Skip header and navigation
Did you mean markets?

Narrow By

176 records – page 1 of 9.

PET and SPECT of Neurobiological Systems

https://libcat.nshealth.ca/en/permalink/provcat46365
Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, editors ; Adriaan A. Lammertsma, guest editor. (Second edition) --Cham: Springer , c2021.
Available Online
View e-Book
Access
NEW Springer 2021
Location
Online
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, ß-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development ar…
Available Online
View e-Book
Other Authors
Dierckx, Rudi A.J.O.
Otte, Andreas
de Vries, Erik F.J.
van Waarde, Aren
Lammertsma, Adriaan A.
Responsibility
Rudi A.J.O. Dierckx, Andreas Otte, Erik F.J. de Vries, Aren van Waarde, editors ; Adriaan A. Lammertsma, guest editor
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (xii, 1132 p.) : 374 illus., 165 illus. in color
ISBN
9783030531768
9783030531751 (Print ed.)
9783030531775 (Print ed.)
9783030531782 (Print ed.)
Subjects (MeSH)
Neurobiology - methods
Positron-Emission Tomography
Tomography, Emission-Computed, Single-Photon
Specialty
Diagnostic Imaging
Neurology
Physiology
Abstract
This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, ß-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.
Contents
Part I. Basics -- 1. Animal Models for Brain Research -- 2. The Use of Small Animal Molecular Imaging (µPET) Exemplified in a Neurobiological Pathology -- 3. Total-Body PET -- 4. Cerebral Glucose Metabolism -- 5. Cerebral Blood Flow Measurement with Oxygen-15 Water Positron Emission Tomography -- 6. The Impact of Genetic Polymorphisms on Neuroreceptor Binding: Results from PET and SPECT Neuroreceptor Imaging Studies -- Part II. Systems -- 7. PET Imaging of Acetylcholinesterase -- 8. Imaging of Adenosine Receptors -- 9. Imaging of Central Benzodiazepine Receptors in Chronic Cerebral Ischemia -- 10. PET Imaging of Cyclooxygenases in Neuroinflammation -- 11. PET and SPECT Imaging of the Central Dopamine System in Humans -- 12. PET Imaging of the Endocannabinoid System -- 13. Current Radioligands for the PET Imaging of Metabotropic Glutamate Receptors -- 14. PET and SPECT Imaging of Steroid Hormone Receptors in the Brain -- 15. PET Imaging of Monoamine Oxidase B -- 16. Attempts to Image MRP1 Function in the Blood-Brain Barrier Using the Metabolite Extrusion Method - 17. Neuroinflammation: From Target Selection to Preclinical and Clinical Studies -- 18. Preclinical and Clinical Aspects of Nicotinic Acetylcholine Receptor Imaging -- 19. Development of PET and SPECT Radioligands for In Vivo Imaging of NMDA Receptors -- 20. Progress in PET Imaging of the Norepinephrine Transporter System -- 21. Positron Emission Tomography (PET) Imaging of Opioid Receptors -- 22. PET Imaging of ABC Transporters at the Blood-Brain Barrier -- 23. PET Imaging of Phosphodiesterases in Brain -- 24. PET Imaging of Purinergic Receptors -- 25. Imaging of the Serotonin System: Radiotracers and Applications in Memory Disorders -- 26. Monoamine Oxidase A and Serotonin Transporter Imaging with Positron Emission Tomography -- 27. PET Imaging of Sigma1 Receptors -- 28. Sigma-2 Receptors: An Emerging Target for CNS PET Imaging Studies -- 29. PET Imaging of Synaptic Vesicle Protein 2A -- 30. PET Imaging of Translocator Protein Expression in Neurological Disorders -- 31. Toward Imaging Tropomyosin Receptor Kinase (Trk) with Positron Emission Tomography -- 32. Radioligand Development for PET Imaging of the Vesicular Acetylcholine Transporter (VAChT) in the Brain -- 33. PET Imaging of Vesicular Monoamine Transporters.
Access
NEW Springer 2021
Format
e-Book
Location
Online
Less detail

COVID-19 in New York City : An Ecology of Race and Class Oppression

https://libcat.nshealth.ca/en/permalink/provcat46414
Deborah Wallace, Rodrick Wallace. --Cham: Springer , c2021.
Available Online
View e-Book
Access
NEW Springer 2021
Location
Online
This book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates revealed the "weathering" of policy-targeted communiti…
Available Online
View e-Book
Author
Wallace, Deborah
Other Authors
Wallace, Rodrick
Responsibility
Deborah Wallace, Rodrick Wallace
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (xi, 77 p.) : 29 illus., 3 illus. in color
Series Title
SpringerBriefs in public health
ISBN
9783030596248
9783030596231 (Print ed.)
9783030596255 (Print ed.)
ISSN
2192-3698
Subjects (MeSH)
COVID-19 - epidemiology
Healthcare Disparities
Health Policy
Health Status Disparities - ethnology
Minority Health
Sociology, Medical
Other Subjects
New York City
Specialty
Epidemiology
Infectious Disease Medicine
Minority Health
Public Health
Sociology, Medical
Abstract
This book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates revealed the "weathering" of policy-targeted communities: accelerated aging due to chronic stress. COVID attacks the elderly more severely than those under the age of 60. Communities with high proportions of prematurely aged residents proved fertile ground for COVID illness and mortality. The very public policies that created swaths of white wealth across much of Manhattan and parts of Brooklyn destroyed the human diversity needed to ride out crises. An exemplary study in health disparities, COVID-19 in New York City: An Ecology of Race and Class Oppression is essential reading for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also should appeal to students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.
Contents
1. Premature Death Rate Geography in New York City: Implications for COVID-19 -- 2. NYC COVID Markers at the ZIP Code Level -- 3. Prospero’s New Castles: COVID Infection and Premature Mortality in the NY Metro Region -- 4. Pandemic Firefighting vs. Pandemic Fire Prevention -- 5. Conclusion: Scales of Time in Disasters.
Access
NEW Springer 2021
Format
e-Book
Location
Online
Less detail

Therapeutic Lipidology

https://libcat.nshealth.ca/en/permalink/provcat46515
Michael H. Davidson, Peter P. Toth, Kevin C. Maki, editors. (Second edition) --Cham: Humana Press , c2021.
Available Online
View e-Book
Access
NEW Springer 2021
Location
Online
The second edition of this important book provides an up-to-date and comprehensive overview of clinical lipidology. Brand new chapters focus on recent advances in the field including novel biomarkers and the microbiome, genomics of cardiovascular risks, PCSK9 inhibitors, imaging technologies, and epidemiology of atherosclerotic cardiovascular disease. The book describes new guidelines, novel therapeutic agents, and changes in the understanding of specific lipoproteins and subclasses with regard…
Available Online
View e-Book
Other Authors
Davidson, Michael H.
Toth, Peter P.
Maki, Kevin C.
Responsibility
Michael H. Davidson, Peter P. Toth, Kevin C. Maki, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2021
Physical Description
1 online resource (xv, 689 p.) : 140 illus., 114 illus. in color
Series Title
Contemporary cardiology
ISBN
9783030565145
9783030565138 (Print ed.)
9783030565152 (Print ed.)
9783030565169 (Print ed.)
ISSN
2196-8969
Subjects (MeSH)
Dyslipidemias - therapy
Lipid Metabolism
Specialty
Physiology
Abstract
The second edition of this important book provides an up-to-date and comprehensive overview of clinical lipidology. Brand new chapters focus on recent advances in the field including novel biomarkers and the microbiome, genomics of cardiovascular risks, PCSK9 inhibitors, imaging technologies, and epidemiology of atherosclerotic cardiovascular disease. The book describes new guidelines, novel therapeutic agents, and changes in the understanding of specific lipoproteins and subclasses with regard to their relationships to cardiovascular disease risk. The second edition contains more than thirty chapters covering such topics as the history of lipidology, lipoprotein metabolism and vascular biology, disorders of lipid metabolism, lifestyle/dietary and pharmacologic management for dyslipidemia, the management of dyslipidemia in certain subgroups (e.g., women, children, older patients) and lipid testing, as well as an examination of other biomarkers and testing procedures related to atherosclerosis and cardiovascular disease. The second edition of Therapeutic Lipidology is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
Contents
1. History of Lipidology -- 2. Atherogenesis and Vascular Biology -- 3. Genetic Disorders of Lipoprotein Metabolism -- 4. Cardiovascular Genomics -- 5. Epidemiology of Atherosclerotic Cardiovascular Disease -- 6. Comparison of 2018 AHA-ACC Multi-Society Cholesterol Guidelines with 2013 ACC-AHA Cholesterol Guidelines -- 7. The Low-Density Lipoprotein Cholesterol Hypothesis: An Update -- 8. Triglyceride-rich Lipoprotein Cholesterol (Remnant Cholesterol) as a Therapeutic Target for Cardiovascular Disease Risk -- 9. Medical Nutrition Therapy for Lipid and Lipoprotein Disorders -- 10. Nutraceuticals and Lipid Management -- 11. Pharmacology of Statins -- 12. Management of Statin Intolerance -- 13. Intestinally Active Therapies for Hypercholesterolemia: Ezetimibe, Bile Acid Resins and Plant Sterols -- 14. Proprotein Convertase Subtilisin/Kexin Type 9: Functional Role in Lipid Metabolism and its Therapeutic Inhibition -- 15. Management of Hypertriglyceridemia (Including Fibrates and n-3 Fatty Acids) -- 16. Pathophysiology and Management of Dyslipidemias Associated with Insulin-resistant States -- 17. Therapeutic Management of Obesity -- 18. High Density Lipoproteins -- 19. Lipoprotein (a): Principles from Bench to Bedside -- 20. Management of Homozygous Familial Hypercholesterolemia -- 21. Lysosomal Acid Lipase Deficiency -- 22. Lipodystrophies -- 23. HIV and Dyslipidemia -- 24. Cardiovascular Disease in Women: Focus on Lipid Management -- 25. Management of Dyslipidemia in the Elderly -- 26. Management of Dyslipidemia in Children -- 27. Lipoprotein Subfractions in Clinical Practice -- 28. Ion Mobility Lipoprotein Analysis -- 29. How ApoB Measurements Could Improve Prevention of Cardiovascular Disease -- 30. C-reactive Protein and Other Inflammatory Markers in Cardiovascular Disease; Inflammatory Disorders and Atherosclerosis -- 31. Coronary Artery Calcium and CT Angiography -- 32. The Clinical Use of Ultrasound for Atherosclerosis Imaging -- 33. Emerging Therapies for Regulating Dyslipidemias and Atherosclerosis -- 34. The Allied Health Professional’s Role in the Management of Dyslipidemia and Accreditation Council for Clinical Lipidology Certification Program -- 35. The American Board of Clinical Lipidology Physician Certification Program.
Access
NEW Springer 2021
Format
e-Book
Location
Online
Less detail

Diagnostic histopathology of tumors

https://libcat.nshealth.ca/en/permalink/provcat32253
[edited by] Christopher D.M. Fletcher. (5th ed.) --Philadelphia, PA: Elsevier , c2021.
Available Online
View e-Book
Access
Registration required for PDF access.
Location
Online
Known for its clear writing style, easy-to-navigate format, and authoritative coverage of tumor pathology, Dr. Christopher Fletcher’s Diagnostic Histopathology of Tumors, 5th Edition, remains your go-to source for accurate, efficient evaluation and interpretation of histopathology specimens. This highly regarded reference provides superbly illustrated information on pathogenesis, diagnostic criteria, molecular/cytogenetic findings, and prognosis on the neoplastic diseases most likely to be enc…
Available Online
View e-Book
Other Authors
Fletcher, Christopher D. M.
Responsibility
[edited by] Christopher D.M. Fletcher
Edition
5th ed.
Alternate Title
Diagnostic histopathology of tumours
Place of Publication
Philadelphia, PA
Publisher
Elsevier
Date of Publication
c2021
Physical Description
1 online resource, 2440 p.
ISBN
9780323428606
Subjects (MeSH)
Neoplasms - pathology
Subjects (LCSH)
Tumors - Histopathology
Tumors - Diagnosis
Histology, Pathological
Neoplasms - pathology
Specialty
Diagnosis
Histology
Medical Oncology
Pathology
Abstract
Known for its clear writing style, easy-to-navigate format, and authoritative coverage of tumor pathology, Dr. Christopher Fletcher’s Diagnostic Histopathology of Tumors, 5th Edition, remains your go-to source for accurate, efficient evaluation and interpretation of histopathology specimens. This highly regarded reference provides superbly illustrated information on pathogenesis, diagnostic criteria, molecular/cytogenetic findings, and prognosis on the neoplastic diseases most likely to be encountered by general surgical pathologists, and helps you stay current with the latest diagnostic tumor markers to assist in daily sign-out.
Access
Registration required for PDF access.
Format
e-Book
Location
Online
Less detail

Cutaneous Melanoma

https://libcat.nshealth.ca/en/permalink/provcat44832
Charles M. Balch, Michael B. Atkins, Claus Garbe, Jeffrey E. Gershenwald, Allan C. Halpern, John M. Kirkwood, Grant A. McArthur, John F. Thompson, Arthur J. Sober, editors. (Sixth edition) --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors…
Available Online
View e-Book
Other Authors
Balch, Charles M.
Atkins, Michael B.
Garbe, Claus
Gershenwald, Jeffrey E.
Halpern, Allan C.
Kirkwood, John M.
McArthur, Grant A.
Thompson, John F.
Sober, Arthur J.
Responsibility
Charles M. Balch, Michael B. Atkins, Claus Garbe, Jeffrey E. Gershenwald, Allan C. Halpern, John M. Kirkwood, Grant A. McArthur, John F. Thompson, Arthur J. Sober, editors
Edition
Sixth edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxix, 1510 p.) : 371 illus., 301 illus. in color
ISBN
9783030050702
9783030050689 (Print ed.)
Subjects (MeSH)
Melanoma
Skin Neoplasms
Specialty
Dermatology
Medical Oncology
Abstract
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
Contents
Volume 1. Part I. Biology and Immunology of Melanoma -- Biology of Melanocytes and Primary Melanoma -- Immunology of Melanoma -- Biomarkers for Melanoma -- Part II. Diagnosis and Staging -- Clinical Presentations of Melanoma -- Dermoscopy/Confocal Microscopy -- Biopsy of Suspected Melanoma -- Lymphoscintigaphy in Patients With Melanoma -- Biopsy of the Sentinel Lymph Node -- Melanoma Prognosis and Staging -- Models for Predicting Melanoma Outcome -- Part III. Pathology - Classification and Histopathology of Melanoma -- Molecular Pathology and Genomics of Melanoma -- Part IV. Epidemiology and Prevention of Melanoma -- Clinical Epidemiology of Melanoma -- Molecular Epidemiology of Melanoma -- Clinical Genetics and Risk Assessment of Melanoma -- Acquired Precursor Lesions and Phenotypic Markers of Increased Risk for Cutaneous Melanoma -- Melanoma Prevention and Screening -- Part V. Management of Primary Melanoma and Locoregional Metastases -- Treatment of Primary Melanoma -- Reconstructive Options Following Surgery of Primary Melanoma -- Axillary and Epitrochlear Lymph Node Dissection for Melanoma -- Inguinofemoral, Iliac/Obturator, and Popliteal Lymphadenectomy for Melanoma -- Neck Dissection and Parotidectomy for Melanoma -- Local and Recurrent Regional Metastases of Melanoma -- Radiotherapy for Primary and Regional Melanoma -- Adjuvant Systemic Therapy for High-Risk Melanoma Patients -- Neoadjuvant Systemic Therapy for High-Risk Melanoma Patients -- Hyperthermic Regional Perfusion for Melanoma of the Limbs -- Isolated Limb Infusion for Melanoma -- Surveillance and Follow-up of Melanoma Patients -- Local melanoma recurrence, satellitosis and in transit metastasis: incidence, outcomes and selection of treatment options -- Volume 2. Part VI. Uncommon Presentations of Melanoma -- Acral Lentiginous Melanoma -- Lentigo Maligna Melanoma -- Mucosal Melanoma -- Melanoma in Children and Teenagers -- Pregnancy and the Use of Hormones in Melanoma Patients -- Diagnosis of Stage IV Melanoma -- Part VII. Management of Distant Metastases -- Evolving Role of Chemotherapy-Based Treatment of Metastatic Melanoma -- Targeted Therapies for BRAF Mutant Metastatic Melanoma -- Molecularly Targeted Therapy for Patients With BRAF Wild-type Melanoma -- Cytokines (IL-2, IFN GM-CSF etc) Melanoma -- Checkpoint Inhibitors in the Treatment of Metastatic Melanoma -- Novel Immunotherapies and Novel Combinations of Immunotherapy -- Managing Checkpoint Inhibitor Symtoms and Toxicity -- Sequencing and Combinations of Molecularly Targeted and Immunotherapy for BRAF-Mutant Melanoma -- Melanoma Vaccines -- Cellular Therapy for Melanoma -- Systemic Therapy for Mucosal, Acral and Uveal Melanoma -- Dermatological Complications of Systemic Therapies for Melanoma -- Surgical Management of Distant Melanoma Metastases -- Radiotherapy for Distant Metastases -- Melanoma Brain Metastases: Unique Biology and Implications for Systemic Therapy -- Part VIII. History of Melanoma -- A History of Melanoma: From Hunter to Morton.
Format
e-Book
Location
Online
Less detail

Osteoporosis : Pathophysiology and Clinical Management

https://libcat.nshealth.ca/en/permalink/provcat44861
Benjamin Z. Leder, Marc N. Wein, editors. (Third edition) --Cham: Humana Press , c2020.
Available Online
View e-Book
Location
Online
Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, …
Available Online
View e-Book
Other Authors
Leder, Benjamin Z.
Wein, Marc N.
Responsibility
Benjamin Z. Leder, Marc N. Wein, editors
Edition
Third edition
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2020
Physical Description
1 online resource (xv, 516 p.) : 82 illus., 46 illus. in color
Series
Contemporary Endocrinology
Series Title
Contemporary endocrinology
ISBN
9783319692876
9783319692869 (Print ed.)
9783319692883 (Print ed.)
ISSN
2523-3785
Subjects (MeSH)
Osteoporosis - physiopathology
Osteoporosis - therapy
Specialty
Osteology
Abstract
Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care. In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.
Contents
Basic Aspects of Osteoblast Function -- Basic Aspects of Osteoclast Differentiation and Function -- Basic Aspects of Osteocyte Function -- Vitamin D and Bone Health: Basic and Clinical Aspects -- Basic Aspects of Bone Mineralization -- Determinants of Peak Bone Mass Acquisition -- Osteoporosis Screening and Diagnosis -- New Imaging Techniques for Bone -- Biochemical Markers of Bone Turnover -- Biomechanics of Bone -- Exercise in the Prevention of Osteoporosis-Related Fractures -- Effects of Estrogens and SERMs on Bone Metabolism: Clinical Aspects -- The Effects of Androgens on Bone Metabolism: Clinical Aspects -- Bisphosphonates: Mechanisms of Action and Role in Osteoporosis Therapy -- Denosumab: Mechanisms and Therapeutic Effects in the Treatment of Osteoporosis -- The Parathyroid Hormone Receptor Type 1 -- PTH and PTHrP Analogs: Treatment of Osteoporosis -- Combination and Sequential Osteoanabolic/Antiresorptive Therapy in Osteoporosis Treatment -- Sclerostin Inhibition in the Treatment of Osteoporosis -- Osteoporosis in Men. Glucocorticoid-Induced Osteoporosis -- Transplantation Osteoporosis -- Osteoporosis in Premenopausal Women -- Safety Considerations for Osteoporosis Therapies -- Genetic Determinants and Pharmacogenetics of Osteoporosis and Osteoporotic Fracture.
Format
e-Book
Location
Online
Less detail

Atlas of Peculiar and Common Testicular and Paratesticular Tumors

https://libcat.nshealth.ca/en/permalink/provcat44957
Manuel Nistal, Pilar González-Peramato. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This book, conceived as an atlas with emphasis in diagnostic images, presents some tumors displaying expected clinical, histological or biological behavior but in most of them that differs from that usual morphology or clinical behaviour. About 132 tumors of the testicles and paratesticular structures have been selected, representing all the testicular and paratesticular tumor groups, including germinal, gonadal stromal, non-gonadal stromal, rete testis tumors, ovarian-type epithelial tumors, a…
Available Online
View e-Book
Author
Nistal, Manuel
Other Authors
González-Peramato, Pilar
Responsibility
Manuel Nistal, Pilar González-Peramato
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xii, 405 p.) : 1205 illus., 1185 illus. in color
ISBN
9783030196547
9783030196530 (Print ed.)
9783030196554 (Print ed.)
9783030196561 (Print ed.)
Subjects (MeSH)
Testicular Neoplasms - diagnosis
Testicular Neoplasms - pathology
Specialty
Medical Oncology
Men's Health
Reproductive Medicine
Abstract
This book, conceived as an atlas with emphasis in diagnostic images, presents some tumors displaying expected clinical, histological or biological behavior but in most of them that differs from that usual morphology or clinical behaviour. About 132 tumors of the testicles and paratesticular structures have been selected, representing all the testicular and paratesticular tumor groups, including germinal, gonadal stromal, non-gonadal stromal, rete testis tumors, ovarian-type epithelial tumors, and epididymis, spermatic cord and testicular covers as well as metastatic tumors. The format with large number of images allows pathologists to identify the entities included at a glance. Each section corresponds to one case including a brief clinical history, a concise histological description with immunohistochemical techniques necessary to confirm the diagnosis. In addition, each section provides several sample images, with histological details of the appropriate morphological or characteristic immunoexpression of diagnostic markers and in the majority of cases gross or radiologic figures. Finally, each section ends with a comment on the problems of differential diagnosis that could arise. The book is intended for pathologists, urologists and oncologists.
Contents
1. Germ Cell Tumors Derived from Germ Cell Neoplasia In Situ -- 2. Germ Cell Tumors Unrelated to Germ Cell Neoplasia In Situ -- 3. Sex Cord-Stromal Tumors -- 4. Tumors Containing Both Germ Cell and Sex Cord-Stromal Elements -- 5. Miscellaneous Tumors of the Testis -- 6. Hematolymphoid Tumors -- 7. Tumors of the Collecting Duct and Rete Testis -- 8. Tumors of Paratesticular Structures -- 9. Mesenchymal Tumors of the Spermatic Cord and Testicular Adnexa -- 10. Metastatic Tumors.
Format
e-Book
Publication Type
Atlas
Location
Online
Less detail

Occupational Cancers

https://libcat.nshealth.ca/en/permalink/provcat44971
Sisko Anttila, Paolo Boffetta, editors. (Second edition) --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This revised and updated new edition of a successful book is a multidisciplinary, comprehensive guide to occupational factors of malignant diseases. Building on the first edition, new research discoveries and their consequences in our understanding on carcinogenic mechanisms, diagnosis and attribution of occupational cancers are discussed. Examples of such discoveries are germline and acquired mutations of BAP1 in malignant mesothelioma, which have led to changes in diagnostic criteria, and car…
Available Online
View e-Book
Other Authors
Anttila, Sisko
Boffetta, Paolo
Responsibility
Sisko Anttila, Paolo Boffetta, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xv, 640 p.) : 79 illus., 54 illus. in color
ISBN
9783030307660
9783030307653 (Print ed.)
9783030307677 (Print ed.)
9783030307684 (Print ed.)
Subjects (MeSH)
Carcinogenesis - chemically induced
Occupational Diseases - epidemiology
Neoplasms - epidemiology
Neoplasms - etiology
Specialty
Medical Oncology
Occupational Health
Abstract
This revised and updated new edition of a successful book is a multidisciplinary, comprehensive guide to occupational factors of malignant diseases. Building on the first edition, new research discoveries and their consequences in our understanding on carcinogenic mechanisms, diagnosis and attribution of occupational cancers are discussed. Examples of such discoveries are germline and acquired mutations of BAP1 in malignant mesothelioma, which have led to changes in diagnostic criteria, and carcinogen-specific genetic and epigenetic alterations in lung cancer. There are several new chapters, including gastrointestinal cancers, epidemiology of lung cancer, cancer of thyroid, and the role of primary health care in occupational cancer control. Occupational Cancers is aimed at experienced and trainee oncologists, pathologists, clinicians in occupational health, and pulmonologists, as well as epidemiologists, clinical researchers, lawyers and public health officials.
Contents
1. Historical Overview of Occupational Cancer Research -- 2. Genetics, Epigenetics, and Environmental Interactions -- 3. Mechanisms of Environmental and Occupational Carcinogenesis -- 4. Head and Neck Cancers -- 5. Cancers of the Gastrointestinal Tract (Esophageal, Gastric, and Colorectal Cancer) -- 6. Pancreatic Cancer -- 7. Sinonasal Cancer -- 8. Cancers of the Intestine, the Liver, and the Biliary Tract -- 9. Occupational Risk Factors of Laryngeal Cancer -- 10. Lung Cancer: Clinical Findings, Pathology, and Exposure Assessment -- 11. Lung Cancer: Molecular Markers of Occupational Carcinogens -- 12. Lung Cancer: Mechanisms of Carcinogenesis by Asbestos -- 13. Lung Cancer: Mechanisms and Markers—Carcinogens Other Than Asbestos -- 14. Lung Cancer: Genetic Susceptibility -- 15. Epidemiology of Occupational Lung Cancer -- 16. Malignant Mesothelioma: Clinical and Imaging Findings -- 17. Malignant Mesothelioma: Pathology -- 18. Malignant Mesothelioma: Molecular Markers -- 19. Malignant Mesothelioma: Mechanism of Carcinogenesis -- 20. Malignant Mesothelioma: Asbestos Exposure -- 21. Epidemiology of Mesothelioma -- 22. Soft Tissue and Bone Sarcomas -- 23. Malignant Neoplasms of the Skin -- 24. Breast Cancer -- 25. Malignant Tumors of the Female Reproductive System -- 26. Malignant Tumours of the Male Reproductive System -- 27. Kidney Cancer -- 28. Bladder Cancer -- 29. Malignant Tumors of the Central Nervous System -- 30. Occupational Exposures and Thyroid Cancer -- 31. Lymphohematopoietic Malignancies -- 32. Occupational Cancer Burden -- 33. Occupational Carcinogens and Cancer in Children -- 34. Strategies for Primary Prevention of Occupational Cancer -- 35. Screening for Occupational Cancer -- 36. Occupational Cancer in the Practice of Occupational Medicine -- 37. The Use of Register Data in Occupational Cancer Control -- Appendix: Questionnaire on Exposure to Asbestos.
Format
e-Book
Location
Online
Less detail

Image Guided Dermatologic Treatments

https://libcat.nshealth.ca/en/permalink/provcat44984
Robert L. Bard, editor. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This book showcases the latest digital skin imaging, optical/laser systems and advanced immunologic therapies including topics ranging from the basic dermatologic sciences to advanced microscopic and laser optics. The addition of radiologic breakthroughs serves as comprehensive source for the dermatologic community, helping them access sonographic, CT, MRI and nuclear medicine procedures refined for dermatologic and subcutaneous pathologies. In addition, it assists radiologists determine the ap…
Available Online
View e-Book
Other Authors
Bard, Robert L.
Responsibility
Robert L. Bard, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xvii, 147 p.) : 161 illus., 146 illus. in color
ISBN
9783030292362
9783030292348 (Print ed.)
9783030292355 (Print ed.)
Subjects (MeSH)
Diagnostic Imaging - methods
Skin Diseases - diagnostic imaging
Skin Diseases - therapy
Ultrasonography - methods
Specialty
Dermatology
Abstract
This book showcases the latest digital skin imaging, optical/laser systems and advanced immunologic therapies including topics ranging from the basic dermatologic sciences to advanced microscopic and laser optics. The addition of radiologic breakthroughs serves as comprehensive source for the dermatologic community, helping them access sonographic, CT, MRI and nuclear medicine procedures refined for dermatologic and subcutaneous pathologies. In addition, it assists radiologists determine the appropriate imaging technologies for specific clinical dermal disorders. A detailed and up-to-date overview of image-guided treatments is provided. The initial chapters on benign and inflammatory diseases are precursors to advanced chapters on hidradenitis suppurativa and pigmented lesion analysis. A dedicated chapter on melanoma skin cancer and malignant melanoma is followed by updated concepts of melanoma treatment, including genetic markers and PET/CT to monitor therapeutic success. Further chapters address such topics as dermal trauma from foreign bodies and burns, scar imaging, fillers complications and podiatric imaging. Chapters on optical coherence tomography and reflectance confocal microscopy complete the coverage. All chapters were written by dermatologists trained in ultrasound diagnosis, interventional radiologists, dermatopathologists and specialists in advanced optical and microscopic dermatologic analysis, providing a reference guide to noninvasive diagnosis techniques and image guided minimally invasive treatment options. As such, Image Guided Dermatologic Treatments will be an invaluable asset for clinicians in medical and allied fields where dermatologic diagnosis using the least invasive option is required.
Contents
1. Advantages of Sonography of Benign Skin Diseases -- 2. Image guided Treatments in Skin Inflammatory Diseases -- 3. Ultrasound of Hidradentitis Suppurativa -- 4. Pigmented Melanocytic Tumors -- 5. Ultrasound Diagnosis of Non-melanoma Skin Cancer and Malignant Melanoma -- 6. Assessment of Efficacy of Systemic Therapy in Patients with Metastatic Melanoma -- 7. Dermal Trauma: Burns and Foreign Bodies -- 8. OCT Image Guided Treatment of Scars -- 9. Advantages of Sonography in Fillers and Complications -- 10. Podiatric Dermal Sonography -- 11. OCT guided Laser Treatment and Surgery -- 12. Reflectance Confocal Microscopy for the Diagnosis and Management of Skin Diseases.
Format
e-Book
Location
Online
Less detail

Glioma Imaging : Physiologic, Metabolic, and Molecular Approaches

https://libcat.nshealth.ca/en/permalink/provcat45019
Whitney B. Pope, editor. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). Thes…
Available Online
View e-Book
Other Authors
Pope, Whitney B.
Responsibility
Whitney B. Pope, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xiv, 286 p.) : 109 illus., 69 illus. in color
ISBN
9783030273590
9783030273583 (Print ed.)
9783030273606 (Print ed.)
9783030273613 (Print ed.)
Subjects (MeSH)
Glioma - diagnostic imaging
Neuroimaging - methods
Specialty
Diagnostic Imaging
Medical Oncology
Abstract
This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice. The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn: current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits.
Contents
1. Indications and Limitations of Conventional Imaging: Current Clinical Practice in the Context of Standard Therapy -- 2. Surrogates for Disease Status: Contrast Enhancement Including Limitations of Pseudoprogression and Pseudoresponse -- 3. The Relationship Between Biological and Imaging Characteristics in Enhancing and Nonenhancing Glioma -- 4. Contrast-Enhanced T1-Weighted Digital Subtraction for Increased Lesion Conspicuity and Quantifying Treatment Response in Malignant Gliomas -- 5. Advanced Physiologic Imaging: Perfusion. Theory and Applications -- 6. Advanced Physiologic Imaging: Diffusion. Theory and Applications -- 7. Parametric Response Map (PRM) Analysis Improves Response Assessment in Gliomas -- 8. Review of WHO 2016 Changes to Classification of Gliomas. Incorporation of Molecular Markers -- 9. Imaging Markers of Low Grade Diffuse Glioma -- 10. CEST, pH and Glucose Imaging as Markers for Hypoxia and Malignant Transformation -- 11. MRS for D-2HG Detection in IDH Mutant Glioma -- 12. C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain Tumors -- 13. FET and FDOPA PET Imaging in Glioma -- 14. Imaging Genomics -- 15. Radiomics and Machine Learning -- 16. Immunotherapy and Gliomas -- 17. The Path Forward –The Standardized Brain Tumor Imaging Protocol (BTIP) for Multicenter Trials.
Format
e-Book
Location
Online
Less detail

Stress Challenges and Immunity in Space : From Mechanisms to Monitoring and Preventive Strategies

https://libcat.nshealth.ca/en/permalink/provcat45093
Alexander Choukèr, editor. (Second edition) --Cham: Springer , c2020.
Available Online
View e-Book
Access
Open access
Location
Online
This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on imm…
Available Online
View e-Book
Other Authors
Choukèr, Alexander
Responsibility
Alexander Choukèr, editor
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xvi, 771 p.) : 137 illus., 112 illus. in color
ISBN
9783030169961
9783030169954 (Print ed.)
9783030169978 (Print ed.)
9783030169985 (Print ed.)
Subjects (MeSH)
Aerospace Medicine
Immunity - physiology
Space Flight
Stress, Physiological - physiology
Specialty
Aerospace Medicine
Abstract
This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Contents
Part I. Introduction -- 1. The Human Space Exploration Endeavour: A Personal View from Inside -- 2. Space Travel: A Personal View from Above -- 3. Entering a New Era of Holistic Research in Establishing Groundwork for Future Human Space Exploration: Perspectives from the ESA-Topical Team “Stress and Immunity” -- Part II. Stress and Immunity Research: A Link Between Space and Earth -- 4. What Is Stress? -- 5. Environmental Stress: Mitochondria as Targets and Stressors in Cellular Metabolism -- 6. The Impact of Everyday Stressors on the Immune System and Health -- Part III. Stress and Immune Allostasis in Space, from Brain to Immune Responses -- 7. Neurobiological Mechanisms of Stress and Glucocorticoid Effects on Learning and Memory: Implications for Stress Disorders on Earth and in Space -- 8. The Autonomic Nervous System -- 9. Circadian Rhythm and Stress -- 10. Endocannabinoids, “New-Old” Mediators of Stress Homeostasis -- 11. Immune System in Space: General Introduction and Observations on Stress-Sensitive Regulations -- 12. Innate Immunity Under the Exposome of Space Flight -- 13. NK Cell Assessments: A 40-Years-Old History of Immune–Stress Interaction in Space with a Promising Future -- 14. Adaptive Immunity and Spaceflight -- 15. B-Cell Immunology in Space -- 16. Stress, Hypoxia, and Immune Responses -- 17. Cellular and Molecular Responses to Gravitational Force-Triggered Stress in Cells of the Immune System -- 18. Microbial Stress: Spaceflight-Induced Alterations in Microbial Virulence and Infectious Disease Risks for the Crew -- 19. Stress, Spaceflight, and Latent Herpes Virus Reactivation -- 20. Stress and Radiation Responsiveness -- Part IV. Preventive and Diagnostic Tool and Strategies -- 21. Considerations for Development and Application of Health Monitoring Tools in Space -- 22. Psychological Monitoring -- 23. Monitoring of Autonomic Activity by Cardiovascular Variability: How to Measure? -- 24. Breath Gas Analysis -- 25. Monitoring the Microbial Burden in Manned Space Stations -- 26. Monitoring of Core Body Temperature in Humans -- 27. Flow Cytometry Methods to Monitor Immune Dysregulation Associated with Spaceflight -- 28. Assessment of Radiosensitivity and Biomonitoring of Exposure to Space Radiation -- 29. Analytical Approaches to the Quantitative Evaluation of Endocannabinoids and Glucocorticoids as Stress Markers: Growing Evidence for Hair Testing -- Part V.. Therapeutic Strategies -- 30. Preventive and Therapeutic Strategies to Counter Immune System Dysfunctioning During Spaceflight -- 31. Psychological Countermeasures -- 32. Physical Countermeasures to Stress -- 33. Nutritional Countermeasures for Spaceflight-Related Stress -- 34. Microbiome and Immunity: A Critical Link for Long-Duration Space Exploration Missions -- 35. Pharmacological Countermeasures to Spaceflight-Induced Alterations of the Immune System -- Part VI. Perspectives for Manned Space Exploration—from Visions to Realities -- 36. Platforms for Stress and Immune Research in Preparation for Long-Duration Space Exploration Missions -- 37. Mars500: The First Preparation of Long-Duration Space Exploration Missions—Results and Implications for a Holistic Stress and Immune Research Approach -- 38. Exploration Class Missions on Earth: Lessons Learnt from Life in Extreme Antarctic Isolation and Confinement -- 39. Moon, Mars and Beyond -- Part VII. Synopsis -- 40. Summary and Outlook.
Access
Open access
Format
e-Book
Location
Online
Less detail

Mastocytosis : A Comprehensive Guide

https://libcat.nshealth.ca/en/permalink/provcat45102
Cem Akin, editor. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This unique book offers an in-depth, best-practices guide to diagnosis and management of mastocytosis, a too-often underdiagnosed disease. Mastocytosis: A Comprehensive Guide will open with a general overview and discussion of mast cell biology, addressing tryptase and other diagnostic markers in detail. Comprehensive diagnostic criteria and classification will follow, with special emphasis on commonly-seen related manifestations: skin disease, pediatric mastocytosis, gastrointestinal indicator…
Available Online
View e-Book
Other Authors
Akin, Cem
Responsibility
Cem Akin, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xii, 307 p.) : 60 illus., 58 illus. in color
ISBN
9783030278205
9783030278199 (Print ed.)
9783030278212 (Print ed.)
9783030278229 (Print ed.)
Subjects (MeSH)
Mastocytosis - diagnosis
Mastocytosis - therapy
Specialty
Gynecology
Abstract
This unique book offers an in-depth, best-practices guide to diagnosis and management of mastocytosis, a too-often underdiagnosed disease. Mastocytosis: A Comprehensive Guide will open with a general overview and discussion of mast cell biology, addressing tryptase and other diagnostic markers in detail. Comprehensive diagnostic criteria and classification will follow, with special emphasis on commonly-seen related manifestations: skin disease, pediatric mastocytosis, gastrointestinal indicators, osteoporosis, anaphylaxis, venom and drug allergy, and pregnancy. Mastocytosis will be an ideal resource for not only the allergist confronted with this condition, but for a growing, multi-disciplinary audience of hematologists, gastroenterologists, dermatologists, pediatricians, primary care providers and other clinicians who encounter this disease in their patients.
Contents
1. Overview of Mast Cells in Human Biology -- 2. Mastocytosis: Overview of Diagnosis and Classification -- 3. Clinical Approach to a Patient with Elevated Serum Tryptase: Implications of Acute Versus Basally Elevated Levels -- 4. Urinary Markers of Mast Cell Disease and Their Role in Diagnosis and Management -- 5. Skin Disease in Mastocytosis -- 6. Pediatric Mastocytosis -- 7. Gastrointestinal Manifestations of Systemic Mastocytosis -- 8. Systemic Mastocytosis and Bone-Related Events -- 9. Anaphylaxis in Mastocytosis -- 10. Venom Allergy and Management in Mastocytosis -- 11. Drug Allergy and Perioperative Management of Mastocytosis -- 12. Mastocytosis in Pregnancy -- 13. KIT and Other Mutations in Mastocytosis -- 14. Management of Hematologic Disease in Mastocytosis -- 15. Tyrosine Kinase Inhibitors in Systemic Mastocytosis -- 16. International Support and Advocacy for Mast Cell Disease Patients and Caregivers -- 17. History and Current Status of Mastocytosis Research in the European Competence Network on Mastocytosis.
Format
e-Book
Location
Online
Less detail

Parathyroid Glands in Chronic Kidney Disease

https://libcat.nshealth.ca/en/permalink/provcat45256
Adrian Covic, David Goldsmith, Pablo A. Ureña Torres, editors. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This concise book provides practical strategies to help nephrologists and endocrinologists correctly diagnose and treat the various forms of parathyroid disease they may encounter in the management of chronic kidney disease. Each chapter deals with various topics related to parathyroid gland anatomy and physiology, as well as diagnostic tests and their particularities in regard to chronic disease. The book highlights the range of therapies used for the treatment of secondary hyperparathyroidism…
Available Online
View e-Book
Other Authors
Covic, Adrian
Goldsmith, David
Ureña Torres, Pablo A.
Responsibility
Adrian Covic, David Goldsmith, Pablo A. Ureña Torres, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (vi, 196 p.) : 21 illus., 18 illus. in color
ISBN
9783030437695
9783030437688 (Print ed.)
9783030437701 (Print ed.)
9783030437718 (Print ed.)
Subjects (MeSH)
Parathyroid Glands - physiopathology
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
Specialty
Endocrinology
Nephrology
Abstract
This concise book provides practical strategies to help nephrologists and endocrinologists correctly diagnose and treat the various forms of parathyroid disease they may encounter in the management of chronic kidney disease. Each chapter deals with various topics related to parathyroid gland anatomy and physiology, as well as diagnostic tests and their particularities in regard to chronic disease. The book highlights the range of therapies used for the treatment of secondary hyperparathyroidism, and critically analyses the latest research in the field. Providing an up-to-date review of the current literature, including innovations in both medical and surgical treatment and current indications for parathyroidectomy, this practice-oriented book is an excellent resource for nephrologists, endocrinologists, endocrine surgeons and family medicine physicians.
Contents
Parathyroid Glands in CKD: Anatomy, Histology, Physiology and Molecular Biology in CKD -- PTH Regulation by the Klotho/FGF23 Axis in CKD -- Parathyroid Imaging in Patients with Renal Hyperparathyroidism -- PTH Receptors and Skeletal Resistance to PTH Action -- PTH Regulation by Phosphate and miRNAs -- PTH Measurement in CKD -- Relation Between PTH and Biochemical Markers of MBD -- Effect of PTH on the Hematologic System -- Parathyroid Hormone as a Uremic Toxin -- Control of Secondary Hyperparathyroidism (SPHT) by Older and Newer Vitamin D Compounds -- The Role of the Old and the New Calcimimetic Agents in Chronic Kidney Disease-Mineral and Bone Disorder -- Parathyroidectomy in Chronic Kidney Disease -- Relation Between PTH and the Risk of Mortality in CKD.
Format
e-Book
Location
Online
Less detail

Interventional Ultrasound of the Breast : From Biopsy to Ablation

https://libcat.nshealth.ca/en/permalink/provcat45314
Bruno D. Fornage. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This book is the premier guide to ultrasound-guided interventions of the breast. Written by Bruno D Fornage, a world-renowned leader in the fields of breast ultrasound and ultrasound-guided interventions, it covers in detail techniques of freehand ultrasound-guided breast biopsy, placement of post-biopsy markers, localization of nonpalpable lesions, and percutaneous ablation of breast masses. A large part of the book describes the highly effective combined use of fine-needle aspiration and core…
Available Online
View e-Book
Author
Fornage, Bruno D.
Responsibility
Bruno D. Fornage
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xviii, 460 p.) : 642 illus., 488 illus. in color
ISBN
9783030208295
9783030208271 (Print ed.)
9783030208288 (Print ed.)
Subjects (MeSH)
Biopsy, Fine-Needle
Breast - diagnostic imaging
Image-Guided Biopsy
Ultrasonography, Mammary - methods
Specialty
Gynecology
Surgical Oncology
Ultrasonography
Abstract
This book is the premier guide to ultrasound-guided interventions of the breast. Written by Bruno D Fornage, a world-renowned leader in the fields of breast ultrasound and ultrasound-guided interventions, it covers in detail techniques of freehand ultrasound-guided breast biopsy, placement of post-biopsy markers, localization of nonpalpable lesions, and percutaneous ablation of breast masses. A large part of the book describes the highly effective combined use of fine-needle aspiration and core-needle biopsy during the staging of breast cancer; this combination has been used successfully by the author at MD Anderson Cancer Center for 3 decades. Throughout the book, the author shares numerous tips and tricks, many of which have not been published before. With over 1300 figures and and 200 videoclips depicting ultrasound-guided procedures, Interventional Ultrasound of the Breast is the authoritative resource for breast imagers, interventional radiologists, surgical breast oncologists, pathologists, and anyone who embarks on ultrasound-guided breast biopsies and other breast procedures. In addition, the techniques described in this book are applicable to many other areas of the body, including the thyroid and soft tissues.
Contents
1. Equipment for Breast Ultrasound -- 2. Basic Breast Ultrasound Examination Technique - 3. General Considerations in Ultrasound-Guided Percutaneous Needle Biopsies -- 4. Preparing for Ultrasound-Guided Biopsy -- 5. Basic Needle Insertion Techniques -- 6. Fine-Needle Aspiration -- 7. Fine-Needle Aspiration of Cysts and Other Fluid Collections -- 8. Fine-Needle Aspiration of Solid Masses -- 9. Fine-Needle Aspiration in Breast Cancer Staging -- 10. Advantages and Limitations of Ultrasound-Guided Fine-Needle Aspiration -- 11. Errors and Pitfalls in Ultrasound-Guided Fine-Needle Aspiration -- 12. Core-Needle Biopsy -- 13. Vacuum-Assisted Biopsy -- 14. Choosing the Biopsy Technique -- 15. Biopsy Markers -- 16. Complications of Percutaneous Needle Biopsy -- 17. What Not to Biopsy -- 18. Keys to Success in Ultrasound-Guided Breast Biopsy -- 19. Ultrasound-Guided Localization of Nonpalpable Lesions -- 20. Other Ultrasound-Guided Interventional Procedures -- 21. Percutaneous Ablation of Breast Masses.
Format
e-Book
Location
Online
Less detail

Molecular Targeted Radiosensitizers : Opportunities and Challenges

https://libcat.nshealth.ca/en/permalink/provcat45329
Henning Willers, Iris Eke, editors. --Cham: Humana Press , c2020.
Available Online
View e-Book
Location
Online
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying …
Available Online
View e-Book
Other Authors
Willers, Henning
Eke, Iris
Responsibility
Henning Willers, Iris Eke, editors
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2020
Physical Description
1 online resource (xi, 364 p.) : 42 illus., 38 illus. in color
Series Title
Cancer drug discovery and development
ISBN
9783030497019
9783030497002 (Print ed.)
9783030497026 (Print ed.)
9783030497033 (Print ed.)
ISSN
2196-9906
Subjects (MeSH)
Molecular Medicine
Neoplasms - radiotherapy
Radiation-Sensitizing Agents
Radiotherapy - methods
Specialty
Medical Oncology
Pharmacology
Radiotherapy
Abstract
Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
Contents
Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges -- Translating Targeted Radiosensitizers into the Clinic -- Mapping the Radiogenome of Human Cancers -- Mechanisms and Markers of Clinical Radioresistance -- Preclinical Strategies for Testing of Targeted Radiosensitizers -- 3D Radiation Biology for Identifying Radiosensitizers -- Preclinical In Vivo Evaluation of Novel Radiosensitizers by Local Tumor Control Experiments -- Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers -- Targeting the DNA Damage Response for Radiosensitization -- Targeting Tumor Metabolism to Overcome Radioresistance -- Targeting Tumor Hypoxia -- Normalizing the Tumor Microenvironment for Radiosensitization -- Radiosensitizers in the Era of Immuno-Oncology.
Format
e-Book
Location
Online
Less detail

Sleep Disorders in Parkinson’s Disease : Management and Case Study

https://libcat.nshealth.ca/en/permalink/provcat45367
Chun-Feng Liu, editor. --Singapore: Springer , c2020.
Available Online
View e-Book
Location
Online
This book focuses on the sleep-related disorders in Parkinson's disease (PD), demonstrating that they are among the most common non-motor manifestations of PD and have a significant negative impact on quality of life. Sleep changes may also serve as markers to identify patients in the preclinical stage of PD. This book presents recent major breakthroughs related to sleep disorders in PD, such as REM sleep behavior disorder (RBD), insomnia, nocturia, restless legs syndrome and periodic limb move…
Available Online
View e-Book
Other Authors
Liu, Chun-Feng
Responsibility
Chun-Feng Liu, editor
Place of Publication
Singapore
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (ix, 105 p.) : 16 illus., 14 illus. in color
ISBN
9789811524813
9789811524806 (Print ed.)
9789811524820 (Print ed.)
9789811524837 (Print ed.)
Subjects (MeSH)
Parkinson Disease - complications
Sleep Wake Disorders
Specialty
Neurology
Sleep Medicine Specialty
Abstract
This book focuses on the sleep-related disorders in Parkinson's disease (PD), demonstrating that they are among the most common non-motor manifestations of PD and have a significant negative impact on quality of life. Sleep changes may also serve as markers to identify patients in the preclinical stage of PD. This book presents recent major breakthroughs related to sleep disorders in PD, such as REM sleep behavior disorder (RBD), insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. It also discusses the epidemiology, etiology, diagnosis, clinical implications, associated features, evaluation and management of these disorders and suggests some further research directions in these areas in order to develop neuroprotective therapies for PD. Focusing on Chinese PD patients, it addresses traditional Chinese Medicine, and compares the epidemiology and management of PD in China and Western countries to provide a frame of reference values for further studies. Further, it features numerous case reports to enable readers gain a better uderstanding of the subject matter. This comprehensive yet practical book is a valuable resource for scientists and clinicians.
Contents
Part I. General Concepts -- 1. An Overview of Parkinson’s Disease -- 2. An Overview of Roles of the Basal Ganglia in Sleep-Wake Regulation -- Part II. Classification of Sleep Disorders in Parkinson’s Disease -- 3. REM Sleep Behavior Disorder (RBD) -- 4. Insomnia -- 5. Nocturia -- 6. Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder -- 7. Sleep-Related Breathing Disorders -- 8. Excessive Daytime Sleepiness -- 9. Circadian Rhythms Disruption -- 10. Conclusive Remarks.
Format
e-Book
Location
Online
Less detail

Tumor Microenvironment

https://libcat.nshealth.ca/en/permalink/provcat45390
Peter P. Lee, Francesco M. Marincola, editors. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therap…
Available Online
View e-Book
Other Authors
Lee, Peter P.
Marincola, Francesco M.
Responsibility
Peter P. Lee, Francesco M. Marincola, editors
Alternate Title
Tumour microenvironment
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxiv, 326 p.) : 61 illus., 56 illus. in color
Series Vol.
180
Series Title
Cancer treatment and research
ISBN
9783030388621
9783030388614 (Print ed.)
9783030388638 (Print ed.)
9783030388645 (Print ed.)
ISSN
0927-3042
Subjects (MeSH)
Neoplasms - immunology
Tumor Microenvironment
Specialty
Medical Oncology
Pathology
Abstract
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Contents
Part I. Imaging of Tumor Microenvironment -- 1. Functional In Vivo Imaging of Tumors -- 2. New Technologies to Image Tumors -- Part II. Immune Landscapes and Their Biology -- 3. Systemic Correlates of the Tumor Microenvironment -- 4. Adaptive Immunity and the Tumor Microenvironment -- 5. The Biology of Immune-Active Cancers and Their Regulatory Mechanisms -- 6. The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier -- 7. The Role of the Immune Infiltrate in Distinct Cancer Types and Its Clinical Implications -- Part III. The Tumor Microenvironment and Therapy -- 8. The Immune Landscape in Women Cancers -- 9. Translational Biomarkers and Rationale Strategies to Overcome Resistance to Immune Checkpoint Inhibitors in Solid Tumors -- 10. Immunogenic Cell Death Driven by Radiation—Impact on the Tumor Microenvironment -- 11. CAR T Cell Therapy Progress and Challenges for Solid Tumors.
Format
e-Book
Location
Online
Less detail

Articular Cartilage of the Knee : Health, Disease and Therapy

https://libcat.nshealth.ca/en/permalink/provcat45489
Harpal K. Gahunia, Allan E. Gross, Kenneth P.H. Pritzker, Paul S. Babyn, Lucas Murnaghan, editors. --New York, NY: Springer , c2020.
Available Online
View e-Book
Location
Online
Covering both pediatric and adult populations, this comprehensive text covers the diverse topics related to the health, disease and therapy of articular cartilage of the knee, from basic principles to future directions for research. This vast array of information is arranged into eight sections, encompassing a number of relevant disciplines and covering, in turn, normal articular cartilage, aging and degeneration, evaluation and assessment, non-surgical approaches, surgical approaches, qualitat…
Available Online
View e-Book
Other Authors
Gahunia, Harpal K.
Gross, Allan E.
Pritzker, Kenneth P.H.
Babyn, Paul S.
Murnaghan, Lucas
Responsibility
Harpal K. Gahunia, Allan E. Gross, Kenneth P.H. Pritzker, Paul S. Babyn, Lucas Murnaghan, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxxviii, 498 p.) : 145 illus., 85 illus. in color
ISBN
9781493975877
9781493975853 (Print ed.)
9781493975860 (Print ed.)
Subjects (MeSH)
Cartilage, Articular - physiology
Knee Joint - physiology
Knee Joint - surgery
Specialty
Orthopedics
Abstract
Covering both pediatric and adult populations, this comprehensive text covers the diverse topics related to the health, disease and therapy of articular cartilage of the knee, from basic principles to future directions for research. This vast array of information is arranged into eight sections, encompassing a number of relevant disciplines and covering, in turn, normal articular cartilage, aging and degeneration, evaluation and assessment, non-surgical approaches, surgical approaches, qualitative and quantitative assessment of repair, research into cartilage repair and engineering, and future prospects for therapy. Each chapter is amply referenced and self-contained for independent study and reference. Scoring systems for knee cartilage assessment are included in four appendices as well, rounding out the presentation. A multidisciplinary collection of basic, translational and clinical material, Articular Cartilage of the Knee is a singular resource for orthopedic surgeons, rheumatologists, pathologists, scientists, tissue engineers and the broad spectrum of clinical professionals working with articular cartilage and its disorders.
Contents
Part I. Normal Articular Cartilage -- Structure and Function of Articular Cartilage -- Growth and Development of Articular Cartilage -- Part II. Aging, Degeneration and Physiologic Articular Cartilage Healing -- Articular Cartilage: Homeostasis, Aging and Degeneration -- Articular Cartilage Degradation: Biochemical Markers and Dynamic Loading -- Part III. Knee Articular Cartilage Injury: Evaluation and Assessment -- Acute and Chronic Traumatic Cartilage Injuries of the Knee -- Diagnostic Imaging of Knee Cartilage Injury: Evaluation and Assessment -- Assessment of Knee Cartilage Injury: Arthroscopic Evaluation and Classification -- Part IV. Repair of Knee Articular Cartilage Injury: Non-Operative Approach -- Physical and Rehabilitative Therapy for Knee Cartilage Injury and Disease -- Pharmacologic Agents for Knee Articular Cartilage Injury and Disease -- Part V. Repair of Knee Articular Cartilage: Surgical Approach -- Osteochondritis Dissecans of the Knee: Pathophysiology and Treatment -- Surgical Approach to Articular Cartilage Repair -- Clinical Outcome Assessment of Repaired Articular Cartilage -- Part VI. Qualitative and Quantitative Assessment of Articular Cartilage Repair -- Pre- and Post-Operative Imaging of Knee Articular Cartilage -- MRI of the Ultrastructural Composition of Articular Cartilage in Disease and Repair -- Histopathological Evaluation of Articular Cartilage Disease and Repair -- Part VII. Research in Cartilage Repair and Cartilage Engineering Strategies -- Human Derived Cells in Chondral or Osteochondral Repair -- Relevance of Engineered Scaffolds for Cartilage Repair -- Commercially Available Bio-Engineered Cartilage Grafts -- Part VIII. Future Prospects for Knee Articular Cartilage Therapy -- Knee Articular Cartilage: Future Directions for Research and Practice.
Format
e-Book
Location
Online
Less detail

Practical Immunocytochemistry in Diagnostic Cytology

https://libcat.nshealth.ca/en/permalink/provcat45580
Eugenio Leonardo, Ricardo H. Bardales. --Cham: Springer , c2020.
Available Online
View e-Book
Location
Online
This book provides current information for a judicious use of conventional and molecular ICC markers performed in cytologic samples to help in the cost-effective diagnosis of superficial and deep-seated masses. By providing both an eminently practical information for appropriate technical preparation of cytologic samples and a systematic exposure of the immunophenotypic and biomolecular characteristics of normal and pathological cells, the reported morphological-molecular findings highlight the…
Available Online
View e-Book
Author
Leonardo, Eugenio
Other Authors
Bardales, Ricardo H.
Responsibility
Eugenio Leonardo, Ricardo H. Bardales
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xv, 174 p.) : 484 illus. in color
ISBN
9783030466565
9783030466558 (Print ed.)
9783030466572 (Print ed.)
9783030466589 (Print ed.)
Subjects (MeSH)
Cytodiagnosis
Immunohistochemistry
Neoplasms - diagnosis
Specialty
Cell Biology
Diagnosis
Clinical Laboratory Techniques
Abstract
This book provides current information for a judicious use of conventional and molecular ICC markers performed in cytologic samples to help in the cost-effective diagnosis of superficial and deep-seated masses. By providing both an eminently practical information for appropriate technical preparation of cytologic samples and a systematic exposure of the immunophenotypic and biomolecular characteristics of normal and pathological cells, the reported morphological-molecular findings highlight the characteristics of different lesions that are useful for the practical solution of a particular differential diagnosis. Chapters include description of the cytomorphology followed by a practical ICC staining pattern for each entity. Cytologic materials include serous effusions, exfoliative cytology, fine needle aspiration cytology of superficial and deep-seated masses, and squash preparation from central nervous system masses. Practical Immunocytochemistry in Diagnostic Cytology serves as a valuable resource towards understanding critical differences between tests performed on tissue samples and those carried out on cytologic samples.
Contents
Immunocytochemistry: Technical Considerations Applied to Cytology -- Serous Effusions -- Exfoliative Cytology -- Aspiration Cytology of Masses of Superficial Organs -- Aspiration Cytology of Deep-Seated Masses -- Pitfalls in Immunocytochemistry.
Format
e-Book
Location
Online
Less detail

Follicular Lymphoma and Mantle Cell Lymphoma : Pathobiology, Diagnosis and Treatment

https://libcat.nshealth.ca/en/permalink/provcat45629
Prabhjot Kaur, editor. --Cham: Humana Press , c2020.
Available Online
View e-Book
Location
Online
The book is dedicated to follicular lymphoma and mantle cell lymphoma and highlights major reference works that contributed significantly to the understanding of these two lymphomas. The aim is to bring the basic science adjacent to the applied science. There is significant focus on the biology of normal B cell development that forms the basis for understanding the pathobiology of these entities. This text is designed to provide a concise yet comprehensive summary of traditional and newer entit…
Available Online
View e-Book
Other Authors
Kaur, Prabhjot
Responsibility
Prabhjot Kaur, editor
Place of Publication
Cham
Publisher
Humana Press
Date of Publication
c2020
Physical Description
1 online resource (ix, 183 p.) : 40 illus. in color
Series Title
Molecular and translational medicine
ISBN
9783030497415
9783030497408 (Print ed.)
9783030497422 (Print ed.)
9783030497439 (Print ed.)
ISSN
2197-7852
Subjects (MeSH)
Lymphoma, Follicular
Lymphoma, Mantle-Cell
Subjects (LCSH)
Pathology
Hematology
Oncology  
Specialty
Hematology
Medical Oncology
Abstract
The book is dedicated to follicular lymphoma and mantle cell lymphoma and highlights major reference works that contributed significantly to the understanding of these two lymphomas. The aim is to bring the basic science adjacent to the applied science. There is significant focus on the biology of normal B cell development that forms the basis for understanding the pathobiology of these entities. This text is designed to provide a concise yet comprehensive summary of traditional and newer entities, prognostic markers, pathobiology and newer classifications based on molecular genetics/chromosomal abnormalities. The chapters are written by practicing hematopathologists, molecular pathologists, dermatopathologists and clinical haematologists with an emphasis on practical approaches to these entities. The newer technologies and their practical applications are elaborated in an easy-to-comprehend format. Follicular Lymphoma and Mantle Cell Lymphoma is an approachable read for residents and fellows and clinically relevant to practicing pathologists and hematologists. It also serves as a valuable resource for anyone with an interest in B cell lymphomas.
Contents
1. Follicular Lymphoma: Definition, Epidemiology, Pathobiology – Lymphomagenesis, Morphology, Variants, Immunophenotype, Prognostic Factors, Transformation -- 2. Mantle Cell Lymphoma: Definition, Epidemiology, Pathobiology – Lymphomagenesis, Morphology, Variants, Immunophenotype, Prognostic Factors -- 3. Primary Cutaneous B-cell Lymphomas: FL, MCL, Differential Diagnosis -- 4. Follicular and Mantle Cell Lymphomas: Technical and Interpretive Considerations; Karyotyping, FISH, Chromosomal Microarray, Sequencing, B Cell Clonality, Minimal Residual Disease -- 5. Follicular Lymphoma: Therapeutics and Management -- 6. Mantle Cell Lymphoma: Therapeutics and Management.
Format
e-Book
Location
Online
Less detail

176 records – page 1 of 9.