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Acute Promyelocytic Leukemia : A Clinical Guide

https://libcat.nshealth.ca/en/permalink/provcat42873
edited by Oussama Abla, Francesco Lo Coco, Miguel A. Sanz. --Cham: Springer , c2018.
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This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and ch…
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Other Authors
Abla, Oussama
Lo Coco, Francesco
Sanz, Miguel A.
Responsibility
edited by Oussama Abla, Francesco Lo Coco, Miguel A. Sanz
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 274 p.) : 39 illus., 29 illus. in color
ISBN
9783319642574
9783319642567 (print ed.)
9783319642581 (print ed.)
9783030097134 (print ed.)
Subjects (MeSH)
Leukemia, Promyelocytic, Acute
Specialty
Hematology
Medical Oncology
Abstract
This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges. Written by top experts in the field,áAcute Promyelocytic Leukemia: A Clinical Guideáis a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.
Contents
History of APL -- Molecular Targets of Treatment in APL -- The Leukemic Stem Cell -- The Molecular Genetics of APL -- APL Coagulopathy -- Early Death in APL -- Prognostic Factors in APL -- First-line therapy for APL: Chemotherapy-based approach -- First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach -- Cure of APL without Chemotherapy -- Minimal Residual Disease in APL -- Treatment of refractory and relapsed APL -- Hematopoietic Stem Cell Transplantation in APL -- APL in Children -- Management of APL in the Elderly -- Special Situations in APL -- APL in Developing Countries: A Chemotherapy-Based Approach -- APL in Developing Countries: ATO based Approach -- Therapy-Related APL -- Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes -- Management of Treatment-Related Complications in APL.
Format
e-Book
Location
Online
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Advanced Imaging Techniques in Clinical Pathology

https://libcat.nshealth.ca/en/permalink/provcat39722
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors. --New York, NY: Springer New York : Imprint: Humana Press , c2016.
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This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet co…
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Sacerdoti, Francesco M
Giordano, Antonio
Cavaliere, Carlo
Responsibility
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date of Publication
c2016
Physical Description
1 online resource (ix, 165 p. : 53 illus., 37 illus. in color)
Series Title
Current clinical pathology
ISBN
9781493934690
9781493934676 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Clinical Laboratory Techniques
Diagnostic Imaging
Pathology, Clinical - methods
Abstract
This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. Advanced Imaging Techniques in Clinical Pathology will be of great value to clinical pathologists, biologists, biology researchers, and those working in the clinical and biological laboratory arena.
Contents
1 Introduction -- Part I. Basic Knowledge -- 2 Digital Image Processing -- 3 Statistical Analysis and Software -- Part II. Applications -- 4 Microscopy Techniques -- 5 Cytometry and Pathology -- 6 Advanced Imaging Techniques -- Part III. Diagnostic Imaging and Pathology -- 7 Diagnostic Imaging and Pathology -- 8 Preclinical Techniques in Animals -- 9 Preclinical Imaging: Experimental Example -- 10 Clinical Techniques in Humans -- 11 Clinical Imaging Experimental Example in Pathology -- 12 Ultrasound in the Evaluation of Cutaneous Diseases -- 13 Diagnostic Imaging Techniques: Lessons Learned -- Erratum to: Advanced Imaging Techniques in Clinical Pathology.
Format
e-Book
Location
Online
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Anal Fistula and Abscess

https://libcat.nshealth.ca/en/permalink/provcat47154
Carlo Ratto, Angelo Parello, Francesco Litta, Veronica De Simone, Paola Campennì [editors]. --Cham: Springer , 2020.
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Online
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Other Authors
Ratto, Carlo
Parello, Angelo
Litta, Francesco
De Simone, Veronica
Campennì, Paola
Responsibility
Carlo Ratto, Angelo Parello, Francesco Litta, Veronica De Simone, Paola Campennì [editors]
Place of Publication
Cham
Publisher
Springer
Date of Publication
2020
Physical Description
1 online resource (x, 390 pages)
Series Title
Coloproctology
ISBN
9783030309022
Specialty
Colorectal Surgery
Notes
"Living reference work."
Format
e-Book
Location
Online
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Ankle Joint Arthroscopy : A Step-by-Step Guide

https://libcat.nshealth.ca/en/permalink/provcat45505
Francesco Allegra, Fabrizio Cortese, Francesco Lijoi, editors. --Cham: Springer , c2020.
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This book provides a comprehensive overview of current arthroscopic techniques for the management of ankle joint disorders. An introductory section clearly and accessibly explains the anatomy in question, the portal placement and other ankle procedures, addressing both the articular and extra-articular compartments. All currently available minimally invasive surgical options and the management of various upper and lower lesions of the ankle are then described step by step, discussing the main i…
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Other Authors
Allegra, Francesco
Cortese, Fabrizio
Lijoi, Francesco
Responsibility
Francesco Allegra, Fabrizio Cortese, Francesco Lijoi, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xiv, 269 p.) : 187 illus., 163 illus. in color
ISBN
9783030292317
9783030292300 (Print ed.)
9783030292324 (Print ed.)
9783030292331 (Print ed.)
Subjects (MeSH)
Ankle Joint - surgery
Arthroscopy - methods
Specialty
Orthopedic Procedures
Abstract
This book provides a comprehensive overview of current arthroscopic techniques for the management of ankle joint disorders. An introductory section clearly and accessibly explains the anatomy in question, the portal placement and other ankle procedures, addressing both the articular and extra-articular compartments. All currently available minimally invasive surgical options and the management of various upper and lower lesions of the ankle are then described step by step, discussing the main issues concerning each of them and sharing useful tips and tricks. A closing chapter is devoted to rehabilitation, which greatly differs in patients treated with arthroscopic procedures and those undergoing open surgery. The volume is also supplemented by detailed videos for each technique and procedure, both outside on the cutaneous layer and inside the joint. The book offers an invaluable tool for orthopedic surgeons and fellows dealing with foot and ankle disorders who normally prefer to use open procedures and desire to complement their surgical options with arthroscopy, as well as for those surgeons already familiar with arthroscopic techniques who would like to broaden their knowledge of the field.
Contents
Part I. Anatomy of Ankle Joint -- 1. Gross Anatomy of Ankle Joint and Hindfoot -- 2. Gross Anatomy of Subtalar Joint -- Part II. Basic Ankle Arthroscopy -- 3. Instrumentation and Operative Setup for Anterior Ankle, Posterior Ankle and Subtalar Arthroscopy -- 4. Diagnostic Arthroscopy for Anterior/Posterior Ankle Joint -- Part III. Impingement of Anterior/Posterior Ankle and Subtalar Joint -- 5. Bony Impingement: Etiology and Classifications, Treatment, Arthroscopic Procedures -- 6. Soft Tissue Impingement: Etiology and Classifications, Treatment, Arthroscopic Procedures -- Part IV. Chondral and Osteochondral Ankle Joint Defects -- 7. Etiology, Classifications, Mechanism of Action -- 8. Repair by Microfractures and Perforations -- 9. Restore by OAT -- 10. Restore by ACI /MACI Procedure -- 11. Repair by ACIC Technique -- 12. Restore by Mesenchimal Cells -- 13. The Use of Allograft -- Part V. Instability of Ankle and Subtalar Joint -- 14. Ankle Sprains: Classification, Treatment and Arthroscopic Procedures -- 15. Instability of Ankle and Subtalar Joint -- 16. Arthroscopic Broström Procedure -- 17. Capsular Plication Repair -- 18. Radiofrequency Repair -- 19. Ligaments Anatomic Repair -- 20. Syndesmotic Joint Instability Arthroscopic Repair -- Part VI. Upper and Lower Ankle Arthritis -- 21. Ankle Arthritis: Etiology and Classifications -- 22. Ankle Joint Debridement -- 23. Ankle Fusion by Screws -- 24. Ankle Fusion by Nail -- 25. Subtalar Joint Arthritis: Treatment and Arthroscopic Lateral Procedures -- 26. Arthroscopic Subtalar Arthrodesis by Posterior Approach -- Part VII. Ankle Tendinopathies -- 27. Flexor Hallucis Longus Tendinopathy -- 28. Peroneal Tendons Tendinopathy -- 29. Tibialis Posterior Tendinopathy -- 30. Haglund Disease -- 31. Achilles’ Tendon Tendinopathies -- Part VIII. Plantar Fascia -- 32. Endoscopic Treatment of Plantar Fascitis -- Part IX. Great Toe Disorders -- 33. Etiology, Classifications and Treatment by Arthroscopic Procedures -- Part X. Rehabilitation -- 34. Rehabilitation Following Ankle Arthroscopy.
Format
e-Book
Location
Online
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Antioxidants in Andrology

https://libcat.nshealth.ca/en/permalink/provcat41396
Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco, editors Lombardo, editors. --Cham: Springer , 2017.
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This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including fr…
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Balercia, Giancarlo
Gandini, Loredana
Lenzi, Andrea
Lombardo, Francesco
Other Authors
Società Italiana di Andrologia e Medicina della Sessualità
Responsibility
Giancarlo Balercia, Loredana Gandini, Andrea Lenzi, Francesco, editors Lombardo, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (vii, 79 pages) : 7 illus. in color
Series Title
Trends in andrology and sexual medicine
ISBN
9783319417493
9783319417479 (print ed.)
ISSN
2367-0088
Subjects (MeSH)
Andrology
Antioxidants - pharmacology
Antioxidants - therapeutic use
Genital Diseases, Male - drug therapy
Infertility, Male - drug therapy
Oxidative Stress - physiology
Sexual Dysfunction, Physiological - drug therapy
Carnitine - physiology
Ubiquinone - analogs & derivatives
Abstract
This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including free radicals, exceeds the body's natural antioxidant defences, leading to cellular damage. Oxidative stress is present in about half of all infertile men, and reactive oxygen species can produce infertility both by damaging the sperm membrane, with consequences for sperm motility, and by altering the sperm DNA. There is consequently a clear rationale for the use of antioxidant treatments within andrology, and various in vitro and in vivo studies have indicated that many antioxidants indeed have beneficial impacts. In providing a detailed and up-to-date overview of the subject, this book will be of interest to both practitioners and researchers in andrology, endocrinology, and urology.
Contents
1. Free Radicals in Andrology -- 2. Biochemistry of Coenzyme Q10 -- 3. Carnitine in Male Infertility -- 4. Coenzyme Q10 in Male Infertility -- 5. Antioxidants in Male Accessory Gland Infection -- 6. Antioxidants in Male Sexual Dysfunctions.
Format
e-Book
Location
Online
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Atlas of Airway Surgery : A Step-by-Step Guide Using an Animal Model

https://libcat.nshealth.ca/en/permalink/provcat41629
Angelo Ghidini, Francesco Mattioli, Sergio Bottero, Livio Presutti, editors. --Cham: Springer , 2017.
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This superbly illustrated atlas provides step-by-step descriptions of surgical procedures to the airways based on use of the sheep as an animal model, which has been demonstrated scientifically to be comparable to the human. The procedures covered--tracheotomy, laryngotracheoplasty, slide tracheoplasty, tracheal reconstruction, partial cricotracheal reconstruction, and main endoscopic techniques--are relevant to a range of frequent surgical indications, such as stenosis, laryngotracheomalacia, …
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Ghidini, Angelo
Mattioli, Francesco
Bottero, Sergio
Presutti, Livio
Responsibility
Angelo Ghidini, Francesco Mattioli, Sergio Bottero, Livio Presutti, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (vii, 123 pages) : 185 illus. in color
ISBN
9783319497396
9783319497389 (print ed.)
Subjects (MeSH)
Models, Animal
Respiratory System - surgery
Surgical Procedures, Operative - methods
Abstract
This superbly illustrated atlas provides step-by-step descriptions of surgical procedures to the airways based on use of the sheep as an animal model, which has been demonstrated scientifically to be comparable to the human. The procedures covered--tracheotomy, laryngotracheoplasty, slide tracheoplasty, tracheal reconstruction, partial cricotracheal reconstruction, and main endoscopic techniques--are relevant to a range of frequent surgical indications, such as stenosis, laryngotracheomalacia, and tracheal tumor. The book is the first to describe such surgery on the basis of this animal model and includes a full description of preparation of the model. The practical guidance provided will equip surgical trainees with the knowledge required before embarking on these procedures in humans, but will also be highly relevant to more experienced surgeons wishing to upgrade their skills. The book is the outcome of a successful collaboration between the Head and Neck Surgery Departments of the University Hospital of Modena and the Bambino Gesù Hospital in Rome.
Contents
1. Anatomy of Animal Model and Comparison to Human -- 2. How to Prepare an Animal Model -- 3. Tracheotomy -- 4. Laryngotracheoplasty (Anterior and Posterior Cricoid Split) -- 5. Slide Tracheoplasty -- 6. Step-by-Step Tracheal Resection with End-to-End Anastomosis -- 7. Step-by-Step Partial Cricotracheal Resection (PCTR) -- 8. Larynx Box -- 9. Endoscopic Procedures.
Format
e-Book
Publication Type
Atlas
Location
Online
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Atlas of Craniocervical Junction and Cervical Spine Surgery

https://libcat.nshealth.ca/en/permalink/provcat41435
Stefano Boriani, Livio Presutti, Alessandro Gasbarrini, Francesco Mattioli, editors. --Cham: Springer , 2017.
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This atlas documents current surgical approaches to the craniocervical junction and the cervical spine, providing step-by-step guidance on procedures and cervical spine stabilization techniques. Opening chapters present essential information on anatomy, depict pathologies with the aid of illustrative cases, describe the role of imaging techniques in patient evaluation, and discuss surgical instrumentation and patient positioning. The different techniques employed in this delicate anatomic regio…
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Other Authors
Boriani, Stefano
Presutti, Livio
Gasbarrini, Alessandro
Mattioli, Francesco
Responsibility
Stefano Boriani, Livio Presutti, Alessandro Gasbarrini, Francesco Mattioli, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (x, 227 pages) : 26 illus., 10 illus. in color
ISBN
9783319427379
9783319427355 (print ed.)
Subjects (MeSH)
Cervical Vertebrae - surgery
Abstract
This atlas documents current surgical approaches to the craniocervical junction and the cervical spine, providing step-by-step guidance on procedures and cervical spine stabilization techniques. Opening chapters present essential information on anatomy, depict pathologies with the aid of illustrative cases, describe the role of imaging techniques in patient evaluation, and discuss surgical instrumentation and patient positioning. The different techniques employed in this delicate anatomic region, including transnasal and transoral endoscopic approaches to the craniocervical junction and posterior and anterior approaches to the cervical spine, are then explained and illustrated with a view to providing the surgeon with a clear reference that can be used in the operating room. In addition, practical advice is offered on the treatment of potential complications, postoperative management, and rehabilitation. This book will be of value not only to neurosurgeons but also to orthopedists, ENT surgeons, neurologists, and physiatrists.
Contents
Part I: Anatomy -- 1. Anatomy of Craniocervical Junction -- 2. Anatomy of the Subaxial Cervical Spine -- 3. Anatomy of the Neck -- Part II: Planning -- 4. Interventional Radiology: Presurgical Selective Angiographic Embolization (SAE) in Hypervascular Cervical Spine Tumours -- 5. Anesthesiological Management and Patient Positioning -- 6. Cervical Spine Instrumentation -- 7. Tracheotomy Surgical Technique -- 8. Surgical Planning in Cervical Spine Oncologic Patients -- Part III: Surgical Approaches -- 9. Surgical Approaches to CCJ (Endoscopic Transnasal-Transoral-Transcervical and Robotic Transoral Approach) -- 10. Anterior and Lateral Approaches to Cervical Spine -- 11. Posterior Approach to Cervical Spine -- 12. Exemplificative Cases in Cervical Spine -- 13. Complications of Cervical Spine Surgery.
Format
e-Book
Publication Type
Atlas
Location
Online
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Atlas of Human Semen Examination

https://libcat.nshealth.ca/en/permalink/provcat45615
Donatella Paoli, Francesco Lombardo, Andrea Lenzi. --Cham: Springer , c2020.
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This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technic…
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Author
Paoli, Donatella
Other Authors
Lombardo, Francesco
Lenzi, Andrea
Responsibility
Donatella Paoli, Francesco Lombardo, Andrea Lenzi
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (vii, 106 p.) : 172 illus. in color
Series Title
Trends in andrology and sexual medicine
ISBN
9783030399986
9783030399979 (Print ed.)
9783030399993 (Print ed.)
9783030400002 (Print ed.)
ISSN
2367-0088
Subjects (MeSH)
Cytodiagnosis
Cytological Techniques
Microscopy - methods
Spermatozoa - ultrastructure
Specialty
Men's Health
Microscopy
Reproductive Medicine
Abstract
This atlas provides valuable information on crucial aspects of sperm examination as well numerous meaningful color illustrations. It discusses successful evaluation of the sperm morphology and the cellular elements other than spermatozoa, enabling readers to unambiguously interpret seminal cytologic images and compare reports for diagnostic, therapeutic and prognostic purposes. With its extensive collection of colored images, the book is intended as a reference resource for students and technicians in the field of andrology as well as practitioners and clinicians in andrology, urology, pathology, IVF and other ART programs.
Contents
Introduction -- Human Semen Examination -- 1. Notes on Human Spermatogenesis -- 2. Morphological Structure of the Spermatozoon -- 3. Non-sperm Cellular Components of the Seminal Fluid -- 3.1 Elements from the Spermatogenesis Process -- 4. Morphological Study of the Seminal Fluid -- 4.1 Preparation of Semen Smears -- 4.2 Staining Techniques -- 5. Chromatin Aspect -- 5.1 Chromatin Organization in Human Sperm -- Further Reading -- Image Gallery: Sperm Morphology -- Image Gallery: Non-Sperm Cellular Components -- Image Gallery: Chromatin Integrity -- Image Gallery: Morphological Evaluation of Sperm Heads with Fragmented DNA, Using Both Transmitted (Bright Field) and Reflected (Dark Field) Light; Every Picture is Shown in Three Different Light Condition.
Format
e-Book
Publication Type
Atlas
Location
Online
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Atlas of Non-Invasive Imaging in Cardiac Anatomy

https://libcat.nshealth.ca/en/permalink/provcat44851
Francesco F. Faletra, Jagat Narula, Siew Yen Ho, editors. --Cham: Springer , c2020.
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This atlas provides a detailed visual resource of how sophisticated non-invasive imaging relates to the anatomy observed in a variety of cardiovascular pathologies. It includes investigation of a wide range of defects in numerous cardiac structures. Mitral valve commissures, atrioventricular septal junction and right ventricular outflow tract plus a wealth of other structures are covered, offering readers a comprehensive integrative experience to understand how anatomic subtleties are revealed …
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Other Authors
Faletra, Francesco F.
Narula, Jagat
Ho, Siew Yen
Responsibility
Francesco F. Faletra, Jagat Narula, Siew Yen Ho, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xi, 133 p.) : 9 illus.
ISBN
9783030355067
9783030355050 (Print ed.)
9783030355074 (Print ed.)
9783030355081 (Print ed.)
Subjects (MeSH)
Heart - anatomy & histology
Heart - diagnostic imaging
Specialty
Cardiology
Diagnostic Imaging
Abstract
This atlas provides a detailed visual resource of how sophisticated non-invasive imaging relates to the anatomy observed in a variety of cardiovascular pathologies. It includes investigation of a wide range of defects in numerous cardiac structures. Mitral valve commissures, atrioventricular septal junction and right ventricular outflow tract plus a wealth of other structures are covered, offering readers a comprehensive integrative experience to understand how anatomic subtleties are revealed by modern imaging modalities. Atlas of Non-Invasive Imaging in Cardiac Anatomy provides a detailed set of visual instructions that is of use to any cardiovascular professional needing to understand the orientation of a patient’s imaging. Therefore this is an essential guide for all trainee and practicing cardiologists, cardiac imagers, cardiac surgeons and interventionists.
Contents
The Mitral Valve -- The Aortic Root -- The Tricuspid Valve -- The Interatrial Septum, Septal Atrio-ventricular Junction, and Membranous Septum -- The Right and the Left Atrium -- The Left and Right Ventricles -- The Coronary Arteries and Veins.
Format
e-Book
Publication Type
Atlas
Location
Online
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Atlas of Pediatric Dermatoscopy

https://libcat.nshealth.ca/en/permalink/provcat42819
Giuseppe Micali, Francesco Lacarrubba, Giuseppe Stinco, Giuseppe Argenziano, Iria Neri, editors. --Cham: Springer , c2018.
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Online
This atlas, containing a wealth of clinical and dermoscopic images, describes and illustrates the applications of dermoscopy in a wide variety of skin disorders that may be encountered in the pediatric population. Key features and other salient aspects are highlighted with the aim of enabling the clinician to reach a fast and reliable diagnosis in all cases. Dermoscopy is a non-invasive technique that allows rapid and magnified in vivo observation of the skin, with visualization of morphologic …
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Other Authors
Micali, Giuseppe
Lacarrubba, Francesco
Stinco, Giuseppe
Argenziano, Giuseppe
Neri, Iria
Responsibility
Giuseppe Micali, Francesco Lacarrubba, Giuseppe Stinco, Giuseppe Argenziano, Iria Neri, editors
Alternate Title
Atlas of pediatric dermoscopy
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 260 p.) : 182 illus. in color
ISBN
9783319711683
9783319711676 (print ed.)
9783319711690 (print ed.)
Subjects (MeSH)
Child
Dermoscopy
Skin Diseases - diagnosis
Skin Diseases - pathology
Specialty
Dermatology
Pediatrics
Abstract
This atlas, containing a wealth of clinical and dermoscopic images, describes and illustrates the applications of dermoscopy in a wide variety of skin disorders that may be encountered in the pediatric population. Key features and other salient aspects are highlighted with the aim of enabling the clinician to reach a fast and reliable diagnosis in all cases. Dermoscopy is a non-invasive technique that allows rapid and magnified in vivo observation of the skin, with visualization of morphologic features imperceptible to the naked eye. Dermoscopy has revolutionized the approach to pigmented skin lesions, greatly improving diagnostic accuracy. Furthermore, over the past few years it has been demonstrated to be very useful in the diagnosis, follow-up, and therapeutic monitoring of a range of other skin disorders, including cutaneous/mucosal infections, ectoparasitoses, inflammatory diseases, and hair and nail abnormalities. Being non-invasive, dermoscopy is particularly suitable for use in the pediatric population, in which invasive diagnostic procedures may be problematic.
Format
e-Book
Publication Type
Atlas
Location
Online
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Atlas of Real Time 3D Transesophageal Echocardiography

https://libcat.nshealth.ca/en/permalink/provcat30093
by Francesco F. Faletra, Stefano Castro, Natesa G. Pandian, Itzhak Kronzon, Hans-Joachim Nesser, Siew Yen Ho. --London: Springer-Verlag , c2010.
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Location
Online
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Author
Faletra, Francesco F
Other Authors
Castro, Stefano
Pandian, Natesa G
Kronzon, Itzhak
Nesser, Hans-Joachim
Yen Ho, Siew
Responsibility
by Francesco F. Faletra, Stefano Castro, Natesa G. Pandian, Itzhak Kronzon, Hans-Joachim Nesser, Siew Yen Ho
Place of Publication
London
Publisher
Springer-Verlag
Date of Publication
c2010
ISBN
9781849960830
Subjects (MeSH)
Echocardiography, Transesophageal - Atlases
Echocardiography, Three-Dimensional - Atlases
Subjects (LCSH)
Diagnosis Ultrasonic
Cardiology
Format
e-Book
Location
Online
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Benign Tumors of the Liver

https://libcat.nshealth.ca/en/permalink/provcat39151
Luca Aldrighetti, Francesco Cetta, Gianfranco Ferla, editors. --Cham: Springer , c2015.
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Diagnosis of benign tumors of the liver is experiencing exponential growth, mainly owing to the diffusion of more accurate imaging techniques. This monograph opens by examining the epidemiology, histopathology, and genetics of these diseases and discussing liver physiopathology. The role of imaging techniques is described, and clear guidance provided on differential diagnosis. The full range of benign liver tumors and conditions is then systematically reviewed, including liver cysts and polycys…
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Other Authors
Aldrighetti, Luca
Cetta, Francesco
Ferla, Gianfranco
Responsibility
Luca Aldrighetti, Francesco Cetta, Gianfranco Ferla, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xvi, 337 p. : 110 illus., 57 illus. in color)
ISBN
9783319129853
9783319129846 (print ed.)
Subjects (MeSH)
Liver Neoplasms - diagnosis
Liver Neoplasms - therapy
Liver - physiopathology
Abstract
Diagnosis of benign tumors of the liver is experiencing exponential growth, mainly owing to the diffusion of more accurate imaging techniques. This monograph opens by examining the epidemiology, histopathology, and genetics of these diseases and discussing liver physiopathology. The role of imaging techniques is described, and clear guidance provided on differential diagnosis. The full range of benign liver tumors and conditions is then systematically reviewed, including liver cysts and polycystic liver disease, Caroli disease, hemangiomas, focal nodular hyperplasia, adenomas, hepatic manifestations of systemic diseases, and focal infectious diseases. Surgical indications are accurately analyzed, with a view to assisting in the avoidance of useless interventions. Transplantation, laparoscopic resection, and robotic surgical techniques are described and illustrated, emphasizing the optimization of intra- and postoperative management in order to avoid potential complications and degeneration. In these chapters, attention is drawn to the ways in which the surgical management of benign liver tumors differs from that of malignant tumors. Information is also provided on anesthesia, blood transfusion, the role of interventional radiology in patients with benign liver tumors and fast track programs for liver surgery. This book, in handy format, will prove essential reading for all who are interested in benign liver surgery and will represent an invaluable source of knowledge for general and hepatobiliary surgeons, whether in training or practice.
Contents
Foreword -- Preface -- Part I: General Perspective -- 1. Epidemiology and Histopathology of Benign Liver Tumors -- 2. Molecular Biology and Genetics of Benign Liver Tumors -- 3. Genetic Syndromes and Benign Liver Tumors (Multiple Adenomas in Glycogen Storage Disease) -- 4. Liver Physiopathology (Ischemia/Reperfusion, Factors affecting Liver Regeneration) -- Part II: Imaging -- 5. Imaging Techniques (Ultrasound, CT, MR) of Benign Liver Tumors -- 6. Imaging Morphology in Benign Liver Tumors -- 7. Differential Diagnosis of Benign Liver Tumors -- Part III: Systematic Review of Benign Liver Tumors -- 8. Cysts and Polycystic Liver Disease -- 9. Caroli's Disease: Cystic Bile Duct Dilatations -- 10.Hepatolithiasis -- 11. Hemangiomas -- 12. Focal Nodular Hyperplasia -- 13. Hepatocellular Adenoma -- 14. Adenoma and Biliary Cystadenoma -- 15.Benign Tumors of Bile Ducts and Gallbladder -- 16. Liver Focal Localizations of Systemic Diseases -- 17. Focal Infectious Diseases -- Part IV: Treatment of Benign Liver Tumors -- 18. Transplantation for Benign Liver Lesions -- 19. Laparoscopic Liver Surgery in Benign Liver Lesions -- 20. Robotic Liver Resection for Benign Tumors -- 21. Interventional Radiology in Benign Liver Tumors: Embolization and Ablation -- 22. Intraoperative Ultrasound in Liver Surgery for Benign Tumors -- 23. Anesthesia and Intraoperative Management in Liver Surgery -- 24. Blood and Transfusion Management in Benign Liver Tumors -- 25. Fast Track Programs in Benign Liver Tumors.
Format
e-Book
Location
Online
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Bioceramics and Alternative Bearings in Joint Arthroplasty : 11th BIOLOX Symposium Rome, June 30-July 1, 2006 Proceedings

https://libcat.nshealth.ca/en/permalink/provcat30030
edited by Francesco Benazzo, Francesco Falez, Martin Dietrich. --Darmstadt: Steinkopff Verlag , c2006.
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Location
Online
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Author
Benazzo, Francesco
Other Authors
International BIOLOX Symposium (11th : 2005 : Rome, Italy)
Other Authors
Falez, Francesco
Dietrich, Martin
Responsibility
edited by Francesco Benazzo, Francesco Falez, Martin Dietrich
Place of Publication
Darmstadt
Publisher
Steinkopff Verlag
Date of Publication
c2006
Series Title
Ceramics in orthopaedics
ISBN
9783798516359
Subjects (MeSH)
Arthroplasty - methods - Congresses
Ceramics - therapeutic use - Congresses
Joint Prosthesis - Congresses
Subjects (LCSH)
Orthopedic surgery
Format
e-Book
Location
Online
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Biostatistics for Radiologists : Planning, Performing, and Writing a Radiologic Study

https://libcat.nshealth.ca/en/permalink/provcat29137
by Francesco Sardanelli, Giovanni Leo. --Milan: Springer , c2009.
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Location
Online
Available Online
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Author
Sardanelli, Francesco
Other Authors
Leo, Giovanni
Responsibility
by Francesco Sardanelli, Giovanni Leo
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2009
ISBN
9788847011335
Subjects (MeSH)
Biometry
Radiography
Research Design
Statistics as Topic
Subjects (LCSH)
Radiology, Medical
Statistics
Format
e-Book
Location
Online
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Bisphosphonates and Osteonecrosis of the Jaw : A Multidisciplinary Approach

https://libcat.nshealth.ca/en/permalink/provcat31225
Francesco Saverio De Ponte, editor ; foreword by Giorgio Iannetti. --Milan: Springer , c2012.
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Online
Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing ONJ are much higher for cancer patients on intravenous bisphosphonate therapy (used to reduce bone pain), the occurrence of ONJ also in patients treated…
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Author
De Ponte, Francesco Saverio
Responsibility
Francesco Saverio De Ponte, editor ; foreword by Giorgio Iannetti
Place of Publication
Milan
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xiii, 181 p. : 98 ill., 76 ill. in color)
ISBN
9788847020832
Subjects (MeSH)
Bisphosphonate-Associated Osteonecrosis of the Jaw - etiology
Bisphosphonate-Associated Osteonecrosis of the Jaw - therapy
Diphosphonates - adverse effects
Subjects (LCSH)
Dentistry
Pharmacy
Family medicine
Radiology, Medical
Hematology
Surgery
Abstract
Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing ONJ are much higher for cancer patients on intravenous bisphosphonate therapy (used to reduce bone pain), the occurrence of ONJ also in patients treated with oral BF for osteoporosis has been also highlighted, though rarely. On the basis of the large use of BF, of their pharmacokinetics, of the systemic and local risk factors, physicians prescribing them and dental surgeons should be well informed on the various aspects of the problem. Aim of this volume is to offer an update on the current status of prevention, and on the current conservative and surgical treatments. The multidisciplinary approach will be very much appreciated by GP's, the different specialists using bisphosphonates and by dental surgeons.
Format
e-Book
Location
Online
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Bone Metastases from Prostate Cancer : Biology, Diagnosis and Management

https://libcat.nshealth.ca/en/permalink/provcat41417
Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, Riccardo Valdagni, editors. --Cham: Springer , 2017.
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Online
This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory,…
Available Online
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Other Authors
Bertoldo, Francesco
Boccardo, Francesco
Bombardieri, Emilio
Evangelista, Laura
Valdagni, Riccardo
Responsibility
Francesco Bertoldo, Francesco Boccardo, Emilio Bombardieri, Laura Evangelista, Riccardo Valdagni, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (x, 293 pages) : 63 illus., 40 illus. in color
ISBN
9783319423272
9783319423265 (print ed.)
Subjects (MeSH)
Bone Neoplasms - diagnosis
Bone Neoplasms - therapy
Neoplasm Metastasis
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Abstract
This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.
Contents
1. Biology and Pathophysiology of Bone Metastasis in Prostate Cancer -- 2. Markers of Bone Turnover in Bone Metastasis from Prostate Cancer -- 3. Bone Homing and Metastasis -- 4. Markers of Prostate Cancer: The Role of Circulating Tumor Markers in the Management of Bone Metastases -- 5. Circulating Tumor Cells (CTCs) and Metastatic Prostate Cancer (mPCa) -- 6. Nuclear Medicine Modalities to Image Bone Metastases with Bone-Targeting Agents: Conventional Scintigraphy and Positron-Emission Tomography -- 7. Detection of Bone Metastases and Evaluation of Therapy Response in Prostate Cancer Patients by Radiolabelled Choline PET/CT -- 8. Imaging of Glycolysis with 18F- FDG PET -- 9. New Radiopharmaceutical Markers for Metabolism and Receptor -- 10. Bone Metastases from Prostate Cancer: Hormonal Therapy -- 11. Chemotherapy -- 12. Combinations of Hormonal Therapy and Chemotherapy -- 13. Surgery: Treatment of Oligometastatic Disease -- 14. Bone Metastases from Prostate Cancer: Radiotherapy -- 15. Bone-Targeted Agents -- 16. Bone-Seeking Radionuclide for Therapy -- 17. New Frontiers in Treatment -- 18. Approaches for Assessment of Response of Bone Metastases to Therapies -- 19. Bone Metastases from Prostate Cancer: From Symptom Control to Pain Palliation -- 20. Economic Impact of Prostate Cancer Bone Metastases -- 21. Multidisciplinary Approach of Prostate Cancer Patients.
Format
e-Book
Location
Online
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Breast MRI for High-risk Screening

https://libcat.nshealth.ca/en/permalink/provcat46097
Francesco Sardanelli, Franca Podo, editors. --Cham: Springer , c2020.
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Location
Online
This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomi…
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Other Authors
Sardanelli, Francesco
Podo, Franca
Responsibility
Francesco Sardanelli, Franca Podo, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxiii, 376 p.) : 84 illus., 32 illus. in color
ISBN
9783030412074
9783030412067 (Print ed.)
9783030412081 (Print ed.)
9783030412098 (Print ed.)
Subjects (MeSH)
Breast Neoplasms - diagnosis
Diagnostic Screening Programs
Female
Genetic Predisposition to Disease
Magnetic Resonance Imaging - methods
Specialty
Diagnostic Imaging
Gynecology
Abstract
This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomics of breast cancer in high-risk women, computer-aided detection/diagnosis and machine learning systems applied to breast MRI, and psycho-oncology issues. Alternatives to breast MRI screening such as pharmaco-prevention and prophylactic mastectomy are also discussed, taking into account the public debate on the “Angelina Jolie” effect. The high breast cancer risk model is proposed as a paradigm for personalized medicine. This book will be of interest to radiologists, surgeons, oncologists and to all professionals devoted to female healthcare.
Contents
1. From NMR to Clinical Breast MRI -- 2. The Mantra about Low Specificity of Breast MRI -- 3. Hereditary Breast Cancer: BRCA and Other Susceptibility Genes -- 4. MRI Protocols for Breast Cancer Screening -- 5. Gadolinium-Based Contrast Agents for Breast MRI and Uncertainties About Brain Gadolinium Retention -- 6. Applying the MRI BI-RADS in a High-Risk Population -- 7. CAD and Machine Learning for Breast MRI -- 8. Radiogenomics and Phenotype Presentation of Breast Cancer with a Special Focus on High-Risk Women -- 9. Primary Studies on Breast MRI Screening of High-Risk Women -- 10. Genetic/Familial High-Risk Screening: MRI Alone? -- 11. Systematic Reviews, Meta-Analyses, and Cost-Effective Analyses on Breast MRI Screening of High-Risk Women -- 12. Radioprotection Issues for Women with Hereditary Predisposition for Breast Cancer -- 13. Impact of MRI Screening on High-Risk Patient Outcome -- 14. The Special Case of Previous Chest Radiation Therapy -- 15. Electronic Data Capture Systems for Breast Cancer Research -- 16. Guidelines and Recommendations on High-Risk Breast Cancer Screening All Over the World: Agreements and Differences -- 17. A Soft Option for Primary Prevention: Drugs and Agents -- 18. Surgical Options for Primary Prevention: Prophylactic Mastectomy and Oophorectomy -- 19. Psychological Aspects of High Risk of Breast Cancer -- 20. Calculating, Using and Improving Individual Breast Cancer Risk Estimates -- 21. MRI for Screening Women with a Personal History of Breast Cancer -- 22. Breast MRI Screening for the Intermediate Risk: An Open Issue -- 23. Hypotheses for the Future.
Format
e-Book
Location
Online
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Canine and Feline Skin Cytology : A Comprehensive and Illustrated Guide to the Interpretation of Skin Lesions via Cytological Examination

https://libcat.nshealth.ca/en/permalink/provcat41380
Francesco Albanese. --Cham: Springer , 2017.
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Online
This book discusses canine and feline skin cytology and the importance of this diagnostic tool in interpreting skin lesions. With more than 600 clinical and cytological color pictures, it explains the cytological patterns observed in all cutaneous inflammatory and neoplastic lesions in cats and dogs, as well as cutaneous metastasis of non-primary skin neoplasms. The first part of the book describes cell morphology and cytological patterns, providing an overview of the normal structure of the sk…
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Author
Albanese, Francesco
Responsibility
Francesco Albanese
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xvii, 524 pages) : 754 illus., 753 illus. in color
ISBN
9783319412412
9783319412399 (print ed.)
Subjects (MeSH)
Cats
Dogs
Skin Diseases - pathology
Skin Neoplasms - pathology
Abstract
This book discusses canine and feline skin cytology and the importance of this diagnostic tool in interpreting skin lesions. With more than 600 clinical and cytological color pictures, it explains the cytological patterns observed in all cutaneous inflammatory and neoplastic lesions in cats and dogs, as well as cutaneous metastasis of non-primary skin neoplasms. The first part of the book describes cell morphology and cytological patterns, providing an overview of the normal structure of the skin. In the second chapter, readers learn how to choose the best techniques for different types of lesions. Further chapters present the cytological findings in the main inflammatory and neoplastic skin diseases. By focusing on the macroscopic aspects of the lesions from which the cells are collected, it helps readers to interpret cytological specimens. The final chapter explores the cytology of cutaneous metastasis from internal organs or accessory glands. This book offers veterinary students and practitioners alike an essential diagnostic tool.
Contents
1. Morphology and Function of Skin Cells -- 2. Techniques of Sampling, Preparation and Staining of Cytological Specimens -- 3. Cytology of Canine and Feline Non Neoplastic Skin Diseases -- 4. Cytology of Skin Tumors -- 5. Cutaneous Metastasis from Non Primary Skin Tumors.
Format
e-Book
Publication Type
Atlas
Location
Online
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Cellular Primary Immunodeficiencies

https://libcat.nshealth.ca/en/permalink/provcat46913
Mario Milco D'Elios, Cosima Tatiana Baldari, Francesco Annunziato. Springer , 2021.
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Location
Online
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Responsibility
Mario Milco D'Elios, Cosima Tatiana Baldari, Francesco Annunziato
Publisher
Springer
Date of Publication
2021
Physical Description
1 online resource (xiv, 513 pages) : illustrations
Series Title
Rare diseases of the immune system
ISBN
9783030701079
Specialty
Allergy and Immunology
Cell Biology
Format
e-Book
Location
Online
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Clinical strategies in the management of diabetic retinopathy : a step-by-step guide for ophthalmologists

https://libcat.nshealth.ca/en/permalink/provcat33837
Francesco Bandello, Marco Attilio Zarbin, Rosangela Lattanzio, Ilaria Zucchiatti, editors. --Heidelberg: Springer , c2014.
Available Online
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Location
Online
Diabetic retinopathy (DR) and its dramatic and sight-threatening complications, such as diabetic macular edema, remain a leading cause of visual impairment among the working-age population. With the advent of effective treatments, a new era in the management of DR has been opened up: it is now possible for patients to regain a degree of visual acuity not previously expected. However, amid the deluge of approved treatments and promising new strategies, clinicians may find it difficult to choose …
Available Online
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Other Authors
Bandello, F.
Zarbin, Marco A.
Lattanzio, R.
Zucchiatti, Ilaria
Responsibility
Francesco Bandello, Marco Attilio Zarbin, Rosangela Lattanzio, Ilaria Zucchiatti, editors
Place of Publication
Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xviii, 178 pages)
ISBN
9783642545030 (electronic bk.)
9783642545023
Subjects (MeSH)
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - therapy
Risk Factors
Subjects (LCSH)
Diabetic retinopathy
Retina - Diseases
Abstract
Diabetic retinopathy (DR) and its dramatic and sight-threatening complications, such as diabetic macular edema, remain a leading cause of visual impairment among the working-age population. With the advent of effective treatments, a new era in the management of DR has been opened up: it is now possible for patients to regain a degree of visual acuity not previously expected. However, amid the deluge of approved treatments and promising new strategies, clinicians may find it difficult to choose the appropriate practice in each individual case. The purpose of this easy-to-use and richly illustrated manual is to assist ophthalmologists in making decisions in the entire management of DR based on the best available evidence. Practical and complete recommendations are provided to guide clinicians in diagnosis, decision-making, and treatment. The manual includes practical algorithms and case histories relating to all stages of DR that clearly explain the progression of the disease and will help the clinician to choose the best therapeutic approach. It will be an ideal resource for ophthalmologists aiming to provide optimal clinical management for this sight-threatening disease.
Contents
Epidemiology, Risk Factors, and Pathophysiology of Diabetic Retinopathy -- Non-proliferative Diabetic Retinopathy -- Diabetic Macular Edema -- Proliferative Diabetic Retinopathy -- Advanced Proliferative Diabetic Retinopathy.
Format
e-Book
Location
Online
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