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Advances in Nutrition and Cancer

https://libcat.nshealth.ca/en/permalink/provcat39632
Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione, editors. --Berlin, Heidelberg: Springer , c2014.
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This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed "nutrition and cancer" from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital inter…
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Other Authors
Zappia, Vincenzo
Panico, Salvatore
Russo, Gian Luigi
Budillon, Alfredo
Della Ragione, Fulvio
Other Authors
International Conference on Advances in Nutrition and Cancer (3rd : 2012 : Naples, Italy)
Responsibility
Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione, editors
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xiv, 460 p. : 59 illus., 34 illus. in color)
Series Vol.
159
Series Title
Cancer treatment and research
ISBN
9783642380075
9783642380068 (print ed.)
ISSN
0927-3042
Subjects (MeSH)
Feeding Behavior
Neoplasms - diet therapy
Neoplasms - etiology
Neoplasms - prevention & control
Abstract
This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed "nutrition and cancer" from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the "omics") that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions. Advances in Nutrition and Cancer will be an invaluable source of topical information for all researchers and clinicians with an interest in this field.
Contents
Part I: Life Style, Diet and Cancer -- The role of metabolic carcinogenesis in cancer causation and prevention: evidence from the European prospective investigation into cancer and nutrition -- Obesity, energy balance and cancer: a mechanistic perspective -- Fruits and vegetables. Updating the epidemiologic evidence for the WCRF-AICR lifestyle recommendations for cancer prevention -- The diet as a cause of human prostate cancer -- Mediterranean dietary pattern and chronic diseases -- Dietary salt intake and risk of gastric cancer -- Alcoholic beverages and carbonated soft drinks: consumption and gastrointestinal cancer risks -- Part II: Natural Dietary Molecules -- Anti-inflammatory and anti-cancer drugs from nature -- Selenium and cancer: a story that should not be forgotten--Insights from genomics -- Resveratrol: from basic studies to bedside -- Quercetin: a pleiotropic kinase inhibitor against cancer -- Sulforaphane as a promising molecule for fighting cancer -- Part III: Genetics and Epigenetics -- Functions, aberrations and advances for chromatin modulation in cancer -- Epigenetics and epidemiology: models of study and examples -- Dietary epigenetics in cancer and aging -- Breast cancer and the importance of early life nutrition -- Part IV: Olive Oil in Cancer Prevention -- Olive oil and other dietary lipids in breast cancer -- A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer -- Extra virgin olive oil: from composition to "molecular gastronomy" -- Part V: Life Style Prevention of Cancer -- Life style prevention of cancer recurrence: the yin and the yang -- Part VI: Emerging Breakthroughs -- New perspective for an old antidiabetic drug: metformin as anticancer agent -- Gut microbes, diet and cancer -- Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention -- Nutriomes and personalised nutrition for DNA damage prevention, telomere integrity maintenance and cancer growth control -- Novel approaches in melanoma prevention and therapy -- Concluding remarks.
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e-Book
Publication Type
Congress
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Basic sciences in ophthalmology : physics and chemistry

https://libcat.nshealth.ca/en/permalink/provcat32613
Josef Flammer, Maneli Mozaffarieh, Hans Bebie, authors. --Berlin, Heidelberg: Springer , c2013.
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Basic Sciences in Ophthalmology aims to link clinical ophthalmology directly to its basic science roots. This first volume describes the physics and chemistry required for a sound understanding of modern ophthalmology. The text guides the reader from short descriptions of historical background and basic introductions to recent aspects that are relevant in daily clinical practice. The eye is the organ that recognizes light, and most examinations and many treatments rely on light. Therefore, the …
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Author
Flammer, Josef
Other Authors
Mozaffarieh, Maneli
Bebie, Hans
Responsibility
Josef Flammer, Maneli Mozaffarieh, Hans Bebie, authors
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2013
Physical Description
1 online resource (xv, 250 p. : 441 ill., 396 ill. in color)
ISBN
9783642322617
Subjects (MeSH)
Chemistry
Diagnostic Techniques, Ophthalmological
Eye - anatomy & histology
Ophthalmology
Physics
Subjects (LCSH)
Medicine
Chemistry
Ophthalmology
Physics
Abstract
Basic Sciences in Ophthalmology aims to link clinical ophthalmology directly to its basic science roots. This first volume describes the physics and chemistry required for a sound understanding of modern ophthalmology. The text guides the reader from short descriptions of historical background and basic introductions to recent aspects that are relevant in daily clinical practice. The eye is the organ that recognizes light, and most examinations and many treatments rely on light. Therefore, the book starts with an extensive discussion of the nature of light, the interaction of light with matter, and the way in which light is used in ophthalmic examinations and treatments. After describing traditional methods of imaging, particular emphasis is placed on modern instrumentation such as OCT. This topic is complemented by discussion of other techniques including ultrasound, X-rays, and MRI. A comprehensive overview is devoted to the interaction between light and tissues in different types of laser treatment. The chemistry section focuses on compounds particularly relevant to the eye, such as oxygen and water. Special attention is also devoted to the origin and consequences of oxidative stress. Finally, the physical behavior of chemical compounds, such as gas or silicone oil, in the eye is explained. The complex material is made easy to understand through the use of many examples taken from the field of ophthalmology. The text is complemented by about 450 figures. This volume will be a great asset both to residents preparing for their basic science examination and to experienced professionals, including ophthalmologists and optometrists.
Contents
What is light?- The interaction between light and matter -- Light sources -- Examinations with light -- Ultrasound diagnostics -- Further imaging procedures -- Interventions with laser light -- Some history of chemistry -- Oxygen -- Water -- Carbon dioxide (CO2) -- Nitric oxide -- Redox reactions -- DNA -- RNA -- Proteins -- Lipids -- Matter: using water as an example -- If you are interested in more -- Appendix: Units and constants -- Index.
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e-Book
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Cardiac CT Imaging : Diagnosis of Cardiovascular Disease

https://libcat.nshealth.ca/en/permalink/provcat40081
Matthew J. Budoff, Jerold S. Shinbane, editors. (Third edition) --Cham: Springer , c2016.
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This book collates the current knowledge in cardiovascular CT and presents this in a clinically relevant and practical format appropriate for all who use the modality. The field has experienced continued rapid evolution due to advances in technology, the expanded spectrum of cardiovascular applications and significant growth in published data. As increasing numbers have access to CT scanners, Cardiac CT Imaging: Diagnosis of Cardiovascular Disease, Third Edition provides all the relevant inform…
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Other Authors
Budoff, Matthew J
Shinbane, Jerold S
Responsibility
Matthew J. Budoff, Jerold S. Shinbane, editors
Edition
Third edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xvi, 563 p. : 554 illus., 248 illus. in color)
ISBN
9783319282190
9783319282176 (print ed.)
Subjects (MeSH)
Cardiac Imaging Techniques - methods
Cardiovascular Diseases - diagnostic imaging
Radiography
Tomography, X-Ray Computed - methods
Abstract
This book collates the current knowledge in cardiovascular CT and presents this in a clinically relevant and practical format appropriate for all who use the modality. The field has experienced continued rapid evolution due to advances in technology, the expanded spectrum of cardiovascular applications and significant growth in published data. As increasing numbers have access to CT scanners, Cardiac CT Imaging: Diagnosis of Cardiovascular Disease, Third Edition provides all the relevant information on the use of this modality. This extensive revision of this well-respected textbook brings the reader up-to-date with the technique, with chapters supplied by an experienced set of contributing authors and representing the full spectrum of cardiac CT. It thus represents an essential purchase for those preparing for board examinations, all training to use this modality, and those already using cardiovascular CT on a day-to-day basis who want to stay current.
Contents
[publisher supplied] Computed Tomography -- Cardiovascular Computed Tomography: Current and Future Scanning System Design -- Radiation Safety: Radiation Dosimetry and CT Dose Reduction Techniques -- Assessment of Cardiovascular Calcium: Interpretation, Prognostic Value, and Relationship to Lipids and Other Cardiovascular Risk Factors -- Natural History and Impact of Interventions on Coronary Calcium -- The Aorta and Great Vessels -- Methodology for CCTA Image Acquisition -- Post processing and Reconstruction Techniques for the Coronary Arteries -- CTA Large Scale Trials -- Coronary CT Angiography: Native Vessels -- Coronary Angiography After Revascularization -- Assessment of Cardiac Structure and Function by Computed Tomography Angiography -- Perfusion and Delayed Enhancement Imaging -- Pericardial/Myocardial Disease Processes -- Computed Tomography Evaluation in Valvular Heart Disease -- Assessment of Cardiac and Thoracic Masses -- CT Angiography of the Peripheral Arteries -- Aortic, Renal, and Carotid CT Angiography -- Assessment of Pulmonary Vascular Disease -- Comparative Use of Radionuclide Stress Testing, Coronary Artery Calcium Scanning, and Noninvasive Coronary Angiography for Diagnostic and Prognostic Cardiac Assessment -- Cardiovascular Magnetic Resonance Imaging: Overview of Clinical Applications -- Computed Tomographic Angiography in the Assessment of Congenital Heart Disease -- CT Imaging: Cardiac Electrophysiology Applications -- An Interventionalist's Perspective: Diagnosis of Cardiovascular Disease -- CCTA: Cardiothoracic Surgery Applications -- Cardiac CT in the Emergency Room -- Orientation and Approach to Cardiovascular Images.
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e-Book
Location
Online
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Cardiorespiratory Fitness in Cardiometabolic Diseases : Prevention and Management in Clinical Practice

https://libcat.nshealth.ca/en/permalink/provcat44271
Peter Kokkinos, Puneet Narayan, editors. --Cham: Springer , 2019.
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This book examines the links between physical activity (PA), cardiorespiratory fitness (CRF), and cardiovascular and metabolic diseases. It presents an overview of the role of PA and CRF in the prevention and management of risk factors associated with cardiometabolic diseases such as hypertension, peripheral vascular disease, stroke, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, and atherosclerosis. In addition, it explores how these risks vary with different populations such as t…
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Kokkinos, Peter
Narayan, Puneet
Responsibility
Peter Kokkinos, Puneet Narayan, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (xiii, 443 p.) : 56 illus., 25 illus. in color
ISBN
9783030048167
9783030048150 (Print ed.)
9783030048174 (Print ed.)
Subjects (MeSH)
Cardiovascular Diseases - prevention & control
Cardiovascular System - physiology
Exercise - physiology
Metabolic Diseases - prevention & control
Physical Exertion - physiology
Physical Fitness - physiology
Respiratory System - physiology
Risk Factors
Stress, Physiological - physiology
Specialty
Cardiology
Physical Fitness
Abstract
This book examines the links between physical activity (PA), cardiorespiratory fitness (CRF), and cardiovascular and metabolic diseases. It presents an overview of the role of PA and CRF in the prevention and management of risk factors associated with cardiometabolic diseases such as hypertension, peripheral vascular disease, stroke, type 2 diabetes, metabolic syndrome, dyslipidemia, obesity, and atherosclerosis. In addition, it explores how these risks vary with different populations such as the elderly and people of various racial backgrounds. The book also highlights risks associated with exercise and presents a prescription for appropriate and efficacious exercise to minimize risk and maximize health benefits for the heart. Cardiorespiratory Fitness in Prevention and Management of Cardiometabolic Disease is an essential resource for physicians, exercise physiologists, medical students, residents, fellows, nurses, and researchers in cardiology, cardiorespiratory fitness, exercise science, health promotion and disease prevention, public health, and epidemiology.
Contents
1. Physical Activity, Cardiorespiratory Fitness, and Health: A Historical Perspective -- 2. Exercise, Gene Regulation, and Cardiometabolic Disease -- 3. Exercise and the Mitochondria -- 4. Effect of Exercise on Adult Stem Cells -- 5. Exercise Metabolism in Health and Disease -- 6. Exercise and the Endothelium -- 7. Exertion-Related Acute Cardiovascular Events: Pathophysiologic Considerations, Risk Modulators, and Prophylactic Interventions -- 8. Exercise and Blood Pressure Control in Hypertension -- 9. Role of Physical Activity, Exercise, and Cardiorespiratory Fitness in the Management of Resistant Hypertension -- 10. Physical Activity, Blood Pressure, and Cardiac Structure and Function -- 11. Physical Activity, Cardiorespiratory Fitness, and the Diabetes Spectrum -- 12. Cardiorespiratory Fitness, Physical Activity, and Metabolic Syndrome -- 13. Exercise Interventions in Patients with Diabetes and Peripheral Artery Disease -- 14. Physical Activity, Cardiorespiratory Fitness, and Obesity -- 15. The Obesity Paradox and Cardiorespiratory Fitness -- 16. Physical Activity, Exercise, and Lipids and Lipoproteins -- 17. Physical Activity, Fitness, and Coronary Heart Disease -- 18. Physical Activity and Cardiorespiratory Fitness in Heart Failure -- 19. Cardiorespiratory Fitness, Physical Activity, and Stroke -- 20. Cardiorespiratory Fitness, Physical Activity, and Incidence of Atrial Fibrillation -- 21. Chronic Kidney Disease and Physical Activity -- 22. Physical Activity, Fitness, and Sexual Dysfunction -- 23. Cardiorespiratory Fitness in the Context of Cardiac Rehabilitation -- 24. Physical Activity and Cardiometabolic Health Benefits in Children -- 25. Association Between Cardiorespiratory Fitness and Healthcare Costs.
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e-Book
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Cigarette Smoke and Oxidative Stress

https://libcat.nshealth.ca/en/permalink/provcat29150
editors, Barry B. Halliwell, Henrik E. Poulsen. --Berlin, Heidelberg: Springer-Verlag , c2006.
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Other Authors
Halliwell, Barry B.
Poulsen, Henrik E.
Responsibility
editors, Barry B. Halliwell, Henrik E. Poulsen
Place of Publication
Berlin, Heidelberg
Publisher
Springer-Verlag
Date of Publication
c2006
ISBN
9783540322320
Subjects (MeSH)
Tobacco Smoking - adverse effects
Tobacco Smoking - physiopathology
Oxidative Stress
Contents
1. Oxidative Stress -- 2. Tobacco Smoke Constituents Affecting Oxidative Stress -- 3. Oxidative Modifications of Proteins and Lipids by Cigarette Smoke (CS). A Central Role for Unsaturated Aldehydes in CS-Mediated Airway Inflammation -- 4. Cigarette Smoke-Induced Redox Signaling and Gene Expression in In Vitro and In Vivo Models -- 5. Redox Effects of Cigarette Smoke in Lung Inflammation -- 6. Oxidative Stress in the Pathogenesis of Chronic Obstructive Pulmonary Disease -- 7. Modulation of Cigarette Smoke Effects by Diet and Antioxidants -- 8. Modulation of Cigarette Smoke Effects by Antioxidants: Oxidative Stress and Degenerative Diseases -- 9. Smoking Depletes Vitamin C: Should Smokers Be Recommended to Take Supplements? -- 10. Experimental In Vitro Exposure Methods for Studying the Effects of Inhalable Compounds -- 11. Oxidative Stress in Laboratory Animals Exposed to Cigarette Smoke, with Special Reference to Chronic Obstructive Pulmonary Disease -- 12. Pulmonary Effects of Cigarette Smoke in Humans -- 13. Smoking and Oxidative Stress: Vascular Damage -- 14. Nrf2: a Transcription Factor that Modifies Susceptibility to Cigarette Smoke-Induced Pulmonary Oxidative Stress and Emphysema -- 15. Tobacco Smoke and Skin Aging -- 16. Cigarette Smoke and Oxidative DNA Modification.
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e-Book
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Clinical lipidology : a companion to Braunwald's heart disease

https://libcat.nshealth.ca/en/permalink/provcat33488
[edited by] Christie M. Ballantyne. (2nd ed.) --Philadelphia, PA: Elsevier Saunders , c2015.
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Clinical Lipidology, a companion to Braunwald’s Heart Disease, is designed to guide you through the ever-changing therapeutic management of patients with high cholesterol levels. From basic science to pathogenesis of atherothrombotic disease, to risk assessment and the latest therapy options, this medical reference book offers unparalleled coverage and expert guidance on lipidology in a straightforward, accessible, and user-friendly style.
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Other Authors
Ballantyne, Christie M
Responsibility
[edited by] Christie M. Ballantyne
Edition
2nd ed.
Place of Publication
Philadelphia, PA
Publisher
Elsevier Saunders
Date of Publication
c2015
Physical Description
1 online resource, 568 p.
ISBN
9780323324991
Subjects (MeSH)
Lipoproteins - metabolism
Cardiovascular Diseases - complications
Dyslipidemias
Lipid Metabolism
Subjects (LCSH)
Lipids
Lipoproteins
Heart - Diseases
Lipoproteins - metabolism
Cardiovascular Diseases - complications
Dyslipidemias
Lipid Metabolism
Notes
Complemented by: Braunwald's heart disease / edited by Douglas L. Mann, Douglas P. Zipes, Peter Libby, Robert O. Bonow, Eugene Braunwald. 10th edition. [2015]
Abstract
Clinical Lipidology, a companion to Braunwald’s Heart Disease, is designed to guide you through the ever-changing therapeutic management of patients with high cholesterol levels. From basic science to pathogenesis of atherothrombotic disease, to risk assessment and the latest therapy options, this medical reference book offers unparalleled coverage and expert guidance on lipidology in a straightforward, accessible, and user-friendly style.
Contents
Human plasma lipoprotein metabolism -- Regulation and clearance of apolipoprotein B-containing lipoproteins -- Absorption and excretion of intestinal cholesterol and other sterols -- High-density lipoprotein metabolism -- Lipoproteins : mechanisms for atherogenesis and progression of atherothrombotic disease -- Impact of rare and common genetic variants on lipoprotein metabolism -- Lipoprotein oxidation : mechanisms and biotheranostic applications -- Cholesterol : concentration, ratio, and particle number -- High-density lipoprotein cholesterol and triglycerides in coronary heart disease risk assessment -- Lipoprotein(a) -- Clinical evaluation for genetic and secondary causes of dyslipidemia -- Use of high-sensitivity c-reactive protein for risk assessment -- Role of lipoprotein-associated phospholipase A2 in vascular disease -- Emerging assays -- Imaging atherosclerosis for risk stratification by cardiac computed tomography or carotid ultrasound -- Overview of general approach to management of elevated low-density lipoprotein cholesterol and mixed dyslipidemia, high triglycerides, and low high-density lipoprotein cholesterol -- Treatment guidelines overview -- Dietary patterns for the prevention and treatment of cardiovascular disease -- Exercise and lipids -- Weight loss -- Statins -- Bile acid sequestrants -- Cholesterol absorption inhibitors -- Niacin (nicotinic acid) -- Fibrates -- Omega-3 fatty acids -- Combination therapy for dyslipidemia -- Nutraceuticals and functional foods for cholesterol reduction -- Evolving targets of therapy : cholesteryl ester transfer protein inhibition -- Evolving targets of therapy : proprotein convertase subtilisin/kexin 9 inhibition -- Evolving targets of therapy : inflammation as a method to predict and prevent cardiovascular events -- Invasive imaging modalities and atherosclerosis : intravascular ultrasound -- Noninvasive imaging modalities and atherosclerosis : the role of ultrasound -- Noninvasive imaging modalities and atherosclerosis : the role of magnetic resonance imaging and positron emission tomography imaging -- Special patient populations : diabetes and metabolic syndrome -- Special patient populations : women and elderly -- Special patient populations : children and adolescents -- Special patient populations : familial hypercholesterolemia and other severe hypercholesterolemias -- Special patient populations : acute coronary syndromes -- Special patient populations : transplant recipients -- Special patient populations : chronic kidney disease -- Special patient populations : lipid abnormalities in high-risk ethnic groups -- Special patient populations : human immunodeficiency virus patients -- Therapeutic targeting of high-density lipoprotein metabolism.
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Comprehensive Biochemistry for Dentistry : Textbook for Dental Students

https://libcat.nshealth.ca/en/permalink/provcat44220
Anil Gupta. --Singapore: Springer , 2019.
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This book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitam…
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Author
Gupta, Anil
Responsibility
Anil Gupta
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (xxxv, 604 p.) : 266 illus., 195 illus. in color
ISBN
9789811310355
9789811310348 (Print ed.)
9789811310362 (Print ed.)
Subjects (MeSH)
Biochemical Phenomena
Dentistry - education
Specialty
Biochemistry
Dentistry
Abstract
This book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitamins and hormones, enriched with flow charts and diagrams for easy understanding and quick reference. It includes chapters on nucleic acids, nutrition and serum enzymes and organ function tests, and offers an innovative approach to familiarize dental students with the biochemical composition of enamel, dentine, cementum and saliva, explaining the biochemical basis of dental caries, periodontal diseases, role of fluorides in caries prophylaxis, fluoride toxicity, and the role of amino acids as anti-hypersensitive agents.
Contents
Introduction to Biochemistry -- Part I. Cellular Biochemistry -- Cell and Organelles -- Part II. Structural Biochemistry -- Proteins and Amino acids -- Plasma Proteins -- Haemoglobin -- Carbohydrates -- Lipids -- Nucleic Acids -- Enzymes -- Hormones -- Vitamins -- Part III. Metabolism -- Digestion and Absorption of Proteins -- Metabolism of Proteins and Amino acids -- Digestion and Absorption of Carbohydrates -- Metabolism of Carbohydrates -- Digestion and Absorption of Lipids -- Metabolism of Lipids -- Metabolism of Minerals -- Biological Oxidation -- Part IV. Medical Biochemistry -- Acid-Base Balance -- Nutrition -- Serum Enzymes and Organ Function Tests -- Part: V Immunochemistry -- Immunoglobulins -- Part V. Dental Biochemistry -- Dental Biochemistry.
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e-Book
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Comprehensive lipid testing and management

https://libcat.nshealth.ca/en/permalink/provcat31048
Lars A. Carlson. --London: Springer Healthcare , c2011.
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Author
Carlson, Lars A
Responsibility
Lars A. Carlson
Place of Publication
London
Publisher
Springer Healthcare
Date of Publication
c2011
Physical Description
1 online resource (xi, 144 p. : 77 ill. in color)
ISBN
9781908517333
Subjects (MeSH)
Atherosclerosis - prevention & control
Coronary Disease - prevention & control
Dyslipidemias - therapy
Lipids - blood
Subjects (LCSH)
Cardiology
Contents
Part one. Lipid testing -- 1. Atherosclerosis and clinical atherosclerosis -- 2. From cholesterol to lipoproteins and apolipoproteins -- 3. Lipid testing -- 4. Lipid profiles -- 5. Lipid testing and prediction of coronary heart disease -- 6. Lipid risk factors in prediction of coronary heart disease: is any one factor best? -- Part two. Lipid management -- 7. Goals of lipid management -- 8. Cholesterol lowering and prevention of CHD -- 9. Cholesterol goals in current guidelines -- 10. Lipid management in clinical practice -- 11. Drugs for lipid management -- 12. Diabetic dyslipidaemia -- 13. LDL apheresis -- 14. Lipid modifying agents under development.
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e-Book
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Coronary Artery Disease

https://libcat.nshealth.ca/en/permalink/provcat38875
James T. Willerson, David R. Holmes, Jr., editors. --London: Springer , c2015.
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Coronary Artery Disease offers today's most up-to-date, user-friendly guidance on the evaluation, diagnosis, and medical and surgical treatment of this most important aspect of cardiovascular disease. The book provides comprehensive coverage of every aspect of coronary arterial medicine from cardiac signs and symptoms through imaging and the genetic basis for coronary disease to surgery, interventions, treatment and also to preventive cardiology. The Editors--and a group of contributing world a…
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Other Authors
Willerson, James T
Holmes, Jr., David R
Responsibility
James T. Willerson, David R. Holmes, Jr., editors
Place of Publication
London
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xiv, 783 p. : 464 illus., 277 illus. in color)
Series Title
Cardiovascular medicine
ISBN
9781447128281
9781447128274 (print ed.)
ISSN
2363-5053
Subjects (MeSH)
Coronary Artery Disease
Abstract
Coronary Artery Disease offers today's most up-to-date, user-friendly guidance on the evaluation, diagnosis, and medical and surgical treatment of this most important aspect of cardiovascular disease. The book provides comprehensive coverage of every aspect of coronary arterial medicine from cardiac signs and symptoms through imaging and the genetic basis for coronary disease to surgery, interventions, treatment and also to preventive cardiology. The Editors--and a group of contributing world authorities--offer their decades of scientific and clinical experience. The reader will have all the guidance to diagnose and manage a full range of conditions in a series of textbook resources.
Contents
1. Coronary Artery Disease: Pathological Anatomy and Pathogenesis -- 2. Clinical Use of Serum Biomarkers in the Prediction of Cardiovascular Risk -- 3. Medical Management of Serum Lipids and Coronary Heart Disease -- 4. Coronary Artery Disease: Regulation of Coronary Blood Flow -- 5. Coronary Angiography -- 6. Diabetes and Heart Disease -- 7. Women and Coronary Artery Disease -- 8. Exercise Testing -- 9. The Electrocardiogram in Coronary Artery Disease -- 10. Echocardiographic Evaluation of Coronary Artery Disease -- 11. Myocardial Perfusion Imaging Utilizing Single Photon Emission Computed Tomography Techniques -- 12. Clinical Cardiac Positron Emission Tomography -- 13. Magnetic Resonance Imaging of the Myocardium, Coronary Arteries, and Anomalous Origin of Coronary Arteries -- 14. Computed Tomograph Cardiovascular Imaging -- 15. Coronary Heart Disease Syndromes: Pathophysiology and Clinical Recognition -- 16. Evaluation of Vulnerable Atherosclerotic Plaques -- 17. Medical Treatment of Stable Angina -- 18. Medical Treatment of Unstable Angina and Acute Non-ST-Elevation Myocardial Infarction -- 19. Treatment of Acute ST-Elevation Myocardial Infarction -- 20. Medical Treatment of Heart Failure and Coronary Heart Disease -- 21. Surgical Treatment of Advanced Heart Failure -- 22. Kawasaki Disease -- 23. Percutaneous Coronary Intervention and the Various Coronary Artery Disease Syndromes -- 24. Sudden Cardiac Death in Coronary Artery Disease -- 25. Surgical Treatment of Coronary Artery Disease -- 26. Coronary Artery Bypass Surgery and Percutaneous Coronary Revascularization: Impact on Morbidity and Mortality in Patients with Coronary Artery Disease -- 27. Cardiovascular Genetics: Focus on Genetics of Coronary Artery Disease -- 28. Preventive Cardiology: The Effects of Exercise.
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e-Book
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Cytochrome P450 : Structure, Mechanism, and Biochemistry

https://libcat.nshealth.ca/en/permalink/provcat39136
Paul R. Ortiz de Montellano, editor. (4th edition) --Cham: Springer , c2015.
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This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volu…
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Ortiz de Montellano, Paul R
Responsibility
Paul R. Ortiz de Montellano, editor
Edition
4th edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (x, 912 p. : 243 illus., 80 illus. in color)
ISBN
9783319121086
9783319121079 (print ed.)
Subjects (MeSH)
Amino Acid Sequence
Cytochrome P-450 Enzyme System - chemistry
Cytochrome P-450 Enzyme System - physiology
Molecular Sequence Data
Abstract
This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.
Contents
1. Structures of Cytochrome P450 Enzymes -- 2. Electron Transfer Partners of Cytochrome P450 -- 3. Activation of Molecular Oxygen in Cytochromes P450 -- 4. Substrate Oxidation by Cytochrome P450 Enzymes -- 5. Inhibition of Cytochrome P450 Enzymes -- 6. Microbial Cytochromes P450 -- 7. P450s in Plants, Insects and their Fungal Pathogens -- 8. P450 Biotechnology -- 9. Human Cytochrome P450 Enzymes -- 10. Nuclear Receptor-Mediated Regulation of Cytochrome P450 Genes -- 11. Hormonal Regulation of Liver Cytochrome P450 Enzymes -- 12. P450 Enzymes in Steroid Processing -- 13. P450 Enzymes in Lipid Oxidation.
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e-Book
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Dermatoanthropology of Ethnic Skin and Hair

https://libcat.nshealth.ca/en/permalink/provcat41739
Neelam A. Vashi, Howard I. Maibach, editors. --Cham: Springer , 2017.
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Location
Online
Dermatoanthropology of Ethnic Skin and Hair is a comprehensive text that extensively examines cutaneous disease in persons with skin of color. The breadth of knowledge in this book encompasses the wide scope of dermatologic disease with 26 distinct and unique chapters. It serves as a guide to the diagnosis and treatment of skin disorders for those populations with darker skin types. Vashi and Maibach's Dermatoanthropology of Ethnic Skin and Hair provides an overview of medical, surgical, and co…
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Other Authors
Vashi, Neelam A
Maibach, Howard I
Responsibility
Neelam A. Vashi, Howard I. Maibach, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xiv, 492 pages) : 58 illus., 56 illus. in color
ISBN
9783319539614
9783319539607 (print ed.)
Subjects (MeSH)
Ethnic Groups
Skin Diseases - diagnosis
Skin Diseases - ethnology
Skin Diseases - therapy
Abstract
Dermatoanthropology of Ethnic Skin and Hair is a comprehensive text that extensively examines cutaneous disease in persons with skin of color. The breadth of knowledge in this book encompasses the wide scope of dermatologic disease with 26 distinct and unique chapters. It serves as a guide to the diagnosis and treatment of skin disorders for those populations with darker skin types. Vashi and Maibach's Dermatoanthropology of Ethnic Skin and Hair provides an overview of medical, surgical, and cosmetic dermatology in addition to providing an extensive anthropological and basic science background to fully understand skin disorders in persons of color. Topics of discussion include anthropology of skin and hair, biophysical properties of ethnic skin, structure and function of the skin, physiologic pigmentation, mucosal lesions, acne, rosacea, inflammatory disorders, infections, autoimmune disorders, connective tissue disease, hyperpigmentation, hypopigmentation and depigmentation, keloids, scarring, pediatric disease, alopecias, adnexal disorders, common cosmetic concerns and treatments, and cultural considerations.
Contents
1. The Anthropology of Skin Colors: An Examination of the Evolution of Skin Pigmentation and the Concepts of Race and Skin of Color -- 2. The Impact of Skin and Hair Disease in Ethnic Skin -- 3. Biophysical Properties of Ethnic Skin -- 4. Differences in Skin Structure and Function in Ethnic Populations -- 5. Photosensitivity and Photoreactivity in Ethnic Skin -- 6. Stratum Corneum Lipids and Water-Holding Capacity -- 7. Physiologic Pigmentation -- 8. Mucosal Lesions in Skin of Color -- 9. Acne and Rosacea -- 10. Inflammatory Disorders -- 11. Tinea Versicolor and Tinea Capitis -- 12. Autoimmune and Connective Tissue Disease in Skin of Color -- 13. Disorders of Hyperpigmentation -- 14. Disorders of Hypopigmentation and Depigmentation -- 15. Keloids and Hypertrophic Scarring -- 16. Skin Cancer -- 17. Pediatric Dermatology -- 18. The Anthropology of Human Scalp Hair -- 19. Alopecias and Disorders of the Hair Follicle -- 20. Adnexal Disorders -- 21. Skin Aging in Individuals with Skin of Color -- 22. Common Cosmetic Concerns and Approaches -- 23. Treatment Strategies for Hyperpigmentation -- 24. Chemical Peels in Ethnic Skin -- 25. Laser Treatment in Ethnic Skin -- 26. Cultural Considerations.
Format
e-Book
Location
Online
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Dyslipidemias : Pathophysiology, Evaluation and Management

https://libcat.nshealth.ca/en/permalink/provcat39039
Abhimanyu Garg, editor. --Totowa, NJ: Humana Press , c2015.
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Location
Online
Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, inte…
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Other Authors
Garg, Abhimanyu
Responsibility
Abhimanyu Garg, editor
Place of Publication
Totowa, NJ
Publisher
Humana Press
Date of Publication
c2015
Physical Description
1 online resource (xvi, 525 p. : 127 illus., 101 illus. in color)
Series
Contemporary Endocrinology
Series Title
Contemporary endocrinology (Totowa, N.J.)
ISBN
9781607614241
9781607614234 (print ed.)
Subjects (MeSH)
Dyslipidemias - physiopathology
Dyslipidemias - therapy
Abstract
Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication of the guidelines of National Cholesterol Education Program's Adult Treatment Panel and Pediatric Panel from the United States. These guidelines have stimulated generation of similar recommendations from all over the world, particularly Europe, Canada, Australia and Asia. Developed by a renowned group of leading international experts, the book offers state-of-the-art chapters that are peer-reviewed and represent a comprehensive assessment of the field. A major addition to the literature, Dyslipidemias: Pathophysiology, Evaluation and Management is a gold-standard level reference for all clinicians who are challenged to provide the best care and new opportunities for patients with dyslipidemias.
Contents
Lipoprotein Physiology -- Epidemiology of Blood Lipids and Lipoproteins -- Lipoprotein(a) -- Lipoproteins and Cardiovascular Disease Risk -- Detection and Treatment of Children and Adolescents with Dyslipidemia -- Type 2 Diabetes Mellitus and Dyslipidemia -- Type 1 Diabetes Mellitus and Dyslipidemia -- Dyslipidemia in Chronic Kidney Disease and Nephrotic Syndrome -- Dyslipidemia in HIV-infected Patients -- Monogenic Hypercholesterolemias -- Primary Hypertriglyceridemia -- Genetic Disorders of HDL Metabolism -- Sitosterolemia and Other Rare Sterol Disorders -- Genetic Abetalipoproteinemia & Hypobetalipoproteinemia -- Drug-induced Dyslipidemia -- Lipodystrophies and Dyslipidemias -- Novel Genes for Dyslipidemias: Genome-Wide Association Studies -- Perspectives on Cholesterol Guidelines -- Nutrition and Coronary Heart Disease Prevention -- Phytosterol Therapy -- N-3 Fatty Acids: Role in Treating Dyslipidemias and Preventing Cardiovascular Disease -- Polyphenols for Cholesterol Management -- Dietary Supplements for Cholesterol Management -- Statins: Risk-Benefits and Role in Treating Dyslipidemias -- Fibrates: Risk-Benefits and Role in Treating Dyslipidemias -- Niacin: Risk-Benefits and Role in Treating Dyslipidemias -- Bile Acid Sequestrants: Risk-Benefits and Role in Treating Dyslipidemias -- Cholesterol Absorption Inhibitor-Ezetimibe: Risk-Benefits and Role in Treating Dyslipidemias -- Low Density Lipoprotein (LDL) Apheresis -- Novel Lipid Lowering Agents.
Format
e-Book
Location
Online
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Essential revison notes for cardiology KBA

https://libcat.nshealth.ca/en/permalink/provcat25798
edited by Ali Khavandi. --Oxford, UK: Oxford University Press , c2014.
Call Number
WG 18.2 E78e 2014
Location
Halifax Infirmary
The first revision text aimed specifically at the Knowledge-Based Assessment, Essential Revision Notes for Cardiology KBA exactly maps the core cardiology training curriculum to provide a clearly structured and easily accessible guide to this now-compulsory examination.
Call Number
WG 18.2 E78e 2014
Other Authors
Khavandi, Ali
Responsibility
edited by Ali Khavandi
Alternate Title
Essential revison notes for cardiology knowledge based assessment
Place of Publication
Oxford, UK
Publisher
Oxford University Press
Date of Publication
c2014
Physical Description
579 p.
ISBN
9780199654901
Subjects (MeSH)
Cardiology - Examination Questions
Abstract
The first revision text aimed specifically at the Knowledge-Based Assessment, Essential Revision Notes for Cardiology KBA exactly maps the core cardiology training curriculum to provide a clearly structured and easily accessible guide to this now-compulsory examination.
Contents
1. Chest Pain ; 2. Acute Coronary Syndromes and Myocardial Infarction ; 3. Heart Failure ; 4. Cardiomyopathy ; 5. Valvular Heart Disease ; 6. Syncope ; 7. SVT ; 8. Ventricular Tachycardia ; 9. Atrial Fibrillation ; 10. The Pericardium ; 11. Prevention ; 12. Hypertension ; 13. Lipids ; 14. Adult Congenital Heart Disease ; 15. Endocarditis ; 16. Aortic Disease ; 17. Cardiac Tumours ; 18. Cardiac Rehabilitation ; 19. Assessment of Patients with Cardiac Disease Prior to Non-Cardiac Surgery ; 20. Assessment of Patients with Cardiac Disease Prior to Cardiac Surgery ; 21. Management of Critically Ill and Hameodynamic ; 22. Pregnancy ; 23. Radiation Use and Safety ; 24. Community Cardiology ; 25. Pulmonary Hypertension ; 26. Genetics ; 27. Nuclear ; 28. MRI ; 29. CCT ; 30. Heart Rhythm ; 31. Invasive and Interventional Cardiology.
Format
Book
Location
Halifax Infirmary
Copies
1
Loan Period
3 weeks
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Essentials of Mini One Anastomosis Gastric Bypass

https://libcat.nshealth.ca/en/permalink/provcat42953
edited by Mervyn Deitel. --Cham: Springer , c2018.
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Location
Online
This book indicates the technique and fine points of the mini- and one-anastomosis gastric bypass, and looks at the means of revising other operations related to it. The chapters discuss postoperative complications, treatment and requirements, postoperative diet and medications, the remarkable effects on the co-morbidities of morbid obesity, and the durability of the weight loss, as well as the improvement in the quality of life. Essentials of Mini One Anastomosis Gastric Bypass aims to help su…
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Other Authors
Deitel, Mervyn
Responsibility
edited by Mervyn Deitel
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xv, 371 p.) : 176 illus., 166 illus. in color
ISBN
9783319761770
9783319761763 (print ed.)
9783319761787 (print ed.)
Subjects (MeSH)
Gastric Bypass - methods
Laparoscopy
Obesity, Morbid - surgery
Specialty
Bariatric Medicine
Surgical Procedures, Operative
Abstract
This book indicates the technique and fine points of the mini- and one-anastomosis gastric bypass, and looks at the means of revising other operations related to it. The chapters discuss postoperative complications, treatment and requirements, postoperative diet and medications, the remarkable effects on the co-morbidities of morbid obesity, and the durability of the weight loss, as well as the improvement in the quality of life. Essentials of Mini One Anastomosis Gastric Bypass aims to help surgeons manage the difficulties encountered within this procedure and to help create improved practice.
Contents
A Brief History of Bariatric Surgery to the Present -- Understanding the Technique of MGB: Clearing the Confusion -- Physiology of the MGB: How it Works for Long-term Weight Loss -- Ten Crucial Steps for the MGB Operation -- The Ideal Length of the Jejunal Limb in MGB -- Perioperative Care in the MGB and Anesthetic Management -- Early Complications of the MGB Çô Prevention and Treatment -- Late Complications of the MGB—Prevention and Treatment -- Diet, Supplements and Medications after MGB. Nutritional Outcomes. Avoidance of Iron Deficiency. MGB in Vegetarians -- Patient Contraindications to Undergoing MGB -- Understanding the Morbidly Obese Patient -- Effects of MGB on Obesity-Related Co-Morbidities—Lipids, Hypertension, Non-alcoholic Fatty Liver, etc -- Effects of MGB on Type 2 Diabetes in Morbid Obesity. Comparison with the Other Operations -- Effects of MGB on Type 2 Diabetes in Lower BMI Patients -- Effect of MGB on the Obese Type 1 Diabetic -- The Question of Gastro-esophageal Reflux -- Treatment of Marginal Ulcer -- Quality of Life after MGB Compared to Other Operations -- Use of Single or Reduced Number of Ports -- Robotic MGB -- Absence of Gastric and Esophageal Carcinoma after MGB -- Revision of Lap-band to MGB -- Comparison of Results of MGB to Sleeve Gastrectomy and Roux-en-Y Gastric Bypass. Technique of Conversion of Failed Sleeve Gastrectomy to MGB -- Anti-reflux One-Anastomosis Gastric Bypass (OAGB) [Spanish BAGUA]: Step-by-step Technique, Rationale and Bowel Lengths -- Results of the OAGB: Effects on Co-Morbidities, Diabetes, Weight and Quality of Life, Nutritional Considerations, Pregnancy -- Results of the OAGB in Adolescents -- Physical Principles Applied to the OAGB -- Method of Revision of Sleeve Gastrectomy to OAGB -- The Ileal Food Diversion Operation: Technique, Rationale and Results -- Diverted MGB: A New Procedure -- Comparison of MGB with SADI-S: Revision of Sleeve Gastrectomy to MGB or Single Anastomosis Duodeno-Ileostomy (SADI) -- Single Anastomosis Gastro-ileal Bypass (SAGI) -- The MGB-OAGB International Club.
Format
e-Book
Location
Online
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Filaggrin : basic science, epidemiology, clinical aspects and management

https://libcat.nshealth.ca/en/permalink/provcat33854
Jacob P. Thyssen, Howard I. Maibach, editors. --Heidelberg: Springer , c2014.
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Location
Online
Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever,…
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Other Authors
Thyssen, Jacob P.
Maibach, Howard I.
Responsibility
Jacob P. Thyssen, Howard I. Maibach, editors
Place of Publication
Heidelberg
Publisher
Springer
Date of Publication
c2014
Physical Description
1 online resource (xv, 373 pages)
ISBN
9783642543791 (electronic bk.)
9783642543784
Subjects (MeSH)
Intermediate Filament Proteins
Subjects (LCSH)
Skin - Diseases - Genetic aspects
Medical genetics
Abstract
Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.
Contents
Part I. Basic Science -- Function of Filaggrin and Its Metabolites -- Morphology of Filaggrin-Depleted Epidermis -- Stratum Corneum Lipids and Filaggrin -- Inflammatory-Driven Depletion of Filaggrin Proteins -- Immune Activity and Vitamin D -- Filaggrin-2 -- Part II. Identification and Study Methods -- Animal Models -- In Vitro Models of Filaggrin-Associated Diseases -- Mapping Posttranslational Regulation of Filaggrin Using Phosphoproteomics -- Noninvasive Detection of Filaggrin Molecules by Raman Spectroscopy -- Filaggrin Genotyping -- Part III. Epidemiology and Environmental Exposures -- Prevalence of Filaggrin Gene Mutations: An Evolutionary Perspective -- Filaggrin Gene Mutations in Asian Races -- Filaggrin Gene Loss-of-Function Mutations and Exposure to Endocrine Disrupting Environmental Chemicals -- Part IV. Filaggrin and Atopic Disease -- Filaggrin Mutations and the Atopic March -- Atopic Dermatitis -- Asthma -- Filaggrin Mutations, Skin Barrier Dysfunction, and Sensitization in Allergic Rhinitis -- Filaggrin and Non-cutaneous Disease: Food Allergy -- Filaggrin in Canine Skin -- Part V. Filaggrin and Cutaneous Disease -- Ichthyosis Vulgaris and Other Disorders of Cornification -- Xerosis Means "Dry Skin": Mechanisms, Skin Conditions, and Its Management -- Allergic Contact Dermatitis -- Irritant Contact Dermatitis -- Hand Eczema -- Filaggrin in Psoriasis -- Filaggrin and Skin Infections -- Atopic Dermatitis and Skin Cancer -- Filaggrin Gene Mutations: A Clinician's Perspective -- Part VI. Filaggrin and Non-cutaneous Disease -- Filaggrin, the Skin Barrier, and Diabetes -- The Eye and Filaggrin -- Filaggrin Dysfunction and Its Association with Inflammatory Conditions of the GI Tract -- Filaggrin, Human Papillomavirus, and the Cervix -- Antibodies Against Citrullinated Proteins and Filaggrin -- Filaggrin and the Oral Mucosa -- Part VII. Management -- Therapeutics and Other Interventions.
Format
e-Book
Location
Online
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Handbook of Outpatient Medicine

https://libcat.nshealth.ca/en/permalink/provcat43388
Elana Sydney, Eleanor Weinstein, Lisa M. Rucker, editors. --Cham: Springer , c2018.
Available Online
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Location
Online
This handbook provides a quick, portable, algorithm-based guide to diagnosis and management of common problems seen in adult patients. Written by experienced primary care practitioners, the book emphasizes efficient decision making necessary in the fast-paced realm of the medical office. It covers general considerations such as the physical examination, care of special populations, and pain management and palliative care. It also focuses on common symptoms and disorders by system, including end…
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Other Authors
Sydney, Elana
Weinstein, Eleanor
Rucker, Lisa M.
Responsibility
Elana Sydney, Eleanor Weinstein, Lisa M. Rucker, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xvii, 578 p.) : 80 illus., 62 illus. in color
ISBN
9783319683799
9783319683782 (print ed.)
9783319683805 (print ed.)
Subjects (MeSH)
Ambulatory Care - methods
Clinical Decision-Making
Specialty
General Practice
Patient Care
Abstract
This handbook provides a quick, portable, algorithm-based guide to diagnosis and management of common problems seen in adult patients. Written by experienced primary care practitioners, the book emphasizes efficient decision making necessary in the fast-paced realm of the medical office. It covers general considerations such as the physical examination, care of special populations, and pain management and palliative care. It also focuses on common symptoms and disorders by system, including endocrine, respiratory, cardiac, orthopedic, neurologic, genitourinary, and gynecologic. For each disorder, symptoms, red flags, algorithms for differential diagnosis, related symptoms and findings, laboratory workup, treatment guidelines, and clinical pearls are discussed. Handbook of Outpatient Medicine is a valuable resource for primary care physicians, residents, and medical students.
Contents
Part I. General Considerations -- Physical exam/Screening/Health maintenance -- Transition care of teens with chronic health conditions -- Home care/Care of elderly -- End-of-life care/Pain management/Palliative -- Care of HIV patients -- Part II. Endocrine -- Diabetes -- Lipids -- Thyroid dysfunction -- Obesity -- Part III. Respiratory -- Cough -- Shortness of breath -- Sinusitis -- Sore throat -- Sleep apnea -- Part IV. Cardiac -- Hypertension -- Chest pain -- Anemia -- Edema -- Part V. Dermatologic -- Rash -- Hair loss -- Part VI. Orthopedic -- Knee pain -- Shoulder pain -- Back pain -- Part VII. Neurologic -- Dizziness -- Headache -- Part VIII. Gynecologic -- Vaginal discharge -- Contraception -- Part IX. Genitourinary -- Dysuria -- Renal insufficiency -- Prostate problems -- Part X Gastroenterologic -- Abdominal pain -- Abnormal liver tests -- Part XI. Psychiatric -- Depression/Anxiety -- Insomnia -- Memory loss/Cognitive impairment.
Format
e-Book
Publication Type
Handbook
Location
Online
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Inborn Metabolic Diseases : Diagnosis and Treatment

https://libcat.nshealth.ca/en/permalink/provcat40382
Jean-Marie Saudubray, Matthias R. Baumgartner, John Walter, editors. (6th edition) --Berlin, Heidelberg: Springer , c2016.
Available Online
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Location
Online
This work is recognised as the standard textbook for professionals involved in the diagnosis and management of inborn errors of metabolism (IEM) and an essential resource in this multidisciplinary field. For the 6th edition all 43 chapters have been newly written or revised by authors with particular expertise in their subject areas. Contents A clinical and biochemical approach to the recognition and diagnosis of IEM with algorithms to symptoms, signs, and syndromes in patients of all ages; Eme…
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Other Authors
Saudubray, Jean-Marie
Baumgartner, Matthias R
Walter, John
Responsibility
Jean-Marie Saudubray, Matthias R. Baumgartner, John Walter, editors
Edition
6th edition
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2016
Physical Description
1 online resource (xxxi, 658 p.)
ISBN
9783662497715
9783662497692 (print ed.)
Subjects (MeSH)
Metabolism, Inborn Errors - diagnosis
Metabolism, Inborn Errors - therapy
Abstract
This work is recognised as the standard textbook for professionals involved in the diagnosis and management of inborn errors of metabolism (IEM) and an essential resource in this multidisciplinary field. For the 6th edition all 43 chapters have been newly written or revised by authors with particular expertise in their subject areas. Contents A clinical and biochemical approach to the recognition and diagnosis of IEM with algorithms to symptoms, signs, and syndromes in patients of all ages; Emergency treatments; Medications. Separate comprehensive sections on IEM of: Carbohydrates; Mitochondrial Energy; Amino and organic acids; Vitamin-responsive defects; Neurotransmitter and Small peptides, Lipid and Bile Acids; Nucleic Acid and Heme; Organelles. Disorders affecting the synthesis and remodelling of complex lipids and fatty acid homeostasis are now included. The Editors Jean-Marie Saudubray, M.D., is Emeritus Professor of Pediatrics and Expert Metabolic Consultant at the adult neuro-metabolic unit in the H©þpital La Piti© Salp©tri© re from the Université Pierre et Marie Curie, Paris. Matthias R. Baumgartner, M.D., Professor of Paediatrics and Inherited Metabolic Medicine, University of Zurich, is Head of the Division of Metabolism and the Swiss Newborn Screening Programme at the University Children's Hospital, Zurich. John Walter, M.D. is Honorary Clinical Professor of Inherited Metabolic Medicine, Manchester Academic Health Science Centre, Willink Unit, Manchester.
Contents
Section I. Diagnosis and Treatment: General Principles -- Section II. Disorders of Carbohydrate Metabolism -- Section III. Disorders of Mitochondrial Energy Metabolism -- Section IV. Disorders of Amino Acid Metabolism and Transport -- Section V. Vitamin-Responsive Disorders -- Section VI. Neurotransmitter and Small Peptide Disorders -- Section VII. Disorders of Lipid and Bile Acid Metabolism -- Section VIII. Disorders of Nucleic and Heme Metabolism -- Section IX. Disorders of Metal Transport -- Section X. Organelle-Related Disorders: Lysosomes, Peroxisomes, and Golgi and Pre-Golgi Systems -- Section XI. Appendices.
Format
e-Book
Location
Online
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Informing Clinical Practice in Nephrology : The Role of RCTs

https://libcat.nshealth.ca/en/permalink/provcat39111
Mohsen El Kossi, Arif Khwaja, A. Meguid El Nahas, editors. --Cham: Springer , c2015.
Available Online
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Location
Online
This book offers a thorough and critical appraisal and evaluation of the key published clinical trials that have shaped current practice in nephrology, dialysis and transplantation. It will help the practicing physician close the gap between the inflexible and generalized nature of clinical guidelines and the day-to-day clinical decision-making for individual patients. Furthermore, it will provide clinicians with the tools required to investigate and extract the appropriate guidance to apply to…
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Other Authors
El Kossi, Mohsen
Khwaja, Arif
El Nahas, A. Meguid
Responsibility
Mohsen El Kossi, Arif Khwaja, A. Meguid El Nahas, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xii, 243 p. : 1 illus.)
ISBN
9783319102924
9783319102917 (print ed.)
Subjects (MeSH)
Kidney Diseases
Randomized Controlled Trials as Topic
Abstract
This book offers a thorough and critical appraisal and evaluation of the key published clinical trials that have shaped current practice in nephrology, dialysis and transplantation. It will help the practicing physician close the gap between the inflexible and generalized nature of clinical guidelines and the day-to-day clinical decision-making for individual patients. Furthermore, it will provide clinicians with the tools required to investigate and extract the appropriate guidance to apply to individual and often complex cases encountered in daily practice. Lastly, it will improve the ability of junior colleagues to appraise available evidence in a systematic way when there is lack of local guidelines or when the guidelines are difficult to apply due to logistic constraints or barriers. Informing Clinical Practice in Nephrology: The Role of RCTs is an essential reference text for renal specialists, nephrologists in training, transplant and renal surgeons as well as, researchers in renal medicine, intensivists specializing in acute kidney injury (AKI), immunologists, general practitioners and other clinicians who are interested in chronic kidney disease (CKD).
Contents
[publisher supplied] Management of ADPKD -- Secondary Glomerular Disease Lupus Nephritis -- ANCA-Associated Vasculitis -- Acute Kidney Injury -- Chronic Kidney Disease -- Anaemia in Chronic Kidney Disease (CKD) -- Lipids and Chronic Kidney Disease -- Chronic Kidney Disease with Mineral and Bone Disorder (CKD-MBD) -- Diabetic Nephropathy -- Primary Glomerular Disease -- Hemodialysis -- Peritoneal Dialysis -- Transplantation.
Format
e-Book
Location
Online
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Klinefelter’s Syndrome : From a Disabling Condition to a Variant of Normalcy

https://libcat.nshealth.ca/en/permalink/provcat45482
Andrea Garolla, Giovanni Corona, editors. --Cham: Springer , c2020.
Available Online
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Location
Online
This book presents the latest insights into all the critical aspects of Klinefelter’s Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more “evidence-based” support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.
Available Online
View e-Book
Other Authors
Garolla, Andrea
Corona, Giovanni
Responsibility
Andrea Garolla, Giovanni Corona, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xi, 232 p.) : 10 illus., 6 illus. in color
Series Title
Trends in andrology and sexual medicine
ISBN
9783030514105
9783030514099 (Print ed.)
9783030514112 (Print ed.)
9783030514129 (Print ed.)
ISSN
2367-0088
Subjects (MeSH)
Klinefelter Syndrome
Specialty
Endocrinology
Men's Health
Reproductive Medicine
Abstract
This book presents the latest insights into all the critical aspects of Klinefelter’s Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more “evidence-based” support, and improving patient satisfaction. It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.
Contents
1. Introduction: From a Disabling Condition to a Variant of Normalcy -- 2. Epidemiology of an Underdiagnosed Syndrome -- 3. Causes of Extra Chromosome(s) -- 4. Different Karyotypes, Same Disease? -- 5. Genetic and Epigenetic Aspects of the Supernumerary X Chromosome -- 6. Prenatal Counselling and Management in the Early Neonatal Period -- 7. Early Developmental Pathways and Communication Good Practices -- 8. The Diagnosis of Klinefelter Syndrome at Prepubertal Age -- 9. The Pediatric Management of Klinefelter Syndrome: What to Do and When from Infancy to Puberty -- 10. Klinefelter Syndrome: From a Disabling Condition to a Variant of Normalcy: Neuropsychiatric Aspects -- 11. Testicular Development -- 12. The Klinefelter Puberty -- 13. Genetic of Gametes -- 14. Phenotype of the Adulthood -- 15. Hypothalamic–Pituitary Axis Function -- 16. Klinefelter Syndrome: The Altered Bone -- 17. Obesity: The Rule or Not -- 18. Lipids and Glucose Metabolism -- 19. Klinefelter Syndrome: Cardiovascular Characteristics -- 20. The Thyroid Function -- 21. Oncological Problems -- 22. Fertility Preservation -- 23. Fertility Versus Infertility -- 24. Psychological Features -- 25. Sexual Function -- 26. Testosterone Treatment in Male Patients with Klinefelter’s Syndrome.
Format
e-Book
Location
Online
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Leptin : Regulation and Clinical Applications

https://libcat.nshealth.ca/en/permalink/provcat39108
Sam Dagogo-Jack, MD, editor. --Cham: Springer , c2015.
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Location
Online
Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicat…
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Other Authors
Dagogo-Jack, MD, Sam
Responsibility
Sam Dagogo-Jack, MD, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xxiii, 287 p. : 48 illus., 27 illus. in color)
ISBN
9783319099156
9783319099149 (print ed.)
Subjects (MeSH)
Leptin - physiology
Leptin - therapeutic use
Abstract
Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.
Contents
[publisher supplied] Discovery of leptin and elucidation of leptin gene expression -- Leptin receptors and mechanism of action -- Leptin interaction with brain orexigenic and anorexigenic pathways -- Measurement of circulating leptin and soluble leptin receptors -- Physiological and hormonal factors that influence leptin production -- Leptin, obesity and leptin resistance -- Leptin and intermediary metabolism: Focus on glucoregulation and lipids -- Leptin in acute stress -- Leptin and the kidney -- Leptin, immune function, and inflammation -- Leptin and bone -- Leptin, cell cycle, and cancer -- Leptin, the autonomic nervous system, and hypertension -- Dynamic leptin secretion in obesity and diabetes -- Leptin therapy of congenital leptin deficiency -- Leptin therapy in people with normal leptin gene -- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance -- Leptin therapy in women with hypothalamic amenorrhea -- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans -- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases.
Format
e-Book
Location
Online
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