Cover -- Half-title -- Title -- Copyright -- Contents -- Contributors -- Preface -- REFERENCE -- Part 1 Introduction to depression and its determinants -- 1 Depression in the medically ill -- Introduction -- 'Depressive disorder' or 'depression' in the medically ill -- Depressive disorders in medical in-patients -- Depressive disorders in medical out-patients and primary care -- Population-based studies -- Consequences of depressive disorder in people with physical illness -- REFERENCES -- 2 Psychosocial factors, depression and illness -- Introduction -- Sociodemographic factors -- Life events, chronic strain and major difficulties -- Social support -- Ethnicity and depression -- Work and depression -- Psychosocial risk factors and depression in the elderly -- Associations of psychosocial factors with depression and physical illness -- REFERENCES -- Part 2 Depression and specific health problems -- 3 Depression and the development of coronary heart disease -- Introduction -- CHD in patients with clinical depression -- Endothelial function and vascular inflammation -- Haemostatic processes and platelet function -- Neuroendocrine and autonomic function -- Limitations to studies of mechanisms -- Conclusions -- Acknowledgements -- REFERENCES -- 4 Depression and prognosis in cardiac patients -- Depression and CHD outcomes -- Biobehavioural mechanisms -- Conclusions -- REFERENCES -- 5 The management of depression in patients with coronary heart disease -- Introduction -- Effects of depression in cardiac patients -- Treatments for depression -- Treating depression in order to reduce medical morbidity and mortality in CHD -- Summary and conclusions -- Acknowledgements -- REFERENCES -- 6 Depression and physical disability -- Disability: a functional indicator of physical health -- Describing the link between disability and depression -- Explaining the link between depression and disability -- Intervening to break the link between depression and disability -- Summary and conclusions -- REFERENCES -- 7 Chronic pain and depression: twin burdens of adaptation -- Introduction -- Psychoneuroimmunological developments -- Pain, depression and the immune system -- Chronicity: the role of sensitisation -- Resilience -- Conclusion -- REFERENCES -- 8 The interrelationship of depression and diabetes -- Introduction: diabetes -- Epidemiology -- Biology -- Treatment of depression in patients with diabetes -- Future directions for research -- Acknowledgements -- REFERENCES -- 9 Depression and chronic fatigue -- Introduction -- Epidemiology of fatigue -- Chronic fatigue syndrome -- Fatigue as part of depressive illness -- Is chronic fatigue syndrome a subclinical depressive illness? -- Fatigue and depression following infections -- Vital exhaustion and ischaemic heart disease -- Pathophysiology discriminates fatigue and depression -- Treatment similarities and differences between fatigue and depression -- Secondary fatigue -- Conclusions -- REFERENCES -- 10 Cancer and depression -- Introduction -- Prevalence of depression among cancer patients -- Dilemmas in the diagnosis and assessment of depression in cancer patients -- Detection and treatment of depression in cancer patients -- Depression and cancer incidence, progression and surviv