Neurodegenerative diseases : neurobiology, pathogenesis, and therapeutics
https://libcat.nshealth.ca/en/permalink/provcat27215
[edited by] M. Flint Beal, Anthony E. Lang, Albert C. Ludolph.
--Cambridge, UK:
Cambridge University Press
, c2005.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Beal, M. Flint
- Other Authors
- Lang, Anthony E
- Ludolph, Albert C
- Responsibility
- [edited by] M. Flint Beal, Anthony E. Lang, Albert C. Ludolph
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- c2005
- Physical Description
- xxii, 985 p.
- ISBN
- 6610162689 (electronic bk.)
- Subjects (MeSH)
- Neurodegenerative Diseases
- Contents
- Cover -- Half-Title -- Title -- Copyright -- Contents -- Preface -- Contributors -- Part I Basic aspects of neurodegeneration -- 1 Endogenous free radicals and antioxidants in the brain -- Formation of oxygen free radicals -- Low-molecular weight scavengers -- Exogenous -- Antioxidant proteins and enzymes -- Markers of free radical damage -- Cellular and histochemical analyses -- REFERENCES -- 2 Biological oxidants and therapeutic antioxidants -- Introduction -- Why is identification of reactive species and biomolecular targets so difficult? -- 3 Mitochondria, metabolic inhibitors and neurodegeneration -- Mitochondrial energy production and sites of action for metabolic inhibitors -- Mitochondrial calcium homeostasis -- Mitochondrial free radical production -- Mitochondrial permeability transition -- Mitochondria and cell death: necrosis -- Mitochondrial and cell death: apoptosis -- Mitochondrial inhibition and neurodegeneration -- Concluding remarks -- REFERENCES -- 4 Excitotoxicity and excitatory amino acid antagonists in chronic neurodegenerative diseases -- Introduction -- Excitotoxicity and neurodegenerative diseases -- Excitotoxicity and Parkinson's disease -- Huntington's disease -- Glutamate in Alzheimer's disease -- Amyotrophic lateral sclerosis -- Conclusions -- REFERENCES -- 5 Glutamate transporters -- Introduction -- High affinity, Na+-dependent glutamate transporters: localization, functional properties and topology -- Regulation of glutamate transporters -- Excitatory neurotransmission and glutamate transporters -- Excitotoxicity and glutamate transporters -- Neurodegenerative diseases and glutamate transporters -- Concluding remarks -- REFERENCES -- 6 Calcium binding proteins in selective vulnerability of motor neurons -- Introduction -- Increased calcium in motor neurons in ALS -- Cellular calcium homeostasis and calcium binding proteins -- Calcium binding proteins in motor neurons -- AMPA/kainate receptors and selective vulnerability -- Mechanism of protection of motor neurons by calcium binding proteins: axon terminals -- Mechanism of protection of motor neurons by calcium binding proteins: cell bodies -- In vitro transfection study -- In vivo studies -- Stress-related changes of CaBPs in motoneurons and glial cells -- Neuroprotective role of CaBPs in other systems -- Conclusions: calcium-mediated degeneration of motor neurons -- Acknowledgements -- REFERENCES -- 7 Apoptosis in neurodegenerative diseases -- Introduction -- Evidence for apoptosis and caspase activation in human diseases -- Caspase inhibition and inflammation -- Limitations and cautions -- REFERENCES -- 8 Neurotrophic factors -- Introduction -- Developmental motoneuron cell death -- Neurotrophic factors for motoneurons -- Identification of cellular signaling pathways responsible for neurotrophic factor mediated survival of motoneurons -- The role of neuronal activity and glutamate for motoneuron survival -- An active role of NGF signaling in motoneuron cell death? -- Downstream signals which mediate the neuronal survival response to neurotrophins and CNTF: the role of members of the IAP family -- Animal models
- Format
- e-Book
- Location
- Online
Cardiovascular Biomarkers : Pathophysiology and Disease Management
https://libcat.nshealth.ca/en/permalink/provcat30100
edited by David A. Morrow.
--Totowa, NJ:
Humana Press
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Morrow, David A
- Responsibility
- edited by David A. Morrow
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2006
- Series Title
- Contemporary cardiology (Totowa, N.J. : Unnumbered)
- ISBN
- 9781597450515
- Subjects (MeSH)
- Biological Markers
- Heart Diseases - therapy
- Subjects (LCSH)
- Cardiology
- Biochemistry
- Physiology
- Format
- e-Book
- Location
- Online
The clinical neuropsychiatry of stroke
https://libcat.nshealth.ca/en/permalink/provcat27241
Robinson, Robert G.
(2nd ed.)
--Cambridge, UK:
Cambridge University Press
, 2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Robinson, Robert G
- Edition
- 2nd ed.
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- 2006
- Physical Description
- 470 p.
- ISBN
- 6610414327
- Subjects (MeSH)
- Stroke - complications
- Mental Disorders - etiology
- Contents
- Cover -- Contents -- Preface -- REFERENCE -- Part I Introduction -- 1 Recent trends in the epidemiology of stroke -- REFERENCES -- 2 Historical perspective -- REFERENCES -- 3 Brain organization and cerebral basis of emotion -- REFERENCES -- 4 Vascular anatomy and classification of stroke -- Carotid system -- Vertebral...basilar system -- Venous system -- Classification of cerebrovascular disease -- Other types of cerebrovascular disease -- REFERENCES -- Part II Poststroke depression -- 5 Diagnosis of depression -- Method of diagnosis -- Applicable diagnostic categories -- Reliability and validity of diagnoses -- Other diagnostic categories -- REFERENCES -- 6 Prevalence of depressive disorders -- REFERENCES -- 7 Phenomenology and specificity of depressive symptoms -- REFERENCES -- 8 Natural course of depression -- REFERENCES -- 9 Delayed-onset depression -- REFERENCES -- 10 Relationship to lesion location -- Background -- Effects of interhemispheric and intrahemispheric lesion location -- Changes over time in lesion locations associated with depression -- Correlation between the severity of depression and anterior...posterior lesion location -- Relationship between depression and MCA versus posterior circulation -- REFERENCES -- 11 Relationship of depression to cerebral dominance and structural asymmetries -- Background -- Patients with left sided motor dominance -- Patients with typical and reversed brain asymmetries -- REFERENCES -- 12 Relationship of depression to bilateral hemisphere brain injury -- REFERENCES -- 13 Relationship of depression to physical impairment -- Background -- The relationship between severity of depression and severity of physical impairment -- The effect of depression on recovery in ADL -- Effect of treatment on recovery in physical impairment -- REFERENCES -- 14 Relationship to cognitive impairment and treatment -- Cognitive impairment and stroke -- Cognitive impairment and depression -- Effects of depression versus effects of lesion -- Longitudinal course of cognitive impairment and depression -- Effect of antidepressant treatment on cognitive function -- Longitudinal course -- Mechanism of cognitive impairment -- REFERENCES -- 15 Relationship of aphasia to depression -- REFERENCES -- 16 Relationship of depression to social functioning -- REFERENCES -- 17 Relationship to premorbid risk factors -- REFERENCES -- 18 Mortality and treatment -- Background -- Mortality and poststroke depression -- Mechanism of mortality following poststroke depression -- Treatment of morbidity and mortality related to poststroke depression -- REFERENCES -- 19 Suicidal thoughts and plans -- Background -- Suicidal thoughts after acute stroke -- REFERENCES -- 20 Biological markers -- REFERENCES -- 21 Mechanisms of poststroke depression -- REFERENCES -- 22 Treatment of poststroke depression -- Background -- Pharmacological treatments -- Electroconvulsive treatment -- Transcranial magnetic stimulation therapy -- REFERENCES -- 23 Prevention of poststroke depression
- Format
- e-Book
- Location
- Online
Natriuretic Peptides : The Hormones of the Heart
https://libcat.nshealth.ca/en/permalink/provcat28235
edited by Aldo Clerico, Michele Emdin.
--Milan:
Springer-Verlag Italia
, c2006.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Clerico, Aldo
- Other Authors
- Emdin, Michele
- Responsibility
- edited by Aldo Clerico, Michele Emdin
- Place of Publication
- Milan
- Publisher
- Springer-Verlag Italia
- Date of Publication
- c2006
- ISBN
- 9788847004986
- Subjects (MeSH)
- Biological Markers
- Cardiovascular Diseases - physiopathology
- Natriuretic Peptides - analysis
- Subjects (LCSH)
- Cardiology
- Endocrinology
- Format
- e-Book
- Location
- Online
Color Atlas of Immunocytochemistry in Diagnostic Cytology
https://libcat.nshealth.ca/en/permalink/provcat30417
edited by Parvin Ganjei-Azar, Mehrdad Nadji.
--Boston, MA:
Springer Science+Business Media
, c2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Ganjei-Azar, Parvin
- Other Authors
- Nadji, Mehrdad
- Responsibility
- edited by Parvin Ganjei-Azar, Mehrdad Nadji
- Place of Publication
- Boston, MA
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2007
- ISBN
- 9780387321226
- Subjects (MeSH)
- Cytodiagnosis - Atlases
- Immunohistochemistry - methods - Atlases
- Neoplasms - diagnosis - Atlases
- Neoplasms - metabolism
- Tumor Markers, Biological
- Subjects (LCSH)
- Cytology
- Immunology
- Pathology
- Format
- e-Book
- Location
- Online
Outcome prediction in cancer
https://libcat.nshealth.ca/en/permalink/provcat27210
editor, Azzam F.G. Taktak and Anthony C. Fisher.
(1st ed.)
--Amsterdam, Netherlands:
Elsevier
, 2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Taktak, Azzam F.G
- Other Authors
- Taktak, Azzam F. G
- Fisher, Anthony C
- Responsibility
- editor, Azzam F.G. Taktak and Anthony C. Fisher
- Edition
- 1st ed.
- Place of Publication
- Amsterdam, Netherlands
- Publisher
- Elsevier
- Date of Publication
- 2007
- Physical Description
- xx, 461 p.
- ISBN
- 6610747288 (electronic bk.)
- 9786610747283 (electronic bk.)
- Subjects (MeSH)
- Neoplasms - diagnosis
- Prognosis
- Contents
- Cover -- Copyright page -- Foreword -- Contents -- Contributors -- Introduction -- Section 1: The Clinical Problem -- Chapter 1: The Predictive Value of Detailed Histological Staging of Surgical Resection Specimens in Oral Cancer -- 1. INTRODUCTION -- 2. PREDICTIVE FEATURES RELATED TO THE PRIMARY TUMOUR -- 3. PREDICTIVE FEATURES RELATED TO THE REGIONAL LYMPH NODES -- 4. DISTANT (SYSTEMIC) METASTASES -- 5. GENERAL PATIENT FEATURES -- 6. MOLECULAR AND BIOLOGICAL MARKERS -- 7. THE WAY AHEAD? -- REFERENCES -- Chapter 2: Survival after Treatment of Intraocular Melanoma -- 1. INTRODUCTION -- 2. INTRAOCULAR MELANOMA -- 3. STATISTICAL METHODS FOR PREDICTING METASTATIC DISEASE -- 4. PREDICTING METASTATIC DEATH WITH NEURAL NETWORKS -- 5. MISCELLANEOUS ERRORS -- 6. A NEURAL NETWORK FOR PREDICTING SURVIVAL IN UVEAL MELANOMA PATIENTS -- 7. CAVEATS REGARDING INTERPRETATION OF SURVIVAL STATISTICS -- 8. FURTHER STUDIES -- 9. CONCLUSIONS -- REFERENCES -- Chapter 3: Recent Developments in Relative Survival Analysis -- 1. INTRODUCTION -- 2. CAUSE-SPECIFIC SURVIVAL -- 3. INDEPENDENCE ASSUMPTION -- 4. EXPECTED SURVIVAL -- 5. RELATIVE SURVIVAL -- 6. POINT OF CURE -- 7. REGRESSION ANALYSIS -- 8. PERIOD ANALYSIS -- 9. AGE STANDARDIZATION -- 10. PARAMETRIC METHODS -- 11. MULTIPLE TUMOURS -- 12. CONCLUSION -- REFERENCES -- Section 2: Biological and Genetic Factors -- Chapter 4: Environmental and Genetic Risk Factors of Lung Cancer -- 1. INTRODUCTION -- 2. LUNG CANCER INCIDENCE AND MORTALITY -- 3. CONCLUSION -- REFERENCES -- Chapter 5: Chaos, Cancer, the Cellular Operating System and the Prediction of Survival in Head and Neck Cancer -- 1. INTRODUCTION -- 2. CANCER AND ITS CAUSATION -- 3. FUNDAMENTAL CELL BIOLOGY AND ONCOLOGY -- 4. A NEW DIRECTION FOR FUNDAMENTAL CELL BIOLOGY AND ONCOLOGY -- 5. COMPLEX SYSTEMS ANALYSIS AS APPLIED TO BIOLOGICAL SYSTEMS AND SURVIVAL ANALYSIS -- 6. METHODS OF ANALYSING FAILURE IN BIOLOGICAL SYSTEMS -- 7. A COMPARISON OF A NEURAL NETWORK WITH COX'S REGRESSION IN PREDICTING SURVIVAL IN OVER 800 PATIENTS -- 8. THE NEURAL NETWORK AND FUNDAMENTAL BIOLOGY AND ONCOLOGY -- 9. THE DIRECTION OF FUTURE WORK -- 10. SUMMARY -- REFERENCES -- Section 3: Mathematical Background of Prognostic Models -- Chapter 6: Flexible Hazard Modelling for Outcome Prediction in Cancer: Perspectives for the Use of Bioinformatics Knowledge -- 1. INTRODUCTION -- 2. FAILURE TIME DATA -- 3. PARTITION AND GROUPING OF FAILURE TIMES -- 4. COMPETING RISKS -- 5. GLMs AND FFANNs -- 6. APPLICATIONS TO CANCER DATA -- 7. CONCLUSIONS -- REFERENCES -- Chapter 7: Information Geometry for Survival Analysis and Feature Selection by Neural Networks -- 1. INTRODUCTION -- 2. SURVIVAL FUNCTIONS -- 3. STANDARD MODELS FOR SURVIVAL ANALYSIS -- 4. THE NEURAL NETWORK MODEL -- 5. LEARNING IN THE CPENN MODEL -- 6. THE BAYESIAN APPROACH TO MODELLING -- 7. VARIABLE SELECTION -- 8. THE LAYERED PROJECTION ALGORITHM -- 9. A SEARCH STRATEGY -- 10. EXPERIMENTS -- 11. CONCLUSION -- REFERENCES -- Chapter 8: Artificial Neural Networks Used in the Survival Analysis of Breast Cancer Patients: A Node-Negat
- Format
- e-Book
- Location
- Online
Cancer of the ovary
https://libcat.nshealth.ca/en/permalink/provcat27283
[edited by] Rodney Reznek.
--Cambridge, UK:
Cambridge University Press
, 2007.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Reznek, Rodney H
- Responsibility
- [edited by] Rodney Reznek
- Place of Publication
- Cambridge, UK
- Publisher
- Cambridge University Press
- Date of Publication
- 2007
- Physical Description
- 176 p.
- Series Title
- Contemporary issues in cancer imaging
- ISBN
- 6610749310
- Subjects (MeSH)
- Ovarian Neoplasms
- Contents
- Cover -- Half-title -- Series-title -- Title -- Copyright -- Contents -- Contributors -- Series Foreword -- Preface to Cancer of the Ovary -- 1 Epidemiology of Ovarian Cancer -- Introduction -- Genetic Epidemiology -- Familial Risks -- Genetic Susceptibility to Ovarian Cancer -- Low Penetrance Ovarian Cancer Susceptibility -- Reproductive and Hormonal Factors -- Early Menarche and Late Menopause -- Parity -- Lactation -- Oral Contraceptive Pill -- Infertility -- Hormone Replacement Therapy -- Other Factors -- Age -- Talcum Powder -- Pelvic Surgery -- Endometriosis -- Polycystic Ovarian Syndrome (PCOS) -- Pelvic Inflammatory Disease (PID) -- Diet -- Conclusion -- REFERENCES -- 2 The Pathological Features of Ovarian Neoplasia -- Introduction -- Non-Neoplastic Cysts -- Ovarian Neoplasms -- Benign Epithelial and Mixed Ovarian Tumours -- Serous Cystadenoma -- Mucinous Cystadenoma -- Endometrioid Cystadenoma -- Brenner Tumour -- Borderline Epithelial Ovarian Tumours -- Borderline Serous Ovarian Neoplasia -- Borderline Mucinous Ovarian Neoplasia -- Borderline Endometrioid Ovarian Neoplasia -- Borderline Ovarian Brenner Tumour -- Invasive Epithelial Ovarian Tumours -- Serous Ovarian Carcinoma -- Mucinous Ovarian Carcinoma -- Endometrioid Ovarian Carcinoma -- Malignant Brenner and Transitional Cell Ovarian Carcinoma -- Germ Cell Tumours of the Ovary -- Dysgerminoma -- Yolk Sac Tumour -- Sex Cord and Stromal Tumours of the Ovary -- Granulosa Cell Tumours -- Thecoma and Fibroma -- Sertoli-Leydig Cell Tumours -- Staging of Ovarian Neoplasms -- Tumours Metastatic to the Ovary -- Conclusion -- REFERENCES -- 3 Ovarian Cancer Screening -- Introduction -- Screening Test Requirements -- Screening Techniques -- Vaginal Examination -- Tumour Markers -- Ultrasound -- Other Modalities -- Multimodal Screening -- Test Acceptability -- Target Populations -- The 'High-Risk' Population -- The General Population -- The Cost of Screening -- Conclusions -- Acknowledgement -- REFERENCES -- 4 Surgical Management of Patients with Epithelial Ovarian Cancer -- Introduction -- Staging Laparotomy -- Primary Cytoreductive Surgery -- Delayed Primary Surgery following Neoadjuvant Chemotherapy -- Interval Debulking following Induction Chemotherapy -- Cytoreductive Surgery for Recurrent Ovarian Cancer -- Palliative Surgery for Recurrent Ovarian Cancer -- Conclusion -- REFERENCES -- 5 Medical Treatment of Ovarian Carcinoma -- Introduction -- Chemotherapy in Early Stage Disease -- Chemotherapy in Advanced Disease -- Systemic Chemotherapy -- Other Treatment Approaches -- Relapsed Ovarian Cancer -- Chemotherapy -- Other Platinum Agents -- Combination versus Single-Agent Therapy -- Response Prediction -- When should Treatment be Started? -- Other Treatment Approaches -- Endocrine Therapies -- Conclusion -- REFERENCES -- 6 Ultrasound in Ovarian Carcinoma -- Ultrasonic Technique -- Morphological Assessment -- Doppler Examination -- New Developments -- Ultrasonic Diagnosis of Malignancy -- Malignant Features -- Ultrasonic Features of Primary Malignancies -- Differential Diagnosis of Adnexal Masses -- Simple Ovarian Cysts --T$74
- Format
- e-Book
- Location
- Online
Principles of Molecular Oncology
https://libcat.nshealth.ca/en/permalink/provcat30037
edited by Miguel H. Bronchud, Mary Ann Foote, Giuseppe Giaccone, Olufunmilayo Olopade, Paul Workman.
(3rd ed.)
--Totowa, NJ:
Humana Press
, c2008.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Bronchud, Miguel H
- Other Authors
- Foote, Mary Ann
- Giaccone, Giuseppe
- Olopade, Olufunmilayo
- Workman, Paul
- Responsibility
- edited by Miguel H. Bronchud, Mary Ann Foote, Giuseppe Giaccone, Olufunmilayo Olopade, Paul Workman
- Edition
- 3rd ed.
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- c2008
- ISBN
- 9781597454704
- Subjects (LCSH)
- Oncology
- Hematology
- Format
- e-Book
- Location
- Online
Improving the quality of cancer clinical trials : workshop summary
https://libcat.nshealth.ca/en/permalink/provcat27146
Institute of Medicine.
--Washington, DC:
National Academies Press
, 2008.
- Available Online
- View e-Book
- Access
- Open access: download free PDF
- Location
- Online
- Available Online
- View e-Book
- Corporate Author
- Institute of Medicine
- Place of Publication
- Washington, DC
- Publisher
- National Academies Press
- Date of Publication
- 2008
- ISBN
- 9780309116688
- Subjects (MeSH)
- Clinical Trials as Topic
- Neoplasms - drug therapy
- Contents
- New clinical trial designs. Phase 0 trials -- Adaptive trial designs -- Targeting multiple pathways with multiple drugs -- Preclinical model systems -- Molecular imaging. Current and developing methods -- Challenges of molecular imaging -- Screening for predictive markers. The challenges of clinical validation -- Bioimaging predictive markers -- Clinical translation -- Panel discussion -- Costs of clinical trials. Regulatory costs -- Patient accrual -- Global outsourcing -- Time is money -- Public-private collaborations -- Regulatory issues. Regulatory barriers to innovation -- Patient advocacy perspective -- Regulation of in vitro diagnostics -- Regulatory issues in improving cancer clinical trials -- Reports from the case study discussion groups. Adaptive trial design -- Phase 0 trials -- Imaging -- Use of proteomics/genomics to assign therapy in lung cancer -- Use of genetics/genomics to assign therapy -- Concluding remarks.
- Access
- Open access: download free PDF
- Format
- e-Book
- Location
- Online
Breast Carcinoma
https://libcat.nshealth.ca/en/permalink/provcat40623
edited by M. A. Hayat.
--Dordrecht:
Springer
, c2008.
- Available Online
- View e-Book
- Location
- Online
This is the first book that discusses subjects of diagnosis, therapy, therapy assessment, and prognosis of breast cancer in one single volume. Cancer killed 6.7 million people around the world in 2002 and this figure is expected to rise to 10.1 million in 2020. Approximately 189,510 new cases of breast cancer were reported in 2007 in the United States, and 40,910 died in the same year. Focusing on Breast Carcinoma, this first volume in the series Methods of Cancer Diagnosis, Therapy and Prognos…
- Available Online
- View e-Book
- Other Authors
- Hayat, M. A
- Responsibility
- edited by M. A. Hayat
- Alternate Title
- Methods of cancer diagnosis, therapy, and prognosis
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2008
- Physical Description
- 1 online resource (xlvii, 727 p. : ill.)
- Series Vol.
- v. 1
- Series Title
- Methods of cancer diagnosis, therapy, and prognosis
- ISBN
- 9781402083693
- 9781402083686 (print ed.)
- Subjects (MeSH)
- Breast Neoplasms
- Abstract
- This is the first book that discusses subjects of diagnosis, therapy, therapy assessment, and prognosis of breast cancer in one single volume. Cancer killed 6.7 million people around the world in 2002 and this figure is expected to rise to 10.1 million in 2020. Approximately 189,510 new cases of breast cancer were reported in 2007 in the United States, and 40,910 died in the same year. Focusing on Breast Carcinoma, this first volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis brings together 56 leading scientists from around the world to deliver a comprehensive treatise on all aspects of breast cancer, including diagnosis, treatments and prognosis. Scientists and clinicians have contributed state of the art chapters on their respective areas of expertise providing the reader a whole field view of breast cancer management. This fully illustrated volume: Presents a constructive evaluation of commonly used methods for elucidating primary and secondary cancer initiation, progression, relapse, and metastasis; Highlights methods of breast cancer diagnosis and treatment assessment including various imaging modalities such as ultrasound, computed tomography, magnetic resonance imaging, immunohistochemistry and histochemistry; Discusses detailed therapeutic protocols, including both their benefits and side-effects; Discusses examples of breast cancer treatments includingchemotherapy, radiation, chemoradiation, surgery, hormonal - and immunotherapy; Details the molecular processes that lead to the development and proliferation of cancer cells; Includes recent major advances in cancer diagnosis and therapy assessment. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.
- Contents
- Breast Cancer: An Introduction -- Breast Cancer: Computer-Aided Detection -- Sebaceous Carcinoma of the Breast: Clinicopathologic Features -- Breast Cancer: Detection by In-Vivo Imaging of Angiogenesis -- Breast and Prostate Biopsies: Use of Optimized High-Throughput MicroRNA Expression for Diagnosis (Methodology) -- Familial Breast Cancer: Detection of Prevalent High-Risk Epithelial Lesions -- Differentiation Between Benign and Malignant Papillary Lesions of Breast: Excisional Biopsy or Stereotactic Vacuum-Assisted Biopsy (Methodology) -- Multicentric Breast Cancer: Sentinel Node Biopsy as a Diagnostic Tool -- Breast Cancer Recurrence: Role of Serum Tumor Markers CEA and CA 15-3 -- Breast Cancer Patients Before, During or After Treatment: Circulating Tumor Cells in Peripheral Blood Detected by Multigene Real-Time Reverse Transcriptase-Polymerase Chain Reaction -- Breast Cancer Patients: Diagnostic Epigenetic Markers in Blood -- Breast Cancer Patients: Detection of Circulating Cancer Cell-Related mRNA Markers with Membrane Array Method -- Prediction of Metastasis and Recurrence of Breast Carcinoma: Detection of Survivin-Expressing Circulating Cancer Cells -- Node-Negative Breast Cancer: Predictive and Prognostic Value of Peripheral Blood Cytokeratin-19 mRNA-Positive Cells -- Breast and Colon Carcinomas: Detection with Plasma CRIPTO-1 -- Breast Cancer Risk in Women with Abnormal Cytology in Nipple Aspirate Fluid -- Tissue Microarrays: Construction and Utilization for Biomarker Studies -- Systematic Validation of Breast Cancer Biomarkers Using Tissue Microarrays: From Construction to Image Analysis -- Phyllodes Tumors of the Breast: The Role of Immunohistochemistry in Diagnosis -- Phyllodes Tumor of the Breast: Prognostic Assessment Using Immunohistochemistry -- Metaplastic Breast Carcinoma: Detection Using Histology and Immunohistochemistry -- Invasive Breast Cancer: Overexpression of HER-2 Determined by Immunohistochemistry and Multiplex Ligation-Dependent Probe Amplification -- Operable Breast Cancer: Neoadjuvant Treatment (Methodology) -- Chemotherapy for Breast Cancer -- Locally Advanced Breast Cancer: Role of Chemotherapy in Improving Prognosis -- Relevance of Dose-Intensity for Adjuvant Treatment of Breast Cancer -- Advanced Breast Cancer: Treatment with Docetaxel/Epirubicin -- Systemic Therapy for Breast Cancer: Using Toxicity Data to Inform Decisions -- Chemotherapy for Metastatic Breast Cancer Patients Who Received Adjuvant Anthracyclines (An Overview) -- Estrogen Receptor-Negative and HER-2/neu-Positive Locally Advanced Breast Carcinoma: Therapy with Paclitaxel and Granulocyte-Colony Stimulating Factor -- Breast Cancer: Side Effects of Tamoxifen and Anastrozole -- Breast Cancer: Expression of HER-2 and Epidermal Growth Factor Receptor as Clinical Markers for Response to Targeted Therapy -- Young Breast Cancer Patients Undergoing Breast-Conserving Therapy: Role of BRCA1 and BRCA2 -- Radiation Therapy for Older Women with Early Breast Cancer -- Acute Side Effects of Radiotherapy in Breast Cancer Patients: Role of DNA-Repair and Cell Cycle Control Genes -- 18F-Fluorodeoxyglucose/Positron Emission Tomography in Primary Breast Cancer: Factors Responsible for False-Negative Results -- Sentinel Lymph Node Surgery During Prophylactic Mastectomy (Methodology) -- Breast Conservation Surgery: Methods -- Lymph Node-Negative Breast Carcinoma: Assessment of HER-2/neu Gene Status as Prognostic Value -- Multifocal or Multicentric Breast Cancer: Understanding Its Impact on Management and Treatment Outcomes -- Are Breast Cancer Survivors at Risk for Developing Other Cancers? -- Distant Metastasis in Elderly Patients with Breast Cancer: Prognosis with Nodal Status -- Concomitant Use of Tamoxifen with Radiotherapy Enhances Subcutaneous Breast Fibrosis in Hypersensitive Patients -- Malignant Phyllodes Tumor of the Breast: Is Adjuvant Radiotherapy Necessary? -- Locally Advanced Breast Cancer: Multidrug Resistance -- Breast Cancer: Diagnosis of Recurrence Using 18 F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography -- Role of Sentinel Lymph Node Biopsy in Ductal Carcinoma In Situ: Diagnosis and Methodology -- Breast Conservation Treatment of Early Stage Breast Carcinoma: Risk of Cardiac Mortality.
- Format
- e-Book
- Location
- Online
Pathogenesis and Clinical Practice in Gastroenterology
https://libcat.nshealth.ca/en/permalink/provcat40625
edited by I. Ferkolj, A. Gangl, P. R. Galle, B. Vucelic.
--Dordrecht:
Springer
, c2008.
- Available Online
- View e-Book
- Location
- Online
The translation of new molecular understanding of disease into clinical practice in gastroenterology is a special challenge. The Falk Symposium No. 160, entitled "Pathogenesis and Clinical Practice in Gastroenterology", held 15-16 June 2007 in Portorož, Slovenia, provided a stimulating framework to bridge discussions from bench to bedside. The proceedings of the symposium are contained in this book, and the unifying theme is the growing understanding of inflammation as a driving force in chroni…
- Available Online
- View e-Book
- Other Authors
- Ferkolj, I
- Gangl, A
- Galle, P. R
- Vucelic, B
- Other Authors
- Falk Symposium (160th : 2007 : Portorož, Slovenia)
- Responsibility
- edited by I. Ferkolj, A. Gangl, P. R. Galle, B. Vucelic
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2008
- Physical Description
- 1 online resource (xv, 280 p. : ill.)
- Series Vol.
- 160
- Series Title
- Falk Symposium
- ISBN
- 9781402087677
- 9781402087660 (print ed.)
- Abstract
- The translation of new molecular understanding of disease into clinical practice in gastroenterology is a special challenge. The Falk Symposium No. 160, entitled "Pathogenesis and Clinical Practice in Gastroenterology", held 15-16 June 2007 in Portorož, Slovenia, provided a stimulating framework to bridge discussions from bench to bedside. The proceedings of the symposium are contained in this book, and the unifying theme is the growing understanding of inflammation as a driving force in chronic disease leading to disability and malignancy. Aspects of early detection--endoscopically or via molecular markers--are covered as well as in-depth discussions of the validation of new findings in clinical practice. Whilst on a molecular basis gastroenterologists and hepatologists try to shed light on the same intracellular pathways, clinical implications such as surveillance of cancer in IBD or chronic hepatitis with cirrhosis have to be tailored to specific needs. New therapeutic agents--approved or on the horizon of early clinical studies--will dramatically change the options of patients with chronic disease such as Crohn's disease, viral hepatitis or hepatocellular carcinoma.
- Contents
- Section I. Dysphagia and reflux -- Physiology of swallowing and antireflux mechanisms: anything new from a radiologist's view? -- Oropharyngeal dysphagia, achalasia, and other oesophageal motility problems: clinical relevance and management -- Outcomes of different treatment opproaches for gastro-oesophageal reflux disease -- Barrett's oesophagus: screening, surveillance, treatment: are all questions answered? -- Section II. Helicobacter pylori, NSAID, gastric cancer -- Helicobacter pylori infection: diagnosis, treatment and risks of untreated infection -- Section III. Inflammatory bowel disease section -- Genetics, immunology and biomarkers in clinical practice: do they assist in clinical management? -- Standard therapy for ulcerative colitis and Crohn's disease: the ECCO guidelines -- Biologics, novel therapeutic alternatives in inflammatory bowel disease -- Section IV. Lower gastrointestinal tract (coeliac disease, infection and malignancy) -- Recent advances in coeliac disease -- Gastrointestinal manlfestations of AIDS -- Prevention and screening for colorectal cancer -- Lymphomas of the gastrointestinal tract -- Section V. Clinical challenges in liver diseases -- Do we still need liver biopsies? -- Inflammation and human cancer -- Section VI. Viral hepatitis -- New insights in the immunology of viral hepatitis B and C -- New aspects of treatment of chronic hepatitis C -- Section VII. Metabolic and autoimmune liver injury -- Non-alcoholic steatohepatitis: metabolic syndrome of the liver -- Autoimmune hepatitis -- Immunology of primary biliary cirrhosis and primary sclerosing cholangitis -- Alcoholic hepatitis -- Section VIII. Complications of cirrhosis -- Hepatorenal syndrome in cirrhosis -- Variceal bleeding -- Surveillance and prevention of hepatocellular carcinoma -- Algorithms of diagnosis and options of hepatocellular carcinoma therapy -- Surgical therapy of liver cancer: resection and transplantation.
- Format
- e-Book
- Publication Type
- Congress
- Location
- Online
Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer : New Molecular Aspects and their Potential as Targets
https://libcat.nshealth.ca/en/permalink/provcat28069
edited by Stephen Hiscox, Julia Gee, Robert I. Nicholson.
--[Dordrecht]:
Springer Netherlands
, c2009.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Hiscox, Stephen
- Other Authors
- Gee, Julia
- Nicholson, Robert I
- Responsibility
- edited by Stephen Hiscox, Julia Gee, Robert I. Nicholson
- Place of Publication
- [Dordrecht]
- Publisher
- Springer Netherlands
- Date of Publication
- c2009
- ISBN
- 9781402085260
- Subjects (MeSH)
- Breast Neoplasms
- Drug Resistance, Neoplasm
- Tumor Markers, Biological
- Subjects (LCSH)
- Oncology
- Gynecology
- Endocrinology
- Pharmacy
- Format
- e-Book
- Location
- Online
Liver Cancer
https://libcat.nshealth.ca/en/permalink/provcat40941
edited by M. A. Hayat.
--Dordrecht:
Springer
, c2009.
- Available Online
- View e-Book
- Location
- Online
This fifth volume of the series, Methods of Cancer Diagnosis, Therapy, and Prognosis, discusses in detail the diagnosis, treatment, and prognosis of liver cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume is divided into 7 sections: Applications of Imaging, Resectable Liver Cancer, Unresectable Liver Cancer, Hepatocellular Cancer, Liver Colorectal Metastasis, Biliary Cancer, and Spl…
- Available Online
- View e-Book
- Other Authors
- Hayat, M. A
- Responsibility
- edited by M. A. Hayat
- Alternate Title
- Methods of cancer diagnosis, therapy, and prognosis
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2009
- Physical Description
- 1 online resource (xliv, 514 p. : illus.)
- Series Vol.
- v. 5
- Series Title
- Methods of cancer diagnosis, therapy, and prognosis
- ISBN
- 9781402098048
- 9781402098031 (print ed.)
- Subjects (MeSH)
- Liver Neoplasms - diagnosis
- Liver Neoplasms - therapy
- Neoplasm Metastasis
- Abstract
- This fifth volume of the series, Methods of Cancer Diagnosis, Therapy, and Prognosis, discusses in detail the diagnosis, treatment, and prognosis of liver cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume is divided into 7 sections: Applications of Imaging, Resectable Liver Cancer, Unresectable Liver Cancer, Hepatocellular Cancer, Liver Colorectal Metastasis, Biliary Cancer, and Splenic Cancer. The book discusses imaging modalities for diagnosis, treatment assessment, and prognosis. Includes descriptions of radial magnetic resonance imaging, helical computed tomography, magnetic resonance imaging, FDG-PET, contrast-enhanced sonography, multidetector-row computed tomography, and single photon emission computed tomography. Presents imaging methods for localized fibrous tumors of the liver, abdominal neoplasms, cholangiocarcinoma, gall bladder carcinoma, hepatic cellular carcinoma, extrahepatic disease, intrahepatic disease, focal liver lesions, biliary cystic tumors, extra hepatic bile duct carcinoma, and splenic metastases. Highlights methods for treatment of hepatocellular carcinoma (HCC) with thalidomide and transarterial treatment of hepatic malignancies. Discusses postoperative interferon alpha treatment of patients with HCC. Details the methods of immunohistochemistry, tissue microarray, and proteomic analysis for diagnosis and prognosis. The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. The field of oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of liver cancer and other cancer types. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.
- Contents
- Liver Cancer -- Applications of Positron Emission Tomography in Liver Imaging: An Overview -- Localized Fibrous Tumor of the Liver: Imaging Features -- A Radial Magnetic Resonance Imaging Method for Imaging Abdominal Neoplasms -- Liver: Helical Computed Tomography and Magnetic Resonance Imaging -- Resectable Liver Cancer -- Selection of Patients for Resection of Hepatic Colorectal Metastases: 18F-Fluorodeoxyglucose/Positron Emission Tomography -- Ultrasonography During Liver Surgery -- Unresectable Liver Cancer -- Intraoperative Magnetic Resonance Imaging for Radiofrequency Ablation of Hepatic Tumors -- Surgically Unresectable and Chemotherapy-Refractory Metastatic Liver Carcinoma: Treatment with Yttrium-90 Microsphere Followed by Assessment with Positron Emission Tomography -- Unresectable Liver Metastases from Colorectal Cancer: Methodology and Prognosis with Radiofrequency Ablation -- Hepatocellular Carcinoma -- Screening with Ultrasonography of Patients at High-Risk for Hepatocellular Carcinoma: Thrombocytopenia as a Valid Surrogate of Cirrhosis -- Hepatocellular Carcinoma: Contrast-Enhanced Sonography -- Focal Liver Lesion: Nonlinear Contrast-Enhanced Ultrasound Imaging -- Hepatocellular Carcinoma: Magnetic Resonance Imaging -- Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma: Correlation with Radiologic Findings -- Detection of Small Hepatic Lesions: Superparamagnetic Oxide-Enhanced Diffusion-Weighted T2 FSE Imaging -- Diagnosis of Hepatocellular Carcinoma: Multidetector-Row Computed Tomography and Magnetic Resonance Imaging -- Hepatocellular Carcinoma: Effect of Injection Rate/Injection Duration of Contrast Material on Computed Tomography -- Detection of Combined Hepatocellular and Cholangiocarcinomas: Enhanced Computed Tomography -- Hepatocellular Carcinoma and Adenomatous Hyperplasia (Dysplastic Nodules): Dynamic Computed Tomography and a Combination of Computed Tomography and Angiography -- Hepatocellular Cancer in Cirrhotic Patients: Radiological Imaging -- Treatment of Hepatocellular Carcinoma with Thalidomide: Assessment with Power Doppler Ultrasound -- Perfusion Scintigraphy with Integrated Single Photon Emission Computed Tomography/Computed Tomography in the Management of Transarterial Treatment of Hepatic Malignancies -- Postoperative Interferon Alpha Treatment of Patients with Hepatocellular Carcinoma: Expression of p48 Using Tissue Microarray -- Hepatocellular Carcinoma: Overexpression of Homeoprotein Six 1 as a Marker for Predicting Survival -- Hepatocellular Carcinoma: KiSS-1 Overexpression as a Prognostic Factor -- Hepatocellular Carcinoma: Prognosis Using Hepatoma-Derived Growth Factor Immunohistochemistry -- Hepatitis C Virus-Related Human Hepatocellular Carcinoma: Predictive Markers Using Proteomic Analysis (Methodology) -- Metastases -- Liver Metastases from Colorectal Cancer: Ultrasound Imaging -- Preclinical Liver Metastases: Three-Dimensional High-Frequency Ultrasound Imaging -- Colorectal Liver Metastases: 18F-Fluorodeoxyglucose-Positron Emission Tomography -- Biliary Cancer -- Biliary Cystic Tumors: Clinicopathological Features -- Cholangiocarcinoma: Intraductal Sonography -- Extrahepatic Bile Duct Carcinoma: Role of the p53 Protein Family -- Extrahepatic Bile Duct Carcinoma: Mucin 4, a Poor Prognostic Factor -- Hilar Cholangiocarcinoma: Photodynamic Therapy and Stenting -- Splenic Cancer -- Splenic Metastases: Diagnostic Methods.
- Format
- e-Book
- Location
- Online
Manual of pediatric hematology and oncology
https://libcat.nshealth.ca/en/permalink/provcat31570
Philip Lanzkowsky.
(5th ed.)
--London:
Academic
, 2010.
- Available Online
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- Access
- Registration required for PDF access.
- Location
- Online
This will be the fifth edition of successful clinical manual aimed at all practitioners treating children with cancer and blood diseases, such as leukemia, anemia, and bone marrow failure. As with previous editions, this edition will be a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients even if they have not had exte…
- Available Online
- View e-Book
- Author
- Lanzkowsky, Philip
- Responsibility
- Philip Lanzkowsky
- Edition
- 5th ed.
- Place of Publication
- London
- Publisher
- Academic
- Date of Publication
- 2010
- Physical Description
- 1 online resource
- ISBN
- 9780123751546 (electronic bk.)
- Subjects (MeSH)
- Pediatrics
- Hematology
- Subjects (LCSH)
- Hematologic Diseases
- Child
- Infant
- Neoplasms
- Pediatric hematology
- Tumors in children
- Abstract
- This will be the fifth edition of successful clinical manual aimed at all practitioners treating children with cancer and blood diseases, such as leukemia, anemia, and bone marrow failure. As with previous editions, this edition will be a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients even if they have not had extensive previous hematologic or oncologic experience. It will contain a list of normal values at various ages in children, which is extremely useful as a reference in the management of patients. Since the previous edition was written five years ago, there have been considerable advances particularly in the treatment and management of oncologic diseases in children. These oncology sections (approximately 40% of the book) will be entirely rewritten to incorporate all current protocols. In addition, advances in many other areas will require that all hematology sections of the book be updated. The successful basic format and content of clinical manifestations, diagnosis and differential diagnosis will be maintained - as in previous editions, the editor will closely edit chapter content to maintain consistency in format, depth, and style. In addition to the core group of hematologists and oncologists from Schneider Children's Hospital, who contributed to the 4th edition, the editor is inviting 15 new authors who are all experts from around the country - in order to keep up with the advances in management of hem/onc diseases. The book will reflect the 45+ years of practical experience by the editor as well as the extensive clinical experience and research expertise of the various contributors. Feature Offers a concise, systematic approach to all pediatric hematologic and oncologic disorders in one reference manual Easy-to-read format: multiple tables, charts, and flow-diagrams for diagnosis and management of pediatric hematologic and oncologic disorders Clear presentation by practicing clinicians, who are also academic researchers, of recent developments in molecular genetics, cytogenetics, immunology, transplantation, and biochemistry to the extent that they have bearing on clinical practice Benefits Practitioners responsible for the care of children with hem/onc diseases will save time going to one concise, authoritative source for diagnosis and treatment options, without having to wade through all the details in larger tomes on hematology or oncology, or in thousands of journal articles Residents will use it as a guide to prepare for board examinations in pediatric hematology/oncology, pediatrics, hematology, and oncology Practicing pediatricians, hematologists, oncologists, fellows, and pediatric nurses will use it a quick source for a second opinion in diagnosis and disease management when they are unable to consult with a pediatric hem/onc specialist Practicing pediatric hem/onc specialists will use the book as a "refresher course" and will appreciate the systematic approach For all practitioners, correct diagnosis (and therefore correct treatment) of oncologic and hematologic diseases depends on a strong understanding of the molecular basis for the disease
- Contents
- Classification and Diagnosis of Anemia During Childhood -- Anemia During the Neonatal Period -- Iron-Deficiency Anemia -- Megaloblastic Anemia -- Hematologic Manifestations of Systemic Illness -- Bone Marrow Failure -- Hemolytic Anemia Due to Membrane and Enzyme Defects -- Hemoglobinopathies -- Extracorpuscular Hemolytic Disease -- Polycythemia -- Disorders of the White Blood Cells -- Disorders of Platelets -- Hemostatic Disorders -- Thrombotic Disorders -- Lymphadenopathy and Splenomegaly -- Lymphoproliferative Disorders, Myelodysplastic Syndromes and Myeloproliferative Disorders -- Leukemias -- Histiocytosis Syndromes -- Hodgkin's Disease -- Non-Hodgkin's Lymphoma -- Central Nervous System Malignancies -- Neuroblastoma -- Wilms Tumor -- Rhabdomyosarcoma and other Soft Tissue Sarcomas -- Malignant Bone Tumors -- Retinoblastoma -- Germ Cell Tumors -- Hepatic Tumors -- Hematopoietic Stem Cell Transplantation -- Management of Oncologic Emergencies -- Supportive Care of Patients with Cancer -- Evaluation, Investigations and Management of Late Effects of Childhood Cancer -- Psychosocial Aspects of Cancer for Children and their Families -- Appendix 1. Hematologic Reference Values -- Appendix 2. Biological Tumor Markers -- Appendix 3. Pharmacologic Properties of the Commonly Used Anticancer Drugs
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- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Atlas of diagnostic oncology
https://libcat.nshealth.ca/en/permalink/provcat31974
Dana-Farber Cancer Institute ; edited by Arthur T. Skarin ; associate editors, Kitt Schaffer, Tad Wieczorek, Janina Longtine.
(4th ed.)
--Philadelphia, PA:
Mosby Elsevier
, c2010.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
- Available Online
- View e-Book
- Corporate Author
- Dana-Farber Cancer Institute
- Other Authors
- Skarin, Arthur T
- Responsibility
- Dana-Farber Cancer Institute ; edited by Arthur T. Skarin ; associate editors, Kitt Schaffer, Tad Wieczorek, Janina Longtine
- Edition
- 4th ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Mosby Elsevier
- Date of Publication
- c2010
- Physical Description
- 1 online resource (xix, 755 p.)
- ISBN
- 9780323059053
- Subjects (MeSH)
- Neoplasms - diagnosis - Atlases
- Subjects (LCSH)
- Cancer - Atlases
- Neoplasms - diagnosis - Atlases
- Contents
- The role of molecular probes and other markers in the diagnosis of malignancy / Tad Wieczorek and Janina A. Longtine -- Radiographic evaluation of cancer / Kitt Shaffer and Annick Van Den Abbeele -- Nuclear oncology / Annick van den Abbeele and Steven Burrell -- Cancer of the head and neck region / Robert Haddad and Marshall Posner -- Lung cancer and tumors of the heart and mediastinum / Ravi Salgia and Arthur T. Skarin -- Malignant mesothelioma / Pasi Janne -- Cancer of the gastrointestinal tract and neuroendocrine tumors / Jeffrey Meyerhardt and Matthew Kulke -- Cancer of the genitourinary tract / William K. Oh and Robert Ross -- Gynecologic tumors and malignancies / Ursula Matulonis and David R. Genest -- Breast cancer / Susana M. Campos and Wendy Chen -- Endocrine tumors and malignancies / Francis D. Moore -- Sarcomas of soft tissue and bone and gist / Susan George and George D. Demetri -- Skin cancer / Philip Friedlander and F. Stephen Hodi -- Neoplasms of the central nervous system / Elizabeth A. Maher -- Acute and chronic leukemias / Martha Wadleigh and David D. Dorfman -- Hodgkin's disease and non-hodgkin lymphomas / Eric Jacobsen and David M. Dorfman -- Multiple myeloma and plasma cell dyscrasias / Kenneth C. Anderson and David M. Dorfman -- Solid tumors in childhood / Holcomb E. Grier, Antonio Perez-Atayde, Fredic A. Hoffer -- AIDS-associated malignancies / David T. Scadden -- Hereditary cancers / Judy Garber and Ken Offit -- Complications of cancer / New author and Tad Wieczorek -- Systemic and mucocutaneous reactions to chemotherapy / Joseph P. Eder and Arthur T. Skarin.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Cancer of the Testis
https://libcat.nshealth.ca/en/permalink/provcat28464
M. Pilar Laguna, Peter Albers, Carsten Bokemeyer, Jerome P. Richie, editors.
--London:
Springer
, c2010.
- Available Online
- View e-Book
- Location
- Online
Cancer of the Testis presents a thorough account of every aspect of this disease, including histology, risk factors, prognosis, clinical presentation, diagnosis and treatment. Additionally, there is a focus on the pertinent issues of fertility, late effects of primary therapy, follow-up after primary treatment and testicular cancer in childhood. With an international authorship comprised of many of the key contributors to the field, this book brings together a rich and balanced range of perspec…
- Available Online
- View e-Book
- Author
- Laguna, M. Pilar
- Other Authors
- Albers, Peter
- Bokemeyer, Carsten
- Richie, Jerome P
- Responsibility
- M. Pilar Laguna, Peter Albers, Carsten Bokemeyer, Jerome P. Richie, editors
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2010
- Physical Description
- 1 online resource (xv, 347 p. : ill.)
- ISBN
- 9781848003705
- 9781848003699 (print ed.)
- Subjects (MeSH)
- Testicular Neoplasms
- Abstract
- Cancer of the Testis presents a thorough account of every aspect of this disease, including histology, risk factors, prognosis, clinical presentation, diagnosis and treatment. Additionally, there is a focus on the pertinent issues of fertility, late effects of primary therapy, follow-up after primary treatment and testicular cancer in childhood. With an international authorship comprised of many of the key contributors to the field, this book brings together a rich and balanced range of perspectives. A state-of-the-art reference volume on testicular cancer, this book is essential reading for urologists, medical oncologists and radio-oncologists.
- Contents
- Part I. Classification and Risk Factors -- 1. Histological Classification and Pathology of Testicular Tumors -- 2. Risk Factors and Genetical Characterization -- Part II. Diagnostic and Staging of Testicular Germ Cell Tumors -- 3. Testicular Tumor Markers -- 4. Radiographic Diagnosis and Staging -- 5. Staging and Prognostic Systems -- 6. CIS and Bilateral Cancer: Clinical Presentation and Diagnostics -- Part III. Primary Surgery -- 7. Radical Orchiectomy and Testis Sparing Procedures for the Management of Germ Cell Tumors -- 8. Diagnostic and Therapeutic Laparoscopic Retroperitoneal Lymph Node Dissection in Low Stages Nonseminomatous GCC: The American View -- 9. Diagnostic and Therapeutic Laparoscopic Retroperitoneal Lymph Node Dissection in Low-Stage Nonseminomatous GCC: The European View -- Part IV A. Treatment of Stage I -- 10. Treatment of Nonseminoma: Stage I -- 11. Treatment: Seminoma: Stage I -- Part IV B. Treatment of Advanced Stages -- 12. Treatment of Patients with Stage II A/B and Advanced Nonseminomatous Germ Cell Tumors -- 13. Stage II Seminoma and Advanced Disease -- 14. Treatment of Relapse -- 15. Postchemotherapy Retroperitoneal Lymph Node Dissection -- 16. Surgical Resection at Other Sites -- 17. Extra-Gonadal Germ Cell Tumors - 18. New Systemic Therapies for Refractory Tumors -- 19. Management of Late Relapse -- Part V. Late Effects and Follow-Up -- 20. Testicular Cancer: Late Effects of Treatment -- 21. Fertility Issues -- 22. Follow-Up After Primary Treatment -- Part VI. Testicular Cancer in Childhood and Non-Germ Cell Tumors -- 23. Testicular Cancer in Childhood -- 24. Primary Non-Germ Cell Tumors of the Testis.
- Format
- e-Book
- Location
- Online
Asymptomatic Atherosclerosis : Pathophysiology, Detection and Treatment
https://libcat.nshealth.ca/en/permalink/provcat28741
edited by Morteza Naghavi.
--New York, NY:
Humana Press
, c2010.
- Available Online
- View e-Book
- Location
- Online
Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment, Dr. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication …
- Available Online
- View e-Book
- Author
- Naghavi, Morteza
- Responsibility
- edited by Morteza Naghavi
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2010
- Physical Description
- 1 online resource (xxii, 737 p. : ill.)
- Series Title
- Contemporary cardiology (Totowa, N.J. : Unnumbered)
- ISBN
- 9781603271790
- 9781603271783 (print ed.)
- Subjects (MeSH)
- Atherosclerosis - diagnosis
- Atherosclerosis - physiopathology
- Atherosclerosis - therapy
- Plaque, Atherosclerotic
- Subjects (LCSH)
- Cardiology
- Abstract
- Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment, Dr. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication (SHAPE) present a new paradigm for the screening and primary prevention of asymptomatic atherosclerosis. The text focuses on accurate, yet underutilized, measures of subclinical atherosclerosis, notably coronary artery calcium scanning and carotid intima-media thickness measurement. The authors introduce a comprehensive approach to identifying the vulnerable patients (asymptomatic individuals at risk of a near future adverse event). Additional chapters discuss future directions towards containing the epidemic of atherosclerotic cardiovascular disease using innovative solutions such as preemptive interventional therapies (bioabsorbable stents) for stabilization of vulnerable atherosclerotic plaques, mass unconditional Polypill therapy for population-based risk reduction, and ultimately vaccination strategies to prevent the development of atherosclerosis. Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and Treatment is a must-have for any cardiologist or primary care physician who wishes to practice modern preventive cardiology and manage the increasing number of asymptomatic atherosclerotic patients. Outlines more accurate measures of risk (coronary artery calcium and carotid intima-media thickness) than traditional risk factors (total cholesterol, LDL cholesterol, HDL cholesterol). Presents new multipronged strategies to aid in the early detection and treatment of high risk asymptomatic patients.
- Contents
- 1. Preventive Cardiology: The SHAPE of the Future -- 2. From Vulnerable Plaque to Vulnerable Patient -- 3. Pathology of Vulnerability Caused by High-Risk (Vulnerable) Arteries and Plaques -- 4. Pathophysiology of Vulnerability Caused by Thrombogenic (Vulnerable) Blood -- 5. Vulnerability Caused by Arrhythmogenic Vulnerable Myocardium -- 6. Approach to Atherosclerosis as a Disease: Primary Prevention Based on the Detection and Treatment of Asymptomatic Atherosclerosis -- Section I. Risk Factors and Circulating Markers of Asymptomatic Atherosclerotic Cardiovascular Disease -- 7. History of the Evolution of Cardiovascular Risk Factors and the Predictive Value of Traditional Risk-Factor-Based Risk -- 8. Comprehensive Lipid Profiling Beyond LDL -- 9. New Blood Biomarkers of Inflammation and Atherosclerosis -- 10. Genomics and Proteomics: The Role of Contemporary Biomolecular Analysis in Advancing the Knowledge of Atherosclerotic Coronary Artery Disease -- 11. Circulating Endothelial Progenitor Cells: Mechanisms and Measurements -- 12. Family History: An Index of Genetic and Environmental Predisposition to Coronary Artery Disease -- 13. Endothelial Activation Markers in Sub-clinical Atherosclerosis: Insights from Mechanism-Based Paradigms -- Section II. Non Invasive, Non Imaging, Assessment of Asymptomatic Atherosclerotic Cardiovascular Disease -- 14. Exercise Stress Testing in Asymptomatic Individuals and Its Relation to Subclinical Atherosclerotic Cardiovascular Disease -- 15. The Ankle Brachial Index -- 16. Arterial Elasticity/Stiffness -- 17. Assessment of Endothelial Function in Clinical Practice -- 18. Digital (Fingertip) Thermal Monitoring of Vascular Function: A Novel, Noninvasive, Nonimaging Test to Improve Traditional Cardiovascular Risk Assessment and Monitoring of Response to Treatments -- 19. Assessment of Macro- and Microvascular Function and Reactivity -- Section III. Non Invasive Structural Imaging of Asymptomatic Atherosclerotic Cardiovascular Disease -- 20. Coronary Artery Calcium Imaging -- 21. Noninvasive Ultrasound Imaging of Carotid Intima Thickness -- 22. Carotid Intima-Media Thickness: Clinical Implementation in Individual Cardiovascular Risk Assessment -- 23. Computed Tomographic Angiography -- 24. Role of Noninvasive Imaging using CT for Detection and Quantitation of Coronary Atherosclerosis -- 25. Noninvasive Coronary Plaque Characterization: CT Versus MRI -- 26. Magnetic Resonance Imaging -- 27. The Role of MRI in Examining Subclinical Carotid Plaque -- 28. Comprehensive Non-contrast CT Imaging of the Vulnerable Patient -- Section IV. Non Invasive Functional Imaging of Asymptomatic Atherosclerotic Cardiovascular Disease -- 29. Ultrasound Assessment of Brachial Artery Reactivity -- 30. Cardiac Imaging for Ischemia in Asymptomatic Patients: Use of Coronary Artery Calcium Scanning to Improve Patient Selection: Lessons from the EISNER Study -- 31. Targeted MRI of Molecular Components in Atherosclerotic Plaque -- 32. Noninvasive Imaging of the Vulnerable Myocardium: Cardiac MRI and CT Based -- Section V. Invasive (Intravascular) Risk Stratification for Detection of Vulnerable (High-Risk) Asymptomatic Atherosclerotic Plaques -- 33. Angiography for Detection of Complex and Vulnerable Atherosclerotic Plaque -- 34. Intravascular Characterization of Vulnerable Coronary Plaque -- 35. Detecting Vulnerable Plaque Using Invasive Methods -- 36. Assessment of Plaque Burden and Plaque Composition Using Intravascular Ultrasound -- 37. Vulnerable Anatomy; The Role of Coronary Anatomy and Endothelial Shear Stress in the Progression and Vulnerability of Coronary Artery Lesions: Is Anatomy Destiny? -- 38. Vasa Vasorum Imaging -- Section VI. Screening for Risk Assessment of Asymptomatic At-Risk Population and Identification of the Vulnerable Patient – The SHAPE Paradigm - 39. From Vulnerable Plaque to Vulnerable Patient – Part III. -- 40. Cost Effectiveness of Screening Atherosclerosis -- 41. Monitoring of Subclinical Atherosclerotic Disease -- 42. Implications of SHAPE Guideline for Improving Patient Compliance -- 43. The SHAPE Guideline: Why Primary Care Physicians Should Embrace It -- 44. Should We Treat According to the SHAPE Guidelines? -- 45. Duty-Bound: Rational Foundations of Clinical Strategies for Prevention of Cardiovascular Events -- 46. A Time to Live: Dynamic Changes in Risk as the Basis for Therapeutic Triage -- Section VII. Treatment of Asymptomatic Atherosclerotic Cardiovascular Disease and the Vulnerable Patients: Systemic Therapies -- 47. LDL Targeted Therapies -- 48. Antioxidants as Targeted Therapy: A Special Protective Role for Pomegranate and Paraoxonases (PONs -- 49. The Multiconstituent Cardiovascular Pill (MCCP): Challenges and Promises of Population Based Prophylactic Drug Therapy for Heart Attack Prevention and Eradication -- 50. Vaccine for Atherosclerosis: An Emerging New Paradigm -- Section VIII. Local and Focal Therapies for Stabilization of Vulnerable Arteries and Plaques -- 51. Drug-Eluting Stents: A Potential Preemptive Treatment Choice for Vulnerable Coronary Plaques -- 52. Intrapericardial Approach for Pancoronary Stabilization of the Vulnerable Arteries and Myocardium -- Section IX. Educations, Life Style Modifications and Non-Pharmacologic Treatments for Primary Prevention and Saving the Vulnerable -- 53. Dietary Management for Coronary Atherosclerosis Prevention and Treatment -- 54. Management of Preconditioning Physical Activity in a Vulnerable Patient: Getting in SHAPE -- 55. Last Chance for Prevention (Acute Prevention): Identification of Prodromal Symptoms and Early Heart Attack Care.
- Format
- e-Book
- Location
- Online
Comprehensive Cardiovascular Medicine in the Primary Care Setting
https://libcat.nshealth.ca/en/permalink/provcat28781
edited by Peter P. Toth, Christopher P. Cannon.
--New York, NY:
Humana Press
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Toth, Peter P
- Other Authors
- Cannon, Christopher P
- Responsibility
- edited by Peter P. Toth, Christopher P. Cannon
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2010
- Physical Description
- 1 online resource (xiii, 603 p. : ill.)
- Series Title
- Contemporary cardiology (Totowa, N.J. : Unnumbered)
- ISBN
- 9781603279635
- 9781603279628 (print ed.)
- Subjects (MeSH)
- Primary Health Care
- Subjects (LCSH)
- Cardiology
- Primary health care
- Contents
- Part I. Cardiovascular Disease Risk Factors -- 1. Cardiovascular Epidemiology and Characterization of Atherosclerotic Disease Risk Factors -- 2. Atrial Hypertension -- 3. Management Dyslipidemia -- 4. Obesity and Therapeutic Approaches to Weight Loss -- 5. Inflammatory Markers and Novel Risk Factors -- 6. Deciphering Cardiovascular Genomics and How They Apply to Cardiovascular Disease Prevention -- 7. The Metabolic Syndrome: 2009 -- 8. Chronic Kidney Disease in the Primary Care Setting -- Part II. Coronary Artery Disease -- 9. Evaluation of Chest Pain and Myocardial Ischemia -- 10. Unstable Angina and Non-ST Elevation Myocardial Infarction -- 11. ST Elevation Myocardial Infarction -- 12. Coronary Artery Stenting -- 13. Coronary Artery Bypass Grafting -- 14. Cardiac Rehabilitation -- Part III. Peripheral Forms of Venous and Arterial Disease -- 15. Carotid Artery Disease -- 16. Peripheral Arterial Disease -- 17. Deep Venous Thrombosis and Pulmonary Embolism -- 18. Pulmonary Hypertension and Cor Pulmonale -- 19. Diagnosis and Management of Ischemic Stroke -- 20. Aortic Aneurysms -- 21. Erectile Dysfunction -- Part IV. Cardiac Disease -- 22. Valvular Heart Disease -- 23. Pericardial Diseases -- 24. Common Atrial and Ventricular Arrhythmias -- 25. Evidence-based Management of the Patient with Congestive Heart Failure -- Part V. Cardiac Imaging -- 26. Coronary Calcium Scoring -- 27. Cardiac Computed Tomography -- 28. Cardiac Magnetic Resonance Imaging.
- Format
- e-Book
- Location
- Online
Bladder Tumors : Molecular Aspects and Clinical Management
https://libcat.nshealth.ca/en/permalink/provcat30059
edited by Vinata B. Lokeshwar, Axel S. Merseburger, Stefan H. Hautmann.
--Totowa, NJ:
Springer Science+Business Media
, c2011.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Lokeshwar, Vinata B
- Other Authors
- Merseburger, Axel S
- Hautmann, Stefan H
- Responsibility
- edited by Vinata B. Lokeshwar, Axel S. Merseburger, Stefan H. Hautmann
- Place of Publication
- Totowa, NJ
- Publisher
- Springer Science+Business Media
- Date of Publication
- c2011
- Series Title
- Cancer drug discovery and development
- ISBN
- 9781607619284
- Subjects (MeSH)
- Tumor Markers, Biological
- Urinary Bladder Neoplasms
- Format
- e-Book
- Location
- Online
A Pattern Approach to Lymph Node Diagnosis
https://libcat.nshealth.ca/en/permalink/provcat30155
by Anthony S-Y Leong.
--New York, NY:
Springer
, c2011.
- Available Online
- View e-Book
- Location
- Online
While a pattern approach to diagnosis is taught and practiced with almost every other tissue or organ in the body, the lymph node remains a mystery to most residents starting out in pathology and those pathologists with limited experience in the area. A Pattern Approach to Lymph Node Diagnosis demonstrates that a systematic approach to lymph node examination can be achieved through recognition of morphological patterns produced by different disease processes. It presents a combination of knowle…
- Available Online
- View e-Book
- Author
- Leong, Anthony S-Y
- Responsibility
- by Anthony S-Y Leong
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xiii, 418 p. : ill.)
- ISBN
- 9781441971760
- 9781441971753 (print ed.)
- Subjects (MeSH)
- Lymph Nodes - pathology
- Lymphatic Diseases - diagnosis
- Subjects (LCSH)
- Hematology
- Oncology
- Pathology
- Abstract
- While a pattern approach to diagnosis is taught and practiced with almost every other tissue or organ in the body, the lymph node remains a mystery to most residents starting out in pathology and those pathologists with limited experience in the area. A Pattern Approach to Lymph Node Diagnosis demonstrates that a systematic approach to lymph node examination can be achieved through recognition of morphological patterns produced by different disease processes. It presents a combination of knowledge-based assessment and pattern recognition for diagnosis covering the major primary neoplastic and non neoplastic diseases and metastatic tumors in lymph nodes. This volume demonstrates that lymph node compartments can be recognized histologically especially with the aid of immunohistological markers and how this knowledge can be employed effectively to localize and identify pathological changes in the different compartments in order to facilitate histological diagnosis. It also defines histological features that, because of their pathological occurrence in lymph nodes, are useful pointers to specific diagnoses or disease processes. The volume is organized in accordance with the primary pattern of presentation of each diagnostic entity. Differential diagnosis is discussed and each diagnostic entity is accompanied by color illustrations that highlight the diagnostic features. Immunohistochemistry, clinical aspects, relevant cytogenetics and molecular information of each entity is provided by an author who is an expert in lymphoproliferative diseases. An algorithmic approach to diagnosis is adopted at the end of each section by listing a set of questions that help to consider diagnostic entities that can present with the morphological features observed. A Pattern Approach to Lymph Node Diagnosis is an essential text for residents and fellows in pathology and general pathologists making first hand lymph node diagnoses as well as to hematologists and physicians who treat patients with lymphoprolifeative diseases.
- Contents
- Introduction -- Handling of the Lymph Node Biopsy -- Immunohistology and Other Special Techniques -- Anatomical and Functional Compartments -- Nodular Lymphoid Infiltrates -- Diffuse Lymphoid Infiltrates -- Defining Microscopic Features -- Nodal Involvement by Extranodal Lymphomas and Leukemias -- Needle Core Biopsies and Aspirates: Special Considerations.
- Format
- e-Book
- Location
- Online
