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Immunotherapy of Cancer : An Innovative Treatment Comes of Age

https://libcat.nshealth.ca/en/permalink/provcat40389
Yoshiyuki Yamaguchi, editor. (1st ed.) --Tokyo: Springer Japan , c2016.
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This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy ha…
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Yamaguchi, Yoshiyuki
Responsibility
Yoshiyuki Yamaguchi, editor
Edition
1st ed.
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (ix, 358 p. : 46 illus., 8 illus. in color)
ISBN
9784431550310
9784431550303 (print ed.)
Subjects (MeSH)
Adjuvants, Immunologic - therapeutic use
Cancer Vaccines
Immunotherapy
Neoplasms - immunology
Neoplasms - therapy
Abstract
This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.
Contents
Part I. Overview, History, Classification -- 1. Overview of Current Cancer Immunotherapy -- Part II. BRMs and Crude Agents -- 2. Bacterial Preparations -- 3. Polysaccharides -- 4. BCG -- Part III. Cytokines -- 5. ø-T Cells -- 6. NKT Cell-Based Immunotherapy -- 7. Natural Killer Cells -- 8. þ T Cell-Based Cancer Immunotherapy -- 9. Genetically engineered T cells -- Part IV. Vaccine Therapy -- 10. Peptide Vaccine -- 11. Personalized Peptide Vaccine -- 12. WT1 Peptide Vaccine for the Treatment of Malignancies -- 13. Protein vaccine -- 14. Dendritic Cell-Based Vaccine for Cancer -- Part V. Immunoadjuvants -- 15. CpG Motif -- 16. Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy -- 17. Novel Adjuvants -- Part VI. Immunocheckpoints -- 18. Anti-CTLA-4 Ab -- 19. Anti-PD-1, PD-L1 Ab -- 20. Novel Targets of Immune Inhibitory and Stimulatory Co-signals -- Part VII. Regulation of Immunosuppression -- 21. Regulatory T Cells -- 22. MDSC: Myeloid-Derived Suppressor Cells -- Part VIII. Immune-Related Response Criteria and Guidance for Clinical Trials -- 23. Immune-Related Response Criteria and Guidance for Clinical Trials -- Part IX. Personalized Immunotherapy -- 24. Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy.
Format
e-Book
Location
Online
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Non-Invasive Sperm Selection for In Vitro Fertilization : Novel Concepts and Methods

https://libcat.nshealth.ca/en/permalink/provcat38947
Ashok Agarwal, Edson Borges Jr., Amanda S. Setti, editors. --New York, NY: Springer , c2015.
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Non-Invasive Sperm Selection for In Vitro Fertilization summarizes and discusses the relevant literature on the various advanced sperm selection methods used in modern Assisted Reproductive Technologies (ART). Chapters review some of the major unresolved issues in the field, the feasibility and success of the various sperm selection methods, their safety and the effects they have on sperm quality and ART outcomes. The book makes recommendations on clinical applications and future research, whil…
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Other Authors
Agarwal, Ashok
Borges Jr., Edson
Setti, Amanda S
Responsibility
Ashok Agarwal, Edson Borges Jr., Amanda S. Setti, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xvii, 185 p. : 45 illus., 36 illus. in color)
ISBN
9781493914111
9781493914104 (print ed.)
Subjects (MeSH)
Fertilization in Vitro
Sperm Injections, Intracytoplasmic
Sperm Retrieval
Spermatozoa - cytology
Abstract
Non-Invasive Sperm Selection for In Vitro Fertilization summarizes and discusses the relevant literature on the various advanced sperm selection methods used in modern Assisted Reproductive Technologies (ART). Chapters review some of the major unresolved issues in the field, the feasibility and success of the various sperm selection methods, their safety and the effects they have on sperm quality and ART outcomes. The book makes recommendations on clinical applications and future research, while helping to elucidate the benefits and promise of non-invasive sperm selection techniques. A distinguished team of scientists, embryologists, and urologists, with expertise in male infertility and ART, contributes to this original and valuable reference guide meant for academics, researchers, and professionals in the field of reproductive medicine who need an update on the current status of the study and practice of non-invasive sperm selection techniques.
Contents
Male Infertility Laboratory Investigation: A Critical Analysis of the 2010 World Health Organization Semen Analysis Guidelines -- Intracytoplasmic Injection with Suboptimal Spermatozoa -- Novel Sperm Tests and Their Importance -- Sperm Selection Based on Surface Electrical Charge -- Microfluidics for Sperm Selection -- Sperm Binding to Zona Pellucida, Hyaluronic Acid Binding Assay and PICSI -- Non-Apoptopic Sperm Selection -- Motile Sperm Organelle Morphology Examination (MSOME) -- Setup of Micromanipulator for Sperm Selection and Injection for IMSI -- Configuring the Microscope for Intracytoplasmic Morphology-Selected Sperm Injection (IMSI) -- The Technical Background of Advanced IMSI Systems -- Sperm Vacuoles: Origin and Implications -- MSOME: Conventional Semen Analysis, Sperm Manipulation, and Cryopreservation -- MSOME and Sperm Chromatin Status -- MSOME and Sperm DNA Integrity: Biological and Clinical Considerations -- MSOME and Sperm Chromosomal Constitution -- Intracytoplasmic Morphologically Selected Sperm Injection (IMSI): Indications and Clinical Results -- Genomic and Proteomic Approaches in the Diagnosis of Male Infertility.
Format
e-Book
Location
Online
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Quantification of Biophysical Parameters in Medical Imaging

https://libcat.nshealth.ca/en/permalink/provcat43378
Ingolf Sack, Tobias Schaeffter, editors. --Cham: Springer , c2018.
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This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative bioma…
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Other Authors
Sack, Ingolf
Schaeffter, Tobias
Responsibility
Ingolf Sack, Tobias Schaeffter, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 497 p.) : 178 illus., 130 illus. in color
ISBN
9783319659244
9783319659237 (print ed.)
9783319659251 (print ed.)
Subjects (MeSH)
Biophysical Phenomena
Diagnostic Imaging
Specialty
Diagnostic Imaging
Abstract
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.
Contents
1. Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters -- Part I. Biological and Physical Fundamentals -- 2. The Fundamentals of Transport in Living Tissues Quantified by Medical Imaging Technologies -- 3. Mathematical Modeling of Blood Flow in the Cardiovascular System -- 4. A Biphasic Poroelasticity Model for Soft Tissue -- 5. Physical Properties of Single Cells and Collective Behavior -- 6. The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging -- Part II. Medical Imaging Technologies -- 7. Mathematical Methods in Medical Image Processing -- 8. Acceleration Strategies for Data Sampling in MRI -- 9. 4D Flow MRI -- 10. CEST MRI -- 11. Innovative PET and SPECT Tracers -- 12. Methods and Approaches in Ultrasound Elastography -- 13. Photoacoustic Imaging: Principles and Applications -- 14. Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction -- Part III. Applications -- 15. Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology -- 16. Extracellular Matrix-Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms -- 17. Diffusion-Based MRI: Imaging Basics and Clinical Applications -- 18. Quantification of Functional Heterogeneities in Tumors by PET Imaging -- 19. Tumor Characterization by Ultrasound Elastography and Contrast-Enhanced Ultrasound -- 20. Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease -- 21. Radionuclide Imaging of Cerebral Blood Flow -- 22. Cardiac Perfusion MRI -- 23. Myocardial Perfusion Assessment by 3D and 4D Computed Tomography.
Format
e-Book
Location
Online
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