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Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

https://libcat.nshealth.ca/en/permalink/provcat40417

Yuji Kuge, Tohru Shiga, Nagara Tamaki, editors. --Tokyo: Springer Japan , c2016.

Available Online: View e-Book

Access: Open access

Location: Online

This work is devoted to understanding the recent advances in nuclear medicine and molecular imaging technologies along with their application to integrated medical therapy and future drug development. This anthology is based on the international symposium in 2015 entitled "Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy". The symposium provided an opportunity to exchange ideas on how to promote nuclear medicine technology and how to extend the technology to medica…

Available Online: View e-Book

Other Authors: Kuge, Yuji; Shiga, Tohru; Tamaki, Nagara

Other Authors: Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy (Symposium) (2015 : Sapporo : Japan)

Responsibility: Yuji Kuge, Tohru Shiga, Nagara Tamaki, editors

Place of Publication: Tokyo

Publisher: Springer Japan

Date of Publication: c2016

Physical Description: 1 online resource (xvi, 326 p. : 125 illus., 93 illus. in color)

ISBN: 9784431558941; 9784431558927 (print ed.)

Subjects (MeSH): Integrative Medicine; Molecular Diagnostic Techniques; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon

Specialty: Radiology; Radiotherapy

Abstract: This work is devoted to understanding the recent advances in nuclear medicine and molecular imaging technologies along with their application to integrated medical therapy and future drug development. This anthology is based on the international symposium in 2015 entitled "Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy". The symposium provided an opportunity to exchange ideas on how to promote nuclear medicine technology and how to extend the technology to medical therapy and drug development, and was also a good opportunity to discuss the future perspective of nuclear medicine and molecular imaging by worldwide leaders in the field. Molecular imaging technologies have been rapidly developed worldwide in recent years. Among those developments, nuclear medicine has come to play an important role in quantitative analysis of biological process in vivo as well as in wide clinical use. With the current progress of nuclear medicine and molecular imaging, this modality has been applied for treatment monitoring and predicting its outcome with the use of optimal imaging biomarkers and suitable quantitative analysis. Truly, a new era has arrived with clinical use of nuclear medicine and molecular imaging for personalized medicine. This volume will benefit a wide variety of researchers in life science including those working in drug development, molecular imaging, and medical therapy as well as physicians who utilize diagnostic imaging.

Contents: Part I. Instrument and Data Analysis -- 1. Advances in 4D Gated Cardiac PET Imaging for Image Quality Improvement and Cardiac Motion and Contractility Estimation -- 2. The Need for Quantitative SPECT in Clinical Brain Examinations -- 3. PET Imaging Innovation by DOI Detectors -- 4. Semiconductor Detector-Based Scanners for Nuclear Medicine -- 5. Kinetic Analysis for Cardiac PET -- Part II. Biomarker and Molecular Probes -- 6. How Far Are We from Dose On Demand of Short-Lived Radiopharmaceuticals? -- 7 Advantages of Radiochemistry in Microliter Volumes -- 8. Development of a Microreactor for Synthesis of 18F-Labeled Positron Emission Tomography Probe -- 9 Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [123I]IIMU, for Translational Research -- 10. Discovery and Evaluation of Biomarkers for Atherosclerosis -- 11. Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G -- Part III. Cardiology -- 12 Noninvasive PET Flow Reserve Imaging to Direct Optimal Therapies for Myocardial Ischemia -- 13. The Clinical Value of Cardiac PET in Heart Failure -- 14. Emerging Trends and Future Perspective of Novel Cardiac SPECT Technology -- 15. Right Ventricular Metabolism and Its Efficiency -- 16. Usefulness of 18F-FDG PET in Diagnosing Cardiac Sarcoidosis -- Part IV. Neurology -- 17. PET Quantification in Molecular Brain Imaging Taking into Account the Contribution of the Radiometabolite Entering the Brain -- 18. Hypoxia Imaging with 18F-FMISO PET for Brain Tumors -- 19. Evolution and Protection of Cerebral Infarction Evaluated by PET and SPECT -- 20. Brain Development and Aging Using Large Brain MRI Database -- Part V. Oncology -- 21. Back to the Future: Nuclear Medicine Rediscovers Its Therapeutic Roots -- 22. Interactive Communication Between PET Specialists and Oncologists -- 23. Clinical Efficacy of PET/CT Using 68Ga-DOTATOC for Diagnostic Imaging -- 24. Correlation of 40-[methyl-11C]-Thiothymidine Uptake with Ki-67 Immunohistochemistry in Patients with Newly Diagnosed and Recurrent Gliomas -- 25. Impact of Respiratory-Gated FMISO-PET/CT for the Quantitative Evaluation of Hypoxia in Non-small Cell Lung Cancer.