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Advanced concepts in surgical research

https://libcat.nshealth.ca/en/permalink/provcat33095
edited by Mohit Bhandari, Bernd Robioneck ; associate editor, Emil Schemitsch ; managing editor, Sheila Sprague ; with contributions by Volker Alt ... [et al.]. --Stuttgart: Thieme , c2012.
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Online
Advanced Concepts in Surgical Research is a practical, reader-friendly guide to planning, conducting, and evaluating solid, evidence-based surgical research that leads to high-quality results. Geared to the investigator who has already mastered basic principles, this book focuses on more advanced topics such as randomized controlled trials, survey design, observational studies, meta analyses, statistical concepts, reporting of data, and much more.
Available Online
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Other Authors
Bhandari, Mohit
Robioneck, Bernd
Schemitsch, Emil H.
Sprague, Sheila
Alt, Volker
Responsibility
edited by Mohit Bhandari, Bernd Robioneck ; associate editor, Emil Schemitsch ; managing editor, Sheila Sprague ; with contributions by Volker Alt ... [et al.]
Place of Publication
Stuttgart
Publisher
Thieme
Date of Publication
c2012
Physical Description
1 online resource (xiv, 225 p.)
ISBN
9783131658111
9783131670212 (eISBN)
Subjects (MeSH)
Biomedical Research - methods
Clinical Trials as Topic
General Surgery
Research Design
Statistics as Topic
Specialty
General Surgery
Research
Abstract
Advanced Concepts in Surgical Research is a practical, reader-friendly guide to planning, conducting, and evaluating solid, evidence-based surgical research that leads to high-quality results. Geared to the investigator who has already mastered basic principles, this book focuses on more advanced topics such as randomized controlled trials, survey design, observational studies, meta analyses, statistical concepts, reporting of data, and much more.
Format
e-Book
Location
Online
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Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation

https://libcat.nshealth.ca/en/permalink/provcat46376
Zoka Milan, Chula Goonasekera, editors. --Cham: Springer , c2021.
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Access
NEW Springer 2021
Location
Online
This concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved…
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Other Authors
Milan, Zoka
Goonasekera, Chula
Responsibility
Zoka Milan, Chula Goonasekera, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2021
Physical Description
1 online resource (vii, 475 p.) : 88 illus., 80 illus. in color
ISBN
9783030513313
9783030513306 (Print ed.)
9783030513320 (Print ed.)
9783030513337 (Print ed.)
Subjects (MeSH)
Anesthesia - methods
Liver - surgery
Liver Transplantation - methods
Pancreas - surgery
Perioperative Care
Specialty
Anesthesiology
Gastroenterology
Surgical Procedures, Operative
Abstract
This concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved in terms of blood-loss reduction, fast tracking and reduced risk. The book also addresses anesthetic aspects in connection with the recently introduced and rapidly expanding practice of laparoscopic surgery; with enhanced recovery; and with pancreatic surgery. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation is intended for aspiring HPB and transplant anesthetists, anesthesia trainees, and consultants with experience in HPB anesthesia who want to see whether or not they’re up to date on the current standards.
Contents
Part I. Anatomy and Physiology of the Liver -- 1. Anatomy of Hepato-Pancreato-Biliary Surgery and Liver Transplantation -- 2. Anatomy and Physiology of the Liver -- Part II. Liver Transplantation -- 3. Pathophysiology Behind Cardiopulmonary Complications of Cirrhosis and Portal Hypertension -- 4. Liver Transplantation: Graft Variables -- 5. Surgical Aspects of Liver Transplantation -- 6. Pre-assessment for Hepato-Pancreato-Biliary and Liver Transplant Surgery -- 7. The Role of Cardiopulmonary Exercise Testing (CPET) in the Preoperative Assessment of Patients for Hepatico-Pancreatic-Biliary (HPB) Surgery and Liver Transplantation (LT) -- 8. Anaesthesia for Liver Transplantation -- 9. How Does the Aetiology of Primary Liver Disease Affect Anaesthesia for Liver Transplantation -- 10. Haemodynamic Monitoring During Liver Transplant Surgery -- 11. Point of Care Viscoelastic Haemostasis Monitoring During Liver Transplant Surgery -- 12. How to Reduce Bleeding and Blood Transfusion During Liver Transplantation -- 13. Fast Tracking in a Liver Transplant Programme -- 14. Acute Kidney Injury in Hepatico-Pancreatic-Biliary Surgery and Liver Transplantation -- 15. Use of Extracorporeal Membrane Oxygenation During Liver Transplantation -- 16. Liver Preservation with Extracorporeal Perfusion -- 17. Veno-Venous Bypass in Liver Transplantation -- Part III. Liver Resection -- 18. Biology of Liver Tumors and Outcomes of Liver Surgery -- 19. Anaesthesia for Live Donor Hepatectomy -- 20. Strategies for Low Central Venous Pressure in Liver Resection Surgery -- 21. Enhanced Recovery After HPB Surgery -- 22. Postoperative Analgesia in Liver Resection Surgery -- Part IV. Pancreas -- 23. Surgical Aspects of Hepato-Pancreato-Biliary Surgery -- 24. Perioperative Anaesthetic Considerations for the Whipple Procedure and Other Pancreatic Surgeries -- 25. Anaesthetic Management for Patients Undergoing Pancreas Transplantation -- Part V. Paediatric -- 26. Anaesthesia for Paediatric HPB Surgery -- 27. Anaesthesia for Paediatric Liver Transplantation -- 28. Communication Between HPB Anaesthetists: Meetings, Websites and Forums.
Access
NEW Springer 2021
Format
e-Book
Location
Online
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Assembling the pieces of a systematic review : a guide for librarians

https://libcat.nshealth.ca/en/permalink/provcat52816
Foser, Margaret J. Medical Library Association. --Lanham, MD: Rowman & Littlefield , 2017.
Call Number
W 20.5 A844 2017
Location
IWK Health Sciences Library
Call Number
W 20.5 A844 2017
Author
Foser, Margaret J.
Corporate Author
Medical Library Association
Other Authors
Newell, Sarah T.
Place of Publication
Lanham, MD
Publisher
Rowman & Littlefield
Date of Publication
2017
Physical Description
226 p.
ISBN
9.78E+12
Subjects (MeSH)
Review Literature as Topic
Meta-Analysis as Topic
Research
Databases, Bibliographic
Format
Book
Location
IWK Health Sciences Library
Copies
1
Loan Period
2 weeks
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Basic Methods Handbook for Clinical Orthopaedic Research : A Practical Guide and Case Based Research Approach

https://libcat.nshealth.ca/en/permalink/provcat44122
Volker Musahl, Jón Karlsson, Michael T. Hirschmann, Olufemi R. Ayeni, Robert G. Marx, Jason L. Koh, Norimasa Nakamura, editors. --Berlin, Heidelberg: Springer , 2019.
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Online
This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies…
Available Online
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Other Authors
Musahl, Volker
Karlsson, Jón
Hirschmann, Michael T.
Ayeni, Olufemi R.
Marx, Robert G.
Koh, Jason L.
Nakamura, Norimasa
Other Authors
International Society of Arthroscopy Knee Surgery and Orthopaedic Sports Medicine
European Society of Sports Traumatology Knee Surgery and Arthroscopy
Responsibility
Volker Musahl, Jón Karlsson, Michael T. Hirschmann, Olufemi R. Ayeni, Robert G. Marx, Jason L. Koh, Norimasa Nakamura, editors
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
2019
Physical Description
1 online resource (xiv, 584 p.) : 121 illus., 93 illus. in color
ISBN
9783662582541
9783662582534 (Print ed.)
9783662582558 (Print ed.)
Subjects (MeSH)
Orthopedics
Research Design
Specialty
Orthopedics
Research
Abstract
This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS.
Contents
Part I. Evidence Based Medicine in Orthopaedics -- Part II. How to Get Started with Clinical Research? -- Part III. Basics in Statistics: Statistics Made Simple! -- Part IV. Basic Toolbox for the Young Clinical Researcher -- Part V. How to Perform a Clinical Study: A Case Based Approach -- Part VI. How to Perform a Review Article? -- Part VII. How to Perform a Systematic Review or Meta-analysis? -- Part VIII. How to Perform an Economic Health Care Study? -- Part IX. Multi-Center Study: How to Pull It Off? -- Part X. Helpful Further Information
Format
e-Book
Location
Online
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The Biopsychosocial Model of Health and Disease : New Philosophical and Scientific Developments

https://libcat.nshealth.ca/en/permalink/provcat43928
Derek Bolton, Grant Gillett. --Cham: Palgrave Macmillan , c2019.
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Access
Open access
Location
Online
‘This is an incredibly audacious book. Derek Bolton and Grant Gillett brilliantly succeed in providing the big picture that was lacking in the defense of the biopsychosocial model promoted by Engel 40 years ago.’ - Steeves Demazeux, Assistant Professor in philosophy, Bordeaux-Montaigne University, France This open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 ye…
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Author
Bolton, Derek
Other Authors
Gillett, Grant
Responsibility
Derek Bolton, Grant Gillett
Place of Publication
Cham
Publisher
Palgrave Macmillan
Date of Publication
c2019
Physical Description
1 online resource (xiii, 149 p.)
ISBN
9783030118990
9783030118983 (Print ed.)
9783030119003 (Print ed.)
Subjects (MeSH)
Holistic Health
Philosophy, Medical
Social Medicine
Specialty
Public Health
Social Sciences
Abstract
‘This is an incredibly audacious book. Derek Bolton and Grant Gillett brilliantly succeed in providing the big picture that was lacking in the defense of the biopsychosocial model promoted by Engel 40 years ago.’ - Steeves Demazeux, Assistant Professor in philosophy, Bordeaux-Montaigne University, France This open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social. Derek Bolton is Professor of Philosophy and Psychopathology at the Institute of Psychiatry, Psychology and Neuroscience at King’s College London, UK. He was awarded a double first in Moral Sciences and a PhD in Philosophy at the University of Cambridge. His subsequent professional career was in clinical psychology and he has published extensively in philosophy of psychiatry as well as basic and clinical health science. Grant Gillett is Professor of Bioethics at the University of Otago, New Zealand. His professional career was in Neurosurgery, punctuated by a D. Phil. at Oxford University in philosophy of mind and meta-ethics. He has published extensively in neuroethics, philosophy of mind and language, philosophy of medicine (particularly psychiatry), and the philosophy of medical and social sciences.
Contents
1. The Biopsychosocial Model 40 Years On -- 1.1 Doing Well—But with Underlying Problems -- 1.2 Locating the Content of the Biopsychosocial Model -- 1.3 The General Model: Biopsychosocial Ontology and Interactions -- 2. Biology Involves Regulatory Control of Physical–Chemical Energetic Processes -- 2.1 The New Biology/Biomedicine -- 2.2 The Limitations of Physicalism -- 2.3 Current Biomedicine Is Conducive to the Biopsychosocial Model -- 3. Psychology Regulates Activity in the Social World -- 3.1 The Psychological as Embodied Agency -- 3.2 Biopsychosocial Conditions of Agency -- 3.3 The Socio-Political: Who Gets to Control What? -- 3.4 General Theory of Biopsychosocial Systems -- 4. Biopsychosocial Conditions of Health and Disease -- 4.1 Conditions of Biopsychosocial Life -- 4.2 Biopsychosocial Conceptualisation of Health Conditions -- 4.3 Locating Causes in Biopsychosocial Systems -- 4.4 Compare and Contrast Physical and Mental Health Conditions -- 4.5 Locating the Biopsychosocial Model.
Access
Open access
Format
e-Book
Location
Online
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Bio-Psycho-Social Obstetrics and Gynecology : A Competency-Oriented Approach

https://libcat.nshealth.ca/en/permalink/provcat41367
K Marieke Paarlberg, Harry B.M. van de Wiel, editors. --Cham: Springer , 2017.
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Location
Online
This book will assist the reader by providing individually tailored, high-quality bio-psycho-social care to patients with a wide range of problems within the fields of obstetrics, gynecology, fertility, oncology, and sexology. Each chapter addresses a particular theme, issue, or situation in a problem-oriented and case-based manner that emphasizes the differences between routine and bio-psycho-social care. Relevant facts and figures are presented, advice is provided regarding the medical, psych…
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Other Authors
Paarlberg, K Marieke
van de Wiel, Harry B.M
Responsibility
K Marieke Paarlberg, Harry B.M. van de Wiel, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xv, 544 pages) : 35 illus., 21 illus. in color
ISBN
9783319404042
9783319404028 (print ed.)
Subjects (MeSH)
Gynecology - methods
Obstetrics - methods
Physician-Patient Relations
Psychosomatic Medicine - methods
Reproductive Health
Sexual Health
Women's Health
Abstract
This book will assist the reader by providing individually tailored, high-quality bio-psycho-social care to patients with a wide range of problems within the fields of obstetrics, gynecology, fertility, oncology, and sexology. Each chapter addresses a particular theme, issue, or situation in a problem-oriented and case-based manner that emphasizes the differences between routine and bio-psycho-social care. Relevant facts and figures are presented, advice is provided regarding the medical, psychological, and caring process, and contextual aspects are discussed. The book offers practical tips and actions within the bio-psycho-social approach, and highlights important do's and don'ts. To avoid a strict somatic thinking pattern, the importance of communication, multidisciplinary collaboration, and creation of a working alliance with the patient is emphasized. The book follows a consistent format, designed to meet the needs of challenged clinicians.
Contents
Part I: Obstetrics, Gynecology, Fertility and Sexology -- 1. A Woman Afraid to Deliver: How to Manage Childbirth Anxiety -- 2. A Woman Afraid of Becoming Pregnant Again: Posttraumatic Stress Disorder Following Childbirth -- 3. A Woman Who Cannot Enjoy Her Pregnancy: Depression in Pregnancy and Puerperium -- 4. New Mothers with Disturbing Thoughts: Treatment of Obsessive-Compulsive Disorder and of Psychosis in Postpartum - 5. A Woman with a Positive Prenatal Test on Trisomy 21: Counseling in Prenatal Diagnosis -- 6. Parents Who Lost Their Baby: Guiding the Mourning Process in Stillbirths and Pregnancy Terminations -- 7. A Pregnant Woman Who Could Not Stop Drinking: Management of Alcohol Abuse in Pregnancy -- 8. A Young Woman Asking for Labia Reduction Surgery: A Plea for “Vulvar Literacy” -- 9. A Woman Struggling for Control: How to Manage Severe Eating Disorders -- 10. A Woman with Inexplicable Mood Swings: Patient Management of Premenstrual Syndrome -- 11. A Woman Who Suffers Always and Forever: Management of Chronic Pelvic Pain -- 12. A Woman Who Has Been Cut: Female Genital Mutilation from a Global Perspective -- 13. A Woman with Stress Incontinence: Urogenital Complaints and Psychosexual Consequences -- 14. A Couple Who Cannot Conceive: Coping with Infertility -- 15. A Young Woman Facing Cancer Treatment: Shared Decision-Making in Fertility Preservation -- 16. A Couple Who Considers Artificial Reproductive Techniques: Psychosocially Informed Care in Reproductive Medicine -- 17. A Woman Who Never Could Have Coitus: Treatment of Lifelong Vaginismus -- 18. A Woman with Coital Pain: New Perspectives on Provoked Vestibulodynia -- 19. A Woman with Changing Vulvar Anatomy: Sexuality in Women with Lichen Sclerosus -- 20. A Woman Complaining of Lack of Sexual Desire: Sexological Counseling -- Part II: Fundamental Introduction to the Concepts of Clinical Roles, the Meta-competences, and POG Competency Profiles -- 21. A Theoretical and Empirical Study of the Core of the Psychosomatic Approach to Obstetrics and Gynecology: Meta-Competences, Clinical Roles, and POG Competency Profiles -- Part III: Clinical Roles and Meta-competences: The Building Blocks of Psychosomatic Obstetrics and Gynecology -- 22. Introduction -- 23. History: A Historical Perspective on Patient Education in Clinical Practice and in Medical Education -- 24. Scholar: A Scholar Who Cannot See the Woods for the Trees: The Biopsychosocial Model as the Scientific Basis for the Psychosomatic Approach -- 25. Health Advocate: An Obstetrician in Doubt—Coping with Ethical Dilemmas and Moral Decisions -- 26. Communicator: The Gynecologist Who Could Not Convince His Patients -- 27. Collaborator: A Midwife Who Had a Conflict with an Obstetrician—How to Transform “Contact Tics” into “Co Tactics” -- 28. Professional: A Sexologist Who Overstepped the Mark—How to Handle the Therapeutic Relationship in Psychosocial Care -- 29. Leader: A Proof of Leadership, Dealing with and Learning from Work-Related Psychotrauma -- 30. Medical Expert: The Resident Who Passed the Ultimate Test—The Integration of Roles During the Gynecological Examination.
Format
e-Book
Publication Type
Case Reports
Location
Online
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Bipolar Disorder : An Evidence-Based Guide to Manic Depression

https://libcat.nshealth.ca/en/permalink/provcat39398
Kostas N. Fountoulakis. --Berlin, Heidelberg: Springer , c2015.
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Location
Online
This book examines in detail the diagnostic approach to manic depressive (bipolar) illness, with special reference to the borderline zones with unipolar depression and schizoaffective disorder. Among other diagnostic issues considered are mixed episodes (often misdiagnosed by psychiatrists), rapid cycling, and the confusion with personality disorders. Within the context of diagnosis and understanding of the dynamics of bipolar disorder, temperament, character, and personality are all extensivel…
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Author
Fountoulakis, Kostas N
Responsibility
Kostas N. Fountoulakis
Place of Publication
Berlin, Heidelberg
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xx, 721 p. : 44 illus., 20 illus. in color)
ISBN
9783642372162
9783642372155 (print ed.)
Subjects (MeSH)
Bipolar Disorder
Evidence-Based Medicine
Abstract
This book examines in detail the diagnostic approach to manic depressive (bipolar) illness, with special reference to the borderline zones with unipolar depression and schizoaffective disorder. Among other diagnostic issues considered are mixed episodes (often misdiagnosed by psychiatrists), rapid cycling, and the confusion with personality disorders. Within the context of diagnosis and understanding of the dynamics of bipolar disorder, temperament, character, and personality are all extensively discussed. Neurocognitive deficit and disability are covered, as are elements of evolutionary biology and behavior. With regard to treatment, the major focus is on evidence-based therapy, with reference to the results of randomized controlled trials and meta-analyses; in addition, contemporary guidelines and future trends are examined. Careful consideration is also given to the psychosocial treatment approach and issues relating to societal and economic costs and burdens.
Contents
1 Historical Perspective -- 2 Clinical Description -- 3 Long-Term Course -- 4 Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data -- 5 The Role of Temperament -- 6 The Bipolar Spectrum -- 7 Schizoaffective Disorder -- 8 Personality Disorders (Narcissistic, Antisocial, Borderline) -- 9 Alcohol and Substance Use in BD Patients -- 10 Comorbidity -- 11 Classification and Epidemiology -- 12 Disability and Overall Burden Related with Bipolar Disorder -- 13 Aetiopathogenesis of Bipolar Disorder -- 14 Psychometric and Neuropsychological Assessment -- 15 Staging of Bipolar Disorder -- 16 Biological Therapies -- 17 Psychosocial Treatment and Interventions -- 18 Treatment Guidelines -- 20 Creativity and the Position of Bipolar Disorder in Popular Culture.
Format
e-Book
Location
Online
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Breast Cancer : Innovations in Research and Management

https://libcat.nshealth.ca/en/permalink/provcat41607
Umberto Veronesi, Aron Goldhirsch, editors-in-chief ; Paolo Veronesi, Oreste Davide Gentilini, Maria Cristina Leonardi, editors. --Cham: Springer , 2017.
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Location
Online
This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art …
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Other Authors
Veronesi, Umberto
Goldhirsch, Aron
Veronesi, Paolo
Gentilini, Oreste Davide
Leonardi, Maria Cristina
Responsibility
Umberto Veronesi, Aron Goldhirsch, editors-in-chief ; Paolo Veronesi, Oreste Davide Gentilini, Maria Cristina Leonardi, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (xiv, 928 pages) : 296 illus., 236 illus. in color
ISBN
9783319488486
9783319488462 (print ed.)
Subjects (MeSH)
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Abstract
This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.
Contents
Part I: An Integrated view of Breast Cancer Biology -- Fundamental pathways in breast cancer 1: signaling from the membrane -- Fundamental pathways in breast cancer 2: maintenance of genomic stability -- Fundamental pathways in breast cancer 3: estrogen biology -- Fundamental pathways in breast cancer 4: maintenance of epigenomic stability and the role of stem cells -- Breast cancer microenvironment and the metastatic process -- Mouse models of breast cancer -- Human mammary tumor virus proteins in human breast cancer cells -- Part II: Epidemiology, Genetics and Prevention -- Epidemiology, life style and environment -- Genetic predisposition -- Chemoprevention -- Surgical prevention -- Part III Pathology: Standard and Molecular Diagnostics -- Premalignant lesions -- Prognostic and predictive role of genetic signatures -- Adding molecular information to immunohistochemistry -- Special types of breast cancer and nonepithelial tumors -- Pathology after neoadjuvant treatments -- Breast cancer genomics -- Pathology report 2015 -- Part IV: Imaging -- Radiological screening of breast cancer. Evolution -- Innovation of radiological means for breast cancer -- Nuclear medicine in the clinical management (ROLL, SNB and PET) -- One-step systemic staging for patients with breast cancer -- Imaging after breast surgery -- Integrated breast biopsy for best radiological diagnosis of breast cancer -- Part V: Oncological Surgery -- Conservative surgery -- Conservative mastectomies -- Surgical treatment of reappearance of breast cancer -- Management of the axilla -- Management of intraepithelial disease -- Surgery after neoadjuvant therapies -- Surgery of primary tumor in stage IV breast cancers -- Local therapy for breast cancer in malignant lymphoma survivors -- Surgery of metastases -- Part VI: Plastic and Reconstructive Surgery -- Oncoplastic surgery -- Delayed breast reconstruction -- Immediate breast reconstruction direct-to-implant -- Breast reconstruction with tissue expanders and definitive implant replacement -- Breast reconstruction with pedicled flaps -- Breast reconstruction with free flaps -- Contralateral breast management -- Fat grafting in breast reconstruction -- Breast reconstruction with biological and nonbiological meshes -- How to manage complications in breast reconstruction -- Part VII: Medical Oncology -- Adjuvant systemic therapies by subtypes: guidelines -- Primary systemic therapies: guidelines -- Treatment of advanced disease: guidelines -- Endocrine therapies in the adjuvant and advanced disease settings -- Chemotherapy regimens in the adjuvant and advanced disease settings -- Anti-HER2 therapies in the adjuvant and advanced disease settings -- Systemic therapy with bisphosphonates and anti-RANK-L agents -- Systemic treatment for specific medical situations -- Part VIII: Radiotherapy -- Conceptual basis and principles of radiation oncology -- Whole breast radiation following breast-conserving surgery in invasive cancer -- Whole breast radiation following breast-conserving surgery in noninvasive cancer -- Post-mastectomy radiotherapy -- Integration of radiotherapy with systemic therapies -- Partial breast irradiation -- Intraoperative radiotherapy ELIOT -- Radiotherapy for metastatic lesions -- Part IX: Special Conditions Requiring Multidisciplinary Approaches -- Emergencies in breast cancer -- Breast cancer during pregnancy -- Fertility issues in patients with newly diagnosed breast cancer -- Sexual functions and breast cancer -- Male breast cancer -- Inflammatory breast cancer -- Treatment of CNS involvement -- Treatment of skeletal disease -- Follow-up of patients with breast cancer -- Part X: Investigating New Drugs and Immunological Agents in Breast Cancer -- Targeting immune-checkpoint -- Targeting PIK3CA/AKT/mTOR -- Targeting genome instability and DNA repair -- Targeting CDK4/6 pathway -- Targeting FGFR pathway -- Integrating next generation sequencing data in trial design -- Part XI: Investigational and Miscellaneous Approaches -- Lifestyle and breast cancer -- Psychological support -- HIFU and radiofrequency as alternatives to surgery -- Hyperthermia with RT and with systemic therapies -- Electro-chemotherapy -- Circulating miRNA in early diagnosis -- Relevance of stem cells -- Part XII Biostatistics and Bioinformatics -- Subgroup analyses and information from clinical trials on breast cancer -- The methodology of meta analyses and its potential contribution to patient care -- Modern biostatistics for accelerated data acquisition for new drugs -- Bioinformatics for clinical use in breast cancer -- Efficacy endpoints in breast cancer studies.
Format
e-Book
Location
Online
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Breast Disease : Management and Therapies, Volume 2

https://libcat.nshealth.ca/en/permalink/provcat44428
Adnan Aydiner, Abdullah Igci, Atilla Soran, editors. (Second edition) --Cham: Springer , c2019.
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Location
Online
This second updated volume on breast cancer provides a comprehensive overview of its clinical management and current therapies. Updated to reflect the changes in breast cancer staging, the progress in immunotherapy approaches, as well as the latest guidelines for therapies, this book brings readers up to speed with the latest therapeutic regimens in breast cancer and provides an in-depth account of current and new therapeutic approaches. The most important phase III trials, high quality meta-an…
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Other Authors
Aydiner, Adnan
Igci, Abdullah
Soran, Atilla
Responsibility
Adnan Aydiner, Abdullah Igci, Atilla Soran, editors
Edition
Second edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2019
Physical Description
1 online resource (xix, 824 p.) : 161 illus., 136 illus. in color
ISBN
9783030167929
9783030167912 (Print ed.)
9783030167936 (Print ed.)
9783030167943 (Print ed.)
Subjects (MeSH)
Breast Neoplasms - therapy
Specialty
Gynecology
Medical Oncology
Abstract
This second updated volume on breast cancer provides a comprehensive overview of its clinical management and current therapies. Updated to reflect the changes in breast cancer staging, the progress in immunotherapy approaches, as well as the latest guidelines for therapies, this book brings readers up to speed with the latest therapeutic regimens in breast cancer and provides an in-depth account of current and new therapeutic approaches. The most important phase III trials, high quality meta-analysis, consensus reports and guidelines are extensively discussed in this new edition and provide the reader with the most up-to-date information. Divided in themed parts, the book examines invasive breast cancer, pre-operative systemic therapy surgical management and recurrence among others, thus providing an in-depth account of breast cancer at the clinical stage. Among the themed parts are a section dedicated to special therapeutic problems, such as breast cancer in older women, Paget’s disease and phyllodes tumors and a section on supportive and follow-up care. By adopting a multidisciplinary approach to breast cancer, this book is a must-have for breast cancer practitioners. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into clinical practice across different settings. Covering both theoretical and practical aspects of breast cancer, this is a highly informative and carefully presented book which will appeal to an international audience of medical, radiation and surgical oncologists.
Contents
Part I: Invasive Breast Cancer- 1. Biopsy Techniques in Non- palpable or Palpable Breast Lesions -- 2. Evaluations of Patients for Metastases Prior to Primary Therapy -- 3. Staging of Breast Cancer -- 4. Surgical Treatment of Early-Stage Breast Cancer -- 5. Evaluations of Axillary Nodes -- 6. Breast Reconstruction -- 7. Adjuvant Systemic Therapy: Endocrine Therapy -- 8. Adjuvant Systemic Chemotherapy for HER2-Negative Disease -- 9. Adjuvant Therapy for HER2-Positive Early Breast Cancer -- 10. Post-mastectomy Adjuvant Radiotherapy (PMRT) -- 11. Adjuvant Radiation Therapy After Preoperative Chemotherapy -- 12. Breast-Conserving Therapy: Hypo fractionated and Conventional Whole-Breast Irradiation and Accelerated Partial-Breast Irradiation -- Part II: Preoperative Systemic Therapy -- 13 Preoperative Therapies for Operable Breast Cancer -- 14 Neoadjuvant Hormonal Therapies in Breast Cancer -- 15 Systemic Therapies for Locally Advanced Breast Cancer -- 16 Systemic Therapies for Inflammatory Breast Cancer -- Part III: Surgical Management of Patient with Preoperative Systemic Therapy -- 17 Surgical Management of Operable Breast Cancer After Neoadjuvant Systemic Therapy -- 18 Surgical Management of Locally Advanced Breast Cancer -- 19 Surgical Management of Inflammatory Breast Cancer -- Part IV: Special Therapeutic Problems- 20 Occult Primary Breast Cancer with Axillary Metastases -- 21 Breast Cancer in Older Women -- 22 Breast Cancer in Young Women (Premenopausal Breast Cancer) -- 23 Male Breast Cancer -- 24 Breast Cancer in Pregnancy -- 25 Paget’s disease of the Breast -- 26 Phyllodes Tumors of the Breast -- 27 Nonepithelial Malignancies of the Breast -- Part V: Evaluation After Primary Therapy and Management of Recurrent Breast Cancer -- 28 Surveillance of Patients Following Primary Therapy -- 29 Surgeries for the Primary Tumor in Patients with De Novo Stage IV Breast Cancer -- 30 Local-Regional Recurrences After Breast-Conservation Treatment or Mastectomy -- 31 Treatment of Metastatic Breast Cancer: Endocrine Therapy -- 32 Treatment of Metastatic Breast Cancer: Chemotherapy -- 33 Treatment of HER2- Overexpressing Metastatic Breast Cancer -- 34 End-of-Life Considerations in Patients with Breast Cancer -- Part VI: New Breast Cancer Therapeutic Approaches -- 35 Angiogenesis Inhibition in Breast Cancer -- 36 Tyrosine Kinase Inhibitors -- 37 Immunotherapy -- Part VII: Site-Specific Therapy of Metastatic Breast Cancer -- 38 Neurological Metastases -- 39 Ocular Metastases. Nergiz Dagoglu and Anand Mahadevan -- 40 Management of Malignant Pleural Effusions in Breast Cancer -- 41 Management of Discrete Pulmonary Nodules -- 42 Management of Isolated Liver Metastasis -- 43 Bone-Directed Therapy and Breast Cancer: Bisphosphonates, Monoclonal Antibodies, and Radionuclides -- 44 The Local Management of Bone Metastases -- Part VIII: Review of the Breast Cancer Management -- 45 A Review of Local and Systemic Therapy in Breast Cancer -- 46 Decision Pathways in Breast Cancer Management -- Part IX: Supportive Care in Breast Cancer -- 47 Nursing Care and Management -- 48 Psychosocial Adaptation During and After Breast Cancer -- 49 Breast Cancer-Related Lymphedema (BCRL) -- 50 Reproductive Issues in Breast Cancer -- 51 Onco-cardiology for Breast Cancer.
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e-Book
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Breast MRI for High-risk Screening

https://libcat.nshealth.ca/en/permalink/provcat46097
Francesco Sardanelli, Franca Podo, editors. --Cham: Springer , c2020.
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This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomi…
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Other Authors
Sardanelli, Francesco
Podo, Franca
Responsibility
Francesco Sardanelli, Franca Podo, editors
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxiii, 376 p.) : 84 illus., 32 illus. in color
ISBN
9783030412074
9783030412067 (Print ed.)
9783030412081 (Print ed.)
9783030412098 (Print ed.)
Subjects (MeSH)
Breast Neoplasms - diagnosis
Diagnostic Screening Programs
Female
Genetic Predisposition to Disease
Magnetic Resonance Imaging - methods
Specialty
Diagnostic Imaging
Gynecology
Abstract
This book offers a comprehensive overview of the use of breast MRI for screening high-risk women, including those with familial-genetic hereditary predisposition and previous chest radiation therapy, typically lymphoma survivors. It discusses the historical background of studies and research that provided the body of evidence in favor of MRI screening of these women. Technical and clinical topics are treated in dedicated chapters, including models for individualized risk estimation, radiogenomics of breast cancer in high-risk women, computer-aided detection/diagnosis and machine learning systems applied to breast MRI, and psycho-oncology issues. Alternatives to breast MRI screening such as pharmaco-prevention and prophylactic mastectomy are also discussed, taking into account the public debate on the “Angelina Jolie” effect. The high breast cancer risk model is proposed as a paradigm for personalized medicine. This book will be of interest to radiologists, surgeons, oncologists and to all professionals devoted to female healthcare.
Contents
1. From NMR to Clinical Breast MRI -- 2. The Mantra about Low Specificity of Breast MRI -- 3. Hereditary Breast Cancer: BRCA and Other Susceptibility Genes -- 4. MRI Protocols for Breast Cancer Screening -- 5. Gadolinium-Based Contrast Agents for Breast MRI and Uncertainties About Brain Gadolinium Retention -- 6. Applying the MRI BI-RADS in a High-Risk Population -- 7. CAD and Machine Learning for Breast MRI -- 8. Radiogenomics and Phenotype Presentation of Breast Cancer with a Special Focus on High-Risk Women -- 9. Primary Studies on Breast MRI Screening of High-Risk Women -- 10. Genetic/Familial High-Risk Screening: MRI Alone? -- 11. Systematic Reviews, Meta-Analyses, and Cost-Effective Analyses on Breast MRI Screening of High-Risk Women -- 12. Radioprotection Issues for Women with Hereditary Predisposition for Breast Cancer -- 13. Impact of MRI Screening on High-Risk Patient Outcome -- 14. The Special Case of Previous Chest Radiation Therapy -- 15. Electronic Data Capture Systems for Breast Cancer Research -- 16. Guidelines and Recommendations on High-Risk Breast Cancer Screening All Over the World: Agreements and Differences -- 17. A Soft Option for Primary Prevention: Drugs and Agents -- 18. Surgical Options for Primary Prevention: Prophylactic Mastectomy and Oophorectomy -- 19. Psychological Aspects of High Risk of Breast Cancer -- 20. Calculating, Using and Improving Individual Breast Cancer Risk Estimates -- 21. MRI for Screening Women with a Personal History of Breast Cancer -- 22. Breast MRI Screening for the Intermediate Risk: An Open Issue -- 23. Hypotheses for the Future.
Format
e-Book
Location
Online
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Cannabis in Medicine : An Evidence-Based Approach

https://libcat.nshealth.ca/en/permalink/provcat45327
Kenneth Finn, editor. --Cham: Springer , c2020.
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Legalization of marijuana is becoming increasingly prominent in the United States and around the world. While there is some discussion of the relationship between marijuana and overall health, a comprehensive resource that outlines the medical literature for several organ systems, as well as non-medical societal effects, has yet to be seen. While all physicians strive to practice evidence-based medicine, many clinicians aren't aware of the facts surrounding cannabis and are guided by public opi…
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Other Authors
Finn, Kenneth
Responsibility
Kenneth Finn, editor
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxxi, 554 p.) : 39 illus., 32 illus. in color
ISBN
9783030459680
9783030459673 (Print ed.)
9783030459697 (Print ed.)
Subjects (MeSH)
Cannabinoids - pharmacology
Cannabinoids - therapeutic use
Medical Marijuana - therapeutic use
Specialty
Pharmacology
Abstract
Legalization of marijuana is becoming increasingly prominent in the United States and around the world. While there is some discussion of the relationship between marijuana and overall health, a comprehensive resource that outlines the medical literature for several organ systems, as well as non-medical societal effects, has yet to be seen. While all physicians strive to practice evidence-based medicine, many clinicians aren't aware of the facts surrounding cannabis and are guided by public opinion. This first of its kind book is a comprehensive compilation of multiple facets of cannabis recommendation, use and effects from a variety of different perspectives. Comprised of chapters dedicated to separate fields of medicine, this evidence-based guide outlines the current data, or lack thereof, as well as the need for further study. The book begins with a general overview of the neurobiology and pharmacology of THC and hemp. It then delves into various medical concerns that plague specific disciplines of medicine such as psychiatry, cardiology, gastrointestinal and neurology, among others. The end of the book focuses on non-medical concerns such as public health and safety, driving impairment and legal implications. Comprised of case studies and meta-analyses, Cannabis in Medicine: An Evidence-Based Approach provides clinicians with with a concise, evidence-based guide to various health concerns related to the use of marijuana. By addressing non-medical concerns, this book is also a useful resource for professionals working in the public health and legal fields.
Contents
Forward: Losing Ground: The Rise of Cannabis Culture -- Part I. Basic Science -- 1. The Properties and Use of Cannabis Sativa Herb and Extracts -- 2. Cannabinoid and Marijuana Neurobiology -- 3. The Pharmacodynamics, Pharmacokinetics, and Potential Drug Interactions of Cannabinoids -- Part II. Clinical Evidence -- 4. Cannabis and Neuropsychiatric Effects -- 5. Cannabis and the Impact on the Pediatric and Adolescent Population -- 6. Acute Emergency Department Presentations Related to Cannabis -- 7. Evidence of Cannabinoids in Pain -- 8. Cannabis in Pulmonary Medicine -- 9. Clinical Cardiovascular Effects of Cannabis Use -- 10. Cannabinoids in Neurologic Conditions -- 11. Ocular Conditions and the Endocannabinoid System -- 12. Cannabis in Oncology and Symptom Management -- 13. Cannabis in Palliative Medicine -- 14. Cannabis in Older Persons -- 15. Cannabinoids in Dermatology -- 16. Fetal and Neonatal Marijuana Exposure -- 17. Cannabinoids in Gastrointestinal Disorders -- 18. Looking at Marijuana Through the Lens of Public Health -- 19. Cannabis-Impaired Driving: Evidence and the Role of Toxicology Testing -- 20. The Legal Aspects of Marijuana as Medicine -- Epilogue: Epilogue: The Medical Cannabis Landscape.
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e-Book
Location
Online
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Cardiovascular Safety in Drug Development and Therapeutic Use : New Methodologies and Evolving Regulatory Landscapes

https://libcat.nshealth.ca/en/permalink/provcat41365
J. Rick Turner, Dilip R. Karnad, Snehal Kothari. --Cham: Adis , 2017.
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With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant. Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny probl…
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Author
Turner, J. Rick
Other Authors
Karnad, Dilip R.
Kothari, Snehal
Responsibility
J. Rick Turner, Dilip R. Karnad, Snehal Kothari
Place of Publication
Cham
Publisher
Adis
Date of Publication
2017
Physical Description
1 online resource (xxvi, 342 pages) : 2 illus. in color
ISBN
9783319403472
9783319403458 (print ed.)
Subjects (MeSH)
Cardiotoxicity - prevention & control
Cardiovascular Diseases - etiology
Drug Design
Drug Evaluation, Preclinical
Abstract
With the advent of multiple new therapeutic agents for a variety of important diseases has come an increasing realization that many of these drugs can have adverse effects on the heart and vascular system. As this book so elegantly details the mechanisms by which harm occurs are highly complex, many times predictable, but always clinically relevant. Notable experts in the field of cardiovascular medicine, such as Drs. Turner, Karnad, and Kothari, have turned their attention to this thorny problem, and begun to dissect the diverse mechanisms by which cardiac harm can occur with a variety of non-cardiac drugs. This is no easy task, given the complexity of the diseases we treat, and the wide spectrum of new therapies we seek to apply. However, it is an issue with which all health care providers must become familiar in order to prescribe appropriate therapy while safeguarding patients against avoidable and life-threatening cardiac adverse effects. This compendium represents the state-of-the-art in the evolving field of cardiac safety and is vital reading for those interested in developing new chemical entities, as well as those who prescribe them and monitor patients for their hazard. As such, I recommend this book as essential reading for students, scientists, and health care providers at all levels of training. Peter R. Kowey, MD, FACC, FAHA, FHRS Lankenau Institute for Medical Research & Thomas Jefferson University.
Contents
Part: I Introduction -- 1. The Central Role of Cardiovascular Safety in Drug Development and Therapeutic Use -- Part II: A Primer of Biological and Physiological Considerations -- 2. Drug Structures and the Biological Basis of Drug Responses -- 3. Cardiovascular Structure, Function, and Pathophysiology -- Part III: A Primer of Statistical Considerations -- 4. Analyzing and Reporting Efficacy Data -- 5. Analyzing and Reporting Safety Data -- 6. Meta-analysis, Group Sequential Study Designs, Centralized Endpoint Adjudication, and Composite Endpoints -- Part IV: Proarrhythmic Cardiac Safety -- 7. The Proarrhythmic Cardiac Safety Regulatory Landscape Circa 2005–2015: Drug-Induced hERG Channel Block and the Thorough QT/QTc Study -- 8. QTc Exposure–Response Modeling as a Primary Methodology for Proarrhythmic Cardiac Safety Assessments -- 9. The Comprehensive In Vitro Proarrhythmia Assay Initiative -- Part V: Additional Domains of Cardiovascular Safety -- 10. Oncology Drug Therapy: Cardiotoxicity and the Discipline of Cardio-oncology -- 11. Blood Pressure Responses to Noncardiovascular Drugs in Development and Therapeutic Use -- 12. The Genesis of Cardiovascular Safety Regulatory Landscapes for New Antidiabetic Drugs for Type 2 Diabetes -- 13. Satisfying the Regulatory Requirements for New Antidiabetic Drugs for Type 2 Diabetes Most -- Part VI: Additional Considerations in General Drug Safety and Therapeutic Use -- 14. Postmarketing Cardiovascular Safety Considerations -- 15. A Safety Perspective on Additional Aspects of Drug Development and Therapeutic Use -- Afterword.
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e-Book
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Caring for Latinxs with Dementia in a Globalized World : Behavioral and Psychosocial Treatments

https://libcat.nshealth.ca/en/permalink/provcat45389
Hector Y. Adames, Yvette N. Tazeau, editors. --New York, NY: Springer , c2020.
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This volume provides a broad and critical presentation of the behavioral and psychosocial treatments of Latinxs with dementia in the United States (U.S.) and across a representative sample of Spanish-speaking countries in the world. The compendium of chapters, written by researchers, practitioners, and policy analysts from multiple disciplines provides a deep exploration of the current state of dementia care for Latinxs in the U.S. and around the globe. The volume is designed to increase and st…
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Other Authors
Adames, Hector Y.
Tazeau, Yvette N.
Responsibility
Hector Y. Adames, Yvette N. Tazeau, editors
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2020
Physical Description
1 online resource (xxvi, 415 p.) : 8 illus.)
ISBN
9781071601327
9781071601303 (Print ed.)
9781071601310 (Print ed.)
9781071606940 (Print ed.)
Subjects (MeSH)
Dementia - diagnosis
Dementia - epidemiology
Dementia - therapy
Mental Health Services
Other Subjects
Latin America
Specialty
Mental Health Services
Abstract
This volume provides a broad and critical presentation of the behavioral and psychosocial treatments of Latinxs with dementia in the United States (U.S.) and across a representative sample of Spanish-speaking countries in the world. The compendium of chapters, written by researchers, practitioners, and policy analysts from multiple disciplines provides a deep exploration of the current state of dementia care for Latinxs in the U.S. and around the globe. The volume is designed to increase and strengthen the collective scientific and sociocultural understanding of the epidemiological and biopsychosocial factors, as well as the overlapping systemic challenges that impact diagnosis and symptom management of Latinxs with dementia. The authors introduce policy options to reduce risk factors for dementia and present culturally-responsive interventions that meet the needs of Latinx patients and their caregivers. Caring for Latinxs with Dementia in a Globalized World: Behavioral and Psychosocial Treatments is a resource that accentuates and contextualizes the heterogeneity in nationality, immigration, race, sexual orientation, gender, and political realities. It is a key reference for a wide range of fields inclusive of demography, geriatrics, gerontology, medicine, mental health, neurology, neuropsychology, nursing, occupational therapy, pharmacology, psychiatry, psychology, rehabilitation, social work, sociology, and statistics all of which, collectively, bear on the problem and the solutions for better care for Latinxs affected by dementia.
Contents
Part I. Characterizing the Context: Latinxs and Dementia -- 1. Demographics and the Epidemiological Risk Factors for Dementia in Hispanic/Latino Populations -- 2. Contextual, Cultural, and Socio-political Issues in Caring for Latinxs with Dementia: When the Mind Forgets and the Heart Remembers -- 3. Meta-Analysis of Dementia Rates in Central America, South America, and the Caribbean -- Part II. Evaluation, Assessment, and Diagnosis -- 4. Treating Medical Comorbidities Associated with Dementia among Latinos -- 5. Functional Assessment in Latinos with Dementia: A Review of Tools and Cultural Considerations -- 6. Latinos with Dementia and Depression: Contemporary Issues and Assessment Challenges -- 7. Neurological, Psychiatric, and Affective Aspects of Dementia in Latinxs -- Part III. Supportive Interventions and Services -- 8. Latino Families Living with Dementia: Behavioral Issues and Placement Considerations -- 9. Educational, Diagnostic, and Supportive Psychosocial Interventions for Latinos with Dementia -- 10. Cognitive Rehabilitation for Maintenance of Function in Latinos with Dementia -- 11. Behavioral Symptoms of Dementia in Latinos: Pharmacological, Non-pharmacological, and Ethnocultural Healthcare Interventions -- 12. Intersectionality as a Practice of Dementia Care for Sexual and Gender Minoritized Latinxs -- 13. Stress and Coping: Conceptual Models for Understanding Dementia among Latinos -- 14. Grief, Loss, and Depression in Latino Caregivers and Families affected by Dementia -- Part IV. International Perspectives: The Americas and Beyond -- 15. Behavioral and Psychosocial Treatments of Dementia in Mexico -- 16. Dementia Care in Guatemala, Central America -- 17. Behavioral and Psychosocial Treatments of Dementia in the Caribbean: Cuba, Dominican Republic, and Puerto Rico -- 18. Dementia Treatment and Health Disparities among Puerto Ricans: The Impact of its Cultural and Political Histories -- 19. Dementia Diagnosis, Treatment, and Care in Colombia, South America -- 20. Behavioral and Psychosocial Treatments of Dementia in Spain -- Part V. Social/Public Policy and Community Perspectives -- 21. Community Partnerships and the Care of Latinos with Dementia: A Call for Action -- 22. Latinos and Dementia: Prescriptions for Policy and Programs that Empower Older Latinos and their Families.
Format
e-Book
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Online
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Chest Sonography

https://libcat.nshealth.ca/en/permalink/provcat41508
Gebhard Mathis, editor. (Fourth edition) --Cham: Springer , 2017.
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This book, widely regarded as the standard work in the field, presents the state of the art in chest sonography with the aid of a wealth of excellent illustrations. It provides the reader with concise, easy-to-assimilate information on all aspects of the use of the modality, including indications, investigative techniques, diagnostic decision making, and imaging artifacts and pitfalls. Numerous tips and tricks and potential sources of diagnostic error are highlighted to aid in daily clinical pr…
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Other Authors
Mathis, Gebhard
Responsibility
Gebhard Mathis, editor
Edition
Fourth edition
Place of Publication
Cham
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (vii, 219 pages) : 47 illus., 42 illus. in color
ISBN
9783319440729
9783319440712 (print ed.)
Subjects (MeSH)
Thoracic Cavity - diagnostic imaging
Thoracic Diseases - diagnostic imaging
Thoracic Wall - diagnostic imaging
Ultrasonography - methods
Abstract
This book, widely regarded as the standard work in the field, presents the state of the art in chest sonography with the aid of a wealth of excellent illustrations. It provides the reader with concise, easy-to-assimilate information on all aspects of the use of the modality, including indications, investigative techniques, diagnostic decision making, and imaging artifacts and pitfalls. Numerous tips and tricks and potential sources of diagnostic error are highlighted to aid in daily clinical practice. This fourth edition has been extensively revised to take full account of the latest techniques, study results, and meta-analyses, with inclusion of important additional illustrative material. An entirely new chapter is devoted to interstitial syndrome, and detailed guidance is provided on contrast-enhanced sonography, ultrasound techniques for evaluation of the mediastinum, and the role of chest sonography in emergency medicine. As the value of the technique continues to grow, readers will find Chest Sonography to be a superb up-to-date resource and guide.
Contents
Indications, Technical Equipment and Investigation Procedure -- Ultrasonography of the Chest Wall -- Pleura -- Interstitial Syndrome -- Lung Consolidation -- Mediastinum -- Endobronchial Sonography -- Vascularization -- Image Artifacts and Pitfalls -- Interventional Chest Sonography -- From the Symptom to the Diagnosis -- Emergency Thoracic Ultrasound (Excluding Echocardiography).
Format
e-Book
Location
Online
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Clinical Assessment of the Autonomic Nervous System

https://libcat.nshealth.ca/en/permalink/provcat41917
Satoshi Iwase, Junichiro Hayano, Satoshi Orimo, editors. --Tokyo: Springer , 2017.
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This book describes newly developed methods of assessing the autonomic nervous system. Up-to-date information on microneurographic analysis of human cardiovascular and thermoregulatory function in humans, heart rate variability, and 131I-metaiodobenzylguanidine (MIBG) scintigraphy are provided. Microneurography, which was originally developed as a technique to analyze the afferent muscle spindle, came to be used to analyze sympathetic nerve activity in the mid-1980s. In the twenty-first century…
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Other Authors
Iwase, Satoshi
Hayano, Junichiro
Orimo, Satoshi
Responsibility
Satoshi Iwase, Junichiro Hayano, Satoshi Orimo, editors
Place of Publication
Tokyo
Publisher
Springer
Date of Publication
2017
Physical Description
1 online resource (viii, 317 pages) : 103 illus., 38 illus. in color
ISBN
9784431560128
9784431560104 (print ed.)
Subjects (MeSH)
Cardiac Imaging Techniques - methods
Arrhythmias, Cardiac - diagnosis
Autonomic Nervous System - physiopathology
Heart Rate - physiology
Radionuclide Imaging - methods
Abstract
This book describes newly developed methods of assessing the autonomic nervous system. Up-to-date information on microneurographic analysis of human cardiovascular and thermoregulatory function in humans, heart rate variability, and 131I-metaiodobenzylguanidine (MIBG) scintigraphy are provided. Microneurography, which was originally developed as a technique to analyze the afferent muscle spindle, came to be used to analyze sympathetic nerve activity in the mid-1980s. In the twenty-first century, this technique has become prevalent all over the world especially in investigating the pathophysiology of human cardiovascular function. It is also now used in researching human thermoregulatory function. Heart rate variability is another valuable tool in investigating the current status of human vagal function and in predicting future cardiovascular disease. MIBG is also used to assess cardiac noradrenergic function, especially decreases associated with Parkinson's disease, Lewy body disease, and multisystem atrophy. Overviews of recent advances in these three important assessments are provided by leading experts. Clinical Assessment of the Autonomic Nervous System is a useful resource for neurologists and researchers of clinical neurophysiology.
Contents
PART I: Sympathetic Microneurography -- 1. Introduction to Sympathetic Microneurography -- 2. Muscle Sympathetic Nerve Activity in Neurological Disorders -- 3. Muscle Sympathetic Nerve Activity and Cardiovascular Diseases -- 4. Skin sympathetic nerve activity and thermoregulatory control in humans -- 5. Muscle Sympathetic Nerve Activity and Syncope -- 6. Single Fiber Analysis of Muscle Sympathetic Nerve Activity -- PART II: Heart Rate Variability (HRV) -- 7. Introduction to Heart Rate Variability -- 8. Respiratory Sinus Arrhythmia and Entraining Heartbeats with Cheyne-Stokes Respiration - Cardiopulmonary Works to be Minimal by Synchronizing Heartbeats with Breathing -- 9. Heart RateVariability and Sympathetic Nerve Activity -- 10. Heart Rate Variability and Cardiac Diseases -- 11. Heart-rate Variability and Neurological Disorders -- PART III: Cardiac MIBG Scintigraphy -- 12. An introduction to MIBG cardiac scintigraphy -- 13. Noradrenaline and 123I-meta-iodobenzylguanidine Kinetics in the Sympathetic Nervous System -- 14. Technical Considerations for MIBG Cardiac Scintigraphy -- 15. Findings of 123I-MIBG cardiac scintigraphy : ParkinsonÇÖs disease and related disorders, and others. (RBD, cardiac diseases, DM, etc) -- 16. Findings of MIBG Cardiac Scintigraphy: Dementia with Lewy Bodies and Related Dementia -- 17. Physiological Background of Reduced Cardiac 123I-metaiodobenzylguanidine Uptake -- 18. Pathological background of reduced cardiac MIBG uptake -- 19. Clinical Implication of Reduced Cardiac MIBG Uptake.
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e-Book
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Online
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Clinical decision support : the road ahead

https://libcat.nshealth.ca/en/permalink/provcat27204
Greenes, Robert A. --Burlington, MA: Elsevier/Academic Press , 2007.
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Online
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Author
Greenes, Robert A
Place of Publication
Burlington, MA
Publisher
Elsevier/Academic Press
Date of Publication
2007
Physical Description
581 p.
ISBN
9786610746880
Subjects (MeSH)
Decision Support Systems, Clinical - trends
Electronic Health Records
Medical Informatics Applications
Contents
Cover -- Copyright Page -- Table of Contents -- Contributors -- Preface -- PART I COMPUTER-BASED CLINICAL DECISION SUPPORT: CONCEPTS AND ORIGINS -- Chapter 1 DEFINITION, SCOPE, AND CHALLENGES -- 1.1 INTRODUCTION -- 1.2 DEFINITION OF COMPUTER-BASED CLINICAL DECISION SUPPORT -- 1.3 FEATURES OF CDS -- 1.4 THE TALE OF A RELATIONSHIP -- 1.5 SCOPE AND PLAN OF THIS BOOK -- REFERENCES -- Chapter 2 A BRIEF HISTORY OF CLINICAL DECISION SUPPORT: TECHNICAL, SOCIAL, CULTURAL, ECONOMIC, AND GOVERNMENTAL PERSPECTIVES -- 2.1 PRIMARY RESEARCH METHODOLOGIES THAT HAVE BEEN PURSUED AND EXTENDED -- 2.2 DRIVING FORCES FOR CDS -- 2.3 CONCLUSION -- REFERENCES -- Chapter 3 FEATURES OF COMPUTER-BASED CLINICAL DECISION SUPPORT -- 3.1 CDS AND THE HUMAN -- 3.2 DESIGN AND STRUCTURE OF CDS -- 3.3 OTHER CONSIDERATIONS -- REFERENCES -- PART II CASE STUDIES AND CURRENT STATUS -- Chapter 4 REGENSTRIEF MEDICAL INFORMATICS: EXPERIENCES WITH CLINICAL DECISION SUPPORT SYSTEMS -- 4.1 INTRODUCTION -- 4.2 HISTORY -- 4.3 CONCLUSION -- REFERENCES -- Chapter 5 PATIENTS, DOCTORS, AND INFORMATION TECHNOLOGY: CLINICAL DECISION SUPPORT AT BRIGHAM AND WOMEN'S HOSPITAL AND PARTNERS HEALTHCARE -- 5.1 HISTORY -- 5.2 CLINICAL DECISION SUPPORT AND INPATIENT CPOE AT BWH -- 5.3 DECISION SUPPORT DELIVERED USING THE OUTPATIENT ELECTRONIC HEALTH RECORD -- 5.4 OVERARCHING STUDIES -- 5.5 OVERARCHING LESSONS -- 5.6 FUTURE DIRECTIONS -- REFERENCES -- Chapter 6 CASE STUDIES IN CLINICAL DECISION SUPPORT: LDS HOSPITAL EXPERIENCE -- 6.1 INTRODUCTION -- 6.2 TOOLS FOR INFORMATION MANAGEMENT -- 6.3 TOOLS FOR FOCUSING ATTENTION -- 6.4 TOOLS FOR PATIENT-SPECIFIC CONSULTATION -- 6.5 CONCLUSION -- REFERENCES -- Chapter 7 PENETRATION AND AVAILABILITY OF CLINICAL DECISION SUPPORT IN COMMERCIAL SYSTEMS -- 7.1 INTRODUCTION -- 7.2 CDS PENETRATION AND AVAILABILITY IN COMMERCIAL SYSTEMS -- 7.3 CLINICAL ALERTING IN 2002 -- 7.4 OBSTACLES TO CDS IN 2002 -- 7.5 WHAT CHANGED SINCE EARLY 2002? -- 7.6 HOW FAR ALONG ARE CDS VENDORS IN 2005? -- 7.7 SELF-REPORTED VENDOR DATA AS OF FEBRUARY 2005 -- 7.8 CONCLUSION -- REFERENCES -- VENDOR WEB SITE REFERENCES -- Chapter 8 LESSONS LEARNED -- 8.1 ACADEMIC PROTOTYPES -- 8.2 STANDARDS AND SHARING OF INTEROPERABLE CONTENT AND TOOLS -- 8.3 USERS -- 8.4 OTHER CONSIDERATIONS -- REFERENCES -- PART III GENERATION AND FORMULATION OF KNOWLEDGE -- Chapter 9 HUMAN-INTENSIVE TECHNIQUES -- 9.1 INTRODUCTION -- 9.2 THEORETICAL BASIS FOR KNOWLEDGE ACQUISITION -- 9.3 COGNITIVE TASK ANALYSIS -- 9.4 COMPUTER-BASED KNOWLEDGE ACQUISITION -- 9.5 CONCLUSION -- REFERENCES -- Chapter 10 GENERATION OF KNOWLEDGE FOR CLINICAL DECISION SUPPORT: STATISTICAL AND MACHINE LEARNING TECHNIQUES -- 10.1 INTRODUCTION -- 10.2 LEARNING FROM DATA -- 10.3 OVERVIEW OF LOGISTIC REGRESSION -- 10.4 OVERVIEW OF SOME MACHINE LEARNING MODELS -- 10.5 PREDICTION MODELS IN MEDICINE -- 10.6 CONCLUSION -- REFERENCES -- Chapter 11 EVIDENCE-BASED MEDICINE AND META-ANALYSIS: GETTING MORE OUT OF THE LITERATURE -- 11.1 SYSTEMATIC REVIEWS AND META-ANALYSES -- 11.2 METHODOLOGIES OF SYSTEMATIC REVIEW AND META-ANALYSIS -- 11.3 DEVELOPING A SYSTEMATIC REVIEW PR
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e-Book
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Clinical Research : Case Studies of Successes and Failures

https://libcat.nshealth.ca/en/permalink/provcat39021
John G. Brock-Utne. --New York, NY: Springer , c2015.
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Location
Online
This book provides insights into how to be a productive clinical researcher via real-life case examples of successful clinical research -- and also clinical research gone awry. Through these examples of success and failure, the book develops a blueprint for building a career in clinical research. Future medical practice depends on the quality of the clinical trials to which drugs, devices, and treatment procedures are subjected today. However, clinical trials are not easy to do, and many physic…
Available Online
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Author
Brock-Utne, John G
Responsibility
John G. Brock-Utne
Place of Publication
New York, NY
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (xxiv, 181 p.)
ISBN
9781493925162
9781493925155 (print ed.)
Subjects (MeSH)
Biomedical Research
Abstract
This book provides insights into how to be a productive clinical researcher via real-life case examples of successful clinical research -- and also clinical research gone awry. Through these examples of success and failure, the book develops a blueprint for building a career in clinical research. Future medical practice depends on the quality of the clinical trials to which drugs, devices, and treatment procedures are subjected today. However, clinical trials are not easy to do, and many physicians and health care providers who attempt clinical research struggle in this endeavor, primarily because of lack of instruction. Clinical Research aims to fill the gap between training and research through case studies of a long-time clinical researcher's rich and varied experiences.
Contents
1. A "good" question -- 2. A "bad" question -- 3. Why were 116 patients excluded? -- 4. Sometimes a good question evolves from a bad one -- 5. What went wrong? -- 6. Check your facts -- 7. All is not lost -- 8. An important lesson -- 9. A lucky escape -- 10. A letter or a full paper -- 11. This could be serious. Be prepared -- 12. Not correct procedure -- 13. A lesson well learned -- 14. Taking out a patent. Should you or should you not? -- 15. Taking out a patent.á Watch out -- 16. A laboratory lesson -- 17. Before you start any research -- 18. An offer of employment.á What to look for -- 19. What should you do? -- 20. Who to trust -- 21. Elementary -- 22. Never give up -- 23. How long should a study go on? -- 24. What to do -- 25. To what journal should you send your work? -- 26. A drug sponsored trial -- 27. The difference between research and quality assurance/improvement -- 28. Stopping a clinical study -- 29. Controversy -- 30. The P Value -- 31. How many authors? -- 32. If you injure your patient -- 33. Multicenter trials -- 34. Unprofessional behavior -- 35. Tips on how to get the Institutional Review Board (IRB) submission completed and passed -- 36. How to perform and report the result of a survey -- 37. Validity of the cricoid pressure (Sellick's maneuver -- 38. Another unprofessional behavior -- 39. A data set -- 40. Taking over an ongoing clinical trial -- 41. Should you do a pilot study in this proposed trial? -- 42. An inconclusive result (negative result). What to do -- 43. Retrospective studies. What to watch out for -- 44. Plagiarism -- 45. Pediatric research -- 46. Your paper is rejected. What to do -- 47. You disagree with a conclusion of a published article -- 48. Is this a good study? -- 49. Meta-analysis of randomized controlled trials -- 50. Is the title of a paper or grant important? -- 51. Sampling and subjects -- 52. What not to do if you are a mentor -- 53. Be aware -- 54. A statistical impasse -- 55. A bad outcome -- 56. A case report -- 57. Are case reports becoming extinct -- 58. A clinical pharmacology study -- 59. Watch out -- 60. A new equipment -- 61. Those that ignore the past -- 62. What are the safety data for this formulation? -- 63. This is a test to see what you have learned -- Review of the clinical research process. From the beginning to the end -- The future of clinical research -- Summary of pearls.
Format
e-Book
Publication Type
Case Reports
Location
Online
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A clinician's guide to statistics and epidemiology in mental health : measuring truth and uncertainty

https://libcat.nshealth.ca/en/permalink/provcat27750
S. Nassir Ghaemi. --Cambridge: Cambridge University Press , 2009.
Available Online
View e-Book
Location
Online
Available Online
View e-Book
Author
Ghaemi, S. Nassir
Responsibility
S. Nassir Ghaemi
Place of Publication
Cambridge
Publisher
Cambridge University Press
Date of Publication
2009
Physical Description
151 p.
Series Title
Cambridge medicine
ISBN
9780511581250 (ebook)
9780521709583 (paperback)
Subjects (MeSH)
Mental Disorders - epidemiology
Psychiatry - methods
Statistics as Topic
Contents
Why data never speak for themselves -- Why you cannot believe your eyes : the three C's -- Levels of evidence -- Types of bias -- Randomization -- Regression -- Hypothesis testing : the dreaded p-value and statistical significance -- The use of hypothesis testing statistics in clinical trials -- The better alternative : effect estimation -- What does causation mean? -- A philosophy of statistics -- Evidence-based medicine : defense and criticism -- The alchemy of meta-analysis -- Bayesian statistics : why your opinion counts -- How journal articles get published -- How scientific research impacts practice -- Dollars, data, and drugs -- Bioethics and the clinician/researcher divide.
Format
e-Book
Location
Online
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Cloud-Based Benchmarking of Medical Image Analysis

https://libcat.nshealth.ca/en/permalink/provcat43945
Allan Hanbury, Henning Müller, Georg Langs, editors. --Cham: SpringerOpen , c2017.
Available Online
View e-Book
Access
Open access
Location
Online
This book is open access under a CC BY-NC 2.5 license. ; This book presents the VISCERAL project benchmarks for analysis and retrieval of 3D medical images (CT and MRI) on a large scale, which used an innovative cloud-based evaluation approach where the image data were stored centrally on a cloud infrastructure and participants placed their programs in virtual machines on the cloud. The book presents the points of view of both the organizers of the VISCERAL benchmarks and the participants. The …
Available Online
View e-Book
Other Authors
Hanbury, Allan
Müller, Henning
Langs, Georg
Responsibility
Allan Hanbury, Henning Müller, Georg Langs, editors
Place of Publication
Cham
Publisher
SpringerOpen
Date of Publication
c2017
Physical Description
1 online resource (xviii, 254 p.) : 93 illus., 39 illus. in color
ISBN
9783319496443
9783319496429 (Print ed.)
9783319496436 (Print ed.)
9783319842073 (Print ed.)
Subjects (MeSH)
Diagnostic Imaging - methods
Image Interpretation, Computer-Assisted
Image Processing, Computer-Assisted
Specialty
Diagnostic Imaging
Medical Informatics
Abstract
This book is open access under a CC BY-NC 2.5 license.
This book presents the VISCERAL project benchmarks for analysis and retrieval of 3D medical images (CT and MRI) on a large scale, which used an innovative cloud-based evaluation approach where the image data were stored centrally on a cloud infrastructure and participants placed their programs in virtual machines on the cloud. The book presents the points of view of both the organizers of the VISCERAL benchmarks and the participants. The book is divided into five parts. Part I presents the cloud-based benchmarking and Evaluation-as-a-Service paradigm that the VISCERAL benchmarks used. Part II focuses on the datasets of medical images annotated with ground truth created in VISCERAL that continue to be available for research. It also covers the practical aspects of obtaining permission to use medical data and manually annotating 3D medical images efficiently and effectively. The VISCERAL benchmarks are described in Part III, including a presentation and analysis of metrics used in evaluation of medical image analysis and search. Lastly, Parts IV and V present reports by some of the participants in the VISCERAL benchmarks, with Part IV devoted to the anatomy benchmarks and Part V to the retrieval benchmark. This book has two main audiences: the datasets as well as the segmentation and retrieval results are of most interest to medical imaging researchers, while eScience and computational science experts benefit from the insights into using the Evaluation-as-a-Service paradigm for evaluation and benchmarking on huge amounts of data.
Contents
Part I. Evaluation-as-a-Service -- VISCERAL: Evaluation-as-a-Service for Medical Imaging -- Using the Cloud as a Platform for Evaluation and Data Preparation -- Part II. VISCERAL Datasets -- Ethical and Privacy Aspects of Using Medical Image Data -- Annotating Medical Image Data -- Datasets Created in VISCERAL -- Part III. VISCERAL Benchmarks -- Evaluation Metrics for Medical Organ Segmentation and Lesion Detection -- VISCERAL Anatomy Benchmarks for Organ Segmentation and Landmark Localisation: Tasks and Results -- Retrieval of Medical Cases for Diagnostic Decisions: VISCERAL Retrieval Benchmark -- Part IV. VISCERAL Anatomy Participant Reports -- Automatic Atlas-Free Multi-Organ Segmentation of Contrast-Enhanced CT Scans -- Multi-organ Segmentation Using Coherent Propagating Level Set Method Guided by Hierarchical Shape Priors and Local Phase Information -- Automatic Multi-Organ Segmentation Using Hierarchically-Registered Probabilistic Atlases -- Multi-Atlas Segmentation Using Robust Feature-Based Registration -- Part V. VISCERAL Retrieval Participant Reports -- Combining Radiology Images and Clinical Meta-data for Multimodal Medical Case-based Retrieval -- Text and Content-Based Medical Image Retrieval in the VISCERAL Retrieval Benchmark.
Access
Open access
Format
e-Book
Location
Online
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Cochrane handbook for systematic reviews of interventions

https://libcat.nshealth.ca/en/permalink/provcat24276
edited by Julian PT Higgins and Sally Green. --Chichester, England: Wiley-Blackwell , 2008.
Call Number
W 20.5 C663 2008
Location
Dickson Building
Halifax Infirmary
Call Number
W 20.5 C663 2008
Corporate Author
Cochrane Collaboration
Other Authors
Higgins, Julian PT
Green, Sally
Responsibility
edited by Julian PT Higgins and Sally Green
Place of Publication
Chichester, England
Publisher
Wiley-Blackwell
Date of Publication
2008
Physical Description
649 p.
Series Title
Cochrane book series
ISBN
9780470699515
Subjects (MeSH)
Evidence-Based Medicine - methods
Meta-Analysis as Topic
Outcome and Process Assessment (Health Care)
Review Literature as Topic
Research Design
Format
Book
Location
Dickson Building
Halifax Infirmary
Copies
2
Loan Period
3 weeks
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95 records – page 1 of 5.