Drug resistance in leishmania parasites : consequences, molecular mechanisms and possible treatments
https://libcat.nshealth.ca/en/permalink/provcat32519
Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves, editors.
--Vienna:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease…
- Available Online
- View e-Book
- Other Authors
- Ponte-Sucre, Alicia
- Diaz, Emilia
- Padrón-Nieves, Maritza
- Responsibility
- Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves, editors
- Place of Publication
- Vienna
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xiv, 459 p. : 44 ill., 24 ill. in color)
- ISBN
- 9783709111253
- Subjects (MeSH)
- Drug Resistance
- Leishmania - drug effects
- Leishmaniasis
- Subjects (LCSH)
- Vaccines
- Drug interactions
- Parasitology
- Pharmaceutical technology
- Infectious diseases
- Microbiology
- Abstract
- One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
- Contents
- Foreword -- Introduction. Leishmaniasis, the biology of a parasite. Alicia Ponte Sucre -- I Determinant features in leishmaniasis -- 1 Molecular evolution and phylogeny of Leishmania. Gabriele Schoenian, Elisa Cupolillo, Isabel Mauricio -- 2 The role of reservoirs: Canine leishmaniasis. Lenea Campino, Carla Maia -- 3 Epidemiology of leishmaniasis in the time of drug resistance. Jean Claude Dujardin, Saskya Decuypere -- II Leishmania and the immune system -- 4 The role of the immune system in resistance to infection. Lukasz Kedzierski, Krystal J. Evans -- 5 Vaccination as a control measure. Katrin Forber , Heidrun Moll -- 6 Leishmania vaccines: Past, Present and Future. Bhavana Sethu Lakshmi, Rentala Madhubala.- III Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance -- 7 Co-infection with HIV. Margriet den Boer, Luis Rivas, Jorge Alvar.- 8 Visceral leishmaniasis. Shyam Sundar , J aya Chakravarty -- 9 American Tegumentary leishmaniasis. Olga Zerpa, Alicia Ponte-Sucre -- IV Molecular features of drug-resistant Leishmania -- 10 Genetic expression and drug resistance, the role of proteomics. Patricia Cuervo, Jose Batista de Jesus.- 11 The role of ABC transporters in drug-resistant Leishmania. Adriano C Coelho, Paulo C Cotrim -- 12 Functional analysis of Leishmania membrane (non ABC) transporters involved in drug resistance. Scott M Landfear -- 13 Intracellular mechanisms of resistance in Leishmania -- V Pharmacology and chemotherapy of leishmaniasis. Mitali Chatterjee -- 14 Classical vs new Treatment regimens. Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos, Vanessa Yardley -- 15 Drug targets, drug effectors and drug targeting and delivery. Philippe M Loiseau, Gillian Barratt -- 16 Mechanisms of miltefosine resistance in Leishmania. Francisco Gamarro, Maria P Sanchez-Cacete, Santiago Castanys -- 17 P-glycoprotein-like transporters in Leishmania: a search for reversal agents. Bruno Pradines.- VI Strategies to circumvent drug resistance in Leishmania -- 18 The relevance of susceptibility tests, breakpoints and markers. Louis Maes, Paul Cos and Simon Croft -- 19 The Concept of Fitness and drug resistance in Leishmania. Alicia Ponte-Sucre, Emilia Diaz, Maritza Padron-Nieves.
- Format
- e-Book
- Location
- Online
Extraskeletal Effects of Vitamin D : A Clinical Guide
https://libcat.nshealth.ca/en/permalink/provcat42872
Emilia Pauline Liao, editor.
--Cham:
Humana Press
, c2018.
- Available Online
- View e-Book
- Location
- Online
While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the bioche…
- Available Online
- View e-Book
- Other Authors
- Liao, Emilia Pauline
- Responsibility
- Emilia Pauline Liao, editor
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xiii, 254 p.) : 24 illus., 17 illus. in color
- Series Title
- Contemporary endocrinology
- ISBN
- 9783319737423
- 9783319737416 (print ed.)
- 9783319737430 (print ed.)
- ISSN
- 2523-3785
- Subjects (MeSH)
- Vitamin D Deficiency - physiopathology
- Vitamin D - physiology
- Specialty
- Nutritional Sciences
- Abstract
- While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function. Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.
- Contents
- 1. Vitamin D Biochemistry and Physiology -- 2. Vitamin D and Autoimmune Diseases -- 3. Vitamin D and Infectious Diseases -- 4. Vitamin D Hormone Action in the Endocrine Tissue: Implications for Prostate and Breast Carcinoma -- 5. Vitamin D and Colorectal Cancer -- 6. Vitamin D and Leukaemia -- Vitamin D and Diabetes -- 8. Vitamin D and Cardiovascular Disease -- 9. Vitamin D and Obesity -- 10. Vitamin D in Male and Female Reproduction 11. Muscle Weakness and Falls -- 12. Vitamin D and the Central Nervous System: Development, Protection, and Disease.
- Format
- e-Book
- Location
- Online
Dermatology and Diabetes
https://libcat.nshealth.ca/en/permalink/provcat43343
Emilia Noemí Cohen Sabban, Félix Miguel Puchulu, Kenneth Cusi, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book reviews the dermatological manifestations of Diabetes Mellitus, including a broad spectrum of conditions since the dysfunction of the cutaneous barrier, going through cutaneous infections in diabetics, dermatoses associated to Diabetes and manifestations related to Diabetes treatment. Moreover, the book comprises the latest concepts regarding epidemiology, classification, diagnosis and treatment of Diabetes Mellitus, insulin resistance and metabolic syndrome, including useful tools fo…
- Available Online
- View e-Book
- Other Authors
- Cohen Sabban, Emilia Noemí
- Puchulu, Félix Miguel
- Cusi, Kenneth
- Responsibility
- Emilia Noemí Cohen Sabban, Félix Miguel Puchulu, Kenneth Cusi, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (viii, 305 p.) : 168 illus., 165 illus. in color
- ISBN
- 9783319724751
- 9783319724744 (print ed.)
- 9783319724768 (print ed.)
- Subjects (MeSH)
- Diabetes Complications
- Diabetes Mellitus - physiopathology
- Skin Diseases
- Skin Manifestations
- Specialty
- Dermatology
- Diabetes Mellitus
- Abstract
- This book reviews the dermatological manifestations of Diabetes Mellitus, including a broad spectrum of conditions since the dysfunction of the cutaneous barrier, going through cutaneous infections in diabetics, dermatoses associated to Diabetes and manifestations related to Diabetes treatment. Moreover, the book comprises the latest concepts regarding epidemiology, classification, diagnosis and treatment of Diabetes Mellitus, insulin resistance and metabolic syndrome, including useful tools for the management of patients with diabetes. It explains why skin conditions have such a great impact on the quality of life of these patients, particularly the subset of patients with diabetic foot syndrome. Dermatology and Diabetes discusses all these dermatologic conditions and provides a roundup of the current guidelines in diabetic patients. Taking into account the critical differential diagnostic information and therapeutic options, the book is an important reference for clinical dermatologist and all health care professionals involved.
- Contents
- 1. Epidemiology of Diabetes -- 2. Definition, Diagnosis and Classification of Diabetes Mellitus -- 3. Basic Concepts in Insulin Resistance and Diabetes Treatment -- 4. Introduction to Cutaneous Manifestations of Diabetes Mellitus -- 5. Cutaneous Barrier, Innate Immunity and Diabetes -- 6. Cutaneous Markers of Diabetes Mellitus -- 7. Thick Skin Syndrome -- 8. Insulin Resistance and Acanthosis Nigricans -- 9. Fungal Infections in Diabetics -- 10. Diagnosis and Treatment of Infectious Complications at Diabetic Foot -- 11. Dermatoses Most Frequently Related to Diabetes Mellitus -- 12. Cutaneous Manifestations Induced by Antidiabetic Treatment -- 13. Multidisciplinary Management of Wound Healing in Diabetics -- 14. Vascular and Neuropathic Foot -- 15. Diabetes, Non-Enzymatic Glycation, and Aging -- 16. Nail Disorders in Diabetics.
- Format
- e-Book
- Location
- Online
Hidden and Lesser-known Disordered Eating Behaviors in Medical and Psychiatric Conditions
https://libcat.nshealth.ca/en/permalink/provcat47134
Emilia Manzato, Massimo Cuzzolaro, Lorenzo Maria Donini.
Springer
, 2022.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Responsibility
- Emilia Manzato, Massimo Cuzzolaro, Lorenzo Maria Donini
- Publisher
- Springer
- Date of Publication
- 2022
- Physical Description
- 1 online resource (xi, 386 pages) : illustrations
- ISBN
- 9783030811747
- Specialty
- Psychiatry
- Format
- e-Book
- Location
- Online
