oncogenes found 11 records - Provincial Hospitals Library Catalogue

The Molecular Basis of Human Cancer

https://libcat.nshealth.ca/en/permalink/provcat41240

William B. Coleman, Gregory J. Tsongalis, editors. (Second edition) --New York, NY: Humana Press , 2017.

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Location: Online

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter t…

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Other Authors: Coleman, William B; Tsongalis, Gregory J

Responsibility: William B. Coleman, Gregory J. Tsongalis, editors

Edition: Second edition

Place of Publication: New York, NY

Publisher: Humana Press

Date of Publication: 2017

Physical Description: 1 online resource (xix, 873 pages) : 217 illus., 120 illus. in color

ISBN: 9781597454582; 9781934115183 (print ed.)

Subjects (MeSH): Carcinogenesis; Cell Transformation, Neoplastic - genetics; Mutation; Neoplasms - genetics

Abstract: This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.

Contents: Cancer Epidemiology: Incidence and Etiology of Human Neoplasms -- Essential Concepts and Techniques in Molecular Biology -- Cancer Genomics -- Cancer Cytogenetics -- The Epigenetic Basis of Human Cancer -- Cancer Proteomics -- An Overview of Cancer Genes -- Oncogenes and the Initiation and Maintenance of Tumorigenesis -- Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors -- Senescence, Apoptosis, and Cancer -- Novel Cancer Therapies Targeting Angiogenesis -- Beyond the Primary Tumor: Progression, Invasion, and Metastasis -- Simple Sequence Mutations -- Single Nucleotide Polymorphisms and Cancer Susceptibility -- Chromosomes and Chromosomal Instability in Human Cancer -- Epigenetic Mechanisms in Cancer Development -- MicroRNAs and Cancer -- Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas -- Viral Mechanisms in Human Carcinogenesis -- Hormonal Carcinogenesis: The Role of Estrogens -- Sporadic Cancers -- Hereditary Cancer -- Retinoblastoma: Clinical and Molecular Perspectives -- Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light -- Hereditary Colorectal Cancer -- Hereditary Breast and Ovarian Cancer -- The Molecular Basis of Prostate Carcinogenesis -- Molecular Basis of Lung Carcinogenesis -- The Molecular Basis of Skin Carcinogenesis -- The Molecular Biology of Leukemias -- Molecular Mechanisms in Non-Hodgkin Lymphoma -- The Molecular Pathology of Head and Neck Squamous Cell Carcinoma -- Ovarian Cancer -- Molecular Pathology of Bone and Soft Tissue Tumors -- The Molecular Biology of Human Brain Tumors -- Cancer Drug Discovery and Anticancer Drug Development -- Biological Principles and Clinical Application of EGFR Inhibitors in Cancer -- Targeting Oncoproteins for Molecular Cancer Therapy -- Therapeutic Agents that Inhibit Angiogenesis -- Small Molecule Inhibitors -- Molecular Detection and Diagnosis of Cancer -- Gene Therapy in the Treatment of Human Cancer -- Personalized Medicine for the Treatment of Human Cancer.

Format: e-Book

Location: Online

Thyroid Cancer : A Comprehensive Guide to Clinical Management

https://libcat.nshealth.ca/en/permalink/provcat39714

Leonard Wartofsky, Douglas Van Nostrand, editors. (Third edition) --New York, NY: Springer , c2016.

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Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Vari…

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Other Authors: Wartofsky, Leonard; Van Nostrand, Douglas

Responsibility: Leonard Wartofsky, Douglas Van Nostrand, editors

Edition: Third edition

Place of Publication: New York, NY

Publisher: Springer

Date of Publication: c2016

Physical Description: 1 online resource (xxxi, 1049 p. : 271 illus., 81 illus. in color)

ISBN: 9781493933143; 9781493933129 (print ed.)

Subjects (MeSH): Thyroid Neoplasms

Abstract: Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the fieldÇÖs leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer.

Contents: PART I. GENERAL CONSIDERATIONS I: THYROID CANCER -- 1 Anatomy and Physiology of the thyroid gland: Clinical Correlates to Thyroid Cancer -- 2 Epidemiology of Thyroid Cancer -- 3 Molecular Pathogenesis of Thyroid Cancer & Oncogenes in Thyroid Cancer -- 4 Molecular Aspects of Thyroid Cancer in Children -- 5 The Role of Genetics in the Development of Familial Non-Medullary Thyroid Cancer -- 6 Apoptosis in Thyroid Cancer -- 7 Radiation-Induced Thyroid Cancer -- 8 Classification of Thyroid Malignancies -- 9 Staging of Thyroid Cancer -- 10 Recombinant human Thyrotropin (Thyrogen’) -- PART II. GENERAL CONSIDERATIONS II: NUCLEAR MEDICINE -- 11 Radioiodine Whole Body Imaging -- 12 Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy -- 13 False-Positive Radioiodine-131 scans in Thyroid Cancer -- 14 The Utility of SPECT-CT in Differentiated Thyroid Cancer -- 15 Radioiodine scintigraphy with SPECT/CT: an important diagnostic tool for staging and risk stratification -- 16 Stunning by 131I scanning: Untoward Effect of 131I Thyroid Imaging Prior to Radioablation Therapy -- 17 Stunning is Not a Problem -- 18 Stunning: Does it Exist? A Commentary -- 19 To Perform or Not to Perform Radioiodine Scans Prior to 131I Remnant Ablation? -- PART III. THE THYROID NODULE -- 20 The Thyroid Nodule: Evaluation, Risk of Malignancy, and Management -- 21 Fine-Needle Aspiration -- 22 Diagnostic and Prognostic Molecular Markers in Thyroid Cancer -- 23 Ultrasonic Imaging of the Thyroid Gland -- 24 Radionuclide Imaging of Thyroid Nodules -- 25 18F Fluoro-deoxyglucose PET and Thyroid Nodules -- 26 Thyroid Nodules and Cancer Risk: Surgical Management -- 27 Thyroid Nodules in Children and Cancer Risk -- 28 Management of the Thyroid Nodule: A Comparison Of Published International Guidelines -- PART IV. WELL-DIFFERENTIATED THYROID CANCER A: PAPILLARY CARCINOMA: PRESENTATION -- 29 Papillary Carcinoma: Clinical Aspects -- 30 Papillary Microcarcinoma -- 31 Surgical Approach to Papillary Thyroid Cancer -- 32 Papillary Carcinoma: Cytology and Pathology -- B. INITIAL MANAGEMENT -- 33 Remnant Ablation, Adjuvant Treatment and Treatment of Locoregional Metastases with 131I -- 34 Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin -- C. SURVEILLANCE -- 35 Follow-up Strategy in Papillary Thyroid Cancer -- 36 Thyroid Hormone Therapy and Thyrotropin Suppression -- 37 Thyroglobulin for Differentiated Thyroid Cancer: Measurement and Interferences -- 38 Thyroglobulin Antibodies and Their Measurement -- 39 Diagnosis of Recurrent Thyroid Cancer in Patients with Anti-Thyroglobulin Antibodies -- 40 Ultrasound of the neck lymph nodes -- 41 Surveillance Radioiodine Whole Body Scans -- 42 Radionuclide Imaging and Treatment of Children with Thyroid Cancer -- 43 Positron Emission Tomography-/Computed Tomography (PET-CT and PET) in Well-Differentiated Thyroid Cancer -- 44 Alternative Thyroid Imaging -- 45 MR and CT Imaging of Thyroid Cancer -- 46 Thyroglobulin in Lymph Node Aspirate -- 47 Management of the Patients with Negative Radioiodine Scan and Elevated Serum Thyroglobulin -- 48 Prognosis in Papillary Thyroid Cancer -- 49 Surgical Management of Lymph Node Metastases -- 50 Utility of Second Surgery for Lymph Node Metastases -- 51 Papillary Cancer Special Aspects in Children -- 52 Special Presentations of Thyroid Cancer in Thyrotoxicosis, Renal Failure, and Struma Ovarii -- 53 Thyroglossal Duct Carcinoma -- 54 Thyroid Cancer in Pregnancy -- D. TREATMENT -- 55 Radiation and Radioactivity -- 56 131I Treatment of Distant Metastases -- 57 Treatment of Metastatic Thyroid Cancer with Radioiodine following preparation by Recombinant Human Thyrotopin -- 58 Dosimetrically-Determined Prescribed Activity of 131I for the Treatment of Metastatic Differentiated Thyroid Carcinoma -- 59 Simplified Methods of Dosimetry -- 60 Radioiodine Dosimetry with Recombinant human Thyrotropin -- 61 The Use of Lithium as an Adjuvant to Radioiodine In the Treatment of Thyroid Cancer -- 62 Side Effects of 131I for Therapy of Differentiated Thyroid Carcinoma -- 63 Radiation Therapy in Papillary Carcinoma -- 64 Chemotherapy of Thyroid Cancer: General Principles -- 65 Bone Metastases from Differentiated Thyroid Carcinoma -- 66 A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer -- 67 Adjunctive Local Approaches to Thyroid Nodules and Metastatic Thyroid Cancer -- 68 Radioiodine-Refractory Thyroid Cancer: Restoring Response to Radioiodine Therapy -- 69 Alternative and Complementary Treatment of Thyroid Disorders -- PART V. WELL-DIFFERENTIATED THYROID CANCER FOLLICULAR CARCINOMA -- 70 Follicular Thyroid Carcinoma -- 71 Surgical Management of Follicular Cancer -- 72 Pathology of Follicular Cancer -- 73 H©rthle Cell Carcinoma -- 74 Follow-Up Strategy in Follicular Thyroid Cancer -- 75 Radionuclide Imaging and 131I Therapy in Follicular Thyroid Carcinoma -- 76 PET/CT in Follicular Cancer Including H©rthle Cell Cancer -- 77 Follicular Thyroid Cancer: Special Aspects in Children and Adolescents -- 78 External Radiation Therapy of Follicular Carcinoma -- 79 Determinants of Prognosis of Follicular Thyroid Carcinoma -- PART VI. VARIANTS OF THYROID CANCER -- 80 Aggressive Variants of Papillary Thyroid Carcinoma and Poorly Differentiated Carcinoma -- 81 Miscellaneous and Unusual Tumors of the Thyroid Gland -- 82 Pathology of Miscellaneous and Unusual Tumors of the Thyroid Gland -- PART VII. UNDIFFERENTIATED TUMORS: MEDULLARY THYROID CARCINOMA -- 83 Clinical Aspects of Medullary Thyroid Carcinoma -- 84 Cytology and Pathology of Medullary Carcinoma -- 85 Medullary Carcinoma of the Thyroid: Surgical Management -- 86 Radionuclide Imaging of Medullary Carcinoma -- 87 PET/CT in Medullary Thyroid Cancer -- 88 Radiation Therapy in Medullary Cancer -- 89 Medullary Carcinoma of the Thyroid: Chemotherapy -- 90 A Comparison of the ATA, NCCN, ETA, and BTA Guidelines for the Management of Medullary Thyroid Cancer -- PART VIII. UNDIFFERENTIATED TUMORS: THYROID LYMPHOMA -- 91 Thyroid Lymphoma -- 92 Pathology of Lymphoma of the Thyroid -- 93 PET/CT in Lymphoma and Lymphoma of the Thyroid -- PART IX. UNDIFFERENTIATED TUMORS: ANAPLASTIC THYROID CANCER -- 94 Anaplastic Thyroid Carcinoma: Clinical Aspects -- 95 Surgical Management of Anaplastic Thyroid Carcinoma -- 96 Pathology of Anaplastic Carcinoma -- 97 PET/CT in Anaplastic Cancer of the Thyroid -- 98 Anaplastic Thyroid Cancer -- 99 Chemotherapy for Anaplastic Thyroid Cancer -- 100 Anaplastic Thyroid Carcinoma: Prognosis -- PART X. NEW FRONTIERS AND FUTURE DIRECTIONS -- 101 Advances in Radiation Therapy -- 102 New Approaches in Nuclear Medicine for Thyroid Cancer -- 103 124I in Differentiated Thyroid Cancer -- 104 Future Directions for Advanced Thyroid Cancer Therapy -- 105 Potential Approaches to Chemotherapy of Thyroid Cancer in the Future -- PART XI. ASSITIONAL RESOURCES -- 106 Prophylaxis against Radiation Exposure from Radioiodine -- 107 Low Iodine Diets -- Appendix A: Books and Manuals -- Appendix B: Additional Sources of Information: Support groups, Websites and additional information -- Appendix C: Forms and Instructions for Patients Treated with Radioactivity.

Format: e-Book

Location: Online

Precision Molecular Pathology of Breast Cancer

https://libcat.nshealth.ca/en/permalink/provcat39035

Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors. (1st ed.) --New York, NY: Springer , c2015.

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This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters pre…

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Other Authors: Khan, Ashraf; Ellis, Ian O; Hanby, Andrew M; Cosar, Ediz F; Rakha, Emad A; Kandil, Dina

Responsibility: Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil, editors

Edition: 1st ed.

Place of Publication: New York, NY

Publisher: Springer

Date of Publication: c2015

Physical Description: 1 online resource (x, 338 p. : 29 illus., 28 illus. in color)

Series Vol.: 10

Series Title: Molecular pathology library

ISBN: 9781493928866; 9781493928859 (print ed.)

ISSN: 1935-987X

Subjects (MeSH): Breast neoplasms - pathology; Molecular Diagnostic Techniques; Molecular Targeted Therapy; Pathology, Molecular - methods

Abstract: This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Contents: Molecular basis of breast cancer imaging -- Familial Breast Cancer and Genetic Predisposition in Breast Cancer -- Modelling the Molecular Pathology of Breast Cancer Initiation -- Molecular Pathology of Precancerous Lesions of the Breast -- Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted Therapy -- Molecular Pathology of Pre-Invasive Ductal Carcinoma -- Molecular Pathology of Lobular Carcinoma -- Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic Implications -- Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy -- Molecular Classification of Breast Cancer -- Triple-Negative Breast Cancer: Subtypes with Clinical Implications -- Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast Cancer -- Role of MicroRNAs in Breast Cancer -- Molecular Pathology of Fibroepithelial Neoplasms of the Breast -- Molecular Features of Mesenchymal Tumors of the Breast -- Molecular Pathology of Breast Cancer Metastasis -- The molecular pathology of chemoresistance during the therapeutic response in breast cancer -- The Molecular Pathology of Male Breast Cancer -- Specimens for Molecular Testing in Breast Cancer.

Format: e-Book

Location: Online

Chromosomal Instability in Cancer Cells

https://libcat.nshealth.ca/en/permalink/provcat39360

B. Michael Ghadimi, Thomas Ried, editors. (1st ed.) --Cham: Springer , c2015.

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Location: Online

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which chan…

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Other Authors: Ghadimi, B. Michael; Ried, Thomas

Responsibility: B. Michael Ghadimi, Thomas Ried, editors

Edition: 1st ed.

Place of Publication: Cham

Publisher: Springer

Date of Publication: c2015

Physical Description: 1 online resource (vii, 224 p. : 39 illus. in color)

Series Vol.: 200

Series Title: Recent results in cancer research

ISBN: 9783319202914; 9783319202907 (print ed.)

ISSN: 0080-0015

Subjects (MeSH): Aneuploidy; Chromosomal Instability - genetics; Gene Expression Regulation, Neoplastic - genetics; Neoplasms - genetics; Translocation, Genetic

Abstract: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Contents: DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The Diverse Effects of Complex Chromosome Rearrangements and Chromothripsis in Cancer Development. -- Consequences of Aneuploidy in Cancer: Transcriptome and Beyond.

Format: e-Book

Location: Online

Omics approaches in breast cancer : towards next-generation diagnosis, prognosis, and therapy

https://libcat.nshealth.ca/en/permalink/provcat33369

Debmalya Barh, editor. --New Delhi: Springer , c2014.

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Location: Online

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Other Authors: Barh, Debmalya

Responsibility: Debmalya Barh, editor

Place of Publication: New Delhi

Publisher: Springer

Date of Publication: c2014

Physical Description: 1 online resource

ISBN: 9788132208433 (electronic bk.); 9788132208426

Subjects (MeSH): Breast Neoplasms - diagnosis; Breast neoplasms - genetics; Genomics; Molecular medicine

Subjects (LCSH): Breast - Cancer

Contents: Part I. Omics Approaches in Breast Cancer -- 1 Omics Technologies Applied in Breast Cancer Research -- 2 Omics of Hereditary Breast Cancer -- 3 Oncogenes and Tumor Suppressor Genes as a Biomarker in Breast Cancer -- 4 Breast Cancer Genomics -- 5 Epigenomics of Breast Cancer -- 6 Nutrigenomics in Breast Cancer -- 7 Long Noncoding RNAs in Breast Cancer: Implications for Pathogenesis, Diagnosis, and Therapy -- 8 Breast Cancer MicroRNAs: Clinical Biomarkers for the Diagnosis and Treatment Strategies -- 9 Breast Cancer Proteomics -- 10 Metabolomics in Breast Cancer -- 11 Lipidomics in Breast Cancer -- 12 Breast Cancer Stem Cells and Cellomics -- 13 Omics of Male Breast Cancer -- 14 Omics of Chemoresistant and Metastatic Breast Cancer -- 15 Animal Models of Breast Cancer -- 16 In Silico Disease Models of Breast Cancer -- 17 Systems Biology and Integrative Omics in Breast Cancer -- Part II. Breast Cancer: Next-Generation Diagnosis, Prognosis, and Therapy -- 18 Gynecologic Considerations for Women with Breast Cancer -- 19 Imaging Technologies and Applications in Early Diagnosis and Prognosis for Breast Cancer -- 20 Breast Cancer Biomarkers for Risk Assessment, Screening, Detection, Diagnosis, and Prognosis -- 21 Breast Circulating Tumor Cells: Potential Biomarkers for Breast Cancer Diagnosis and Prognosis Evaluation -- 22 Molecular Diagnosis of Metastasizing Breast Cancer Based Upon Liquid -- 23 Exhaled Volatile Organic Compounds as Noninvasive Markers in Breast Cancer -- 24 Breast Cancer Therapy: Classical Therapy, Drug Targets, and Targeted Therapy -- 25 Pharmacogenomics–Pharmacoepigenomics of Breast Cancer Therapy: Clinical Implications -- 26 Breast Cancer Gene Therapy -- 27 Clinical Trial Endpoints in Breast Cancer.

Format: e-Book

Location: Online

Molecular diagnostics for dermatology : practical applications of molecular testing for the diagnosis and management of the dermatology patient

https://libcat.nshealth.ca/en/permalink/provcat34017

Gregory A. Hosler, Kathleen M. Murphy. --Heidelberg: Springer , c2014.

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This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensiv…

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Author: Hosler, Gregory A.

Other Authors: Murphy, Kathleen M.

Responsibility: Gregory A. Hosler, Kathleen M. Murphy

Place of Publication: Heidelberg

Publisher: Springer

Date of Publication: c2014

Physical Description: 1 online resource (xviii, 356 pages)

ISBN: 9783642540660 (electronic bk.); 9783642540653

Subjects (MeSH): Molecular Diagnostic Techniques; Skin Diseases - diagnosis

Subjects (LCSH): Skin - Diseases - Molecular diagnosis; Dermatology; Médecine

Abstract: This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers - clinicians, pathologists, laboratorians, and other inquisitive minds - independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto-oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, replacing 'excise and pray' approaches with personalized medicine.

Contents: 1. Introduction -- 2. Basics of Nucleic Acids and Molecular Biology -- 3. Molecular Methods -- 4. Melanoma. Part I. Risk Assessment, Diagnosis, and Prognosis: Using Molecular Tools to Diagnose Melanoma, Predict Its Behavior, and Evaluate for Inheritable Forms -- 5. Melanoma. Part II. Personalized Medicine: Using Molecular Tools to Guide Targeted Therapy -- 6. Leukemia and Lymphoma. Part I. Mycosis Fungoides and Sézary Syndrome: Using Molecular Tools to Aid in the Diagnosis, Staging, and Therapy for Mycosis Fungoides and Sézary Syndrome -- 7. Leukemia and Lymphoma. Part II: Primary Cutaneous B-Cell Lymphoma and Other Non-MF/SS HematopoieticTumors -- 8. Tumors of the Soft Tissue: Using Molecular Tools to Aid in the Diagnosis of Soft Tissue Tumors and the Management of the Sarcoma Patient -- 9. Genodermatoses. Part I: Muir- Torre Syndrome -- 10. Genodermatoses. Part II: Other Hereditary Dermatologic Disease -- 11. Infectious Disease Testing -- 12. Emerging Molecular Applications and Summary -- Appendix.

Format: e-Book

Location: Online

Autophagy and cancer

https://libcat.nshealth.ca/en/permalink/provcat32578

Hong-Gang Wang, editor. --New York, NY: Springer , c2013.

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This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction …

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Other Authors: Wang, Hong-Gang

Responsibility: Hong-Gang Wang, editor

Place of Publication: New York, NY

Publisher: Springer

Date of Publication: c2013

Physical Description: 1 online resource (xi, 261 p. : 33 ill., 29 ill. in color)

Series Title: Current cancer research

ISBN: 9781461465614

Subjects (MeSH): Autophagy; Neoplasms

Subjects (LCSH): Medicine; Oncology; Human physiology; Cytology

Abstract: This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.

Contents: Preface -- Historical Overview of Autophagy -- The Core Molecular Machinery of Autophagosome Formation -- The origin of autophagosomes: The beginning of an end -- Signal Transduction Regulation of Autophagy -- Role of Autophagy in Tumorigenesis -- Selective autophagy and cancer -- Oncogenes and tumor suppressor genes in autophagy -- Autophagy and Immunity -- Autophagy and the Tumor Microenvironment -- Autophagy and Cancer Therapy -- The Crosstalk between Apoptosis & Autophagy -- Autophagy and Cancer Drug Discovery -- Index.

Format: e-Book

Location: Online

RNA and cancer

https://libcat.nshealth.ca/en/permalink/provcat32612

Jane Y. Wu, editor. --Berlin, Heidelberg: Springer , c2013.

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Location: Online

In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life. This book reviews recent progress in selected areas of RNA processing in which information of particular relevance to cancer development and therapy has been obtained. It opens by examining the coupling betwee…

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Other Authors: Wu, Jane Y

Responsibility: Jane Y. Wu, editor

Place of Publication: Berlin, Heidelberg

Publisher: Springer

Date of Publication: c2013

Physical Description: 1 online resource (xiii, 245 p. : 23 ill., 5 ill. in color)

Series Title: Cancer treatment and research

ISBN: 9783642316593

Subjects (MeSH): Neoplasms - genetics; RNA - genetics

Subjects (LCSH): Medicine; Oncology; Human genetics; Biochemistry

Abstract: In the last decade, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. Rather, it has multiple, versatile functional roles in cells, especially in mammalian gene regulation, and thereby influences almost every aspect of cellular life. This book reviews recent progress in selected areas of RNA processing in which information of particular relevance to cancer development and therapy has been obtained. It opens by examining the coupling between transcription and splicing. Three subsequent chapters describe in detail cancer-associated aberrant RNAs, new methodology for their detection, and the functional impact on expression of important genes, including oncogenes and tumor suppressor genes. Further topics include the role of microRNAs in cancer and the possible involvement of the perinucleolar compartment. The implications for cancer of regulation of mRNA stability by cellular signaling are discussed, and the importance of splicing defects in the regulation of cell death genes is examined. The potential for the development of oligonucleotide therapeutics is then reviewed before the final chapter considers clinical perspectives on the study of RNA defects in cancer.All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers, leading to improved cancer diagnosis and treatment.

Contents: Coupling between transcription and alternative splicing -- Detection of alternatively spliced or processed RNAs in cancer using oligonucleotide microarray -- Cancer-associated perturbations in alternative pre-messenger RNA splicing -- Alternative splicing of tumor suppressors and oncogenes -- MicroRNAs in cancer -- The perinucleolar compartment: RNA metabolism and cancer -- Regulation of ARE-mRNA stability by cellular signaling: implications for human cancer -- Alternative pre-mRNA splicing, cell death and cancer -- Oligonucleotide therapeutics in cancer -- Clinical perspective on chemo-resistance and the role of RNA processing.