Apolipoprotein Mimetics in the Management of Human Disease
https://libcat.nshealth.ca/en/permalink/provcat39279
G.M. Anantharamaiah, Dennis Goldberg, editors.
--Cham:
Springer International Publishing : Imprint: Adis
, c2015.
- Available Online
- View e-Book
- Location
- Online
This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of t…
- Available Online
- View e-Book
- Other Authors
- Anantharamaiah, G.M
- Goldberg, Dennis
- Responsibility
- G.M. Anantharamaiah, Dennis Goldberg, editors
- Place of Publication
- Cham
- Publisher
- Springer International Publishing : Imprint: Adis
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xxi, 182 p. : 42 illus., 22 illus. in color)
- ISBN
- 9783319173504
- 9783319173498 (print ed.)
- Subjects (MeSH)
- Apolipoproteins - therapeutic use
- Biomimetics
- Abstract
- This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of the Journal Lipid Research, the book presents a narration of how a theory can lead to the discovery of treatment modalities to several devastating diseases such as diabetes, Alzheimer's disease, arthritis; asthma; atherosclerosis, chronic rejection of transplanted hearts and cancer. Present therapies for most of these diseases are not adequate. Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases. The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book.
- Contents
- 1. HDL and the Amphipathic Helix -- 2. ApoA-I mimetic peptides: A review of the present status -- 3. Apolipoprotein Mimetic Peptides for Stimulating Cholesterol Efflux -- 4. ApoA-I Mimetic Peptides and Diabetes -- 5. Apolipoprotein A-I mimetic peptides in Mouse Models of Cancer -- 6. Effects of ApoA-I mimetic peptide L-4F in LPS-mediated inflammation -- 7. Apolipoprotein mimetics in the amelioration of respiratory inflammation -- 8. Regulation of Macrophage Polarity by HDL, Apolipoproteins And Apolipoprotein Mimetic Peptides -- 9. Apolipoprotein E & Atherosclerosis: Beyond Lipid Effects -- 10. Apolipoprotein E mimetic peptides: Cholesterol dependent and independent properties -- 11. Apolipoprotein-E and Mimetics as Targets and Therapeutics for Alzheimer's Disease.
- Format
- e-Book
- Location
- Online
Preventive and Predictive Genetics : Towards Personalised Medicine
https://libcat.nshealth.ca/en/permalink/provcat39215
Godfrey Grech, Iris Grossman, editors.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
Traditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical research. While epidemiology and gross pathology are still mainstay useful tools, genetics and genomics have gradually been shown to increase the resolution of drug response research, showing great potentia…
- Available Online
- View e-Book
- Other Authors
- Grech, Godfrey
- Grossman, Iris
- Responsibility
- Godfrey Grech, Iris Grossman, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xx, 378 p. : 18 illus., 8 illus. in color)
- Series Vol.
- v. 9
- ISBN
- 9783319153445
- 9783319153438 (print ed.)
- ISSN
- 2211-3495
- Abstract
- Traditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical research. While epidemiology and gross pathology are still mainstay useful tools, genetics and genomics have gradually been shown to increase the resolution of drug response research, showing great potential in also informing and identifying the role of genes and their encoded products in the pathophysiology of diseases. This information is already being applied in the prevention of illness, effective early diagnosis, better risk assessment (prognosis), as well as targeted effective and safe treatment allocation (prediction and monitoring). Genetic testing and genomics support personalised medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalised medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.
- Contents
- Introduction -- Preventive and Predictive Genetics: a perspective -- Roadmap to Drug Development Enabled by Pharmacogenetics -- Preventative and Predictive Genetics: Towards Personalised Medicine -- Pharmacokinetics and Pharmacogenetics: bringing the magic bullet closer to reality -- Pharmacogenetics of Adverse Drug Reactions -- Pharmacogenomics for Haemoglobinopathies Therapeutics -- Pharmacogenetics of Neurodegenerative Disorders -- Pharmacogenetics of Asthma -- Pharmacogenetics and Antineoplastic Therapies -- Pharmacogenetics of Coumarin Anticoagulant Therapy -- Implementation of Genomic Medicine: tools and challenges -- Ethical Considerations in the Genomic Era.
- Format
- e-Book
- Location
- Online
Quality by design : a clinical microsystems approach
https://libcat.nshealth.ca/en/permalink/provcat23455
Eugene C. Nelson, Paul B. Batalden, Marjorie M. Godfrey, editors ; foreword by Donald M. Berkwick.
--San Francisco, CA:
Jossey-Bass
, c2007.
- Call Number
- HD 57.7 N425q 2007
- Location
- Halifax Infirmary
- Nova Scotia Hospital
- Dickson Building
- Call Number
- HD 57.7 N425q 2007
- Author
- Nelson, Eugene C.
- Other Authors
- Batalden, Paul B.
- Godfrey, Marjorie M.
- Responsibility
- Eugene C. Nelson, Paul B. Batalden, Marjorie M. Godfrey, editors ; foreword by Donald M. Berkwick
- Place of Publication
- San Francisco, CA
- Publisher
- Jossey-Bass
- Date of Publication
- c2007
- Physical Description
- xxliv, 459 p. : ill.
- ISBN
- 9780787978983
- Subjects (MeSH)
- Delivery of Health Care - organization & administration
- Health Services Administration
- Models, Organizational
- Quality Assurance, Health Care
- Quality Improvement
- Quality Indicators, Health Care
- Format
- Book
- Location
- Halifax Infirmary
- Nova Scotia Hospital
- Dickson Building
- Copies
- 3
- Loan Period
- 3 weeks
Treatment of Dry Skin Syndrome : The Art and Science of Moisturizers
https://libcat.nshealth.ca/en/permalink/provcat31172
Marie Lodén, Howard I. Maibach, editors.
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Dry skin impacts on the lives of many individuals but in most cases it can be adequately managed with current moisturizing products. Certain moisturizers, however, can themselves adversely affect the quality of life by inducing further dryness and eczema and so becoming addictive. In addition, there is a possible link between moisturizing treatments and asthma. Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the…
- Available Online
- View e-Book
- Other Authors
- Lodén, Marie
- Maibach, Howard I
- Responsibility
- Marie Lodén, Howard I. Maibach, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxxvii, 591 p. : 145 ill., 50 ill. in color)
- ISBN
- 9783642276064
- Subjects (MeSH)
- Dermatitis - drug therapy
- Emollients - therapeutic use
- Skin Care
- Skin Diseases - drug therapy
- Subjects (LCSH)
- Dermatology
- Biochemistry
- Abstract
- Dry skin impacts on the lives of many individuals but in most cases it can be adequately managed with current moisturizing products. Certain moisturizers, however, can themselves adversely affect the quality of life by inducing further dryness and eczema and so becoming addictive. In addition, there is a possible link between moisturizing treatments and asthma. Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.
- Contents
- [Machine generated contents note] Pt. I Marketplace and Treatment Aspects -- 1. Moisturizers as Cosmetics, Medicines, or Medical Device? The Regulatory Demands in the European Union / Marie Loden -- 2. Design of Claims Support for Moisturizers / Judith K. Woodford -- 3. Educational Interventions for the Management of Children with Dry Skin / Noreen Heer Nicol -- 4. Dry Skin in Childhood and the Misery of Eczema and Its Treatments / Susan Lewis-Jones -- 5. Use of Moisturizers in Patients with Atopic Dermatitis / Alexander K.C. Leung -- Pt. II Skin Essentials -- 6. Sensory Systems of Epidermal Keratinocytes / Mitsuhiro Denda -- 7. Sensitive Skin: Intrinsic and Extrinsic Contributors / Michael K. Robinson -- 8. Electron Tomography of Skin / Lars Norlen -- 9. Filaggrin Gene Defects and Dry Skin Barrier Function / Jacob P. Thyssen -- 10. Molecular Organization of the Lipid Matrix in Stratum Corneum and Its Relevance for the Protective Functions of Human Skin / Mila Boncheva -- 11. Desquamation: It Is Almost All About Proteases / Anthony V. Rawlings -- 12. Endogenous Retroviral-Like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization / Takeshi Matsui -- 13. Vernix Caseosa and Its Substitutes: Lipid Composition and Physicochemical Properties / Steven B. Hoath -- 14. Role of Tight Junctions and Aquaporins in Skin Dryness / J.M. Brandner -- 15. Biomechanics of the Barrier Function of Human Stratum Corneum / Reinhold H. Dauskardt -- Pt. III Dry Skin Disorders and Treatments -- 16. Update on Atopic Eczema with Special Focus on Dryness and the Impact of Moisturizers / Eric Simpson -- 17. Update on Hand Eczema with Special Focus on the Impact of Moisturisers / Mark Wilkinson -- 18. Update on Ichthyosis with Special Emphasis on Dryness and the Impact of Moisturizers / Johannes Wohlrab -- 19. Psoriasis and Dry Skin: The Impact of Moisturizers / Razvigor Darlenski -- 20. Update on Infant Skin with Special Focus on Dryness and the Impact of Moisturizers / Neena K. Tierney -- Pt. IV Ingredients and Treatment Effects -- 21. Composition and Development of Moisturizers / Steve Barton -- 22. Ungual Formulations: Topical Treatment of Nail Diseases / Kenneth A. Walters -- 23. Preservation of Moisturisers / D. Godfrey -- 24. Potential Allergens in Moisturizing Creams / An Goossens -- 25. Formulating Moisturizers Using Natural Raw Materials / Swarnlata Saraf -- 26. Chemical and Physical Properties of Emollients / Jari T. Alander -- 27. Polyfunctional Vehicles by the Use of Vegetable Oils / Chiara Andolfatto -- 28. Effect of Natural Moisturizing Factors on the Interaction Between Water Molecules and Keratin / Noriaki Nakagawa -- 29. Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin / David W. Koenig -- 30. Water and Minerals in the Treatment of Dryness / Lawrence Charles Parish -- 31. Hyaluronan Inside and Outside of Skin / Robert Stern -- 32. Glycerol as a Skin Barrier Influencing Humectant / Fabrice Pirot -- 33. Use of Urea in the Treatment of Dry Skin / Marie Loden -- 34. Urea and Skin: A Well-Known Molecule Revisited / Susanne Grether-Beck -- 35. Influence of Climate on the Treatment of Dry Skin with Moisturizer / E. Proksch -- 36. Emollient Therapy and Skin Barrier Function / Majella E. Lane -- 37. Skin Barrier Responses to Moisturizers: Functional and Biochemical Changes / Izabela Buraczewska-Norin -- 38. Changes in Stratum Corneum Thickness, Water Gradients and Hydration by Moisturizers / Joseph R. Kaczvinsky -- 39. Skin Moisture and Heat Transfer / Lee Berk.
- Format
- e-Book
- Location
- Online
