This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and ch…
This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet co…
This book provides a comprehensive overview of current arthroscopic techniques for the management of ankle joint disorders. An introductory section clearly and accessibly explains the anatomy in question, the portal placement and other ankle procedures, addressing both the articular and extra-articular compartments. All currently available minimally invasive surgical options and the management of various upper and lower lesions of the ankle are then described step by step, discussing the main i…
This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including fr…
This superbly illustrated atlas provides step-by-step descriptions of surgical procedures to the airways based on use of the sheep as an animal model, which has been demonstrated scientifically to be comparable to the human. The procedures covered--tracheotomy, laryngotracheoplasty, slide tracheoplasty, tracheal reconstruction, partial cricotracheal reconstruction, and main endoscopic techniques--are relevant to a range of frequent surgical indications, such as stenosis, laryngotracheomalacia, …
This atlas documents current surgical approaches to the craniocervical junction and the cervical spine, providing step-by-step guidance on procedures and cervical spine stabilization techniques. Opening chapters present essential information on anatomy, depict pathologies with the aid of illustrative cases, describe the role of imaging techniques in patient evaluation, and discuss surgical instrumentation and patient positioning. The different techniques employed in this delicate anatomic regio…
This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technic…
This atlas provides a detailed visual resource of how sophisticated non-invasive imaging relates to the anatomy observed in a variety of cardiovascular pathologies. It includes investigation of a wide range of defects in numerous cardiac structures. Mitral valve commissures, atrioventricular septal junction and right ventricular outflow tract plus a wealth of other structures are covered, offering readers a comprehensive integrative experience to understand how anatomic subtleties are revealed …
This atlas, containing a wealth of clinical and dermoscopic images, describes and illustrates the applications of dermoscopy in a wide variety of skin disorders that may be encountered in the pediatric population. Key features and other salient aspects are highlighted with the aim of enabling the clinician to reach a fast and reliable diagnosis in all cases. Dermoscopy is a non-invasive technique that allows rapid and magnified in vivo observation of the skin, with visualization of morphologic …
Diagnosis of benign tumors of the liver is experiencing exponential growth, mainly owing to the diffusion of more accurate imaging techniques. This monograph opens by examining the epidemiology, histopathology, and genetics of these diseases and discussing liver physiopathology. The role of imaging techniques is described, and clear guidance provided on differential diagnosis. The full range of benign liver tumors and conditions is then systematically reviewed, including liver cysts and polycys…
Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing ONJ are much higher for cancer patients on intravenous bisphosphonate therapy (used to reduce bone pain), the occurrence of ONJ also in patients treated…
This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory,…
This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomi…
This book discusses canine and feline skin cytology and the importance of this diagnostic tool in interpreting skin lesions. With more than 600 clinical and cytological color pictures, it explains the cytological patterns observed in all cutaneous inflammatory and neoplastic lesions in cats and dogs, as well as cutaneous metastasis of non-primary skin neoplasms. The first part of the book describes cell morphology and cytological patterns, providing an overview of the normal structure of the sk…
Diabetic retinopathy (DR) and its dramatic and sight-threatening complications, such as diabetic macular edema, remain a leading cause of visual impairment among the working-age population. With the advent of effective treatments, a new era in the management of DR has been opened up: it is now possible for patients to regain a degree of visual acuity not previously expected. However, amid the deluge of approved treatments and promising new strategies, clinicians may find it difficult to choose …