Chronic Lymphocytic Leukemia
https://libcat.nshealth.ca/en/permalink/provcat44187
Michael Hallek, Barbara Eichhorst, Daniel Catovsky, editors.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in …
- Available Online
- View e-Book
- Other Authors
- Hallek, Michael
- Eichhorst, Barbara
- Catovsky, Daniel
- Responsibility
- Michael Hallek, Barbara Eichhorst, Daniel Catovsky, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (vi, 179 p.) : 23 illus., 19 illus. in color
- Series
- Hematologic Malignancies
- Series Title
- Hematologic malignancies (Series)
- ISBN
- 9783030113926
- 9783030113919 (Print ed.)
- 9783030113933 (Print ed.)
- ISSN
- 2197-9766
- Subjects (MeSH)
- Leukemia, Lymphocytic, Chronic, B-Cell
- Specialty
- Hematology
- Medical Oncology
- Abstract
- This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.
- Contents
- Part I. Pathophysiology -- 1. Chronic Lymphocytic Leukemia: Who, How, and Where? -- Part II. Diagnostics -- 2. Laboratory Diagnosis of Chronic Lymphocytic Leukaemia -- Part III. Clinical Presentation -- 3. The Clinical Presentation of CLL -- Part IV. Prognostic Markers -- 4. Prognostic Markers -- Part V. Treatment -- 5. Guidelines for Diagnosis, Indications for Treatment, Response Assessment, and Supportive Management of Chronic Lymphocytic Leukemia: The 2018 Update -- 6. Initial Therapy of Chronic Lymphocytic Leukemia -- 7. CLL with Del (17p)/TP53 Mutation -- 8. Treatment of Relapsed and Refractory Chronic Lymphocytic Leukemia -- Part VI. Follow-up and Complications -- 9. Autoimmune Cytopenia in Chronic Lymphocytic Leukemia -- 10. Richter Syndrome -- Part VII. Related Entities -- 11. Prolymphocytic Leukaemia -- 12. Large Granular Lymphocyte Leukemia.
- Format
- e-Book
- Location
- Online
Molecular Diagnostics in Cancer Patients
https://libcat.nshealth.ca/en/permalink/provcat44270
Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services…
- Available Online
- View e-Book
- Other Authors
- Shukla, Kamla Kant
- Sharma, Praveen
- Misra, Sanjeev
- Responsibility
- Kamla Kant Shukla, Praveen Sharma, Sanjeev Misra, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 341 p.) : 45 illus., 43 illus. in color
- ISBN
- 9789811358777
- 9789811358760 (Print ed.)
- 9789811358784 (Print ed.)
- Subjects (MeSH)
- Biomarkers, Tumor
- Molecular Diagnostic Techniques
- Neoplasms - diagnosis
- Pharmacogenetics
- Specialty
- Medical Oncology
- Molecular Medicine
- Abstract
- This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
- Contents
- 1. Recent Advances in Molecular Diagnostic Approaches for Cancer -- 2. Molecular Diagnosis of Gall Bladder Cancer -- 3. Molecular Diagnostics for Lung Cancer -- 4. Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors -- 5. Molecular Diagnostics in Melanoma: An Update -- 6. Molecular Diagnostics in Breast Cancer -- 7. Molecular Diagnostics in Non-Hodgkin Lymphoma -- 8. Molecular Diagnosis of Cervical Cancer -- 9. Molecular Diagnostics in Colorectal Cancer -- 10. Molecular Diagnostics in Pancreatic Cancer -- 11. Molecular Diagnostics in Head and Neck Squamous Cell Carcinoma -- 12. Molecular Diagnostic in Prostate Cancer -- 13. Molecular Diagnostics in Renal Cancer -- 14. Molecular Biomarkers and Urinary Bladder Cancer (UBC) -- 15. Molecular Pathway and Fluorescence In Situ Hybridization Testing of ERBB2 (HER2) Gene Amplification in Invasive Ductal Carcinoma of Breast -- 16. Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research -- 17. Molecular Diagnostics in Liver Cancer -- 18. Molecular Diagnosis of Uterine Cancer -- 19. Molecular Diagnosis in Ovarian Carcinoma.
- Format
- e-Book
- Location
- Online
GI Surgery Annual. Volume 25
https://libcat.nshealth.ca/en/permalink/provcat44314
T. K. Chattopadhyay, editor-in-chief ; Peush Sahni, Sujoy Pal, editors.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new deve…
- Available Online
- View e-Book
- Other Authors
- Chattopadhyay, T.K.
- Sahni, Peush
- Pal, Sujoy
- Responsibility
- T. K. Chattopadhyay, editor-in-chief ; Peush Sahni, Sujoy Pal, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (ix, 269 p.) : 34 illus., 26 illus. in color
- Series
- GI Surgery Annual
- Series Vol.
- 25
- Series Title
- GI surgery annual
- ISBN
- 9789811332272
- 9789811332265 (Print ed.)
- 9789811332289 (Print ed.)
- ISSN
- 2367-3435
- Subjects (MeSH)
- Digestive System Diseases
- Digestive System Surgical Procedures
- Gastrointestinal Diseases - surgery
- Abstract
- The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new developments in the field. The GI Surgery Annual 25th Volume provides up-to-date information on current hot topics.
- Contents
- 1. Esophagogastric Junction (EGJ) Carcinoma: An Updated Review -- 2. Superior Mesenteric Artery Syndrome -- 3. Biologics and Inflammatory Bowel Disease -- 4. New Surgical Modalities in the Management of Rectal Cancer -- 5. Tumor Markers in GI and HPB Cancers -- 6. IgG4 HPB Disease -- 7. ERCP-Induced Perforations -- 8. Bridging Therapy for HCC -- 9. Adjuncts to Liver Resection -- 10. Advances in Gastrointestinal Surgery.
- Format
- e-Book
- Location
- Online
Preventive Oncology for the Gynecologist
https://libcat.nshealth.ca/en/permalink/provcat44349
Sumita Mehta, Anshuja Singla, editors.
--Singapore:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book explores all aspects of preventive oncology of the female genital tract and provides readers with detailed insights on the topic. Preventive oncology has long been recognized as a pressing need, though formally few steps have been taken to actively promote it. The book’s respective chapters holistically cover the concept of cancer prevention for the female genital tract & breast. In addition, it explains the evidence-based value of each screening modality, and the rationale behind the…
- Available Online
- View e-Book
- Other Authors
- Mehta, Sumita
- Singla, Anshuja
- Responsibility
- Sumita Mehta, Anshuja Singla, editors
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xviii, 450 p.) : 151 illus., 131 illus. in color
- ISBN
- 9789811334382
- 9789811334375 (Print ed.)
- 9789811334399 (Print ed.)
- Subjects (MeSH)
- Genital Neoplasms, Female - diagnosis
- Genital Neoplasms, Female - prevention & control
- Women's Health
- Specialty
- Gynecology
- Medical Oncology
- Abstract
- This book explores all aspects of preventive oncology of the female genital tract and provides readers with detailed insights on the topic. Preventive oncology has long been recognized as a pressing need, though formally few steps have been taken to actively promote it. The book’s respective chapters holistically cover the concept of cancer prevention for the female genital tract & breast. In addition, it explains the evidence-based value of each screening modality, and the rationale behind the recommended screening guidelines. In closing, the book highlights a wealth of recent evidence-based literature, making it a highly informative resource that will significantly broaden readers’ understanding of preventive oncology.
- Contents
- Part I. Endometrium -- 1. Endometrial Carcinoma: Epidemiology and Risk Factors -- 2. Role of Screening Modalities in Endometrial Cancer Detection -- 3. Endometrial Hyperplasia: Diagnosis and Management -- 4. Hereditary Endometrial and Ovarian Cancers -- 5. Chemoprevention for Endometrial Cancers -- Part II. Cervix -- 6 .Cervical Squamous Intraepithelial Lesions: A Pathologist’s Perspective -- 7. Cytology and HPV Testing in Primary Cervical Cancer Screening -- 8. Management of Abnormal Cytology -- 9. HPV Infection: Pathogenesis and Detection -- 10. Biomarkers for the Early Detection of Cervical Cancer -- 11. Colposcopic Principles and Tissue Basis -- 12. Colposcopic Features of Cervical Intraepithelial Lesions -- 13. Cervical Cancer Screening in Pregnancy -- 14. Cervical Cancer Screening in Low-Resource Settings -- 15. Ablative Methods for Treatment of Intraepithelial Lesions -- 16. Management of High-Grade Lesions -- Part III. Ovary -- 17. Epidemiology and Risk Factors for Ovarian Cancer -- 18. Role of Tumor Markers -- 19. Screening for Ovarian Cancer -- 20. Prevention of Ovarian Cancer -- Part IV. Vulva and Vagina -- 21. Risk Factors and Classification of Vulvar Intraepithelial Lesions -- 22. Detection of Precancerous Lesions of the Vulva -- 23. Management of Vulvar Intraepithelial Neoplasia -- 24. Vaginal Cancer: Epidemiology and Risk Factors -- 25. Vaginal Intraepithelial Neoplasia (VaIN): Diagnosis and Management -- Part V. Breast -- 26. Epidemiology of Breast Cancer: Current Figures and Trends -- 27. Breast Cancer: Role of Imaging -- 28. Breast Cancer Screening Modalities -- 29. Breast Cancer Risk Assessment and Genetic Testing -- 30. Preinvasive Breast Lesions: Detection and Management -- Part VI. Newer Concepts -- 31. Contribution of the Gut and Vaginal Microbiomes to Gynecological Cancers -- 32. HPV Infection and Gynecological Cancers -- 33. Advances in -- 34. Update on HPV Vaccination.
- Format
- e-Book
- Location
- Online
Biomarkers in Cancer Therapy : Liquid Biopsy Comes of Age
https://libcat.nshealth.ca/en/permalink/provcat44460
Hideaki Shimada, editor.
--Singapore:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which serve as the basis for exploring key research questions for future clinical trials in the book’s second half. The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is…
- Available Online
- View e-Book
- Other Authors
- Shimada, Hideaki
- Responsibility
- Hideaki Shimada, editor
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 157 p.) : 22 illus., 17 illus. in color
- ISBN
- 9789811372957
- 9789811372940 (Print ed.)
- 9789811372964 (Print ed.)
- 9789811372971 (Print ed.)
- Subjects (MeSH)
- Biomarkers
- Liquid Biopsy
- Neoplasms - diagnosis
- Abstract
- This book sheds new light on research into liquid biopsy biomarkers for cancer screening. The chapters in the first half address exosomes, circulating cell-free DNA and autoantibodies, and main solid cancers, along with companion biomarkers – all of which serve as the basis for exploring key research questions for future clinical trials in the book’s second half. The study of biomarkers has evolved rapidly thanks to advances in precision medicine. While conventional cancer biomarker research is focused on proteomics or gene analysis of resected tissue, diagnostic markers have since become significant in terms of gauging the effectiveness of molecularly targeted drugs or the likelihood of a favorable prognosis. In addition, conventional treatment strategy, which draws on archives of resected tissue samples, is now gradually being replaced by monitoring with the use of liquid biopsy, which is poised to become the new mainstream in molecular targeting therapy. The contributing authors discuss in detail biomarkers, molecular targets for treatment, monitoring markers to evaluate treatment responses, prognostic markers, and screening and early diagnosis. Accordingly, this excellent collection of texts will benefit not only oncologists, but also medical and biological researchers and pharmaceutical scientists involved in the latest cancer research.
- Contents
- Part I. Various Strategies to Detect Cancer -- 1. Liquid Biopsy Diagnostics Using Extracellular Vesicles -- 2. Cell-Free DNA -- 3. Autoantibody in Cancer -- 4. Serum Angiogenic Factors as Cancer Biomarkers -- 5. Biomarkers of Cancer Stem Cells in Cancer Therapy -- Part II. Biomarkers for Individual Cancers -- 6. Specifics 1: Head and Neck Cancer and Esophageal Cancer -- 7. Biomarkers in Gastric Cancer -- 8. Liquid Biopsy in Hepatocellular Carcinoma -- 9. Biomarkers of Pancreatic Cancer -- 10. Biomarkers of Lung Cancer: Liquid Biopsy Comes of Age -- 11. Biomarkers for Breast Cancer Treatment -- 12. Biomarkers of Prostate Cancer -- 13. Biomarkers of Gynecological Cancers -- 14. Biomarkers of Malignant Pleural Mesothelioma.
- Format
- e-Book
- Location
- Online
Biomarkers in Inflammatory Bowel Diseases
https://libcat.nshealth.ca/en/permalink/provcat44481
Nik Sheng Ding, Peter De Cruz, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, p…
- Available Online
- View e-Book
- Other Authors
- Sheng Ding, Nik
- De Cruz, Peter
- Responsibility
- Nik Sheng Ding, Peter De Cruz, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xvii, 365 p.) : 35 illus., 30 illus. in color
- ISBN
- 9783030114466
- 9783030114459 (Print ed.)
- 9783030114473 (Print ed.)
- Subjects (MeSH)
- Biomarkers
- Inflammatory Bowel Diseases - diagnosis
- Abstract
- This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
- Contents
- 1. Introduction -- Part I. Background to Biomarkers -- 2. Clinical Risk Factors: Lessons from Epidemiology -- 3. Disease Modification in Crohn’s Disease -- 4. Personalized Medicine - Dream or Reality? -- 5. Clinical Trial Design to Facilitate Biomarker Discovery -- Part II. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Crohn’s Disease -- 6. Luminal Crohn’s Disease -- 7. Fibrosis and Stricturing Disease in Crohn’s Disease -- 8. Postoperative Crohn’s Disease -- 9. Perianal Crohn’s Disease -- Part III. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Ulcerative Colitis -- 10. Biomarkers in Acute Severe Ulcerative Colitis -- 11. Chronic Active Ulcerative Colitis -- 12. Refractory Proctitis -- 13. UC Surveillance -- 14. The Role of Biomarkers in the Ileal Anal Pouch -- Part IV. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Specialised Scenarios -- 15. Extra-intestinal Manifestations in Inflammatory Bowel Disease: Diagnosis and Management -- 16. Primary Sclerosing Cholangitis Overlapping with IBD -- 17. Pregnancy and IBD -- 18. Nutrition in IBD -- 19. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Thiopurines -- 20. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Biologics -- 21. Drug Toxicity: Personalising IBD Therapeutics–The Use of Genetic Biomarkers to Reduce Drug Toxicity -- 22. Biomarkers for Remote Monitoring -- Part V. Scientific Platforms for Biomarker Discovery -- 23. Exposome and Diet -- 24. The Microbiome in IBD -- 25. Metabolic Profiling in IBD -- 26. Innate and Adaptive Immunology -- 27. Genetic and Genomic Markers for Prognostication -- 28. Risk Alleles for Drug Targets: Genomic Markers of Drug Response -- Part VI. Conclusion -- 29. Big Data Meets Real World! The Use of Clinical Informatics in Biomarker Research -- 30. Bringing It Altogether: A Systems Biology Approach to Biomarkers in Inflammatory Bowel Disease.
- Format
- e-Book
- Location
- Online
Postmenopausal Diseases and Disorders
https://libcat.nshealth.ca/en/permalink/provcat44510
edited by Faustino R. Pérez-López.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes th…
- Available Online
- View e-Book
- Other Authors
- Pérez-López, Faustino R.
- Responsibility
- edited by Faustino R. Pérez-López
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (ix, 484 p.) : 45 illus., 40 illus. in color
- ISBN
- 9783030139360
- 9783030139353 (Print ed.)
- 9783030139377 (Print ed.)
- 9783030139384 (Print ed.)
- Subjects (MeSH)
- Postmenopause - physiology
- Women's Health
- Specialty
- Gynecology
- Women's Health
- Abstract
- Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes the development of quick and easy-to-use assessment tools and predictive markers of age-related co-morbidities. As such, the book is a valuable resource for researchers and clinicians alike.
- Contents
- 1. Assisted Reproductive Technology in Peri- and Postmenopausal Women -- 2. Turner Syndrome: Primary Amenorrhea from Adolescence to Ageing -- 3. Premature Ovarian Insufficiency -- 4. Human Papilloma Virus Infection and Cancer Risk in Peri- and postmenopausal Women -- 5. Risk and Protective Factors for Sporadic Ovarian and Fallopian Tube Cancer in Postmenopausal Women -- 6. Vulvar Dermatoses and Menopause -- 7. Bladder Pain Syndrome/Interstitial Cystitis -- 8. Overactive Bladder -- 9. Management of Female Stress Urinary Incontinence -- 10. Screening and Management of Female Sexual Dysfunction During the Second Half of Life -- 11. Current Treatment Modalities for the Genitourinary Syndrome of Menopause -- 12. Laser Treatment for Vulvovaginal Atrophy -- 13. Laser Treatments in Female Urinary Incontinence -- 14. Metabolic Syndrome and Excessive Body Weight in Peri- and Postmenopausal Women -- 15. Metabolic Syndrome and Atherosclerosis in Non-diabetic Postmenopausal Women -- 16. Polycystic Ovary Syndrome related Risks in Postmenopausal Women -- 17. Sleep and Sleep Disturbances in Climacteric Women -- 18. Impact of Menopause on Brain Functions -- 19. Vasomotor Symptoms: Clinical Management -- 20. Vasomotor Symptoms, Metabolic Syndrome and Cardiovascular Risks -- 21. A Woman's Heart Needs Her Hormones -- 22. Menopause Hormone Therapy to Prevent Chronic Conditions -- 23. Selective Estrogen Receptor Modulators (SERMs): State of the Art -- 24. Management of Osteoporosis in Postmenopausal Women -- 25. Anabolic Agents for the Treatment of Postmenopausal Osteoporosis -- 26. The Links Between Osteoporosis and Sarcopenia in Women -- 27. Female Sarcopenic Obesity -- 28. Cognitive Decline in Women: The Zarademp Study -- 29. Managing Menopause and Post-reproductive Health: Beyond Hormones and Medicines -- 30. Effect of Exercise on Menopausal Prevalent Conditions.
- Format
- e-Book
- Location
- Online
Tumor Angiogenesis : A Key Target for Cancer Therapy
https://libcat.nshealth.ca/en/permalink/provcat44567
edited by Dieter Marmé.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not a…
- Available Online
- View e-Book
- Other Authors
- Marmé, Dieter
- Responsibility
- edited by Dieter Marmé
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource
- Series Title
- Springer reference
- ISBN
- 9783319312156
- Subjects (MeSH)
- Angiogenesis Inhibitors - therapeutic use
- Neovascularization, Pathologic - physiology
- Neovascularization, Pathologic - therapy
- Neoplasms - blood supply
- Neoplasms - therapy
- Specialty
- Medical Oncology
- Molecular Medicine
- Notes
- "Living reference work."
- Abstract
- Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.
- Contents
- Angiopoietins and TIE Receptors in Lymphangiogenesis and Tumor Metastasis -- Anti-Angiogenic Cancer Therapy: Development of Resistance -- Anti-Angiogenic Targeting in Metastatic Colorectal Cancer Therapy -- Anti-Angiogenic Targets: Angiopoietin and Angiopoietin-Receptors -- Anti-Angiogenics and Radiation Therapy -- Anti-Angiogenics in Gastroesophageal Cancer -- Anti-Angiogenics in Hepatocellular Cancer Therapy -- Anti-angiogenics in Kidney Cancer Therapy -- Anti-Angiogenics in Pancreatic Cancer Therapy -- Antiangiogenics in Brain Metastases: Perspectives and Experiences -- Benefits and Pitfalls of Tumor Vessel Normalization -- Biomarkers for Anti-angiogenic Therapy -- Combination of Antiangiogenics and Other Targeted Therapies -- Controlling Vascular Permeability: How Does It Work and What Is the Impact on Normal and Pathological Angiogenesis -- Cytotoxics and Anti-Angiogenics: Metronomic Therapies -- Endothelial Cell-Cell Junctions in Tumor Angiogenesis -- Imaging Tumor Angiogenesis -- Inhibition of Tumor Angiogenesis in GIST Therapy -- Inhibition of Tumor Angiogenesis in the Treatment of Lung Cancer -- Mechanisms of Anti-Angiogenic Therapy -- Mechanisms of Tumor Angiogenesis -- Pathology of Tumor Angiogenesis -- Significance and Molecular Regulation of Lymphangiogenesis in Cancer -- The Impact of Endothelial Transcription Factors in Sprouting Angiogenesis -- The Implication of Antiangiogenic Treatment of Malignancies on Human Metabolism -- The Role of the VEGF Signaling Pathway in Tumor Angiogenesis -- The Role of VEGF in Controlling Vascular Permeability -- The Value of Anti-Angiogenics in Bladder Cancer Therapy -- The Value of Anti-Angiogenics in Cervical Cancer Therapy -- The Value of Anti-Angiogenics in Head and Neck Cancer Therapy -- The Value of Anti-Angiogenics in Multiple Myeloma Therapy -- The Value of Anti-Angiogenics in Ovarian Cancer Therapy -- The Value of Anti-Angiogenics in Primary Brain Tumor Therapy -- The Value of Anti-Angiogenics in Prostate Cancer Therapy -- The Value of Anti-Angiogenics in Soft Tissue Sarcoma Therapy -- The Value of Antiangiogenics in Breast Cancer Therapy.
- Format
- e-Book
- Location
- Online
Cutaneous Melanoma
https://libcat.nshealth.ca/en/permalink/provcat44575
edited by Charles Balch ... [and 9 others].
([6th ed.])
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors…
- Available Online
- View e-Book
- Other Authors
- Balch, Charles
- Responsibility
- edited by Charles Balch ... [and 9 others]
- Edition
- [6th ed.]
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource
- Series Title
- Springer reference
- ISBN
- 9783319460291
- Subjects (MeSH)
- Melanoma
- Specialty
- Dermatology
- Medical Oncology
- Notes
- "Living reference work."
- Abstract
- Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
- Contents
- A History of Melanoma: From Hunter to Morton -- Acquired Precursor Lesions and Phenotypic Markers of Increased Risk for Cutaneous Melanoma -- Acral Lentiginous Melanoma -- Adjuvant Systemic Therapy for High-Risk Melanoma Patients -- Axillary and Epitrochlear Lymph Node Dissection for Melanoma -- Biology of Melanocytes and Primary Melanoma -- Biomarkers for Melanoma -- Biopsy of Suspected Melanoma -- Biopsy of the Sentinel Lymph Node -- Cellular Therapy for Melanoma -- Checkpoint Inhibitors in the Treatment of Metastatic Melanoma -- Classification and Histopathology of Melanoma -- Clinical Epidemiology of Melanoma -- Clinical Genetics and Risk Assessment of Melanoma -- Clinical Presentations of Melanoma -- Cytokines (IL-2, IFN GM-CSF etc) Melanoma -- Dermatological Complications of Systemic Therapies for Melanoma -- Dermoscopy/Confocal Microscopy -- Diagnosis of Stage IV Melanoma -- Evolving Role of Chemotherapy-Based Treatment of Metastatic Melanoma -- Hyperthermic Regional Perfusion for Melanoma of the Limbs -- Immunology of Melanoma -- Inguinofemoral, Iliac/Obturator, and Popliteal Lymphadenectomy for Melanoma -- Isolated Limb Infusion for Melanoma -- Lentigo Maligna Melanoma -- Local and Recurrent Regional Metastases of Melanoma -- Local Melanoma Recurrence, Satellitosis, and In-transit Metastasis: Incidence, Outcomes, and Selection of Treatment Options -- Lymphoscintigraphy in Patients with Melanoma -- Managing Checkpoint Inhibitor Symptoms and Toxicity -- Melanoma Brain Metastases: Unique Biology and Implications for Systemic Therapy -- Melanoma Prevention and Screening -- Melanoma Vaccines -- Models for Predicting Melanoma Outcome -- Molecular Epidemiology of Melanoma -- Molecular Pathology and Genomics of Melanoma -- Molecularly Targeted Therapy for Patients with BRAF Wild-Type Melanoma -- Mucosal Melanoma -- Neck Dissection and Parotidectomy for Melanoma -- Neoadjuvant Systemic Therapy for High-Risk Melanoma Patients -- Novel Immunotherapies and Novel Combinations of Immunotherapy -- Pregnancy and the Use of Hormones in Melanoma Patients -- Radiotherapy for Distant Metastases -- Radiotherapy for Primary and Regional Melanoma -- Sequencing and Combinations of Molecularly Targeted and Immunotherapy for BRAF-Mutant Melanoma -- Surveillance and Follow-Up of Melanoma Patients -- Systemic Therapy for Mucosal, Acral and Uveal Melanoma -- Targeted Therapies for BRAF-Mutant Metastatic Melanoma -- Treatment of Primary Melanomas.
- Format
- e-Book
- Location
- Online
Varicocele and Male Infertility : A Complete Guide
https://libcat.nshealth.ca/en/permalink/provcat44741
Sandro C Esteves, Chak-Lam Cho, Ahmad Majzoub, Ashok Agarwal, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventi…
- Available Online
- View e-Book
- Other Authors
- Esteves, Sandro C.
- Cho, Chak-Lam
- Majzoub, Ahmad
- Agarwal, Ashok
- Responsibility
- Sandro C Esteves, Chak-Lam Cho, Ahmad Majzoub, Ashok Agarwal, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xxvii, 638 p.) : 91 illus., 68 illus. in color
- ISBN
- 9783319791029
- 9783319791012 (Print ed.)
- 9783319791036 (Print ed.)
- Subjects (MeSH)
- Infertility, Male - etiology
- Infertility, Male - therapy
- Varicocele - complications
- Varicocele - diagnosis
- Varicocele - surgery
- Specialty
- Men's Health
- Reproductive Medicine
- Abstract
- This unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress-associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content. Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.
- Contents
- Part I: Varicocele Origin and Pathology -- Anatomic theories of varicocele origin -- Scrotal hyperthermia, hormonal disturbances, testicular hypoperfusion, and backflow of toxic metabolites in varicocele -- Genetics and epigenetics of varicocele pathophysiology -- Oxidative stress and varicocele pathophysiology -- Proteomic and metabolomic profile of semen and seminal plasma in varicocele -- Experimental varicocele -- Part II: Clinical Evaluation of Varicocele -- Epidemiology of varicocele in pediatric, adolescent and adult populations -- Association between varicocele and infertility -- Varicocele clinical diagnosis and grading -- Imaging and other diagnostic modalities in varicocele diagnosis -- Conventional semen analysis and specialized sperm function tests in patients with varicocele -- Endocrine testing and the association between varicocele and hypogonadism -- Varicocele and orchialgia -- Part III: Therapy of Varicocele -- The evolution and refinement of varicocele treatment: A historical perspective -- Medical therapy in varicocele-related infertility -- Macroscopic surgical techniques for varicocele repair -- Microscopic surgical techniques for varicocele repair -- Laparoscopic techniques for varicocele repair -- Interventional radiology for varicocele treatment -- Robotic assisted microsurgical varicocelectomy -- Effect of varicocele treatment on conventional semen analysis -- Effect of varicocele treatment on oxidative stress markers and sperm DNA fragmentation -- Effect of varicocele treatment on natural pregnancy outcome -- Effect of varicocele treatment on assisted reproductive technology (ART) pregnancy outcome -- Varicocele and azoospermia -- Prognostic factors for a favorable outcome after varicocele repair in adults with infertility -- Management of recurrent varicocele -- Cost-effectiveness analysis of varicocele repair and assisted reproductive technology -- Management of pediatric and adolescent varicocele -- Part IV: Controversies with Varicocele -- Is varicocele a bilateral disease? -- Why is subclinical varicocele considered a different entity? -- Why is it that not all men with varicocele are infertile? -- Is there a role for testicular biopsy in men with varicocele? -- Should bilateral varicocele repair be recommended in cases of a clinical varicocele and contralateral subclinical varicocele? -- Is there any role for intraoperative ultrasound during varicocele repair? -- Is there any role for indocyanine green angiography in testicular artery preservation during microsurgical subinguinal varicocelectomy? -- Should a varicocele be repaired before assisted reproductive technology treatment? -- Should a varicocele be repaired in non-infertile patients with hypogonadism? -- What should be the ideal control group in clinical trials investigating the role of varicocele and its treatment on fertility outcomes? -- Part V: Debate (Pro and Con) over Varicocele -- Should SDF testing be used in men with varicocele? -- Should varicocele be repaired before ART? -- Should varicocele be repaired in azoospermic infertile men? -- Should varicocele be managed surgically or radiographically? -- Part VI: Clinical Case Scenarios Involving Varicocele -- Grade 1 varicocele and borderline/normal conventional semen analysis -- Grades 2/3 varicocele and normal conventional semen analysis -- Clinical varicocele and severely abnormal semen analysis in a couple considering ART whose female partner is over 36 years old -- Asymptomatic male with left grade 3 varicocele and 2 children desiring vasectomy with low testosterone -- Symptomatic male with subclinical varicocele found on ultrasound evaluation -- Recurrent grade 2/3 varicocele after microsurgical varicocelectomy and abnormal semen parameters in a couple attempting conception for >3 years -- Grade 2/3 varicocele in a 15-year-old healthy boy with normal testis volume (and normal semen analysis) with a history of varicocele and infertility in his father -- Part VII: Clinical Practice Guidelines for Varicocele -- Adult varicocele diagnosis and treatment -- Pediatric and adolescent varicocele diagnosis and treatment -- Sperm DNA fragmentation testing and varicocele -- Grade of evidence on varicocele treatment -- A ‘Strengths-Weakness-Opportunities-Threats’ (SWOT) analysis of varicocele-related infertility and its diagnosis and management.
- Format
- e-Book
- Location
- Online
Adolescent Health and Wellbeing : Current Strategies and Future Trends
https://libcat.nshealth.ca/en/permalink/provcat44756
Alessandro Pingitore, Francesca Mastorci, Cristina Vassalle, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and t…
- Available Online
- View e-Book
- Other Authors
- Pingitore, Alessandro
- Mastorci, Francesca
- Vassalle, Cristina
- Responsibility
- Alessandro Pingitore, Francesca Mastorci, Cristina Vassalle, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xii, 352 p.) : 45 illus., 37 illus. in color
- ISBN
- 9783030258160
- 9783030258153 (Print ed.)
- 9783030258177 (Print ed.)
- 9783030258184 (Print ed.)
- Subjects (MeSH)
- Adolescent
- Health Promotion
- Preventive Medicine
- Social Determinants of Health
- Subjects (LCSH)
- Pediatrics
- Health promotion
- Primary care (Medicine)
- Medical policy
- Child psychiatry
- Specialty
- Adolescent Health
- Abstract
- This book presents a detailed and updated review of the widespread changes that take place during adolescence, adopting a preventive perspective that reflects physical, social, cognitive, and emotional changes. It addresses a broad range of aspects, including: the preventive programs and their systemic effects; the role of environment in influencing the healthy behaviors of adolescents and young adults; the use of e-Health technology in health and behavioral interventions for adolescents; and the clinical and prognostic implications of primordial prevention in healthy adolescents. All of these elements are subsequently reviewed using a multidimensional approach, in order to offer extensive information on the complex changes that characterize adolescents’ physiological, psychological, and neurobiological development. In addition, the book depicts the preventive strategies currently used in various social settings (school, family, sport club, health policies) aimed not only at reducing lifestyle risk behaviors, but also at improving resilience, happiness, social involvement, self-esteem, and sociability. This update is essential in the light of the fact that, to date, prevention has mainly been directed towards adolescents with physical or mental disorders rather than their healthy peers. As such, the book offers a valuable tool for pediatricians, child and adolescents psychiatrists, and for all professionals involved in Health Promotion and Disease Prevention.
- Contents
- Part I. Primordial Prevention: General Aspects - 1. Preventive Primordial Strategies: Times Are Changing -- 2. Fetal Programming of Adult Disease in a Translational Point of View -- 3. Physical Activity, Sedentary Behaviour and Mental Health in Young People: A Review of Reviews -- 4. Habits and Quality of Diet -- 5. Biochemical Markers in Primordial Prevention: Premises and Promises -- Part II. Adolescents’ Mental Health and Well-Being -- 6. Prenatal and Early Postnatal Influences on Neurodevelopment: The Role of Epigenetics -- 7. The Role of Environmental Enrichment on Neurodevelopment: Emotion Regulation in Adolescence as a Model Paradigm -- 8. Relationship Between Emotions, Sleep and Well-Being -- 9. Adolescents in the 21st Century: Back to Dialogue from Marked Lives vs Dreamed Lives -- Part III. Adolescence and the Social Determinants of Health -- 10. Adolescence and Social Determinants of Health: Family and Community -- 11. The Role of Well-Being in the School of Inclusion -- 12. Two-Faced Janus: The Role of Peers in Adolescence -- Part IV. The Digital Era in Adolescent’s Health and Well-Being -- 13. Adolescence Between Past and Future -- 14. e-Health Strategies -- 15. Images and Perspectives of Play for Children’s and Adolescents’ Well-being -- 16. New Perspectives for Multidisciplinary and Integrated Strategies of Adolescent Health and Well-being.
- Format
- e-Book
- Location
- Online
Immunohistochemistry in Tumor Diagnostics
https://libcat.nshealth.ca/en/permalink/provcat42539
Muin S.A. Tuffaha, Hans Guski, Glen Kristiansen.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics. Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunopro…
- Available Online
- View e-Book
- Author
- Tuffaha, Muin S.A
- Other Authors
- Guski, Hans
- Kristiansen, Glen
- Responsibility
- Muin S.A. Tuffaha, Hans Guski, Glen Kristiansen
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xii, 264 p.) : 139 illus. in color
- ISBN
- 9783319535777
- 9783319535760 (print ed.)
- 9783319535784 (print ed.)
- 9783319851884 (print ed.)
- Subjects (MeSH)
- Immunohistochemistry - methods
- Neoplasms - diagnosis
- Abstract
- This book offers a comprehensive yet concise overview of immunoprofile of tumors and antibodies used in contemporary surgical pathology, and provides diagnostic algorithms for approaching tumor diagnostics. Immunohistochemistry has become the most important ancillary technique in diagnostic pathology in the last 20 years, and unlike most books on tumor diagnostics, this volume discusses in details immunohistochemical biomarkers, diagnostic approaches and their pitfalls, as well as the immunoprofile of common tumors throughout all systems of human body. With numerous color figures and detailed flowcharts, it appeals to all pathologists be they young residents in training who want a brief introduction to this technique, or specialists in need of a reliable and comprehensive reference resource in tumors diagnostics.
- Contents
- Immunohistochemistry in tumor diagnosis -- Immunohistochemical markers for the diagnosis of epithelial tumors -- Markers and immunoprofile of upper respiratory tract and pulmonary tumors -- Markers and immunoprofile of thymic epithelial tumors -- Markers and immunoprofile of heart and pericardium tumors -- Markers and immunoprofile of tumors of the oral cavity and salivary gland tumors -- Markers and immunoprofile of tumors gastrointestinal tract -- Markers and immunoprofile of exocrine pancreatic tumors -- Markers and immunoprofile of hepatobiliary tumors -- Markers and immunoprofile of hepatobiliary tumors -- Markers and immunoprofile of breast tumors -- Markers and immunoprofile of tumors of female reproductive organs -- Markers and immunoprofile of renal and urinary tract tumors -- Markers and immunoprofile of male genital tract tumors -- Markers and immunoprofile of endocrine and neuroendocrine tumors -- Markers and immunoprofile of mesothelioma tumors of the peritoneum -- Markers and immunoprofile of lymphoid tissue neoplasms -- Markers and immunoprofile of myeloid neoplasm -- Markers and immunoprofile of Mastocytosis -- Markers and immunoprofile of histiocytic and dendritic cell tumors -- Markers and immunoprofile of skin tumors -- Markers and immunoprofile of melanocytic tumors -- Markers and immunoprofile of fibroblastic, myofibroblastic and fibrohistiocytic tumors -- Markers and immunoprofile of muscle tumors -- Markers and immunoprofile of vascular and perivascular tumors -- Markers and immunoprofile of adipocytic tumors -- Markers and immunoprofile of peripheral nerve- and nerve sheet tumors -- Markers and immunoprofile of the central nervous system tumors -- Markers and immunoprofile of Ewing's sarcoma / primitive neuroectodermal tumors (PNET) -- Markers and immunoprofile of extraskeletal osseous and cartilaginous tumors -- Markers and immunoprofile of miscellaneous tumors and tumors of uncertain differentiation -- Markers to assist the diagnosis of dysplasia and malignant transformation -- Recommendations for the utility of immunohistochemistry in tumor diagnosis.
- Format
- e-Book
- Location
- Online
Neonatology : A Practical Approach to Neonatal Diseases
https://libcat.nshealth.ca/en/permalink/provcat42557
Giuseppe Buonocore, Rodolfo Bracci, Michael Weindling, editors.
(Second edition)
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addit…
- Available Online
- View e-Book
- Other Authors
- Buonocore, Giuseppe
- Bracci, Rodolfo
- Weindling, Michael
- Responsibility
- Giuseppe Buonocore, Rodolfo Bracci, Michael Weindling, editors
- Edition
- Second edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xiii, 2528 p.) : 568 illus., 358 illus. in color
- Series Title
- Springer reference
- ISBN
- 9783319294896
- 9783319294872 (print ed.)
- Subjects (MeSH)
- Infant, Newborn, Diseases
- Neonatology
- Specialty
- Neonatology
- Notes
- "eReference"--Publisher.
- Abstract
- This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.
- Contents
- Acute and Chronic Renal Failure in the Newborn Infant -- Anemia in the Neonatal Period -- Apnea of Prematurity and Sudden Infant Death Syndrome -- Bilirubin Metabolism, Unconjugated Hyperbilirubinemia, and Physiologic Neonatal Jaundice -- Biochemical Basis of Hypoxic-Ischemic Encephalopathy -- Blood Pressure Disorders in the Neonate: Hypotension and Hypertension -- Brain Development and Perinatal Vulnerability to Cerebral Damage -- Bronchopulmonary Dysplasia/Chronic Lung Disease of the Newborn -- Calcium and Phosphorus Homeostasis of Newborns: Pathophysiology -- Cardiac Emergencies in the Newborn -- Cardiovascular Physiology, Pathology, and Clinical Investigation in Neonatal Medicine -- Care of Extremely Low Birth Weight Infants and Timing of Discharge. Information and Psychosocial Intervention in Neonatology. -- Cerebral Hemorrhage in Newborns -- Cerebral Plasticity and Functional Reorganization in Children with Congenital Brain Lesions -- Clinical Aspects and Treatment of the Hypoxic-Ischemic Syndrome -- Coagulation Disorders in Newborns: Clinical Aspects of Platelet Disorders -- Congenital Immunodeficiencies in Newborns -- Congenital Malformations and Syndromes: Early Diagnosis and Prognosis in Neonatal Medicine -- Congenital Malformations of the Brain: Prenatal Diagnosis, Spectrum and Causes -- Continuous Positive Airways Pressure and other Non-Invasive Ventilation Techniques in Newborns -- Control of Breathing in Newborns -- Creactive Protein and Procalcitonin: Reference Intervals in Term and Preterm Newborns -- Development and General Characteristics of Preterm and Term Newborn -- Developmental Pharmacology and Therapeutics in Neonatal Medicine -- Diagnosis and Treatment of Renal and Urinary Tract Malformations in Newborns -- Diagnosis of Fetal Distress -- Disorders of Sexual Development in Newborns -- Early Detection of Neonatal Depression and Asphyxia -- Early Diagnosis of Congenital Heart Disease: When and How to Treat -- Early Markers of Poor Outcome in Neonatal Medicine -- Endocrine Diseases and Disorders of Thyroid Function in Newborns -- Enteral Feeding of the Very Low Birth Weight Infant -- Environment and Early Developmental Care for Newborns -- Epidemiology of Adverse Cerebral Outcome of Newborns -- Epidemiology: Mortality, Morbidity and Follow Up of High Risk Newborns -- Epigenetic Mechanisms -- Esophageal Atresia of Newborns -- Ethical Problems in Neonatal Medicine -- Extracorporeal Membrane Oxygenation for Neonates -- Feeding the Term Infant: Human Milk and Formulas -- Fetal and Neonatal Hydrops -- Fetal Infections: Congenital Syphilis and Tuberculosis -- Fetal Infections: Cytomegalovirus, Herpes Simplex, and Varicella -- Fetal infections: Rubella, HIV, HCV, HBV, and Human Parovirus B19 -- Follow-up Outcomes of High Risk Infants -- Fundamentals of Feto-Neonatal Immunology and Its Clinical Relevance -- Gastroenteritis and Intractable Diarrhea in Newborns -- Gastrointestinal Malformations of Newborns -- Guidelines and Protocols for Newborns -- Hematology and Immunology of Newborns: Overview -- Hirschsprung's Disease in Newborns -- Hormones and Gastrointestinal Function of Newborns -- Human Milk and Formulas for Neonatal Nutrition -- In Vitro Fertilization and Multiple Pregnancies -- Inborn Errors of Metabolism and Newborns -- Infants of Diabetic Mothers -- Infants of Smoking Mothers -- Inflammation and Perinatal Brain Injury -- Inflammatory Mediators in Neonatal Asphyxia and Infection -- Intrauterine Growth Restriction: Obstetric and Neonatal Aspects. Intervention Strategies. -- Kernicterus, Bilirubin-Induced Neurological Dysfunction, and New Treatments for Unconjugated Hyperbilirubinemia in Neonates -- Laboratory Medicine: Reference Intervals for Laboratory Tests and Procedures -- Laboratory Medicine: Reference Values and Evidence Based Medicine -- Late Preterm Infants at Risk for Short-Term and Long Term Morbidity and Mortality -- Lung Diseases: Problems of Steroid Treatment of Fetus and Newborn -- Lung Diseases: Surfactant Replacement Therapy in Newborns -- Lung Ultrasounds in Neonatal Diagnostic -- Malformations of Cortical Development in Newborns: Genetic Aspects -- Meconium Aspiration Syndrome -- Meconium Plug Syndrome -- Micronutrients and Vitamins of Newborns -- Molecular Structure of Surfactant: Biochemical Aspects in Newborns -- Necrotizing Enterocolitis of Newborns -- Neonatal Anesthesia -- Neonatal Bacterial and Fungal Infections -- Neonatal Care in the Delivery Room: Initial Management and Approach To Low Risk Newborns -- Neonatal Cholestasis-Conjugated Hyperbilirubinemia -- Neonatal Electroencephalography -- Neonatal Hereditary Neutropenia -- Neonatal Lung Development and Pulmonary Malformations -- Neonatal Malignancies -- Neonatal Orthopedic Surgery -- Neonatal Pain: Neurophysiology, Recognition, Prevention and Management with Non-Pharmacological Interventions -- Neonatal Pulmonary Physiology of Term and Preterm Newborns -- Neonatal Seizuresá -- Neonatal Septic Shock -- Neonatal Skin Disorders -- Neonatal Stroke: Clinical Presentation, Imaging, Treatment, and Prognosis -- Neonatal Stroke: Mechanisms -- Neonatal Transport Services -- Neonatal Viral Infections: Enteroviruses and Respiratory Syncytial Virus -- Neonatology and the Law -- Neuroimaging Studies of Newborns -- Neurological Examination of the Newborn Infantá -- Neuromuscular Disorders in Newborns -- Neuroprotective Strategies for Newborns -- Normal and Abnormal Neurodevelopmental and Behavioral Outcomes of Very Low-Birth Weight (VLBW) Infants -- Nutritional Recommendations for the Very Low Birth Weight Newborn -- Ocular Malformations in Newborns -- Organization of Perinatal Care. Training of Doctors and Nurses -- Orofacial Malformations -- Oxygen Saturation Monitoring in Neonatal Period -- Oxygen Toxicity in Newborns -- Parenteral Nutrition of Newborns -- Patent Ductus Arteriosus in Newborns -- Pathologic Unconjugated Hyperbilirubinemia, Isoimmunization, Abnormalities of Red Blood Cells, and Infections -- Pathology and Treatment of Liver Diseases in Newborns -- Pathophysiology of Coagulation and Deficiencies of Coagulation Factors in Newborns -- Pathophysiology of Fetal and Neonatal Kidneys -- Persistent Pulmonary Hypertension of the Newborn and Congenital Diaphragmatic Hernia: Nitric Oxide Therapy in Neonatology -- Physical Environment for Newborns: the Thermal Environment -- Physical Examination of the Newborn -- Physiology and Abnormalities of Leukocytes in Newborns -- Physiology of the Gastrointestinal Tract in Newborns -- Polycythemia and Hyperviscosity in Neonates -- Post-Discharge Nutrition in Preterm Infants -- Prenatal and Postnatal Inflammatory Mechanisms -- Primary Investigations in the Term and Preterm Newborn -- Problems of Discharge and Home Care of Newborns -- Pulmonary Air Leakage in Newborns -- Pulmonary Hemorrhage, Transient Tachypnea and Neonatal Pneumonia -- Quality of Neonatal Intensive Care and Outcome for High Risk Newborn Infants -- Rare Lung Diseases of Newborns -- Rare Surgical Emergencies of Newborns -- Recombinant G-CSF Treatment of Severe Chronic Neutropenia in Neonates and Infants -- Rehydration after Diarrhea in Newborns -- Respiratory Distress Syndrome: Predisposing Factors, Pathophysiology, and Diagnosis -- Resuscitation of the Newborn -- Retinopathy of Prematurity -- Risk Factors for Gestational Diseases -- Risk Management of Newborns -- Safety of Medications During Pregnancy and Breastfeeding: Infants of Drug-Addicted Mothers -- Surfactant Metabolism in Neonatal Lung Diseases -- Surgical Treatment in Newborns of Necrotizing Enterocolitis -- Surgical Treatment of Biliary Tract Malformations in Newborns -- The Fetus at Risk: Chorioamnionitis -- The Process of Decision-Making in Neonatology -- The Thrombotic Risk of the Newborn -- The Timing of Neonatal Brain Damage -- Toxoplasmosis in the Fetus and in the Newborn -- Treatment of Hyperbilirubinemia in Newborns -- Treatment of Respiratory Failure in Newborn: Mechanical Ventilation -- Vaccinations and Neonatal Immunity.
- Format
- e-Book
- Location
- Online
The Clinical Application of Homocysteine
https://libcat.nshealth.ca/en/permalink/provcat42569
Seema Bhargava.
--Singapore:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book helps clinicians to optimally and appropriately utilize homocysteine levels in the diagnosis, prediction and management of and research into vascular disease and many other conditions. It also familiarizes readers with the pathophysiology and clinical implications of hyperhomocysteinemia. Laboratory investigations are gaining importance in the diagnosis and prognosis of patients, and as such, scientists and laboratorians are constantly attempting to identify new markers that will help…
- Available Online
- View e-Book
- Author
- Bhargava, Seema
- Responsibility
- Seema Bhargava
- Place of Publication
- Singapore
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xix, 96 p.) : 19 illus. in color
- ISBN
- 9789811076329
- 9789811076312 (print ed.)
- 9789811076336 (print ed.)
- Subjects (MeSH)
- Homocysteine
- Homocysteinemia
- Specialty
- Biochemistry
- Cardiology
- Abstract
- This book helps clinicians to optimally and appropriately utilize homocysteine levels in the diagnosis, prediction and management of and research into vascular disease and many other conditions. It also familiarizes readers with the pathophysiology and clinical implications of hyperhomocysteinemia. Laboratory investigations are gaining importance in the diagnosis and prognosis of patients, and as such, scientists and laboratorians are constantly attempting to identify new markers that will help in earlier diagnosis and better prognostication of conditions with high morbidity and mortality, as well as high prevalence. According to the WHO, developing countries are home to 80% of patients with coronary artery disease (CAD) and stroke—conditions with a mortality second only to cancer. Intensive research in these areas has resulted in the identification of homocysteine (declared the 'marker of the millennium') and several new markers for the diagnosis and prediction of CAD and stroke. The book is a valuable resource for clinicians and consultants in practice, as well as for postgraduate and undergraduate students of medicine, biotechnology and biochemistry.
- Contents
- Part I: Homocysteine and Homocysteinemia -- 1. Introduction -- 2. Homocysteine: Discovery and Metabolism -- Part II: Clinical Implications of Homocysteinemia -- 3. Homocysteine in Occlusive Vascular Disease -- 4. Homocysteinemia and Hypertension -- 5. Homocysteinemia and Its Neurological Effects -- 6. Homocysteinemia in Nephrology Practice -- 7. Homocysteinemia and Oncology -- 8. Homocysteinemia and Otology -- 9. Homocysteinemia and Bones -- 10. Hydrogen Sulphide: The Body’s Inherent Defence Against Homocysteinemia -- 11. Homocysteine and Epigenetics -- 12. J Food Fortification.
- Format
- e-Book
- Location
- Online
Genitourinary Cancers
https://libcat.nshealth.ca/en/permalink/provcat42703
Siamak Daneshmand, Kevin G. Chan, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techni…
- Available Online
- View e-Book
- Other Authors
- Daneshmand, Siamak
- Chan, Kevin G.
- Responsibility
- Siamak Daneshmand, Kevin G. Chan, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vi, 308 p.) : 39 illus., 38 illus. in color
- Series Vol.
- 175
- Series Title
- Cancer treatment and research
- ISBN
- 9783319933399
- 9783319933382 (print ed.)
- 9783319933405 (print ed.)
- ISSN
- 0927-3042
- Subjects (MeSH)
- Urogenital Neoplasms - diagnosis
- Urogenital Neoplasms - genetics
- Urogenital Neoplasms - therapy
- Specialty
- Medical Oncology
- Urology
- Abstract
- This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.
- Contents
- New imaging techniques in prostate cancer -- Targeted ablative therapies for prostate cancer -- Prostate cancer markers -- Prognostic value of CTC's in urologic cancers -- Management of small renal masses -- Advances in the treatment of metastatic renal cell carcinoma -- Imaging in urologic cancers -- Molecular prognostication in bladder cancer -- Early cystectomy for high risk non-muscle invasive disease -- Care-coordination pathway after radical cystectomy -- Current role of checkpoint inhibitors in urologic cancers -- The Cancer Genome Atlas Project -- Prognostic models in germ cell tumors -- Modern management of testicular cancer.
- Format
- e-Book
- Location
- Online
Advances in Treatments for Aortic Valve and Root Diseases
https://libcat.nshealth.ca/en/permalink/provcat42765
Khalil Fattouch, Patrizio Lancellotti, Mani A. Vannan, Giuseppe Speziale, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book describes the different aspects of aortic valve and root diseases including comprehensive discussion of the state-of-the-art diagnostic imaging options, disease risk stratification, selection of candidates for valve repair or percutaneous intervention, and most recent therapeutic options. The growing prevalence of valvular heart disease represents a major challenge in terms of short- and long-term management and surveillance. Aortic valve diseases, including aortic stenosis and regurg…
- Available Online
- View e-Book
- Responsibility
- Khalil Fattouch, Patrizio Lancellotti, Mani A. Vannan, Giuseppe Speziale, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (vii, 418 p.) : 177 illus., 151 illus. in color
- ISBN
- 9783319664835
- 9783030097738 (print ed.)
- 9783319664828 (print ed.)
- 9783319664842 (print ed.)
- Subjects (MeSH)
- Aortic Diseases - surgery
- Specialty
- Cardiovascular Surgical Procedures
- Abstract
- This book describes the different aspects of aortic valve and root diseases including comprehensive discussion of the state-of-the-art diagnostic imaging options, disease risk stratification, selection of candidates for valve repair or percutaneous intervention, and most recent therapeutic options. The growing prevalence of valvular heart disease represents a major challenge in terms of short- and long-term management and surveillance. Aortic valve diseases, including aortic stenosis and regurgitation, are among the most frequent of these, while the number of cases of aortic root disease is also on the rise. Aortic valve disease treatment options include valve surgery, valve repair, minimally invasive valve surgery, and percutaneous approaches and all are covered in this volume. Advances in Treatments for Aortic Valve and Root Diseases is a highly illustrated, case oriented reference aimed at cardiology fellows in training, while also helpful to surgeons, cardiologists, imagers, interventionalists, as well as other clinicians and students involved in the diagnosis and treatment of aortic valve and root diseases.
- Contents
- Part I. Anatomy -- 1. The Clinical Anatomy of the Aortic Root -- 2. Aortic Root Anatomy and Physiology -- 3. Functional Anatomy and Dynamics of the Aortic Root -- Part II. Imaging -- 4. Multimodality Imaging Assessment of Aortic Stenosis -- 5. Multimodality Imaging Assessment of Aortic Regurgitation -- 6. Stress Echocardiography in Aortic Valve Disease -- 7. Multimodality Imaging Assessment of Prosthetic Aortic Valve -- 8. Aortic-Mitral Coupling -- 9. 4D Flow Imaging in Aortic Disease -- Part III Aortic Valve Annuloplasty Techniques -- 10. External Aortic Ring Annuloplasty to Standardize Aortic Valve Repair -- 11. Aortic Annulus Stabilization Using Internal Rings -- Part IV. Aortic Root Surgery Techniques -- 12. Root Replacement with Biological Valved Conduits -- 13. Aortic Valve Sparing: Reimplantation Technique -- 14. Right Anterior Mini-Thoracotomy -- 15. Modified David Operation: A New Simple Method Using a Single Inflow Suture Line -- 16. Redo Surgery for Aortic Valve and Root: Demographics and Operative Options -- Part V. Minimal Invasive Aortic Valve Surgery -- 17. Mini-Sternotomy -- 18. Right Anterior Mini-Thoracotomy for Aortic Valve Replacement -- 19. Totally Endoscopic Aortic Valve Replacement (TEAVR) -- 20. Sutureless Aortic Valve Implantation -- Part VI. Transcatheter Aortic Valve Implantation -- 21 Trans-Catheter Aortic Valve Replacement: Procedure Planning and Guidance -- 22. Transfemoral TAVI: Devices and Techniques -- 23. Transcatheter Aortic Valve Implantation (TAVI) Using the Transapical Approach -- 24. Hot Topics in TAVI: Paravalvular Leak, Thrombosis, PM Implantation, Stroke, Durability -- 25. The Impact of Surgical and Trans-Catheter Aortic Valve Replacement on Endothelial Function: New Markers Ahead -- 26. Risk Assessment -- Part VII. Heart Valve Clinic -- 27. The Heart Valve Centre.
- Format
- e-Book
- Location
- Online
Lung Transplantation : Evolving Knowledge and New Horizons
https://libcat.nshealth.ca/en/permalink/provcat42806
Ganesh Raghu, Roberto G. Carbone, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book details all aspects of lung transplantation and equips the general pulmonologist/physician with the necessary tools and knowledge to assist patients with the preparation for and care post lung transplantation. Written by global experts, chapters present general principles and history; indications and eligibility for lung transplantation, including screening for COPD, cystic fibrosis, scleroderma, Idiopathic pulmonary fibrosis (IPF) and idiopathic pulmonary arterial hypertension; appro…
- Available Online
- View e-Book
- Other Authors
- Raghu, Ganesh
- Carbone, Roberto G.
- Responsibility
- Ganesh Raghu, Roberto G. Carbone, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xviii, 371 p.) : 180 illus., 101 illus. in color
- ISBN
- 9783319911847
- 9783319911823 (print ed.)
- 9783319911830 (print ed.)
- Subjects (MeSH)
- Lung Transplantation
- Specialty
- Pulmonary Medicine
- Transplantation
- Abstract
- This book details all aspects of lung transplantation and equips the general pulmonologist/physician with the necessary tools and knowledge to assist patients with the preparation for and care post lung transplantation. Written by global experts, chapters present general principles and history; indications and eligibility for lung transplantation, including screening for COPD, cystic fibrosis, scleroderma, Idiopathic pulmonary fibrosis (IPF) and idiopathic pulmonary arterial hypertension; approach to and complications of lung transplantation, such as prognostic markers, radiological approach, and immunology and rejection; and medical and surgical guidelines for lung transplantation. The goal of lung transplantation is to increase survival and to provide a greater quality of life for patients with untreatable end-stage lung disease and this book serves to best prepare clinicians in achieving that goal. Lung Transplantation: Evolving knowledge and New horizons offers valuable insights into this modality and is an authoritative resource for multidisciplinary services that include experts in pulmonary diseases, critical care, cardiology, thoracic surgery, infection diseases, internal medicine, radiology, immunology, nephrology, rehabilitation, psychology /psychiatry, nurses, social workers and nutritionists.
- Contents
- Part I. General Principles and Considerations for Lung Transplantation -- The History of Lung Transplantation -- Single and Bilateral Lung Transplantation: Indications, Contraindications, Evaluation, and Requirements for Patients to be Considered Eligible -- Pretransplant Considerations in Patients with Obstructive Lung Disease: COPD, Lymphangioleiomyomatosis, Cystic Fibrosis, and Non-CF Bronchiectasis -- Pretransplant Considerations in Patients with Pulmonary Fibrosis -- Pulmonary Vascular Disease: Specific Evaluation and Timing for Listing Eligible Patients to Receive Lung Transplantation and Management of the Pre-Lung Transplant Patient -- Psychosocial Evaluation of the Patient Considered for Lung Transplant -- Prognostic Markers and the LAS for Lung Transplantation: Impact of New Revisions for Successful Outcome -- Part II. The Donor Lung and the Lung Transplant Recipient -- Management of the Donor and Recipient: Surgical Management -- Immunology in Lung Transplantation -- Physiologic and Epigenetic Changes with Pulmonary Vascular Injury after Lung Transplantation -- Part III. The Lung Transplant Recipient: Medical Management -- Medical Management of the Lung Transplant Recipient: Extra-Pulmonary Issues -- Management of Cellular and Humoral Rejection: Prevention, Diagnosis, and Treatment -- Pathology of Lung Rejection: Cellular and Humoral Mediated -- Prevention and Treatment Regimens for Non-Viral Infections in the Lung Transplant Recipient -- Respiratory Viruses and Other Relevant Viral Infections in the Lung Transplant Recipient -- Lung Allograft (LAD) and Bronchiolitis Obliterans Syndrome -- Gastroesophageal Reflux and Esophageal Dysmotility in Patients Undergoing Evaluation for Lung Transplantation: Assessment, Evaluation, and Management -- Management of Airway Stenosis in the Lung Allograft: Bronchoscopy Procedures -- Imaging of Lung Transplantation -- Part IV. Lung Transplantation: Future Directions -- New Horizons in Lung Transplantation -- Gaps and Future Directions in Lung Transplantation.
- Format
- e-Book
- Location
- Online
The Infected Total Knee Arthroplasty : Prevention, Diagnosis, and Treatment
https://libcat.nshealth.ca/en/permalink/provcat42848
E. Carlos Rodríguez-Merchán, Sam Oussedik, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book is structured in a way that guides the reader from prevention through to diagnosis and then treatment of infection following total knee arthroplasty, in each case providing state of the art information on available techniques and procedures. The section on the crucial preventive measures include guidance on preoperative optimization and skin preparation, antibiotic prophylaxis, and preoperative microbiological screening. All relevant aspects of diagnosis of infection are considered in…
- Available Online
- View e-Book
- Other Authors
- Rodríguez-Merchán, E. Carlos
- Oussedik, Sam
- Responsibility
- E. Carlos Rodríguez-Merchán, Sam Oussedik, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (viii, 191 p.) : 45 illus., 38 illus. in color
- ISBN
- 9783319667300
- 9783319667294 (print ed.)
- 9783319667317 (print ed.)
- 9783319883076 (print ed.)
- Subjects (MeSH)
- Arthroplasty, Replacement, Knee - adverse effects
- Postoperative Complications
- Prosthesis-Related Infections - diagnosis
- Prosthesis-Related Infections - therapy
- Reoperation
- Specialty
- Orthopedic Procedures
- Abstract
- This book is structured in a way that guides the reader from prevention through to diagnosis and then treatment of infection following total knee arthroplasty, in each case providing state of the art information on available techniques and procedures. The section on the crucial preventive measures include guidance on preoperative optimization and skin preparation, antibiotic prophylaxis, and preoperative microbiological screening. All relevant aspects of diagnosis of infection are considered in detail, and the treatment-related section includes chapters on antibiotic suppression, arthroscopic lavage, open debridement with polyethylene exchange, one- and two-stage revision arthroplasty, and knee arthrodesis as a salvage procedure. Readers will also find clear instruction on how to proceed when all attempts to eradicate infection fail. In reflecting the latest knowledge and practice in this rapidly advancing field, the book will be an asset to all who are involved in the care of these patients.
- Contents
- Epidemiology of the infected total knee arthroplasty: incidence, causes and the burden of disease -- Microbiological concepts of the infected total knee arthroplasty -- Preoperative optimization to prevent an infected total knee arthroplasty: Host factors -- Depilation and skin preparation to prevent an infected total knee arthroplasty -- Antibiotic prophylaxis to prevent infection in total knee arthroplasty -- Preoperative screening and eradication of infection -- Clinical diagnosis of the infected total knee arthroplasty -- Diagnosis by imaging of the infected total knee arthroplasty -- Serological markers of infection in the infected total knee arthroplasty -- The role of knee aspiration in the infected total knee arthroplasty -- Polymerase chain reaction (PCR) in the infected total knee arthroplasty -- Histological diagnosis in the infected total knee arthroplasty -- Intra-operative Cultures for the Suspected Total Knee Arthroplasty Infection -- Sonication of removed implants in the infected total knee arthroplasty -- Antibiotic suppression in the infected total knee arthroplasty -- Arthroscopic debridement of infected total knee arthroplasty -- Open debridement and polyethylene exchange (ODPE) in the infected total knee arthroplasty -- One-stage revision arthroplasty in the infected total knee arthroplasty -- Two-stage revision of infected total knee arthroplasty -- Knee arthrodesis in the infected total knee arthroplasty -- Above knee amputation in the treatment of failed septic total knee arthroplasty.
- Format
- e-Book
- Location
- Online
Rectal Cancer : Modern Approaches to Treatment
https://libcat.nshealth.ca/en/permalink/provcat42957
edited by George J. Chang.
--Cham, Switzerland:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
Rectal Cancer: Modern Approaches to Treatment provides a useful overview of the multidisciplinary treatment of rectal cancer with a deeper dive into clinical challenges faced by treating physicians. Written by the leading experts in the field, it provides a practical management guide with an emphasis on the state-of-the-art that will be of value to both novices and experts engaged in rectal cancer treatment.
- Available Online
- View e-Book
- Other Authors
- Chang, George J.
- Responsibility
- edited by George J. Chang
- Place of Publication
- Cham, Switzerland
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (ix, 375 p.) : 210 illus., 172 illus. in color
- ISBN
- 9783319163840
- 9783319163833 (print ed.)
- 9783319163857 (print ed.)
- 9783319792262 (print ed.)
- Subjects (MeSH)
- Combined Modality Therapy - methods
- Digestive System Surgical Procedures - methods
- Rectal Neoplasms - surgery
- Specialty
- Colorectal Surgery
- Surgical Oncology
- Abstract
- Rectal Cancer: Modern Approaches to Treatment provides a useful overview of the multidisciplinary treatment of rectal cancer with a deeper dive into clinical challenges faced by treating physicians. Written by the leading experts in the field, it provides a practical management guide with an emphasis on the state-of-the-art that will be of value to both novices and experts engaged in rectal cancer treatment.
- Contents
- Introduction: the Multidisciplinary Approach -- Clinical Anatomy of the Rectum -- Endorectal Ultrasound -- Magnetic Resonance Imaging of the Rectum -- Radiographic Evaluation for Systemic Disease -- Local Excision -- Transanal Endoscopic Microsurgery (TEM) and Transanal Minimally Invasive Surgery (TaMIS) -- Preoperative Radiotherapy and Chemoradiotherapy -- Total Mesorectal Excision -- Coloanal Reconstruction and Intersphincteric Resection -- Abdominoperineal Excision -- Lateral Pelvic Lymph Node Dissection -- Laparoscopic Rectal Surgery -- Robotic Rectal Surgery -- Composite Resection for Primary Rectal Cancer -- Evaluation and Treatment of Locally Recurrent Rectal Cancer -- Reconstruction of the Pelvis and Perineum -- Primary Tumor Management in Stage IV Rectal Cancer -- Systemic Chemotherapy -- Intraoperative Radiation Therapy -- Palliative Treatment -- Quality of Life After Multidisciplinary Management of Rectal Cancer -- Maximizing Neoadjuvant Treatment Response -- Standards for Pathologic Evaluation -- Molecular Markers and Mutational Analysis.
- Format
- e-Book
- Location
- Online
Right Heart Pathology : From Mechanism to Management
https://libcat.nshealth.ca/en/permalink/provcat43021
Silviu Ionel Dumitrescu, Ion C. Tintoiu, Malcolm John Underwood, editors.
--Cham:
Springer
, c2018.
- Available Online
- View e-Book
- Location
- Online
This book reviews the management of right heart diseases, incorporating etiology, physiopathology, prevention, diagnosis and treatment. The frequency of this pathology has increased in recent years, while techniques for its treatment have evolved. This book therefore represents a complete, detailed and updated presentation of this pathology, reviewing the expanded treatment options while considering the management of patients in detail. Right Heart Pathology: From Mechanism to Management provid…
- Available Online
- View e-Book
- Other Authors
- Dumitrescu, Silviu Ionel
- Tintoiu, Ion C.
- Underwood, Malcolm John
- Responsibility
- Silviu Ionel Dumitrescu, Ion C. Tintoiu, Malcolm John Underwood, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2018
- Physical Description
- 1 online resource (xiv, 935 p.) : 384 illus., 261 illus. in color
- ISBN
- 9783319737645
- 9783319737638 (print ed.)
- 9783319737652 (print ed.)
- Subjects (MeSH)
- Heart Failure - diagnosis
- Heart Failure - therapy
- Heart Ventricles - physiopathology
- Ventricular Dysfunction, Right - physiopathology
- Ventricular Function, Right - physiology
- Specialty
- Cardiology
- Abstract
- This book reviews the management of right heart diseases, incorporating etiology, physiopathology, prevention, diagnosis and treatment. The frequency of this pathology has increased in recent years, while techniques for its treatment have evolved. This book therefore represents a complete, detailed and updated presentation of this pathology, reviewing the expanded treatment options while considering the management of patients in detail. Right Heart Pathology: From Mechanism to Management provides a comprehensive insight into right heart pathology, current diagnostic methods, treatments and postsurgical management. Written by experienced cardiologists and cardiovascular surgeons who have addressed significant issues in this topic area, it represents the essential reference in this specialty.
- Contents
- Morphogenesis of the Right Heart -- Molecular, and Cellular Biology -- Right Ventricular Normal Function -- Effect of Endurance sport -- Systolic and Diastolic Dysfunction -- Hypertrophy and dilatation, markers of dysfunction -- Physiopathology -- Acute Right Heart Failure -- Chronic Right Heart Failure -- Systemic Consequences of Right Ventricular Failure -- Congenital Heart Disease and Right Heart -- Primary and Secondary Pulmonary Hypertension -- Tricuspid Valve Pathology -- Right Atrium and Ventricle in Cardiac Pacing -- Right Heart in Dilated Cardiomyopathy -- Arrhythmogenic Right Ventricular Dysplasia -- Left Heart Pathology and Right Ventricle Function -- Myocardial infarction of the right ventricle -- Pulmonary Disease and Right Ventricular Function -- Arrhythmias in Right Heart Disease -- Pulmonary Thromboembolism -- Right ventricular disfunction in hypertrophic cardiomyopathy -- Myxoma -- Primary Tumors -- Clinical Signs and Electrocardiography -- Chest x ray -- Transthoracic Echocardiography (3D and 4D) -- Transoesophagial Echocardiography -- Echocardiographic assessment of the tricuspid valve/RV function -- Stress Test -- CT imaging -- Magnetic Resonance Imaging -- Drugs Therapy -- Inhaled vasodilators in right heart failure -- Importance of the extra-cardiac manifestations of right heart failure using bedside ultrasound -- Interventional Procedures (Atrial Septostomy, Amplazer Devices, Balloon valvuloplasty) -- Cardiac Surgery in noncongenital diseases -- Cardiac Surgery in congenital heart diseases -- Surgical Management of Functional Tricuspid Regurgitation -- Re-Operative Tricuspid Valve Surgery: Challenges and Strategy -- Heart and Lung Transplant -- Type of support of RV -- Right Ventricular Disfunction in Cardiac Surgery -- Guidelines in Right Ventricular Failure -- Future Direction.
- Format
- e-Book
- Location
- Online
