Anaesthesia, Pharmacology, Intensive Care and Emergency Medicine A.P.I.C.E. : Proceedings of the 23rd Postgraduate Course in Critical Care Medicine Catania, Italy : November 5-7, 2010
https://libcat.nshealth.ca/en/permalink/provcat30800
Antonino Gullo (ed.).
--Milan:
Springer
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Gullo, Antonino
- Responsibility
- Antonino Gullo (ed.)
- Alternate Title
- APICE 23
- Former Title
- Anesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.
- Place of Publication
- Milan
- Publisher
- Springer
- Date of Publication
- c2011
- Physical Description
- 1 online resource (380 p.)
- ISBN
- 9788847020146
- Subjects (MeSH)
- Anesthesia - methods
- Critical Care - methods
- Pain - drug therapy
- Critical Care
- Emergency Medicine
- Critical Care - Congresses
- Subjects (LCSH)
- Anesthesiology
- Critical care medicine
- Contents
- Continuing Medical Education: Can I Think what I Read? -- Clinical Pharmacology: Pharmacological Manipulation in ICU. Kidney: Renal Injury. Ventilation: Adult and Paediatric:Respiratory Mechanics: Principles, Utility and Advances. Capnometry/Capnography in Prehospital Cardiopulmonary Resuscitation. Weaning from Mechanical Ventilation. Ventilatory Strategies in Acute Lung Injury. Mechanical Ventilation beyond the PICU -Cardiovascular Monitoring: The NEXFIN Monitor A Totally Non-Invasive Cardiac Output Monitor. Doppler Echocardiography in ICU Patients: Does It Improve Outcome? -- Management of Cardiac Arrest:Mild Therapeutic Hypothermia after Cardiac Arrest. Nasopharyngeal Cooling during Cardiopulmonary Resuscitation. Amplitude Spectrum Area as a Predictor of Successful Defibrillation Advances in Experimental and Clinical Research: Physiopathology and Severity of Post-Resuscitation Myocardial Dysfunction: Effects of Sodium-Hydrogen Exchanger Isoform-1 (NHE-1) Inhibitors and Erythropoietin. Experimental Treatment for Preservation of Mechanically Competent Cardiac Activity following Cardiac Arrest. Erythropoietin Facilitates Return of Spontaneous Circulation and Survival in Victims of Out-of-Hospital Cardiac Arrest -- Infections, Sepsis and Organ Dysfunction: Pathophysiology of Resistance amongst Aerobic Gram-negative Bacilli in Particular Acinetobacter Species. What Have we Learned from the Surviving Sepsis Campaign? Source Control. Immunoglobulins in Sepsis. Extracorporeal Endotoxin Removal in Sepsis. Perioperative Medicine: Perioperative Medicine An Introduction. Neuraxial Analgesia for Caesarean and Vaginal Delivery and Childhood Learning Disabilities. Off-label Drugs in Perioperative Medicine: Clonidine. Spinal Cord Stimulation. Cost Effectiveness of Spinal Cord Stimulation in Management of Severe Angina. Spinal Cord Stimulation:Clinical Assessment and Diagnostic Procedures in Neurotrauma. Disaster Medicine: Disaster Preparedness. Medical Emergency Response in Toxicological Mass Casualty. Quality of Care: Telemedicine to Improve Care in the Critically Ill. Professionalism, Quality of Care and Pay-for-Performance Services.
- Format
- e-Book
- Location
- Online
Biologics for the Treatment of Rheumatoid Arthritis
https://libcat.nshealth.ca/en/permalink/provcat39756
Ronald F van Vollenhoven.
(1st ed.)
--Cham:
Springer International Publishing : Imprint: Adis
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive overview of the available biologic therapies whilst comparing them to standard disease modifying anti-rheumatic drugs, and discusses how best to determine which therapy is most appropriate for an individual patient in the framework of current guidelines. Biologics for the Treatment of Rheumatoid Arthritis is an up-to-date and concise practical guide to the latest therapeutic developments in this field. This book is an invaluable source of topical information f…
- Available Online
- View e-Book
- Author
- van Vollenhoven, Ronald F
- Responsibility
- Ronald F van Vollenhoven
- Edition
- 1st ed.
- Place of Publication
- Cham
- Publisher
- Springer International Publishing : Imprint: Adis
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xiii, 132 p. : 40 illus., 37 illus. in color)
- ISBN
- 9783319131085
- 9783319131078 (print ed.)
- Subjects (MeSH)
- Antirheumatic Agents
- Arthritis, Rheumatoid - drug therapy
- Biological Products
- Immunoglobulins
- Abstract
- This book provides a comprehensive overview of the available biologic therapies whilst comparing them to standard disease modifying anti-rheumatic drugs, and discusses how best to determine which therapy is most appropriate for an individual patient in the framework of current guidelines. Biologics for the Treatment of Rheumatoid Arthritis is an up-to-date and concise practical guide to the latest therapeutic developments in this field. This book is an invaluable source of topical information for all rheumatologists and health care professionals treating patients with rheumatoid arthritis.
- Contents
- Disease overview -- General treatment aspects -- Overview of biologic therapies -- Cytokine inhibitors -- B-cell directed therapy -- T-cell directed therapy -- Novel biologics and small molecules with biologic-like effects -- Strategies for the optimal use of biologic agents in rheumatoid arthritis -- Considerations for special patient populations -- Conclusions and future outlook.
- Format
- e-Book
- Location
- Online
Cerebrospinal Fluid in Clinical Neurology
https://libcat.nshealth.ca/en/permalink/provcat39045
Florian Deisenhammer, Finn Sellebjerg, Charlotte E Teunissen, Hayrettin Tumani, editors.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identif…
- Available Online
- View e-Book
- Responsibility
- Florian Deisenhammer, Finn Sellebjerg, Charlotte E Teunissen, Hayrettin Tumani, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xiv, 441 p. : 75 illus., 51 illus. in color)
- ISBN
- 9783319012254
- 9783319012247 (print ed.)
- Abstract
- The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.
- Contents
- Part I. Basic Aspects of the Cerebrospinal Fluid -- 1 The History of Cerebrospinal Fluid -- 2 Anatomy of CSF-Related Spaces and Barriers Between Blood, CSF, and Brain -- 3 Physiology and Constituents of CSF -- 4 Techniques, Contraindications, and Complications of CSF Collection Procedures -- 5 Importance of Pre-analytical Stability for CSF Biomarker Testing -- Part II. Methods of CSF Analyses -- 6 Cell Count and Staining -- 7 Glucose and Lactate -- 8 CSF Total Protein -- 9 CSF Albumin: Albumin CSF/Serum Ratio (Marker for Blood-CSF Barrier Function) -- 10 Immunoglobulins in Cerebrospinal Fluid -- 11 Detection of Infectious Agents -- 12 Immunohistochemistry -- Part III. CSF in Clinical Syndromes -- 14 Acute Infectious Diseases -- 15 Chronic Infectious Inflammatory Diseases of the Central Nervous System -- 16 Autoimmune Encephalitis -- 17 Chronic Noninfectious Inflammatory CNS Diseases -- 18 CSF Findings in Guillain-Barré Syndrome: Demyelinating and Axonal Acute Inflammatory Polyneuropathies -- 19 Alterations of the Cerebrospinal Fluid in Chronic Inflammatory Diseases of the Peripheral Nervous System -- 20 Alzheimer’s Disease and Other Neurodegenerative Disorders -- 21 Paraneoplastic Neurological Syndromes -- 22 Laboratory Diagnosis of Subarachnoid Haemorrhage -- 23 CSF-orrhoea -- 24 Guidelines on Cerebrospinal Fluid Analysis.
- Format
- e-Book
- Location
- Online
Clinical and Basic Immunodermatology
https://libcat.nshealth.ca/en/permalink/provcat41299
Anthony A. Gaspari, Stephen K. Tyring, Daniel H. Kaplan, editors.
(Second edition)
--Cham:
Springer
, 2017.
- Available Online
- View e-Book
- Location
- Online
This book is an in-depth and user-friendly reference for better understanding immune-mediated skin diseases and their therapies. The focus is on the needs of the physician, resident, or student to understand the pathophysiology of the disease as well as the mechanisms of action of the therapies. Clinical and Basic Immunodermatology, Second Edition is an effective teaching tool that has practical applications for use on a daily basis. It is a valuable resource for practicing dermatologists, derm…
- Available Online
- View e-Book
- Other Authors
- Gaspari, Anthony A
- Tyring, Stephen K
- Kaplan, Daniel H
- Responsibility
- Anthony A. Gaspari, Stephen K. Tyring, Daniel H. Kaplan, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2017
- Physical Description
- 1 online resource (xvi, 895 pages) : 183 illus., 172 illus. in color
- ISBN
- 9783319297859
- 9783319297835 (print ed.)
- Abstract
- This book is an in-depth and user-friendly reference for better understanding immune-mediated skin diseases and their therapies. The focus is on the needs of the physician, resident, or student to understand the pathophysiology of the disease as well as the mechanisms of action of the therapies. Clinical and Basic Immunodermatology, Second Edition is an effective teaching tool that has practical applications for use on a daily basis. It is a valuable resource for practicing dermatologists, dermatology residents and students, and healthcare workers in related fields.
- Contents
- Concepts of Fundamental Importance for Understanding Skin Disease -- Cytokines and Chemokines -- Innate and Adaptive Immunity -- Neuroimmunology -- Stress and Immunity -- Toll-Like Receptors -- Conventional and Unconventional T Cells -- Complement System -- Cutaneous Dendritic Cells in Health and Disease -- Antimicrobial Peptides -- Photoimmunology -- Angiogenesis for the Clinician -- Common Skin Diseases -- Contact Dermatitis: Allergic and Irritant -- Atopic Dermatitis -- Psoriasis -- The Immunology of Acne -- Nonmelanoma Skin Cancer -- Immunobiology and Immune-Based Therapies of Melanoma -- Drug Eruptions -- Cutaneous Vasculitis -- Immunodermatology and Viral Skin Infection -- HIV Disease and AIDS -- Bacterial Infections -- Parasitic Infections -- Fungal Infections -- Cutaneous T-Cell Lymphoma -- Graft-Versus-Host Disease -- Allergic Urticaria -- Immunopharmacology -- Biologic Therapies for Inflammatory Disease -- Topical Immune Response Modifiers: Adjuvants -- Topical Immune Response Modifiers: Antiinflammatories -- Traditional Immune-Modulating Drugs -- Topical Corticosteroids -- Vaccines -- Intravenous Immunoglobulins -- Autoimmunity, Immunodeficiency, and Immune Çö Associated Dermatoses -- Novel Approach to the Evaluation of Primary Immunodeficiencies -- Iatrogenic Immunodeficiency and Skin Disease -- Granulomatosis -- Vitiligo Vulgaris -- Alopecia Areata -- Cutaneous Lupus Erythematosus -- Fibrotic Skin Diseases -- Pemphigus Family of Diseases -- The Pemphigoid Spectrum -- Epidermolysis Bullosa Acquisita -- Immunoglobulin A Dermatoses.
- Format
- e-Book
- Location
- Online
Comprehensive Biochemistry for Dentistry : Textbook for Dental Students
https://libcat.nshealth.ca/en/permalink/provcat44220
Anil Gupta.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitam…
- Available Online
- View e-Book
- Author
- Gupta, Anil
- Responsibility
- Anil Gupta
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xxxv, 604 p.) : 266 illus., 195 illus. in color
- ISBN
- 9789811310355
- 9789811310348 (Print ed.)
- 9789811310362 (Print ed.)
- Subjects (MeSH)
- Biochemical Phenomena
- Dentistry - education
- Specialty
- Biochemistry
- Dentistry
- Abstract
- This book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitamins and hormones, enriched with flow charts and diagrams for easy understanding and quick reference. It includes chapters on nucleic acids, nutrition and serum enzymes and organ function tests, and offers an innovative approach to familiarize dental students with the biochemical composition of enamel, dentine, cementum and saliva, explaining the biochemical basis of dental caries, periodontal diseases, role of fluorides in caries prophylaxis, fluoride toxicity, and the role of amino acids as anti-hypersensitive agents.
- Contents
- Introduction to Biochemistry -- Part I. Cellular Biochemistry -- Cell and Organelles -- Part II. Structural Biochemistry -- Proteins and Amino acids -- Plasma Proteins -- Haemoglobin -- Carbohydrates -- Lipids -- Nucleic Acids -- Enzymes -- Hormones -- Vitamins -- Part III. Metabolism -- Digestion and Absorption of Proteins -- Metabolism of Proteins and Amino acids -- Digestion and Absorption of Carbohydrates -- Metabolism of Carbohydrates -- Digestion and Absorption of Lipids -- Metabolism of Lipids -- Metabolism of Minerals -- Biological Oxidation -- Part IV. Medical Biochemistry -- Acid-Base Balance -- Nutrition -- Serum Enzymes and Organ Function Tests -- Part: V Immunochemistry -- Immunoglobulins -- Part V. Dental Biochemistry -- Dental Biochemistry.
- Format
- e-Book
- Location
- Online
Giving Your Child Subcutaneous Immunoglobulin at Home
https://libcat.nshealth.ca/en/permalink/chpams38049
IWK. Infectious Disease / Immunology.
Halifax, NS:
IWK Health Centre
, 2021.
- Pamphlet Number
- PL-1237
- Available Online
- View Pamphlet
Part 1 outlines the program and criteria to which patients/families must adhere; Part 2 outlines troubleshooting ideas for: leaking at catheter site; local irritation (i.e. redness, swelling, itching; extreme discomfort with needle; blood return observed; long infusion times; needle contaminated by touching, dropping, etc.; infusion pump stops during infusion.
- Available Online
- View Pamphlet
- Corporate Author
- IWK. Infectious Disease / Immunology
- Alternate Title
- Information about the Home Subcutaneous Immunoglobulin (SCIg) Infusion Program
- How to Troubleshoot Infusion Problems at Home
- Place of Publication
- Halifax, NS
- Publisher
- IWK Health Centre
- Date of Publication
- 2021
- Format
- Pamphlet
- Language
- English
- Physical Description
- 1 electronic document : digital, PDF file
- Subjects (MeSH)
- Home Infusion Therapy
- Immunoglobulins, Intravenous
- Infusions, intravenous
- Subjects (LCSH)
- Home drug infusion therapy
- Immunoglobulins
- Intravenous therapy
- Abstract
- Part 1 outlines the program and criteria to which patients/families must adhere; Part 2 outlines troubleshooting ideas for: leaking at catheter site; local irritation (i.e. redness, swelling, itching; extreme discomfort with needle; blood return observed; long infusion times; needle contaminated by touching, dropping, etc.; infusion pump stops during infusion.
- Responsibility
- IWK Infectious Disease / Immunology, Halifax, NS
- Pamphlet Number
- PL-1237
Infections in obstetrics and gynecology : textbook and atlas
https://libcat.nshealth.ca/en/permalink/provcat22816
Petersen, Eiko E.
--Stuttgart, Germany:
Thieme
, 2006.
- Call Number
- WP 140 P484i 2006
- Location
- Dickson Building
- Call Number
- WP 140 P484i 2006
- Author
- Petersen, Eiko E
- Place of Publication
- Stuttgart, Germany
- Publisher
- Thieme
- Date of Publication
- 2006
- Physical Description
- 260 p.
- ISBN
- 1588904210
- Subjects (MeSH)
- Communicable Diseases - Female
- Genital Diseases, Female
- Pregnancy Complications, Infectious
- Diagnostic Techniques, Obstetrical and Gynecological
- Contents
- Pathogens -- Defense systems -- Detection of pathogens -- Anti-infectives (antibacterials, virostatics, antimycotics, antiparasitics, antiseptics, immunoglobulins) -- Signs of Infection -- Diagnosis of infections during gynecologic examination -- Gynecologic infections -- Infections during pregnancy -- Peripartal and puerperal infections -- Inflammation of the breast -- Sexually transmitted infections -- Helmithic infections -- Infections of other body regions -- Self-induced infections -- Prevention of infections.
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
[In French] Administration d’une perfusion sous-cutanée d’immunoglobulines à votre enfant à domicile
https://libcat.nshealth.ca/en/permalink/chpams38098
IWK. Infectious Disease / Immunology.
Halifax, NS:
IWK Health Centre
, 2021.
- Pamphlet Number
- PL-1237-FR
- Available Online
- View Pamphlet
In French. Votre enfant souffre d’une déficience ou d’un dysfonctionnement important du système immunitaire et aura besoin de perfusions d’immunoglobulines pour y remédier. Le traitement standard actuel consiste en une perfusion d’immunoglobulines par voie intraveineuse (dans une veine) ou sous-cutanée (sous la peau).
- Available Online
- View Pamphlet
- Corporate Author
- IWK. Infectious Disease / Immunology
- Alternate Title
- Renseignements sur le Programme de perfusion sous-cutanée d’immunoglobulines à domicile
- Comment résoudre des problèmes de perfusion à domicile
- Information about the Home Subcutaneous Immunoglobulin (SCIg) Infusion Program
- How to Troubleshoot Infusion Problems at Home
- Place of Publication
- Halifax, NS
- Publisher
- IWK Health Centre
- Date of Publication
- 2021
- Format
- Pamphlet
- Language
- French
- Physical Description
- 1 electronic document : digital, PDF file
- Subjects (MeSH)
- Home Infusion Therapy
- Immunoglobulins, Intravenous
- Infusions, intravenous
- Subjects (LCSH)
- Home drug infusion therapy
- Immunoglobulins
- Intravenous therapy
- Abstract
- In French. Votre enfant souffre d’une déficience ou d’un dysfonctionnement important du système immunitaire et aura besoin de perfusions d’immunoglobulines pour y remédier. Le traitement standard actuel consiste en une perfusion d’immunoglobulines par voie intraveineuse (dans une veine) ou sous-cutanée (sous la peau).
- Responsibility
- IWK Infectious Disease / Immunology, Halifax, NS
- Pamphlet Number
- PL-1237-FR
Intravenous Immunoglobulin (IVIG)
https://libcat.nshealth.ca/en/permalink/chpams36584
Nova Scotia Health Authority. QEII. Perioperative Blood Management Service.
Halifax, NS:
Nova Scotia Health Authority
, 2023.
- Pamphlet Number
- 1247
- Available Online
- View Pamphlet
IVIG is a collection of antibodies. Antibodies help your body fight infection. IVIG comes from the plasma (part of the blood) of thousands of different donors. IVIG is available under many brand names (like Gamunex®, IGIVnex®, Gammagard Liquid®, and others). This pamphlet explains how IVIG is given, benefits, and possible side effects.
- Available Online
- View Pamphlet
- Place of Publication
- Halifax, NS
- Publisher
- Nova Scotia Health Authority
- Date of Publication
- 2023
- Format
- Pamphlet
- Language
- English
- Physical Description
- 1 electronic document ([2] p.) : digital, PDF file
- Subjects (MeSH)
- Immunoglobulins, Intravenous
- Autoimmune Diseases - drug therapy
- Subjects (LCSH)
- Immunoglobulins
- Autoimmune diseases
- Specialty
- Hematology
- Abstract
- IVIG is a collection of antibodies. Antibodies help your body fight infection. IVIG comes from the plasma (part of the blood) of thousands of different donors. IVIG is available under many brand names (like Gamunex®, IGIVnex®, Gammagard Liquid®, and others). This pamphlet explains how IVIG is given, benefits, and possible side effects.
- Responsibility
- Prepared by: Perioperative Blood Management Service
- Pamphlet Number
- 1247
In Vivo Cryotechnique in Biomedical Research and Application for Bioimaging of Living Animal Organs
https://libcat.nshealth.ca/en/permalink/provcat40408
Shinichi Ohno, Nobuhiko Ohno, Nobuo Terada, editors.
(1st ed.)
--Tokyo:
Springer Japan
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book focuses on actual morphofunctional findings of cells and tissues in living animal organs. Medical and biological scientists need to know the real in vivo morphology and immunolocalization of the molecular components in living animal organs. Recently, the live imaging of cells and tissues of animals with fluorescence-labeled proteins by gene manipulation has become more and more popular in biological fields. Current research, meanwhile, has revealed that immunohistochemical or morpholo…
- Available Online
- View e-Book
- Other Authors
- Ohno, Shinichi
- Ohno, Nobuhiko
- Terada, Nobuo
- Responsibility
- Shinichi Ohno, Nobuhiko Ohno, Nobuo Terada, editors
- Edition
- 1st ed.
- Place of Publication
- Tokyo
- Publisher
- Springer Japan
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xi, 300 p. : 114 illus., 99 illus. in color)
- ISBN
- 9784431557234
- 9784431557227 (print ed.)
- Subjects (MeSH)
- Animal Structures - anatomy & histology
- Biopsy - methods
- Cryoelectron Microscopy - methods
- Freeze Substitution - methods
- Intravital Microscopy - methods
- Mice - anatomy & histology
- Abstract
- This book focuses on actual morphofunctional findings of cells and tissues in living animal organs. Medical and biological scientists need to know the real in vivo morphology and immunolocalization of the molecular components in living animal organs. Recently, the live imaging of cells and tissues of animals with fluorescence-labeled proteins by gene manipulation has become more and more popular in biological fields. Current research, meanwhile, has revealed that immunohistochemical or morphological studies exclusively depend on living animal organs. The cryotechnique is one of the most useful tools for immunohistochemistry and bioimaging of animal organs. This book describes the epoch-making cryotechnique originally developed by the editors. The book also makes the management of living animal morphology more accessible not only for biomedical researchers but also for clinical doctors, providing a valuable resource work on the current perspectives of in vivo morphology.
- Contents
- Part I. Overview -- 1. Introduction -- 2. Biomedical significance and development of "IVCT" -- 3. How to perform "IVCT" -- 4. Technical merits with "IVCT" -- Part II. Application of "IVCT" to various mouse organs -- 5. Histochemical Analyses of Living Mouse Liver under Different Hemodynamic Conditions -- 6. Three-dimensional reconstruction of liver tissues with confocal laser scanning microscopy -- 7. Application of "in vivo cryotechnique" to immunohistochemical detection of hypoxia in mouse liver tissues treated with pimonidazole -- 8. Immunohistochemical detection of soluble immunoglobulins in small intestines -- 9. Detection of MAPK signal transduction proteins in an ischemia/reperfusion model of small intestines -- 10. Histological Study and LYVE-1 Immunolocalization of Mesenteric Lymph Nodes -- 11. Distribution of immunoglobulin-producing cells in immunized mouse spleens -- Chapter12. Alteration of erythrocyte shapes in various organs of living mice or under blood flow conditions -- 13. Dynamic ultrastructure of smooth muscle cells in dystrophin-deficient mdx or normal scn mice -- 14. Dynamic Bioimaging of Serum Proteins in Beating Mouse Hearts -- 15. Histochemical analyses and quantum dot imaging of microvascular blood flow with pulmonary edema -- 16. Dynamic ultrastructure of pulmonary alveoli of living mice under respiratory conditions -- 17. Immunohistochemical analysis of various serum proteins in living mouse thymus -- 18. Immuno- and enzyme-histochemistry of HRP for demonstration of blood vessel permeability in mouse thymic tissues -- 19. Immunolocalization of serum proteins in living mouse glomeruli under various hemodynamic conditions -- 20. Immunohistochemical Analyses on Albumin and IgG in Acute Hypertensive Mouse Kidneys -- 21. Application of novel "in vivo cryotechnique" in living animal kidneys -- 22. Application of periodic acid-Schiff fluorescence emission for imunohistochemistry of living mouse renal glomeruli -- 23. Immunohistochemical analyses on serum proteins in nephrons of protein-overload mice -- 24. Immunohistochemical analyses of serum proteins in puromycin aminonucleoside nephropathy of living rat kidneys -- 25. Immunolocalization of phospho-Arg-directed protein kinase-substrate in hypoxic kidneys -- 26. Dynamic ultrastructures of renal glomeruli in living mice under various hemodynamic conditions -- 27. Function of dynamin-2 in formation of discoid vesicles in urinary bladder umbrella cells -- 28. Involvement of follicular basement membrane and vascular endothelium in blood-follicle barrier formation of mice -- 29. Permselectivity of blood-follicle barriers in mouse polycystic ovary model -- 30. Application of "in vivo cryotechnique" to immunohistochemical study of serum albumin in normal and cadmium-treated mouse testis organs -- 31. Immunohistochemical detection of angiotensin II receptors in mouse cerebellum -- 32. Application of "in vivo cryotechnique" to immunohistochemical analyses for effects of anoxia on serum immunoglobulin and albumin leakage through blood-brain barrier in mouse cerebellum -- 33. Extracellular Space in Central Nervous System -- 34. Overview on recent applications of in vivo cryotechnique in neurosciences -- 35. Application of "in vivo cryotechnique" to immunohistochemical detection of phosphorylated rhodopsin in light-exposed retina of living mouse -- 36. Application of "in vivo cryotechnique" to immunohistochemical detection of glutamate in mouse retina inner segment of photoreceptors -- 37. Application of ǣin vivo cryotechniqueǥ to immunohistochemical study of mouse sciatic nerves under various stretching conditions -- Part III. Further preparation after "IVCT" -- 38. Freeze-substitution (FS) fixation method -- Part IV. Comments on advantages of "IVCT" -- 39. Cryotechniques and freeze-substitution for immunostaining of intranuclear antigens and fluorescence in situ hybridization -- 40. Replica immunoelectron microscopy for caveolin in living smooth muscle cells -- 41. Application of "in vivo cryotechnique" to detection of injected fluorescence-conjugated IgG in living mouse organs -- 42. Application of "in vivo cryotechnique" to visualization of microvascular blood flow in mouse kidney by quantum dot injection -- Part V. Direct detection of molecules by Raman microscopy -- 43. Application of "in vivo cryotechnique" to Raman microscopy of freeze-dried mouse eyeball-slice -- 44. Application of "in vivo cryotechnique" to detection of erythrocyte oxygen saturation in mouse blood vessels with confocal Raman cryomicroscopy -- Part VI. Future development for human pathology -- 45. Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis -- 46. Differential distribution of blood-derived proteins in xenografted human adenocarcinoma tissues -- Part VII. New cryobiopsy invention -- 47. Morphological and Histochemical Analysis of Living Mouse Livers by New "Cryobiopsy" Technique -- 48. Recent Development of In Vivo Cryotechnique to Cryobiopsy for Living Animals -- Part VIII. Application of cryobiopsy for living animal tissues -- 49. Significance of cryobiopsy for morphological and immunohistochemical analyses of xenografted human lung cancer tissues and functional blood vessels -- 50. Immunolocalization of serum proteins in xenografted mouse model of human tumor cells -- 51. Histochemical approach of cryobiopsy for glycogen distribution in living mouse livers under fasting and local circulation loss conditions -- Part IX. New bioimaging of living animal tissues -- 52. Bioimaging of fluorescence-labeled mitochondria in subcutaneously grafted murine melanoma cells by the 'in vivo cryotechnique" -- 53. Application of "in vivo cryotechnique" to visualization of ATP with luciferin-luciferase reaction in mouse skeletal muscles -- 54. Concluding remarks.
- Format
- e-Book
- Location
- Online
Maternal Drug Use and Infant Congenital Malformations
https://libcat.nshealth.ca/en/permalink/provcat44476
Bengt Källén.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book is the combination of the literature on maternal drug use and birth defects with a set of new data on most types of drugs. In this book, for each group of drugs the relevant scientific literature on drug teratogenicity is presented, with consideration of possible sources of error and also what the findings may mean from a practical point of view. The book also adds data from the Swedish health registers for 1996-2013 based on more than 1.7 million early-pregnancy midwife interviews. M…
- Available Online
- View e-Book
- Author
- Källén, Bengt
- Responsibility
- Bengt Källén
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xviii, 425 p.) : 16 illus. in color
- ISBN
- 9783030178987
- 9783030178970 (Print ed.)
- 9783030178994 (Print ed.)
- 9783030179007 (Print ed.)
- Subjects (MeSH)
- Abnormalities, Drug-Induced
- Fetus - drug effects
- Maternal-Fetal Exchange
- Pharmaceutical Preparations - adverse effects
- Specialty
- Embryology
- Toxicology
- Abstract
- This book is the combination of the literature on maternal drug use and birth defects with a set of new data on most types of drugs. In this book, for each group of drugs the relevant scientific literature on drug teratogenicity is presented, with consideration of possible sources of error and also what the findings may mean from a practical point of view. The book also adds data from the Swedish health registers for 1996-2013 based on more than 1.7 million early-pregnancy midwife interviews. Maternal Drug Use and Infant Congenital Malformations will find an engaged audience among people working within the field, and will be of interest to healthcare providers, especially obstetricians and other clinicians who treat women of childbearing age.
- Contents
- Background -- Maternal use of antacids or drugs for GERD and infant congenital malformations -- Maternal use of drugs for intestinal problems, except intestinal inflammations, and infant congenital malformations -- Maternal use of drugs for inflammatory intestinal disease and infant congenital malformations -- Maternal use of anti-obesity drugs and infant congenital malformations -- Maternal use of insulin or oral hypoglycemic drugs and infant congenital malformations -- Maternal use of vitamins and infant congenital malformations -- Maternal use of anticoagulants and hemostatic drugs and infant congenital malformations -- Maternal use of drugs for cardiovascular diseases and infant congenital malformations -- Maternal use of dermatological drugs and infant congenital malformations -- Maternal use of prolactin inhibitors or sex hormones and infant congenital malformations -- Maternal use of drugs for thyroid disease and infant congenital malformations -- Maternal systemic use of corticosteroids and infant congenital malformations -- Maternal use of hypophyseal or hypothalamic hormones and infant congenital malformations -- Maternal use of antibacterial or antifungal drugs and infant congenital malformations -- Maternal use of antiviral drugs, immunoglobulins, or vaccines and infant congenital malformations -- Maternal use of cytostatic/cytotoxic drugs or endocrine drugs used for malignancy and infant congenital malformations -- Maternal use of immunostimulating or immunosuppressive drugs and infant congenital malformations -- Maternal use of NSAID drugs and infant congenital malformations -- Maternal use of drugs other than NSAIDs for musculoskeletal diseases and infant congenital malformations -- Maternal use of opiates or opioid analgesics and infant congenital malformations -- Maternal use of mild analgesics and infant congenital malformations -- Maternal use of drugs for migraine and infant congenital malformations -- Maternal use of anticonvulsants and infant congenital malformations -- Maternal use of antipsychotics and infant congenital malformations -- Maternal use of sedatives or hypnotics and infant congenital malformations -- Maternal use of antidepressants and infant congenital malformations -- Maternal use of other psychoactive drugs and infant congenital malformations -- Maternal use of antiprotozoans, antihelminthics or insecticides and infant congenital malformations -- Maternal use of nasal decongestants, other nasal preparations, or throat preparations and infant congenital malformations -- Maternal use of anti-asthmatics and infant congenital malformations -- Maternal use of cough and common cold medicines and infant congenital malformations -- Maternal use of drugs for nausea and vomiting in pregnancy and infant congenital malformations -- Maternal use of antihistamine drugs for allergy and infant congenital malformations -- Maternal use of local eye and ear drug therapy and infant congenital malformations -- Maternal use of some groups of drugs with common side effects and infant congenital malformations -- The practical consequences of observed associations between the use of drug and infant congenital malformation.
- Format
- e-Book
- Location
- Online
Neoplastic diseases of the blood
https://libcat.nshealth.ca/en/permalink/provcat32370
Peter H. Wiernik, John M. Goldman, Janice P. Dutcher ... [et al.], editors.
(5th ed.)
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia' Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text b…
- Available Online
- View e-Book
- Other Authors
- Wiernik, Peter H
- Responsibility
- Peter H. Wiernik, John M. Goldman, Janice P. Dutcher ... [et al.], editors
- Edition
- 5th ed.
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xix, 1431 p. : 224 ill., 143 ill. in color)
- ISBN
- 9781461437642
- Subjects (MeSH)
- Hematologic Neoplasms
- Leukemia
- Lymphoma
- Multiple Myeloma
- Subjects (LCSH)
- Internal medicine
- Hematology
- Oncology
- Abstract
- Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia' Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.
- Contents
- A History of the Chronic Leukemias -- Etiology and Epidemiology of Chronic Myeloid Leukemia -- Pathology of the Chronic Myeloid Leukemias -- Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia -- Diagnosis and Treatment of Chronic Myeloid Leukemia -- Etiology and Epidemiology of CLL -- Histopathology, Morphology, and Immunophenotyping of CLL -- Molecular Biology and Cytogenetics of Chronic Lymphocytic Leukemia -- Treatment of Chronic Lymphocytic Leukemia and Related Disorders -- Hairy Cell Leukemia -- The Pathogenesis, Diagnosis, and Treatment of Polycythemia Vera -- Diagnosis and Treatment of Essential Thrombocythemia and Primary Myelofibrosis -- History of Acute Leukemia -- The Etiology of Acute Leukemia -- Epidemiology and Hereditary Aspects of Acute Leukemia -- Classification of the Acute Leukemias: Cytochemical and Morphologic Considerations -- Immunobiology of Acute Leukemia -- Cytogenetics of Acute Leukemia -- Diagnosis and Treatment of Childhood Acute Lymphoblastic Leukemia -- Diagnosis and Treatment of Adult Acute Lymphoblastic Leukemia -- Diagnosis and Treatment of Childhood Acute Myeloid Leukemia -- Diagnosis and Treatment of Adult Acute Myeloid Leukemia Other Than Acute Promyelocytic Leukemia -- Acute Promyelocytic Leukemia -- Therapy-Related Acute Myelogenous Leukemia -- The Myelodysplastic Syndromes -- History of Multiple Myeloma -- Cytokines and Signal Transduction in Multiple Myeloma -- Epidemiology of Multiple Myeloma -- Immunoglobulins and Laboratory Recognition of Monoclonal Proteins -- Cytogenetic Abnormalities in MGUS and Myeloma -- Molecular Genetics of Myeloma -- Prognosis and Staging of Multiple Myeloma -- Diagnosis and Treatment of Multiple Myeloma -- Complications and Special Presentations of Plasma Cell Myeloma -- Waldenstrœm's Macroglobulinemia -- Heavy-Chain Disease -- Diagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis) -- Monoclonal Gammopathy of Undetermined Significance -- Historical Landmarks in the Understanding of the Lymphomas -- Genetics in Lymphomagenesis -- Epidemiology and Hereditary Aspects of Hodgkin and Non-Hodgkin Lymphomas -- Pathology of Non-Hodgkin and Hodgkin Lymphomas -- Immunology of the Lymphomas -- Cytogenetics of Lymphomas -- Diagnosis and Treatment of Hodgkin's Lymphoma -- Radiotherapeutic Management of Lymphomas -- Diagnosis and Treatment of Non-Hodgkin's Lymphoma of Adults -- Non-Hodgkin Lymphoma of Childhood -- Lymphoma in Other Diseases -- Supportive Care for Patients with Leukemia: A Historical Perspective -- Prevention of Infections in Patients with Hematological Malignancies -- Evaluation and Management of Bacterial and Fungal Infections Occurring in Patients with a Hematological Malignancy: A 2011 Update -- Viral Infections in Patients with Hematological Malignancies -- Therapeutic Cytapheresis, Plasmapheresis, and Plasma Exchange in Neoplastic Diseases of the Blood -- Red Cell Transfusions in Patients with Hematologic Malignancies -- Platelet and Granulocyte Transfusion -- Alternative Sources of Hematopoietic Stem Cells and Their Clinical Applications -- HLA Typing in Support of Hematopoietic Cell Transplantation from Unrelated Donors -- Special Care of Blood and Marrow Stem Transplant Patients -- Hematopoietic Growth Factors in the Supportive Care and Treatment of Patients with Hematologic Neoplasms -- Bleeding and Thrombosis in Hematologic Neoplasia -- Psychological Aspects of Hematological Neoplasms -- Index.
- Format
- e-Book
- Location
- Online
Ovarian hyperstimulation syndrome : epidemiology, pathophysiology, prevention and management
https://libcat.nshealth.ca/en/permalink/provcat27259
Botros R. M. B. Rizk.
--Cambridge, UK:
Cambridge University Press
, 2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Rizk, Botros
- Responsibility
- Botros R. M. B. Rizk
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- 2006
- Physical Description
- xiv, 233 p., [4] p. of plates
- ISBN
- 6610480001 (electronic bk.)
- Subjects (MeSH)
- Ovarian Hyperstimulation Syndrome
- Contents
- Cover -- Half-title -- Title -- Copyright -- Dedication -- Contents -- Foreword -- A complicated complication -- Preface -- I Classification of ovarian hyperstimulation syndrome -- The purpose of ovarian hyperstimulation syndrome classifications -- Overview of OHSS classifications -- The first classification of OHSS -- Reorganization of OHSS classification -- Modernization of the OHSS classification -- Designation of critical OHSS as a special entity -- Clinical classification of OHSS -- Early and late OHSS -- Spontaneous and iatrogenic OHSS -- REFERENCES -- II Epidemiology of ovarian hyperstimulation syndrome: iatrogenic and spontaneous -- The impact of in vitro fertilization on the development of OHSS -- Characterization of patients at risk of severe OHSS -- Factors that influence the incidence of OHSS -- Selection of Patients -- Polycystic ovarian syndrome -- Hyperinsulinism and OHSS -- Allergy -- Ovarian stimulation protocol -- Gonadotrophins -- Pregnant Mare Serum Gonadotrophins -- Human Pituitary Gonadotrophins -- Human Menopausal Gonadotrophin -- Purified Urinary Follicle Stimulating Hormone -- Recombinant Follicle Stimulating Hormone -- Long-acting Recombinant Follicle Stimulating Hormone -- Fixed-dose Gonadotrophins -- Clomiphene citrate -- Gonadotrophin-releasing hormone agonist -- Gonadotrophin-releasing Hormone Agonist without Gonadotrophins -- Gonadotrophin-releasing Hormone Agonist Long Protocol -- OHSS in GnRH antagonist protocols -- Luteal phase support and the role of luteal hCG in the genesis of OHSS -- OHSS and conception cycles -- Frequency of OHSS and Conception Cycles -- Duration of OHSS and Conception Cycles -- Spontaneous OHSS -- Time course development of spontaneous OHSS -- Spontaneous OHSS and hCG levels -- Recurrent OHSS -- Familial OHSS -- Hypothyroidism and OHSS -- Spontaneous OHSS and DVT -- The role of an OHSS registry -- REFERENCES -- III Pathophysiology of ovarian hyperstimulation syndrome -- Role of peripheral arteriolar dilatation -- Osmoregulation in patients with OHSS -- Increased erythrocyte aggregation in OHSS -- Immunoglobulins in OHSS -- Source of the peritoneal fluid -- Mediators of increased capillary permeability -- Estrogens -- Progesterone -- The Ovarian Renin-Angiotensin System -- Studies of Angiotensin-converting Enzyme Inhibitors and Angiotensin Receptor Blockers -- Prostaglandins -- von Willebrand Factor -- Endothelin-1 -- Vascular endothelial growth factor -- Discovery and Cloning -- VEGF receptors -- Tyrosine Kinase Receptors -- VEGF165 Specific Receptor Neuropilin-1 -- VEGF gene expression -- Regulation of VEGF production -- VEGF Isoforms -- Role of VEGF in Physiological and Pathological States -- What is the link between VEGF and OHSS? -- VEGF as a capillary permeability agent in OHSS -- VEGF mRNA expression in the rat and primate ovary -- VEGF m-RNA Expression in Human Luteinized Granulosa Cells -- VEGF Dynamic Studies and OHSS -- VEGF in Follicular Fluid and GnRH Antagonist -- VEGF Soluble Receptor -- Free VEGF or Total VEGF
- Format
- e-Book
- Location
- Online
Practical Issues Updates in Anesthesia and Intensive Care
https://libcat.nshealth.ca/en/permalink/provcat39309
Davide Chiumello, editor.
--Cham:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book describes the state of the art concerning some of the most hotly debated topics in anesthesia and intensive care and is at the same time intended to serve as a useful practical guide that will assist in improving outcomes. The topics covered are wide ranging and include, for example, use of the prone position in ARDS, the role of therapeutic hypothermia in the critically ill, the value of immunoglobulins in the treatment of severe sepsis, drug management of septic shock, new strategie…
- Available Online
- View e-Book
- Other Authors
- Chiumello, Davide
- Responsibility
- Davide Chiumello, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (viii, 199 p. : 20 illus., 12 illus. in color)
- ISBN
- 9783319180663
- 9783319180656 (print ed.)
- Subjects (MeSH)
- Anesthesia - methods
- Anesthesiology - methods
- Critical Care - methods
- Abstract
- This book describes the state of the art concerning some of the most hotly debated topics in anesthesia and intensive care and is at the same time intended to serve as a useful practical guide that will assist in improving outcomes. The topics covered are wide ranging and include, for example, use of the prone position in ARDS, the role of therapeutic hypothermia in the critically ill, the value of immunoglobulins in the treatment of severe sepsis, drug management of septic shock, new strategies for prevention of ventilator-associated pneumonia, non-invasive ventilation outside of the ICU, management of postoperative bleeding, and prognostic factors in cardiac arrest. Written by recognized experts in the field, the book will offer a comprehensive and easy to understand update for specialists and students of anesthesia and intensive care.
- Contents
- 1. The Prone Position in the Treatment of Patients with ARDS: Problems and Real Utility -- 2. Therapeutic Hypothermia in the Intensive Care Unit -- 3. Which Among Septic Patients Are the Best Candidate for Immunoglobulins? -- 4. The Role of Noradrenaline, Vasopressin, and Terlipressin in Septic Shock -- 5. The Most Recent Strategies for VAP (Ventilator-Associated Pneumonia) Prevention -- 6. Hemodynamic Optimization in the Perioperative Period: General Guidelines and a Comparison of Personalized Strategies -- 7. Management Strategies in the Postoperative Course, with Particular Attention to Pain Treatment: Revision of the Most Recent Knowledge -- 8. Optimum Management of Perioperative Coagulation in Patients with Spontaneous Intracranial Haemorrhage -- 9. Postpartum Haemorrhage (PPH): Diagnosis, Prevention and Treatment -- 10. Noninvasive Ventilation Outside the Critical Care Unit -- 11. Interventional Cardiology: The Role of the Anesthesiologist -- 12. All You Need to Know About the Meaning of Plasmatic Lactate Level -- 13. Clinical Use of Indocyanine Green (ICG) Kinetics in Liver Anaesthesia and ICU.
- Format
- e-Book
- Location
- Online
Radiopharmaceutical Chemistry
https://libcat.nshealth.ca/en/permalink/provcat44334
Jason S. Lewis, Albert D. Windhorst, Brian M. Zeglis, editors.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical …
- Available Online
- View e-Book
- Other Authors
- Lewis, Jason S.
- Windhorst, Albert D.
- Zeglis, Brian M.
- Responsibility
- Jason S. Lewis, Albert D. Windhorst, Brian M. Zeglis, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xviii, 651 p.) : 530 illus., 318 illus. in color
- ISBN
- 9783319989471
- 9783319989464 (Print ed.)
- 9783319989488 (Print ed.)
- Subjects (MeSH)
- Nuclear Pharmacy
- Radiochemistry
- Radiopharmaceuticals - chemistry
- Specialty
- Pharmacy
- Radiotherapy
- Abstract
- This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.
- Contents
- Part I. First Principles -- Why Nuclear Imaging and Radiotherapy? -- A Short History of Nuclear Medicine -- The Basics of Nuclear Chemistry and Radiochemistry: An Introduction to Nuclear Transformations and Radioactive Emissions -- Methods for the Production of Radionuclides for Medicine -- An Overview of Targeted Radiotherapy -- An Overview of Nuclear Imaging -- Small Molecules as Radiopharmaceutical Vectors -- Peptides as Radiopharmaceutical Vectors -- Immunoglobulins as Radiopharmaceutical Vectors -- Nanoparticles as Radiopharmaceutical Vectors -- Part II. Radiochemistry -- The Radiopharmaceutical Chemistry of Carbon-11: Basic Principles -- The Radiopharmaceutical Chemistry of Carbon-11: Tracers and Applications -- The Radiopharmaceutical Chemistry of Nitrogen-13 and Oxygen-15 -- The Radiopharmaceutical Chemistry of the Radionuclides of Gallium and Indium -- The Radiopharmaceutical Chemistry of Fluorine-18: Nucleophilic Fluorinations -- The Radiopharmaceutical Chemistry of Fluorine-18: Electrophilic Fluorinations -- The Radiopharmaceutical Chemistry of Fluorine-18: Next-Generation Fluorinations -- The Radiopharmaceutical Chemistry of Technetium-99m -- The Radiopharmaceutical Chemistry of the Radioisotopes of Copper -- The Radiopharmaceutical Chemistry of the Radioisotopes of Lutetium and Yttrium -- The Radiopharmaceutical Chemistry of Zirconium-89 -- The Radiopharmaceutical Chemistry of the Radioisotopes of Iodine -- The Radiopharmaceutical Chemistry of Alpha-Emitting Radionuclides -- The Radiopharmaceutical Chemistry of Seldom-Used Radionuclides in Nuclear Medicine -- Part III. Special Topics -- Bioconjugation Methods for Radiopharmaceutical Chemistry -- Click Chemistry in Radiopharmaceutical Chemistry -- Equipment and Instrumentation for Radiopharmaceutical Chemistry -- Kinetic Modeling of Radiotracers -- An Introduction to Radiation Protection -- An Introduction to Biostatistics -- Choosing a Target for Nuclear Imaging or Targeted Radiotherapy -- Target Identification, Lead Discovery, and Optimization -- Preclinical Experimentation in Oncology -- Preclinical Experimentation in Neurology -- The Clinical Translation Process in Europe -- The Clinical Translation Process in the United States -- Setting Up a Successful Radiopharmaceutical Production Facility.
- Format
- e-Book
- Location
- Online
Reducing Mortality in Acute Kidney Injury
https://libcat.nshealth.ca/en/permalink/provcat40246
Giovanni Landoni, Antonio Pisano, Alberto Zangrillo, Rinaldo Bellomo, editors.
--Cham:
Springer
, c2016.
- Available Online
- View e-Book
- Location
- Online
This book describes the techniques, strategies, and drugs that have been demonstrated by at least one paper published in a peer-reviewed journal to significantly influence survival in patients with or at risk for acute kidney injury. Each chapter focuses on a specific intervention. The scope is accordingly wide, with coverage of topics as diverse as the type, timing, and dose of renal replacement therapy (RRT), anticoagulation and specific indications for RRT, perioperative hemodynamic optimiza…
- Available Online
- View e-Book
- Other Authors
- Landoni, Giovanni
- Pisano, Antonio
- Zangrillo, Alberto
- Bellomo, Rinaldo
- Responsibility
- Giovanni Landoni, Antonio Pisano, Alberto Zangrillo, Rinaldo Bellomo, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2016
- Physical Description
- 1 online resource (ix, 203 p. : 10 illus., 9 illus. in color)
- ISBN
- 9783319334295
- 9783319334271 (print ed.)
- Abstract
- This book describes the techniques, strategies, and drugs that have been demonstrated by at least one paper published in a peer-reviewed journal to significantly influence survival in patients with or at risk for acute kidney injury. Each chapter focuses on a specific intervention. The scope is accordingly wide, with coverage of topics as diverse as the type, timing, and dose of renal replacement therapy (RRT), anticoagulation and specific indications for RRT, perioperative hemodynamic optimization, fluid balance, diuretics, colloids, fenoldopam, terlipressin, N-acetylcysteine, and vasopressin. A variety of settings are considered, including critically ill patients, cardiac surgery, and hepatic and hematologic disorders. The topic selection was made using a democracy-based approach in which hundreds of specialists from dozens of countries expressed, via the web, whether they agreed with these topics and whether they used the techniques in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. The book will be of interest for a wide variety of specialists, including intensivists, nephrologists, emergency doctors, and anesthesiologists.
- Contents
- Part I. Introduction -- Acute kidney injury: the plague of the new millennium -- Acute kidney injury: definitions, incidence, diagnosis, and outcome -- Reducing mortality in acute kidney injury: the democracy-based approach to consensus -- Part II. Interventions that may reduce mortality -- Continuous renal replacement therapy vs. intermittent hemodialysis: impact on clinical outcomes -- May an "early" renal replacement therapy improve survival? -- Increased intensity of renal replacement therapy to reduce mortality in patients with acute kidney injury -- Citrate anticoagulation to reduce mortality in patients needing continuous renal replacement therapy -- Peri-angiography hemofiltration to reduce mortality -- Continuous venovenous hemofiltration to reduce mortality in severely burned patients -- Perioperative hemodynamic optimization to reduce acute kidney injury and mortality in surgical patients -- Furosemide by continuous infusion to reduce mortality in patients with acute kidney injury -- N-acetylcysteine to reduce mortality in cardiac surgery -- Fenoldopam and acute kidney injury. Is it time to turn the page? -- Vasopressin to reduce mortality in patients with septic shock and acute kidney injury -- Terlipressin reduces mortality in hepatorenal syndrome -- Albumin to reduce mortality in cirrhotic patients with acute kidney injury -- Extracorporeal removal of serum free light chains in patients with multiple-myeloma associated acute kidney injury -- Can intravenous human immunoglobulins reduce mortality in patients with (septic) acute kidney injury? -- Part III. Interventions that may increase mortality -- Fluid overload may increase mortality in patients with acute kidney injury -- Hydroxyethyl starch, acute kidney injury, and mortality -- Loop diuretics and mortality in patients with acute kidney injury -- Part IV. Update -- Reducing mortality in patients with acute kidney injury: a systematic update.
- Format
- e-Book
- Location
- Online
