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Systemic Sclerosis : Basic and Translational Research

https://libcat.nshealth.ca/en/permalink/provcat40403
Kazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana, editors. (1st ed.) --Tokyo: Springer Japan , c2016.
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Location
Online
This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines an…
Available Online
View e-Book
Other Authors
Takehara, Kazuhiko
Fujimoto, Manabu
Kuwana, Masataka
Responsibility
Kazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana, editors
Edition
1st ed.
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (viii, 247 p. : 28 illus., 7 illus. in color)
ISBN
9784431557081
9784431557074 (print ed.)
Subjects (MeSH)
Scleroderma, Systemic
Translational Medical Research
Abstract
This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
Contents
1. Fibrosis: Overview -- 2. Autoimmunity in Systemic Sclerosis: Overview -- 3. Endothelial Progenitor Cells -- 4. Animal Models of Systemic Sclerosis -- 5. Genetics of Systemic Sclerosis -- 6. Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis -- 7. Interleukin-6 in the Pathogenesis of Systemic Sclerosis -- 8. Epigenetics -- 9. Transforming Growth Factor-ß and Connective Tissue Growth Factor -- 10. Endothelin -- 11. The Role of B Cells in Systemic Sclerosis -- 12. Fli1 -- 13. Biomarker -- 14. Autoantibodies in Systemic Sclerosis.
Format
e-Book
Location
Online
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