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Acupuncture and Moxibustion as an Evidence-based Therapy for Cancer

https://libcat.nshealth.ca/en/permalink/provcat31284
William C.S. Cho, editor. --Dordrecht: Springer , c2012.
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Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in narrowing the knowledge…
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Other Authors
Cho, William C.S.
Responsibility
William C.S. Cho, editor
Place of Publication
Dordrecht
Publisher
Springer
Date of Publication
c2012
Physical Description
1 online resource (xi, 354 p. : 25 ill., 18 ill. in color)
Series Vol.
v. 3
Series Title
Evidence-based anticancer complementary and alternative medicine
ISBN
9789400748330
Subjects (MeSH)
Acupuncture Therapy
Evidence-Based Medicine
Moxibustion
Neoplasms - therapy
Subjects (LCSH)
Oncology
Alternative medicine
Acupuncture
Abstract
Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in narrowing the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, an unparalleled undertaking of a book series is launched to structurally consolidate this area. Although acupuncture and moxibustion have been practiced for millennia, they have come under scientific investigation only recently. Acupuncture and moxibustion have been used clinically to treat cancer-related symptoms (e.g. cancer pain, anxiety, depression and insomnia), manage treatment-induced side effects (e.g. hot flashes, nausea and vomiting) and enhance immunity (e.g. blood cell count, lymphocyte and natural killer cell activity). This is the first book manages to provide comprehensive and updated scientific evidence of the effectiveness of acupuncture and moxibustion intervention for cancer care. Laboratory and animal studies have uncovered the mechanisms of acupuncture and moxibustion for cancer therapy. Promising results of most clinical trials show the efficacy and safety of acupuncture and moxibustion in cancer management. This book consists of fifteen chapters which address a range of important aspects that will impact on the application of acupuncture and moxibustion. An overview of the safety and side effects of acupuncture and moxibustion for cancer care are also covered. In addition, the integration of acupuncture with Western medicine in cancer treatment and recent clinical trials are included as well. Opinion leaders around the world have teamed up to pursue a thorough and up-to-date review of the area, this volume will contribute great to the cancer, clinical and academic community by providing evidence-based information on the efficacy of acupuncture and moxibustion as an anticancer therapy.
Contents
Prelims -- 1. An Overview of Acupuncture and Moxibustion for Cancer Care -- 2. The Mechanistic Studies of Acupuncture and Moxibustion -- 3. Acupuncture for Cancer Pain -- 4. Acupuncture for the Treatment of Hot Flashes in Cancer Patients -- 5. Acupuncture and Moxibustion for Cancer-related Symptoms -- 6. Use of Acupuncture and Moxibustion in the Control of Anticancer Therapy-induced Nausea and Vomiting -- 7. Acupuncture and Moxibustion for Side Effects of Chemotherapy in Cancer Patients -- 8. Acupuncture for the Treatment of Symptoms Associated with Radiation Therapy -- 9. Quality of Life of Cancer Patients after Acupuncture and Moxibution Treatment -- 10. Acupuncture and Moxibustion for Palliative and Supportive Cancer Care -- 11. Is Acupuncture or Moxibustion Better Than a Sham or Placebo-treatment?-12. Safety and Side Effects of Acupuncture and Moxibustion as a Therapy for Cancer -- 13. Acupuncture and Moxibustion in Animal Models of Cancer -- 14. Integrating Acupuncture with Western Medicine in Cancer Treatment -- 15. Recent Clinical Trials of Acupuncture for Cancer Patients. Index.
Format
e-Book
Location
Online
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Cancer immunotherapy : immune suppression and tumor growth

https://libcat.nshealth.ca/en/permalink/provcat27591
Pendergast, George C. --Amsterdam, Netherlands: Elsevier Academic Press , 2007.
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Location
Online
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Author
Pendergast, George C
Other Authors
Jaffee, Elizabeth M
Place of Publication
Amsterdam, Netherlands
Publisher
Elsevier Academic Press
Date of Publication
2007
Physical Description
409 p.
ISBN
9780080521855
Subjects (MeSH)
Antineoplastic Agents - therapeutic use
Immunotherapy
Neoplasms - therapy
Contents
Cancer immunoediting: from immune surveillance to immune escape / Ryungsa Kim -- Immunosurveillance: innate and adaptive antitumor immunity / Masahisa Jinushi and Glenn Dranoff -- Cytokine regulation of immune tolerance to tumors / Ming O. Li and Richard A. Flavell -- Immunological sculpting: natural killer cell receptors and ligands / David A. Sallman and Julie Y. Djeu -- Immune escape: immunosuppressive networks / Shuang Wei, Alfred Chang, and Weiping Zou -- Cytotoxic chemotherapy in clinical treatment of cancer / Rajesh Thirumaran, George C. Prendergast, and Paul B. Gilman -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Concepts in pharmacology and toxicology / Richard A. Westhouse and Bruce D. Car -- Cancer immunotherapy: challenges and opportunities / Andrew J. Lepisto, John R. McKolanis, and Olivera J. Finn -- Cancer vaccines / Freda K. Stevenson ... [et al.] -- Immunotherapy and cancer therapeutics: why partner? / Leisha A. Emens and Elizabeth M. Jaffee -- Immune stimulatory features of classical chemotherapy / Robbert G. van der Most, Anna K. Nowak, and Richard A. Lake -- Dendritic cells and coregulatory signals: immune checkpoint blockade to stimulate immunotherapy / Drew Pardoll -- Regulatory T cells in tumor immunity: role of toll-like receptors / Rong-Fu Wang -- Tumor-associated macrophages in cancer growth and progression / Alberto Mantovani, Paola Allavena and Antonio Sica -- Tumor-associated myeloid-derived suppressor cells / Stephanie K. Bunt ... [et al.] -- Programmed death ligand-1 and galectin-1: pieces in the puzzle of tumor-immune escape / Gabriel A. Rabinovich and Thomas F. Gajewski -- Indoleamine 2,3-dioxygenase in immune escape: regulation and therapeutic inhibition / Alexander J. Muller and George C. Prendergast -- Arginase, nitric oxide synthase, and novel inhibitors of L-arginine metabolism in immune modulation / Susanna Mandruzzato, Simone Mocellin, and Vincenzo Bronte.
Format
e-Book
Location
Online
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Damage-Associated Molecular Patterns in Human Diseases : Volume 1. Injury-Induced Innate Immune Responses

https://libcat.nshealth.ca/en/permalink/provcat42536
Walter Gottlieb Land. --Cham: Springer , c2018.
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This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress response…
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Author
Land, Walter Gottlieb
Responsibility
Walter Gottlieb Land
Alternate Title
Injury-induced innate immune responses
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xlviii, 870 p.) : 115 illus., 102 illus. in color
ISBN
9783319786551
9783319786544 (print ed.)
9783319786568 (print ed.)
Subjects (MeSH)
Biomarkers - analysis
Immunologic Techniques
Molecular Medicine
Pathogen-Associated Molecular Pattern Molecules
Stress, Physiological - immunology
Wounds and Injuries - immunology
Specialty
Diagnosis
Molecular Medicine
Pathology
Abstract
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the "danger/injury model" is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
Contents
Part I. The Three Major Paradigms in Modern Immunology -- Prologue: The Term "Immunity" over the Course of Time -- The Three Major Paradigms in Immunology -- Epilogue: What Major Paradigm in Immunology Comes Next? -- Part II. The Innate Immune System: an Organ of Perception Determined to Maintain Homeostasis -- Prologue: The Guardians of Homeostasis -- Innate Immune Recognition Molecules -- Epilogue: The Innate Immune System: a Global Player in Health and Disease -- Part III. The Whole Family of Mammalian Innate Immune Cells -- Prologue: The Whole Body as an Immune System? -- Mobile Innate Immune Cells -- Sessile Innate Immune Cells -- Epilogue: The Whole Body as an Immune Defence System -- Part IV. The World of DAMPs. Prologue: About DAMPs, PAMPs and MAMPs -- Endogenous DAMPs, Category I: Constitutively Expressed Native Molecules (Cat. I DAMPs) -- Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs) -- Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs) -- Exogenous DAMPs, Category IV (Cat. IV DAMPs) -- Epilogue: The Well-Dosed Work of DAMPs in their Commission to Restore and Maintain Homeostasis -- Part V. Cellular Stress Responses and Regulated Cell Death -- Prologue: Innate Immune Tools to Defend against Stressful Injury: Success and Failure -- Cell-Autonomous (Cell-Intrinsic) Stress Responses -- Regulated Cell Death -- Epilogue: The Horror of an Injury-Induced Avalanche of DAMPs -- Part VI. Innate Immune Effector Responses -- Prologue: The Various Facets of Innate Immune Effector Responses -- Cellular Inflammatory Responses -- Humoral Innate Immune Effector Responses -- Regulation of Innate Inflammatory Responses -- Epilogue to Part VI -- Part VII. Function of Innate Lymphoid Cells and Unconventional T Cells with Partial Innate Function -- Prologue: The "Ready-to-Go" Lymphocytes of the Immune System -- Activating and Function of Innate Lymphoid Cells -- Activating and Function of Unconventional T Cells -- Epilogue: Killer Lymphocytes as Tools for Future Immunotherapeutic Approaches -- Part VIII. DAMPs Promoting Adaptive Immunity and Tissue Repair -- Prologue: The "Long Arm" of DAMPs in Shaping Adaptive Immune Responses and Tissue Repairing Processes -- Antigen Uptake, Processing and Presentation by Dendritic Cells -- Antigen in the Presence of DAMPs Induces Immunostimulatory Dendritic Cells to Promote "Destructive" Acquired Immune Responses -- Antigen in the Absence of DAMPs Promotes Immunotolerance: the Role of Dendritic Cells and Regulatory T Cells -- An Impressive Example of Peripheral Tolerance against Nonself: Tolerance to Commensal Bacterial and Dietary Protein Antigens -- Immunometabolism of Dendritic Cells and T Cells -- Role of DAMPs in Tissue Regeneration and Repair -- Epilogue: DAMPs as Key Players in the Pathogenesis of Many Human Diseases.
Format
e-Book
Location
Online
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Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver

https://libcat.nshealth.ca/en/permalink/provcat45410
Ling Zhang, Haipeng Shao, Serhan Alkan, editors. --Cham: Springer , c2020.
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This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal…
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Other Authors
Zhang, Ling
Shao, Haipeng
Alkan, Serhan
Responsibility
Ling Zhang, Haipeng Shao, Serhan Alkan, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xii, 363 p.) : 179 illus., 176 illus. in color
ISBN
9783030377083
9783030377076 (Print ed.)
9783030377090 (Print ed.)
9783030377106 (Print ed.)
Subjects (MeSH)
Hematologic Diseases - diagnosis
Hematologic Neoplasms - diagnosis
Hematopoietic System - pathology
Liver - pathology
Spleen - pathology
Specialty
Pathology
Hematology
Medical Oncology
Abstract
This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists.
Contents
Anatomy and Histology of Normal Liver and Spleen -- Diagnostic Approaches of Hematopoietic Disorders of Spleen and Liver -- Molecular and Genetic Diagnostic Approaches of Hematopoietic Disorders of Spleen and Liver -- Hairy Cell Leukemia, Hairy Cell Leukemia Variant, and Splenic Diffuse Red Pulp Small B-cell Lymphoma -- Splenic Marginal Zone Lymphoma and other Small B-cell Lymphomas -- Primary and Secondary Large Cell Lymphoma of Spleen -- Primary Hepatic B-cell Lymphomas -- Plasma Cell Neoplasm and Amyloidosis in Liver and Spleen -- Hepatosplenic T-cell Lymphoma -- T-cell Large Granular Lymphocytic Leukemia involving Liver and Spleen -- Uncommon Mature T-cell Lymphomas -- Hodgkin Lymphoma in Liver and Spleen -- B-lymphoblastic Leukemia/Lymphoma involving Spleen or Liver -- T-lymphoblastic Leukemia/Lymphoma involving Spleen or Liver -- Aggressive Natural Killer Cell Leukemia and T-Cell Prolymphocytic Leukemia: Two Rare and Highly Aggressive Hematologic Neoplasms Typically Involving Liver and Spleen -- Myeloid Neoplasms in Liver and Spleen -- Histiocytic and Dendritic Cell Disorders in Liver and Spleen -- Transplant Related Disorders in Liver and Spleen -- Benign Red Blood Cell Disorders in Liver and Spleen -- Benign Hematologic Disorders involving Liver and Spleen -- Infectious and Inflammatory Mimickers of Hematopoietic Disorders in Liver and Spleen.
Format
e-Book
Location
Online
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Encyclopedia of AIDS

https://libcat.nshealth.ca/en/permalink/provcat43085
Thomas J. Hope, Douglas D. Richman, Mario Stevenson, editors-in-chief. --New York, NY: Springer , c2018.
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For the first time, the world's experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features over 4,000 A-Z entries including medical, cultural, social, and pharmacological essays. The Pathology entries cover the various types of HIV-related illnesses, including those that are and are not AIDS-defining. Many of the conditions that are AIDS-defining illnesses have their own entries or are cross-referenced to a generic entry in which several related conditions are…
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Other Authors
Hope, Thomas J.
Richman, Douglas D.
Stevenson, Mario
Responsibility
Thomas J. Hope, Douglas D. Richman, Mario Stevenson, editors-in-chief
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (ix, 2192 p.) : 341 illus., 305 illus. in color
Series Title
Springer reference
ISBN
9781493971015
9781493971008 (print ed.)
Subjects (MeSH)
Acquired Immunodeficiency Syndrome
Specialty
Infectious Disease Medicine
Notes
"eReference"--Publisher.
Abstract
For the first time, the world's experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features over 4,000 A-Z entries including medical, cultural, social, and pharmacological essays. The Pathology entries cover the various types of HIV-related illnesses, including those that are and are not AIDS-defining. Many of the conditions that are AIDS-defining illnesses have their own entries or are cross-referenced to a generic entry in which several related conditions are discussed (such as enteric diseases and fungal infections). Typically, the treatment of any given form of pathology is briefly discussed in the entry that covers that illness. The reference is a must-read for Infectious Disease specialists, Immunologists, Public Health researchers, Virologists, Microbiologists, Pharmacologists, and Physicians.
Contents
Abstinence, Be Faithful, Condoms (ABC), Prevention of HIV -- Acetylation -- Actin -- AIDS-related -- Primary Central Nervous System Lymphoma -- Anal Cancer -- Anatomic Compartments as a Barrier to HIV Cure -- Antiretroviral Drug Penetration into Lymphoid Tissue -- Antiretroviral Drug Penetration into the CNS Compartment -- Antiretroviral Medications, Adult Care and Treatment -- Antiretroviral therapy (ART), Prevention of HIV -- Anti-Retroviral Therapy and Drug Resistance in HIV-2 Infection -- Antiretroviral Therapy for HIV-Infected Infants, Children, and Adolescents in Resource-Rich Settings -- Antiretroviral Therapy: When to Start -- Antiretroviral Treatment in Resource-Limited Settings -- APOBEC3F/G and Vif: Action and Counteractions -- Apoptosis Dysregulation during HIV Disease -- Arp2/3 -- Attachment/Binding -- Autophagy and HIV Infection -- Bacterial Respiratory and Invasive Pneumococcal Infections and HIV -- BAF (BANF1) -- Behavioral Aspects of HIV Mother-to-Child Transmission -- Behavioral Aspects of HIV Treatment as Prevention -- Behavioral Interventions for Adherence -- Behavioral Science highlights of evidence and research -- Blood and blood product donors and recipients in China, Epidemiology of HIV/AIDS -- Budding -- Burkitt and Burkitt-like Lymphoma -- Cardiovascular Complications -- cART and Supportive Care for HIV-Associated Malignancies -- Case Management for Linkage -- Cell Intrinsic Immunity -- Cellular and Soluble Immune Activation Markers in HIV-Infected Subjects -- Cellular Cofactors for HIV-1 Transcription -- Cellular Cofactors of HIV as Drug Targets -- Central Memory CD4 T cells -- Cervical Cancer and HIV -- Chagas Disease and HIV -- Children, Care and Treatment -- Children, Epidemiology of HIV/AIDS -- Chronic Immune Activation in HIV -- Circumcision and AIDS -- Clinical Ethics in HIV/AIDS Prevention, Care, and Research -- Cofilin, Trafficking -- Collagen Deposition and Fibrosis in the Lymphatic Tissues of HIV-1 Infected Individuals -- Combination Approaches to HIV Prevention -- Community Viral Load -- Co-morbidity: Opiods -- Comorbidity: Progressive Multifocal Leukoencephalopathy -- Conjunctival Carcinoma -- Counteraction of SAMHD1 by Vpx -- Chromosome Region Maintenance 1 (CRM1) -- Cryptococcosis and HIV -- Cryptosporidiosis -- Epidemic Kaposi Sarcoma, Pathogenesis and Presentation of -- CXCR4, Coreceptors -- Cyclophilin A and HIV-1 Replication -- Cystoisosporiasis -- Cytomegalovirus Infection and HIV -- DDX3, Cofactors, and RNA Export -- Delayed Sexual Debut -- Dendritic Cell Interactions with HIV-1 Envelope Glycoprotein, Implications for Preventing Transmission -- Differential Diagnosis of HIV-Associated Neurocognitive Disorders -- Diffuse Large B-Cell Lymphoma -- Eastern Europe and Central Asia, specific characteristics of HIV/AIDS epidemic -- Elderly: Epidemiology of HIV/AIDS -- Entry Inhibitors -- Epidemiology of AIDS-Defining Malignancies -- Epidemiology of HIV-2 Infection in West Africa -- Epidemiology of Non-AIDS-Defining Malignancies -- Epstein Barr Virus (EBV) -- Faith Based Interventions -- Family Interventions -- Female Condoms -- Female, Male and Transgender Sex Workers, Epidemiology of HIV/AIDS -- Fusion -- Gamma delta T cells -- Global NeuroAIDS -- HAND Adjunctive Therapies: Reversing Neuronal Injury -- Harm Reduction for Injection Drug Users -- Health care workers, Epidemiology of HIV/AIDS -- Health care workers, Shortage and task shifting of -- Hepatitis B Virus infection and HIV -- Hepatitis C Virus Infection and HIV -- Hepatocellular Carcinoma in HIV-Positive Patients -- History of the AIDS epidemic -- HIV "auxiliary" proteins, essential role of -- HIV & SIV, CD4 T cell responses to -- HIV and Opportunistic Infections, an Overview -- HIV and Sexual Violence -- HIV and SIV, B-Cell Responses to -- HIV and SIV, CD8 T Cell Responses to -- HIV Antigen Processing and Presentation -- HIV Associated Immune Exhaustion -- HIV Cancers in Resource-Limited Regions -- HIV Compartments and Viral Rebound During Treatment Interruption -- HIV Coreceptor Tropism in Different Reservoirs -- HIV Counseling and Testing, Prevention of HIV -- HIV Funding agencies and major programs -- HIV Infection, Immune-based Interventions for -- HIV Life Cycle: Overview -- HIV Neurocognitive Diagnosis, Natural History and Treatment -- HIV Prevention and African Americans -- HIV Prevention and Asians and Pacific Islanders -- HIV Prevention and Hispanics -- HIV Prevention and Labor Migration -- HIV Prevention and Women -- HIV Prevention Efforts Within Substance Use Disorder Treatment Settings -- HIV Prevention for MSM -- HIV Prevention for Serodiscordant Couples -- HIV Prevention for Stimulant Using Men Who have Sex with Men -- HIV Prevention in Persons 50 and Older -- HIV Prevention in the Correctional System -- HIV Prevention in Transgender Persons -- HIV Prevention in Youth -- HIV Reservoirs in Lymph Nodes and Spleen -- HIV Reservoirs in the Central Nervous System -- HIV Reservoirs Within the Lungs -- HIV Testing and Counseling -- HIV Transmission in Female Commercial Sex Workers and Host Protective Factors -- HIV-1 Assembly Cofactors -- HIV-1 Maturation -- HIV-1 Mutational Escape from Host Immunity -- HIV-1 Pathogenesis in the Gut -- HIV-1 Pre-Exposure Prophylaxis -- HIV-1 Prevention Using Live-attenuated Vaccines -- HIV-1 Rev Expression and Functions -- HIV-1 Transmission Blocking Microbicides -- HIV-1 Transmission; Influence of Bodily Secretions -- HIV-1 Virion Structure -- HIV-2 Diagnosis and Viral Load Measurements -- HIV-2 Envelope: Structure, Diversity and Evolution -- HIV-2 Infection in Europe, Epidemiology of -- HIV-2 Infection: The Role of Immune Activation in Pathogenesis -- HIV-2 Neurological Manifestations -- HIV-2 Transmission -- HIV-2: Lessons from the Dakar Cohort -- HIV-Associated Cancers -- Hodgkin Lymphoma in Patients with HIV Infection -- Host Genetics and Genomics -- Housing as HIV Prevention -- Human Papillomavirus (HPV) -- Identification and Validation of HIV Cofactors -- Identifying Opportunities to Block HIV-1 Transmission in the Female Genital Tract -- Immune Activation and HIV Transmission -- Immunogenetics of HIV-2 Infection -- Immunological Responses to Antiretroviral Therapy -- Immunology of Latent HIV Infection -- Immunopathogenesis of HIV Co-infections -- Inflammasome and HIV -- Inflammatory Cytokines -- Inhibition of HIV-1 Spread: Cell-Free Versus Cell-Cell -- Initial Antiretroviral Regimens -- Integrase Inhibitors -- Integration -- Integrin Alpha4beta7 -- Interactions Between HIV-2 and Host Restriction Factors -- Kaposi's Sarcoma-associated Herpesvirus (KSHV) or Human Herpesvirus 8 (HHV-8) -- KIR Locus Variation -- Latin America and the Caribbean, specific characteristics of HIV/AIDS epidemic -- Leishmaniasis and HIV -- Long-Acting Nanoformulated Antiretroviral Therapy -- Long-Term Nonprogressors and Elite Controllers -- Lung Cancer -- M. avium Complex and Other Nontuberculous Mycobacteria and HIV -- Macrophages in HIV Immunopathogenesis -- Macrophage-Specific Aspects of HIV-1 Infection -- Male Condoms -- Malignancies in Children with HIV Infection -- Management of AIDS-related Kaposi's Sarcoma -- Mass Media and HIV Prevention -- Maturation Inhibitor -- Medical male circumcision, infant circumcision, Prevention of HIV -- Men who have sex with men (MSM), Epidemiology of HIV/AIDS -- Merkel Cell Carcinoma and Other HIV-Associated Skin Cancers -- Merkel Cell Polyomavirus (MCV) -- MHC Locus Variation -- Microbial Translocation -- Microfinance/Microenterprise Approaches to HIV Prevention -- Microsporidiosis -- Molecular Biology of HIV-2 -- Mother-to-Child Transmission of HIV-1: Role of Receptor Usage and Target Cells -- MTCT HIV-1 Transmission Update: Transmission Routes & Mechanisms -- Mucosal Immunity to HIV-1 -- Mucosal Pathogenesis in SIV Infection -- Multicentric Castleman Disease -- Multilevel Interventions/Structural Approaches to HIV Prevention -- MX2 and HIV-1 Restriction -- Natural History and Clinical Features of HIV-2 Infection -- Natural Killer Cells and Innate Immunity in HIV-2 Infection -- Natural Killer Cells and their Role in Preventing HIV-1 Transmission -- Nef/Env/Vpu/Tetherin -- Network Interventions -- NeuroAIDS in Resource-Poor Settings, Assessment, and Treatment of -- Neuro-AIDS, Immunopathogenesis of -- Neurocognitive Functioning in HIV Substance Users -- Neurocognitive Outcomes in HIV-Infected Children and Adolescents -- Neuroinflammation and HAND: Therapeutic Targeting -- Neuropsychological testing in HIV infected individuals -- Neurotoxic Consequences of Antiretroviral Therapies -- NKT Cells: Bridging Innate and Adaptive Immunity -- Nonhuman Primate Models of HIV Transmission -- Non-injecting drug users, Epidemiology of HIV/AIDS -- Non-Neutralizing Antibody Responses and Protection Against HIV-1 -- Non-Nucleoside Reverse Transcriptase Inhibitors for Treatment of HIV Infection -- Non-Pathogenic SIV Infection of Sooty Mangabeys -- Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs) -- Nuclear Import: HIV-1 Goes NUPs -- Nurse-Delivered Interventions for Adherence -- Origin and Distribution of HIV-1 Subtypes -- Other HPV-Associated Cancers (Oropharyngeal and Penile) -- Overcoming the Transcriptional Block: The HIV-1 Tat Auxiliary Protein -- Overview of HIV CNS Infection -- Overview: Immunopathogenesis -- Programmed Death-1 -- Peer-Based Intervention Approaches -- Phylogeographic Insights into the Origins and Epidemic History of the Human Immunodeficiency Virus Type 2 -- PIMT/TGS1 -- PKR and HIV Replication -- Plasmablastic Lymphoma -- Pneumocystis Jirovecii Infection and HIV -- Positive Health, Dignity, and Prevention (PHDP) -- Post-treatment Controllers -- Preexposure Prophylaxis (PrEP) -- Pregnant Women: Care and Treatment -- Presentation and Pathogenesis of B-Cell Lymphoid Cancers Associated with HIV Infection -- Preventing HIV-1 Transmission Through Vaccine-Induced Immune Responses -- Preventing Mother-to-Child Transmissi.
Format
e-Book
Publication Type
Encyclopedia
Location
Online
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Gene Therapy and Cell Therapy Through the Liver : Current Aspects and Future Prospects

https://libcat.nshealth.ca/en/permalink/provcat40397
Shuji Terai, Takeshi Suda, editors. (1st ed.) --Tokyo: Springer Japan , c2016.
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Location
Online
This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies. Edited by pioneering researchers, this volume presents extensive information to principal investigators, researchers, postdocs, and clinicians for examining the wide varieties of pathological conditions both inside and outside the liver. Providing not only the basic and clinica…
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Other Authors
Terai, Shuji
Suda, Takeshi
Responsibility
Shuji Terai, Takeshi Suda, editors
Edition
1st ed.
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (x, 185 p. : 38 illus., 28 illus. in color)
ISBN
9784431556664
9784431556657 (print ed.)
Subjects (MeSH)
Cell- and Tissue-Based Therapy - methods
Genetic therapy - methods
Liver Diseases - therapy
Regenerative Medicine - instrumentation
Regenerative Medicine - legislation & jurisprudence
Abstract
This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies. Edited by pioneering researchers, this volume presents extensive information to principal investigators, researchers, postdocs, and clinicians for examining the wide varieties of pathological conditions both inside and outside the liver. Providing not only the basic and clinical aspects of therapy, this volume is special in that it focuses on the administrative and regulatory difficulties of actual clinical application and legal regulations in different parts of the globe. By indicating the advantages and limitations of the most promising gene and cell therapies targeting the liver, this book will inspire readers to develop a feasible treatment in the next generation.
Contents
1. Liver-Targeted Gene and Cell Therapies: An Overview -- Part I. Cell Therapy -- 2. Macrophage Therapy for Liver Fibrosis and Regeneration -- 3. Liver Regeneration Therapy Using Autologous Bone Marrow-Derived Cells for Cirrhotic Patients -- 4. Novel Immunotherapy Using Liver Natural Killer Cells for Preventing Recurrence of Hepatocellular Carcinoma in Liver Transplantation -- 5. Cell-Based Immunotherapy for HCC: Our Experiences and Future Directions -- Part II. Gene Therapy -- 6. AAV Vector-Mediated Liver Gene Therapy and Its Implementation for Hemophilia -- 7. Potential Usage of Human Artificial Chromosome for Regenerative Medicine -- 8. Image-Guided Hydrodynamic Gene Delivery to the Liver: Toward Clinical Applications -- Part III. Legal Regulation -- 9. The Way to Clinical Applications of Human Pluripotent Stem Cells -- 10. Regulation for Gene and Cell Therapy Medicinal Products in Europe -- 11. IPSC-Derived Products: Current Regulations -- 12. Critical Path Initiative for Regenerative Medicine in Japan -- 13. Aseptic Manufacturing of Regenerative Medicine Products Using Isolator Technology -- 14. Cell and Vector Production Facility for Gene Therapy and Cell Therapy.
Format
e-Book
Location
Online
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Hypertension : the silent killer

https://libcat.nshealth.ca/en/permalink/provcat34621
Jayasinghe, Jackie. --[Halifax, NS]: Capital Health , 2011.
Call Number
WG 340 J42h 2011 DVD
Access
.
Holdings
Halifax Infirmary: v. 15, 1990 - v. 24, 1994.
Location
Nova Scotia Hospital
Call Number
WG 340 J42h 2011 DVD
Author
Jayasinghe, Jackie
Place of Publication
[Halifax, NS]
Publisher
Capital Health
Date of Publication
2011
Holdings
Halifax Infirmary: v. 15, 1990 - v. 24, 1994.
Physical Description
1 DVD (39 min.)
Series Title
Staying healthy in midlife and beyond
Seniors health series
ISSN
0194-911X
Subjects (MeSH)
Hypertension - popular works
Access
.
Format
DVD
Location
Nova Scotia Hospital
Copies
4
Loan Period
3 weeks
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Immunology of aging

https://libcat.nshealth.ca/en/permalink/provcat33805
Ahmad Massoud, Nima Rezaei, editors. --Heidelberg: Springer , c2014.
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Location
Online
Available Online
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Other Authors
Massoud, Ahmad
Rezaei, Nima
Responsibility
Ahmad Massoud, Nima Rezaei, editors
Place of Publication
Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xix, 406 pages)
ISBN
9783642394959 (electronic bk.)
9783642394942
Subjects (MeSH)
Aging - immunology
Immune System Phenomena - physiology
Subjects (LCSH)
Immunology
Geriatrics
Emerging infectious diseases
Contents
An introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress and aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.
Format
e-Book
Location
Online
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Immunotherapy of Cancer : An Innovative Treatment Comes of Age

https://libcat.nshealth.ca/en/permalink/provcat40389
Yoshiyuki Yamaguchi, editor. (1st ed.) --Tokyo: Springer Japan , c2016.
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Location
Online
This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy ha…
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Other Authors
Yamaguchi, Yoshiyuki
Responsibility
Yoshiyuki Yamaguchi, editor
Edition
1st ed.
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (ix, 358 p. : 46 illus., 8 illus. in color)
ISBN
9784431550310
9784431550303 (print ed.)
Subjects (MeSH)
Adjuvants, Immunologic - therapeutic use
Cancer Vaccines
Immunotherapy
Neoplasms - immunology
Neoplasms - therapy
Abstract
This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.
Contents
Part I. Overview, History, Classification -- 1. Overview of Current Cancer Immunotherapy -- Part II. BRMs and Crude Agents -- 2. Bacterial Preparations -- 3. Polysaccharides -- 4. BCG -- Part III. Cytokines -- 5. ø-T Cells -- 6. NKT Cell-Based Immunotherapy -- 7. Natural Killer Cells -- 8. þ T Cell-Based Cancer Immunotherapy -- 9. Genetically engineered T cells -- Part IV. Vaccine Therapy -- 10. Peptide Vaccine -- 11. Personalized Peptide Vaccine -- 12. WT1 Peptide Vaccine for the Treatment of Malignancies -- 13. Protein vaccine -- 14. Dendritic Cell-Based Vaccine for Cancer -- Part V. Immunoadjuvants -- 15. CpG Motif -- 16. Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy -- 17. Novel Adjuvants -- Part VI. Immunocheckpoints -- 18. Anti-CTLA-4 Ab -- 19. Anti-PD-1, PD-L1 Ab -- 20. Novel Targets of Immune Inhibitory and Stimulatory Co-signals -- Part VII. Regulation of Immunosuppression -- 21. Regulatory T Cells -- 22. MDSC: Myeloid-Derived Suppressor Cells -- Part VIII. Immune-Related Response Criteria and Guidance for Clinical Trials -- 23. Immune-Related Response Criteria and Guidance for Clinical Trials -- Part IX. Personalized Immunotherapy -- 24. Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy.
Format
e-Book
Location
Online
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In the blink of an eye : the deadly story of epidemic meningitis

https://libcat.nshealth.ca/en/permalink/provcat32404
Andrew W. Artenstein, author. --New York, NY: Springer , c2013.
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Location
Online
Describing more than two centuries of epidemic meningitis, In the Blink of an Eye introduces a deadly and frightening bacterial infection of the brain, one that afflicts healthy children and young adults in dramatic fashion, often changing or taking lives in just hours or days. Meningococcal meningitis is the culprit, causing sporadic cases as well as explosive, unpredictable outbreaks of disease throughout the world, leading to the deaths of dozens to hundreds of thousands every year. Beginnin…
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Author
Artenstein, Andrew W
Responsibility
Andrew W. Artenstein, author
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (ix, 138 p. : 22 ill., 5 ill. in color)
ISBN
9781461448457
Subjects (MeSH)
Meningitis, Meningococcal - history
Vaccines - history
Subjects (LCSH)
Infectious diseases
Abstract
Describing more than two centuries of epidemic meningitis, In the Blink of an Eye introduces a deadly and frightening bacterial infection of the brain, one that afflicts healthy children and young adults in dramatic fashion, often changing or taking lives in just hours or days. Meningococcal meningitis is the culprit, causing sporadic cases as well as explosive, unpredictable outbreaks of disease throughout the world, leading to the deaths of dozens to hundreds of thousands every year. Beginning with the case of a healthy teenage boy who rapidly succumbs to the disease, the book traces meningitis through its various social contexts. From the acceptance of the germ theory of disease and the birth of the sister sciences of microbiology and immunology in the nineteenth century to the modern molecular era, the story traverses more than 200 years of medical history. It leads us through the early descriptions of the disease, its impact on military forces, large outbreaks of meningitis in Africa and elsewhere, and the evolution of approaches to its treatment, control, and prevention. In so doing, we witness the development of modern medical research and education, the discovery of antibiotics, the rapid emergence of drug-resistant bacteria, the invention of a novel class of vaccines, and learn the inner workings of disease processes and the human immune system. The story of meningococcal meningitis, winding through the evolution of infectious diseases, the great European capitals of nineteenth century science, the Rockefeller Institute, the dye industry, Nazi Germany, military medicine, the Vietnam era, and prospects for an end to epidemic disease, parallels the rise of modern medical science.
Contents
Origins -- The Art and Science of Germs -- A Singular Disease -- A Very Mortal Disease -- Early Approaches at Therapy -- Antibiotics and Survival of the Fittest -- A Brief History of Vaccines -- That Soulble Specific Substance -- Towards a Vaccine -- Success for Half -- The Future of a Killer.
Format
e-Book
Location
Online
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Malaria : genetic and evolutionary aspects

https://libcat.nshealth.ca/en/permalink/provcat40965
[edited by] Krishna R. Dronamraju and Paolo Arese. --New York, NY: Springer , c2006.
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Location
Online
This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There wer…
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Author
Dronamraju, Krishna R.
Other Authors
Arese, Paolo
Responsibility
[edited by] Krishna R. Dronamraju and Paolo Arese
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2006
Physical Description
1 online resource (xi, 190 p. : ill.)
Series
Emerging Infectious Diseases of the 21st Century
Series Vol.
4
ISBN
9780387282954
9780387282947 (print ed.)
Subjects (MeSH)
Evolution, Molecular
Malaria - genetics
Malaria - prevention & control
Abstract
This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane’s malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration.
Contents
Introduction -- J.B.S. Haldane (1892-1964) -- Removal of Early Parasite Forms from Circulation as a Mechansism of Resistance Against Malaria in Widespread Red Blood Cells Mutations -- Clinical, Epidemiological and Genetic Investigations on Thalassemia and Malaria in Italy -- Resistance to Antimalarial Drugs: Parasite and Host Genetic Factors -- Evolutionary Origins on Human Malaria Parasites -- The Rate of Mutation of Human Genes -- Disease and Evolution.
Format
e-Book
Location
Online
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Oncoimmunology : A Practical Guide for Cancer Immunotherapy

https://libcat.nshealth.ca/en/permalink/provcat42777
Laurence Zitvogel, Guido Kroemer, editors. --Cham: Springer , c2018.
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Location
Online
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare …
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Other Authors
Zitvogel, Laurence
Kroemer, Guido
Responsibility
Laurence Zitvogel, Guido Kroemer, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (x, 724 p.) : 133 illus., 131 illus. in color
ISBN
9783319624310
9783319624303 (print ed.)
9783319624327 (print ed.)
9783319873107 (print ed.)
Subjects (MeSH)
Cancer Vaccines
Immunotherapy
Neoplasms - immunology
Neoplasms - therapy
Specialty
Medical Oncology
Vaccinology
Abstract
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Contents
1. Principles of Oncoimmunology -- Part I. Fundamentals in I-O -- 2. The Human Tumor Microenvironment -- 3. CD8+ T Cells in Immunotherapy, Radiotherapy, and Chemotherapy -- 4. Mutant Epitopes in Cancer -- 5. The Secrets of T Cell Polarization -- 6. Regulatory T Cells: Their Role, Mechanism of Action, and Impact on Cancer -- 7. Purinergic Receptors: Novel Targets for Cancer Immunotherapy -- 8. Plasmacytoid DC/Regulatory T Cell Interactions at the Center of an Immunosuppressive Network in Breast and Ovarian Tumors -- 9. Cancer Immunosurveillance by Natural Killer Cells and Other Innate Lymphoid Cells -- 10. Biology of Myeloid-Derived Suppressor Cells -- 11. Effect of Pharmaceutical Compounds on Myeloid-Derived Suppressor Cells -- 12. Immunogenic Stress and Death of Cancer Cells in Natural and Therapy-Induced Immunosurveillance -- 13. Genetics and Immunology: Tumor-Specific Genetic Alterations as a Target for Immune Modulating Therapies -- Part II. Breakthrough Status -- 14. Peptide-Based Therapeutic Cancer Vaccines -- 15. Cancer Vaccines for HPV Malignancies -- 16. NK Cell-Based Therapies -- 17. IDO/TDO Inhibition in Cancer -- Part III FDA-EMA Approval of I-O -- 18. Tumor-Targeted Antibodies -- 19. PD1 Checkpoint Blockade in Melanoma: From Monotherapy to Combination Therapies -- 20. Immune Checkpoint Inhibition in Lung Cancer -- 21. PD-1 Blockade in Renal Cell Carcinoma -- 22. BCG and Anti-PDL-1 Ab in Bladder Cancers -- 23. PD-L1 and Other Immunological Diagnosis Tools -- 24. Oncolytic Viruses: T-VEC and Others -- Part IV. Developing Fields -- 25. Innate Immune Receptors in the Regulation of Tumor Immunity -- 26. Co-stimulation Agonists via CD137, OX40, GITR, and CD27 for Immunotherapy of Cancer -- 27. The Impact of the Intestinal Microbiota in Therapeutic Responses Against Cancer -- 28. Local Immunotherapies of Cancer -- 29. Strategies to Reduce Intratumoral Regulatory T Cells -- 30. Synergy Between Radiotherapy and Immunotherapy -- 31. Predictors of Response to Immune Checkpoint Blockade -- Part V. Changes in Clinical Practice -- 32. Immune Therapies in Phase 1 Trials -- 33. Side Effects of Cancer Immunotherapy with Checkpoint Inhibitors -- 34. Melanoma: Immunotherapy in Advanced Melanoma and in the Adjuvant Setting -- 35. Immunotherapy for Prostate Cancer: An Evolving Landscape -- 36. Challenges of Oncoimmunology for Ovarian and Breast Cancers -- 37. Challenges in Colorectal Cancer: From Vaccines to Macrophage Repolarization -- 38. Current Status of Immuno-Oncology in Hematologic Cancers -- 39. Immunotherapy of Gliomas -- 40. Assessing T Cell Receptor Affinity and Avidity Against Tumor Antigens -- 41. Immune Monitoring of Blood and Tumor Microenvironment -- 42. Toward Engineered Cells as Transformational and Broadly Available Medicines for the Treatment of Cancer -- Part VI. Concluding Remarks -- 43. Concluding Remarks.
Format
e-Book
Location
Online
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Social Neuroscience and Public Health : Foundations for the Science of Chronic Disease Prevention

https://libcat.nshealth.ca/en/permalink/provcat40731
Peter A. Hall, editor. --New York, NY: Springer , c2013.
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Location
Online
Traditionally, neuroscience and public health have been considered strange bedfellows. Now a new collection of studies shows the two fields as logical collaborators with major potential for the evolution of both fields. Social Neuroscience and Public Health assembles current theoretical viewpoints, research findings in familiar and emerging areas, and updates on assessment methods to give readers a unique in-depth guide to the social brain and its central role in health promotion. This stimulat…
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Other Authors
Hall, Peter A (Peter Anthony) 1972-
Responsibility
Peter A. Hall, editor
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xvi, 318 p. : ill.)
ISBN
9781461468523
9781461468516 (print ed.)
Subjects (MeSH)
Chronic Disease - prevention & control
Health Behavior
Neurosciences - methods
Public Health
Social Behavior
Abstract
Traditionally, neuroscience and public health have been considered strange bedfellows. Now a new collection of studies shows the two fields as logical collaborators with major potential for the evolution of both fields. Social Neuroscience and Public Health assembles current theoretical viewpoints, research findings in familiar and emerging areas, and updates on assessment methods to give readers a unique in-depth guide to the social brain and its central role in health promotion. This stimulating reference spans the intersection of two disciplines, offering new insights into the mechanics of risks, rewards, and willpower, revisiting the developmental effects of adversity and the impact of exercise on brain health, and applying epidemiology to cognitive science. Accessibly written for researchers and professionals within and outside both fields, the chapters include bullet-point and policy implication features for ease of retention. The book's innovative ideas lend themselves to a variety of applications, from fine-tuning disease prevention strategies to deeper understanding of addictions. Included in the coverage: Latest theoretical perspectives on health behavior (e.g., picoeconomics, MCII, and temporal self-regulation theory) Updates on health communications and their effects on the brain. New research on cognitive resources and health behavior execution. Leading-edge studies on the brain, the social world, and stress. Findings from the forefront of exercise neuroscience. A concise introduction to neuroscience methods for the non-technical reader. A rich resource pointing to a promising future in research and prevention efforts, Social Neuroscience and Public Health benefits professionals and researchers in public health, medicine, cognitive neuroscience, health psychology, epidemiology, sociology and affiliated fields. "This bridge-builder of a book comes exactly at the right time. With the field of public health rapidly expanding, public health professionals, neuroscientists, social psychologists, and policymakers alike will profit from this immensely integrative achievement. Social Neuroscience and Public Health connects two fast-developing fields that can learn and profit immensely from each other." -- Wilhelm Hofmann, PhD, University of Chicago, Booth School of Business. "In this book you will find a number of intriguing possibilities for changing behaviour that arise out of a scientific base hitherto little known beyond the field. Bringing this together has immense potential not just for strengthening public health but also for strengthening behavioral and neuro-sciences." -- Theresa Marteau, PhD, Institute of Public Health, Unviersity of Cambridge.
Contents
Part I. Theoretical Perspectives -- 1. Picoeconomics in Neural and Evolutionary Contexts -- 2. Neurophysiological Correlates of the Self-Regulation of Goal Pursuit -- 3. Temporal Self-regulation Theory: Integrating Biological, Psychological and Ecological Determinants of Health Behavior Performance -- Part II. Health Communication -- 4. Health Communications: Predicting Behavior Change From the Brain -- 5. Neurobiological Bases of Self-reference and Deliberate Processing in Tailored Health Communication -- Part III. Health Behaviors -- 6. Neurocognition and Medication Adherence in HIV Infected Adults -- 7. Alcohol Consumption and Self-Regulation -- 8. The Strength Model of Self-Control: Recent Advances and Implications for Public Health -- 9. Incentive-Based Interventions: Historical Context and New Directions -- Part IV. Social Connections, Socioeconomic Status and Stress -- 10. Social Relationships and Public Health -- 11. Brain Functions Modulating Redistribution of Natural Killer Cells Accompanying Cognitive Appraisal of Acute Stress -- 12. Alzheimer's Dementia and Lifestyle: Towards a Primary Prevention -- 13. Social Determinants of Self-regulation Development -- Part V. Exercise Neuroscience -- 14. Physical Activity, Cardiorespiratory Fitness and Cognition across the Lifespan -- 15. Brain Glycogen Decrease and Supercompensation with Prolonged Exhaustive Exercise -- 16. Resistance Training and Cognitive and Cortical Plasticity in Older Adults -- Part VI. Methods Primer -- 17. Brain Imaging: A Primer -- 18. Survival Analysis in Social Neuroscience and Public Health: A Research Exemplar from the Field of Cognitive Epidemiology -- 19. Neurobiological Facets of Food Craving and Consumption: Evidence from Neuropsychological and Transcranial Magnetic Stimulation (TMS) Studies.
Format
e-Book
Location
Online
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Stroke Prevention in Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat40641
Daryll M. Baker. --London: Springer , c2008.
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Location
Online
Comprised of short chapters written in a succinct and bulleted style, with clear diagrams and figures to illustrate where appropriate, Stroke Prevention in Clinical Practice is ideal for the busy doctor looking for a comprehensive pocket-sized guide to the everyday management of transient ischaemic attacks (TIAs) and strokes. Strokes are the major cause of disability in the UK, and also the third biggest killer, but awareness and active intervention can prevent the dangers of strokes especially…
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Author
Baker, Daryll M
Responsibility
Daryll M. Baker
Place of Publication
London
Publisher
Springer
Date of Publication
c2008
Physical Description
1 online resource (viii, 131 p. : 30 illus.)
ISBN
9781846287282
9781852339647 (print ed.)
Subjects (MeSH)
Myocardial Ischemia - prevention & control
Risk Factors
Stroke - diagnosis
Stroke - prevention & control
Stroke - therapy
Abstract
Comprised of short chapters written in a succinct and bulleted style, with clear diagrams and figures to illustrate where appropriate, Stroke Prevention in Clinical Practice is ideal for the busy doctor looking for a comprehensive pocket-sized guide to the everyday management of transient ischaemic attacks (TIAs) and strokes. Strokes are the major cause of disability in the UK, and also the third biggest killer, but awareness and active intervention can prevent the dangers of strokes especially in high-risk groups. By starting with an explanation of TIAs, which so often preceed strokes, this work aims to make more physicians aware of the treatment regimens necessary to manage TIAs. It is vital to be aware of the early signs of TIAs, and be able to recognise them as soon as possible since a considerable amount of stroke prevention treatment stems from knowing the warning signs and taking action. This book discusses how to accurately diagnose the leading causes of strokes, and offers comprehensive treatment advice to avoid future recurrences, with all chapters written by leading experts in the field.
Contents
I. Introduction -- The Significance Of Stroke -- Identifying Patients at Risk of Ischemic Stroke -- Investigating Patients at Risk of Stroke -- II. Reducing the Risk of Stroke by Reducing Embolic Events -- Antiplatelet Therapy -- Reducing Cardioembolic Events -- Reducing Cervical Vessel Embolic Events -- III. Reducing the Risk of Stroke by Modifying Atherosclerotic Risk Factors -- Managing Hypertension -- Managing Diabetes -- Managing Hyperlipidemia -- Reducing the Risk of Stroke by Modifying Life Style -- Identifying Other Atherosclerotic Diseases -- Managing Lacunar Infarcts -- Part IV. Reducing the Risk of Stroke by Reducing Procoagulant (Thrombotic) Risk Factors -- Managing Procoagulant Thrombotic States -- V. Reducing the Risk of Stroke from Other Causes -- Managing Central Nervous System Vasculitis -- Managing Stroke in Human Immunodeficiency Virus-Infected Patients -- Thyroid Diseases and Stroke -- VI. Prevention of Other Cardiovascular Events in Cerebrovascular Patients -- Management of Silent Myocardial Ischemia in Stroke Patients.
Format
e-Book
Publication Type
Handbook
Location
Online
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T-Cell and NK-Cell Lymphomas : From Biology to Novel Therapies

https://libcat.nshealth.ca/en/permalink/provcat44039
Christiane Querfeld, Jasmine Zain, Steven T. Rosen, editors. --Cham: Springer , 2019.
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Location
Online
In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient…
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Other Authors
Querfeld, Christiane
Zain, Jasmine
Rosen, Steven T.
Responsibility
Christiane Querfeld, Jasmine Zain, Steven T. Rosen, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 287 p.) : 40 illus., 37 illus. in color
Series
Cancer Treatment and Research
Series Vol.
176
Series Title
Cancer treatment and research
ISBN
9783319997162
9783319997155 (Print ed.)
9783319997179 (Print ed.)
ISSN
0927-3042
Subjects (MeSH)
Killer Cells, Natural - pathology
Lymphoma - physiopathology
Lymphoma - therapy
T-Lymphocytes - pathology
Specialty
Medical Oncology
Abstract
In this book, a group of internationally distinguished lymphoma experts provide a comprehensive review of the most important advances in the biology, diagnosis, and therapy of T cell and NK cell malignancies. In particular, it demonstrates in detail how advances in our understanding of the tumor microenvironment and molecular biology have helped to elucidate the pathogenesis of these lymphomas, improve diagnostic and prognostic accuracy, and develop novel therapies that promise improved patient outcomes. Individual chapters are devoted to particular tumor types and subtypes, and all aspects of transplantation for patients with T cell and NK cell lymphomas are discussed. As such, the book offers a valuable resource for hematologists, oncologists, hematopathologists, and all those seeking an up-to-date overview of how new, targeted therapies are delivering better disease control and improved quality of life.
Contents
1. Epidemiology and pathology of T- and NK-cell lymphomas -- 2. Molecular and genomic landscape of peripheral T-cell lymphoma -- 3. Tumor microenvironment in T-cell lymphomas -- 4. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) -- 5. Angioimmunoblastic T-cell lymphoma -- 6. Anaplastic large cell lymphoma: contemporary concepts and optimal management -- 7. Adult T-cell leukemia-lymphoma -- 8. NK-cell lymphomas -- 9. Hepatosplenic T-cell lymphomas -- 10. Rare T-cell subtypes -- 11. Primary cutaneous T-cell lymphomas: mycosis fungoides and Sezary syndrome -- 12. CD30-positive lymphoproliferative disorders -- 13. Transplantation.
Format
e-Book
Location
Online
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Th 17 Cells : Role in Inflammation and Autoimmune Disease

https://libcat.nshealth.ca/en/permalink/provcat40954
Valérie Quesniaux, Bernhard Ryffel, Franco Di Padova, editors. --Basel: Birkhäuser Verlag , c2009.
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Location
Online
With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22; the…
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Other Authors
Quesniaux, Valérie
Ryffel, Bernhard
Padova, Franco Di
Responsibility
Valérie Quesniaux, Bernhard Ryffel, Franco Di Padova, editors
Place of Publication
Basel
Publisher
Birkhäuser Verlag
Date of Publication
c2009
Physical Description
1 online resource (xii, 244 p. : 20 illus.)
Series Title
Progress in inflammation research
ISBN
9783764386818
9783764386801 (print ed.)
Subjects (MeSH)
Antibodies, Neutralizing
Autoimmune Diseases - etiology
Inflammation - etiology
Th17 Cells - immunology
Abstract
With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of the Th17 cell subset and its prevalent role in many inflammatory and autoimmune diseases. The mechanism by which this T cell subset is generated and maintained shows specific differences between mice and man which are reviewed. One characteristic of Th17 cells is to secrete specific and unique cytokines such as IL-17A, IL-17F and IL-22; their functions are described in detail. These cytokines have acquired a prevalent role in many pathological conditions in animal models and in humans. Targeting these cytokines as well as the generation of Th17 cells may open new ways to treat many autoimmune diseases. The role of Th17 in infectious conditions is also addressed.
Contents
Discovery and IL-17 family -- IL-22 and IL-17: Common and different properties -- Other sources of IL-17: Invariant natural killer T cells -- Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues -- Retinoic acid in mucosal immune-regulation -- IL-25, another promoter of allergy -- Experimental models of disease -- Critical role of IL-17 in experimental arthritis -- Dual role of IL-17 in allergic asthma -- Contribution of IL-17 to the pulmonary inflammatory response -- The role of IL-17 in experimental autoimmune myocarditis -- Th17 cells in organ transplantation -- Role of IL-23/IL-17 in infection and tumor control -- Is IL-17 required to control tuberculosis? -- IL-17 and mucosal host defense -- IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation -- IL-17 in clinical autoimmune disease -- IL-17 and Th17 cells in rheumatoid arthritis -- Targeting Th17 cells in CNS immune pathology -- IL-17 cytokines in asthma -- IL-17/23, potential targets for Crohn's disease -- Novel tools and therapeutic avenues -- IL-17A and Th17 cells as therapeutic targets for autoimmune diseases.
Format
e-Book
Location
Online
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Uterine Endometrial Function

https://libcat.nshealth.ca/en/permalink/provcat40419
Hideharu Kanzaki, editor. --Tokyo: Springer Japan , c2016.
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Location
Online
This book focuses on uterine endometrial function and receptivity from multiple perspectives. The chapters cover a variety of topics including the role of estrogen and progesterone, animal models, parameters for assessing endometrial receptivity, the mechanism of angiogenesis, epigenetic regulation, and stem/progenitor cells. Despite nearly 35 years of experience with in vitro fertilization, the rate of successful implantations remains low. Abnormal endometrial receptivity has been proposed as …
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Other Authors
Kanzaki, Hideharu
Responsibility
Hideharu Kanzaki, editor
Place of Publication
Tokyo
Publisher
Springer Japan
Date of Publication
c2016
Physical Description
1 online resource (vii, 155 p. : 31 illus., 24 illus. in color)
ISBN
9784431559726
9784431559702 (print ed.)
Subjects (MeSH)
Endometrium - physiology
Zygote - physiology
Abstract
This book focuses on uterine endometrial function and receptivity from multiple perspectives. The chapters cover a variety of topics including the role of estrogen and progesterone, animal models, parameters for assessing endometrial receptivity, the mechanism of angiogenesis, epigenetic regulation, and stem/progenitor cells. Despite nearly 35 years of experience with in vitro fertilization, the rate of successful implantations remains low. Abnormal endometrial receptivity has been proposed as one of the factors contributing to reduced reproductive potential in women, but our understanding of it is limited. Endometrial receptivity results from an orchestrated interplay between the embryo and the maternal endometrium, and the receptive status, known as the window of implantation, is reached only briefly in the mid-luteal phase. This book provides a comprehensive overview of the latest advances in endometrial function and paves the way for innovative treatments and drug development for infertility. This work will appeal to a wide readership, from researchers on endometrial function and assisted reproductive technology (ART) to clinicians and technicians in the field of gynecology.
Contents
1. ERa signal pathways regulating Bcl-2 transcription in human endometrial glands -- 2. Uterine receptivity in mouse embryo implantation -- 3. Assessing receptivity of the human endometrium to improve outcomes of fertility treatment -- 4. Role of circulating blood cells in maternal tissue remodeling and embryo-maternal cross talk -- 5. Functional role of uterine natural killer cells -- 6. Regulation of angiogenesis in the human endometrium -- 7. Oxidative stress and its implications in endometrial function -- 8. Decidualization and Epigenetic Regulation -- 9. Stem/progenitor cells in the human endometrium.
Format
e-Book
Location
Online
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