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Chronic Lymphocytic Leukemia

https://libcat.nshealth.ca/en/permalink/provcat44187
Michael Hallek, Barbara Eichhorst, Daniel Catovsky, editors. --Cham: Springer , 2019.
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This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in …
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Other Authors
Hallek, Michael
Eichhorst, Barbara
Catovsky, Daniel
Responsibility
Michael Hallek, Barbara Eichhorst, Daniel Catovsky, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (vi, 179 p.) : 23 illus., 19 illus. in color
Series
Hematologic Malignancies
Series Title
Hematologic malignancies (Series)
ISBN
9783030113926
9783030113919 (Print ed.)
9783030113933 (Print ed.)
ISSN
2197-9766
Subjects (MeSH)
Leukemia, Lymphocytic, Chronic, B-Cell
Specialty
Hematology
Medical Oncology
Abstract
This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.
Contents
Part I. Pathophysiology -- 1. Chronic Lymphocytic Leukemia: Who, How, and Where? -- Part II. Diagnostics -- 2. Laboratory Diagnosis of Chronic Lymphocytic Leukaemia -- Part III. Clinical Presentation -- 3. The Clinical Presentation of CLL -- Part IV. Prognostic Markers -- 4. Prognostic Markers -- Part V. Treatment -- 5. Guidelines for Diagnosis, Indications for Treatment, Response Assessment, and Supportive Management of Chronic Lymphocytic Leukemia: The 2018 Update -- 6. Initial Therapy of Chronic Lymphocytic Leukemia -- 7. CLL with Del (17p)/TP53 Mutation -- 8. Treatment of Relapsed and Refractory Chronic Lymphocytic Leukemia -- Part VI. Follow-up and Complications -- 9. Autoimmune Cytopenia in Chronic Lymphocytic Leukemia -- 10. Richter Syndrome -- Part VII. Related Entities -- 11. Prolymphocytic Leukaemia -- 12. Large Granular Lymphocyte Leukemia.
Format
e-Book
Location
Online
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Molecular Diagnostics in Cancer Patients

https://libcat.nshealth.ca/en/permalink/provcat44270
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors. --Singapore: Springer , 2019.
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This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services…
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Other Authors
Shukla, Kamla Kant
Sharma, Praveen
Misra, Sanjeev
Responsibility
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 341 p.) : 45 illus., 43 illus. in color
ISBN
9789811358777
9789811358760 (Print ed.)
9789811358784 (Print ed.)
Subjects (MeSH)
Biomarkers, Tumor
Molecular Diagnostic Techniques
Neoplasms - diagnosis
Pharmacogenetics
Specialty
Medical Oncology
Molecular Medicine
Abstract
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Contents
1. Recent Advances in Molecular Diagnostic Approaches for Cancer -- 2. Molecular Diagnosis of Gall Bladder Cancer -- 3. Molecular Diagnostics for Lung Cancer -- 4. Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors -- 5. Molecular Diagnostics in Melanoma: An Update -- 6. Molecular Diagnostics in Breast Cancer -- 7. Molecular Diagnostics in Non-Hodgkin Lymphoma -- 8. Molecular Diagnosis of Cervical Cancer -- 9. Molecular Diagnostics in Colorectal Cancer -- 10. Molecular Diagnostics in Pancreatic Cancer -- 11. Molecular Diagnostics in Head and Neck Squamous Cell Carcinoma -- 12. Molecular Diagnostic in Prostate Cancer -- 13. Molecular Diagnostics in Renal Cancer -- 14. Molecular Biomarkers and Urinary Bladder Cancer (UBC) -- 15. Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast -- 16. Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research -- 17. Molecular Diagnostics in Liver Cancer -- 18. Molecular Diagnosis of Uterine Cancer -- 19. Molecular Diagnosis in Ovarian Carcinoma.
Format
e-Book
Location
Online
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GI Surgery Annual. Volume 25

https://libcat.nshealth.ca/en/permalink/provcat44314
T. K. Chattopadhyay, editor-in-chief ; Peush Sahni, Sujoy Pal, editors. --Singapore: Springer , 2019.
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The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new deve…
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Other Authors
Chattopadhyay, T.K.
Sahni, Peush
Pal, Sujoy
Responsibility
T. K. Chattopadhyay, editor-in-chief ; Peush Sahni, Sujoy Pal, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (ix, 269 p.) : 34 illus., 26 illus. in color
Series
GI Surgery Annual
Series Vol.
25
Series Title
GI surgery annual
ISBN
9789811332272
9789811332265 (Print ed.)
9789811332289 (Print ed.)
ISSN
2367-3435
Subjects (MeSH)
Digestive System Diseases
Digestive System Surgical Procedures
Gastrointestinal Diseases - surgery
Specialty
Gastroenterology
Surgical Procedures, Operative
Abstract
The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new developments in the field. The GI Surgery Annual 25th Volume provides up-to-date information on current hot topics.
Contents
1. Esophagogastric Junction (EGJ) Carcinoma: An Updated Review -- 2. Superior Mesenteric Artery Syndrome -- 3. Biologics and Inflammatory Bowel Disease -- 4. New Surgical Modalities in the Management of Rectal Cancer -- 5. Tumor Markers in GI and HPB Cancers -- 6. IgG4 HPB Disease -- 7. ERCP-Induced Perforations -- 8. Bridging Therapy for HCC -- 9. Adjuncts to Liver Resection -- 10. Advances in Gastrointestinal Surgery.
Format
e-Book
Location
Online
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Preventive Oncology for the Gynecologist

https://libcat.nshealth.ca/en/permalink/provcat44349
Sumita Mehta, Anshuja Singla, editors. --Singapore: Springer , c2019.
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This book explores all aspects of preventive oncology of the female genital tract and provides readers with detailed insights on the topic. Preventive oncology has long been recognized as a pressing need, though formally few steps have been taken to actively promote it. The book’s respective chapters holistically cover the concept of cancer prevention for the female genital tract & breast. In addition, it explains the evidence-based value of each screening modality, and the rationale behind the…
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Other Authors
Mehta, Sumita
Singla, Anshuja
Responsibility
Sumita Mehta, Anshuja Singla, editors
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xviii, 450 p.) : 151 illus., 131 illus. in color
ISBN
9789811334382
9789811334375 (Print ed.)
9789811334399 (Print ed.)
Subjects (MeSH)
Genital Neoplasms, Female - diagnosis
Genital Neoplasms, Female - prevention & control
Women's Health
Specialty
Gynecology
Medical Oncology
Abstract
This book explores all aspects of preventive oncology of the female genital tract and provides readers with detailed insights on the topic. Preventive oncology has long been recognized as a pressing need, though formally few steps have been taken to actively promote it. The book’s respective chapters holistically cover the concept of cancer prevention for the female genital tract & breast. In addition, it explains the evidence-based value of each screening modality, and the rationale behind the recommended screening guidelines. In closing, the book highlights a wealth of recent evidence-based literature, making it a highly informative resource that will significantly broaden readers’ understanding of preventive oncology.
Contents
Part I. Endometrium -- 1. Endometrial Carcinoma: Epidemiology and Risk Factors -- 2. Role of Screening Modalities in Endometrial Cancer Detection -- 3. Endometrial Hyperplasia: Diagnosis and Management -- 4. Hereditary Endometrial and Ovarian Cancers -- 5. Chemoprevention for Endometrial Cancers -- Part II. Cervix -- 6 .Cervical Squamous Intraepithelial Lesions: A Pathologist’s Perspective -- 7. Cytology and HPV Testing in Primary Cervical Cancer Screening -- 8. Management of Abnormal Cytology -- 9. HPV Infection: Pathogenesis and Detection -- 10. Biomarkers for the Early Detection of Cervical Cancer -- 11. Colposcopic Principles and Tissue Basis -- 12. Colposcopic Features of Cervical Intraepithelial Lesions -- 13. Cervical Cancer Screening in Pregnancy -- 14. Cervical Cancer Screening in Low-Resource Settings -- 15. Ablative Methods for Treatment of Intraepithelial Lesions -- 16. Management of High-Grade Lesions -- Part III. Ovary -- 17. Epidemiology and Risk Factors for Ovarian Cancer -- 18. Role of Tumor Markers -- 19. Screening for Ovarian Cancer -- 20. Prevention of Ovarian Cancer -- Part IV. Vulva and Vagina -- 21. Risk Factors and Classification of Vulvar Intraepithelial Lesions -- 22. Detection of Precancerous Lesions of the Vulva -- 23. Management of Vulvar Intraepithelial Neoplasia -- 24. Vaginal Cancer: Epidemiology and Risk Factors -- 25. Vaginal Intraepithelial Neoplasia (VaIN): Diagnosis and Management -- Part V. Breast -- 26. Epidemiology of Breast Cancer: Current Figures and Trends -- 27. Breast Cancer: Role of Imaging -- 28. Breast Cancer Screening Modalities -- 29. Breast Cancer Risk Assessment and Genetic Testing -- 30. Preinvasive Breast Lesions: Detection and Management -- Part VI. Newer Concepts -- 31. Contribution of the Gut and Vaginal Microbiomes to Gynecological Cancers -- 32. HPV Infection and Gynecological Cancers -- 33. Advances in -- 34. Update on HPV Vaccination.
Format
e-Book
Location
Online
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Biomarkers in Cancer Therapy : Liquid Biopsy Comes of Age

https://libcat.nshealth.ca/en/permalink/provcat44460
Hideaki Shimada, editor. --Singapore: Springer , 2019.
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This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which serve as the basis for exploring key research questions for future clinical trials in the book’s second half. The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is…
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Other Authors
Shimada, Hideaki
Responsibility
Hideaki Shimada, editor
Place of Publication
Singapore
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (viii, 157 p.) : 22 illus., 17 illus. in color
ISBN
9789811372957
9789811372940 (Print ed.)
9789811372964 (Print ed.)
9789811372971 (Print ed.)
Subjects (MeSH)
Biomarkers
Liquid Biopsy
Neoplasms - diagnosis
Specialty
Clinical Laboratory Techniques
Medical Oncology
Abstract
This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which serve as the basis for exploring key research questions for future clinical trials in the book’s second half. The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is focused on proteomics or gene analysis of resected tissue, diagnostic markers have since become significant in terms of gauging the effectiveness of molecularly targeted drugs or the likelihood of a favorable prognosis. In addition, conventional treatment strategy, which draws on archives of resected tissue samples, is now gradually being replaced by monitoring with the use of liquid biopsy, which is poised to become the new mainstream in molecular targeting therapy. The contributing authors discuss in detail biomarkers, molecular targets for treatment, monitoring markers to evaluate treatment responses, prognostic markers, and screening and early diagnosis. Accordingly, this excellent collection of texts will benefit not only oncologists, but also medical and biological researchers and pharmaceutical scientists involved in the latest cancer research.
Contents
Part I. Various Strategies to Detect Cancer -- 1. Liquid Biopsy Diagnostics Using Extracellular Vesicles -- 2. Cell-Free DNA -- 3. Autoantibody in Cancer -- 4. Serum Angiogenic Factors as Cancer Biomarkers -- 5. Biomarkers of Cancer Stem Cells in Cancer Therapy -- Part II. Biomarkers for Individual Cancers -- 6. Specifics 1: Head and Neck Cancer and Esophageal Cancer -- 7. Biomarkers in Gastric Cancer -- 8. Liquid Biopsy in Hepatocellular Carcinoma -- 9. Biomarkers of Pancreatic Cancer -- 10. Biomarkers of Lung Cancer: Liquid Biopsy Comes of Age -- 11. Biomarkers for Breast Cancer Treatment -- 12. Biomarkers of Prostate Cancer -- 13. Biomarkers of Gynecological Cancers -- 14. Biomarkers of Malignant Pleural Mesothelioma.
Format
e-Book
Location
Online
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Biomarkers in Inflammatory Bowel Diseases

https://libcat.nshealth.ca/en/permalink/provcat44481
Nik Sheng Ding, Peter De Cruz, editors. --Cham: Springer , c2019.
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This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, p…
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Other Authors
Sheng Ding, Nik
De Cruz, Peter
Responsibility
Nik Sheng Ding, Peter De Cruz, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xvii, 365 p.) : 35 illus., 30 illus. in color
ISBN
9783030114466
9783030114459 (Print ed.)
9783030114473 (Print ed.)
Subjects (MeSH)
Biomarkers
Inflammatory Bowel Diseases - diagnosis
Specialty
Clinical Laboratory Techniques
Gastroenterology
Abstract
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
Contents
1. Introduction -- Part I. Background to Biomarkers -- 2. Clinical Risk Factors: Lessons from Epidemiology -- 3. Disease Modification in Crohn’s Disease -- 4. Personalized Medicine - Dream or Reality? -- 5. Clinical Trial Design to Facilitate Biomarker Discovery -- Part II. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Crohn’s Disease -- 6. Luminal Crohn’s Disease -- 7. Fibrosis and Stricturing Disease in Crohn’s Disease -- 8. Postoperative Crohn’s Disease -- 9. Perianal Crohn’s Disease -- Part III. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Ulcerative Colitis -- 10. Biomarkers in Acute Severe Ulcerative Colitis -- 11. Chronic Active Ulcerative Colitis -- 12. Refractory Proctitis -- 13. UC Surveillance -- 14. The Role of Biomarkers in the Ileal Anal Pouch -- Part IV. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Specialised Scenarios -- 15. Extra-intestinal Manifestations in Inflammatory Bowel Disease: Diagnosis and Management -- 16. Primary Sclerosing Cholangitis Overlapping with IBD -- 17. Pregnancy and IBD -- 18. Nutrition in IBD -- 19. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Thiopurines -- 20. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Biologics -- 21. Drug Toxicity: Personalising IBD Therapeutics–The Use of Genetic Biomarkers to Reduce Drug Toxicity -- 22. Biomarkers for Remote Monitoring -- Part V. Scientific Platforms for Biomarker Discovery -- 23. Exposome and Diet -- 24. The Microbiome in IBD -- 25. Metabolic Profiling in IBD -- 26. Innate and Adaptive Immunology -- 27. Genetic and Genomic Markers for Prognostication -- 28. Risk Alleles for Drug Targets: Genomic Markers of Drug Response -- Part VI. Conclusion -- 29. Big Data Meets Real World! The Use of Clinical Informatics in Biomarker Research -- 30. Bringing It Altogether: A Systems Biology Approach to Biomarkers in Inflammatory Bowel Disease.
Format
e-Book
Location
Online
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Postmenopausal Diseases and Disorders

https://libcat.nshealth.ca/en/permalink/provcat44510
edited by Faustino R. Pérez-López. --Cham: Springer , c2019.
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Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes th…
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Pérez-López, Faustino R.
Responsibility
edited by Faustino R. Pérez-López
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (ix, 484 p.) : 45 illus., 40 illus. in color
ISBN
9783030139360
9783030139353 (Print ed.)
9783030139377 (Print ed.)
9783030139384 (Print ed.)
Subjects (MeSH)
Postmenopause - physiology
Women's Health
Specialty
Gynecology
Women's Health
Abstract
Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes the development of quick and easy-to-use assessment tools and predictive markers of age-related co-morbidities. As such, the book is a valuable resource for researchers and clinicians alike.
Contents
1. Assisted Reproductive Technology in Peri- and Postmenopausal Women -- 2. Turner Syndrome: Primary Amenorrhea from Adolescence to Ageing -- 3. Premature Ovarian Insufficiency -- 4. Human Papilloma Virus Infection and Cancer Risk in Peri- and postmenopausal Women -- 5. Risk and Protective Factors for Sporadic Ovarian and Fallopian Tube Cancer in Postmenopausal Women -- 6. Vulvar Dermatoses and Menopause -- 7. Bladder Pain Syndrome/Interstitial Cystitis -- 8. Overactive Bladder -- 9. Management of Female Stress Urinary Incontinence -- 10. Screening and Management of Female Sexual Dysfunction During the Second Half of Life -- 11. Current Treatment Modalities for the Genitourinary Syndrome of Menopause -- 12. Laser Treatment for Vulvovaginal Atrophy -- 13. Laser Treatments in Female Urinary Incontinence -- 14. Metabolic Syndrome and Excessive Body Weight in Peri- and Postmenopausal Women -- 15. Metabolic Syndrome and Atherosclerosis in Non-diabetic Postmenopausal Women -- 16. Polycystic Ovary Syndrome related Risks in Postmenopausal Women -- 17. Sleep and Sleep Disturbances in Climacteric Women -- 18. Impact of Menopause on Brain Functions -- 19. Vasomotor Symptoms: Clinical Management -- 20. Vasomotor Symptoms, Metabolic Syndrome and Cardiovascular Risks -- 21. A Woman's Heart Needs Her Hormones -- 22. Menopause Hormone Therapy to Prevent Chronic Conditions -- 23. Selective Estrogen Receptor Modulators (SERMs): State of the Art -- 24. Management of Osteoporosis in Postmenopausal Women -- 25. Anabolic Agents for the Treatment of Postmenopausal Osteoporosis -- 26. The Links Between Osteoporosis and Sarcopenia in Women -- 27. Female Sarcopenic Obesity -- 28. Cognitive Decline in Women: The Zarademp Study -- 29. Managing Menopause and Post-reproductive Health: Beyond Hormones and Medicines -- 30. Effect of Exercise on Menopausal Prevalent Conditions.
Format
e-Book
Location
Online
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Tumor Angiogenesis : A Key Target for Cancer Therapy

https://libcat.nshealth.ca/en/permalink/provcat44567
edited by Dieter Marmé. --Cham: Springer , c2019.
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Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not a…
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Other Authors
Marmé, Dieter
Responsibility
edited by Dieter Marmé
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource
Series Title
Springer reference
ISBN
9783319312156
Subjects (MeSH)
Angiogenesis Inhibitors - therapeutic use
Neovascularization, Pathologic - physiology
Neovascularization, Pathologic - therapy
Neoplasms - blood supply
Neoplasms - therapy
Specialty
Medical Oncology
Molecular Medicine
Notes
"Living reference work."
Abstract
Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies.   The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.
Contents
Angiopoietins and TIE Receptors in Lymphangiogenesis and Tumor Metastasis -- Anti-Angiogenic Cancer Therapy: Development of Resistance -- Anti-Angiogenic Targeting in Metastatic Colorectal Cancer Therapy -- Anti-Angiogenic Targets: Angiopoietin and Angiopoietin-Receptors -- Anti-Angiogenics and Radiation Therapy -- Anti-Angiogenics in Gastroesophageal Cancer -- Anti-Angiogenics in Hepatocellular Cancer Therapy -- Anti-angiogenics in Kidney Cancer Therapy -- Anti-Angiogenics in Pancreatic Cancer Therapy -- Antiangiogenics in Brain Metastases: Perspectives and Experiences -- Benefits and Pitfalls of Tumor Vessel Normalization -- Biomarkers for Anti-angiogenic Therapy -- Combination of Antiangiogenics and Other Targeted Therapies -- Controlling Vascular Permeability: How Does It Work and What Is the Impact on Normal and Pathological Angiogenesis -- Cytotoxics and Anti-Angiogenics: Metronomic Therapies -- Endothelial Cell-Cell Junctions in Tumor Angiogenesis -- Imaging Tumor Angiogenesis -- Inhibition of Tumor Angiogenesis in GIST Therapy -- Inhibition of Tumor Angiogenesis in the Treatment of Lung Cancer -- Mechanisms of Anti-Angiogenic Therapy -- Mechanisms of Tumor Angiogenesis -- Pathology of Tumor Angiogenesis -- Significance and Molecular Regulation of Lymphangiogenesis in Cancer -- The Impact of Endothelial Transcription Factors in Sprouting Angiogenesis -- The Implication of Antiangiogenic Treatment of Malignancies on Human Metabolism -- The Role of the VEGF Signaling Pathway in Tumor Angiogenesis -- The Role of VEGF in Controlling Vascular Permeability -- The Value of Anti-Angiogenics in Bladder Cancer Therapy -- The Value of Anti-Angiogenics in Cervical Cancer Therapy -- The Value of Anti-Angiogenics in Head and Neck Cancer Therapy -- The Value of Anti-Angiogenics in Multiple Myeloma Therapy -- The Value of Anti-Angiogenics in Ovarian Cancer Therapy -- The Value of Anti-Angiogenics in Primary Brain Tumor Therapy -- The Value of Anti-Angiogenics in Prostate Cancer Therapy -- The Value of Anti-Angiogenics in Soft Tissue Sarcoma Therapy -- The Value of Antiangiogenics in Breast Cancer Therapy.
Format
e-Book
Location
Online
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Cutaneous Melanoma

https://libcat.nshealth.ca/en/permalink/provcat44575
edited by Charles Balch ... [and 9 others]. ([6th ed.]) --Cham: Springer , c2019.
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Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors…
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Balch, Charles
Responsibility
edited by Charles Balch ... [and 9 others]
Edition
[6th ed.]
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource
Series Title
Springer reference
ISBN
9783319460291
Subjects (MeSH)
Melanoma
Specialty
Dermatology
Medical Oncology
Notes
"Living reference work."
Abstract
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
Contents
A History of Melanoma: From Hunter to Morton -- Acquired Precursor Lesions and Phenotypic Markers of Increased Risk for Cutaneous Melanoma -- Acral Lentiginous Melanoma -- Adjuvant Systemic Therapy for High-Risk Melanoma Patients -- Axillary and Epitrochlear Lymph Node Dissection for Melanoma -- Biology of Melanocytes and Primary Melanoma -- Biomarkers for Melanoma -- Biopsy of Suspected Melanoma -- Biopsy of the Sentinel Lymph Node -- Cellular Therapy for Melanoma -- Checkpoint Inhibitors in the Treatment of Metastatic Melanoma -- Classification and Histopathology of Melanoma -- Clinical Epidemiology of Melanoma -- Clinical Genetics and Risk Assessment of Melanoma -- Clinical Presentations of Melanoma -- Cytokines (IL-2, IFN GM-CSF etc) Melanoma -- Dermatological Complications of Systemic Therapies for Melanoma -- Dermoscopy/Confocal Microscopy -- Diagnosis of Stage IV Melanoma -- Evolving Role of Chemotherapy-Based Treatment of Metastatic Melanoma -- Hyperthermic Regional Perfusion for Melanoma of the Limbs -- Immunology of Melanoma -- Inguinofemoral, Iliac/Obturator, and Popliteal Lymphadenectomy for Melanoma -- Isolated Limb Infusion for Melanoma -- Lentigo Maligna Melanoma -- Local and Recurrent Regional Metastases of Melanoma -- Local Melanoma Recurrence, Satellitosis, and In-transit Metastasis: Incidence, Outcomes, and Selection of Treatment Options -- Lymphoscintigraphy in Patients with Melanoma -- Managing Checkpoint Inhibitor Symptoms and Toxicity -- Melanoma Brain Metastases: Unique Biology and Implications for Systemic Therapy -- Melanoma Prevention and Screening -- Melanoma Vaccines -- Models for Predicting Melanoma Outcome -- Molecular Epidemiology of Melanoma -- Molecular Pathology and Genomics of Melanoma -- Molecularly Targeted Therapy for Patients with BRAF Wild-Type Melanoma -- Mucosal Melanoma -- Neck Dissection and Parotidectomy for Melanoma -- Neoadjuvant Systemic Therapy for High-Risk Melanoma Patients -- Novel Immunotherapies and Novel Combinations of Immunotherapy -- Pregnancy and the Use of Hormones in Melanoma Patients -- Radiotherapy for Distant Metastases -- Radiotherapy for Primary and Regional Melanoma -- Sequencing and Combinations of Molecularly Targeted and Immunotherapy for BRAF-Mutant Melanoma -- Surveillance and Follow-Up of Melanoma Patients -- Systemic Therapy for Mucosal, Acral and Uveal Melanoma -- Targeted Therapies for BRAF-Mutant Metastatic Melanoma -- Treatment of Primary Melanomas.
Format
e-Book
Location
Online
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Varicocele and Male Infertility : A Complete Guide

https://libcat.nshealth.ca/en/permalink/provcat44741
Sandro C Esteves, Chak-Lam Cho, Ahmad Majzoub, Ashok Agarwal, editors. --Cham: Springer , c2019.
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This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventi…
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Other Authors
Esteves, Sandro C.
Cho, Chak-Lam
Majzoub, Ahmad
Agarwal, Ashok
Responsibility
Sandro C Esteves, Chak-Lam Cho, Ahmad Majzoub, Ashok Agarwal, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xxvii, 638 p.) : 91 illus., 68 illus. in color
ISBN
9783319791029
9783319791012 (Print ed.)
9783319791036 (Print ed.)
Subjects (MeSH)
Infertility, Male - etiology
Infertility, Male - therapy
Varicocele - complications
Varicocele - diagnosis
Varicocele - surgery
Specialty
Men's Health
Reproductive Medicine
Abstract
This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress-associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content. Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.
Contents
Part I: Varicocele Origin and Pathology -- Anatomic theories of varicocele origin -- Scrotal hyperthermia, hormonal disturbances, testicular hypoperfusion, and backflow of toxic metabolites in varicocele -- Genetics and epigenetics of varicocele pathophysiology -- Oxidative stress and varicocele pathophysiology -- Proteomic and metabolomic profile of semen and seminal plasma in varicocele -- Experimental varicocele -- Part II: Clinical Evaluation of Varicocele -- Epidemiology of varicocele in pediatric, adolescent and adult populations -- Association between varicocele and infertility -- Varicocele clinical diagnosis and grading -- Imaging and other diagnostic modalities in varicocele diagnosis -- Conventional semen analysis and specialized sperm function tests in patients with varicocele -- Endocrine testing and the association between varicocele and hypogonadism -- Varicocele and orchialgia -- Part III: Therapy of Varicocele -- The evolution and refinement of varicocele treatment: A historical perspective -- Medical therapy in varicocele-related infertility -- Macroscopic surgical techniques for varicocele repair -- Microscopic surgical techniques for varicocele repair -- Laparoscopic techniques for varicocele repair -- Interventional radiology for varicocele treatment -- Robotic assisted microsurgical varicocelectomy -- Effect of varicocele treatment on conventional semen analysis -- Effect of varicocele treatment on oxidative stress markers and sperm DNA fragmentation -- Effect of varicocele treatment on natural pregnancy outcome -- Effect of varicocele treatment on assisted reproductive technology (ART) pregnancy outcome -- Varicocele and azoospermia -- Prognostic factors for a favorable outcome after varicocele repair in adults with infertility -- Management of recurrent varicocele -- Cost-effectiveness analysis of varicocele repair and assisted reproductive technology -- Management of pediatric and adolescent varicocele -- Part IV: Controversies with Varicocele -- Is varicocele a bilateral disease? -- Why is subclinical varicocele considered a different entity? -- Why is it that not all men with varicocele are infertile? -- Is there a role for testicular biopsy in men with varicocele? -- Should bilateral varicocele repair be recommended in cases of a clinical varicocele and contralateral subclinical varicocele? -- Is there any role for intraoperative ultrasound during varicocele repair? -- Is there any role for indocyanine green angiography in testicular artery preservation during microsurgical subinguinal varicocelectomy? -- Should a varicocele be repaired before assisted reproductive technology treatment? -- Should a varicocele be repaired in non-infertile patients with hypogonadism? -- What should be the ideal control group in clinical trials investigating the role of varicocele and its treatment on fertility outcomes? -- Part V: Debate (Pro and Con) over Varicocele -- Should SDF testing be used in men with varicocele? -- Should varicocele be repaired before ART? -- Should varicocele be repaired in azoospermic infertile men? -- Should varicocele be managed surgically or radiographically? -- Part VI: Clinical Case Scenarios Involving Varicocele -- Grade 1 varicocele and borderline/normal conventional semen analysis -- Grades 2/3 varicocele and normal conventional semen analysis -- Clinical varicocele and severely abnormal semen analysis in a couple considering ART whose female partner is over 36 years old -- Asymptomatic male with left grade 3 varicocele and 2 children desiring vasectomy with low testosterone -- Symptomatic male with subclinical varicocele found on ultrasound evaluation -- Recurrent grade 2/3 varicocele after microsurgical varicocelectomy and abnormal semen parameters in a couple attempting conception for >3 years -- Grade 2/3 varicocele in a 15-year-old healthy boy with normal testis volume (and normal semen analysis) with a history of varicocele and infertility in his father -- Part VII: Clinical Practice Guidelines for Varicocele -- Adult varicocele diagnosis and treatment -- Pediatric and adolescent varicocele diagnosis and treatment -- Sperm DNA fragmentation testing and varicocele -- Grade of evidence on varicocele treatment -- A ‘Strengths-Weakness-Opportunities-Threats’ (SWOT) analysis of varicocele-related infertility and its diagnosis and management.
Format
e-Book
Location
Online
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Adolescent Health and Wellbeing : Current Strategies and Future Trends

https://libcat.nshealth.ca/en/permalink/provcat44756
Alessandro Pingitore, Francesca Mastorci, Cristina Vassalle, editors. --Cham: Springer , c2019.
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This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and t…
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Other Authors
Pingitore, Alessandro
Mastorci, Francesca
Vassalle, Cristina
Responsibility
Alessandro Pingitore, Francesca Mastorci, Cristina Vassalle, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xii, 352 p.) : 45 illus., 37 illus. in color
ISBN
9783030258160
9783030258153 (Print ed.)
9783030258177 (Print ed.)
9783030258184 (Print ed.)
Subjects (MeSH)
Adolescent
Health Promotion
Preventive Medicine
Social Determinants of Health
Subjects (LCSH)
Pediatrics
Health promotion
Primary care (Medicine)
Medical policy
Child psychiatry
Specialty
Adolescent Health
Abstract
This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and the clinical and prognostic implications of primordial prevention in healthy adolescents. All of these elements are subsequently reviewed using a multidimensional approach, in order to offer extensive information on the complex changes that characterize adolescents’ physiological, psychological, and neurobiological development. In addition, the book depicts the preventive strategies currently used in various social settings (school, family, sport club, health policies) aimed not only at reducing lifestyle risk behaviors, but also at improving resilience, happiness, social involvement, self-esteem, and sociability. This update is essential in the light of the fact that, to date, prevention has mainly been directed towards adolescents with physical or mental disorders rather than their healthy peers. As such, the book offers a valuable tool for pediatricians, child and adolescents psychiatrists, and for all professionals involved in Health Promotion and Disease Prevention.
Contents
Part I. Primordial Prevention: General Aspects - 1. Preventive Primordial Strategies: Times Are Changing -- 2. Fetal Programming of Adult Disease in a Translational Point of View -- 3. Physical Activity, Sedentary Behaviour and Mental Health in Young People: A Review of Reviews -- 4. Habits and Quality of Diet -- 5. Biochemical Markers in Primordial Prevention: Premises and Promises -- Part II. Adolescents’ Mental Health and Well-Being -- 6. Prenatal and Early Postnatal Influences on Neurodevelopment: The Role of Epigenetics -- 7. The Role of Environmental Enrichment on Neurodevelopment: Emotion Regulation in Adolescence as a Model Paradigm -- 8. Relationship Between Emotions, Sleep and Well-Being -- 9. Adolescents in the 21st Century: Back to Dialogue from Marked Lives vs Dreamed Lives -- Part III. Adolescence and the Social Determinants of Health -- 10. Adolescence and Social Determinants of Health: Family and Community -- 11. The Role of Well-Being in the School of Inclusion -- 12. Two-Faced Janus: The Role of Peers in Adolescence -- Part IV. The Digital Era in Adolescent’s Health and Well-Being -- 13. Adolescence Between Past and Future -- 14. e-Health Strategies -- 15. Images and Perspectives of Play for Children’s and Adolescents’ Well-being -- 16. New Perspectives for Multidisciplinary and Integrated Strategies of Adolescent Health and Well-being.
Format
e-Book
Location
Online
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Immunohistochemistry in Tumor Diagnostics

https://libcat.nshealth.ca/en/permalink/provcat42539
Muin S.A. Tuffaha, Hans Guski, Glen Kristiansen. --Cham: Springer , c2018.
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This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics. Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunopro…
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Author
Tuffaha, Muin S.A
Other Authors
Guski, Hans
Kristiansen, Glen
Responsibility
Muin S.A. Tuffaha, Hans Guski, Glen Kristiansen
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xii, 264 p.) : 139 illus. in color
ISBN
9783319535777
9783319535760 (print ed.)
9783319535784 (print ed.)
9783319851884 (print ed.)
Subjects (MeSH)
Immunohistochemistry - methods
Neoplasms - diagnosis
Specialty
Clinical Laboratory Techniques
Medical Oncology
Abstract
This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics. Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunoprofile of common tumors throughout all systems of human body. With numerous color figures and detailed flowcharts, it appeals to all pathologists be they young residents in training who want a brief introduction to this technique, or specialists in need of a reliable and comprehensive reference resource in tumors diagnostics.
Contents
Immunohistochemistry in tumor diagnosis -- Immunohistochemical markers for the diagnosis of epithelial tumors -- Markers and immunoprofile of upper respiratory tract and pulmonary tumors -- Markers and immunoprofile of thymic epithelial tumors -- Markers and immunoprofile of heart and pericardium tumors -- Markers and immunoprofile of tumors of the oral cavity and salivary gland tumors -- Markers and immunoprofile of tumors gastrointestinal tract -- Markers and immunoprofile of exocrine pancreatic tumors -- Markers and immunoprofile of hepatobiliary tumors -- Markers and immunoprofile of hepatobiliary tumors -- Markers and immunoprofile of breast tumors -- Markers and immunoprofile of tumors of female reproductive organs -- Markers and immunoprofile of renal and urinary tract tumors -- Markers and immunoprofile of male genital tract tumors -- Markers and immunoprofile of endocrine and neuroendocrine tumors -- Markers and immunoprofile of mesothelioma tumors of the peritoneum -- Markers and immunoprofile of lymphoid tissue neoplasms -- Markers and immunoprofile of myeloid neoplasm -- Markers and immunoprofile of Mastocytosis -- Markers and immunoprofile of histiocytic and dendritic cell tumors -- Markers and immunoprofile of skin tumors -- Markers and immunoprofile of melanocytic tumors -- Markers and immunoprofile of fibroblastic, myofibroblastic and fibrohistiocytic tumors -- Markers and immunoprofile of muscle tumors -- Markers and immunoprofile of vascular and perivascular tumors -- Markers and immunoprofile of adipocytic tumors -- Markers and immunoprofile of peripheral nerve- and nerve sheet tumors -- Markers and immunoprofile of the central nervous system tumors -- Markers and immunoprofile of Ewing's sarcoma / primitive neuroectodermal tumors (PNET) -- Markers and immunoprofile of extraskeletal osseous and cartilaginous tumors -- Markers and immunoprofile of miscellaneous tumors and tumors of uncertain differentiation -- Markers to assist the diagnosis of dysplasia and malignant transformation -- Recommendations for the utility of immunohistochemistry in tumor diagnosis.
Format
e-Book
Location
Online
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Neonatology : A Practical Approach to Neonatal Diseases

https://libcat.nshealth.ca/en/permalink/provcat42557
Giuseppe Buonocore, Rodolfo Bracci, Michael Weindling, editors. (Second edition) --Cham: Springer , c2018.
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This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addit…
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Other Authors
Buonocore, Giuseppe
Bracci, Rodolfo
Weindling, Michael
Responsibility
Giuseppe Buonocore, Rodolfo Bracci, Michael Weindling, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiii, 2528 p.) : 568 illus., 358 illus. in color
Series Title
Springer reference
ISBN
9783319294896
9783319294872 (print ed.)
Subjects (MeSH)
Infant, Newborn, Diseases
Neonatology
Specialty
Neonatology
Notes
"eReference"--Publisher.
Abstract
This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.
Contents
Acute and Chronic Renal Failure in the Newborn Infant -- Anemia in the Neonatal Period -- Apnea of Prematurity and Sudden Infant Death Syndrome -- Bilirubin Metabolism, Unconjugated Hyperbilirubinemia, and Physiologic Neonatal Jaundice -- Biochemical Basis of Hypoxic-Ischemic Encephalopathy -- Blood Pressure Disorders in the Neonate: Hypotension and Hypertension -- Brain Development and Perinatal Vulnerability to Cerebral Damage -- Bronchopulmonary Dysplasia/Chronic Lung Disease of the Newborn -- Calcium and Phosphorus Homeostasis of Newborns: Pathophysiology -- Cardiac Emergencies in the Newborn -- Cardiovascular Physiology, Pathology, and Clinical Investigation in Neonatal Medicine -- Care of Extremely Low Birth Weight Infants and Timing of Discharge. Information and Psychosocial Intervention in Neonatology. -- Cerebral Hemorrhage in Newborns -- Cerebral Plasticity and Functional Reorganization in Children with Congenital Brain Lesions -- Clinical Aspects and Treatment of the Hypoxic-Ischemic Syndrome -- Coagulation Disorders in Newborns: Clinical Aspects of Platelet Disorders -- Congenital Immunodeficiencies in Newborns -- Congenital Malformations and Syndromes: Early Diagnosis and Prognosis in Neonatal Medicine -- Congenital Malformations of the Brain: Prenatal Diagnosis, Spectrum and Causes -- Continuous Positive Airways Pressure and other Non-Invasive Ventilation Techniques in Newborns -- Control of Breathing in Newborns -- Creactive Protein and Procalcitonin: Reference Intervals in Term and Preterm Newborns -- Development and General Characteristics of Preterm and Term Newborn -- Developmental Pharmacology and Therapeutics in Neonatal Medicine -- Diagnosis and Treatment of Renal and Urinary Tract Malformations in Newborns -- Diagnosis of Fetal Distress -- Disorders of Sexual Development in Newborns -- Early Detection of Neonatal Depression and Asphyxia -- Early Diagnosis of Congenital Heart Disease: When and How to Treat -- Early Markers of Poor Outcome in Neonatal Medicine -- Endocrine Diseases and Disorders of Thyroid Function in Newborns -- Enteral Feeding of the Very Low Birth Weight Infant -- Environment and Early Developmental Care for Newborns -- Epidemiology of Adverse Cerebral Outcome of Newborns -- Epidemiology: Mortality, Morbidity and Follow Up of High Risk Newborns -- Epigenetic Mechanisms -- Esophageal Atresia of Newborns -- Ethical Problems in Neonatal Medicine -- Extracorporeal Membrane Oxygenation for Neonates -- Feeding the Term Infant: Human Milk and Formulas -- Fetal and Neonatal Hydrops -- Fetal Infections: Congenital Syphilis and Tuberculosis -- Fetal Infections: Cytomegalovirus, Herpes Simplex, and Varicella -- Fetal infections: Rubella, HIV, HCV, HBV, and Human Parovirus B19 -- Follow-up Outcomes of High Risk Infants -- Fundamentals of Feto-Neonatal Immunology and Its Clinical Relevance -- Gastroenteritis and Intractable Diarrhea in Newborns -- Gastrointestinal Malformations of Newborns -- Guidelines and Protocols for Newborns -- Hematology and Immunology of Newborns: Overview -- Hirschsprung's Disease in Newborns -- Hormones and Gastrointestinal Function of Newborns -- Human Milk and Formulas for Neonatal Nutrition -- In Vitro Fertilization and Multiple Pregnancies -- Inborn Errors of Metabolism and Newborns -- Infants of Diabetic Mothers -- Infants of Smoking Mothers -- Inflammation and Perinatal Brain Injury -- Inflammatory Mediators in Neonatal Asphyxia and Infection -- Intrauterine Growth Restriction: Obstetric and Neonatal Aspects. Intervention Strategies. -- Kernicterus, Bilirubin-Induced Neurological Dysfunction, and New Treatments for Unconjugated Hyperbilirubinemia in Neonates -- Laboratory Medicine: Reference Intervals for Laboratory Tests and Procedures -- Laboratory Medicine: Reference Values and Evidence Based Medicine -- Late Preterm Infants at Risk for Short-Term and Long Term Morbidity and Mortality -- Lung Diseases: Problems of Steroid Treatment of Fetus and Newborn -- Lung Diseases: Surfactant Replacement Therapy in Newborns -- Lung Ultrasounds in Neonatal Diagnostic -- Malformations of Cortical Development in Newborns: Genetic Aspects -- Meconium Aspiration Syndrome -- Meconium Plug Syndrome -- Micronutrients and Vitamins of Newborns -- Molecular Structure of Surfactant: Biochemical Aspects in Newborns -- Necrotizing Enterocolitis of Newborns -- Neonatal Anesthesia -- Neonatal Bacterial and Fungal Infections -- Neonatal Care in the Delivery Room: Initial Management and Approach To Low Risk Newborns -- Neonatal Cholestasis-Conjugated Hyperbilirubinemia -- Neonatal Electroencephalography -- Neonatal Hereditary Neutropenia -- Neonatal Lung Development and Pulmonary Malformations -- Neonatal Malignancies -- Neonatal Orthopedic Surgery -- Neonatal Pain: Neurophysiology, Recognition, Prevention and Management with Non-Pharmacological Interventions -- Neonatal Pulmonary Physiology of Term and Preterm Newborns -- Neonatal Seizuresá -- Neonatal Septic Shock -- Neonatal Skin Disorders -- Neonatal Stroke: Clinical Presentation, Imaging, Treatment, and Prognosis -- Neonatal Stroke: Mechanisms -- Neonatal Transport Services -- Neonatal Viral Infections: Enteroviruses and Respiratory Syncytial Virus -- Neonatology and the Law -- Neuroimaging Studies of Newborns -- Neurological Examination of the Newborn Infantá -- Neuromuscular Disorders in Newborns -- Neuroprotective Strategies for Newborns -- Normal and Abnormal Neurodevelopmental and Behavioral Outcomes of Very Low-Birth Weight (VLBW) Infants -- Nutritional Recommendations for the Very Low Birth Weight Newborn -- Ocular Malformations in Newborns -- Organization of Perinatal Care. Training of Doctors and Nurses -- Orofacial Malformations -- Oxygen Saturation Monitoring in Neonatal Period -- Oxygen Toxicity in Newborns -- Parenteral Nutrition of Newborns -- Patent Ductus Arteriosus in Newborns -- Pathologic Unconjugated Hyperbilirubinemia, Isoimmunization, Abnormalities of Red Blood Cells, and Infections -- Pathology and Treatment of Liver Diseases in Newborns -- Pathophysiology of Coagulation and Deficiencies of Coagulation Factors in Newborns -- Pathophysiology of Fetal and Neonatal Kidneys -- Persistent Pulmonary Hypertension of the Newborn and Congenital Diaphragmatic Hernia: Nitric Oxide Therapy in Neonatology -- Physical Environment for Newborns: the Thermal Environment -- Physical Examination of the Newborn -- Physiology and Abnormalities of Leukocytes in Newborns -- Physiology of the Gastrointestinal Tract in Newborns -- Polycythemia and Hyperviscosity in Neonates -- Post-Discharge Nutrition in Preterm Infants -- Prenatal and Postnatal Inflammatory Mechanisms -- Primary Investigations in the Term and Preterm Newborn -- Problems of Discharge and Home Care of Newborns -- Pulmonary Air Leakage in Newborns -- Pulmonary Hemorrhage, Transient Tachypnea and Neonatal Pneumonia -- Quality of Neonatal Intensive Care and Outcome for High Risk Newborn Infants -- Rare Lung Diseases of Newborns -- Rare Surgical Emergencies of Newborns -- Recombinant G-CSF Treatment of Severe Chronic Neutropenia in Neonates and Infants -- Rehydration after Diarrhea in Newborns -- Respiratory Distress Syndrome: Predisposing Factors, Pathophysiology, and Diagnosis -- Resuscitation of the Newborn -- Retinopathy of Prematurity -- Risk Factors for Gestational Diseases -- Risk Management of Newborns -- Safety of Medications During Pregnancy and Breastfeeding: Infants of Drug-Addicted Mothers -- Surfactant Metabolism in Neonatal Lung Diseases -- Surgical Treatment in Newborns of Necrotizing Enterocolitis -- Surgical Treatment of Biliary Tract Malformations in Newborns -- The Fetus at Risk: Chorioamnionitis -- The Process of Decision-Making in Neonatology -- The Thrombotic Risk of the Newborn -- The Timing of Neonatal Brain Damage -- Toxoplasmosis in the Fetus and in the Newborn -- Treatment of Hyperbilirubinemia in Newborns -- Treatment of Respiratory Failure in Newborn: Mechanical Ventilation -- Vaccinations and Neonatal Immunity.
Format
e-Book
Location
Online
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The Clinical Application of Homocysteine

https://libcat.nshealth.ca/en/permalink/provcat42569
Seema Bhargava. --Singapore: Springer , c2018.
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This book helps clinicians to optimally and appropriately utilize homocysteine levels in the diagnosis, prediction and management of and research into vascular disease and many other conditions. It also familiarizes readers with the pathophysiology and clinical implications of hyperhomocysteinemia. Laboratory investigations are gaining importance in the diagnosis and prognosis of patients, and as such, scientists and laboratorians are constantly attempting to identify new markers that will help…
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Author
Bhargava, Seema
Responsibility
Seema Bhargava
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xix, 96 p.) : 19 illus. in color
ISBN
9789811076329
9789811076312 (print ed.)
9789811076336 (print ed.)
Subjects (MeSH)
Homocysteine
Homocysteinemia
Specialty
Biochemistry
Cardiology
Abstract
This book helps clinicians to optimally and appropriately utilize homocysteine levels in the diagnosis, prediction and management of and research into vascular disease and many other conditions. It also familiarizes readers with the pathophysiology and clinical implications of hyperhomocysteinemia. Laboratory investigations are gaining importance in the diagnosis and prognosis of patients, and as such, scientists and laboratorians are constantly attempting to identify new markers that will help in earlier diagnosis and better prognostication of conditions with high morbidity and mortality, as well as high prevalence. According to the WHO, developing countries are home to 80% of patients with coronary artery disease (CAD) and stroke—conditions with a mortality second only to cancer. Intensive research in these areas has resulted in the identification of homocysteine (declared the 'marker of the millennium') and several new markers for the diagnosis and prediction of CAD and stroke. The book is a valuable resource for clinicians and consultants in practice, as well as for postgraduate and undergraduate students of medicine, biotechnology and biochemistry.
Contents
Part I: Homocysteine and Homocysteinemia -- 1. Introduction -- 2. Homocysteine: Discovery and Metabolism -- Part II: Clinical Implications of Homocysteinemia -- 3. Homocysteine in Occlusive Vascular Disease -- 4. Homocysteinemia and Hypertension -- 5. Homocysteinemia and Its Neurological Effects -- 6. Homocysteinemia in Nephrology Practice -- 7. Homocysteinemia and Oncology -- 8. Homocysteinemia and Otology -- 9. Homocysteinemia and Bones -- 10. Hydrogen Sulphide: The Body’s Inherent Defence Against Homocysteinemia -- 11. Homocysteine and Epigenetics -- 12. J Food Fortification.
Format
e-Book
Location
Online
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Dermatology and Diabetes

https://libcat.nshealth.ca/en/permalink/provcat43343
Emilia Noemí Cohen Sabban, Félix Miguel Puchulu, Kenneth Cusi, editors. --Cham: Springer , c2018.
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This book reviews the dermatological manifestations of Diabetes Mellitus, including a broad spectrum of conditions since the dysfunction of the cutaneous barrier, going through cutaneous infections in diabetics, dermatoses associated to Diabetes and manifestations related to Diabetes treatment. Moreover, the book comprises the latest concepts regarding epidemiology, classification, diagnosis and treatment of Diabetes Mellitus, insulin resistance and metabolic syndrome, including useful tools fo…
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Other Authors
Cohen Sabban, Emilia Noemí
Puchulu, Félix Miguel
Cusi, Kenneth
Responsibility
Emilia Noemí Cohen Sabban, Félix Miguel Puchulu, Kenneth Cusi, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 305 p.) : 168 illus., 165 illus. in color
ISBN
9783319724751
9783319724744 (print ed.)
9783319724768 (print ed.)
Subjects (MeSH)
Diabetes Complications
Diabetes Mellitus - physiopathology
Skin Diseases
Skin Manifestations
Specialty
Dermatology
Diabetes Mellitus
Abstract
This book reviews the dermatological manifestations of Diabetes Mellitus, including a broad spectrum of conditions since the dysfunction of the cutaneous barrier, going through cutaneous infections in diabetics, dermatoses associated to Diabetes and manifestations related to Diabetes treatment. Moreover, the book comprises the latest concepts regarding epidemiology, classification, diagnosis and treatment of Diabetes Mellitus, insulin resistance and metabolic syndrome, including useful tools for the management of patients with diabetes. It explains why skin conditions have such a great impact on the quality of life of these patients, particularly the subset of patients with diabetic foot syndrome. Dermatology and Diabetes discusses all these dermatologic conditions and provides a roundup of the current guidelines in diabetic patients. Taking into account the critical differential diagnostic information and therapeutic options, the book is an important reference for clinical dermatologist and all health care professionals involved.
Contents
1. Epidemiology of Diabetes -- 2. Definition, Diagnosis and Classification of Diabetes Mellitus -- 3. Basic Concepts in Insulin Resistance and Diabetes Treatment -- 4. Introduction to Cutaneous Manifestations of Diabetes Mellitus -- 5. Cutaneous Barrier, Innate Immunity and Diabetes -- 6. Cutaneous Markers of Diabetes Mellitus -- 7. Thick Skin Syndrome -- 8. Insulin Resistance and Acanthosis Nigricans -- 9. Fungal Infections in Diabetics -- 10. Diagnosis and Treatment of Infectious Complications at Diabetic Foot -- 11. Dermatoses Most Frequently Related to Diabetes Mellitus -- 12. Cutaneous Manifestations Induced by Antidiabetic Treatment -- 13. Multidisciplinary Management of Wound Healing in Diabetics -- 14. Vascular and Neuropathic Foot -- 15. Diabetes, Non-Enzymatic Glycation, and Aging -- 16. Nail Disorders in Diabetics.
Format
e-Book
Location
Online
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Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA

https://libcat.nshealth.ca/en/permalink/provcat43365
Daniel S. Duick, Robert A. Levine, Mark A. Lupo, editors. (Fourth edition) --Cham: Springer , c2018.
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In this concise, gold-standard 4th edition book, the volume editors and authors synthesize the prior three editions and provide a comprehensive and expanded review on the latest in the diagnosis and management of thyroid nodules, as well as an update on parathyroid disease and non-endocrine lesions of the neck. This user-friendly edition again emphasizes a multidisciplinary approach to thyroid ultrasound and UGFNA, offering all the new information and subtleties clinicians must know in the appl…
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Other Authors
Duick, Daniel S.
Levine, Robert A.
Lupo, Mark A.
Responsibility
Daniel S. Duick, Robert A. Levine, Mark A. Lupo, editors
Edition
Fourth edition
Former Title
Thyroid ultrasound and ultrasound-guided FNA
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (xiv, 546 p.) : 330 illus., 220 illus. in color
ISBN
9783319672380
9783319672373 (print ed.)
9783319672397 (print ed.)
Subjects (MeSH)
Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods
Parathyroid Diseases - diagnosis
Thyroid Diseases - diagnosis
Specialty
Endocrinology
Ultrasonography
Notes
Preceded by: Thyroid ultrasound and ultrasound-guided FNA / H. Jack Baskin, Sr., Daniel S. Duick, Robert A. Levine, editors. 3rd ed. 2013.
Abstract
In this concise, gold-standard 4th edition book, the volume editors and authors synthesize the prior three editions and provide a comprehensive and expanded review on the latest in the diagnosis and management of thyroid nodules, as well as an update on parathyroid disease and non-endocrine lesions of the neck. This user-friendly edition again emphasizes a multidisciplinary approach to thyroid ultrasound and UGFNA, offering all the new information and subtleties clinicians must know in the application of this technique, now firmly established as a primary tool for diagnosing and managing thyroid disease. Developed by renowned experts in thyroid and parathyroid disease, the book covers not only thyroid and parathyroid disease, but also imaging of the salivary glands and other non-endocrine lesions of the neck. In this edition, the authors expand the chapters on both surgical and non-surgical management. Given the increased use of molecular markers in thyroid evaluation, an excellent chapter addresses this topic. Finally, as more endocrinologists and surgeons perform ultrasounds in their office practices, a chapter on authoring ultrasound reports is now included. Combining the collective wisdom of specialists who treat patients with thyroid nodules, thyroid cancer and parathyroid disease, Handbook of Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA, 4th Edition is an invaluable resource and will continue serving as the "go to" guide for surgeons, endocrinologists, fellows and residents.
Contents
History of Thyroid Ultrasound -- Thyroid Ultrasound Physics -- Doppler Ultrasound -- Normal Neck Anatomy and Method of Performing Ultrasound Examination -- Pediatric Ultrasound of the Neck -- Diffuse Thyroid Disease (DTD) and Thyroiditis -- Ultrasound of Thyroid Nodules -- Ultrasound and Mapping of Neck Lymph Nodes -- Ultrasonography of the Parathyroid Glands -- Surgical Trends in Ultrasound Applications for the Treatment of Thyroid Nodules, Thyroid Cancer, and Parathyroid Disease -- Ultrasound of Salivary Glands and the Non-endocrine Neck -- Ultrasound-Guided Fine-Needle Biopsy of Thyroid Nodules -- Laser and Radiofrequency Ablation Procedures -- Percutaneous Ethanol Injection (PEI) for Thyroid Cysts and Other Neck Lesions -- Ultrasound Elastography of Thyroid Nodules -- Authoring Quality Ultrasound Reports.
Format
e-Book
Location
Online
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Active Surveillance for Localized Prostate Cancer : A New Paradigm for Clinical Management

https://libcat.nshealth.ca/en/permalink/provcat43371
Laurence Klotz, editor. (Second edition) --Cham: Humana Press , c2018.
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Online
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the…
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Other Authors
Klotz, Laurence
Responsibility
Laurence Klotz, editor
Edition
Second edition
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2018
Physical Description
1 online resource (xii, 250 p.) : 39 illus., 27 illus. in color
Series Title
Current clinical urology
ISBN
9783319627106
9783319627090 (print ed.)
9783319627113 (print ed.)
9783319873756 (print ed.)
ISSN
2197-7194
Subjects (MeSH)
Disease Progression
Medical Overuse - prevention & control
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - therapy
Watchful Waiting
Specialty
Medical Oncology
Urology
Abstract
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
Contents
Cancer Overdiagnosis and Overtreatment -- Can We Screen and Still Reduce Overdiagnosis? -- The Role of Fear in Overdiagnosis and Overtreatment -- Ethical and Legal Considerations in Active Surveillance for Prostate Cancer -- Gleason 6 Tumors Should Still Be Labeled As Cancer -- Risk Based Selection for Active Surveillance -- Surveillance at the Margins: Management of High Volume Gleason 6, PSA>10, or Gleason 3+4 -- How Should Patients on Active Surveillance be Followed? -- Triggers for Intervention -- MR Imaging in Prostate Tumor Volume Assessment: How Accurate? -- Can MRI Replace Biopsy in Men on Surveillance? -- Tissue Based Markers for Risk Prediction -- International AS Registry: The Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance Initiative -- Better Informed Decision Making to Optimize Patient Selection -- How Does QOL Compare Between Surveillance and Active Treatment? -- The Potential Benefits of Diet and Physical Activity among Active Surveillance Patients with Low-Burden Prostate Cancer -- Is there a Role for Pharmacologic Manipulation to Prevent Progression in Men on Active Surveillance? The Role of 5-ARIs, Statins, and Metformin -- The Update of Active Surveillance around the World: Utilization and Outcomes -- Tissue Preservation: Active Surveillance and Focal Therapy as Complimentary Strategies -- The Economics of Active Surveillance for Prostate Cancer -- Research Questions in Active Surveillance.
Format
e-Book
Location
Online
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Quantification of Biophysical Parameters in Medical Imaging

https://libcat.nshealth.ca/en/permalink/provcat43378
Ingolf Sack, Tobias Schaeffter, editors. --Cham: Springer , c2018.
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Online
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative bioma…
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Other Authors
Sack, Ingolf
Schaeffter, Tobias
Responsibility
Ingolf Sack, Tobias Schaeffter, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (viii, 497 p.) : 178 illus., 130 illus. in color
ISBN
9783319659244
9783319659237 (print ed.)
9783319659251 (print ed.)
Subjects (MeSH)
Biophysical Phenomena
Diagnostic Imaging
Specialty
Diagnostic Imaging
Abstract
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.
Contents
1. Introduction: Medical Imaging for the Quantitative Measurement of Biophysical Parameters -- Part I. Biological and Physical Fundamentals -- 2. The Fundamentals of Transport in Living Tissues Quantified by Medical Imaging Technologies -- 3. Mathematical Modeling of Blood Flow in the Cardiovascular System -- 4. A Biphasic Poroelasticity Model for Soft Tissue -- 5. Physical Properties of Single Cells and Collective Behavior -- 6. The Extracellular Matrix as a Target for Biophysical and Molecular Magnetic Resonance Imaging -- Part II. Medical Imaging Technologies -- 7. Mathematical Methods in Medical Image Processing -- 8. Acceleration Strategies for Data Sampling in MRI -- 9. 4D Flow MRI -- 10. CEST MRI -- 11. Innovative PET and SPECT Tracers -- 12. Methods and Approaches in Ultrasound Elastography -- 13. Photoacoustic Imaging: Principles and Applications -- 14. Fundamentals of X-Ray Computed Tomography: Acquisition and Reconstruction -- Part III. Applications -- 15. Quantification of Myocardial Effective Transverse Relaxation Time with Magnetic Resonance at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology -- 16. Extracellular Matrix-Specific Molecular MR Imaging Probes for the Assessment of Aortic Aneurysms -- 17. Diffusion-Based MRI: Imaging Basics and Clinical Applications -- 18. Quantification of Functional Heterogeneities in Tumors by PET Imaging -- 19. Tumor Characterization by Ultrasound Elastography and Contrast-Enhanced Ultrasound -- 20. Sensitivity of Tissue Shear Stiffness to Pressure and Perfusion in Health and Disease -- 21. Radionuclide Imaging of Cerebral Blood Flow -- 22. Cardiac Perfusion MRI -- 23. Myocardial Perfusion Assessment by 3D and 4D Computed Tomography.
Format
e-Book
Location
Online
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Nutrition and Diet in Maternal Diabetes : An Evidence-Based Approach

https://libcat.nshealth.ca/en/permalink/provcat43383
Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, editors. --Cham: Humana Press , c2018.
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This comprehensive volume covers all aspects of nutrition in different scenarios of maternal diabetes, including the Type 1 or Type 2 diabetic mother, gestational diabetes, and postpartum diabetes. The volumes offer a comprehensive, yet thorough, overview of the subject, from the prevalence, risk factors, and insulin requirements of the mother; to possible outcomes and effects on the infant; to dietary advice in general and specific scenarios; and information on macro and micronutrient suppleme…
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Other Authors
Rajendram, Rajkumar
Preedy, Victor R.
Patel, Vinood B.
Responsibility
Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2018
Physical Description
1 online resource (xxxvi, 514 p.) : 66 illus., 44 illus. in color
Series
Nutrition and Health
Series Title
Nutrition and health (Totowa, N.J.)
ISBN
9783319564401
9783319564388 (print ed.)
9783319564395 (print ed.)
9783319859125 (print ed.)
Subjects (MeSH)
Diabetes, Gestational - diet therapy
Maternal Nutritional Physiological Phenomena
Specialty
Diabetes Mellitus
Nutritional Sciences
Perinatology
Abstract
This comprehensive volume covers all aspects of nutrition in different scenarios of maternal diabetes, including the Type 1 or Type 2 diabetic mother, gestational diabetes, and postpartum diabetes. The volumes offer a comprehensive, yet thorough, overview of the subject, from the prevalence, risk factors, and insulin requirements of the mother; to possible outcomes and effects on the infant; to dietary advice in general and specific scenarios; and information on macro and micronutrient supplements. There is also a special section on international perspectives on maternal diabetes, with ten chapters that each focus on a different country. Nutrition and Diet in Maternal Diabetes: An Evidence-Based Approach offers an overview of the Type 1 and type 2 diabetic mother, maternal and offspring aspects of gestation diabetes, and breastfeeding and maternal gestational diabetes.
Contents
Part I: Definitions, Characterization and Diagnosis -- Global Estimates of Hyperglycaemia in Pregnancy: Determinants and Trends -- Diagnosis of Gestational Diabetes -- Evaluation of Glycemic Control Indexes During Pregnancy: The Role of HbAlc, Glycated Albumin, and Fructosamine -- Mental Health and Diabetes During Pregnancy: Is is Chicken or Egg? -- Part II: The Type I Diabetic Mother -- Maternal Overweight and Obesity in Pregnancies Complicated by Type 1 Diabetes -- Glycemic Control and Insulin in Type 1 Diabetic Pregnancies -- Part III: Global Findings in Gestational Diabetes -- Maternal Diabetes in Pregnancy: Iran Perspectives -- 25-Hydroxyvitamin D and its Impact on Pregnancy Outcomes and Gestational Diabetes in China -- Diagnosis of Gestational Diabetes Mellitus: Italian Perspectives on Risk Factor Based Screening -- Part IV: Genetic and Molecular Factors Associated with Maternal Gestational Diabetes -- Metabolic Fingerprints of Gestational Mellitus -- Genetic and Epidemiological Indications for Adiponectin Gene Dysregulation in Gestational Mellitus -- The Retinol Binding Protein-4 (RBP4) Gene and Gestational Diabetes -- Biomarkers of Metabolic and Cardiovascular Risk in Gestational Diabetes -- Fish Oil and Cardiac Akt/mTOR-mediated Insulin Resistance in Infants with Maternal Diabetes -- Part V: Pre-existing Conditions and Gestational Diabetes Risk -- Hypertensive Disorders of Pregnancy in Gestational Diabetes -- Links between Polycystic Ovary Syndrome and Gestational Diabetes -- Bariatric Surgery and its Impact on Gestational Diabetes -- Part VI: Dietary Interventions and Exercise -- Myo-inositol Supplementation in Gestational Diabetes -- Treatments with Low Glycaemic Index Diets in Gestational Diabetes -- Low-carbohydrate Diet for the Treatment of Gestational Diabetes Mellitus -- Using the Good Metabolome to Understand the Relationship between Maternal Diet and Gestational Diabetes -- Probiotics in the Prevention of Gestational Diabetes Mellitus -- The Role of Exercise in the Management of Gestational Diabetes Mellitus -- Part VII: Postpartum Effects of Gestational Diabetes -- Postpartum Glucose Intolerance in Gestational Diabetes -- Diet after Gestational Diabetes (GDM) -- Postpartum Oxidative Stress Markers in Woman with Previous Gestational Diabetes in Relation to Vascular Damage -- Neurodevelopmental Outcome in Offspring Born Following Gestational Diabetes -- Part VIII: Breast Feeding and Maternal Hyperglycemia -- Breastfeeding after Diabetes in Pregnancy: Thailand Perspectives -- Gestational Diabetes and Peptides in Breast Milk -- Dietary Advice and Glycemic Control in Woman with Type 1 Diabetes During Preconception Counselling, Pregnancy and Breastfeeding -- Part IX: Specific Dietary Components and Weight Gain -- Excessive Gestational Weight Gain and Pregnancy Outcomes in Gestational and Pre-gestational Diabetes -- Diet and Carbohydrate Food Knowledge in Gestational Diabetes: Challenges and Opportunities for Lifestyle Interventions -- Higher-complex Carbohydrate Diets in Gestational Diabetes -- Polyunsaturated Fatty Acids and Gestational Diabetes -- Folic Acid and Gestational Diabetes: Foundations for Further Studies -- Iron and Oxidative Stress in Gestational Diabetes -- Part X: Recommended Resources on Maternal Diabetes.
Format
e-Book
Location
Online
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Genitourinary Cancers

https://libcat.nshealth.ca/en/permalink/provcat42703
Siamak Daneshmand, Kevin G. Chan, editors. --Cham: Springer , c2018.
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Online
This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techni…
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Other Authors
Daneshmand, Siamak
Chan, Kevin G.
Responsibility
Siamak Daneshmand, Kevin G. Chan, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2018
Physical Description
1 online resource (vi, 308 p.) : 39 illus., 38 illus. in color
Series Vol.
175
Series Title
Cancer treatment and research
ISBN
9783319933399
9783319933382 (print ed.)
9783319933405 (print ed.)
ISSN
0927-3042
Subjects (MeSH)
Urogenital Neoplasms - diagnosis
Urogenital Neoplasms - genetics
Urogenital Neoplasms - therapy
Specialty
Medical Oncology
Urology
Abstract
This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.
Contents
New imaging techniques in prostate cancer -- Targeted ablative therapies for prostate cancer -- Prostate cancer markers -- Prognostic value of CTC's in urologic cancers -- Management of small renal masses -- Advances in the treatment of metastatic renal cell carcinoma -- Imaging in urologic cancers -- Molecular prognostication in bladder cancer -- Early cystectomy for high risk non-muscle invasive disease -- Care-coordination pathway after radical cystectomy -- Current role of checkpoint inhibitors in urologic cancers -- The Cancer Genome Atlas Project -- Prognostic models in germ cell tumors -- Modern management of testicular cancer.
Format
e-Book
Location
Online
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