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Blood pressure and arterial wall mechanics in cardiovascular diseases

https://libcat.nshealth.ca/en/permalink/provcat33886
Michel E. Safar, Michael F. O'Rourke, Edward D. Frohlich, editors. --London: Springer , c2014.
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In cardiovascular prevention, therehastraditionallybeena small number of cardiovascular risk factors to evaluate and manage, such as hypertension, diabetes,hyperlipidemiaand smoking. Recently, it has been recognized that new mechanical factors should be identified, andspecificallyinvolves pulsatile arterial hemodynamic parameters, such asarterial stiffness, pulse pressure and, to a lesser extent, augmentation index and pulse pressure amplification. Blood Pressure and Arterial Wall Mechanics in …
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Other Authors
Safar, Michel
O'Rourke, Michael F.
Frohlich, Edward D.
Responsibility
Michel E. Safar, Michael F. O'Rourke, Edward D. Frohlich, editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xx, 567 pages)
ISBN
9781447151982 (electronic bk.)
9781447151975
Subjects (MeSH)
Blood Pressure
Vascular Stiffness - physiology
Subjects (LCSH)
Cardiology
Cardiovascular system - Diseases
Blood pressure
Arteries - Physiology
Abstract
In cardiovascular prevention, therehastraditionallybeena small number of cardiovascular risk factors to evaluate and manage, such as hypertension, diabetes,hyperlipidemiaand smoking. Recently, it has been recognized that new mechanical factors should be identified, andspecificallyinvolves pulsatile arterial hemodynamic parameters, such asarterial stiffness, pulse pressure and, to a lesser extent, augmentation index and pulse pressure amplification. Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseaseshas been written to facilitate understanding of these new concepts regarding bleed pressure and cardiac risk, and prepare the reader for the considerable evolution of the topic in the years to come. Much has been learned already regarding the management of these patients, and this book presents extensive data on the techniques needed to maximize their outcomes.
Contents
Part I. Blood Pressure: Basic Concepts of Steady and Pulsatile Arterial Hemodynamics -- 1. Arterial Stiffness, Wave Reflection, Wave Amplification: Basic Concepts, Principles of Measurement and Analysis in Humans -- 2. Large Arteries, Microcirculation, and Mechanisms of Hypertension -- 3. Direct Measurement of Local Arterial Stiffness and Pulse Pressure -- 4. Ventricular-Arterial Coupling and Mechanism of Wave Reflections -- 5. Determination of Systemic and Regional Arterial Structure and Function -- 6. Animal Models for Studies of Arterial Stiffness -- 7. Elastin, Calcium and Age-Related Stiffening of the Arterial Wall -- 8. Genetic and Cellular Aspects of Arterial Stiffness -- Part II. Blood Pressure and Sodium Balance: Pathophysiological Mechanisms and Cardiovascular Risk -- 9. Mechanical Stress and the Arterial Wall -- 10. Pulsatile Stress, Arterial Stiffness, and Endothelial Function -- 11. Hypoxia, Arterial Blood Pressure, and Microcirculation -- 12. The Reality of Aging Viewed from the Arterial Wall -- 13. Emerging Aspects of Angiotensin Biology and Their Potential Role in the Vasculature -- 14. Arterial Stiffness and the Sympathetic Nervous System -- 15. Oxidative Stress and Hypertension -- 16. Heart Failure with Preserved Ejection Fraction -- 17. Structural Alterations in Arterial Stiffness: Role of Arterial Fibrosis -- 18. Salt and Multiorgan Damage in Hypertension: Vascular Stiffening and Cardiorenal Structural Dysfunction Responses -- 19. Preventive Lessons from Hypertension and Myocardial Infarction: Treating Asymptomatic Individuals to Lower the Risk for Subsequent Cardiovascular Events -- Part III. Hypertension: Evaluation of Cardiovascular Risk and Organ Damage -- 20. Value of Brachial and Central Blood Pressure for Predicting Cardiovascular Events -- 21. Predictive Value of Arterial Stiffness for Cardiovascular Events -- 22. Heart Rate, Synchrony and Arterial Hemodynamics -- 23. Pulse Pressure Amplification and Arterial Stiffness in Middle Age -- 24. Arterial Stiffness, Central Blood Pressure and Cardiac Remodelling: From Cardiac Hypertrophy to Heart Failure -- 25. The Relationship Between Aortic Stiffness, Microvascular Disease in the Brain and Cognitive Decline: Insights into the Emerging Epidemic of Alzheimer’s Disease -- 26. Arterial Stiffness and Risk in Various Cardiovascular Diseases -- 27. Large Artery Remodeling and Chronic Kidney Disease -- 28. Arterial Changes in Renal Transplantation -- 29. Arterial Stiffness, Central Blood Pressure and Coronary Heart Disease -- Part IV. Clinical Involvement: Role of Age, Sex, Inflammatory and Metabolic Alterations -- 30. Modifications of Blood Pressure Profiles in the Very Old: Role of Frailty and Comorbidities -- 31. Arterial Stiffness and Amplification in the Very Old -- 32. Hypertension in Men and Women: Is It Different? -- 33. Obesity, Metabolic Syndrome, Diabetes and Smoking -- 34. Glucose, Insulin and Potential Strategies of Vascular Stiffening -- 35. Arterial Stiffness in Chronic Inflammation -- Part V. Stratifications of Cardiovascular Risk and Therapeutic Consequences on Arterial Stiffness and Wave Reflections -- 36. Outcome-Driven Thresholds for Pulse Pressure on Office and Out-of-the-Office Blood Pressure Measurement -- 37. Properties of Central Arteries in Populations of Different Ethnicity: Ethnicity and Central Arteries -- 38. Changing Concepts on the Role of Blood Pressure Reduction in Stroke Prevention with the Focus on ß-Blocking Agents -- 39. Decreasing Arterial Stiffness and/or Wave Reflections Independently of Mean Arterial Pressure: Effect of Antihypertensive Drugs (Part 1) -- 40. Decreasing Arterial Stiffness and/or Wave Reflections Independently of Mean Arterial Pressure: Effect of Non-antihypertensive Drugs (Part 2) -- 41. Blood Pressure Variability: Measurements, Influential Factors, Prognosis and Therapy -- 42. Nitrate: The Ideal Drug Action for Isolated Systolic Hypertension in Elderly? -- 43. De-stiffening Strategy, Sodium Balance, and Blockade of the Renin–Angiotensin System -- 44. Long-Term Effects of Calcium Channel Blockers on Central and Peripheral Arteries -- 45. Exercise Training for the Modification of Arterial Stiffness and Wave Reflections.
Format
e-Book
Location
Online
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The Local Cardiac Renin-Angiotensin Aldosterone System

https://libcat.nshealth.ca/en/permalink/provcat29683
Edward D. Frohlich, Richard N. Re, editors. (2nd ed.) --Boston, MA: Springer-Verlag US , c2009.
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How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. Howev…
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Author
Frohlich, Edward D
Other Authors
International Workshop on the Local Cardiac Renin Angiotensin Aldosterone System (3rd : 2008 : New Orleans, La.)
Other Authors
Re, Richard N
Responsibility
Edward D. Frohlich, Richard N. Re, editors
Edition
2nd ed.
Place of Publication
Boston, MA
Publisher
Springer-Verlag US
Date of Publication
c2009
ISBN
9781441905284
Subjects (MeSH)
Cardiology - Congresses
Hypertension - metabolism
Receptors, Cell Surface - physiology
Renin-Angiotensin System - physiology
Vacuolar Proton-Translocating ATPases - metabolism
Subjects (LCSH)
Cardiology
Physiology
Abstract
How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. However, it wasn't until the simultaneous finding by two different geographically separated teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released from the kidney and catalyzed a biochemical cascade which was eventually shown to produce the elevated arterial pressure. Subsequently, many workers contributed to the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the enzyme renin acted upon its protein substrate, produced in the liver, to liberate the decapeptide angiotensin I which, upon circulating through the pulmonary circulation, finally produced the potent octapeptide angiotensin. Several important subsequent findings demonstrated that angiotensin I1 promoted the release of the adrenal corticosteroid from that gland, thereby resulting in a larger system, the renin-angiotensin-aldosterone system. Further, this system demonstrated a classical biofeedback and the circulating octapeptide was shown to have additional biological activities in organs other than heart, vessels, kidney, adrenals, and even brain.
Contents
1. Are Local Renin–Angiotensin Systems the Focal Points for Understanding Salt Sensitivity in Hypertension? -- 2. Newer Insights into the Biochemical Physiology of the Renin–Angiotensin System: Role of Angiotensin-(1-7), Angiotensin Converting Enzyme 2, and Angiotensin-(1-12) -- 3. Renin, Prorenin, and the (Pro)renin Receptor -- 4. Intracellular Accumulation and Nuclear Trafficking of Angiotensin II and the Angiotensin II Type 1 Receptor -- 5. Pathophysiologic Implications of Cell Swelling in the Failing Heart: Influence of Intracrine and Extracellular Renin–Angiotensin Systems -- 6. Exploiting Rat Genetics to Investigate Hypertensive End-Organ Damage -- 7. Alternative Renin Transcripts and Functions of Cytoplasmatic Renin -- 8. Novel Aspects of the Cardiac Renin–Angiotensin System -- 9. Intracrine Function from Angiotensin to Stem Cells -- 10. Renin Cell Identity and Homeostasis -- 11. Role of Renal Aminopeptidases and Angiotensin Type-2 (AT2) Receptors in Sodium Excretion and Hypertension -- 12. Intrarenal Angiotensin II Augmentation in Hypertension -- 13. Collecting Duct Renin: A Critical Link in Angiotensin II-Dependent Hypertension -- 14. Renin–Angiotensin–Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease -- 15. Upregulation of Angiotensin II Type 2 Receptor (agtr2) Attenuates Atherosclerotic Lesion Formation and Enhances Apoptosis in the LDL Receptor Knockout Mice Fed High Cholesterol Diet -- 16. Salt and Heart: RAAS Involvement -- 17. Cardiac Effects of Aldosterone, the Bad, but Is There Also a Good?
Format
e-Book
Location
Online
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