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55 Years German Society of Anaesthesiology and Intensive Care Medicine : Tradition and Innovation

https://libcat.nshealth.ca/en/permalink/provcat31075
editor, Jürgen Schüttler ; on behalf of the German Society of Anaesthesiology and Intensive Care Medicine. --Berlin, Heidelberg: Springer , c2012.
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This book presents to all those who are interested in the history of Anaesthesiology historical details and information on the development of anaesthesiology in Germany and the remarkable growth of our Society. At the founding session of the German Society of Anaesthesia in Munich on 10 April 1953 42 persons had signed the founding documents. Today about 12,000 anaesthetists are members of the German Society of Anaesthesiology and Intensive Care Medicine, making the DGAI the biggest national so…
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Corporate Author
German Society of Anaesthesiology and Intensive Care Medicine
Other Authors
Schüttler, J
Responsibility
editor, Jürgen Schüttler ; on behalf of the German Society of Anaesthesiology and Intensive Care Medicine
Alternate Title
55 Years German Society of Anesthesiology and Intensive Care Medicine
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (x, 220 p. : 180 ill.)
ISBN
9783540682271
Subjects (MeSH)
Anesthesiology - history - Germany
Critical Care - history - Germany
Subjects (LCSH)
Anesthesiology
Critical care medicine
History of Medicine
Abstract
This book presents to all those who are interested in the history of Anaesthesiology historical details and information on the development of anaesthesiology in Germany and the remarkable growth of our Society. At the founding session of the German Society of Anaesthesia in Munich on 10 April 1953 42 persons had signed the founding documents. Today about 12,000 anaesthetists are members of the German Society of Anaesthesiology and Intensive Care Medicine, making the DGAI the biggest national society within ESA. Well known are the pioneering contributions of German scientists and surgeons to the development of general, regional and local anaesthesia during the 19th and the beginning of the 20th centuries. But less known outside Germany are the reasons for the delayed evolution of anaesthesiology as a specialty of its own in German medicine, far later than in the UK, Scandinavia or the USA. In this book you will find answers to this question and detailed information on the successful evolution of anaesthesiology especially at the Faculties of Medicine at German universities.
Format
e-Book
Location
Online
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Abdomen and thoracic imaging : an engineering & clinical perspective

https://libcat.nshealth.ca/en/permalink/provcat33315
Ayman S. El-Baz, Luca Saba, Jasjit Suri, editors. --New York: Springer , c2014.
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This book will cover all the imaging techniques, potential for applying such imaging clinically, and offer present and future applications as applied to the abdomen and thoracic imaging with the most world renowned scientists in these fields. The main aim of this book is to help advance scientific research within the broad field of abdominal imaging. This book focuses on major trends and challenges in this area, and it presents work aimed to identify new techniques and their use in medical imag…
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Other Authors
El-Baz, Ayman S
Saba, Luca
Suri, Jasjit S
Responsibility
Ayman S. El-Baz, Luca Saba, Jasjit Suri, editors
Place of Publication
New York
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (ix, 773 pages)
ISBN
9781461484981 (electronic bk.)
9781461484974
Subjects (MeSH)
Abdomen - pathology
Thorax - pathology
Subjects (LCSH)
Abdomen - Imaging
Chest - Imaging
Diagnostic imaging
Abstract
This book will cover all the imaging techniques, potential for applying such imaging clinically, and offer present and future applications as applied to the abdomen and thoracic imaging with the most world renowned scientists in these fields. The main aim of this book is to help advance scientific research within the broad field of abdominal imaging. This book focuses on major trends and challenges in this area, and it presents work aimed to identify new techniques and their use in medical imaging analysis for abdominal imaging.
Contents
1. Computer-Aided Diagnosis Systems for Acute Renal Transplant Rejection: Challenges and Methodologies -- 2. Kidney Detection and Segmentation in Contrast-Enhanced Ultrasound 3D Images -- 3. Renal Cortex Segmentation on Computed Tomography -- 4. Diffuse Fatty Liver Disease: From Diagnosis to Quantification -- 5. Multimodality Approach to Detection and Characterization of Hepatic Hemangiomas -- 6. Ultrasound Liver Surface and Textural Characterization for the Detection of Liver Cirrhosis -- 7. MR Imaging of Hepatocellular Carcinoma -- 8. Magnetic Resonance Imaging of Adenocarcinoma of the Pancreas -- 9. Quantitative Evaluation of Liver Function Within MR Imaging -- 10. Diffusion-Weighted Imaging of the Liver -- 11. Shape-Based Liver Segmentation Without Prior Statistical Models -- 12. CT Imaging Characteristics of Hepatocellular Carcinoma -- 13. Clinical Applications of Hepatobiliary MR Contrast Agents -- 14. Fast Object Detection Using Color Features for Colonoscopy Quality Measurements -- 15. Colon Surface Registration Using Ricci Flow -- 16. Efficient Topological Cleaning for Visual Colon Surface Flattening -- 17. Towards Self-Parameterized Active Contours for Medical Image Segmentation with Emphasis on Abdomen -- 18. Bridging the Gap Between Modeling of Tumor Growth and Clinical Imaging -- 19. Evaluation of Medical Image Registration by Using High-Accuracy Image Matching Techniques -- 20. Preclinical Visualization of Hypoxia, Proliferation and Glucose Metabolism in Non-small Cell Lung Cancer and Its Metastasis -- 21. Thermoacoustic Imaging with VHF Signal Generation: A New Contrast Mechanism for Cancer Imaging Over Large Fields of View -- 22. Automated Prostate Cancer Localization with Multiparametric Magnetic Resonance Imaging -- 23. Ultrasound-Fluoroscopy Registration for Intraoperative Dynamic Dosimetry in Prostate Brachytherapy -- 24. Multi-Atlas-Based Segmentation of Pelvic Structures from CT Scans for Planning in Prostate Cancer Radiotherapy -- 25. Propagating Segmentation of a Single Example to Similar Images: Differential Segmentation of the Prostate in 3-D MRI -- 26. 3D Registration of Whole-Mount Prostate Histology Images to Ex Vivo Magnetic Resonance Images Using Strand-Shaped Fiducials -- 27. Anatomical Landmark Detection.
Format
e-Book
Location
Online
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Abnormal Female Puberty : A Clinical Casebook

https://libcat.nshealth.ca/en/permalink/provcat40030
Heather L. Appelbaum, editor. --Cham: Springer , c2016.
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Comprised exclusively of clinical cases covering abnormal female puberty and its clinical management, this concise, practical casebook will provide clinicians in reproductive endocrinology, gynecology and pediatrics with the best real-world strategies to properly diagnose and treat the various forms of the condition they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to t…
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Other Authors
Appelbaum, Heather L
Responsibility
Heather L. Appelbaum, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xi, 277 p. : 11 illus., 9 illus. in color)
ISBN
9783319272252
9783319272238 (print ed.)
Subjects (MeSH)
Adolescent Development
Genitalia, Female - abnormalities
Growth Disorders
Puberty
Abstract
Comprised exclusively of clinical cases covering abnormal female puberty and its clinical management, this concise, practical casebook will provide clinicians in reproductive endocrinology, gynecology and pediatrics with the best real-world strategies to properly diagnose and treat the various forms of the condition they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Cases included illustrate different causes of abnormal puberty as well as management strategies, including congenital anomalies, endocrine disorders, issues of constitutional delay, obesity, eating disorders, ovarian cancer and the effect of pharmacology, among others. Pragmatic and reader-friendly, Abnormal Female Puberty: A Clinical Casebook will be an excellent resource for reproductive endocrinologists, gynecologists and pediatricians alike.
Contents
1 Congenital Anomalies and Abnormal Pubertal Development -- 2 Precocious Puberty -- 3 Constitutional Delay of Growth and Puberty -- 4 Premature Ovarian Failure -- 5 Endocrine Disorders and Delayed Puberty -- 6 Androgenic Disorders and Abnormal Pubertal Development -- 7 Impact of Obesity on Female Puberty -- 8 Anorexia Nervosa in the Young Female Adolescent -- 9 The Female Athlete Triad and Abnormal Pubertal Development -- 10 Celiac Disease and Abnormal Pubertal Development -- 11 Ovarian Neoplasms and Abnormal Pubertal Development -- 12 Survivors of Childhood Cancer and Cancer Treatments -- 13 Pharmacological and Environmental Effects on Pubertal Development.
Format
e-Book
Publication Type
Case Reports
Location
Online
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ACL Injury and Its Treatment

https://libcat.nshealth.ca/en/permalink/provcat40415
Mitsuo Ochi, Konsei Shino, Kazunori Yasuda, Masahiro Kurosaka, editors. --Tokyo: Springer Japan , c2016.
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This volume presents detailed information on surgically relevant anatomy and histology of the anterior cruciate ligament (ACL), biomechanics, diagnostics, and ACL reconstruction. In light of the growing body of evidence demonstrating the advantages of anatomic ACL reconstruction over traditional methods, there are also discussions of single anteromedial bundle reconstruction and anatomic ACL reconstruction with abundant descriptions of experimental and clinical studies. In addition, particular …
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Other Authors
Ochi, Mitsuo
Shino, Konsei
Yasuda, Kazunori
Kurosaka, Masahiro
Responsibility
Mitsuo Ochi, Konsei Shino, Kazunori Yasuda, Masahiro Kurosaka, editors
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (xiv, 562 p. : 255 illus., 182 illus. in color)
ISBN
9784431558583
9784431558569 (print ed.)
Subjects (MeSH)
Anterior Cruciate Ligament - injuries
Anterior Cruciate Ligament Reconstruction - methods
Anterior Cruciate Ligament - surgery
Knee Joint - anatomy & histology
Abstract
This volume presents detailed information on surgically relevant anatomy and histology of the anterior cruciate ligament (ACL), biomechanics, diagnostics, and ACL reconstruction. In light of the growing body of evidence demonstrating the advantages of anatomic ACL reconstruction over traditional methods, there are also discussions of single anteromedial bundle reconstruction and anatomic ACL reconstruction with abundant descriptions of experimental and clinical studies. In addition, particular attention is given not only to techniques such as ACL augmentation, bone-patella tendon-bone reconstruction and computer-assisted navigation, but it also presents expert analysis of revision of ACL reconstruction, complications, and the future perspectives of ACL reconstruction. Edited by authoritative orthopedic surgeon from the Japanese Orthopaedic Society of Knee, Arthroscopy and Sports Medicine (JOSKAS), this book provides up-to-date information for orthopedic surgeons and physical therapists specializing in the ACL. The research evidence will broaden readers' understanding and enable them to optimize outcomes for patients. As ACL rupture is a common injury especially for high-level athletes, it will also attract sports trainers and team physicians who are interested in a recent update on this field.
Contents
Part I. Anatomy and Histology of the ACL -- 1 Functional Anatomy of the ACL Fibers on the Femoral Attachment -- 2 The Anatomical Features of ACL Insertion Sites and Their Implications for Multi-Bundle Reconstruction -- 3 Discrepancy Between Macroscopic and Histological Observations -- 4 Tibial Insertion of the ACL: 3D-CT Images, Macroscopic, and Microscopic Findings -- 5 Mechanoreceptors in the ACL -- Part II. Biomechanics of the ACL -- 6 Mechanical Properties and Biomechanical Function of the ACL -- 7 Biomechanics of the Knee with Isolated One Bundle Tear of the Anterior Cruciate Ligament -- 8 Function and Biomechanics of ACL Remnant -- 9 Biomechanics of Single- and Double-Bundle ACL Reconstruction -- 10 ACL Injury Mechanisms -- Part III. Diagnostics of ACL Injury -- 11 Physical Examinations and Device Measurements for ACL Deficiency -- 12 Diagnostics of ACL Injury Using Magnetic Resonance Imaging (MRI) -- 13 Diagnosis of Injured ACL Using Three-Dimensional Computed Tomography: Usefulness for Preoperative Decision Making -- Part IV. Basic Knowledge of ACL Reconstruction -- 14 Graft Selection -- 15 Portal Placement -- 16 Femoral Bone Tunnel Placement -- 17 Tibial Bone Tunnel Placement in Double-Bundle Anterior Cruciate Ligament Reconstruction Using Hamstring Tendons -- 18 Tensioning and Fixation of the Graft -- 19 Tendon Regeneration after Harvest for ACL Reconstruction -- 20 Second-Look Arthroscopic Evaluation after ACL Reconstruction -- 21 Bone Tunnel Changes After ACL Reconstruction -- 22 Graft I impingement -- 23 Fixation Procedure -- Part V. Multiple bundle ACL Reconstruction -- 24 Single- vs. Double-Bundle ACL Reconstruction -- 25 Anatomic Double-Bundle Reconstruction Procedure -- 26 Triple-Bundle ACL Reconstruction with the Semitendinosus Tendon Graft -- Part VI. ACL Augmentation -- 27 History and Advantages of ACL Augmentation -- 28 Surgical Technique of ACL Augmentation -- Part VII. ACL Reconstruction Using Bone-Patella Tendon-Bone -- 29 An Overview -- 30 Anatomical Rectangular Tunnel ACL Reconstruction with a Bone-Patellar Tendon-Bone Graft -- 31 Rectangular vs. Round Tunnel -- Part VIII. Computer-Assisted Navigation in ACL Reconstruction -- 32 Intraoperative Biomechanical Evaluation Using a Navigation System -- 33 Application of Computer-Assisted Navigation -- Part IX. ACL Injury in Patients with Open Physes -- 34 ACL Reconstruction with Open Physes -- 35 Avulsion Fracture of the ACL -- Part X. Revision ACL Reconstruction -- 36 Double-Bundle Technique -- 37 Bone-Patellar Tendon-Bone Graft via Round Tunnel -- 38 Anatomical Revision ACL Reconstruction with Rectangular Tunnel Technique -- 39 One- vs. Two-Stage Revision Anterior Cruciate Ligament Reconstruction -- Part XI. Complications of ACL Reconstruction -- 40 Complications of ACL Reconstruction -- Part XII. Future of ACL Reconstruction -- 41 Future Challenges of Anterior Cruciate Ligament Reconstruction: Biological Modulation Using a Growth Factor Application for Enhancement of Graft Healing -- 42 Strategies to Enhance Biological Tendon-Bobe Healing in Anterior Cruciate Ligament Reconstruction -- 43 Tissue engineering approach for ACL healing.
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e-Book
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Online
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Acrodermatitis Enteropathica : A Clinician's Guide

https://libcat.nshealth.ca/en/permalink/provcat39294
Pooya Khan Mohammad Beigi, Emanual Maverakis. --Cham: Springer , c2015.
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Written by and for dermatologists, pediatric and obstetrics specialists. This book presents the groundbreaking work of Dr. Pooya Khan Mohammad Beigi M.D., whose clinical research study on Acrodermatitis Enteropathica (AE) is the largest ever conducted on this rare disorder. The only book of its kind to offer insights into AE, it not only includes dozens of high quality photographs, illustrations, and clinical tables, but also covers everything from the history of AE to categories of the disorde…
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Author
Khan Mohammad Beigi, Pooya
Other Authors
Maverakis, Emanual
Responsibility
Pooya Khan Mohammad Beigi, Emanual Maverakis
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xxi, 156 p. : 56 illus., 51 illus. in color)
ISBN
9783319178196
9783319178189 (print ed.)
Subjects (MeSH)
Acrodermatitis
Zinc - deficiency
Abstract
Written by and for dermatologists, pediatric and obstetrics specialists. This book presents the groundbreaking work of Dr. Pooya Khan Mohammad Beigi M.D., whose clinical research study on Acrodermatitis Enteropathica (AE) is the largest ever conducted on this rare disorder. The only book of its kind to offer insights into AE, it not only includes dozens of high quality photographs, illustrations, and clinical tables, but also covers everything from the history of AE to categories of the disorder, molecular analysis, epidemiology, disorder signs and symptoms, diagnosis, treatment, and more. Acrodermatitis Enteropathica is a rare disorder of zinc metabolism that occurs in one of two forms: inborn and acquired. If untreated, this disease is fatal and affected individuals may die within just a few years. Therefore, it is critical that physicians are aware of the signs and symptoms related to AE and the appropriate treatments available for patients.
Contents
[publisher supplied] 1. History of Acrodermatitis Enteropathica -- 2. Epidemiology and Etiology -- 2.1. Epidemiology -- 2.2. Etiology -- 2.2.1. Molecular Etiology of AE -- 2.2.2. Hypothetical Etiology 1: the Alteration of Zinc Bioavailability -- 2.2.3. Hypothetical Etiology 2: a Defective Zinc Transporter -- 2.2.4. Alternative Forms of AE-like Zinc Deficiencies -- 3. Analysis of Disorder -- 3.1. Clinical Forms of AE -- 3.2. Nomenclature of Zinc Deficiencies -- 3.3. Acquired Non-hereditary Zinc Deficiency -- 3.3.1. Zinc Deficient Maternal Breast Milk -- 3.3.2. Zinc Deficient Caused by Metabolism Disorders -- 4. Clinical Symptoms -- 5. Diagnosis -- 5.1. Laboratory Diagnosis of Zinc Deficiency -- 5.2. Histopathology -- 5.3. Biological Diagnosis of AE -- 5.4. Clinical Diagnosis -- 5.5. Molecular Diagnosis -- 5.6. Differential Diagnosis -- 6. Disease Course and Treatment -- 6.1. Treatment -- 7. The Role of Zinc in Different Body Systems -- 7.1. Biochemistry of Zinc Metabolism -- 7.2. Skin and Hair Physiology -- 7.3. Gastrointestinal System and Other Organs -- 7.4. Neurological Development, Growth, and Mental Status -- 7.5. Enzymes -- 7.6. Endocrine System -- 7.7. Metabolism of Nucleic Acids -- 7.8. Mitosis and Meiosis Cycles -- 7.9. Cell Membranes -- 7.10. Synthesis of Proteins and Collagen -- 7.11. Immune System -- 8. History of AE in Adults -- 9. Iranian Hospital Cases in Literature -- 9.1. Patient One -- 9.2. Patient Two -- 9.3. Patient Three -- 9.4. Patient Four -- 9.5. Zinc Deficiency Similarities to AE in Infants (Fifth Patient) -- 10. Clinical Research -- 10.1. Abstract -- 10.2. Synopsis of Study -- 10.3. Purpose of Study -- 10.4. The Considered Hypotheses -- 10.5. Introduction -- 10.5. Methods -- 10.6. Ethical Considerations -- 10.7. Results -- 10.8. Discussion -- 11. Evaluation of Symptoms in Razi Dermatology Hospital -- 12. Case Photos.
Format
e-Book
Location
Online
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Adolescent substance abuse : research and clinical advances

https://libcat.nshealth.ca/en/permalink/provcat27240
edited by Howard A. Liddle, Cynthia L. Rowe. --Cambridge, UK: Cambridge University Press , 2006.
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Online
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Author
Liddle, Howard A
Other Authors
Rowe, Cynthia L
Responsibility
edited by Howard A. Liddle, Cynthia L. Rowe
Place of Publication
Cambridge, UK
Publisher
Cambridge University Press
Date of Publication
2006
Physical Description
509 p.
ISBN
6610347131
Subjects (MeSH)
Addiction Medicine - methods
Substance-Related Disorders - therapy - Adolescent
Contents
Cover -- Half-title -- Title -- Copyright -- Contents -- Contributors -- Forewords -- Foreword 1 -- Foreword 2 -- Acknowledgements -- Abbreviations -- 1 Treating adolescent substance abuse: state of the science -- A brief history of adolescent substance abuse treatment research -- Theoretical, empirical, and methodological foundations for research -- Practice and policy trends in treatment for adolescent substance abuse -- Comprehensive assessment and integrative treatment planning with adolescent substance abusers -- Empirically based interventions for adolescent substance abuse: research and practice implications -- Culturally based treatment development for adolescent substance abusers -- Next steps in adolescent substance abuse treatment research -- References -- Part I Theoretical, empirical, and methodological foundations for research into treatment of adolescent substance abuse -- 2 The developmental context for adolescent substance abuse intervention -- The developmental model -- The influence of each domain -- Interactions of individual, family, peer, and environmental factors -- Implications for prevention and treatment -- Conclusions -- Acknowledgements -- References -- 3 Recent methodological and statistical advances: a latent variable growth modeling framework -- A latent variable approach to growth curve modeling -- Typical approaches to studying change -- Toward an integrated developmental model -- Specification of the latent variable growth model -- Representing the shape of growth over time -- Including predictors and sequelae of change -- Multivariate and higher-order extensions -- Analyzing treatment effectiveness: modeling between-subjects effects -- Alternative approaches to analyzing treatment effects: interrupted time series models -- Incorporating effects of the social context: hierarchical or multilevel designs -- Modeling unobserved heterogeneity: treatment audience profiling -- Conclusions -- Summary -- Acknowledgements -- References -- 4 Clinical course of youth following treatment for alcohol and drug problems -- Adolescent relapse patterns following drug and alcohol treatment: treatment outcome studies -- The process of relapse for adolescents -- Factors that predict success for adolescents following drug and alcohol treatment -- Special challenges youth face in controlling drug and alcohol use after treatment -- Conclusions -- References -- 5 Cannabis Youth Treatment intervention: preliminary findings and implications -- Treatments and their rationale -- Overview of field trials -- Highlights of findings -- Implications and next steps -- References -- Part II Practice and policy trends in treatment for adolescent substance abuse -- 6 Epidemiological trends and clinical implications of adolescent substance abuse in Europe -- Prevalence of substance use -- Prevalence of substance abuse and dependence -- Summary -- Comorbidity and temporal sequences of disorders -- Risk factors -- Political implications of adolescent substance abuse: a response from the European Union -- Conclusions -- References -- 7 The Drug Abuse Treatment Outcomes Studies: outcomes with adolescent substance abusers -- Drug Abuse Reporting Program -- Treatment
Format
e-Book
Location
Online
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Advanced Imaging Techniques in Clinical Pathology

https://libcat.nshealth.ca/en/permalink/provcat39722
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors. --New York, NY: Springer New York : Imprint: Humana Press , c2016.
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This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet co…
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Other Authors
Sacerdoti, Francesco M
Giordano, Antonio
Cavaliere, Carlo
Responsibility
Francesco M. Sacerdoti, Antonio Giordano, Carlo Cavaliere, editors
Place of Publication
New York, NY
Publisher
Springer New York : Imprint: Humana Press
Date of Publication
c2016
Physical Description
1 online resource (ix, 165 p. : 53 illus., 37 illus. in color)
Series Title
Current clinical pathology
ISBN
9781493934690
9781493934676 (print ed.)
ISSN
2197-781X
Subjects (MeSH)
Clinical Laboratory Techniques
Diagnostic Imaging
Pathology, Clinical - methods
Abstract
This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them. This textbook will serve as a very useful resource for physicians and researchers dealing with, and interested in, cell analysis. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. Advanced Imaging Techniques in Clinical Pathology will be of great value to clinical pathologists, biologists, biology researchers, and those working in the clinical and biological laboratory arena.
Contents
1 Introduction -- Part I. Basic Knowledge -- 2 Digital Image Processing -- 3 Statistical Analysis and Software -- Part II. Applications -- 4 Microscopy Techniques -- 5 Cytometry and Pathology -- 6 Advanced Imaging Techniques -- Part III. Diagnostic Imaging and Pathology -- 7 Diagnostic Imaging and Pathology -- 8 Preclinical Techniques in Animals -- 9 Preclinical Imaging: Experimental Example -- 10 Clinical Techniques in Humans -- 11 Clinical Imaging Experimental Example in Pathology -- 12 Ultrasound in the Evaluation of Cutaneous Diseases -- 13 Diagnostic Imaging Techniques: Lessons Learned -- Erratum to: Advanced Imaging Techniques in Clinical Pathology.
Format
e-Book
Location
Online
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Advanced Practice in Endocrinology Nursing

https://libcat.nshealth.ca/en/permalink/provcat44176
Sofia Llahana, Cecilia Follin, Christine Yedinak, Ashley Grossman, editors. --Cham: Springer , 2019.
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This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society for Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resourc…
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Other Authors
Llahana, Sofia
Follin, Cecilia
Yedinak, Christine
Grossman, Ashley
Other Authors
European Society for Endocrinology
Responsibility
Sofia Llahana, Cecilia Follin, Christine Yedinak, Ashley Grossman, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (xxxiii, 1337 p.) : 272 illus., 209 illus. in color
ISBN
9783319998176
9783319998152 (Print ed.)
9783319998169 (Print ed.)
Subjects (MeSH)
Endocrine Diseases - nursing
Specialty
Endocrinology
Nursing
Abstract
This book provides a comprehensive guide for nurses practicing in any area of endocrinology and at any level of expertise. Endocrinology Nursing is a fast-developing specialty with nurses performing advanced roles and expanding their practice to run independent nurse-led services. Supported by the European Society for Endocrinology (ESE) and edited by members of the ESE Nurses Working Group, this is the first book ever published specifically for endocrine nurses. It is also an excellent resource for endocrinology specialty trainees, general practitioners, medical and nursing students, expert patients and nurses working in specialties such as fertility, osteoporosis, oncology, obesity, urology and gynaecology, who look after patients with endocrine-related disorders. This volume includes 13 sections and 69 chapters providing a comprehensive overview of adult and paediatric endocrinology but also a section on advanced practice, role development and nursing research. It has been written by an international team of more than 100 eminent nurses, physicians, surgeons, psychologists and other healthcare professionals, which makes this book a valuable resource for any multidisciplinary team. Many patient advocacy groups have contributed with case studies which emphasises the close working relationships with patients.
Contents
Part I. Growth and Development -- Part II. Endocrine Disorders and Genetics in Childhood -- Part III. Hypothalamus and Pituitary -- Part IV. The Thyroid Gland -- Part V. The Adrenal Gland -- Part VI. Female Endocrinology and Reproduction -- Part VII. Male Endocrinology and Reproduction -- Part VIII. Parathyroid, Calcium and Bone Disorders -- Part IX. Obesity and Disorders of Lipid Metabolism -- Part X. Late Effects of Cancer Treatment in Relation to Endocrinology -- Part XI. Endocrine Emergencies -- Part XII. Neuroendocrine Tumours and Multiple Endocrine Neoplasia -- Part XIII. Advanced Practice Nursing in Endocrinology.
Format
e-Book
Location
Online
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Advances in Biology and Treatment of Glioblastoma

https://libcat.nshealth.ca/en/permalink/provcat41809
Kumaravel Somasundaram, editor. --Cham: Springer , 2017.
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This volume covers the most important areas of glioblastoma: surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.
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Other Authors
Somasundaram, Kumaravel
Responsibility
Kumaravel Somasundaram, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (ix, 272 pages) : 24 illus. in color
Series Title
Current cancer research
ISBN
9783319568201
9783319568195 (print ed.)
ISSN
2199-2584
Subjects (MeSH)
Glioblastoma - pathology
Neurosurgical Procedures - methods
Abstract
This volume covers the most important areas of glioblastoma: surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatric glioblastoma. Chapter authors are junior and senior investigators, who are well established in their particular areas and include neurosurgeons, neuropathologists, neurooncologists and basic scientists.
Contents
1. Maximal Safe Resection in Glioblastoma: Use of Adjuncts -- 2. Molecular Pathology of Glioblastoma- an Update -- 3. Current Therapies and Future Directions in Treatment of Glioblastoma -- 4. Recent Advances for Targeted Therapies in Glioblastoma -- 5. Targeting EGFR in Glioblastoma: Molecular Biology and Current Understanding -- 6. Radiogenomics & Histomics in Glioblastoma: The Promise of Linking Image-derived Phenotype with Genomic Information -- 7. Next-generation Sequencing in Glioblastoma Personalized Therapy -- 8. Glioma Stem-like Cells in Tumor Growth and Therapy Resistance of Glioblastoma -- 9. Animal Models in Glioblastoma: Use in Biology and Developing Therapeutic Strategies -- 10. Pediatric High Grade Glioma.
Format
e-Book
Location
Online
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Advances in DNA repair in cancer therapy

https://libcat.nshealth.ca/en/permalink/provcat32399
Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors. --New York, NY: Springer , c2013.
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This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and dow…
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Other Authors
Panasci, Lawrence
Aloyz, Raquel
Alaoui-Jamali, Moulay
Responsibility
Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (viii, 312 p. : 35 ill., 25 ill. in color)
Series Vol.
72
Series Title
Cancer drug discovery and development
ISBN
9781461447412
Subjects (MeSH)
Antineoplastic Agents - therapeutic use
DNA Repair
Neoplasms - drug therapy
Neoplasms - genetics
Subjects (LCSH)
Oncology
Abstract
This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined.
Contents
Repair of DNA interstrand cross-links produced by cancer chemotherapeutic drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- Relationship between DNA-repair genes, cellular radiosensitivity, and the response of tumors annd normal tissues to radiotherapy -- Important roles of ERCCI in DNA repair and targeted therapy -- The role of BRCA1 and BRCA2 in anticancer drug therepy -- DNA-PK in CLL chemotherapy -- Poly (ADP) ribose polymerase at the interface of DNA damage signaling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a therapeutic target -- Telomores, Telomerase, and DNA damage response in cancer therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index.
Format
e-Book
Location
Online
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Advances in Nutrition and Cancer

https://libcat.nshealth.ca/en/permalink/provcat39632
Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione, editors. --Berlin, Heidelberg: Springer , c2014.
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This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed "nutrition and cancer" from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital inter…
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Other Authors
Zappia, Vincenzo
Panico, Salvatore
Russo, Gian Luigi
Budillon, Alfredo
Della Ragione, Fulvio
Other Authors
International Conference on Advances in Nutrition and Cancer (3rd : 2012 : Naples, Italy)
Responsibility
Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione, editors
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xiv, 460 p. : 59 illus., 34 illus. in color)
Series Vol.
159
Series Title
Cancer treatment and research
ISBN
9783642380075
9783642380068 (print ed.)
ISSN
0927-3042
Subjects (MeSH)
Feeding Behavior
Neoplasms - diet therapy
Neoplasms - etiology
Neoplasms - prevention & control
Abstract
This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed "nutrition and cancer" from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the "omics") that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions. Advances in Nutrition and Cancer will be an invaluable source of topical information for all researchers and clinicians with an interest in this field.
Contents
Part I: Life Style, Diet and Cancer -- The role of metabolic carcinogenesis in cancer causation and prevention: evidence from the European prospective investigation into cancer and nutrition -- Obesity, energy balance and cancer: a mechanistic perspective -- Fruits and vegetables. Updating the epidemiologic evidence for the WCRF-AICR lifestyle recommendations for cancer prevention -- The diet as a cause of human prostate cancer -- Mediterranean dietary pattern and chronic diseases -- Dietary salt intake and risk of gastric cancer -- Alcoholic beverages and carbonated soft drinks: consumption and gastrointestinal cancer risks -- Part II: Natural Dietary Molecules -- Anti-inflammatory and anti-cancer drugs from nature -- Selenium and cancer: a story that should not be forgotten--Insights from genomics -- Resveratrol: from basic studies to bedside -- Quercetin: a pleiotropic kinase inhibitor against cancer -- Sulforaphane as a promising molecule for fighting cancer -- Part III: Genetics and Epigenetics -- Functions, aberrations and advances for chromatin modulation in cancer -- Epigenetics and epidemiology: models of study and examples -- Dietary epigenetics in cancer and aging -- Breast cancer and the importance of early life nutrition -- Part IV: Olive Oil in Cancer Prevention -- Olive oil and other dietary lipids in breast cancer -- A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer -- Extra virgin olive oil: from composition to "molecular gastronomy" -- Part V: Life Style Prevention of Cancer -- Life style prevention of cancer recurrence: the yin and the yang -- Part VI: Emerging Breakthroughs -- New perspective for an old antidiabetic drug: metformin as anticancer agent -- Gut microbes, diet and cancer -- Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention -- Nutriomes and personalised nutrition for DNA damage prevention, telomere integrity maintenance and cancer growth control -- Novel approaches in melanoma prevention and therapy -- Concluding remarks.
Format
e-Book
Publication Type
Congress
Location
Online
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Alcohol use disorders and the lung : a clinical and pathophysiological approach

https://libcat.nshealth.ca/en/permalink/provcat33180
edited by David M. Guidot, Ashish J. Mehta. --New York, NY: Humana Press , c2014.
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Online
Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach is an excellent resource for clinicians who care for individuals affected by alcohol use disorders in diverse settings. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause acute lung injury. In parallel, these same pathophysiological effects of alcoho…
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Other Authors
Guidot, David M
Mehta, Ashish J
Responsibility
edited by David M. Guidot, Ashish J. Mehta
Place of Publication
New York, NY
Publisher
Humana Press
Date of Publication
c2014
Physical Description
1 online resource (x, 252 p.)
Series Vol.
14
Series Title
Respiratory medicine (New York, N.Y.)
ISBN
9781461488330 (electronic bk.)
Subjects (MeSH)
Alcohol Drinking - adverse effects
Alcohol-Related Disorders - complications
Lung Diseases
Subjects (LCSH)
Alcohol - Physiological effect
Alcoholism - Complications
Lungs - Diseases
Abstract
Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach is an excellent resource for clinicians who care for individuals affected by alcohol use disorders in diverse settings. Although alcohol abuse alone does not cause acute lung injury, it renders the lung susceptible to dysfunction in response to the inflammatory stresses of sepsis, trauma, and other clinical conditions recognized to cause acute lung injury. In parallel, these same pathophysiological effects of alcohol abuse significantly increase the risk of a wide range of serious lung infections. Many clinicians involved in the primary treatment of alcohol use disorders, such as addiction psychiatrists, will find this text of interest as it will expand their understanding of the health consequences of alcohol use disorders. In parallel, clinicians who specialize in pulmonary and/or critical care medicine will have a unique resource that provides a comprehensive review of the pathophysiology of alcohol-related lung disorders and insights into evolving therapeutic options in these vulnerable individuals. Alcohol Use Disorders and the Lung: A Clinical and Pathophysiological Approach fills a gap in the literature and presents the evolving clinical research that may soon lead to novel therapies that can improve lung health in individuals with alcohol use disorders and co-existing conditions such as HIV infection.
Contents
A Brief History of Alcohol Use and Abuse in Human History -- Overview of the Evolving Recognition of the Health Effects of Excessive Alcohol Use Over the Past Two Centuries Including the Classic Citations -- Current Definitions of Alcohol Use Disorders and the Use of Validated Questionnaires in Clinical Practice and Research -- The Epidemiology of Alcohol Abuse and Pneumonia -- The Epidemiology of Alcohol and Acute Respiratory Distress Syndrome -- Alcohol, the Upper Airway, and Mucociliary Dysfunction in the Conducting Airways -- Alcohol and the Alveolar Macrophage -- Alcohol and the Alveolar Epithelium -- Alcohol-Mediated Oxidative Stress in the Airway: The Unique Role of Thiol Depletion -- Alcohol and the Adaptive Immune Response in the Airway: Dendritic Cell and Lymphocyte Impairments -- Alcohol Impairment of Granulocyte Function During Lung Infection -- Disruption in the Dynamic Balance Between Transforming Growth Factor- and Granulocyte/Macrophage Colony-stimulating Factor Signaling within the Alveolar Space of the Alcoholic Lung: Impact on Epithelial and Macrophage Function -- Alcohol-mediated Zinc Deficiency within the Alveolar Space: A Potential Fundamental Mechanism Underlying Oxidative Stress and Cellular Dysfunction in the Alcoholic Lung -- The Impact of Alcohol Abuse on Multiple Organ Dysfunction in the Surgical Patient -- Alcohol and HIV: Experimental and Clinical Evidence of Combined Impact on the Lung -- Maternal Alcohol Use and the Neonate.
Format
e-Book
Location
Online
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ALERT – adverse late effects of cancer treatment. Volume 1, General concepts and specific precepts

https://libcat.nshealth.ca/en/permalink/provcat33390
Philip Rubin, Louis S. Constine, Lawrence B. Marks, editors. --Heidelberg: Springer , c2014.
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Location
Online
The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system different…
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Other Authors
Rubin, Philip
Constine, Louis S
Marks, Lawrence B
Responsibility
Philip Rubin, Louis S. Constine, Lawrence B. Marks, editors
Alternate Title
Adverse late effects of cancer treatment
Place of Publication
Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xxiv, 311 pages)
Series
Medical radiology. Radiation oncology
Series Title
Medical radiology (Series)
ISBN
9783540723141 (electronic bk.)
9783540723134
Subjects (MeSH)
Antineoplastic Agents - adverse effects
Radiotherapy - adverse effects
Radiation Injuries
Subjects (LCSH)
Cancer - Treatment - Complications
Antineoplastic Agents - adverse effects
Radiotherapy - adverse effects
Abstract
The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 1 of this two-volume work focuses on the general concepts and principles relevant to late effects and on the dynamic interplay of molecular, cytologic and histopathologic events that lead to altered physiologic and metabolic functions and their clinical manifestations. Chapters are also included on legal issues, economic aspects, nursing, psychological issues and quality of life.
Contents
Prologue: Surviving Cancer: SEER Statistics -- Biocontinuum of the Pathophysiology Paradigm -- Biophysiopathology of the Microvasculature and Microcirculation -- Molecular Mechanisms of Radiation Induced Injury -- Biodetection and Biointervention: Cytokine Pathways as a Rationale for Anti-Cytokine Interventions Post-Radiation -- Quantitative/Objective Analyses of RT-Induced Late Normal Tissue Injury Using Functional Imaging -- Biograding of Normal Tissue TNM Toxicity Taxonomy: Scoring the Adverse Effects of Cancer Treatment -- Understanding and Predicting Radiation-Associated Normal Tissue Injury: A Global and Historical Perspective -- Biotoxicity of Chemotherapy -- BioSurveillance and Longitudinal Lifelong Guidelines -- BioPediatric Complexities of Growth and Development -- BioGenetic and Host Implications -- Bioengineering of Irradiated Normal Tissues by Bone Marrow Stem Cells -- Radiotherapy-Induced Carcinogenesis and Leukemogenesis: Mechanisms and Quantitative Modeling -- The Bioepidemiology of MultiplePrimary Cancers -- Radiation-Related Second Primary Cancers: Clinical Perspectives -- The Psychosocial and Functional Impact of Radiation Therapy -- Nursing -- Economic Consequences of Late Effects -- Radiological and Nuclear Terrorism: Relevance to the Radiation Oncology and Biology Communities.
Format
e-Book
Location
Online
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Anatomical Variations in Clinical Dentistry

https://libcat.nshealth.ca/en/permalink/provcat44089
Joe Iwanaga, R. Shane Tubbs, editors. --Cham: Springer , 2019.
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Online
This excellently illustrated book aims to equip dentists, oral surgeons, and trainees with the detailed knowledge of anatomical variations in the oral region that is now required for optimal daily clinical practice. The book opens with an introductory section on anatomical variations from the point of view of different clinical practitioners – oral and maxillofacial surgeons, periodontists, and endodontists. The newest anatomical knowledge and variations are then presented in turn for the mandi…
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Other Authors
Iwanaga, Joe
Tubbs, R. Shane
Responsibility
Joe Iwanaga, R. Shane Tubbs, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 247 p.) : 150 illus., 131 illus. in color
ISBN
9783319979618
9783319979601 (Print ed.)
9783319979625 (Print ed.)
Subjects (MeSH)
Mouth - anatomy & histology
Mouth - growth & development
Mouth Abnormalities
Odontogenesis
Specialty
Anatomy
Dentistry
Abstract
This excellently illustrated book aims to equip dentists, oral surgeons, and trainees with the detailed knowledge of anatomical variations in the oral region that is now required for optimal daily clinical practice. The book opens with an introductory section on anatomical variations from the point of view of different clinical practitioners – oral and maxillofacial surgeons, periodontists, and endodontists. The newest anatomical knowledge and variations are then presented in turn for the mandible, maxillary sinus, hard palate, floor of the mouth, lips, temporomandibular joint, and teeth. In each chapter, clinical annotations are included in order to enhance understanding of the relationships between surgery and anatomy. The internationally renowned authors have been carefully selected for their expertise in the topics that they discuss. Anatomical Variations in Clinical Dentistry will be invaluable for general dentists, endodontists, periodontists, and implantologists and will also be an asset for anatomists, oral and maxillofacial surgeons, otolaryngologists, dental students, and dental hygienists.
Contents
Different Perspectives of Anatomical Variations in Dentistry: Anatomical Variations from the Point of View of Oral and Maxillofacial Surgeons -- Anatomical Variations from the Point of View of the Periodontist -- Anatomical Variations from the Point of View of the Endodontist. Mandible: Anatomy and Variations of the Pterygomandibular Space -- Anatomy and Variations of the Retromolar Fossa -- Anatomy and Variations of the Mental Foramen -- Variant Anatomy of the Mandibular Torus. Maxillary Sinus: Anatomy and Variations of the Floor of the Maxillary Sinus -- Anatomy and Variations of the Posterior Superior Alveolar Nerve/Artery. Hard Palate: Anatomy and Variations of the Greater Palatine Foramen -- Anatomy and Variations of the Incisive Foramen -- Variant Anatomy of the Torus Palatinus. Lingual Plate and Oral Floor: Anatomy and Variations of the Submandibular Fossa -- Anatomy and Variations of the Sublingual Space -- Anatomy and Variations of the Lingual Frenulum and Sublingual Surface. Lip: Anatomy and Variations of the Frenula of the Lips -- Anatomy and Variations of the Lips. Temporomandibular Joint: Anatomy and Variations of the Temporomandicular Joint. Teeth: Variations in the Number of Teeth -- Tooth Anatomy and Variants -- Abnormal Tooth Eruption.
Format
e-Book
Location
Online
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Anesthetic Management for the Pediatric Airway : Advanced Approaches and Techniques

https://libcat.nshealth.ca/en/permalink/provcat44212
Diego Preciado, Susan Verghese, editors. --Cham: Springer , 2019.
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Location
Online
The advancement of tactics used in managing pediatric airway disorders can be attributed to an overall growth of collective knowledge among medical health professionals. This book is designed to sustain that growth of knowledge, with 18 chapters of insight and information by distinguished medical experts in both pediatric anesthesia and pediatric otolaryngology. It concisely and thoroughly covers topics such as subglottic stenosis, pharyngeal airway obstruction, laryngeal airway obstruction, ob…
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Other Authors
Preciado, Diego
Verghese, Susan
Responsibility
Diego Preciado, Susan Verghese, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (xvi, 206 p.) : 34 illus., 26 illus. in color
ISBN
9783030046002
9783030045999 (Print ed.)
9783030046019 (Print ed.)
Subjects (MeSH)
Airway Management
Anesthesia - methods
Child
Infant
Specialty
Anesthesiology
Pediatrics
Abstract
The advancement of tactics used in managing pediatric airway disorders can be attributed to an overall growth of collective knowledge among medical health professionals. This book is designed to sustain that growth of knowledge, with 18 chapters of insight and information by distinguished medical experts in both pediatric anesthesia and pediatric otolaryngology. It concisely and thoroughly covers topics such as subglottic stenosis, pharyngeal airway obstruction, laryngeal airway obstruction, obesity and sleep apnea and thoracic airway obstruction, among others. Chapters include scenarios where the skills and expertise of both anesthesiologists and otolaryngologists are being continually tested; the use of newer drugs and repurposing of older drugs; the combination of smaller amounts of different types of sedatives while avoiding intra-op narcotics and maintaining spontaneous ventilation are described in detail; Finally, a comprehensive review of new research emerging about ultra-rapid narcotics metabolizers among patients, making them more susceptible to medications, such as codeine, along with the latest information on the purported potential neurodevelopmental toxicity of some anesthetic agents are also included. Working as both an educational tool and a practical resource, medical practitioners, students and educators will find this text to be a valuable tool for the safely managing the pediatric patient undergoing anesthesia for difficult airway scenarios.
Contents
1. Evolution of Anesthesia for Pediatric Airway Surgery: From Ether to TIVA and Current Controversies -- 2. Preop Considerations in the Evaluation of Children with Airway Pathologies -- 3. Airway Pathologies Requiring Specialized Pediatric Anesthesia -- 4. Preferred Anesthesia for Routine Otolaryngologic Procedures -- 5. Anesthesia Methods for Airway Endoscopy -- 6. Neonatal Laryngoscopy and Bronchoscopy -- 7. Difficult Airway Management of Neonates, Infants, and Children with Syndromes Involving the Airway -- 8. Anesthesia Maintenance During Endoscopic Airway Surgery -- 9. Anesthesia Maintenance During Open Airway Reconstruction -- 10. Optimal Sedation Protocol After Single-Stage Open Airway Reconstruction -- 11. Anesthetic Management in Emergent Pediatric Foreign Bodies -- 12. Anesthetic and Reconstructive Considerations in Major Head and Neck Trauma -- 13. Anesthetic Management of Morbidly Obese Patients Undergoing Airway Surgery -- 14. Extracorporeal Membrane Oxygenation (ECMO) Considerations in Fulminant Airway Obstruction -- 15. Prevention Airway Complications During Aerodigestive Surgery -- 16. Management of Immediate Postoperative Airway Events in Children -- 17. Opioid Metabolism, Variability, and Overdose Management in Pediatric Airway Patients -- 18. ENT Surgery and Anesthesia Neurotoxicity in Children.
Format
e-Book
Location
Online
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Antiangiogenic Agents in Cancer Therapy

https://libcat.nshealth.ca/en/permalink/provcat40632
edited by Beverly A. Teicher, Lee M. Ellis. (2nd ed.) --Totowa, NJ: Humana Press , c2008.
Available Online
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Location
Online
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art…
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Other Authors
Teicher, Beverly A
Ellis, Lee M
Responsibility
edited by Beverly A. Teicher, Lee M. Ellis
Edition
2nd ed.
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2008
Physical Description
1 online resource (xviii, 559 p. : ill.)
Series Title
Cancer drug discovery and development
ISBN
9781597451840
9781588298706 (print ed.)
Subjects (MeSH)
Angiogenesis Inhibitors - therapeutic use
Antineoplastic Agents - therapeutic use
Neoplasms - drug therapy
Neovascularization, pathologic - drug therapy
Abstract
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Contents
Part I. Basic Biology of Angiogenesis -- Vascular Endothelial Growth Factor Family and Its Receptors -- The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors -- The Role of Integrins in Tumor Angiogenesis -- Tumor Endothelial Cell Abnormalities -- The Extracellular Matrix and VEGF Processing -- Endothelial Precursor Cells -- Role of Pericytes in Angiogenesis -- Newer Vascular Targets -- Chemokines in Angiogenesis -- Angiopoietin/Tie2 Signaling Regulates Tumor Angiogenesis -- Imaging Angiogenesis -- Tumor Blood Vessels -- Lymphatic System in the Pathology of Cancer -- Part II. Translational Research in Tumor Angiogenesis -- VEGF in the Adult -- Normalization of Tumor Vasculature and Microenvironment -- Metronomic Low-Dose Antiangiogenic Chemotherapy in Mice and Man -- Small-Molecule Vascular Disrupting Agents in Cancer Therapy -- Normalization of Tumor Vasculature and Improvement of Radiation Response by Antiangiogenic Agents -- Challenges in Translating Antiangiogenic Therapy from the Bench to Bedside -- Regulation of Angiogenesis in Cancer and Its Therapeutic Implications -- Part III. Antiangiogenic Therapy in the Clinical Trial Results and Future Directions -- Angiogenesis and Angiogenesis Inhibition in Sarcomas -- Antiangiogenesis Agents in Colorectal Cancer -- Antiangiogenic Therapy for Primary CNS Tumors -- Angiogenesis Inhibitors for the Treatment of Lung Cancer -- Antiangiogenic Therapy of Renal Cell Carcinoma -- Antiangiogenesis Therapies in Gynecologic Malignancies -- Antiangiogenic Agents in Myeloid Malignancies -- Angiogenesis in Malignant and Non-Malignant Pediatric Tumors -- Prognostic and Predictive Significance of Surrogate Biomarkers of Angiogenesis -- Endpoints for the Determination of Efficacy of Antiangiogenic Agents in Clinical Trials -- The Role of Imaging in the Clinical Development of Antiangiogenic Agents.
Format
e-Book
Location
Online
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Anti-Angiogenic Therapy in Ophthalmology

https://libcat.nshealth.ca/en/permalink/provcat39946
Andreas Stahl, editor. --Cham: Springer , c2016.
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Location
Online
This book provides a concise overview over the pathology of retinal angiogenic diseases and explains why anti-angiogenic therapy is effective in so many patients. The reader is guided through the various clinical indications for anti-angiogenic therapy and made aware of its merits as well as current challenges and limitations. It is explained how, since its introduction for the treatment of exudative age-related macular degeneration in 2006, anti-angiogenic therapy has revolutionized the way in…
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Other Authors
Stahl, Andreas
Responsibility
Andreas Stahl, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (x, 193 p. : 26 illus., 23 illus. in color)
Series Title
Essentials in ophthalmology
ISBN
9783319240978
9783319240954 (print ed.)
ISSN
1612-3212
Subjects (MeSH)
Angiogenesis Inhibitors - therapeutic use
Retinal Diseases - therapy
Abstract
This book provides a concise overview over the pathology of retinal angiogenic diseases and explains why anti-angiogenic therapy is effective in so many patients. The reader is guided through the various clinical indications for anti-angiogenic therapy and made aware of its merits as well as current challenges and limitations. It is explained how, since its introduction for the treatment of exudative age-related macular degeneration in 2006, anti-angiogenic therapy has revolutionized the way in which we treat a range of ocular diseases. All of the authors are established experts in their respective fields who share their extensive knowledge and clinical experience with the reader. This book is both a valuable introduction to anti-angiogenic therapy in ophthalmology and a day-to-day companion for all ophthalmologists seeing patients with some of the most prevalent retinal diseases.
Contents
Retinal Vascular Development -- Retinopathy of Prematurity -- Anti-Vascular Endothelial Growth Factor (VEGF) Treatment in Neovascular Age-Related Macular Degeneration: Outcomes and Outcome Predictors -- AREDS Supplementation and the Progression Towards Neovascular Exudative AMD -- VEGF-Inhibition in Macular Telangiectasia Type 2 -- Diabetic Retinopathy -- Retinal Vein Occlusion -- Pharmacokinetics of Intravitreally Applied VEGF Inhibitors -- Neovascular Glaucoma -- Corneal Neovascular Diseases -- Anti-Angiogenic Gene Therapy: Basic Science and Challenges for Translation into the Clinic.
Format
e-Book
Location
Online
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Articular Cartilage of the Knee : Health, Disease and Therapy

https://libcat.nshealth.ca/en/permalink/provcat45489
Harpal K. Gahunia, Allan E. Gross, Kenneth P.H. Pritzker, Paul S. Babyn, Lucas Murnaghan, editors. --New York, NY: Springer , c2020.
Available Online
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Location
Online
Covering both pediatric and adult populations, this comprehensive text covers the diverse topics related to the health, disease and therapy of articular cartilage of the knee, from basic principles to future directions for research. This vast array of information is arranged into eight sections, encompassing a number of relevant disciplines and covering, in turn, normal articular cartilage, aging and degeneration, evaluation and assessment, non-surgical approaches, surgical approaches, qualitat…
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Other Authors
Gahunia, Harpal K.
Gross, Allan E.
Pritzker, Kenneth P.H.
Babyn, Paul S.
Murnaghan, Lucas
Responsibility
Harpal K. Gahunia, Allan E. Gross, Kenneth P.H. Pritzker, Paul S. Babyn, Lucas Murnaghan, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxxviii, 498 p.) : 145 illus., 85 illus. in color
ISBN
9781493975877
9781493975853 (Print ed.)
9781493975860 (Print ed.)
Subjects (MeSH)
Cartilage, Articular - physiology
Knee Joint - physiology
Knee Joint - surgery
Specialty
Orthopedics
Abstract
Covering both pediatric and adult populations, this comprehensive text covers the diverse topics related to the health, disease and therapy of articular cartilage of the knee, from basic principles to future directions for research. This vast array of information is arranged into eight sections, encompassing a number of relevant disciplines and covering, in turn, normal articular cartilage, aging and degeneration, evaluation and assessment, non-surgical approaches, surgical approaches, qualitative and quantitative assessment of repair, research into cartilage repair and engineering, and future prospects for therapy. Each chapter is amply referenced and self-contained for independent study and reference. Scoring systems for knee cartilage assessment are included in four appendices as well, rounding out the presentation. A multidisciplinary collection of basic, translational and clinical material, Articular Cartilage of the Knee is a singular resource for orthopedic surgeons, rheumatologists, pathologists, scientists, tissue engineers and the broad spectrum of clinical professionals working with articular cartilage and its disorders.
Contents
Part I. Normal Articular Cartilage -- Structure and Function of Articular Cartilage -- Growth and Development of Articular Cartilage -- Part II. Aging, Degeneration and Physiologic Articular Cartilage Healing -- Articular Cartilage: Homeostasis, Aging and Degeneration -- Articular Cartilage Degradation: Biochemical Markers and Dynamic Loading -- Part III. Knee Articular Cartilage Injury: Evaluation and Assessment -- Acute and Chronic Traumatic Cartilage Injuries of the Knee -- Diagnostic Imaging of Knee Cartilage Injury: Evaluation and Assessment -- Assessment of Knee Cartilage Injury: Arthroscopic Evaluation and Classification -- Part IV. Repair of Knee Articular Cartilage Injury: Non-Operative Approach -- Physical and Rehabilitative Therapy for Knee Cartilage Injury and Disease -- Pharmacologic Agents for Knee Articular Cartilage Injury and Disease -- Part V. Repair of Knee Articular Cartilage: Surgical Approach -- Osteochondritis Dissecans of the Knee: Pathophysiology and Treatment -- Surgical Approach to Articular Cartilage Repair -- Clinical Outcome Assessment of Repaired Articular Cartilage -- Part VI. Qualitative and Quantitative Assessment of Articular Cartilage Repair -- Pre- and Post-Operative Imaging of Knee Articular Cartilage -- MRI of the Ultrastructural Composition of Articular Cartilage in Disease and Repair -- Histopathological Evaluation of Articular Cartilage Disease and Repair -- Part VII. Research in Cartilage Repair and Cartilage Engineering Strategies -- Human Derived Cells in Chondral or Osteochondral Repair -- Relevance of Engineered Scaffolds for Cartilage Repair -- Commercially Available Bio-Engineered Cartilage Grafts -- Part VIII. Future Prospects for Knee Articular Cartilage Therapy -- Knee Articular Cartilage: Future Directions for Research and Practice.
Format
e-Book
Location
Online
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ASPEN pediatric nutrition support core curriculum

https://libcat.nshealth.ca/en/permalink/provcat42381
editor in chief Mark R. Corkins. (2nd ed.) --Silver Spring, MD: American Society for Parenteral and Enteral Nutrition , c2015.
Available Online
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Location
Online
The A.S.P.E.N. Pediatric Nutrition Support Core Curriculum (2nd Ed) focuses on the pediatric patient and the importance of nutrition to the growth and development of children. Written with an interdisciplinary evidence-based approach, it is designed to meet the educational needs of any discipline involved in the nutrition care of pediatric patients. This edition features 37 fully revised and updated chapters and is designed to logically progress from the basic nutrition physiology and changes …
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Corporate Author
American Society for Parenteral and Enteral Nutrition
Other Authors
Corkins, Mark R.
Responsibility
editor in chief Mark R. Corkins
Edition
2nd ed.
Alternate Title
A.S.P.E.N. pediatric nutrition support core curriculum
ASPEN paediatric nutrition support core curriculum
Place of Publication
Silver Spring, MD
Publisher
American Society for Parenteral and Enteral Nutrition
Date of Publication
c2015
ISBN
9781889622224
Subjects (MeSH)
Enteral Nutrition
Nutritional Physiological Phenomena
Parenteral Nutrition
Abstract
The A.S.P.E.N. Pediatric Nutrition Support Core Curriculum (2nd Ed) focuses on the pediatric patient and the importance of nutrition to the growth and development of children. Written with an interdisciplinary evidence-based approach, it is designed to meet the educational needs of any discipline involved in the nutrition care of pediatric patients. This edition features 37 fully revised and updated chapters and is designed to logically progress from the basic nutrition physiology and changes that occur during development to the skills needed to provide appropriate nutrition for pediatric patients.
Format
e-Book
Location
Online
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Atherosclerosis Pathogenesis and Microvascular Dysfunction

https://libcat.nshealth.ca/en/permalink/provcat44655
Axel Haverich, Erin Colleen Boyle. --Cham: Springer , c2019.
Available Online
View e-Book
Location
Online
This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors, the effect of growth and aging on vascular architecture, and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well …
Available Online
View e-Book
Author
Haverich, Axel
Other Authors
Boyle, Erin Colleen
Responsibility
Axel Haverich, Erin Colleen Boyle
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (x, 130 p.) : 18 illus., 15 illus. in color
ISBN
9783030202453
9783030202446 (Print ed.)
9783030202460 (Print ed.)
9783030202477 (Print ed.)
Subjects (MeSH)
Atherosclerosis - physiopathology
Microvessels - physiopathology
Specialty
Cardiology
Pathology
Abstract
This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors, the effect of growth and aging on vascular architecture, and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well as for aortic and peripheral artery dissection. When seen through this lens, novel preventive and therapeutic opportunities can be envisioned. Atherosclerosis Pathogenesis and Microvascular Dysfunction proposes a single unifying mechanism of atherosclerosis development and describes potential preventative and therapeutic avenues based on this concept. It therefore represents a timely and valuable resource for internal medicine, cardiology, angiology cardiovascular surgeons, pathology clinicians, researchers, trainees, and students.
Contents
Introduction -- Atherosclerosis Risk Factors -- The Effect Of Growth And Aging On Vascular Architecture -- Incriminating Evidence For The Role Of The Microvasculature In Atherosclerosis -- Risk Factors And Prevention In Light Of Atherosclerosis Being A Microvascular Disease -- New Ways To Target Vasa Vasorum For The Prevention And Treatment Of Atherosclerosis -- Supporting Microvasculature Function.
Format
e-Book
Location
Online
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