Controversies in Treating Diabetes : Clinical and Research Aspects
https://libcat.nshealth.ca/en/permalink/provcat30306
edited by Derek LeRoith, Aaron I. Vinik.
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- LeRoith, Derek
- Other Authors
- Vinik, Aaron I
- Responsibility
- edited by Derek LeRoith, Aaron I. Vinik
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- Series Title
- Contemporary endocrinology (Totowa, N.J.)
- ISBN
- 9781597455725
- Subjects (MeSH)
- Diabetes Mellitus - therapy
- Subjects (LCSH)
- Diabetes
- Format
- e-Book
- Location
- Online
Prevention of Type 2 Diabetes : From Science to Therapy
https://libcat.nshealth.ca/en/permalink/provcat30970
Derek LeRoith, editor.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
There is a world-wide epidemic on obesity. This epidemic is driving the immense proportions of Type 2 diabetes across the globe. While there are numerous therapies for treating Type 2 diabetes, the most effective therapy is prevention. Prevention of Type 2 diabetes can be achieved properly by simultaneous prevention of obesity. Prediabetes, or metabolic syndrome, is the period between simple obesity and diabetes, and this critical period needs to be identified in a more consistent and systemati…
- Available Online
- View e-Book
- Author
- LeRoith, Derek
- Responsibility
- Derek LeRoith, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xii, 288 p. : 51 ill., 37 ill. in color)
- ISBN
- 9781461433149
- Subjects (MeSH)
- Diabetes Complications - prevention & control
- Diabetes Mellitus, Type 2 - physiopathology
- Diabetes Mellitus, Type 2 - prevention & control
- Prediabetic State - prevention & control
- Primary Prevention - methods
- Subjects (LCSH)
- Diabetes
- Endocrinology
- Abstract
- There is a world-wide epidemic on obesity. This epidemic is driving the immense proportions of Type 2 diabetes across the globe. While there are numerous therapies for treating Type 2 diabetes, the most effective therapy is prevention. Prevention of Type 2 diabetes can be achieved properly by simultaneous prevention of obesity. Prediabetes, or metabolic syndrome, is the period between simple obesity and diabetes, and this critical period needs to be identified in a more consistent and systematic manner by clinicians worldwide. Clinical trials have indicated that diabetes prevention can be achieved by lifestyle changes and also by certain medications, though none are yet approved for use in prevention. On the other hand, there are funding agencies such as the NIH, CDC, and State Institutions that are interested in studying the prevention paradigms in different communities and ethnic minorities who are most prone to this epidemic. For these reasons, this title by renowned physician-scientist Derek LeRoith is both timely and vitally important for academic physicians, practitioners, allied health care providers, analysts, community activists, and all others interested in this increasing epidemic. This book provides a unique and comprehensive synthesis of the prevention and early diagnosis of Type 2 Diabetes, focusing on identifying risk factors and then moving into topics that address how to prevent their progression to full-blown diabetes. The difficult task of changing patients' behavior is given special emphasis. The chapters in this practical volume are written by a wide range of international experts, refelecting the editor's distinguished, internationally renowned career. The volume is organized in eight sections: an introduction to the overall issue of prevention, definitions of values based on ADA guidelines, pathophysiology, discussion of a range of interventional trials regarding prevention, and an overview of state-of-the-art clinical management approaches. Comprehensive and timely, Prevention of Type 2 Diabetes: From Science to Therapy is an essential reference for those treating and researching Type 2 Diabetes
- Contents
- 01. Prevention of Type 2 Diabetes: From Science to Therapies -- 02. Pathophysiology: Loss of [beta]-cell function -- 03. Pathophysiology of Insulin Resistance: Implications for Prevention -- 04. Epidemiology Including Youth through Adulthood and Socioeconomic Impact -- 05. Prediabetes Genes in Pima and Amish -- 06. Predicting Diabetes -- 07. Screening for Prediabetes and Diabetes -- 08. Neuropathy in pre-Diabetes and the Metabolic Syndrome -- 09. Interventional Trials to Prevent Diabetes: Diabetes Prevention Program -- 10. Decreasing Postprandial Plasma Glucose Using an [alpha]-Glucosidase Inhibitor in Subjects with IGT for the Prevention of Type 2 Diabetes Mellitus: The STOP-NIDDM Trial -- 11. Da Qing, Finnish DPP, Tripod and Dream: Lifestyle and Thiazolidinediones in the Prevention of Diabetes -- 12. Community Approaches to Diabetes Prevention -- 13.Think Locally, Act Locally, Extend Globally: Diabetes Prevention Through Partnerships with Local Communities -- 14. Global Challenge in Diabetes Prevention from Practice to Public Health.
- Format
- e-Book
- Location
- Online
Insulin-like Growth Factors and Cancer : From Basic Biology to Therapeutics
https://libcat.nshealth.ca/en/permalink/provcat30917
Derek LeRoith, editor.
--New York, NY:
Humana Press
, c2012.
- Available Online
- View e-Book
- Location
- Online
The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses …
- Available Online
- View e-Book
- Other Authors
- LeRoith, Derek
- Responsibility
- Derek LeRoith, editor
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xii, 284 p. : 22 ill., 17 ill. in color)
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781461405986
- Subjects (LCSH)
- Oncology
- Endocrinology
- Abstract
- The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials.
- Contents
- Epidemiology of IGF-1 and Cancer -- Aging and Cancer: The IGF-1 Connection -- Obesity, Type 2 Diabetes and Cancer -- IGF System and Breast Cancer -- The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression -- IGF-1 Cellular Action and its Relationship to Cancer: Evidence from in Vitro and in Vivo Studies -- Insulin-like Growth Factor Signaling in Pediatric Sarcomas -- Cancer Genes, Tumor Suppressors, and Regulation of IGF-1R Expression in Cancer -- Mouse Models of IGF-1R and Cancer -- Targeting the Insulin-Like Growth Factor-1 Receptor in Cancer Therapy -- Targeting Insulin-like Growth Factor 1 (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer -- Calories and Cancer: The Role of Insulin-like Growth Factor-1 -- Cancer Cell Metabolism -- Overlaps Between the Insulin and IGF-1 Receptor and Cancer -- Index.
- Format
- e-Book
- Location
- Online
Principles of Endocrinology and Hormone Action
https://libcat.nshealth.ca/en/permalink/provcat42946
Antonino Belfiore, Derek LeRoith, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, an…
- Available Online
- View e-Book
- Other Authors
- Belfiore, Antonino
- LeRoith, Derek
- Responsibility
- Antonino Belfiore, Derek LeRoith, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xix, 796 p.) : 125 illus., 92 illus. in color
- Series Title
- Springer reference
- Endocrinology
- ISBN
- 9783319446752
- 9783319446745 (print ed.)
- ISSN
- 2510-1927
- Subjects (MeSH)
- Endocrine System - physiology
- Hormones - metabolism
- Specialty
- Endocrinology
- Notes
- "eReference"--Publisher.
- Abstract
- This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
- Contents
- The endocrine system -- Crosstalks between the endocrine, nervous and immune systems -- Hormone synthesis, secretion and transport -- Hormone receptors and signal transduction processes -- Mechanisms of control and termination of the hormonal action -- The classical endocrine system and endocrine glands -- The hypothalamus-pituitary axis -- The posterior pituitary -- The thyroid -- The parathyroids -- The adrenal glands -- The endocrine pancreas -- The testis -- The ovary -- Non-classical endocrine organs -- Hormone measurement and testing of endocrine function -- The endocrine regulation of energy and body weight -- The endocrine regulation of blood pressure -- The endocrine control of prenatal and neonatal growth -- Endocrinology of puberty -- The endocrine control of pregnancy -- Hormones and aging -- Principles of endocrine diseases -- Genetics and endocrine function -- Hormones and cancer.
- Format
- e-Book
- Location
- Online
Principles of Endocrinology and Hormone Action
https://libcat.nshealth.ca/en/permalink/provcat44562
edited by Antonino Belfiore, Derek LeRoith.
--Cham:
Springer
, c2017.
- Available Online
- View e-Book
- Location
- Online
This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, an…
- Available Online
- View e-Book
- Other Authors
- Belfiore, Antonino
- LeRoith, Derek
- Responsibility
- edited by Antonino Belfiore, Derek LeRoith
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2017
- Physical Description
- 1 online resource
- Series Title
- Springer reference
- Endocrinology
- ISBN
- 9783319273181
- ISSN
- 2510-1927
- Subjects (MeSH)
- Endocrine System - physiology
- Hormones - metabolism
- Specialty
- Endocrinology
- Notes
- "Living reference work."
- Abstract
- This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
- Contents
- Cytokine Receptors -- Endocrine Functions of Bone -- G Protein-Coupled Receptors -- Genetic Disorders of Adrenocortical Function -- Growth Hormones and Aging -- Molecular Mechanisms of Thyroid Hormone Synthesis and Secretion -- Nongenomic Actions of Thyroid Hormones -- Ovarian Physiology -- Steroid Hormone Receptors and Signal Transduction Processes -- Principles of Endocrine Diseases -- Receptor Tyrosine Kinases and the Insulin Signaling System -- Steroid Hormones: Synthesis, Secretion, and Transport -- Synthesis, Secretion and Transport of Peptide Hormones -- Targeting of Steroid Hormone Receptor Function in Breast and Prostate Cancer -- The Adrenal Glands -- The Endocrine Control of Human Pregnancy -- The Endocrine Gut -- The Endocrine Heart -- The Endocrine Pancreas -- The Endocrine Regulation of Blood Pressure -- The Endocrine Regulation of Energy and Body Weight -- The Endocrine System -- The Endocrinology of Puberty -- The Hypothalamus–Pituitary Axis -- The Parathyroids -- The Physiology of the Testis -- The Posterior Pituitary -- The Thyroid -- Thyroid Hormone Nuclear Receptors and Molecular Actions.
- Format
- e-Book
- Location
- Online
