Skip header and navigation

1 records – page 1 of 1.

Lipid Nanoparticles : Production, Characterization and Stability

https://libcat.nshealth.ca/en/permalink/provcat39117
Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding. --Cham: Springer , c2015.
Available Online
View e-Book
Location
Online
What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive descripti…
Available Online
View e-Book
Author
Shah, Rohan
Other Authors
Eldridge, Daniel
Palombo, Enzo
Harding, Ian
Responsibility
Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding
Place of Publication
Cham
Publisher
Springer
Date of Publication
c2015
Physical Description
1 online resource (ix, 97 p. : 30 illus., 18 illus. in color)
Series Title
SpringerBriefs in pharmaceutical science & drug development
ISBN
9783319107110
9783319107103 (print ed.)
ISSN
1864-8118
Subjects (MeSH)
Biomedical Engineering
Lipids
Nanoparticles
Nanotechnology
Abstract
What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive description of the current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems. Nanoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. The work provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure. Current thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed. The many techniques for production, including the author's own variant of microwave heating, are fully discussed. Techniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity. Finally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. This work appeals to students of colloid science, practitioners of research into drug delivery and academics alike.
Contents
Introduction -- Composition and structure -- Production techniques -- Characterization -- Physicochemical stability.
Format
e-Book
Location
Online
Less detail