Atlas of neuromuscular diseases : a practical guideline
https://libcat.nshealth.ca/en/permalink/provcat33272
Eva L. Feldman, Wolfgang Grisold, James W. Russell, Wolfgang Löscher.
(Second edition)
--Heidelberg:
Springer
, c2014.
- Available Online
- View e-Book
- Location
- Online
This atlas presents a comprehensive outline of neuromuscular diseases, written by respected American and European authors. It discusses all aspects of neuromuscular disorders including cranial and spinal nerves, motor neuron diseases, nerve plexus, peripheral nerves, mono- and polyneuropathies, entrapment syndromes, neuromuscular junctions, and muscle disease. Each chapter is structured into the following sections: anatomy, symptoms, signs, pathogenesis, diagnosis and differential diagnosis, th…
- Available Online
- View e-Book
- Author
- Feldman, Eva L
- Other Authors
- Grisold, Wolfgang
- Russell, James W
- Loescher, Wolfgang
- Responsibility
- Eva L. Feldman, Wolfgang Grisold, James W. Russell, Wolfgang Löscher
- Edition
- Second edition
- Place of Publication
- Heidelberg
- Publisher
- Springer
- Date of Publication
- c2014
- Physical Description
- 1 online resource (xxi, 320 pages)
- ISBN
- 9783709116050 (electronic bk.)
- 9783709116043
- Subjects (MeSH)
- Neuromuscular Diseases - Handbooks
- Subjects (LCSH)
- Neuromuscular diseases - Atlases
- Abstract
- This atlas presents a comprehensive outline of neuromuscular diseases, written by respected American and European authors. It discusses all aspects of neuromuscular disorders including cranial and spinal nerves, motor neuron diseases, nerve plexus, peripheral nerves, mono- and polyneuropathies, entrapment syndromes, neuromuscular junctions, and muscle disease. Each chapter is structured into the following sections: anatomy, symptoms, signs, pathogenesis, diagnosis and differential diagnosis, therapy and prognosis. The diagnostic tools in neuromuscular disease are explained and practical guidelines are offered on how to advance from symptoms to syndromes. The therapeutic options for each disease are also described. In this new edition, the structure of the chapters has been reorganized and chapters on principles of peripheral nerves, nerve pain, nerve surgery and rehabilitation have been added. The current trend of increased use of imaging techniques such as US and MRI in the diagnosis and follow-up of neuromuscular disorders is also reflected
- Contents
- Principles of peripheral nerves -- Diagnostic tools -- Principles of peripheral nerve surgery -- Principles of nerve rehabilitation -- Pain -- Cranial nerves -- Roots -- Plexus -- Mononeuropathies -- Nerve tumours -- Polyneuropathies -- Conditions resembling mononeuropathies -- Neuromuscular transmission disorders -- Muscle -- Motor neuron diseases
- Format
- e-Book
- Location
- Online
Clinical physiology : an examination primer
https://libcat.nshealth.ca/en/permalink/provcat27224
Banerjee, Ashis.
--Cambridge, UK:
Cambridge University Press
, 2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Banerjee, Ashis
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- 2005
- Physical Description
- 363 p.
- ISBN
- 6610223661
- Subjects (MeSH)
- Physiological Phenomena
- Contents
- Cover -- Half-title -- Title -- Copyright -- Table of Contents -- Preface -- 1 Cell physiology -- Introduction -- Cell membrane -- Structure of cell membranes -- Membrane proteins -- Classification of cell membrane receptors -- Intercellular junctions -- Types of intercellular junctions -- Cell adhesion molecules -- Cell membrane transport -- Classification of transport mechanisms -- Ion channels -- Subcellular organelles -- Nucleus -- Endoplasmic reticulum -- Golgi apparatus -- Mitochondria -- Lysosomes -- Peroxisomes (microbodies) -- Cytoskeleton -- Cell polarity -- Bibliography -- Recommended Further reading -- 2 Water and electrolyte balance -- Water balance -- Mechanisms of water homeostasis -- Osmolality and tonicity -- Components of extracellular fluid -- Water reabsorption -- Properties of arginine vasopressin (antidiuretic hormone; ADH) -- Sodium -- Physiological role of sodium -- Sodium homeostasis -- Potassium -- Functions of potassium -- Potassium balance -- Magnesium -- Functions of magnesium -- Hypomagnesaemia -- Bibliography -- 3 Acid...base balance -- Introduction -- The pH scale -- Bronsted...Lowry definitions -- Factors affecting body acid...base balance -- Buffers -- A scheme for the assessment and management of acid...base abnormalities -- Bibliography -- 4 Renal physiology -- Introduction to renal structure -- Functional components of the kidneys -- Functions of the kidney -- Excretory and regulatory -- Metabolic -- Endocrine -- The renal circulation -- Effects of renal circulation on urine production -- Autoregulation -- Processes involved in urine production -- Glomerular filtration -- Tubular function -- Natriuretic peptides -- Glomerular balance -- Loop of Henle -- Renal function tests -- Tests of glomerular filtration -- Tests of renal tubular function -- Renal blood flow measurement -- Diuretics -- Classes of diuretics -- Micturition -- Micturition cycle -- Urodynamic assessment of micturition -- Bibliography -- 5 Temperature regulation -- Introduction -- Thermoregulatory mechanism -- Mechanisms of heat loss to the environment -- Heat response -- Cold response -- Heat production -- Sources of body heat production -- Measurement of body heat production -- Hypothermia -- Effects of hypothermia -- Fever -- Pathogenesis of fever -- 6 Cardiovascular system -- Introduction -- The fetal circulation -- Control of blood volume -- Blood volume control mechanism -- Effects of blood loss -- Blood pressure -- Factors regulating blood pressure -- Valsalva manoeuvre -- Measurement of arterial blood pressure -- Renin...angiotensin mechanism -- Pathway for renin...angiotensin mechanism -- Effects of angiotensin II -- Pharmacological manipulation of the renin...angiotensin mechanism -- Cardiac output -- Determinants of cardiac output -- Meas
- Format
- e-Book
- Location
- Online
Glutamine in clinical nutrition
https://libcat.nshealth.ca/en/permalink/provcat33651
Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, editors.
--New York:
Humana Press
, c2015.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Other Authors
- Rajendram, Rajkumar
- Preedy, Victor R
- Patel, Vinood B
- Responsibility
- Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, editors
- Place of Publication
- New York
- Publisher
- Humana Press
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xxxiv, 551 pages)
- Series
- Nutrition and Health
- Series Title
- Nutrition and health (Totowa, N.J.)
- ISBN
- 9781493919321 (electronic bk.)
- 9781493919314
- Subjects (MeSH)
- Glutamine - therapeutic use
- Nutritional Physiological Phenomena
- Subjects (LCSH)
- Glutamine
- Diet therapy
- Contents
- Part I. Basic Processes at the Cellular Level and in Animal Models -- 1. Glutamine structure and function: a starter pack -- 2. Amino acid transporters and glutamine -- 3. Role of glutamine transaminases in nitrogen, sulfur, selenium and 1-carbon metabolism -- 4. Glutamine uptake and immunomodulation: an overview - Kenneth Frauwirth -- 5. The role of glutamine and glutamic acid in the pituitary gland involvement in thyroid-stimulating hormone release -- 6. Glucose-independent glutamine-driven TCA cycle in cancer cells -- 7. The role of glutamine synthetase in the glutamine independence in mammary tissue -- 8. Glutamine addiction of cancer cells -- 9. L-[5-11C]-glutamine and metabolic imaging in cancer cells -- 10. Endotoxemia and glutamine -- Part II. Glutamine Use in Critically Ill Patients and Their Diagnosis -- 11. Plasma glutamine and its levels in metabolic stress -- 12. Glutamine supplementation in major surgery and intensive care -- 13. Enteral nutrition supplemented with L-glutamine in patients with sepsis -- 14. Glutamine supplementation in multiple trauma patients -- 15. Glutamine dipeptide and insulin sensitivity in critically ill patients -- 16. Potential for glutamine supplementation in critically ill children -- 17. Glutamine and ammonia in hepatic encephalopathy -- 18. The oral glutamine challenge in liver cirrhosis -- Part III. Glutamine in Normal Metabolism and under Surgical Stress -- 19. Insulin secretion and the glutamine-glutamate-alpha-ketoglutarate axis -- 20. Glutamine-cycling pathway in metabolic syndrome: Systems Biology-Based Characterization of the glutamate-related metabotype and advances for Diagnosis and Treatment in Translational Medicine -- 21. Glutamine and glucagon-like peptide-1 response -- 22. Glutamine pretreatment and surgery for cleft lip/cleft palate in children -- 23. Use of perioperative glutamine dipeptide in parenteral nutrition in surgical hospital patients with malnutrition -- 24. Therapeutic use of glutamine for diabetic foot ulcers and related conditions -- Part IV. Clinical Aspects of Glutamine in the Intestine -- 25. Glutamine protects GI epithelial tight junctions -- 26. Glutamine therapy in colitis models -- 27. Glutamine supplementation and Helicobacter pylori infection -- 28. Small intestinal hypoxic injury and use of arginyl-glutamine dipeptide: applications to pediatrics -- 29. Dipeptide-bound glutamine and the intestinal microcirculation in cancer -- Part V. Clinical Aspects of Glutamine in Certain Patient Populations -- 30. Manganese toxicity and the glutamine-glutamate cycle -- 31. Glutamine and epilepsy -- 32. Glutamine supplementation in glutamine synthetase deficiency -- 33. Plasma antioxidants and glutamine supplementation in HIV -- 34. Glutamine, total antioxidant systems and damage in renal ischemia reperfusion injury -- 35. Protection by glutamine after ischemia/reperfusion injury -- 36. Glutamine and cancer immunosuppression -- 37. Combining exercise with glutamine-supplementation in cancer cachexia metabolism -- 38. Glutamine and skeletal muscle -- 39. Glutamine and myostatin expression in muscle wasting -- 40. Web based resources, and suggested readings.
- Format
- e-Book
- Location
- Online
Molecular and Functional Insights Into the Pulmonary Vasculature
https://libcat.nshealth.ca/en/permalink/provcat42841
Kaushik Parthasarathi, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
- Available Online
- View e-Book
- Other Authors
- Parthasarathi, Kaushik
- Responsibility
- Kaushik Parthasarathi, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vi, 86 p.) : 7 illus., 6 illus. in color
- Series Vol.
- 228
- Series Title
- Advances in anatomy, embryology and cell biology
- ISBN
- 9783319684833
- 9783319684826 (print ed.)
- 9783319684840 (print ed.)
- ISSN
- 0301-5556
- Specialty
- Pulmonary Medicine
- Abstract
- This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.
- Contents
- Transcription Factors Regulating Embryonic Development of Pulmonary Vasculature -- Regulation of Intercellular Junctions in the Pulmonary Vasculature -- Mitochondria-dependent Signaling in the Pulmonary Vasculature -- Leukocyte-Endothelial Interactions in the Pulmonary Vasculature -- Apoptotic Mechanisms in the Pulmonary Vasculature.
- Format
- e-Book
- Location
- Online
Oral Mucosa in Health and Disease : A Concise Handbook
https://libcat.nshealth.ca/en/permalink/provcat43279
Lesley Ann Bergmeier, editor.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique microflora and homeostatic interaction with the innate and adaptive immune responses. As an immune tissue the oral mucosa was somewhat neglected in the past owi…
- Available Online
- View e-Book
- Other Authors
- Bergmeier, Lesley Ann
- Responsibility
- Lesley Ann Bergmeier, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xi, 184 p.) : 54 illus., 45 illus. in color
- ISBN
- 9783319560656
- 9783319560649 (print ed.)
- 9783319560663 (print ed.)
- Subjects (MeSH)
- Mouth Diseases
- Mouth Mucosa - immunology
- Oral Manifestations
- Specialty
- Oral Health
- Abstract
- This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique microflora and homeostatic interaction with the innate and adaptive immune responses. As an immune tissue the oral mucosa was somewhat neglected in the past owing to the tendency to assume similarity to the gut mucosa. More recently it has become apparent that the oral mucosa is a complex environment and, like the esophageal mucosa, has more in common with vaginal tissue than with the gut. Furthermore, the ability of the oral mucosa to act as an immune inductive site has made it an attractive area of research in terms of desensitization for allergic reactions and possibly autoimmune responses. In this book, recognized experts in the field provide up-to-date coverage of all aspects of the structure and function of the oral mucosa, reflecting important recent advances in knowledge, including at the molecular level.
- Contents
- 1. Structure and Functions of the Oral Mucosa -- 2. Cell-Cell Interactions in the Oral Mucosa: Tight Junctions and Gap Junctions -- 3. Anchoring Junctions in the Oral Mucosa: Adherens Junctions and Desmosomes -- 4. Immunology of the Oral Mucosa -- 5. Mucosal Homeostasis of the Oral Mucosa -- 6. Wound Healing in the Oral Mucosa -- 7. Saliva and Gingival Crevicular Fluid: Contributions to Mucosal Defense -- 8. Oral Cancer: Recent Developments and Future Challenges -- 9. Epigenetics in the Oral Cavity -- 10. Infections of the Oral Mucosa and Immune Responses -- 11. Non-infectious Diseases of the Oral Mucosa: The Importance of Immune Functions -- 12. Clinical Management of Oral Mucosal Disease: A Literature Review -- 13. Future Directions of Research in the Oral Mucosa.
- Format
- e-Book
- Location
- Online
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement : Drug Manipulation Strategies and Vehicle Effects
https://libcat.nshealth.ca/en/permalink/provcat39433
Nina Dragicevic, Howard I. Maibach, editors.
--Berlin, Heidelberg:
Springer
, c2015.
- Available Online
- View e-Book
- Location
- Online
This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse phy…
- Available Online
- View e-Book
- Other Authors
- Dragicevic, Nina
- Maibach, Howard I
- Responsibility
- Nina Dragicevic, Howard I. Maibach, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2015
- Physical Description
- 1 online resource (xvi, 341 p. : 118 illus., 38 illus. in color)
- Series Title
- Percutaneous penetration enhancers
- ISBN
- 9783662450130
- 9783662450123 (print ed.)
- Subjects (MeSH)
- Administration, Cutaneous
- Drug Delivery Systems
- Skin Absorption - drug effects
- Skin - drug effects
- Abstract
- This truly comprehensive reference, in a mini-series format with five volumes, offers a detailed description of both well-known and recently introduced methods for percutaneous penetration enhancement. The first three volumes are devoted to the broad range of chemical methods used to enhance the skin delivery of drugs, including the vast variety of chemical penetration enhancers, drug and vehicle manipulation strategies, nanocarriers, and many others. The fourth volume discusses the diverse physical methods used in penetration enhancement, such as sonophoresis, iontophoresis, electroporation, microporation, laser ablation, and microneedles. Determination of drug penetration is covered in the final volume, with a focus especially on mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. This edition of Percutaneous Penetration Enhancers will be an invaluable resource for researchers, pharmaceutical scientists, practitioners, and also students.
- Contents
- [publisher supplied] THE SKIN -- The Skin Structure And Penetration Pathways Through The Skin -- The Increasing Importance Of The Follicular Route In Dermal And Transdermal Drug Delivery -- The Importance Of SC Lipid Organization For Skin Barrier Function -- Nanostructure Of The Epidermal Extracellular Space Investigated By Cryo-Electron Microscopy And Tomography -- The Correlation Between Transepidermal Water Loss And Percutaneous Drug Absorption -- Influence Of Excipients On The Stratum Corneum Lipids And Epidermal Tight Junctions -- PENETRATION ENHANCEMENT TECHNIQUES IN SKIN DELIVERY -- Classification Of Penetration Enhancement Techniques -- DRUG MANIPULATION STRATEGIES IN PENETRATION ENHANCEMENT -- Selection Of A Proper Prodrug For Penetration Enhancement -- Supersaturated Solutions For Penetration Enhancement -- Eutectic Systems For Penetration Enhancement -- INFLUENCE OF VEHICLE EFFECTS IN PENETRATION ENHANCEMENT -- Dermal and Transdermal Formulations -- EMULSIONS (AS SKIN DELIVERY SYSTEMS) AS VEHICLES FOR SKIN DELIVERY -- GELS AS VEHICLES FOR SKIN DELIVERY.
- Format
- e-Book
- Location
- Online
Principles of Renal Physiology
https://libcat.nshealth.ca/en/permalink/provcat30984
Christopher J. Lote.
(5th ed.)
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
A good knowledge of renal physiology is essential to the understanding of many disease states. The purpose of the book is to set out the principles of renal physiology and normal renal function. Now in its 30th year of continuous publication, this new edition offers a logical progression through renal physiology and pathophysiology. In addition, the anatomy, physiology, pharmacology and pathology of the kidney are covered, making it highly suitable for system based courses. This 5th edition h…
- Available Online
- View e-Book
- Author
- Lote, Christopher J
- Responsibility
- Christopher J. Lote
- Edition
- 5th ed.
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xv, 204 p. : 78 ill., 31 ill. in color)
- ISBN
- 9781461437857
- Subjects (MeSH)
- Kidney - physiology
- Renal Circulation - physiology
- Subjects (LCSH)
- Human physiology
- Nephrology
- Abstract
- A good knowledge of renal physiology is essential to the understanding of many disease states. The purpose of the book is to set out the principles of renal physiology and normal renal function. Now in its 30th year of continuous publication, this new edition offers a logical progression through renal physiology and pathophysiology. In addition, the anatomy, physiology, pharmacology and pathology of the kidney are covered, making it highly suitable for system based courses. This 5th edition has been extensively revised and features a wealth of new and widely accepted information about kidney function. This includes our understanding of the role of the glycocalyx and structural proteins in glomerular filtration; details of tubular transport, tight junctions and paracellular transport; and an update of the loops of Henle functioning. Principles of Renal Physiology, 5th Edition is a concise and easily readable text ideal for undergraduate medical and medical science students.
- Contents
- The Body Fluids -- Essential Anatomy of the Kidney -- Glomerular Filtration -- Tubular Transport -- The Proximal Tubule -- The Loop of Henle, Distal Tubule and Collecting Duct -- Renal Blood Flow and Glomerular Filtration Rate -- Regulation of Body Fluid Osmolality -- Regulation of Body Fluid Volume -- Renal Regulation of Body Fluid pH -- Renal Control of Body Fluid Potassium Content -- Renal Regulation of Body Calcium, Magnesium and Phosphate -- Summary of the Principle Reabsorptive and Secretory Processes in the Nephron Segments -- Disease Conditions Which Alter Renal Sodium and Water Reabsorption -- Use of Diuretics.
- Format
- e-Book
- Location
- Online
Therapeutic Intranasal Delivery for Stroke and Neurological Disorders
https://libcat.nshealth.ca/en/permalink/provcat44465
Jun Chen, Jian Wang, Ling Wei, John H. Zhang, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
The blood-brain-barrier prevented harmful materials entering the brain and in the meantime is a barricade to therapeutic drug delivery. Intranasal drug delivery to circumvent blood-brain-barrier was developed in the past, to take advantages of a secret passage from the olfactory epithelium into the brain—bypassing the tight junctions that encapsulated the brain from blood circulation. This timely publication of Therapeutic Intranasal Delivery for Stroke and Neurological Disorders presented some…
- Available Online
- View e-Book
- Other Authors
- Chen, Jun
- Wang, Jian
- Wei, Ling
- Zhang, John H.
- Responsibility
- Jun Chen, Jian Wang, Ling Wei, John H. Zhang, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (vi, 153 p.) : 11 illus., 8 illus. in color
- Series Title
- Springer series in translational stroke research
- ISBN
- 9783030167158
- 9783030167134 (Print ed.)
- 9783030167141 (Print ed.)
- ISSN
- 2363-958X
- Subjects (MeSH)
- Blood-Brain Barrier - drug effects
- Capillary Permeability - physiology
- Drug Administration Routes
- Nervous System Diseases - drug therapy
- Stroke - drug therapy
- Specialty
- Neurology
- Pharmacology
- Abstract
- The blood-brain-barrier prevented harmful materials entering the brain and in the meantime is a barricade to therapeutic drug delivery. Intranasal drug delivery to circumvent blood-brain-barrier was developed in the past, to take advantages of a secret passage from the olfactory epithelium into the brain—bypassing the tight junctions that encapsulated the brain from blood circulation. This timely publication of Therapeutic Intranasal Delivery for Stroke and Neurological Disorders presented some of the latest advances in intranasal delivery research, including transnasal hypothermia induction, stem cell intranasal transplantation, intranasal drug delivery in ischemic and hemorrhagic models, intranasal peptides delivery, intranasal tPA application in adults and children. Editors Jun Chen, Jian Wang, Ling Wei and John Zhang are professors from University of Pittsburgh, Johns Hopkins University, Emory University and Loma Linda University in USA.
- Contents
- 1. Transnasal Induction of Therapeutic Hypothermia for Neuroprotection -- 2. Hypoxia-Primed Stem Cell Transplantation in Stroke -- 3. Therapeutic Potential of Intranasal Drug Delivery in Preclinical Studies of Ischemic Stroke and Intracerebral Hemorrhage -- 4. Intranasal Drug Delivery after Intracerebral Hemorrhage -- 5. Intranasal Treatment in Subarachnoid Hemorrhage -- 6. Intranasal Delivery of Therapeutic Peptides for Treatment of Ischemic Brain Injury -- 7. Intranasal Delivering Method in the Treatment of Ischemic Stroke -- 8. Intranasal Delivery of Drugs for Ischemic Stroke Treatment: Targeting IL-17A -- 9. Intranasal tPA Application for Axonal Remodeling in Rodent Stroke and Traumatic Brain Injury Models -- 10. Therapeutic Intranasal Delivery for Alzheimer’s Disease -- 11. Intranasal Medication Delivery in Children for Brain Disorders.
- Format
- e-Book
- Location
- Online
Treatment of Dry Skin Syndrome : The Art and Science of Moisturizers
https://libcat.nshealth.ca/en/permalink/provcat31172
Marie Lodén, Howard I. Maibach, editors.
--Berlin, Heidelberg:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Dry skin impacts on the lives of many individuals but in most cases it can be adequately managed with current moisturizing products. Certain moisturizers, however, can themselves adversely affect the quality of life by inducing further dryness and eczema and so becoming addictive. In addition, there is a possible link between moisturizing treatments and asthma. Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the…
- Available Online
- View e-Book
- Other Authors
- Lodén, Marie
- Maibach, Howard I
- Responsibility
- Marie Lodén, Howard I. Maibach, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxxvii, 591 p. : 145 ill., 50 ill. in color)
- ISBN
- 9783642276064
- Subjects (MeSH)
- Dermatitis - drug therapy
- Emollients - therapeutic use
- Skin Care
- Skin Diseases - drug therapy
- Subjects (LCSH)
- Dermatology
- Biochemistry
- Abstract
- Dry skin impacts on the lives of many individuals but in most cases it can be adequately managed with current moisturizing products. Certain moisturizers, however, can themselves adversely affect the quality of life by inducing further dryness and eczema and so becoming addictive. In addition, there is a possible link between moisturizing treatments and asthma. Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.
- Contents
- [Machine generated contents note] Pt. I Marketplace and Treatment Aspects -- 1. Moisturizers as Cosmetics, Medicines, or Medical Device? The Regulatory Demands in the European Union / Marie Loden -- 2. Design of Claims Support for Moisturizers / Judith K. Woodford -- 3. Educational Interventions for the Management of Children with Dry Skin / Noreen Heer Nicol -- 4. Dry Skin in Childhood and the Misery of Eczema and Its Treatments / Susan Lewis-Jones -- 5. Use of Moisturizers in Patients with Atopic Dermatitis / Alexander K.C. Leung -- Pt. II Skin Essentials -- 6. Sensory Systems of Epidermal Keratinocytes / Mitsuhiro Denda -- 7. Sensitive Skin: Intrinsic and Extrinsic Contributors / Michael K. Robinson -- 8. Electron Tomography of Skin / Lars Norlen -- 9. Filaggrin Gene Defects and Dry Skin Barrier Function / Jacob P. Thyssen -- 10. Molecular Organization of the Lipid Matrix in Stratum Corneum and Its Relevance for the Protective Functions of Human Skin / Mila Boncheva -- 11. Desquamation: It Is Almost All About Proteases / Anthony V. Rawlings -- 12. Endogenous Retroviral-Like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization / Takeshi Matsui -- 13. Vernix Caseosa and Its Substitutes: Lipid Composition and Physicochemical Properties / Steven B. Hoath -- 14. Role of Tight Junctions and Aquaporins in Skin Dryness / J.M. Brandner -- 15. Biomechanics of the Barrier Function of Human Stratum Corneum / Reinhold H. Dauskardt -- Pt. III Dry Skin Disorders and Treatments -- 16. Update on Atopic Eczema with Special Focus on Dryness and the Impact of Moisturizers / Eric Simpson -- 17. Update on Hand Eczema with Special Focus on the Impact of Moisturisers / Mark Wilkinson -- 18. Update on Ichthyosis with Special Emphasis on Dryness and the Impact of Moisturizers / Johannes Wohlrab -- 19. Psoriasis and Dry Skin: The Impact of Moisturizers / Razvigor Darlenski -- 20. Update on Infant Skin with Special Focus on Dryness and the Impact of Moisturizers / Neena K. Tierney -- Pt. IV Ingredients and Treatment Effects -- 21. Composition and Development of Moisturizers / Steve Barton -- 22. Ungual Formulations: Topical Treatment of Nail Diseases / Kenneth A. Walters -- 23. Preservation of Moisturisers / D. Godfrey -- 24. Potential Allergens in Moisturizing Creams / An Goossens -- 25. Formulating Moisturizers Using Natural Raw Materials / Swarnlata Saraf -- 26. Chemical and Physical Properties of Emollients / Jari T. Alander -- 27. Polyfunctional Vehicles by the Use of Vegetable Oils / Chiara Andolfatto -- 28. Effect of Natural Moisturizing Factors on the Interaction Between Water Molecules and Keratin / Noriaki Nakagawa -- 29. Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin / David W. Koenig -- 30. Water and Minerals in the Treatment of Dryness / Lawrence Charles Parish -- 31. Hyaluronan Inside and Outside of Skin / Robert Stern -- 32. Glycerol as a Skin Barrier Influencing Humectant / Fabrice Pirot -- 33. Use of Urea in the Treatment of Dry Skin / Marie Loden -- 34. Urea and Skin: A Well-Known Molecule Revisited / Susanne Grether-Beck -- 35. Influence of Climate on the Treatment of Dry Skin with Moisturizer / E. Proksch -- 36. Emollient Therapy and Skin Barrier Function / Majella E. Lane -- 37. Skin Barrier Responses to Moisturizers: Functional and Biochemical Changes / Izabela Buraczewska-Norin -- 38. Changes in Stratum Corneum Thickness, Water Gradients and Hydration by Moisturizers / Joseph R. Kaczvinsky -- 39. Skin Moisture and Heat Transfer / Lee Berk.
- Format
- e-Book
- Location
- Online
Tumor Angiogenesis : A Key Target for Cancer Therapy
https://libcat.nshealth.ca/en/permalink/provcat44567
edited by Dieter Marmé.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not a…
- Available Online
- View e-Book
- Other Authors
- Marmé, Dieter
- Responsibility
- edited by Dieter Marmé
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource
- Series Title
- Springer reference
- ISBN
- 9783319312156
- Subjects (MeSH)
- Angiogenesis Inhibitors - therapeutic use
- Neovascularization, Pathologic - physiology
- Neovascularization, Pathologic - therapy
- Neoplasms - blood supply
- Neoplasms - therapy
- Specialty
- Medical Oncology
- Molecular Medicine
- Notes
- "Living reference work."
- Abstract
- Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.
- Contents
- Angiopoietins and TIE Receptors in Lymphangiogenesis and Tumor Metastasis -- Anti-Angiogenic Cancer Therapy: Development of Resistance -- Anti-Angiogenic Targeting in Metastatic Colorectal Cancer Therapy -- Anti-Angiogenic Targets: Angiopoietin and Angiopoietin-Receptors -- Anti-Angiogenics and Radiation Therapy -- Anti-Angiogenics in Gastroesophageal Cancer -- Anti-Angiogenics in Hepatocellular Cancer Therapy -- Anti-angiogenics in Kidney Cancer Therapy -- Anti-Angiogenics in Pancreatic Cancer Therapy -- Antiangiogenics in Brain Metastases: Perspectives and Experiences -- Benefits and Pitfalls of Tumor Vessel Normalization -- Biomarkers for Anti-angiogenic Therapy -- Combination of Antiangiogenics and Other Targeted Therapies -- Controlling Vascular Permeability: How Does It Work and What Is the Impact on Normal and Pathological Angiogenesis -- Cytotoxics and Anti-Angiogenics: Metronomic Therapies -- Endothelial Cell-Cell Junctions in Tumor Angiogenesis -- Imaging Tumor Angiogenesis -- Inhibition of Tumor Angiogenesis in GIST Therapy -- Inhibition of Tumor Angiogenesis in the Treatment of Lung Cancer -- Mechanisms of Anti-Angiogenic Therapy -- Mechanisms of Tumor Angiogenesis -- Pathology of Tumor Angiogenesis -- Significance and Molecular Regulation of Lymphangiogenesis in Cancer -- The Impact of Endothelial Transcription Factors in Sprouting Angiogenesis -- The Implication of Antiangiogenic Treatment of Malignancies on Human Metabolism -- The Role of the VEGF Signaling Pathway in Tumor Angiogenesis -- The Role of VEGF in Controlling Vascular Permeability -- The Value of Anti-Angiogenics in Bladder Cancer Therapy -- The Value of Anti-Angiogenics in Cervical Cancer Therapy -- The Value of Anti-Angiogenics in Head and Neck Cancer Therapy -- The Value of Anti-Angiogenics in Multiple Myeloma Therapy -- The Value of Anti-Angiogenics in Ovarian Cancer Therapy -- The Value of Anti-Angiogenics in Primary Brain Tumor Therapy -- The Value of Anti-Angiogenics in Prostate Cancer Therapy -- The Value of Anti-Angiogenics in Soft Tissue Sarcoma Therapy -- The Value of Antiangiogenics in Breast Cancer Therapy.
- Format
- e-Book
- Location
- Online
Visual Dysfunction in Diabetes : The Science of Patient Impairment and Health Care
https://libcat.nshealth.ca/en/permalink/provcat30994
edited by Joyce Tombran-Tink, Colin J. Barnstable, Thomas W. Gardner.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of…
- Available Online
- View e-Book
- Other Authors
- Tombran-Tink, Joyce
- Barnstable, Colin J
- Gardner, Thomas W
- Responsibility
- edited by Joyce Tombran-Tink, Colin J. Barnstable, Thomas W. Gardner
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xv, 379 p. : 72 ill., 51 ill. in color)
- Series Title
- Ophthalmology research
- ISBN
- 9781607611509
- Subjects (MeSH)
- Diabetes Complications
- Diabetic Retinopathy
- Subjects (LCSH)
- Neurosciences
- Endocrinology
- Ophthalmology
- Abstract
- An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutics will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.
- Contents
- Pt. I. Living with diabetic retinopathy -- Living with diabetic retinopathy : the patient's view -- Pt. II. How is diabetic retinopathy detected? -- Diabetic retinopathy screening : progress or lack of progress -- Functional/neural mapping discoveries in the diabetic retina : advancing clinical care with the multifocal ERG -- Pt. III. How does diabetes affect the eye? -- Corneal diabetic neuropathy -- Clinical phenotypes of diabetic retinopathy -- Visual psychophysics in diabetic retinopathy -- Mechanisms of blood-retinal barrier breakdown -- Molecular regulation of endothelial cell tight junctions and the blood-retinal barrier -- Capillary degeneration in diabetic retinopathy -- Proteases in diabetic retinopathy -- Proteomics in the vitreous of diabetic retinopathy patients -- Neurodegeneration in diabetic retinopathy -- Glucose-induced cellular signaling in diabetic retinopathy -- IGFBP-3 as a regulator of the growth-hormone/insulin-like growth factor pathway in proliferative retinopathies -- Neurotrophic factors in diabetic retinopathy -- Role of CTGF in diabetic retinopathy -- Pt. IV. How can vision loss be limited : experimental therapies -- Ranidizumab and other VEGF antagonists for diabetic macular edema -- Neurodegeneration, neuropeptides, and diabetic retinopathy -- Glial cell-derived cytokines and vascular integrity in diabetic retinopathy -- Impact of islet cell transplantation on diabetic retinopathy in type 1 diabetes.
- Format
- e-Book
- Location
- Online
