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Evidence-based anaesthesia and intensive care

https://libcat.nshealth.ca/en/permalink/provcat27275
edited by Ann Møller and Tom Pedersen ; project co-ordinator, Jane Cracknell. --Cambridge, UK: Cambridge University Press , 2006.
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Online
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Author
Møller, Ann
Other Authors
Pedersen, Tom
Responsibility
edited by Ann Møller and Tom Pedersen ; project co-ordinator, Jane Cracknell
Alternate Title
Evidence-based anesthesia and intensive care
Place of Publication
Cambridge, UK
Publisher
Cambridge University Press
Date of Publication
2006
Physical Description
xii, 399 p.
ISBN
6610702837 (electronic bk.)
9786610702831 (electronic bk.)
Subjects (MeSH)
Anesthesia
Evidence-Based Medicine
Contents
Cover -- Half-title -- Title -- Copyright -- Contents -- Foreword -- Contributors -- 1 Introducing evidence-based anaesthesia -- 2 How to define the questions -- Introduction -- Formulating the question -- The patient/population/problem -- The interventions/exposures considered -- The relevant outcomes -- Conclusion -- SUGGESTED READING -- 3 Developing a search strategy, locating studies and electronic databases -- Introduction -- How do you find studies that meet your review's inclusion criteria? -- Search strategy for the identification of studies -- How to develop a search strategy? -- Boolean operators: "OR" and "AND" -- Search strategies in the Cochrane Anaesthesia Review Group for the identification of studies -- Locating studies -- Electronic databases -- Where to look for studies? -- CENTRAL -- MEDLINE and EMBASE -- Should we continue to handsearch? -- Personal communication -- Document your search -- Keeping it under control -- Conclusion -- REFERENCES -- 4 Retrieving the data -- Introduction -- Stop -- Before you "start" -- Recording retrieved data -- Why extract data? -- Why record extracted data electronically? -- What data? -- Recording retrieved data electronically -- Size -- Backup -- Program -- Manipulating retrieved electronic records -- Counting -- Calculations -- Annotating and linking -- Filter and PivotTable -- Other factors that affect the validity of your answer -- Duplication -- Author networks and hubs or nodes -- Getting the data wrong -- Difficult data -- Outcome summaries but no details -- Percentages -- Solutions -- RESOURCES -- REFERENCE -- 5 Critical appraisal and presentation of study details -- Introduction -- Critical appraisal -- Study selection -- Quality assessment -- Internal and external validity -- Conflicts of interest and fraud -- Reporting standards -- Clinical trial registration -- Presentation of study details -- Summary -- REFERENCES -- 6 Outcomes -- Introduction -- Clinically relevant outcomes -- Patient satisfaction -- Other considerations -- Outcomes exemplified -- Mortality -- Morbidity -- Other anaesthesia related clinical outcomes -- Other relevant outcomes -- POEMs -- Types of trials -- The randomised controlled trial -- The cohort study (epidemiological research/regression analysis) -- Qualitative research -- Outcome related bias -- Surrogate outcome -- Conclusions -- REFERENCES -- 7 The meta-analysis of a systematic review -- Introduction -- SR data: study characteristics -- SR data: observed study outcomes -- Effect measures -- Summary effect measures and heterogeneity -- Managing heterogeneity -- Graphical tools -- Resources, problems, and promises -- Summary -- REFERENCES -- 8 Bias in systematic reviews: considerations when updating your knowledge -- Introduction -- Within-study biases/trial quality -- Bias and quality assessment in randomised controlled trials -- Selection bias: biased allocation to intervention or control group -- Performance bias: unequal care for the intervention and control group -- Information (Detection) bias: different outcome
Format
e-Book
Location
Online
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The accidental health sciences librarian

https://libcat.nshealth.ca/en/permalink/provcat33511
Lisa A. Ennis and Nicole Mitchell. --Medford, N.J.: Information Today, Inc , c2010.
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Sparked by an aging baby boomer population, the dizzying pace of breakthroughs in medical research, and an unprecedented proliferation of health information, you may soon discover a career opportunity in health sciences librarianship—if you aren’t already a part of this exciting field. In The Accidental Health Sciences Librarian, Lisa A. Ennis and Nicole Mitchell offer a thorough and up-to-date overview along with guidance on a range of critical resources, tools, and functions. Their coverage …
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Author
Ennis, Lisa A
Other Authors
Mitchell, Nicole
Responsibility
Lisa A. Ennis and Nicole Mitchell
Place of Publication
Medford, N.J.
Publisher
Information Today, Inc
Date of Publication
c2010
Physical Description
1 online resource (xvi, 213 p.)
ISBN
9781573879163
Subjects (MeSH)
Libraries, Medical - manpower - United States
Library Services - United States
Library Surveys - United States
Vocational Guidance - United States
Subjects (LCSH)
Medical librarianship - United States
Medical libraries - United States
Library surveys - United States
Libraries, Medical - manpower - United States
Library Services - United States
Library Surveys - United States
Vocational Guidance - United States
Abstract
Sparked by an aging baby boomer population, the dizzying pace of breakthroughs in medical research, and an unprecedented proliferation of health information, you may soon discover a career opportunity in health sciences librarianship—if you aren’t already a part of this exciting field. In The Accidental Health Sciences Librarian, Lisa A. Ennis and Nicole Mitchell offer a thorough and up-to-date overview along with guidance on a range of critical resources, tools, and functions. Their coverage of such essential topics as HIPAA and MeSH, along with a wealth of expert tips and advice, is a must for all new, prospective, and working health sciences librarians.
Contents
Contents: Health sciences librarianship -- Putting the medical in health sciences librarianship -- It's all about the people -- Technology -- Databases and resources -- Resources and networking.
Format
e-Book
Location
Online
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Ethical issues of human genetic databases : a challenge to classical health research ethics?

https://libcat.nshealth.ca/en/permalink/provcat50681
Elger, Bernice. --[New York, NY]: Routledge , 2010.
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Online
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Author
Elger, Bernice
Other Authors
McLean, Sheila
Place of Publication
[New York, NY]
Publisher
Routledge
Date of Publication
2010
Series Title
Medical law and ethics
ISBN
9781409404996
Subjects (MeSH)
Genetic Diseases, Inborn
Ethics, Medical
Medical Records Systems, Computerized - ethics
Notes
Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
Format
e-Book
Location
Online
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Computer Medical Databases : The First Six Decades (1950-2010)

https://libcat.nshealth.ca/en/permalink/provcat30835
Morris F. Collen. --London: Springer , c2012.
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We have witnessed the evolution of medical informatics over the past six decades as we have moved into the new information era. It is clear that computers have had and continue to have a major influence on all of medicine. Computer Medical Databases: The First Six Decades (1950-2010) has been created by Dr Collen, the "Father of Medical Informatics", to detail the journey from the very basic medical informatics databases to the hugely complex information systems that are now commonplace in cli…
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Author
Collen, Morris F
Responsibility
Morris F. Collen
Place of Publication
London
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xix, 288 p.)
Series Title
Health informatics
ISBN
9780857299628
Subjects (MeSH)
Databases as Topic - history
Medical Informatics Applications
Medical Informatics - history
Subjects (LCSH)
Telecommunication in medicine
Medical records - Data processing
Abstract
We have witnessed the evolution of medical informatics over the past six decades as we have moved into the new information era. It is clear that computers have had and continue to have a major influence on all of medicine. Computer Medical Databases: The First Six Decades (1950-2010) has been created by Dr Collen, the "Father of Medical Informatics", to detail the journey from the very basic medical informatics databases to the hugely complex information systems that are now commonplace in clinics and large hospital groups globally. The medical informatics literature for the last six decades has been so voluminous that it is unfeasible for any review to be completely comprehensive, but the historical material presented is representative of the vast changes that have been observed, and will serve as a useful bridge between medical informatics from the past into the future. The emphasis is on the development of medical informatics in the United States, but concurrent developments in Canada, Europe, and Japan have certainly influenced this field in the United States. As such, this book will be a superb addition to the library of health informaticians in the U.S. and around the world.
Contents
Chapter 1 Prologue: The Evolution of Computer Databases -- Chapter 2 The Development of Medical Databases -- Chapter 3 Processing Text in Medical Databases -- Chapter 4 Primary Medical Record Databases -- Chapter 5 Specialized Medical Databases -- Chapter 6 Secondary Medical Research Databases -- Chapter 7 Bio-Surveillance & Claims Databases -- Chapter 8 Medical Knowledge Databases -- Chapter 9 Medical Bibliographic Databases -- Chapter 10 Epilogue.
Format
e-Book
Location
Online
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Clinical Research Informatics

https://libcat.nshealth.ca/en/permalink/provcat31039
Rachel L. Richesson, James E. Andrews, editors. --London: Springer , c2012.
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Clinical research informatics (CRI) is the application of informatics principles and techniques to support the spectrum of activities and business processes that instantiate clinical research. Informatics, defined generally as the intersection of information and computer science with a health-related discipline, has a foundation drawn from many well-established, theory-based disciplines, including computer science, library and information science, cognitive science, psychology, and sociology. T…
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Other Authors
Richesson, Rachel L
Andrews, James E
Responsibility
Rachel L. Richesson, James E. Andrews, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (ix, 419 p. : 29 ill., 15 ill. in color)
Series Title
Health informatics
ISBN
9781848824485
Subjects (MeSH)
Biomedical Research - methods
Informatics
Subjects (LCSH)
Medical laboratories
Medical records - Data processing
Abstract
Clinical research informatics (CRI) is the application of informatics principles and techniques to support the spectrum of activities and business processes that instantiate clinical research. Informatics, defined generally as the intersection of information and computer science with a health-related discipline, has a foundation drawn from many well-established, theory-based disciplines, including computer science, library and information science, cognitive science, psychology, and sociology. The newly articulated yet fundamental theorem of informatics states that information technology should be used to enable humans to function and perform better together than humans alone, and so informatics is a source for supportive technologies and tools that enhance--but not replace--unreservedly human processes. Clinical Research Informatics contributes to the ongoing dialogues among researchers and practitioners in CRI as they continue to rise to the challenges of a dynamic and evolving clinical research environment. The development of CRI as a sub-discipline of informatics, and as an independent/maturing professional practice area in its own right, drives a growing pool of scientific literature based on original CRI research, and high-impact tools and systems will be developed. CRI leaders and stakeholder groups will continue to support and create communities of discourse that will address much needed practice standards in CRI, improved safety and efficiencies in clinical research, data standards in clinical research, policy issues, educational standards and instructional resources. The Editors and contributors to this book are among the most active and engaged in the CRI domain and provide an excellent primer for deeper explorations into this emerging discipline. Certain themes are highlighted, including the changing role of the consumer, movement toward transparency, growing needs for global coordination and cooperation on many levels, and the merging together of clinical care delivery and research as part of a changing paradigm in global healthcare delivery--all in the context of rapid innovations in technology and explosions of data sources, types, and volume. This book is therefore of considerable interest to all students of biomedical informatics, from the newcomer to the professional informatician.
Contents
Section I: Contexts of Clinical Research Informatics -- Introduction to Clinical Research Informatics -- From Notations to Data: The Digital Transformation of Clinical Research -- Clinical Research Environment. - Statistical and Study Design Foundations of Clinical Research -- Informatics Approaches to Participant Recruitment -- The Evolving Role of Consumers -- Clinical Research in the Post-Genomic Era -- Section II: Data Management and Systems in Clinical Research -- Clinical Research Information Systems -- Study Protocol Representation -- Data Quality in Clinical Research -- Patient-Reported Outcome Data -- Biobanking Challenges and Informatics Opportunities -- Patient Registries -- Section III: Knowledge Representation and Discovery -- Knowledge Representation and Ontologies -- Non-hypothesis Driven Research: Data Mining and Knowledge Discovery -- Natural Language Processing, Electronic Health Records, and Clinical Research -- Section IV: The Future of Clinical Research, Health, and Clinical Research Informatics -- Data Sharing: Electronic Health Records and Research Interoperability -- Standards Development and the Future of Research Data Sources, Interoperability, and Exchange -- Pharmacovigilance -- Clinical Trials Registries and Results Databases -- Future Directions in Clinical Research Informatics -- Index.
Format
e-Book
Location
Online
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Molecular diagnostics and treatment of pancreatic cancer : systems and network biology approaches

https://libcat.nshealth.ca/en/permalink/provcat33143
edited by Asfar S. Azmi. --Amsterdam, Netherlands: Elsevier/AP , 2014.
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Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expres…
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Other Authors
Azmi, Asfar S
Responsibility
edited by Asfar S. Azmi
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier/AP
Date of Publication
2014
Physical Description
1 online resource (xx, 446 p.)
ISBN
9781306642347 (electronic bk)
Subjects (MeSH)
Pancreatic Neoplasms - diagnosis
Molecular Diagnostic Techniques
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - therapy
Signal transduction
Tumor Markers, Biological
Subjects (LCSH)
Pancreas - Cancer - Molecular diagnosis
Pancreas - Cancer - Treatment
Pancreatic Neoplasms - diagnosis
Molecular Diagnostic Techniques
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - therapy
Signal Transduction
Tumor Markers, Biological
Abstract
Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets.
Contents
Front Cover; MOLECULAR DIAGNOSTICS AND TREATMENT OF PANCREATIC CANCER: SYSTEMS AND NETWORK BIOLOGY APPROACHES; Copyright; DEDICATION; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; Section I -- Current Trends and Advances in Pancreatic Cancer; Chapter 1 -- Epidemiology, Treatment, and Outcome of Pancreatic Cancer; INTRODUCTION; EPIDEMIOLOGY AND ETIOLOGY OF PANCREATIC CANCER; TYPES OF PANCREATIC CANCER; CLINICAL PRESENTATION OF PANCREATIC CANCER; DIAGNOSIS OF PANCREATIC CANCER; TREATMENT OF PANCREATIC CANCER; POTENTIALLY CURATIVE SURGICAL TREATMENT; ADJUVANT AND NEOADJUVANT TREATMENT -- PROGNOSIS OF PANCREATIC CANCEROUTLOOK; REFERENCES; Chapter 2 -- Advances in Primary Cell Culture of Pancreatic Cancer; INTRODUCTION; CELL CULTURE OF PDAC; ISOLATION AND ESTABLISHMENT PROCEDURE; CHARACTERIZATION OF CELL CULTURES; MORPHOLOGY; GENOTYPING; PHENOTYPING; SECOND LEVEL OF BIOLOGICAL MODELS; THREE-DIMENSIONAL CELL CULTURES; IN VIVO MODELS; APPLICATIONS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 3 -- Multimodal Therapies for Pancreatic Cancer; INTRODUCTION; CONCLUSION; REFERENCES; Chapter 4 -- The Role of Notch Signaling Pathway in the Progression of Pancreatic Cancer; INTRODUCTION -- NOTCH SIGNALING PATHWAYTHE ROLE OF NOTCH IN PC; NOTCH INHIBITION IS A NOVEL STRATEGY FOR PC TREATMENT; UNDERSTANDING NOTCH SIGNALING THROUGH SYSTEMS BIOLOGY; CONCLUSION; REFERENCES; Section II -- Gene Expression Profiling and Bioinformatics Analysis in Pancreatic Cancer; Chapter 5 -- Bioinformatics Analysis of Pancreas Cancer Genome in High-Throughput Genomic Technologies; INTRODUCTION; HETEROGENEITY AND QUALITY OF SAMPLES FOR HIGH-THROUGHPUT GENOMIC TECHNOLOGIES; MICROARRAYS; NEXT-GENERATION SEQUENCING; DATABASES AND RESOURCES; CONCLUSION AND FUTURE PERSPECTIVES; ACKNOWLEDGEMENTS; REFERENCES -- Chapter 6 -- Statistical Analysis of High-Dimensional Data for Pancreatic CancerINTRODUCTION; LASSO PENALIZED COX REGRESSION; DOUBLY REGULARIZED COX REGRESSION; PANCREATIC CANCER SURVIVAL ANALYSIS; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 -- Gene Expression Profiling in Pancreatic Cancer; INTRODUCTION; SUMMARY; REFERENCES; Chapter 8 -- Genetic Susceptibility and Risk of Pancreatic Cancer; INTRODUCTION; FAMILIAL RISK OF PANCREATIC CANCER; RARE, HIGH-RISK PANCREATIC CANCER SUSCEPTIBILITY GENES AND MULTICANCER SYNDROMES; COMMON, LOW-RISK PANCREATIC CANCER SUSCEPTIBILITY LOCI -- COMMON PANCREATIC CANCER RISK LOCI IN NON-EUROPEAN POPULATIONSPATHWAY ANALYSES OF PANCREATIC CANCER GWAS DATA SETS; FUTURE GWAS AND GENE MAPPING APPROACHES; WEBSITES; REFERENCES; Section III -- Pancreatic Cancer Proteomics; Chapter 9 -- Proteomics in Pancreatic Cancer Translational Research; INTRODUCTION; OVERVIEW OF PROTEOMICS TECHNOLOGIES; PROTEOMICS STUDY OF PANCREATIC TISSUE; BLOOD BIOMARKER DISCOVERY; ANALYSIS OF PANCREATIC JUICE AND CYST FLUID; FUNCTIONAL AND HYPOTHESIS-DRIVEN PROTEOMIC STUDIES; POST-TRANSLATIONAL MODIFICATIONS; SUMMARY; ACKNOWLEDGMENT; REFERENCES -- Chapter 10 -- Proteomic Differences and Linkages between Chemoresistance and Metastasis of Pancreatic Cancer Using Knowledge-Based Pathway Analysis.
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Practical informatics for cytopathology

https://libcat.nshealth.ca/en/permalink/provcat33424
Liron Pantanowitz, Anil V. Parwani, editors. --New York: Springer , c2014.
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Practical Informatics for Cytopathology provides a concise and practical overview of pathology informatics. The book offers a succinct overview of basic computing and laboratory information systems applied specifically to the field of cytopathology. Readers are exposed to emerging areas in pathology informatics, such as specimen tracking and digital imaging. Valuable features of this volume include summary tables, diagrams, vital resources and a glossary of informatics terms to help readers. Wr…
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Other Authors
Pantanowitz, Liron
Parwani, Anil V
Responsibility
Liron Pantanowitz, Anil V. Parwani, editors
Place of Publication
New York
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xvi, 204 pages)
Series
Essentials in cytopathology
Series Vol.
v. 14
Series Title
Essentials in cytopathology series
ISBN
9781461495819 (electronic bk.)
9781461495802
Subjects (MeSH)
Cytodiagnosis
Medical Informatics
Clinical Laboratory Information Systems
Subjects (LCSH)
Medical informatics
Pathology, Cellular
Abstract
Practical Informatics for Cytopathology provides a concise and practical overview of pathology informatics. The book offers a succinct overview of basic computing and laboratory information systems applied specifically to the field of cytopathology. Readers are exposed to emerging areas in pathology informatics, such as specimen tracking and digital imaging. Valuable features of this volume include summary tables, diagrams, vital resources and a glossary of informatics terms to help readers. Written by authorizes in the field, Practical Informatics for Cytopathology is a vital resource that provides users with a solid, comprehensive foundation and practical working knowledge of the rapidly emerging field of pathology informatics.
Contents
Introduction to Informatics -- Basic Computing -- Networking -- Databases -- Coding -- Laboratory Information Systems -- Laboratory Information System Operations and Regulations -- Reporting -- Quality Management -- Barcoding -- Informatics Projects -- Lean Six Sigma -- Electronic Medical Records -- Digital Imaging -- Automated Pap Tests -- Telecytology -- Cytology Online -- Bioinformatics -- Research Informatics -- Appendix A. Key Definitions -- Appendix B. Recommended Reading.
Format
e-Book
Location
Online
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Understanding evidence-based rheumatology : a guide to interpreting criteria, drugs, trials, registries, and ethics

https://libcat.nshealth.ca/en/permalink/provcat33465
Hasan Yazici, Yusuf Yazici, Emmanuel Lesaffre, editors. --Cham, Switzerland: Springer , c2014.
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It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics, and application of data t…
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Other Authors
Yazici, Hasan
Yazc, Yusuf
Lesaffre, Emmanuel
Responsibility
Hasan Yazici, Yusuf Yazici, Emmanuel Lesaffre, editors
Place of Publication
Cham, Switzerland
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xii, 276 pages)
ISBN
9783319083742 (electronic bk.)
9783319083735
Subjects (MeSH)
Rheumatology
Evidence-Based Medicine
Subjects (LCSH)
Rheumatology
Evidence-based medicine - methods
Abstract
It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics, and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology, and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined, and the book closes with a summary of future directions for scientific and clinical studies in rheumatology. Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, experienced clinicians, and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.
Contents
Evidence-Based Medicine in Rheumatology: How Does It Differ from Other Diseases? -- A Review of Statistical Approaches for the Analysis of Data in Rheumatology -- Disease Classification/Diagnosis Criteria -- Biomarkers, Genetic Association and Genomic Studies -- Outcome Measures in Rheumatoid Arthritis -- Issues in Setting Up a Study and Data Collection -- The Randomized Controlled Trial: Methodological Perspectives -- Limitations of Traditional Randomized Controlled Clinical Trials in Rheumatology -- Methodological Issues Relevant to Observational Studies, Registries and Administrative Health Databases in Rheumatology -- Systematic Reviews and Meta-analyses in Rheumatology -- Ethical Issues in Study Design and Reporting -- Future Directions.
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e-Book
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Decision tools for radiation oncology : prognosis, treatment response and toxicity

https://libcat.nshealth.ca/en/permalink/provcat33587
Carsten Nieder, Laurie E. Gasper, editors. --Heidelberg: Springer , c2014.
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A look at the recent oncology literature or a search of one of the common databases reveals a steadily increasing number of nomograms and other prognostic models, some of which are also available in the form of web-based tools. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, et cetera Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment …
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Other Authors
Nieder, C
Gasper, Laurie E
Responsibility
Carsten Nieder, Laurie E. Gasper, editors
Place of Publication
Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xiii, 305 pages)
Series
Medical radiology. Radiation oncology
Series Title
Medical radiology (Series)
ISBN
9783642371028 (electronic bk.)
9783642371011
Subjects (MeSH)
Clinical Decision-Making
Decision Support Techniques
Individualized Medicine
Nomograms
Radiotherapy - methods
Treatment Outcome
Abstract
A look at the recent oncology literature or a search of one of the common databases reveals a steadily increasing number of nomograms and other prognostic models, some of which are also available in the form of web-based tools. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, et cetera Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment concepts and also the need for approaches that achieve a favorable balance between effectiveness and side-effects. Moreover, optimal resource utilization requires prognostic knowledge, for example to avoid lengthy and aggressive treatment courses in patients with a short survival expectation. In order to avoid misuse, it is important to understand the limits and caveats of prognostic and predictive models. This book provides a comprehensive overview of such decision tools for radiation oncology, stratified by disease site, which will enable readers to make informed choices in daily clinical practice and to critically follow the future development of new tools in the field.
Contents
Prognosis and predictive factors for tumours and organs at risk: background and purpose -- Specific issues for prognostic factors related to radiotherapy -- Role of ICT in decision models -- Statistics of prediction of survival and toxicity and nomogram development -- Treatment decisions based on gene signatures: methods and caveats -- Brain tumors -- Head and neck cancer -- Breast cancer -- Lung cancer -- Esophageal cancer -- Gastric cancer -- Pancreas and biliary tract cancer -- Liver cancer and metastases -- Rectal and anal cancer -- Cervix and corpus uteri, vulva and vaginal cancers -- Bladder cancer -- Prostate cancer -- Sarcomas -- Lymphomas -- Brain metastases -- Bone metastases.
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e-Book
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Implementing web-scale discovery services : a practical guide for librarians

https://libcat.nshealth.ca/en/permalink/provcat33747
JoLinda Thompson. --Lanham, MD: Rowman and Littlefield , c2014.
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Online
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Author
Thompson, JoLinda
Responsibility
JoLinda Thompson
Place of Publication
Lanham, MD
Publisher
Rowman and Littlefield
Date of Publication
c2014
Physical Description
1 online resource, 159 p.
Series Vol.
9
Series Title
Practical guides for librarians
ISBN
9780810891272
Subjects (MeSH)
Library Technical Services
Internet
Information Storage and Retrieval
Libraries, Digital
Online Systems
User-Computer Interface
Subjects (LCSH)
Online library catalogs
Online bibliographic searching
Federated searching
Library Web sites
Library catalogs and users
User interfaces (Computer systems)
Libraries - Special collections - Electronic information resources
Catalogs, Library
Databases, Bibliographic
Internet
User-Computer Interface
Contents
The evolution of Web-scale discovery in libraries -- A closer look at Web-scale discovery options -- Making the best content match for your library -- Evaluating the discovery layer -- Other important Web-scale discovery service features and functions -- Selecting and purchasing a Web-scale discovery service -- Configuring system content integration and customization for local needs -- Configuring and branding the discovery layer -- Introducing the service to users -- Usability testing of Web-scale discovery services -- Maintaining a Web-scale discovery service -- The future of Web-scale discovery.
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e-Book
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Online
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Success in academic surgery : health services research

https://libcat.nshealth.ca/en/permalink/provcat34037
Justin B. Dimick, Caprice C. Greenberg, editors. --London: Springer , c2014.
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Success in Academic Surgery: Health Services Research is a unique handbook which will help researchers and surgeons in obtaining National Institutes of Health funding and other grants, as well as breaking through the barriers to developing a career in academic surgery. Aimed at surgical residents and young surgical faculty, Success in Academic Surgery: Health Services Research is written by expert authors from around the world who are members of the Association for Academic Surgery, and it offe…
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Other Authors
Dimick, Justin B.
Greenberg, Caprice C.
Responsibility
Justin B. Dimick, Caprice C. Greenberg, editors
Alternate Title
Health services research
Place of Publication
London
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xv, 292 pages)
Series Title
Success in academic surgery
ISBN
9781447147183 (electronic bk.)
9781447147176
Subjects (MeSH)
General Surgery
Health Services Research
Outcome Assessment, Health Care
Quality Assurance, Health Care
Surgical Procedures, Operative
Subjects (LCSH)
Surgery - Research
Abstract
Success in Academic Surgery: Health Services Research is a unique handbook which will help researchers and surgeons in obtaining National Institutes of Health funding and other grants, as well as breaking through the barriers to developing a career in academic surgery. Aimed at surgical residents and young surgical faculty, Success in Academic Surgery: Health Services Research is written by expert authors from around the world who are members of the Association for Academic Surgery, and it offers a practical and personal insight on working in academic surgery.
Contents
Part I. Main Research Areas -- An Introduction to Health Services Research -- Comparative Effectiveness Research -- Understanding Variations in the Use of Surgery -- Health Policy Research in Surgery -- Studying Surgical Disparities: It's Not All Black and White -- Measuring Health Care Quality in Surgery: Strategies, Limitations, and Currently Available Initiatives -- Using Data for Local Quality Improvement -- Part II. Emerging Areas of Research -- Implementation Science and Quality Improvement -- Understanding and Changing Organizational Culture in Surgery -- Assessing Patient-Centered Outcomes -- Studying What Happens in the OR -- Collaborative Quality Improvement -- Part III. Tools of the Trade -- Large Databases Used for Outcomes Research -- Methods for Enhancing Causal Inference in Observational Studies -- Systematic Review and Meta-analysis: A Clinical Exercise -- Medical Decision-Making Research in Surgery -- Survey Research -- Qualitative Research Methods -- Part IV. Career Development -- Engaging Students in Surgical Outcomes Research -- Finding a Mentor in Outcomes Research -- What Every Outcomes Research Fellow Should Learn -- Funding Opportunities for Outcomes Research -- Choosing Your First Job as a Surgeon and Health Services Researcher -- Building a Health Services Research Program.
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e-Book
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Pediatric and Congenital Cardiac Care. Volume 1, Outcomes Analysis

https://libcat.nshealth.ca/en/permalink/provcat38901
Paul R. Barach, Jeffery P. Jacobs, Steven E. Lipshultz, Peter C. Laussen, editors. --London: Springer , c2015.
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This book is the first in a two-volume set of textbooks and focuses on outcomes analysis in pediatric cardiac care, supporting the coverage of quality improvement and patient safety in its sister title. There has been a huge research effort undertaken in pediatric and congenital cardiac care to understand and measure what is done, to establish collaborative definitions and tools of measurement, and to determine robust benchmarks and methodologies to analyze outcomes. This book concentrates on i…
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Barach, Paul R
Jacobs, Jeffery P
Lipshultz, Steven E
Laussen, Peter C
Responsibility
Paul R. Barach, Jeffery P. Jacobs, Steven E. Lipshultz, Peter C. Laussen, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xxii, 515 p. : 100 illus., 52 illus. in color)
ISBN
9781447165873
9781447165866 (print ed.)
Subjects (MeSH)
Data Collection
Heart Diseases - therapy
Outcome Assessment, Health Care
Quality Improvement
Statisitics as Topic
Abstract
This book is the first in a two-volume set of textbooks and focuses on outcomes analysis in pediatric cardiac care, supporting the coverage of quality improvement and patient safety in its sister title. There has been a huge research effort undertaken in pediatric and congenital cardiac care to understand and measure what is done, to establish collaborative definitions and tools of measurement, and to determine robust benchmarks and methodologies to analyze outcomes. This book concentrates on implementation science in terms of continuous quality improvements and safety science and systems. Pediatric and Congenital Cardiac Care: Volume 1, Outcomes Analysis reveals the remarkable developments that have been seen in the fields of pediatric cardiology and cardiac surgery. This unique collaboration between four Editors from disparate medical disciplines (cardiac surgery, cardiology, anesthesia, and critical care) incorporates an international community of scholarship with articles by luminaries and cutting edge thinkers on the current and future status of pediatric and congenital cardiac care. The goal of this and its companion volume is to understand and advance the profession and its activities, to use common terms, and to improve the management of risk and safety in order to enhance pediatric and congenital cardiac care.
Contents
Part I Introduction -- 1 Introduction -- 2 Introduction: The History of Statistics in Medicine and Surgery -- 3 Introduction: Using Data to Drive Change and Improvement: The Legacy of Florence Nightingale -- 4 Introduction: Quality Improvement and Databases in the Context of Professionalism -- Part II Nomenclature and Taxonomies -- 5 Nomenclature for Congenital and Pediatric Cardiac Disease: Historical Perspectives and the International Pediatric and Congenital Cardiac -- 6 Defining Terms in Lists of Nomenclature -- 7 Illustrating Terms in Lists of Nomenclature -- Part III Databases 8 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Cardiac Surgery -- 9 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Cardiology -- 10 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Anesthesia -- 11 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Critical Care -- 12 Early Database Initiatives: The Fyler Codes -- 13 The Academic Database: Lessons Learned from the Congenital Heart Surgeons’ Society Data Center -- 14 Clinical Versus Administrative Data -- 15 Databases for Pediatric Cardiac Transplantation: The United Network for Organ Sharing/Scientific Registry of Transplant Recipients (UNOS/SRTR) and the Pediatric Heart Transplant Study (PHTS) -- 16 Databases for Extracorporeal Membrane Oxygenation and Ventricular Assist Devices -- 17 The United Kingdom National Congenital Heart Disease Audit -- 18 The Pediatric Cardiac Care Consortium: The End of an Era and Beginning of a New Mission -- 19 Pediatric Cardiac Catheterization Databases -- 20 Pediatric Electrophysiology Databases -- 21 Using Data to Drive Improvement and Build the Science of Nursing -- 22 Data Standards of the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) and the Universal Pediatric Cardiac Dataset -- 23 Ethical Issues Confronting Outcomes Analysis and Quality Assurance -- Part IV Stratification of Complexity -- 24 Statistical Issues in the Analysis and Interpretation of Outcomes for Congenital Cardiac Surgery -- 25 Real Time Monitoring of Risk- Adjusted Surgical Outcomes for Congenital Heart Disease -- 26 Risk Adjustment for Congenital Heart Surgery -1 (RACHS-1) for Evaluation of Mortality in Children Undergoing Cardiac Surgery -- 27 The Aristotle Complexity Score: A Tool to Evaluate Performance in Congenital Heart Surgery -- 28 Empirically Based Tools for Analyzing Mortality and Morbidity Associated with Congenital Heart Surgery -- Part V Verifi cation of Data Completeness and Accuracy of Data -- 29 Verification of Data Completeness and Accuracy -- Part VI Subspecialty Collaboration -- 30 Linking Databases -- Part VII Longitudinal Follow-Up -- 31 Use of National Death Registries to Empower Databases in Reporting Longitudinal Follow-Up -- 32 Quality of Life: The Need for a National Database -- 33 Longitudinal Follow-Up Studies in the Pediatric Heart Network -- 34 The Value of National Institutes of Health (NIH) Registry-Based Research in Identifying Childhood Cardiac Disease Outcomes: The Pediatric Cardiomyopathy Registry Experience -- Part VIII Public Reporting of Data -- 35 Public Reporting of Cardiac Data: Pros, Cons, and Lessons for the Future -- 36 Public Reporting of Pediatric Cardiac Data -- 37 Communication Chaos: How Incomplete and Conflicting Information Prevents Improved Outcomes for Patients with Pediatric and Congenital Cardiac Disease (and What We Can Do About It) -- Index.
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The History of Medical Informatics in the United States

https://libcat.nshealth.ca/en/permalink/provcat38913
Morris F. Collen, Marion J. Ball, editors. (Second edition) --London: Springer , c2015.
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This is a meticulously detailed chronological record of significant events in the history of medical informatics and their impact on direct patient care and clinical research, offering a representative sampling of published contributions to the field. The History of Medical Informatics in the United States has been restructured within this new edition, reflecting the transformation medical informatics has undergone in the years since 1990. The systems that were once exclusively institutionally …
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Other Authors
Collen, Morris F
Ball, Marion J
Responsibility
Morris F. Collen, Marion J. Ball, editors
Edition
Second edition
Place of Publication
London
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xxii, 755 p.)
Series Title
Health informatics
ISBN
9781447167327
9781447167310 (print ed.)
ISSN
1431-1917
Subjects (MeSH)
Informatics - history
Medical Informatics - history
Other Subjects
United States
Abstract
This is a meticulously detailed chronological record of significant events in the history of medical informatics and their impact on direct patient care and clinical research, offering a representative sampling of published contributions to the field. The History of Medical Informatics in the United States has been restructured within this new edition, reflecting the transformation medical informatics has undergone in the years since 1990. The systems that were once exclusively institutionally driven--hospital, multihospital, and outpatient information systems--are today joined by systems that are driven by clinical subspecialties, nursing, pathology, clinical laboratory, pharmacy, imaging, and more. At the core is the person--not the clinician, not the institution--whose health all these systems are designed to serve. A group of world-renowned authors have joined forces with Dr Marion Ball to bring Dr Collen's work to press. These recognized leaders in medical informatics, many of whom are recipients of the Morris F. Collen Award in Medical Informatics and were friends of or mentored by Dr Collen, carefully reviewed, editing and updating his draft chapters. This has resulted in the most thorough history of the subject, and also provides readers with a roadmap for the subject well into later in the century.
Contents
The Development of Digital Computers -- The Creation of a New Discipline -- evelopment of Medical Information Systems (MISs) -- Medical Databases and Patient Record Systems -- Outpatient Information Systems (OISs) for Ambulatory Care -- The Early History of Hospital Information Systems -- Nursing Informatics: Past, Present, and Future -- Specialized High-Intensity Clinical Settings: A Brief Review -- Information Systems for Clinical Subspecialties -- Multi-Hospital Information Systems (MHISs) -- Clinical Support Information Systems (CSISs) -- Clinical Laboratory (LAB) Information Systems -- Anatomic Pathology Information Laboratory Information Systems and Natural Language Processing: Early History -- Pharmacy Information (PHARM) Systems -- Imaging Information Systems -- Public and Personal Health Testing Systems -- Decision Support Systems -- Medical Informatics: Past and Future.
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e-Book
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Mesenteric Vascular Disease : Current Therapy

https://libcat.nshealth.ca/en/permalink/provcat38981
Gustavo S. Oderich, editor. --New York, NY: Springer , c2015.
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This book represents the first comprehensive textbook devoted to the standard of care, current guidelines and innovations in the field of mesenteric vascular disease. The book reviews imaging modalities, diagnostic work up, physiologic tests, traditional open surgical techniques and novel endovascular approaches. Technical aspects of both open surgical and endovascular techniques are provided by experts in the field, with illustrations and photographs of key steps for each type of procedure. Re…
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Other Authors
Oderich, Gustavo S
Responsibility
Gustavo S. Oderich, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xviii, 468 p. : 155 illus., 101 illus. in color)
ISBN
9781493918478
9781493918461 (print ed.)
Subjects (MeSH)
Mesenteric Arteries - pathology
Mesenteric Ischemia - therapy
Mesenteric Vascular Occlusion - therapy
Mesenteric Veins - pathology
Abstract
This book represents the first comprehensive textbook devoted to the standard of care, current guidelines and innovations in the field of mesenteric vascular disease. The book reviews imaging modalities, diagnostic work up, physiologic tests, traditional open surgical techniques and novel endovascular approaches. Technical aspects of both open surgical and endovascular techniques are provided by experts in the field, with illustrations and photographs of key steps for each type of procedure. Results of epidemiologic studies and national databases are summarized, as well as large institutional experiences. An evidence-based approach is used for recommendations regarding best therapies. Diagnostic approaches including imaging and novel physiologic tests, including gastric tonometry and oxygen light spectroscopy are also covered. Mesenteric Vascular Disease: Current Therapy will serve as a very useful resource for clinicians, surgeons, interventionalists, gastroenterologists and researchers dealing with and interested in mesenteric vascular diseases.
Contents
History of Mesenteric Vascular Disease -- Normal and Variant Mesenteric Anatomy -- Pathophysiology -- Epidemiology and Natural History -- Duplex Ultrasound of the Mesenteric Vessels -- Functional Testing in the Diagnosis of Chronic Mesenteric Ischemia -- Non-invasive Arterial Imaging: Computed Tomography and Magnetic Resonance Angiography -- Diagnostic Angiography -- Clinical Presentation, Etiology, and Diagnostic Considerations -- Non-Atherosclerotic Causes of Mesenteric Arterial Disease -- Techniques of Open Mesenteric Reconstructions -- Results of Open Mesenteric Reconstructions -- Techniques of Endovascular Mesenteric Revascularization -- Results of Endovascular Mesenteric Revascularization -- Clinical Presentation, Etiology, and Diagnostic Considerations -- Technique of Open Mesenteric Catheter Embolectomy -- Techniques of Open and Hybrid Mesenteric Revascularization for Acute Mesenteric Ischemia -- Techniques of Endovascular Revascularization for Acute Mesenteric Ischemia -- Second Look Laparotomy, the Open Abdomen, and Temporary Abdominal Closure in Acute Mesenteric Ischemia -- Results of Open and Endovascular Revascularization for Acute Mesenteric Ischemia -- Medical Management of Short Bowel Syndrome and Nutritional Support -- Clinical Presentation, Etiology, and Diagnostic Considerations -- Thrombophilia Testing in Splanchnic Vein Thrombosis -- Treatment of Mesenteric Venous Thrombosis -- Clinical Presentation and Diagnosis -- Management and Results -- Clinical Presentation and Diagnostic Considerations -- Open Surgical Treatment -- Laparoscopic Trans-peritonaeal Approach -- Results of Open and Laparoscopic Median Arcuate Ligament Release -- Clinical Presentation, Etiology, and Diagnostic Considerations of Isolated Visceral Artery Dissections -- Open Surgical and Endovascular Revascularizations of Isolated Visceral Artery Dissections -- Results of Medical, Interventional, and Surgical Treatment -- Clinical Presentation, Etiology, Diagnostic Considerations, Treatment, and Results.
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e-Book
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Biomarkers in Neoplastic Neuropathology

https://libcat.nshealth.ca/en/permalink/provcat39834
Fausto Rodriguez, Cheng-Ying Ho. --Cham: Springer , c2016.
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This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and …
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Author
Rodriguez, Fausto
Other Authors
Ho, Cheng-Ying
Responsibility
Fausto Rodriguez, Cheng-Ying Ho
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (x, 98 p. : 31 illus., 1 illus. in color)
ISBN
9783319209319
9783319209302 (print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Nervous System Neoplasms - physiopathology
Abstract
This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on biobanking covers the equally important topic of optimal preservation of tissue and includes consideration of ethical considerations raised by the use of tissue obtained in clinical settings. The closing section discusses the major categories of neoplastic disorders involving the nervous system, with emphasis on diagnostic, prognostic, and predictive biomarkers used in the pathologic evaluation of different types of brain tumor.
Contents
Introduction -- Special Techniques -- Biobanking and Regulations -- Public Databases -- Biomarkers applied to specific tumor types.
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e-Book
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Surgery of Conotruncal Anomalies

https://libcat.nshealth.ca/en/permalink/provcat39901
Francois Lacour-Gayet, Edward L. Bove, Viktor Hraška, Victor O. Morell, Thomas L. Spray, editors. --Cham: Springer , c2016.
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This book addresses the most technically demanding cardiac surgical techniques, many of which are often performed on small infants. Conotruncal heart defects are a group of congenital anomalies of the cardiovascular system that are a leading cause of symptomatic cyanotic cardiac disease diagnosed in utero. Surgery of Conotruncal Anomalies provides a wealth of practical information and has been written by a collection of world renowned experts. They discuss the most challenging but life-changing…
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Other Authors
Lacour-Gayet, Francois
Bove, Edward L
Hraška, Viktor
Morell, Victor O
Spray, Thomas L
Responsibility
Francois Lacour-Gayet, Edward L. Bove, Viktor Hraška, Victor O. Morell, Thomas L. Spray, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xvii, 627 p. : 290 illus., 186 illus. in color)
ISBN
9783319230573
9783319230566 (print ed.)
Subjects (MeSH)
Cardiovascular Surgical Procedures
Heart Defects, Congenital - surgery
Abstract
This book addresses the most technically demanding cardiac surgical techniques, many of which are often performed on small infants. Conotruncal heart defects are a group of congenital anomalies of the cardiovascular system that are a leading cause of symptomatic cyanotic cardiac disease diagnosed in utero. Surgery of Conotruncal Anomalies provides a wealth of practical information and has been written by a collection of world renowned experts. They discuss the most challenging but life-changing surgeries which, if performed perfectly, allow the child to lead a normal adult life in the majority of cases. This book and the large number of truly stunning explanatory illustrations contained within is an essential resource for junior surgeons as well as trainees and practicing cardiac surgeons, pediatric cardiologists and surgeons, and cardiac imagers, to be used as a critical reference when performing these complex cases.
Contents
1. Definition of Conotruncal Anomalies -- 2. Development and Maldevelopment of the Ventricular Outflow Tracts -- 3. Anatomy of Conotruncal Anomalies -- 4. Outcomes Data of Surgery for Conotruncal Anomalies from the Congenital EACTS and STS Databases -- 5. Tetralogy of Fallot: Transventricular Repair, Including Pulmonary Atresia Without MAPCAs -- 6. Transatrial Repair of Tetralogy of Fallot -- 7. Tetralogy of Fallot: Management of the Pulmonary Valve -- 8. Pulmonary Atresia, Ventricular Septal Defect and Major Aorto-Pulmonary Collateral Arteries -- 9. Tetralogy of Fallot with Complete Atrioventricular Canal -- 10. Tetralogy of Fallot with Absent Pulmonary Valve Syndrome -- 11. Fallot: Palliation with BT Shunt -- 12. Redo Fallot: Surgery for Pulmonary Valve Implantation -- 13. Transcatheter Pulmonary Valvulation -- 14. Arterial Switch in TGA-IVS: Coronary Transfer -- 15. Arterial Switch for TGA or DORV and VSD, with and Without Aortic Arch Obstruction -- 16. TGA-IVS and TGA-VSD Seen Late -- 17. TGA-VSD and LVOTO: Rastelli Procedure -- 18. TGA-VSD-LVOT Obstruction : REV (Réparation à l’Etage Ventriculaire) Procedure -- 19. Transposition of the Great Arteries with VSD and LVOTO. The Autograft Procedure for RVOT (the “DREAM”) -- 20. The Aortic Translocation (Nikaidoh) Procedure -- 21. Double Root Translocation Operation for Complete Transposition of Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis & Double-Outlet Right Ventricle with Non-committed Ventricular Septal Defect and Pulmonary -- 22. Transposition of the Great Arteries with Ventricular Septal Defect and Left Ventricle Outflow Tract Obstruction: Pulmonary Valve Translocation -- 23. Bi-ventricular Repair of Double Outlet Right Ventricle -- 24. Biventricular Repair of Double Outlet Right Ventricle with Complete Atrioventricular Septal Defect -- 25. Double Outlet Left Ventricle -- 26. Corrected TGA-VSD: The Double Switch Procedure -- 27. Anatomic Correction of Corrected Transposition of the Great Arteries with Ventricular Septal Defect and Obstruction of the Left Ventricular Outflow Tract -- 28. Corrected TGA-VSD-LVOTO: Rastelli + Atrial Switch + Damus-Kaye-Stansel Operation -- 29. Physiologic Repair of Congenitally Corrected Transposition of the Great Arteries -- 30. Anatomically Corrected Malposition of the Great Arteries -- 31. Truncus Arteriosus -- 32. Common Arterial Trunk with Interrupted Aortic Arch -- 33. Interrupted Aortic Arch -- 34. The Dilated Aortic Root in Adult Patients with Conotruncal Anomalies -- 35. Single Ventricle Repair for Conotruncal Anomalies -- 36. Genetics of Conotruncal Anomalies.
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e-Book
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Online
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Applying Comparative Effectiveness Data to Medical Decision Making : A Practical Guide

https://libcat.nshealth.ca/en/permalink/provcat39912
Carl Asche, editor. --Cham: Springer International Publishing : Imprint: Adis , c2016.
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This textbook introduces students to the basic concepts and methods used to measure and compare the expected benefits, risks and cost of preventive and therapeutic medical interventions. It provides an easily accessible overview of comparative effectiveness and its practical applications to daily medical decisions. The book includes learning objectives for each topic, definitions of key terms and topic summaries. Each chapter is written by a highly regarded academic and extensive reference is m…
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Other Authors
Asche, Carl
Responsibility
Carl Asche, editor
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Adis
Date of Publication
c2016
Physical Description
1 online resource (viii, 113 p. : 16 illus., 12 illus. in color)
ISBN
9783319233291
9783319220642 (print ed.)
Subjects (MeSH)
Clinical Decision-Making
Comparative Effectiveness Research
Decision Support Techniques
Evidence-Based Medicine
Abstract
This textbook introduces students to the basic concepts and methods used to measure and compare the expected benefits, risks and cost of preventive and therapeutic medical interventions. It provides an easily accessible overview of comparative effectiveness and its practical applications to daily medical decisions. The book includes learning objectives for each topic, definitions of key terms and topic summaries. Each chapter is written by a highly regarded academic and extensive reference is made throughout to other sources of literature where the interested reader can find further details. The book considers, among other topics, evidence based medicine and the role of comparative effectiveness research in the development of medical guidelines, bias and confounding, quality of life, randomized controlled trials, analyses of retrospective databases, screening and economic evaluation. The book is intended to serve as a "what is it?", "why do we need it?" and "how does it or could it effect positive change in health care?"" rather than just a "how to" technical overview. As such, it provides an essential resource for both under- and post-graduate students in health sciences.
Contents
1. Introduction to Comparative Effectiveness Research -- 2. Randomized Controlled Trials -- 3. Observational Studies -- 4. Evaluating Published CER Evidence -- 5. Epidemiological Principles Applied to CER -- 6. The Question of Value -- 7. Medical Decision Making: When Evidence and Medical Culture Clash -- 8. The Value of Prevention.
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e-Book
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Online
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Pharmacovigilance in Psychiatry

https://libcat.nshealth.ca/en/permalink/provcat39963
Edoardo Spina, Gianluca Trifir©ø, editors. (1st ed.) --Cham: Springer International Publishing : Imprint: Adis , c2016.
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The first authoritative textbook specifically addressing issues of the field, this book delivers a focused discussion on several themes in psychiatry while providing a sound background on pharmacovigilance. Internationally-recognised researchers, clinicians and pharmacovigilance experts contributed to this textbook, giving it the benefit of different perspectives and years of experience. Pharmacovigilance in psychiatry provides a thorough introduction to this field but goes on to explore advanc…
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Other Authors
Spina, Edoardo
Trifir©ø, Gianluca
Responsibility
Edoardo Spina, Gianluca Trifir©ø, editors
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Adis
Date of Publication
c2016
Physical Description
1 online resource (xi, 319 p. : 12 illus. in color)
ISBN
9783319247410
9783319247397 (print ed.)
Subjects (MeSH)
Mental Disorders - drug therapy
Pharmacovigilance
Psychotropic Drugs - adverse effects
Psychotropic Drugs - therapeutic use
Abstract
The first authoritative textbook specifically addressing issues of the field, this book delivers a focused discussion on several themes in psychiatry while providing a sound background on pharmacovigilance. Internationally-recognised researchers, clinicians and pharmacovigilance experts contributed to this textbook, giving it the benefit of different perspectives and years of experience. Pharmacovigilance in psychiatry provides a thorough introduction to this field but goes on to explore advanced themes such as methodologies and resources used for pharmacovigilance in psychiatry, challenges as well as most recent developments to this field, making it suitable for under-graduates, graduate and post-doctoral students and persons working pharmacovigilance who seek to broaden their knowledge on this subject.
Contents
Part I. General Aspects of Pharmacovigilance in Psychiatry -- 1. Pharmacovigilance in Psychiatry: An Introduction -- 2. Adverse Drug Reactions: Definitions, Classifications and Regulatory Aspects -- 3. Methods for the Post-Marketing Monitoring of Psychotropics Safety: Interests and Pitfalls -- 4. Contribution of UK Prescription-Based Event Monitoring Methods in the Pharmacovigilance of Psychotropic Medications -- 5. The Role of Healthcare Databases in Pharmacovigilance of Psychotropic Drugs -- 6. Monitoring of Plasma Concentrations of Psychotropic Drugs in Pharmacovigilance -- 7. The Role of Pharmacogenetics in Pharmacovigilance of Psychotropic Drugs -- Part II. Pharmacovigilance of Specific Psychotropic Drug Classes -- 8. Safety and Tolerability of Antidepressants -- 9. Safety and Tolerability of Antipsychotics -- 10. Safety and Tolerability of Anxiolytics/Sedative-Hypnotics -- 11. Safety and Tolerability of Mood Stabilisers -- 12. Safety and Tolerability of Medications for ADHD -- Part III. Pharmacovigilance of Psychotropic Drugs in Special Populations -- 13. Safety of Psychotropic Drugs in Children and Adolescents -- 14. Safety of Psychotropic Drugs in the Elderly -- 15. Safety of Psychotropic Drugs in Pregnancy and Breastfeeding.
Format
e-Book
Location
Online
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Recurrent Pregnancy Loss : Evidence-Based Evaluation, Diagnosis and Treatment

https://libcat.nshealth.ca/en/permalink/provcat40041
Asher Bashiri, Avi Harlev, Ashok Agarwal, editors. (1st ed.) --Cham: Springer , c2016.
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Providing the latest evidence-based information on etiology, evaluation and treatment, this unique text provides an in-depth, comprehensive discussion of the epidemiology, genetic and endocrinologic factors and medical and surgical management of recurrent pregnancy loss (RPL). Taking a multidisciplinary approach including psychological treatment and patient perspectives, all aspects of current RPL prevention and treatment are elucidated. Detailed chapters provide real-world illustrative materia…
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Other Authors
Bashiri, Asher
Harlev, Avi
Agarwal, Ashok
Responsibility
Asher Bashiri, Avi Harlev, Ashok Agarwal, editors
Edition
1st ed.
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xv, 208 p. : 26 illus., 2 illus. in color)
ISBN
9783319274522
9783319274508 (print ed.)
Subjects (MeSH)
Abortion, Habitual
Embryo Loss
Fetal Death
Abstract
Providing the latest evidence-based information on etiology, evaluation and treatment, this unique text provides an in-depth, comprehensive discussion of the epidemiology, genetic and endocrinologic factors and medical and surgical management of recurrent pregnancy loss (RPL). Taking a multidisciplinary approach including psychological treatment and patient perspectives, all aspects of current RPL prevention and treatment are elucidated. Detailed chapters provide real-world illustrative material and cover the set-up and management of RPL clinics and databases, containing practical tips. Recurrent Pregnancy Loss will be an excellent resource for OB-GYN specialists, general and reproductive endocrinologists, radiologists, hematologists, psychiatrists, psychologists, and any other investigators or clinicians treating patients confronted with this emotionally and physically trying condition.
Contents
Part I: Introduction to Recurrent Pregnancy Loss -- Recurrent pregnancy loss: definitions, epidemiology, and prognosis -- Implantation, physiology of placentation -- Part II: Causes of Recurrent Pregnancy Loss -- Endocrine abnormalities in RPL -- Genetics of recurrent pregnancy loss -- Inherited and acquired thrombophilias and adverse pregnancy outcomes -- Immunological causes of recurrent pregnancy loss -- Anatomical aspects in recurrent pregnancy loss -- Male factors in recurrent pregnancy loss -- Lifestyle and RPL -- The common characteristics between Infertility and recurrent pregnancy loss -- Part III: Management of Recurrent Pregnancy Loss -- Contemporary Prevention and treatment of recurrent pregnancy loss -- Part IV: Psychological and Supporting Aspects of Recurrent Pregnancy Loss -- The healthcare giver's perspective: The importance of emotional support for women with recurrent RPL -- A patient's perspective -- Part V: The Future -- New frontiers in RPL research and treatment.
Format
e-Book
Location
Online
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Adherence in Dermatology

https://libcat.nshealth.ca/en/permalink/provcat40182
Scott A. Davis, editor. --Cham: Springer International Publishing : Imprint: Adis , c2016.
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An essential, comprehensive, and practical guide to understanding, measuring, and modifying patients' adherence behavior to optimize treatment outcomes, this book covers all major aspects of adherence in dermatology. The first section describes current knowledge on the magnitude and impact of nonadherence; the second outlines measuring adherence in the context of databases, trials and practice. The third section addresses adherence in key skin diseases and the fourth covers numerous strategies …
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Other Authors
Davis, Scott A
Responsibility
Scott A. Davis, editor
Place of Publication
Cham
Publisher
Springer International Publishing : Imprint: Adis
Date of Publication
c2016
Physical Description
1 online resource (viii, 178 p. : 15 illus., 13 illus. in color)
ISBN
9783319309941
9783319309927 (print ed.)
Subjects (MeSH)
Directly Observed Therapy - methods
Patient Compliance
Physician-Patient Relations
Skin Diseases - therapy
Abstract
An essential, comprehensive, and practical guide to understanding, measuring, and modifying patients' adherence behavior to optimize treatment outcomes, this book covers all major aspects of adherence in dermatology. The first section describes current knowledge on the magnitude and impact of nonadherence; the second outlines measuring adherence in the context of databases, trials and practice. The third section addresses adherence in key skin diseases and the fourth covers numerous strategies to improve adherence by mitigating specific patient barriers. All sections emphasize ways to optimize communication with patients: the foundation for producing successful health behavior change. Low adherence helps explain why, despite effective treatments existing for all major dermatologic conditions, many patients still fail to improve. When clinicians endeavour to maximize adherence, with the aid of evidence-based strategies, these drugs will often realise their potential. This book devotes special attention to understanding why individuals may be nonadherent, so that each patient can receive a suitable treatment regimen, with a personalized plan of action. This book is designed for clinicians at all levels, serving as both introductory training for medical students and residents, and an update on the field for experienced practitioners. Researchers and policymakers will also benefit from its coverage of research methods and the impact of nonadherence in specific diseases. Adherence in Dermatology bridges the gap between outcomes researchers and clinicians by explaining the latest findings in plain language, with examples from everyday dermatologic practice.
Contents
Part I. What is known about adherence behavior -- 1. Impact of Non-Adherence in Dermatology -- 2. Models of Adherence -- 3. Impact of demographic and treatment-related factors -- 4. Non-attendance, predictors and interventions -- Part II. Methods of measuring adherence -- 5. Using Retrospective Databases to Study Adherence -- 6. Measuring Adherence in Clinical Trials -- 7. How providers can assess their patients' adherence in clinical settings -- Part III. Adherence in specific diseases -- 8. Topical application and variability of the de facto applied dose: technical aspects -- 9. Adherence in Acne -- 10. Psoriasis and adherence to therapy: individual, treatment-related and general factors -- 11. Adherence in atopic dermatitis -- 12. Adherence in Other Dermatologic Conditions -- Part IV. Strategies to improve adherence -- 13. Optimizing the Physician-Patient Relationship and Educating the Patient about Adherence -- 14. Choosing the treatment the patient is most likely to use -- 15. Dealing with forgetfulness -- 16. Building Motivation and Self-Efficacy.
Format
e-Book
Location
Online
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