60 years of survival outcomes at the University of Texas MD Anderson Cancer Center
https://libcat.nshealth.ca/en/permalink/provcat32423
M. Alma Rodriguez, Ronald S. Walters, Thomas W. Burke, editors.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
This unique book provides a retrospective analysis of the changes in survival outcomes at The University of Texas M.D. Anderson Cancer Center over the past six decades. Since opening its doors in 1944, M.D. Anderson has kept a continuous, uninterrupted data repository of the treatment and outcomes of each of its patients. It is this visionary database from the Center's tumor registry which makes this groundbreaking book possible. Tracking results across time, the book shows radical shifts in ou…
- Available Online
- View e-Book
- Other Authors
- Rodriguez, M. Alma
- Walters, Ronald S
- Burke, Thomas W
- Responsibility
- M. Alma Rodriguez, Ronald S. Walters, Thomas W. Burke, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xiii, 346 p. : 124 ill. in color)
- ISBN
- 9781461451976
- Subjects (MeSH)
- Academies and Institutes - history
- History, 20th century
- History, 21st century
- Neoplasms - epidemiology
- Neoplasms - therapy
- Registries
- Survival Analysis
- Texas - epidemiology
- Treatment Outcome
- Subjects (LCSH)
- Oncology
- Epidemiology
- Abstract
- This unique book provides a retrospective analysis of the changes in survival outcomes at The University of Texas M.D. Anderson Cancer Center over the past six decades. Since opening its doors in 1944, M.D. Anderson has kept a continuous, uninterrupted data repository of the treatment and outcomes of each of its patients. It is this visionary database from the Center's tumor registry which makes this groundbreaking book possible. Tracking results across time, the book shows radical shifts in outcomes trends, where great progress has been made, and where there is still a long way to go, and offers a snapshot of the parallel history of developments in care. Such data is crucial to informing how patients are counseled, how treatment decisions are determined, and how prognoses are made. 60 Years of Survival Outcomes at The University of Texas M.D. Anderson Cancer Center is the only book to concurrently present longitudinal data on survival outcomes across the spectrum of rare and common cancers. Each chapter deals with a specific disease site, discussing current management approaches and presenting key data replete with illustrative charts, graphs, and tables. With the resources available only to the practitioners at this inimitable institution, this book heralds a cornerstone moment in the study of survival outcomes and the depth of our knowledge of cancer care.
- Contents
- Ch. 1:Introduction -- Ch. 2:History of MD Anderson's Tumor Registry -- Ch. 3:Statistical Methods -- Ch. 4:Breast Cancer -- Ch. 5:Prostate Cancer -- Ch. 6:Non-Small Cell Lung Cancer -- Ch. 7:Small Cell Lung Cancer -- Ch. 8:Colon Cancer -- Ch. 9:Ovarian Cancer -- Ch. 10:Cervical Cancer -- Ch. 11:Endometrial Cancer -- Ch. 12:Pancreatic Cancer (Exocrine) -- Ch. 13:Kidney Cancer -- Ch. 14:Bladder Cancer -- Ch. 15:Cutaneous Melanoma -- Ch. 16:Liver Cancer -- Ch. 17:Esophageal Cancer -- Ch. 18:Gastric Cancer -- Ch. 19:Acute Myeloid Leukemia -- Ch. 20:Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma -- Ch. 21:Hodgkin Lymphoma -- Ch. 22:Non-Hodgkin Indolent B-Cell Lymphoma -- Ch. 23:Non-Hodgkin Aggressive B-Cell Lymphoma -- Ch. 24:Multiple Myeloma -- Ch. 25:Head and Neck Cancer -- Ch. 26:Thyroid Cancer -- Ch. 27:Soft Tissue Sarcomas -- Ch. 28:Sarcomas of Bone -- Index.
- Format
- e-Book
- Location
- Online
An introduction to emergency exercise design and evaluation
https://libcat.nshealth.ca/en/permalink/provcat30688
McCreight, Robert.
--Rockville, MD:
Government Institutes
, 2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- McCreight, Robert
- Alternate Title
- Introduction to emergency exercise design and evaluation
- Place of Publication
- Rockville, MD
- Publisher
- Government Institutes
- Date of Publication
- 2011
- Physical Description
- 176 p.
- ISBN
- 9781605907604
- Subjects (MeSH)
- Disaster Planning
- Emergencies
- Subjects (LCSH)
- Emergency management--Study and teaching
- Format
- e-Book
- Location
- Online
Cancer Immunology : Bench to Bedside Immunotherapy of Cancers
https://libcat.nshealth.ca/en/permalink/provcat39431
Nima Rezaei, editor.
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the…
- Available Online
- View e-Book
- Other Authors
- Rezaei, Nima
- Responsibility
- Nima Rezaei, editor
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (l, 485 p. : 45 illus., 38 illus. in color)
- ISBN
- 9783662449462
- 9783662449455 (print ed.)
- Subjects (MeSH)
- Immunotherapy - methods
- Neoplasms - therapy
- Abstract
- This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.
- Contents
- Frontiers in Cancer Immunotherapy -- Novel Strategy of Cancer Immunotherapy: Spiraling Up -- Novel Prognostic Biomarkers for Personalized Cancer Treatments -- Tumor Antigen and Epitope Identification for Pre-Clinical and Clinical Evaluation -- Strategies to Target Tumor Immunesuppression -- Immune Modulation of Drugs in Prevention and Treatment of Cancers -- Overcoming Immune Tolerance With Immune Checkpoint Blockade -- Gene therapy and Virus-Based Cancer Vaccines -- Cancer Stem Cells: Biology and Potential therapeutic Applications -- Hematopoietic Stem Cell Transplantation and Lymphodepletion in Treatment of Cancers -- Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers -- T Cell Immunotherapy: From Synthetic Biology to Clinical Practice -- Role of Gamma-Delta T Lymphocytes in Cancer Immunosurveillance and Immunotherapy -- Adoptive T Cell therapy: Optimizing Chemokine Receptor-Mediated Homing of T Cells in Cancer Immunotherapy -- Cellular therapy of Cancer With B Effector Cells -- Monoclonal Antibodies for Treatment of Cancers -- Pattern Recognition Receptors in Cancers and Immunotherapy by Triggering or Targeting of Toll Like Receptors Pathway -- Recent Advances in the Use of NK Cells Against Cancer -- Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials -- Tumor Associated Macrophages and iNOS in Cancer Immunotherapy -- Photodynamic therapy and Anti-Tumor Immune Response -- Polarization of Tumor Milieu: Therapeutic Implications -- Immunotherapies Targeting 5T4 Oncofoetal Glycoprotein -- Immune Monitoring During Clinical Development of Anti-CTLA-4 Antibody Therapy -- PD-1 Blockade in Cancer Therapy -- New Advances in Radioimmunotherapy for the Treatment of Cancers -- Psychoneuroendocrinoimmunotherapy of Cancers -- Ethical Considerations in Cancer Immunotherapy.
- Format
- e-Book
- Location
- Online
CIHR best practices for protecting privacy in health research : September 2005
https://libcat.nshealth.ca/en/permalink/provcat22288
Canadian Institutes of Health Research.
--Ottawa, ON:
Canadian Institutes of Health Research
, 2005.
- Call Number
- W 20.55 .H9 C212c 2005
- Location
- Dickson Building
- Call Number
- W 20.55 .H9 C212c 2005
- Corporate Author
- Canadian Institutes of Health Research
- Place of Publication
- Ottawa, ON
- Publisher
- Canadian Institutes of Health Research
- Date of Publication
- 2005
- Physical Description
- 161 p.
- ISBN
- 0662410564
- Subjects (MeSH)
- Biomedical Research - ethics
- Human Experimentation - standards
- Confidentiality - standards
- Privacy
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
Development of Antibody-Based Therapeutics : Translational Considerations & Challenges
https://libcat.nshealth.ca/en/permalink/provcat42727
Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors.
(2nd edition)
--Singapore:
Adis
, c2018.
- Available Online
- View e-Book
- Location
- Online
With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2…
- Available Online
- View e-Book
- Other Authors
- Tabrizi, Mohammad A.
- Bornstein, Gadi G.
- Klakamp, Scott L.
- Responsibility
- Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors
- Edition
- 2nd edition
- Place of Publication
- Singapore
- Publisher
- Adis
- Date of Publication
- c2018
- Physical Description
- 1 online resource (viii, 248 p.) : 106 illus., 87 illus. in color
- ISBN
- 9789811304965
- 9789811304958 (print ed.)
- 9789811304972 (print ed.)
- Subjects (MeSH)
- Antibodies, Monoclonal - pharmacology
- Antibodies, Monoclonal - therapeutic use
- Antigens - immunology
- Drug Discovery
- Translational Medical Research
- Specialty
- Pharmacology
- Regenerative Medicine
- Abstract
- With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students. Mohammad A. Tabrizi, Ph.D. is a leader in translational sciences as related to development of antibody-based therapeutics. His product development experience spans many therapeutic areas including oncology and inflammatory disease, and his technical expertise includes preclinical pharmacology and safety, preclinical and clinical pharmacokinetics, pharmacodynamics, GLP-compliant bioanalytics, and clinical pharmacology of therapeutic monoclonal antibodies. Gadi Bornstein, Ph.D. has over seventeen years of experience in Oncology R&D with an emphasis in preclinical antibody discovery and development. Dr. Bornstein currently leads and directs biologics discovery efforts at TESARO. He received his B.S. in biochemistry at the University of California, Davis and his doctoral degree in biochemistry at the University of Southern California Keck School of Medicine. Dr. Bornstein completed his postdoctoral training at Stanford University in the Division of Immunology and Rheumatology. Following his postdoctoral training, Dr. Bornstein joined Amgen Fremont, Inc. (formerly Abgenix, Inc.) as a Staff Scientist in the Preclinical Oncology department. Dr. Bornstein has held roles of increasing responsibility at AstraZeneca, Pfizer, and Novartis, where he was a project team leader, lead biologist, and key contributor to scientific strategies for multiple oncology programs. Dr. Bornstein has authored numerous research papers, reviews, as well as book chapters, and is a co-inventor on multiple patents. Scott L. Klakamp, Ph.D. is one of the leading scientists in utilizing Surface Plasmon Resonance (SPR) and KinExA’ to measure the binding kinetics and equilibrium dissociation constants of human monoclonal antibody/antigen complexes. He was the founder of SKD Consulting LLC and acted as Principal Consultant at that company during the development of this title. Prior to SKD Consulting LLC, he was the Vice President of Chemistry and Biochemistry at BiOptix Inc., a company that provided the 404pi biosensor. Dr. Klakamp has also held positions of increasing responsibility in the areas of analytical and biophysical characterization at Chiron, Amgen/Abgenix, AstraZeneca/MedImmune, and Takeda Pharmaceuticals. Dr. Klakamp has been an author on over 30 research and review papers, book chapters, and patents. He has also been an invited speaker at numerous international and national meetings. Dr. Klakamp received his B.A. in Chemistry from Houghton College and his PhD in Chemistry at the Pennsylvania State University. From 1990 to 1993, he completed a postdoctoral fellowship (funded by a National Research Service Award from the National Institutes of Health) at the California Institute of Technology in bioinorganic chemistry.
- Contents
- 1. Introduction -- 2. Translational Considerations and Challenges: An Overview -- 3. Considerations for Construct and Affinity Design Goals -- 4. Epitope Characterization and Isotype Selection -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics -- 6. Novel Technologies for Generation of Bispecific Constructs -- 7. Stimulus-Response Mechanisms: An Overview -- 8. Evaluation of Tumor Growth Inhibition in Preclinical Tumor Models: A Quantitative Approach -- 9. Application of Proof-of-Mechanism Biomarkers (POM) in Design and Development of Biologics Modalities -- 10. Antibody Drug Conjugates: Translational Considerations -- 11. Application of PK-PD Modeling and Simulation Approaches for Immuno-Oncology Drugs -- 12. Translational Biomarkers: Application in the Clinical Development of Combination Therapies.
- Format
- e-Book
- Location
- Online
Drug Allergy : Clinical Aspects, Diagnosis, Mechanisms, Structure-Activity Relationships
https://libcat.nshealth.ca/en/permalink/provcat46495
Brian A. Baldo, Nghia H. Pham.
(Second edition)
--Cham:
Springer
, c2021.
- Available Online
- View e-Book
- Access
- NEW Springer 2021
- Location
- Online
The second edition of this book spans the broad range of modern therapeutic drugs, from small molecules to biologic recombinant proteins. It offers a comprehensive review of the classification and description of different drug-induced systemic and cutaneous hypersensitivities; an up-to-date coverage of individual culprit drugs in each group of therapeutics; the diagnosis and mechanisms of reactions; and important structure-activity relationships. New content expands to two areas of drug allergy…
- Available Online
- View e-Book
- Author
- Baldo, Brian A.
- Other Authors
- Pham, Nghia H.
- Responsibility
- Brian A. Baldo, Nghia H. Pham
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2021
- Physical Description
- 1 online resource (xxii, 732 p.) : 330 illus., 162 illus. in color
- ISBN
- 9783030517403
- 9783030517397 (Print ed.)
- 9783030517410 (Print ed.)
- 9783030517427 (Print ed.)
- Subjects (MeSH)
- Drug Hypersensitivity
- Drug-Related Side Effects and Adverse Reactions
- Structure-Activity Relationship
- Specialty
- Allergy and Immunology
- Pharmacology
- Toxicology
- Abstract
- The second edition of this book spans the broad range of modern therapeutic drugs, from small molecules to biologic recombinant proteins. It offers a comprehensive review of the classification and description of different drug-induced systemic and cutaneous hypersensitivities; an up-to-date coverage of individual culprit drugs in each group of therapeutics; the diagnosis and mechanisms of reactions; and important structure-activity relationships. New content expands to two areas of drug allergy that have recently experienced explosive growth: biological therapies and new targeted chemotherapies. Other new and expanded chapters address antimicrobials; drugs used in anesthesia and surgery; opioids; non-targeted anti-cancer drugs; vaccines; and newly understood reaction mechanisms. This new edition includes photographs of a wide variety of cutaneous manifestations that will be of use to other clinicians as well as allergists and dermatologists. In addition to its wide clinical emphasis, the book’s mechanistic and structure-activity detail will provide valuable background for researchers and investigators in universities, medical research institutes, drug companies, and regulatory agencies. The second edition of Drug Allergy is an essential reference for practitioners across the medical disciplines from specialist clinicians, surgeons, GPs, residents, and medical students to nurses, pharmacists, dentists, and those taking undergraduate and graduate courses in the biomedical sciences.
- Contents
- 1. Scope of this Book: Adverse Reactions to Drugs and Drug Allergy -- 2. Classification and Descriptions of Allergic Reactions to Drugs -- 3. Mechanisms of Hypersensitivity -- 4. Diagnosis of Allergic Reactions to Drugs -- 5. ß-Lactam Antibiotics -- 6. Other Antimicrobial Drugs -- 7. Drugs and Other Agents Used in Anesthesia and Surgery -- 8. Opioid Analgesic Drugs -- 9. Non-steroidal Anti-inflammatory Drugs -- 10. Contrast Media -- 11. Corticosteroids -- 12. Proton Pump Inhibitors -- 13. Biologics: Monoclonal Antibodies for Non-cancer Therapy, Cytokines, Fusion Proteins, Enzymes, and Hormones -- 14. Targeted Drugs for Cancer Therapy: Small Molecules and Monoclonal Antibodies -- 15. Non-targeted Drugs for Cancer Therapy -- 16. Vaccines.
- Access
- NEW Springer 2021
- Format
- e-Book
- Location
- Online
Experimental Acupuncturology
https://libcat.nshealth.ca/en/permalink/provcat42547
Jaung-Geng Lin, editor.
--Singapore:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book focuses on the use of acupuncture as a possible and alternative treatment in analgesia, drug addiction, depression, itchiness, peripheral nerve regeneration, stroke, diabetes, cognitive deficits and sleep regulation. Formal recognition by WHO and UNESCO concerning the use and efficacy of acupuncture science in modern medicine has encouraged high levels of investment and commitment to research and development activities into acupuncture science from several top-level health science res…
- Available Online
- View e-Book
- Other Authors
- Lin, Jaung-Geng
- Responsibility
- Jaung-Geng Lin, editor
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (x, 210 p.) : 29 illus., 24 illus. in color
- ISBN
- 9789811309717
- 9789811309700 (print ed.)
- 9789811309724 (print ed.)
- Subjects (MeSH)
- Acupuncture
- Specialty
- Complementary Therapies
- Abstract
- This book focuses on the use of acupuncture as a possible and alternative treatment in analgesia, drug addiction, depression, itchiness, peripheral nerve regeneration, stroke, diabetes, cognitive deficits and sleep regulation. Formal recognition by WHO and UNESCO concerning the use and efficacy of acupuncture science in modern medicine has encouraged high levels of investment and commitment to research and development activities into acupuncture science from several top-level health science research and treatment institutes in China Mainland, Taiwan, Japan, Korea, France and the USA. This book aims to provide direction and guidance on how the medical community can proceed with acupuncturology in modern medical treatment and precision medicine.
- Contents
- 1. A Brief History of Acupuncture: From Traditional Acupuncturology to Experimental Acupuncturology -- 2. Acupuncture Analgesia for Animals -- 3. Electroacupuncture for the Treatment of Morphine and Cocaine Addiction -- 4. Acupuncture Treatment in Depression -- 5. Acupuncture and Itch: Basic Research Aspects -- 6. Effects of Acupuncture on Peripheral Nerve Regeneration -- 7. The Effect of Acupuncture on Stroke -- 8. Experimental Study of Electroacupuncture Therapy in Diabetes Mellitus -- 9. Experimental Models for Mechanistic Studies of Moxibustion -- 10. Acupuncture Elicits Neuroprotective Effect by Ameliorating Cognitive Deficits -- 11. Acupuncture on Sleep Regulation -- 12. High-Tech Acupuncture Research: Laser Acupuncture -- 13. Acupuncture Regulation of Gastrointestinal Function by Selection of Homotopic and Heterotopic Acupoints.
- Format
- e-Book
- Location
- Online
Festschrift, The Institute of Nuclear Medicine, 50 Years
https://libcat.nshealth.ca/en/permalink/provcat31159
University College NHS Foundation Trust, University College London.
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
The Institute of Nuclear Medicine, founded in 1961, celebrates with this Festschrift, its Golden Jubilee. It has been a remarkable 50 years of progress of the radionuclide tracer methodology. From initial, physiology based experimentation, a full independent medical discipline evolved, and with it, a comprehensive clinical service. Diagnosis and Treatment with radiotracers have established the basis for Nuclear Medicine. Technological advances have permeated the field like none other, its multi…
- Available Online
- View e-Book
- Corporate Author
- University College NHS Foundation Trust
- University College London
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (approx. 280 p. : 60 ill., 20 ill. in color)
- ISBN
- 9783642251238
- Subjects (MeSH)
- Academies and Institutes - history
- Radiopharmaceuticals - history
- Nuclear Medicine - history
- Subjects (LCSH)
- Radiology, Medical
- Nuclear medicine
- Other Subjects
- University College, London. Institute of Nuclear Medicine
- Other Subjects
- England
- Abstract
- The Institute of Nuclear Medicine, founded in 1961, celebrates with this Festschrift, its Golden Jubilee. It has been a remarkable 50 years of progress of the radionuclide tracer methodology. From initial, physiology based experimentation, a full independent medical discipline evolved, and with it, a comprehensive clinical service. Diagnosis and Treatment with radiotracers have established the basis for Nuclear Medicine. Technological advances have permeated the field like none other, its multidisciplinary character and its translational research are embedded in the history of the Institute and its success. Recent and latest advances in the field promise a future as bright as has been witnessed and documented in the last 50 years.
- Format
- e-Book
- Location
- Online
Getting to Good : Research Integrity in the Biomedical Sciences
https://libcat.nshealth.ca/en/permalink/provcat42644
Arthur L. Caplan, Barbara K. Redman, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book represents the first comprehensive, gold standard reader on research integrity in the biomedical sciences. Now more than ever, the responsible conduct of research (RCR) has become critically important as new technologies affect research practices in both positive and negative ways. Since learning to do science and practicing it brings researchers into contact with a vast array of ethical issues, it is critical to know the standards and how they are evolving. Indeed, research integrity…
- Available Online
- View e-Book
- Other Authors
- Caplan, Arthur L.
- Redman, Barbara K.
- Responsibility
- Arthur L. Caplan, Barbara K. Redman, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xi, 583 p.) : 488 illus., 298 illus. in color
- ISBN
- 9783319513584
- 9783319513577 (print ed.)
- 9783319513591 (print ed.)
- Subjects (MeSH)
- Biomedical Research - ethics
- Ethics, Research
- Publishing - ethics
- Abstract
- This book represents the first comprehensive, gold standard reader on research integrity in the biomedical sciences. Now more than ever, the responsible conduct of research (RCR) has become critically important as new technologies affect research practices in both positive and negative ways. Since learning to do science and practicing it brings researchers into contact with a vast array of ethical issues, it is critical to know the standards and how they are evolving. Indeed, research integrity requires scientists at all levels to operate ethically in a system that supports ethical practice. This unique, foundational text covers all the relevant areas -- subject protection, research misconduct and conflict of interest as well as newly quantified concerns about research bias and non-reproducibility, as well as other unique issues. Developed by renowned experts, this compelling title discusses the full range of practices and policies that should support research that is honestly produced and disseminated. It also specifically incorporates topics noted by the National Institutes of Health as essential and required for training in RCR. Getting to Good—Research Integrity in the Biomedical Sciences is a major contribution to the literature on bioethics and will serve as an invaluable resource for all researchers, students, administrators and professionals interested in research ethics and integrity.
- Contents
- 1. Methodology -- 2. Policy -- 3. Reproducibility -- 4. Human Subjects Protection -- 5. Responsible Authorship -- 6. Mentor-Mentee Responsibilities and Relationships -- 7. Plagarism -- 8. Peer Review -- 9. Research Misconduct -- 10. Whistleblowing -- 11. Confict of Interest -- 12. Date Acquisition, Management and Transparency -- 13. International Research Involving Resource-Constrained Countries -- Appendix: Montreal Statement on Research Integrity in Cross-Boundary Research Collaborations, 2013.
- Format
- e-Book
- Location
- Online
Health Services Research
https://libcat.nshealth.ca/en/permalink/provcat44875
Justin B. Dimick, Carrie C. Lubitz, editors.
(Second edition)
--Cham:
Springer
, c2020.
- Available Online
- View e-Book
- Holdings
- Cape Breton Regional: 2002 - 2007.
- Location
- Online
This updated volume provides insight into health services research, as well as the emerging areas of research and the tools required to perform scientific work. The book covers topics related to performance assessment, quality improvement, health care policy, and career development. New chapters on the evaluation of non-technical skills in surgery, methods of enhancing causal inference in observational studies, and writing scientific manuscripts are also included. Health Services Research aims …
- Available Online
- View e-Book
- Other Authors
- Dimick, Justin B.
- Lubitz, Carrie C.
- Responsibility
- Justin B. Dimick, Carrie C. Lubitz, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2020
- Holdings
- Cape Breton Regional: 2002 - 2007.
- Physical Description
- 1 online resource (vii, 376 p.) : 55 illus., 38 illus. in color
- Series Title
- Success in academic surgery
- ISBN
- 9783030283575
- 9783030283568 (Print ed.)
- 9783030283582 (Print ed.)
- ISSN
- 0017-9124
- Subjects (MeSH)
- Health Services Research - methods
- Specialty
- Health Services Administration
- Research
- Abstract
- This updated volume provides insight into health services research, as well as the emerging areas of research and the tools required to perform scientific work. The book covers topics related to performance assessment, quality improvement, health care policy, and career development. New chapters on the evaluation of non-technical skills in surgery, methods of enhancing causal inference in observational studies, and writing scientific manuscripts are also included. Health Services Research aims to give advice on how to obtain National Institutes of Health funding and other grants, as well as breaking through the barriers to developing a career in academic surgery. This book is relevant to surgical residents and young surgical faculty, as well as anyone undertaking a career in academic surgery.
- Contents
- Part I. Main Research Areas -- 1. An Introduction to Health Services Research -- 2. Comparative Effectiveness Research -- 3. Understanding Variations in the Use of Surgery -- 4. Health Policy Research in Surgery -- 5. Surgical Disparities: Beyond Non-Modifiable Patient Factors -- 6. Measuring Surgical Quality -- 7. Using Data for Local Quality Improvement -- Part II. Emerging Areas of Research -- 8. Dissemination and Implementation Science -- 9. Studying Organizational Culture in Surgery -- 10. Patient Reported Outcomes in Surgical Research -- 11. Studying What Happens in the Operating Room -- 12. Evaluating Non-Technical Skills in Surgery -- 13. Collaborative Quality Improvement -- 14. Machine Learning and Artificial Intelligence -- Part III. Tools of the Trade -- 15. Large Databases Used for Outcomes Research -- 16. Methods for Enhancing Causal Inference in Observational Studies -- 17. Systematic Review and Meta-Analysis: A Clinical Exercise -- 18. Medical Decision-Making Research in Surgery -- 19. Decision Analysis and Cost-Effectiveness Research -- 20. Survey Research -- 21. Qualitative Research Methods -- Part IV Career Development -- 22. Writing Scientific Manuscripts -- 23. Disseminating Research and #VisualAbstracts -- 24. Engaging Policymakers to Disseminate Research -- 25. Being a Good Mentee in Outcomes Research -- 26. Finding a Mentor -- 27. What Every Outcomes Research Fellow Should Learn -- 28. Funding Opportunities for Outcomes Research -- 29. Principles of Writing K and R Grants -- 30. Choosing Your First Job as a Surgeon and Health Services Researcher -- 31. Building a Health Services Research Program.
- Format
- e-Book
- Location
- Online
Hypertension and Stroke : Pathophysiology and Management
https://libcat.nshealth.ca/en/permalink/provcat40114
Venkatesh Aiyagari, Philip B. Gorelick, editors.
(Second edition)
--Cham:
Springer International Publishing : Imprint: Humana Press
, c2016.
- Available Online
- View e-Book
- Location
- Online
The second edition of this work continues to address the intimate pathophysiologic relationship between hypertension and stroke. The editors and authors clearly and concisely synthesize our developing knowledge of this relationship and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of o…
- Available Online
- View e-Book
- Other Authors
- Aiyagari, Venkatesh
- Gorelick, Philip B
- Responsibility
- Venkatesh Aiyagari, Philip B. Gorelick, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer International Publishing : Imprint: Humana Press
- Date of Publication
- c2016
- Physical Description
- 1 online resource (xix, 353 p. : 46 illus., 18 illus. in color)
- Series Title
- Clinical hypertension and vascular diseases
- ISBN
- 9783319291529
- 9783319291505 (print ed.)
- Subjects (MeSH)
- Antihypertensive Agents - therapeutic use
- Cerebrovascular Disorders - prevention & control
- Hypertension - physiopathology
- Hypertension - therapy
- Stroke - prevention & control
- Abstract
- The second edition of this work continues to address the intimate pathophysiologic relationship between hypertension and stroke. The editors and authors clearly and concisely synthesize our developing knowledge of this relationship and place epidemiologic and physiologic information into a practical clinical context. Comprehensive chapters present the evidence supporting strategies for stroke prevention and care, including blood pressure lowering therapies, anti-coagulation, and management of other cerebrovascular risk factors. In addition to prescriptive measures for first stroke prevention, the book illuminates current regimens for care immediately after acute stroke and for the prevention of recurrent stroke. This latest edition also features extensively updated chapters from the previous edition, as well as new chapters on the effects of hypertension and stroke on the cerebral vasculature, blood pressure management in subarachnoid hemorrhage, and blood pressure variability, antihypertensive therapy, and stroke risk. Written by experts in the field, Hypertension and Stroke: Pathophysiology and Management, Second Edition is of great utility for specialists in neurology and cardiovascular medicine and a valuable practical resource for all physicians caring for older adults and hypertensive patients. .
- Contents
- Blood Pressure: Definition, Diagnosis, and Management -- The Link Between Hypertension and Stroke: Summary of Observational Epidemiological Studies -- Blood Pressure Control and Primary Prevention of Stroke: Summary of Clinical Trial Data -- Mechanisms Underlying Essential Hypertension: Neurogenic and Non-neurogenic -- The Effects of Hypertension and Stroke on the Cerebral Vasculature -- Pathophysiology and Mechanisms Whereby Hypertension May Cause Stroke -- Cardiovascular Risk Assessment, Summary of Guidelines for the Management of Hypertension and a Critical Appraisal of the 2014 Expert Panel of the National Institutes of Health Report -- Acute Blood Pressure Management After Ischemic Stroke -- Hypertensive Encephalopathy, Posterior Reversible Encephalopathy Syndrome, and Eclampsia -- Acute Blood Pressure Management After Intracerebral Hemorrhage -- Blood Pressure Management in Subarachnoid Hemorrhage: The Role of Blood Pressure Manipulation in Prevention of Rebleeding and the Management of Vasospasm -- Recurrent Stroke Prevention I: Diuretic and Angiotensin-Converting Enzyme Inhibitors (ACEIs): The PROGRESS Trial -- Blood Pressure Variability, Antihypertensive Therapy and Stroke Risk -- A Review of Antihypertensive Drugs and Choosing the Right Antihypertensive for Recurrent Stroke Prevention -- Vascular Cognitive Impairment and Alzheimer Disease: Are These Disorders Linked to Hypertension and Other Cardiovascular Risk Factors? -- Hypertension, Cerebral Small Vessel Disease, and Cognitive Function -- Cerebral Microbleeds, Small-Vessel Disease of the Brain, Hypertension and Cognition -- Neuroimaging of Hypertension and Related Cerebral Pathology.
- Format
- e-Book
- Location
- Online
Laparoscopic Cholecystectomy : an Evidence-based Guide
https://libcat.nshealth.ca/en/permalink/provcat34023
Ferdinando Agresta, Fabio Cesare Campanile, Nereo Vettoretto, editors.
--Cham, Switzerland:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This book, written by expert surgeons, offers a comprehensive and up-to-date overview of all aspects of laparoscopic cholecystectomy. Coverage includes the indications for surgery, anesthesia, establishment of pneumoperitoneum, surgical technique, and the prevention and management of complications. Performance of laparoscopic cholecystectomy in the specific contexts of biliary tree stones and acute cholecystitis is described. Extensive reference is made to the latest clinical evidence, and the …
- Available Online
- View e-Book
- Other Authors
- Agresta, Ferdinando
- Campanile, Fabio Cesare
- Vettoretto, Nereo
- Responsibility
- Ferdinando Agresta, Fabio Cesare Campanile, Nereo Vettoretto, editors
- Place of Publication
- Cham, Switzerland
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xvi, 185 pages)
- ISBN
- 9783319054070 (electronic bk.)
- 9783319054063
- Subjects (MeSH)
- Cholecystectomy, Laparoscopic
- Evidence-Based Medicine
- Gallbladder Diseases - surgery
- Subjects (LCSH)
- Cholecystectomy
- Laparoscopic surgery
- Abstract
- This book, written by expert surgeons, offers a comprehensive and up-to-date overview of all aspects of laparoscopic cholecystectomy. Coverage includes the indications for surgery, anesthesia, establishment of pneumoperitoneum, surgical technique, and the prevention and management of complications. Performance of laparoscopic cholecystectomy in the specific contexts of biliary tree stones and acute cholecystitis is described. Extensive reference is made to the latest clinical evidence, and the real benefits of the laparoscopic approach, for example in terms of outcomes and day surgery, are carefully assessed. New technologies, including SILS, NOTES, robotic surgery, and miniaturized instruments, are reviewed. The learning curve and training are also extensively discussed, and an individual chapter is devoted to the views of international experts in the field. Some 20 years after the National Institutes of Health Consensus Conference first published recommendations regarding indications for laparoscopic cholecystectomy, it remains the gold standard approach and continues to evolve.
- Contents
- Laparoscopic Cholecystectomy: Besides the Evidence (What Is Really Done In the World) -- Operative Strategies in Laparoscopic Cholecystectomy: Is There Any Evidence? -- Indications to Laparoscopic Cholecystectomy -- Biliary Tree Stones -- Laparoscopy and Acute Cholecystitis: The Evidence -- Number of Trocars, Types of Dissection, Exploration of Bile Duct, Drainage and Analgesia -- Complications: How to Prevent and Manage Them -- New Technologies -- Real Benefits of the Laparoscopic Approach -- Laparoscopic Cholecystectomy in Day Surgery -- Laparoscopic Cholecystectomy: Training, Learning Curve, and Definition of Expert -- The Expert Opinion: An International Audit -- Establishing Pneumoperitoneum: What Is the Safest Technique for Pneumoperitoneum? -- Anesthetic Management for Laparoscopic Cholecystectomy.
- Format
- e-Book
- Location
- Online
Molecular imaging and contrast agent database (MICAD)
https://libcat.nshealth.ca/en/permalink/provcat34332
National Center for Biotechnology Information.
--Bethesda, MD:
National Institutes of Health
- Available Online
- View Database
- Location
- Online
- Available Online
- View Database
- Corporate Author
- National Center for Biotechnology Information
- Alternate Title
- MICAD
- Place of Publication
- Bethesda, MD
- Publisher
- National Institutes of Health
- Format
- Database
- Location
- Online
Pediatric and Congenital Cardiac Care. Volume 1, Outcomes Analysis
https://libcat.nshealth.ca/en/permalink/provcat38901
Paul R. Barach, Jeffery P. Jacobs, Steven E. Lipshultz, Peter C. Laussen, editors.
--London:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This book is the first in a two-volume set of textbooks and focuses on outcomes analysis in pediatric cardiac care, supporting the coverage of quality improvement and patient safety in its sister title. There has been a huge research effort undertaken in pediatric and congenital cardiac care to understand and measure what is done, to establish collaborative definitions and tools of measurement, and to determine robust benchmarks and methodologies to analyze outcomes. This book concentrates on i…
- Available Online
- View e-Book
- Other Authors
- Barach, Paul R
- Jacobs, Jeffery P
- Lipshultz, Steven E
- Laussen, Peter C
- Responsibility
- Paul R. Barach, Jeffery P. Jacobs, Steven E. Lipshultz, Peter C. Laussen, editors
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xxii, 515 p. : 100 illus., 52 illus. in color)
- ISBN
- 9781447165873
- 9781447165866 (print ed.)
- Subjects (MeSH)
- Data Collection
- Heart Diseases - therapy
- Outcome Assessment, Health Care
- Quality Improvement
- Statisitics as Topic
- Abstract
- This book is the first in a two-volume set of textbooks and focuses on outcomes analysis in pediatric cardiac care, supporting the coverage of quality improvement and patient safety in its sister title. There has been a huge research effort undertaken in pediatric and congenital cardiac care to understand and measure what is done, to establish collaborative definitions and tools of measurement, and to determine robust benchmarks and methodologies to analyze outcomes. This book concentrates on implementation science in terms of continuous quality improvements and safety science and systems. Pediatric and Congenital Cardiac Care: Volume 1, Outcomes Analysis reveals the remarkable developments that have been seen in the fields of pediatric cardiology and cardiac surgery. This unique collaboration between four Editors from disparate medical disciplines (cardiac surgery, cardiology, anesthesia, and critical care) incorporates an international community of scholarship with articles by luminaries and cutting edge thinkers on the current and future status of pediatric and congenital cardiac care. The goal of this and its companion volume is to understand and advance the profession and its activities, to use common terms, and to improve the management of risk and safety in order to enhance pediatric and congenital cardiac care.
- Contents
- Part I Introduction -- 1 Introduction -- 2 Introduction: The History of Statistics in Medicine and Surgery -- 3 Introduction: Using Data to Drive Change and Improvement: The Legacy of Florence Nightingale -- 4 Introduction: Quality Improvement and Databases in the Context of Professionalism -- Part II Nomenclature and Taxonomies -- 5 Nomenclature for Congenital and Pediatric Cardiac Disease: Historical Perspectives and the International Pediatric and Congenital Cardiac -- 6 Defining Terms in Lists of Nomenclature -- 7 Illustrating Terms in Lists of Nomenclature -- Part III Databases 8 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Cardiac Surgery -- 9 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Cardiology -- 10 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Anesthesia -- 11 Databases for Assessing the Outcomes of the Treatment of Patients with Congenital and Pediatric Cardiac Disease: The Perspective of Critical Care -- 12 Early Database Initiatives: The Fyler Codes -- 13 The Academic Database: Lessons Learned from the Congenital Heart Surgeons’ Society Data Center -- 14 Clinical Versus Administrative Data -- 15 Databases for Pediatric Cardiac Transplantation: The United Network for Organ Sharing/Scientific Registry of Transplant Recipients (UNOS/SRTR) and the Pediatric Heart Transplant Study (PHTS) -- 16 Databases for Extracorporeal Membrane Oxygenation and Ventricular Assist Devices -- 17 The United Kingdom National Congenital Heart Disease Audit -- 18 The Pediatric Cardiac Care Consortium: The End of an Era and Beginning of a New Mission -- 19 Pediatric Cardiac Catheterization Databases -- 20 Pediatric Electrophysiology Databases -- 21 Using Data to Drive Improvement and Build the Science of Nursing -- 22 Data Standards of the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) and the Universal Pediatric Cardiac Dataset -- 23 Ethical Issues Confronting Outcomes Analysis and Quality Assurance -- Part IV Stratification of Complexity -- 24 Statistical Issues in the Analysis and Interpretation of Outcomes for Congenital Cardiac Surgery -- 25 Real Time Monitoring of Risk- Adjusted Surgical Outcomes for Congenital Heart Disease -- 26 Risk Adjustment for Congenital Heart Surgery -1 (RACHS-1) for Evaluation of Mortality in Children Undergoing Cardiac Surgery -- 27 The Aristotle Complexity Score: A Tool to Evaluate Performance in Congenital Heart Surgery -- 28 Empirically Based Tools for Analyzing Mortality and Morbidity Associated with Congenital Heart Surgery -- Part V Verifi cation of Data Completeness and Accuracy of Data -- 29 Verification of Data Completeness and Accuracy -- Part VI Subspecialty Collaboration -- 30 Linking Databases -- Part VII Longitudinal Follow-Up -- 31 Use of National Death Registries to Empower Databases in Reporting Longitudinal Follow-Up -- 32 Quality of Life: The Need for a National Database -- 33 Longitudinal Follow-Up Studies in the Pediatric Heart Network -- 34 The Value of National Institutes of Health (NIH) Registry-Based Research in Identifying Childhood Cardiac Disease Outcomes: The Pediatric Cardiomyopathy Registry Experience -- Part VIII Public Reporting of Data -- 35 Public Reporting of Cardiac Data: Pros, Cons, and Lessons for the Future -- 36 Public Reporting of Pediatric Cardiac Data -- 37 Communication Chaos: How Incomplete and Conflicting Information Prevents Improved Outcomes for Patients with Pediatric and Congenital Cardiac Disease (and What We Can Do About It) -- Index.
- Format
- e-Book
- Location
- Online
--Bethesda, MD:
US National Library of Medicine | National Institutes of Health
- Available Online
- View Database
- Location
- Online
- Available Online
- View Database
- Place of Publication
- Bethesda, MD
- Publisher
- US National Library of Medicine
- National Institutes of Health
- Notes
- Access to this online resource is restricted to IWK Health Centre employees working from inside the hospital network.
- Format
- Database
- Location
- Online
Success in academic surgery : health services research
https://libcat.nshealth.ca/en/permalink/provcat34037
Justin B. Dimick, Caprice C. Greenberg, editors.
--London:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
Success in Academic Surgery: Health Services Research is a unique handbook which will help researchers and surgeons in obtaining National Institutes of Health funding and other grants, as well as breaking through the barriers to developing a career in academic surgery. Aimed at surgical residents and young surgical faculty, Success in Academic Surgery: Health Services Research is written by expert authors from around the world who are members of the Association for Academic Surgery, and it offe…
- Available Online
- View e-Book
- Other Authors
- Dimick, Justin B.
- Greenberg, Caprice C.
- Responsibility
- Justin B. Dimick, Caprice C. Greenberg, editors
- Alternate Title
- Health services research
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xv, 292 pages)
- Series Title
- Success in academic surgery
- ISBN
- 9781447147183 (electronic bk.)
- 9781447147176
- Subjects (MeSH)
- General Surgery
- Health Services Research
- Outcome Assessment, Health Care
- Quality Assurance, Health Care
- Surgical Procedures, Operative
- Subjects (LCSH)
- Surgery - Research
- Abstract
- Success in Academic Surgery: Health Services Research is a unique handbook which will help researchers and surgeons in obtaining National Institutes of Health funding and other grants, as well as breaking through the barriers to developing a career in academic surgery. Aimed at surgical residents and young surgical faculty, Success in Academic Surgery: Health Services Research is written by expert authors from around the world who are members of the Association for Academic Surgery, and it offers a practical and personal insight on working in academic surgery.
- Contents
- Part I. Main Research Areas -- An Introduction to Health Services Research -- Comparative Effectiveness Research -- Understanding Variations in the Use of Surgery -- Health Policy Research in Surgery -- Studying Surgical Disparities: It's Not All Black and White -- Measuring Health Care Quality in Surgery: Strategies, Limitations, and Currently Available Initiatives -- Using Data for Local Quality Improvement -- Part II. Emerging Areas of Research -- Implementation Science and Quality Improvement -- Understanding and Changing Organizational Culture in Surgery -- Assessing Patient-Centered Outcomes -- Studying What Happens in the OR -- Collaborative Quality Improvement -- Part III. Tools of the Trade -- Large Databases Used for Outcomes Research -- Methods for Enhancing Causal Inference in Observational Studies -- Systematic Review and Meta-analysis: A Clinical Exercise -- Medical Decision-Making Research in Surgery -- Survey Research -- Qualitative Research Methods -- Part IV. Career Development -- Engaging Students in Surgical Outcomes Research -- Finding a Mentor in Outcomes Research -- What Every Outcomes Research Fellow Should Learn -- Funding Opportunities for Outcomes Research -- Choosing Your First Job as a Surgeon and Health Services Researcher -- Building a Health Services Research Program.
- Format
- e-Book
- Location
- Online
Translating National Policy to Improve Environmental Conditions Impacting Public Health Through Community Planning
https://libcat.nshealth.ca/en/permalink/provcat43201
Beth Ann Fiedler, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This first-of-its-kind volume traces rarely explored links between public policy, the state of the environment, and key issues in public health, with recommendations for addressing longstanding intractable problems. Experts across diverse professions use their wide knowledge and experience to discuss hunger and food sustainability, land use, chronic and communicable diseases, child mortality, and global water quality. Interventions described are varied as well, from green technology breakthroug…
- Available Online
- View e-Book
- Other Authors
- Fiedler, Beth Ann
- Responsibility
- Beth Ann Fiedler, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xi, 312 p.) : 30 illus., 27 illus. in color
- ISBN
- 9783319753614
- 9783319753607 (print ed.)
- 9783319753621 (print ed.)
- Subjects (MeSH)
- Environmental Policy
- Health Policy
- Public Health
- Social Planning
- Specialty
- Environmental Health
- Policy
- Public Health
- Abstract
- This first-of-its-kind volume traces rarely explored links between public policy, the state of the environment, and key issues in public health, with recommendations for addressing longstanding intractable problems. Experts across diverse professions use their wide knowledge and experience to discuss hunger and food sustainability, land use, chronic and communicable diseases, child mortality, and global water quality. Interventions described are varied as well, from green technology breakthroughs to regulatory accountability, innovative urban planning and community policing programs. Chapters build and expand on each other's themes inspiring deeper understanding and critical thinking that further prompts readers to develop practical solutions leading to improvements in planetary and population health outcomes. Included in the coverage: The challenge of implementing macroeconomic policy in an increasingly microeconomic world; Green aid flows: trends and opportunities for developing countries; Planning healthy communities: abating preventable chronic diseases; Foundations of community health: planning access to public facilities; International changes in environmental conditions and their personal health consequences. Translating National Policy to Improve Environmental Conditions Impacting Public Health is developed for educators, students, and policymakers to generate awareness and review options to help create change in their communities. Federal agencies such as the Department of Health and Human Services, the National Institutes of Health, the EPA, and Housing and Urban Development will also find it salient.
- Contents
- 1. The Challenge of Implementing Macroeconomic Policy in an Increasingly Microeconomic World -- 2. Green Aid Flows: Trends and Opportunities for Developing Countries -- 3. Food Sustainability Index Report on the United States: The Good, the Bad, and the Ugly -- 4. Planning Healthy Communities: Abating Preventable Chronic Diseases -- 5. A Regulatory Primer of International Environmental Policy and Land Use -- 6. A Regulatory Primer of United States Multisectoral Land Use and Environmental Policy -- 7. Foundations of Community Health: Planning Access to Public Facilities -- 8. Food Reservations at the Reservation? -- 9. The Buzz About Restoring Mother Nature at the Urban Core -- 10. Green Business: Not Just the Color of Money -- 11. Upstream Policy Recommendations for Pakistan’s Child Mortality Problem -- 12. Water Quality: Mindanao Island of the Philippines -- 13. International Changes in Environmental Conditions and Their Personal Health Consequences -- 14. Streetwise Community Policing to Inform United States National Policy.
- Format
- e-Book
- Location
- Online
Uterine Cancer : Diagnosis and Treatment
https://libcat.nshealth.ca/en/permalink/provcat39502
Shalini Rajaram, Chitrathara K, Amita Maheshwari, editors.
(1st ed.)
--New Delhi:
Springer India
, c2015.
- Available Online
- View e-Book
- Location
- Online
Uterine cancers are the commonest malignancies of the female genital tract in the developed world, and are increasing in numbers world over because of obesity and other life-style changes. Many of these malignancies are hereditary and thus, a better understanding of the genetic and molecular biology is needed. This would lead to appropriate treatment plan for improving the quality of life and long-term survival. This book addresses, in depth, all aspects of uterine malignancies covering both ca…
- Available Online
- View e-Book
- Other Authors
- Rajaram, Shalini
- K, Chitrathara
- Maheshwari, Amita
- Responsibility
- Shalini Rajaram, Chitrathara K, Amita Maheshwari, editors
- Edition
- 1st ed.
- Place of Publication
- New Delhi
- Publisher
- Springer India
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xvi, 459 p. : 144 illus., 105 illus. in color)
- ISBN
- 9788132218920
- 9788132218913 (print ed.)
- Subjects (MeSH)
- Uterine Neoplasms - diagnosis
- Uterine Neoplasms - therapy
- Abstract
- Uterine cancers are the commonest malignancies of the female genital tract in the developed world, and are increasing in numbers world over because of obesity and other life-style changes. Many of these malignancies are hereditary and thus, a better understanding of the genetic and molecular biology is needed. This would lead to appropriate treatment plan for improving the quality of life and long-term survival. This book addresses, in depth, all aspects of uterine malignancies covering both carcinomas and sarcomas. The book is divided into seven sections; the first two sections deal with epidemiology, molecular aspects, familial cancers and pathology and the later sections focus on diagnosis, imaging techniques and comprehensive management of both early stage and advanced cancers. Surgical techniques, adjuvant chemotherapy and radiotherapy have been covered in detail. Apart from the open surgical methods, role of laparoscopy and emerging role of robotic surgery in the contemporary management of endometrial cancers have been discussed. Written by authors with expertise in the field of gynecologic oncology from premier institutes, this book provides up-to-date information on best practice management of uterine malignancies.
- Contents
- Part I. Epidemiology, Molecular Biology, Familial Endometrial Cancer, Screening, Diagnosis and Staging -- 1. Epidemiology of Endometrial Cancers and Uterine Sarcomas -- 2. Molecular Pathology and Cytogenetics of Endometrial Carcinoma, Carcinosarcoma, and Uterine Sarcomas -- 3. Hereditary Cancers of the Endometrium: HNPCC Syndrome and Beyond -- 4. Screening and Prevention of Carcinoma Endometrium -- 5. Clinical Evaluation of Abnormal Uterine Bleeding -- 6. Risk Factors, Diagnosis, and Staging of Endometrial Cancer -- 7. Imaging in Uterine Malignancy: Role of Ultrasonography, CT, and PET-CT -- 8. Magnetic Resonance Imaging in Endometrial Cancer -- Part II. Pathology of Uterine Cancers 9. Steroid Receptors in Normal Endometrium and in Endometrial Cancer -- 10. Pathology of Endometrial Hyperplasia and Carcinoma -- 11. Pathology of Uterine Sarcomas -- 12. Prognostic and Predictive Factors in the Management of Carcinoma Endometrium -- Part III. Surgical Anatomy and Early Stage Endometrial Cancer -- 13. Surgical Anatomy of the Uterus -- 14. Endometrial Cancer Staging -- 15. Sentinel Node Evaluation in Endometrial Cancer -- 16. Surgery for Carcinoma Endometrium -- 17. Ovarian Preservation in Endometrial Carcinoma -- 18. The Role of Lymphadenectomy in Endometrial Cancer: The Mayo Clinic Experience -- 19. Extraperitoneal Laparoscopic Para-aortic Lymphadenectomy in Endometrial Cancer: Rationale and Surgical Technique -- 20. Role of Laparoscopic and Robotic Surgery in Endometrial Cancer: The Inevitable Evolution -- 21. Basics of Robotic Instrumentation and Robotic-Assisted Surgery for Endometrial Cancer -- 22. Adjuvant Radiation in Early-Stage Endometrial Cancer: Evidence, Principles, and Techniques -- 23. Therapeutic Options for Early- Stage Uterine Papillary Serous Carcinomas, Carcinosarcomas, and Clear-Cell and Mixed-Cell Histologies -- 24. Chemotherapy for High-Risk Early- Stage Endometrial Cancer: Current Evidence -- 25. Diagnosis and Management of Stage II Endometrial Cancer -- 26. Posttreatment Surveillance in Endometrial Cancer -- Part IV. Advanced Stage and Recurrent Endometrial Cancer -- 27. Surgery for Advanced Endometrial Cancer -- 28. Systemic Treatment of Advanced Endometrial Carcinoma -- 29. Therapeutic Strategies in Recurrent and Metastatic Endometrial Cancer -- Part V. Uterine Sarcomas -- 30. Uterine Sarcomas: Risk Factors, Clinical Presentation, Diagnosis, and Staging -- 31. Surgical Management of Uterine Sarcoma -- 32. Role of Radiation Therapy in Uterine Sarcoma -- 33. Role of Systemic Therapy in the Management of Uterine Sarcomas.-- 34. Surveillance of Uterine Sarcomas -- Part VI. Special Case Scenarios -- 35. Metabolic Syndrome and Endometrial Cancer -- 36. Management of Incompletely Staged Endometrial Cancer -- 37. Synchronous Cancers of the Ovary and Endometrium -- 38. Smooth Muscle Tumors of Uncertain Malignant Potential of Uterine Origin -- 39. Endometrial Cancers in Young Women: Conservative Management and Fertility Preserving Options -- 40. Hormone Therapy in Normal Postmenopausal Women and After Treatment for Endometrial Cancer -- 41. Effects of Tamoxifen and Other SERMs in the Endometrium and Follow-Up of Patients -- Part VII. Palliative Care -- 42. Palliative Care and End of Life Options for Patients with Endometrial Cancer.
- Format
- e-Book
- Location
- Online
