The field of structural heart disease interventions is experiencing a stage of rapid growth with the development of percutaneous mitral valve repair therapies and percutaneous aortic valve replacement therapies. The MitraClip represents a new therapeutic frontier for mitral regurgitation and is expected to revolutionize repair of the mitral valve. For the first time in the world, physicians now have the capability to repair the mitral valve percutaneously without the need for a sternotomy or ca…
This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). The purpose for this publication is to fill the gap between the growing clinical relevance and utilization of immunotherapy in medical oncology, mainly based on checkpoint inhibitors, and the need for experienced imagers with relia…
This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical developmen…
This book explores, through case studies, the interplay between religion, culture, government, and politics in diverse societies on questions arising in the domain of bioethics. The case studies draw from multiple disciplinary perspectives, including history, theology, law, bioethics, public policy, science, and medicine. The text's global perspective permits a comparison of the differing approaches adopted by countries facing similar bioethical quandaries and the extent to which religion has o…
This book is a practical guide for the use of simulation in neurosurgery, with chapters covering high fidelity simulation, animal models simulation, cadaveric simulation, and virtual reality simulation. Readers are introduced to the different simulation modalities and technologies and are guided on the use of simulation for a variety of learners, including medical students, residents, practicing pediatricians, and health-related professionals. Comprehensive Healthcare Simulation: Neurosurgery i…
The promise and prospects for mobile technologies in healthcare service delivery'particularly as experienced by patients and other users'are the focus of this forward-looking volume. Its detailed sociotechnical perspective takes in factors influencing patient and provider adoption of technological advances, in addition to the well-known cost and accessibility advantages. Enlightening reports show mobile health technologies in multiple contexts as an impetus for behavioral change, a means of mon…
This in-depth book addresses a key void in the literature surrounding the Internet of Things (IoT) and health. By systematically evaluating the benefits of mobile, wireless, and sensor-based IoT technologies when used in health and wellness contexts, the book sheds light on the next frontier for healthcare delivery. These technologies generate data with significant potential to enable superior care delivery, self-empowerment, and wellness management. Collecting valuable insights and recommendat…
In the fourth edition of this gold-standard title, a distinguished panel of experts provides a thorough update of the significant improvements in our understanding of diabetic foot physiology and its clinical management. Divided into three sections, the first part focuses on clinical features and diagnosis; the second on pathophysiology; and the third on the management of diabetic foot problems. In addition to updating all previous chapters, several new contributions have been added, reflecting…
Biobank research and genomic information are changing the way we look at health and medicine. Genomics challenges our values and has always been controversial and difficult to regulate. In the future lies the promise of tailored medical treatments and pharmacogenomics but the borders between medical research and clinical practice are becoming blurred. We see sequencing platforms for research that can have diagnostic value for patients. Clinical applications and research have been kept separate,…
How long can humans live? This open access book documents, verifies and brings to life the advance of the frontier of human survival. It carefully validates data on supercentenarians, aged 110+, and semi-supercentenarians, aged 105-109, stored in the International Database on Longevity (IDL). The chapters in this book contribute substantial advances in rigorously checked facts about exceptional lifespans and in the application of state-of-the-art analytical strategies to understand trends and p…
This book provides a historical analysis of the Frontier Nursing Services in the Eastern Appalachians of the United States, as well as a review of the oral history tradition of former frontier and non-frontier nurses. The data was gathered from 2003 to 2007, and the historical part covers the years 1900 to 1970. The objective of the study presented here was to conduct interviews with former frontier and non-frontier nurses in order to better understand their family and personal relationships, a…
The 24th volume of this highly successful series includes new contemporary topics such as corrosive injuries of the oesophagus, post-gastrectomy complications, advances in imaging of inflammatory bowel disease, unusual presentations of gallstones, gall bladder cancer with jaundice, minimally invasive pancreatic surgery, and enhanced recovery after surgery. Finally, the chapter on advances in GI surgery, like in each past volume, reviews important new developments in the field. The GI Surgery An…
Forced migration has yet to be sufficiently addressed from the perspective of health policy and systems research, resulting in limited knowledge on system-level interventions and policies to improve the health of forced migrants. The contributions within this edited volume seek to rectify this gap in the literature by compiling the existing knowledge on health systems and health policy responses to forced migration with a focus on asylum seekers, refugees, and internally displaced people. It al…
A timely work describing how localized hospital-based health technology assessment (HB-HTA) complements general, "arms-length" HTA agency efforts, and what has been the collective global impact of HB-HTA across the globe. While HB-HTA has gained significant momentum over the past few years, expertise in the field, and information on the operation and organization of HB-HTA, has been scattered. This book serves to bring this information together to inform those who are currently working in the f…
In Vitro Fertilization: A Comprehensive Guide represents the next frontier in the integrated clinical and laboratory practice of ART. Uniquely balanced, the book provides the necessary understanding of the key laboratory techniques involved in ART and the complex aspects of clinical care. Featuring the contributions of world leaders in the field, the guide begins with the evaluation of the infertile woman and man. It then moves on to discuss treatment protocols and adjunctive treatments. Techni…
Consisting of case studies contributed by both domestic and international leaders in the field, Limb Lengthening and Reconstruction: A Case-Based Atlas will be an invaluable resource for all orthopedic surgeons and researchers and practitioners of limb lengthening, deformity correction and the Ilizarov method. Comprehensive yet accessible, it will cover pediatrics, foot and ankle, trauma and post-traumatic reconstruction, adult deformity, tumor and upper extremity interventions in dedicated sec…
Consisting of case studies contributed by both domestic and international leaders in the field, this is an invaluable resource for all orthopedic surgeons and researchers and practitioners of limb lengthening, deformity correction and the Ilizarov method. Comprehensive yet accessible, this volume covers pediatric deformity correction, from congenital deformities to growth plate injuries. Each of the unique cases includes color photographs and radiographs from before, during and after surgery an…
Consisting of case studies contributed by both domestic and international leaders in the field, this is an invaluable resource for all orthopedic surgeons and researchers and practitioners of limb lengthening, deformity correction and the Ilizarov method. Comprehensive yet accessible, this volume covers injuries to the foot and ankle as well as orthopedic trauma, from foot and ankle fusions and clubfoot correction to femoral and tibial reconstruction. Each of the unique cases includes color pho…
Consisting of case studies contributed by both domestic and international leaders in the field, this is an invaluable resource for all orthopedic surgeons and researchers and practitioners of limb lengthening, deformity correction and the Ilizarov method. Comprehensive yet accessible, this volume covers injuries to the upper extremity, adult deformity correction and bone tumors, from humeral lengthening and femoral deformity to amputation reconstruction and reconstruction after benign and malig…