Molecular diagnostics and treatment of pancreatic cancer : systems and network biology approaches
https://libcat.nshealth.ca/en/permalink/provcat33143
edited by Asfar S. Azmi.
--Amsterdam, Netherlands:
Elsevier/AP
, 2014.
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Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expres…
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- Other Authors
- Azmi, Asfar S
- Responsibility
- edited by Asfar S. Azmi
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Elsevier/AP
- Date of Publication
- 2014
- Physical Description
- 1 online resource (xx, 446 p.)
- ISBN
- 9781306642347 (electronic bk)
- Subjects (MeSH)
- Pancreatic Neoplasms - diagnosis
- Molecular Diagnostic Techniques
- Pancreatic Neoplasms - genetics
- Pancreatic Neoplasms - therapy
- Signal transduction
- Tumor Markers, Biological
- Subjects (LCSH)
- Pancreas - Cancer - Molecular diagnosis
- Pancreas - Cancer - Treatment
- Pancreatic Neoplasms - diagnosis
- Molecular Diagnostic Techniques
- Pancreatic Neoplasms - genetics
- Pancreatic Neoplasms - therapy
- Signal Transduction
- Tumor Markers, Biological
- Abstract
- Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets.
- Contents
- Front Cover; MOLECULAR DIAGNOSTICS AND TREATMENT OF PANCREATIC CANCER: SYSTEMS AND NETWORK BIOLOGY APPROACHES; Copyright; DEDICATION; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; Section I -- Current Trends and Advances in Pancreatic Cancer; Chapter 1 -- Epidemiology, Treatment, and Outcome of Pancreatic Cancer; INTRODUCTION; EPIDEMIOLOGY AND ETIOLOGY OF PANCREATIC CANCER; TYPES OF PANCREATIC CANCER; CLINICAL PRESENTATION OF PANCREATIC CANCER; DIAGNOSIS OF PANCREATIC CANCER; TREATMENT OF PANCREATIC CANCER; POTENTIALLY CURATIVE SURGICAL TREATMENT; ADJUVANT AND NEOADJUVANT TREATMENT -- PROGNOSIS OF PANCREATIC CANCEROUTLOOK; REFERENCES; Chapter 2 -- Advances in Primary Cell Culture of Pancreatic Cancer; INTRODUCTION; CELL CULTURE OF PDAC; ISOLATION AND ESTABLISHMENT PROCEDURE; CHARACTERIZATION OF CELL CULTURES; MORPHOLOGY; GENOTYPING; PHENOTYPING; SECOND LEVEL OF BIOLOGICAL MODELS; THREE-DIMENSIONAL CELL CULTURES; IN VIVO MODELS; APPLICATIONS; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 3 -- Multimodal Therapies for Pancreatic Cancer; INTRODUCTION; CONCLUSION; REFERENCES; Chapter 4 -- The Role of Notch Signaling Pathway in the Progression of Pancreatic Cancer; INTRODUCTION -- NOTCH SIGNALING PATHWAYTHE ROLE OF NOTCH IN PC; NOTCH INHIBITION IS A NOVEL STRATEGY FOR PC TREATMENT; UNDERSTANDING NOTCH SIGNALING THROUGH SYSTEMS BIOLOGY; CONCLUSION; REFERENCES; Section II -- Gene Expression Profiling and Bioinformatics Analysis in Pancreatic Cancer; Chapter 5 -- Bioinformatics Analysis of Pancreas Cancer Genome in High-Throughput Genomic Technologies; INTRODUCTION; HETEROGENEITY AND QUALITY OF SAMPLES FOR HIGH-THROUGHPUT GENOMIC TECHNOLOGIES; MICROARRAYS; NEXT-GENERATION SEQUENCING; DATABASES AND RESOURCES; CONCLUSION AND FUTURE PERSPECTIVES; ACKNOWLEDGEMENTS; REFERENCES -- Chapter 6 -- Statistical Analysis of High-Dimensional Data for Pancreatic CancerINTRODUCTION; LASSO PENALIZED COX REGRESSION; DOUBLY REGULARIZED COX REGRESSION; PANCREATIC CANCER SURVIVAL ANALYSIS; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 -- Gene Expression Profiling in Pancreatic Cancer; INTRODUCTION; SUMMARY; REFERENCES; Chapter 8 -- Genetic Susceptibility and Risk of Pancreatic Cancer; INTRODUCTION; FAMILIAL RISK OF PANCREATIC CANCER; RARE, HIGH-RISK PANCREATIC CANCER SUSCEPTIBILITY GENES AND MULTICANCER SYNDROMES; COMMON, LOW-RISK PANCREATIC CANCER SUSCEPTIBILITY LOCI -- COMMON PANCREATIC CANCER RISK LOCI IN NON-EUROPEAN POPULATIONSPATHWAY ANALYSES OF PANCREATIC CANCER GWAS DATA SETS; FUTURE GWAS AND GENE MAPPING APPROACHES; WEBSITES; REFERENCES; Section III -- Pancreatic Cancer Proteomics; Chapter 9 -- Proteomics in Pancreatic Cancer Translational Research; INTRODUCTION; OVERVIEW OF PROTEOMICS TECHNOLOGIES; PROTEOMICS STUDY OF PANCREATIC TISSUE; BLOOD BIOMARKER DISCOVERY; ANALYSIS OF PANCREATIC JUICE AND CYST FLUID; FUNCTIONAL AND HYPOTHESIS-DRIVEN PROTEOMIC STUDIES; POST-TRANSLATIONAL MODIFICATIONS; SUMMARY; ACKNOWLEDGMENT; REFERENCES -- Chapter 10 -- Proteomic Differences and Linkages between Chemoresistance and Metastasis of Pancreatic Cancer Using Knowledge-Based Pathway Analysis.
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