Cover -- Half-title -- Title -- Copyright -- Contents -- List of Contributors -- Preface -- REFERENCES -- Introduction -- What is evidence-based medicine? -- Guidelines and algorithms -- What is the evidence for evidence-based medicine? -- REFERENCES -- 1 Evidence-based pharmacotherapy of major depressive disorder -- What is the first-line pharmacotherapy of MDD? -- SSRIs in MDD -- Dual-and triple-action agents and RIMAs in MDD -- Depressive subtypes, comorbidity, and demographics -- Medical comorbidity -- Axis II comorbidity -- Anxiety disorder comorbidity -- Major depressive subtypes -- Demographics: sex -- Age -- How long should pharmacotherapy of MDD continue? -- What is the best pharmacotherapy approach to resistant MDD? -- Antidepressant switching -- Augmentation -- Conclusion -- REFERENCES -- 2 Evidence-based pharmacotherapy of bipolar disorder -- What is the first-line pharmacotherapy of acute mania? -- Lithium -- Anticonvulsants -- Neuroleptic agents -- Other agents -- ECT -- Summary of acute mania studies -- What is the first-line pharmacotherapy of acute bipolar depression? -- Lithium -- Valproate and carbamazepine -- Lamotrigine -- Other novel anticonvulsants -- Olanzapine -- Other atypical neuroleptic agents -- ECT -- Antidepressants -- Summary of acute bipolar depression studies -- What is the best pharmacotherapy approach to prophylaxis in bipolar disorder? -- Lithium -- Valproate and carbamazepine -- Lamotrigine -- Other novel anticonvulsants -- Typical neuroleptic agents -- Olanzapine -- Other atypical neuroleptic agents -- Other agents -- Standard antidepressants -- ECT -- Novel agents: omega-3 fatty acids, vitamin/mineral supplements -- Rapid-cycling bipolar disorder as a proxy for prophylaxis -- Summary of prophylaxis studies -- Acknowledgments -- REFERENCES -- 3 Evidence-based pharmacotherapy of schizophrenia -- What is the first-line pharmacotherapy of schizophrenia? -- Risperidone -- Olanzapine -- Quetiapine -- Ziprasidone -- Sertindole -- Amisulpride -- Aripiprazole -- Special populations of schizophrenia -- What is the best pharmacotherapy approach to resistant schizophrenia? -- Risperidone -- Olanzapine -- Quetiapine -- Conventional versus atypical antipsychotics:the ongoing debate -- Head-to-head comparisons of atypical antipsychotics -- Focusing on side-effect profiles -- Conclusions -- Statement of interest -- REFERENCES -- 4 Evidence-based pharmacotherapy of generalized anxiety disorder -- What is the first-line pharmacotherapy of GAD? -- Summary of published clinical trials of SSRIs and venlafaxine -- Summary of published clinical trials of other psychotropic compounds -- How long should pharmacotherapy of GAD continue? -- What is the best pharmacotherapy approach to resistant GAD? -- Conclusions -- REFERENCES -- 5 Evidence-based pharmacotherapy of panic disorder -- Introduction -- Diagnosis -- Treatment options -- Pharmacotherapy of PD --tidtid4