergio Carmona, Renato Valério Rodrigues Cal, Guillermo Zalazar.
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (xix, 228 p. 76 illus., 50 illus. in color)
ISBN
9783030112837
9783030112820 (Print ed.)
9783030112844 (Print ed.)
Subjects (MeSH)
Diagnostic Techniques, Otological
Ear - innervation
Ear - physiopathology
Neurotology
Vestibular Diseases
Specialty
Neurology
Abstract
Neurotology is a branch of medicine that focuses on diagnosing and treating neurological conditions of the inner ear and related structures. There have been many recent advances in neurotology that have been published in general medicine, otolaryngology and neurology journals. This comprehensive book will aggregate this information to provide a more complete picture of the state of the field and will include the authors’ own clinical experience. There is a recent marked increase in interest in neurotology, manifested by the clinical experiences and research-publication work of otolaryngologists, neurologists, neuro-ophtalmologists, audiologists and physiotherapists. As a result, this will be a completely state-of-the-art work that includes all up-to-date neurophysiological data related to the vestibular system. It has been estimated that 10% of patients that present at an emergency clinic have vestibular disorders, including vertigo, and these disorders are frequently a cause of falls in elderly patients. On the other hand, many physicians treat their patients with vertigo with vestibular blockers, which treat the symptoms but do not cure the disorders. We feel that it is important to supply a source of information on the vestibular system and balance disorders, and this title will do that in a comprehensive manner. This title will be an ideal reference for the diagnosis and treatment of vestibular disorders for otolaryngologists, neurologists, neuro-ophtalmologists, audiologists and physiotherapists.
Contents
1. Anatomy and Clinical Physiology of the Organs of Equilibrium -- 2. The Role of the Clinical History in Neurotology -- 3. An Introduction to Vestibular Disorders -- 4. The Bedside Tests: Practical Key Strategies to the Diagnosis of Vestibular and Oculomotor Disorders -- 5. Clinical Evaluation of the Vestibular System: The Vestibular Lab Tests -- 6. The Head Impulse Tests -- 7. The Role of Audiology in Clinical Neurotology -- 8. The Vestibular Syndromes -- 9. Menière’s Disease -- 10. Vestibular Migraine -- 11. Benign Paroxysmal Positional Vertigo -- 12. Bilateral Vestibulopathy -- 13. Ataxia -- 14. Functional Vestibular Disorders -- 15. Glucose, Insulin and Inner Ear Pathology -- 16. Surgical Treatment of Vestibular Disorders.
Format
e-Book
Location
Online
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