Medical terminology basics : programmed instruction
https://libcat.nshealth.ca/en/permalink/provcat32970
Y.H. Hui.
--Sudbury, MA:
Jones and Bartlett Publishers
, c2010.
- Available Online
- View e-Book
- Location
- Online
- Available Online
- View e-Book
- Author
- Hui, Y. H
- Responsibility
- Y.H. Hui
- Place of Publication
- Sudbury, MA
- Publisher
- Jones and Bartlett Publishers
- Date of Publication
- c2010
- Physical Description
- 1 online resource (xiv, 449 p.)
- ISBN
- 9781449610623
- Subjects (MeSH)
- Terminology as Topic - Programmed Instruction
- Contents
- pt. 1. The fundamentals of personalized instruction programs -- pt. 2. Programmed instruction for medical terminology related to body systems.
- Format
- e-Book
- Location
- Online
Hematologic Malignancies : Hodgkin Lymphoma : A Comprehensive Update on Diagnostics and Clinics
https://libcat.nshealth.ca/en/permalink/provcat29932
Andreas Engert, Sandra J. Horning, editors.
--Berlin, Heidelberg:
Springer
, c2011.
- Available Online
- View e-Book
- Location
- Online
This book provides a well-illustrated, comprehensive, and up-to-date account of Hodgkin lymphoma. Epidemiology, pathogenesis, and the role of the microenvironment are examined in detail. The initial clinical evaluation and use of staging systems are fully discussed, and prognostic factors are carefully considered. The various treatment options for first-line and relapsed Hodgkin lymphoma are presented, including the newly available treatments for recurrent disease and the management required in…
- Available Online
- View e-Book
- Other Authors
- Engert, Andreas
- Horning, Sandra J
- Responsibility
- Andreas Engert, Sandra J. Horning, editors
- Alternate Title
- Hodgkin lymphoma
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2011
- Physical Description
- 1 online resource (ix, 381 p. : 77 illus., 47 illus. in color)
- Series Title
- Hematologic malignancies (Series)
- ISBN
- 9783642127809
- Subjects (MeSH)
- Hodgkin disease - diagnosis
- Hodgkin disease - therapy
- Subjects (LCSH)
- Hematology
- Oncology
- Abstract
- This book provides a well-illustrated, comprehensive, and up-to-date account of Hodgkin lymphoma. Epidemiology, pathogenesis, and the role of the microenvironment are examined in detail. The initial clinical evaluation and use of staging systems are fully discussed, and prognostic factors are carefully considered. The various treatment options for first-line and relapsed Hodgkin lymphoma are presented, including the newly available treatments for recurrent disease and the management required in special clinical circumstances. Given the very high cure rates and the young age of many patients, there is an increasing need to develop better individually tailored treatment strategies that will help to avoid both early and late side-effects of treatment. Such strategies receive due attention, and clear guidance is provided on the handling of Hodgkin survivors. This book will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.
- Contents
- Part I. From Hodgkin’s Disease to Hodgkin Lymphoma -- 1. Epidemiology -- 2. The Role of Viruses in the Genesis of Hodgkin Lymphoma -- 3. Pathology and Molecular Pathology of Hodgkin Lymphoma -- 4. Microenvironment, Cross-Talk, and Immune Escape Mechanisms -- Part II. Diagnosis and Treatment -- 5. Clinical Evaluation -- 6. Functional Imaging -- 7. Prognostic Factors -- 8. Principles of Radiation Techniques in Hodgkin Lymphoma -- 9. Principles of Chemotherapy in Hodgkin Lymphoma -- 10. Treatment of Early Favorable Hodgkin Lymphoma -- 11. Treatment of Early Unfavorable HL -- 12. Treatment of Advanced Stage Hodgkin Lymphoma -- 13. Relapsed and Refractory Hodgkin Lymphoma -- 14. Pediatric Hodgkin Lymphoma -- Part III. Special Clinical Situations -- 15. Lymphocyte-Predominant Hodgkin Lymphoma -- 16. The Management of Hodgkin Lymphoma During Pregnancy -- 17. The Management of HIV-Hodgkin Lymphoma -- 18. The Management of Elderly Patients with Hodgkin Lymphoma -- 19. Allogeneic Transplantation for Relapsed Hodgkin Lymphoma -- 20. New Agents for Patients with Hodgkin Lymphoma -- Part IV. Survivorship -- 21. Quality of Life in Hodgkin Lymphoma -- 22. Second Malignancy Risk After Treatment of Hodgkin Lymphoma -- 23. Cardiovascular and Pulmonary Late Effects -- 24. Gonadal Dysfunction and Fertility Preservation in Hodgkin Lymphoma Patients -- Part V. Future Prospects -- 25. What Will We Learn from Genomics and Proteomics in Hodgkin Lymphoma? -- 26. Personalized Medicine in Hodgkin Lymphoma?
- Format
- e-Book
- Location
- Online
Heal your back : your complete prescription for preventing, treating, and eliminating back pain
https://libcat.nshealth.ca/en/permalink/provcat32953
David Borenstein.
--Lanham, MD:
M. Evans
, c2011.
- Available Online
- View e-Book
- Location
- Online
Heal Your Back is a complete program for understanding the causes of lower back pain, the ways to prevent it, and the treatments to eliminate it. The book educates readers about all aspects of back pain and shows them how to create their own personalized"prescription" for alleviating the pain and preventing further back problems. While other books recommend a specific type of treatment, Heal Your Back includes exercises and nutrition advice, and information on chiropractic therapy, acupuncture…
- Available Online
- View e-Book
- Author
- Borenstein, David
- Responsibility
- David Borenstein
- Place of Publication
- Lanham, MD
- Publisher
- M. Evans
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xvii, 276 p.)
- ISBN
- 9781590771853
- Subjects (MeSH)
- Back Pain - therapy
- Back Pain - prevention & control
- Abstract
- Heal Your Back is a complete program for understanding the causes of lower back pain, the ways to prevent it, and the treatments to eliminate it. The book educates readers about all aspects of back pain and shows them how to create their own personalized"prescription" for alleviating the pain and preventing further back problems. While other books recommend a specific type of treatment, Heal Your Back includes exercises and nutrition advice, and information on chiropractic therapy, acupuncture, medicines, and surgery. Dr. Borenstein's self-care program allows sufferers to control their own recovery.
- Contents
- Acknowledgments; Introduction: One Big Sneeze Can Do You In and the Twist and Shout; Part I. TAKING THE MYSTERY OUT OF LOW BACK PAIN; Chapter 1. Understanding Why Your Back Hurts; Chapter 2. Working with Your Doctor; Chapter 3. What Diagnostic Tests Can -- and Cannot -- Tell You; Part II. KNOWING YOUR TREATMENT OPTIONS; Chapter 4. The Basic Back Pain Relief Program; Chapter 5. Recognizing and Treating Mechanical Low Back Pain; Chapter 6. Recognizing and Treating Medical Causes of Low Back Pain; Chapter 7. How Can I Keep from Getting Bent Over?
- Format
- e-Book
- Location
- Online
Tumors of the Central Nervous System. Vol. 1, Gliomas, Glioblastoma (Part 1)
https://libcat.nshealth.ca/en/permalink/provcat40903
edited by M. A. Hayat.
--Dordrecht:
Springer
, c2011.
- Available Online
- View e-Book
- Location
- Online
The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical …
- Available Online
- View e-Book
- Other Authors
- Hayat, M. A
- Responsibility
- edited by M. A. Hayat
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2011
- Physical Description
- 1 online resource (xxi, 434 p.)
- Series Vol.
- v. 1
- Series Title
- Tumors of the central nervous system
- ISBN
- 9789400703445
- 9789400703438 (print ed.)
- Subjects (MeSH)
- Antineoplastic Agents - therapeutic use
- Biomarkers
- Brain neoplasms - diagnosis
- Brain neoplasms - therapy
- Glioblastoma - diagnosis
- Glioblastoma - therapy
- Glioma - diagnosis
- Glioma - therapy
- Abstract
- The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed.
- Contents
- Part I. Introduction -- 1. Introduction -- 2. Molecular Classification of Gliomas -- Part II. Biomarkers and Diagnosis -- 3. Glioblastoma: Endosialin Marker for Pericytes -- 4. Glioma Grading Using Cerebral Blood Volume Heterogeneity -- 5. The Role of Ectonucleotidases in Glioma Cell Proliferation -- 6. Gliomas: Role of Monoamine Oxidase B in Diagnosis -- 7. Glioma: Role of Integrin in Pathogenesis and Therapy -- 8. Proton Magnetic Resonance Spectroscopy in Intracranial Gliomas -- 9. Infiltration Zone in Glioma: Proton Magnetic Resonance Spectroscopic Imaging -- 10. Malignant Gliomas: Role of E2F1 Transcription Factor -- 11. The Role of Glucose Transporter-1 (GLUT-1) in Malignant Gliomas -- 12. Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA) -- 13. Molecular Methods for Detection of Tumor Markers in Glioblastomas -- 14. Role of MGMT in Glioblastomas -- 15. Glioblastomas: Role of CXCL12 Chemokine -- 16. Cell Death Signaling in Glioblastoma Multiforme: Role of the Bcl2L12 Oncoprotein -- 17. Glioblastoma Multiforme: Role of Polycomb Group Proteins -- 18. Glioblastoma Multiforme: Role of Cell Cycle-Related Kinase Protein (Method) -- Part III. Neural Stem Cells and Cancer Stem Cells -- 19. Markers of Stem Cells in Gliomas -- 20. Efficient Derivation and Propagation of Glioblastoma Stem-Like Cells Under Serum-Free Conditions Using the Cambridge Protocol -- 21. Glioma Cell Lines: Role of Cancer Stem Cells -- 22. Glioblastoma Cancer Stem Cells: Response to Epidermal Growth Factor Receptor Kinase Inhibitors -- Part IV. Therapy -- 23. Low- and High-Grade Gliomas: Extensive Surgical Resection -- 24. Brainstem Gangliogliomas: Total Resection and Close Follow-Up -- 25. Glioblastoma: Temozolomide-Based Chemotherapy -- 26. Drug-Resistant Glioma: Treatment with Imatinib Mesylate and Chlorimipramine -- 27. Glioblastoma Multiforme: Molecular Basis of Resistance to Erlotinib -- 28. Enhanced Glioma Chemosensitivity -- 29 Malignant Glioma Patients: Anti-Vascular Endothelial Growth Factor Monoclonal Antibody, Bevacizumab -- 30. Aggravating Endoplasmic Reticulum Stress by Combined Application of Bortezomib and Celecoxib as a Novel Therapeutic Strategy for Glioblastoma -- 31. Targeted Therapy for Malignant Gliomas -- 32. Glioblastomas: HER1/EGFR-Targeted Therapeutics -- 33. Epidermal Growth Factor Receptor Inhibition as a Therapeutic Strategy for Glioblastoma Multiforme -- 34. Role of Acyl-CoA Synthetases in Glioma Cell Survival and Its Therapeutic Implication -- 35. Malignant Glioma Patients: Combined Treatment with Radiation and Fotemustine -- 36. Malignant Glioma Immunotherapy: A Peptide Vaccine from Bench to Bedside -- 37. Malignant Glioma: Chemovirotherapy -- 38. Intracranial Glioma: Delivery of an Oncolytic Adenovirus -- 39. Use of Magnetic Resonance Spectroscopy Imaging (MRSI) in the Treatment Planning of Gliomas -- 40. Malignant Glioma Cells: Role of Trail-Induced Apoptosis -- Part V. Prognosis -- 41. Long-Term Survivors of Glioblastoma -- 42. Glioblastoma Patients: p15 Methylation as a Prognostic Factor.
- Format
- e-Book
- Location
- Online
Cancer rehabilitation and survivorship : transdisciplinary approaches to personalized care
https://libcat.nshealth.ca/en/permalink/provcat25512
Lester, Joanne L.
--Pittsburgh, PA:
Oncology Nursing Society
, 2011.
- Call Number
- QZ 200 L642c 2011
- Location
- Dickson Building
- Call Number
- QZ 200 L642c 2011
- Author
- Lester, Joanne L
- Other Authors
- Schmitt, Patricia
- Place of Publication
- Pittsburgh, PA
- Publisher
- Oncology Nursing Society
- Date of Publication
- 2011
- Physical Description
- 500 p.
- ISBN
- 9781935864059
- Subjects (MeSH)
- Neoplasms - rehabilitation
- Neoplasms
- Neoplasms - psychology
- Neoplasms - complications
- Survivors - psychology
- Format
- Book
- Location
- Dickson Building
- Copies
- 1
- Loan Period
- 3 weeks
Serous Effusions : Etiology, Diagnosis, Prognosis and Therapy
https://libcat.nshealth.ca/en/permalink/provcat30815
Ben Davidson, editor-in-chief ; Pinar Firat, Claire W. Michael, editors.
--London:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Serous (peritoneal, pleural and pericardial) effusions are a frequently encountered clinical finding in everyday medical practice and one of the most common specimen types submitted for cytological evaluation. The correct diagnosis of effusions is critical for patient management, as well as for prognostication and yet many clinicians find diagnosis and treatment of cancer cells in effusions very challenging. Featuring multiple microscopic illustrations of all diagnostic entities and ancillary …
- Available Online
- View e-Book
- Other Authors
- Davidson, Ben
- Firat, Pinar
- Michael, Claire W
- Responsibility
- Ben Davidson, editor-in-chief ; Pinar Firat, Claire W. Michael, editors
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xi, 258 p. : 248 ill., 238 ill. in color)
- ISBN
- 9780857296979
- 9780857296962 (print ed.)
- Subjects (MeSH)
- Ascitic Fluid - pathology
- Neoplasms - diagnosis
- Neoplasms - etiology
- Pericardial Effusion - diagnosis
- Pericardial Effusion - pathology
- Pleural Effusion - diagnosis
- Pleural Effusion - pathology
- Cytodiagnosis
- Abstract
- Serous (peritoneal, pleural and pericardial) effusions are a frequently encountered clinical finding in everyday medical practice and one of the most common specimen types submitted for cytological evaluation. The correct diagnosis of effusions is critical for patient management, as well as for prognostication and yet many clinicians find diagnosis and treatment of cancer cells in effusions very challenging. Featuring multiple microscopic illustrations of all diagnostic entities and ancillary techniques (immunhistochemistry and molecular methods), this book provides a comprehensive, authoritative guide to all aspects of serous effusions, including etiology, morphology and ancillary diagnostic methods, as well as data related to therapeutic approaches and prognostication. Section One covers diagnosis for benign and malignant effusions including the etiological reasons for the accumulation of effusions that provides the reader with the full spectrum of differential diagnoses at this anatomic site. Section Two discusses biology, therapy and prognosis highlighting clinical approaches that may be of value to patients and the movement towards personalized medicine and targeted therapy. Written by experts in the field internationally, Serous Effusions will provide an indispensible guide to all aspects of current practice for cytopathologists, cytotechnicians, pathologists, clinicians and researchers in training and practice.
- Contents
- Part I. Diagnosis -- Benign effusions -- Lung carcinoma -- Ovarian/primary peritoneal carcinoma -- Breast carcinoma -- Malignant mesothelioma -- Hematological hematologic and lymphoid neoplasia -- Cancer of other origin -- Part II. Biology, Therapy, and Prognosis -- Lung cancer -- Ovarian/primary peritoneal carcinoma -- Breast cancer -- Malignant mesothelioma -- Cancer of other origin.
- Format
- e-Book
- Location
- Online
Cancer Chemotherapy in Clinical Practice
https://libcat.nshealth.ca/en/permalink/provcat30817
Terry Priestman.
(2nd ed.)
--London:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
The last decade has seen many dramatic changes in cancer chemotherapy, with the introduction of a number of new forms of treatment as well as important developments in the more traditional fields of cytotoxic and hormonal therapy. Now in its second edition, this book summarizes the whole range of systemic cancer therapies and their clinical applications, taking into account new drugs and the emerging concept of personalized therapy. Intended as an introductory text for junior doctors, nurses a…
- Available Online
- View e-Book
- Author
- Priestman, Terrence
- Responsibility
- Terry Priestman
- Edition
- 2nd ed.
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xiii, 177 p. : 15 ill., 3 ill. in color)
- ISBN
- 9780857297273
- Subjects (MeSH)
- Neoplasms - drug therapy
- Antineoplastic Agents - therapeutic use
- Abstract
- The last decade has seen many dramatic changes in cancer chemotherapy, with the introduction of a number of new forms of treatment as well as important developments in the more traditional fields of cytotoxic and hormonal therapy. Now in its second edition, this book summarizes the whole range of systemic cancer therapies and their clinical applications, taking into account new drugs and the emerging concept of personalized therapy. Intended as an introductory text for junior doctors, nurses and medical students, Cancer Chemotherapy in Clinical Practice is divided into three sections: The Theoretical Basis of Cancer Chemotherapy: following a historical introduction the different treatment modalities are explained in the context of basic tumor biology Practical Aspects of Chemotherapy: covering dosing and drug delivery together with an extensive discussion of possible side-effects and their management Chemotherapy in the Management of Cancer: explaining the place of drug treatment and the outcomes that can be expected from chemotherapy in all the major cancers.
- Contents
- 1. The Theoretical Basis of Cancer Chemotherapy -- 2. Practical aspects of chemotherapy -- 3. Part III: Chemotherapy in the management of cancer
- Format
- e-Book
- Location
- Online
Functional Neuroradiology : Principles and Clinical Applications
https://libcat.nshealth.ca/en/permalink/provcat30838
Scott H. Faro, Feroze B. Mohamed, editors ; Meng Law, associate editor ; John L. Ulmer, diffusion tensor imaging section editor.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Functional Neuroradiology: Principles and Clinical Applications, is a follow-up to Faro and Mohamed's groundbreaking work, Functional (BOLD) MRI: Basic Principles and Clinical Applications. This new 49 chapter textbook is comprehensive and offers a complete introduction to the state-of-the-art functional imaging in Neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffus…
- Available Online
- View e-Book
- Other Authors
- Faro, Scott H
- Mohamed, Feroze B
- Law, Meng
- Ulmer, John T
- Responsibility
- Scott H. Faro, Feroze B. Mohamed, editors ; Meng Law, associate editor ; John L. Ulmer, diffusion tensor imaging section editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxi, 1029 p. : 897 ill., 476 ill. in color)
- ISBN
- 9781441903457
- Subjects (MeSH)
- Brain Diseases - diagnosis
- Image Processing, Computer-Assisted - methods
- Neuroimaging - methods
- Subjects (LCSH)
- Neurosciences
- Radiology, Medical
- Neurology
- Abstract
- Functional Neuroradiology: Principles and Clinical Applications, is a follow-up to Faro and Mohamed's groundbreaking work, Functional (BOLD) MRI: Basic Principles and Clinical Applications. This new 49 chapter textbook is comprehensive and offers a complete introduction to the state-of-the-art functional imaging in Neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 9 major sections, including: Physical principles of all key functional techniques; Lesion characterization using Diffusion, Perfusion, Permeability, MR spectroscopy, and Positron Emission Tomography; An overview of BOLD fMRI physical principles and key concepts, including scanning methodologies, experimental research design, data analysis, and functional connectivity; Eloquent Cortex and White matter localization using BOLD fMRI and Diffusion Tensor Imaging; Clinical applications of BOLD fMRI in Neurosurgery, Neurology, Psychiatry, Neuropsychology, and Neuropharmacology; Multi-modality functional Neuroradiology; Beyond Proton Imaging; Functional spine and CSF imaging; A full-color Neuroanatomical Brain atlas of eloquent cortex and key white matter tracts and BOLD fMRI paradigms. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.
- Contents
- Part I. Diffusion and Perfusion Imaging -- 1. Physical Principles of Diffusion Imaging -- 2. Clinical Applications of Diffusion -- 3. Physical Principles of MR Perfusion and Permeability Imaging: Gadolinium Bolus Technique -- 4. Non-gadolinium Perfusion Technique (Arterial Spin Labeling) -- 5. Clinical Applications of MR Perfusion Imaging -- 6. Stroke: Clinical Application of Perfusion and Diffusion -- 7. Clinical Applications of Dynamic Contrast-Enhanced (DCE) Permeability Imaging -- Part II. Magnetic Resonance Spectroscopy -- 8. Magnetic Resonance Spectroscopy: Physical Principles -- 9. Magnetic Resonance Spectroscopy: Clinical Applications -- Part III. Multi Modality Functional Neuroradiology -- 10. Functional Imaging-Based Diagnostic Strategy: Intra-axial Brain Masses -- 11. Functional Neuroimaging of Epilepsy -- 12. Functional Neuroradiology of Traumatic Brain Injury -- 13. Functional MRI of Multiple Sclerosis -- 14. Functional Neuroradiology of Psychiatric Diseases -- 15. Neuroimaging of Pain -- Part IV. BOLD Functional MRI: Physical Principles -- 16. Principles of BOLD Functional MRI -- 17. fMRI Scanning Methods -- 18. Experimental Design and Data Analysis for fMRI -- 19. Challenges in fMRI and Its Limitations -- 20. Neurovascular Uncoupling in Functional MR Imaging -- 21. Functional Connectivity MR Imaging -- 22. Clinical Challenges of Functional MRI -- Part V. BOLD Functional MRI: Clinical Applications -- 23 fMRI of Language Systems: Methods and Applications -- 24. Functional MRI Studies of Memory in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease -- 25. fMRI Wada Test: Prospects for Presurgical Mapping of Language and Memory -- 26. fMRI of Human Visual Pathways -- 27. Brain Mapping for Neurosurgery and Cognitive Neuroscience -- 28. Pediatric Applications of fMRI -- 29. fMRI of the Central Auditory System -- 30. fMRI of Epilepsy -- 31. Applications of fMRI to Psychiatry -- 32. Applications of fMRI to Neurodegenerative Disease -- 33. Applications of MRI to Psychopharmacology -- 34. Functional MRI: Cognitive Neuroscience Applications -- Part VI. Diffusion Tensor Imaging -- 35. Diffusion Tensor Magnetic Resonance Imaging: Physical Principles -- 36. Issues in Translating Imaging Technology and Presurgical Diffusion Tensor Imaging -- 37. White Matter: Functional Anatomy of Key Tracts -- 38. Epilepsy: Clinical Applications of Diffusion Tensor Imaging -- 39. DTI and fMRI: Review of Complementary Techniques -- Part VII. Beyond Proton Imaging -- 40. Magnetoencephalography: Epilepsy and Brain Mapping -- 41. PET-CT/MR Imaging in Head and Neck Cancer: Physiologic Variations, Pitfalls, and Directed Applications -- 42. Simultaneous PET and MR Imaging of the Human Brain -- 43. The Role of Molecular Imaging in Personalized Medicine -- 44. Metabolic Magnetic Resonance Imaging: A Case for Bioscales in Medicine -- Part VIII. Functional Spine and CSF Imaging -- 45. Functional MRI of the Spinal Cord: Diffusion-Weighted, Diffusion Tensor Imaging, and Fiber Tractography -- 46. MRI of Hydrocephalus and CSF Velocity Imaging -- Part IX. Neuroanatomical Brain Atlas -- 47. Neuroanatomical Atlas of Key Presurgical and Cognitive Eloquent Cortex Regions -- 48. Normal Anatomic Atlas of Common White Matter Tracts Using DTI -- 49. fMRI Paradigms -- Index.
- Format
- e-Book
- Location
- Online
A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities
https://libcat.nshealth.ca/en/permalink/provcat30950
Jose de Leon, editor.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Emotional, behavioral, and neuropsychiatric conditions are common in individuals with intellectual disabilities (IDs), most notably epilepsy, aggression, self-injurious behaviors, and bipolar and other mood disorders. Despite the prevalence of such problems, there is a scarcity in the literature of reliable information on medical treatments for those with IDs. A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities provides a detailed…
- Available Online
- View e-Book
- Author
- de Leon, Jose
- Responsibility
- Jose de Leon, editor
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxxi, 507 p.)
- ISBN
- 9781461420125
- Subjects (MeSH)
- Adult
- Anticonvulsants - administration & dosage
- Anticonvulsants - therapeutic use
- Mentally Disabled Persons - psychology
- Tranquilizing Agents - administration & dosage
- Tranquilizing Agents - therapeutic use
- Subjects (LCSH)
- Neurology
- Psychiatry
- Psychopharmacology
- Psychology, clinical
- Abstract
- Emotional, behavioral, and neuropsychiatric conditions are common in individuals with intellectual disabilities (IDs), most notably epilepsy, aggression, self-injurious behaviors, and bipolar and other mood disorders. Despite the prevalence of such problems, there is a scarcity in the literature of reliable information on medical treatments for those with IDs. A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities provides a detailed framework for prescribing for this challenging population. Featuring the most up-to-date information on factors that inform prescribing, the Guide addresses basic issues and controversies (e.g., the rift between evidence-based and personalized medicine) in treating adults with cognitive deficits. Clients' specific needs are emphasized in developing appropriate and effective pharmacological intervention for improved outcomes and quality of life. Drugs discussed in the Guide include carbamazepine, clonazepam, diazepam, ethosuximide, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, lithium, lorazepam, oxcarbazepine, phenobarbital, phenytoin, pregabalin, primidone, rufinamide, átiagabine, topiramate, valproate, and zonisamide. For each of these compounds, the guidelines cover: Indications for use; Relative and absolute contraindications; Assessment during treatment; Therapeutic drug monitoring; Warning signs and symptoms for caretakers; Dosage: administration, initial and maximum recommended dosage; Modifications associated with drug-drug interactions, personal characteristics, and (where appropriate) genetic variations; Adverse drug reactions: common, relatively uncommon, and potentially lethal, plus risk of metabolic syndrome. Guidelines for discontinuation. References, tables, and drug utilization reviews. A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities is an indispensable decision-making reference for psychiatrists, neuropsychologists, psychopharmacologists, neurologists, internists, and clinical psychologists.
- Contents
- 1. Introduction -- 2. A Practitioner's Guide to Prescribing Carbamazepine for Adults with Intellectual Disabilities -- 3. A Practitioner's Guide to Prescribing Clonazepam for Adults with Intellectual Disabilities -- 4. A Practitioner's Guide to Prescribing Diazepam for Adults with Intellectual Disabilities -- 5. A Practitioner's Guide to Prescribing Ethosuximide for Adults with Intellectual Disabilities -- 6. A Practitioner's Guide to Prescribing Felbamate for Adults with Intellectual Disabilities -- 7. A Practitioner's Guide to Prescribing Gabapentin for Adults with Intellectual Disabilities -- 8. A Practitioner's Guide to Prescribing Lacosamide for Adults with Intellectual Disabilities -- 9. A Practitioner's Guide to Prescribing Lamotrigine For Adults with Intellectual Disabilities -- 10. A Practitioner's Guide to Prescribing Levetiracetam for Adults with Intellectual Disabilities -- 11. A Practitioner's Guide to Prescribing Lithium for Adults with Intellectual Disabilities -- 12. A Practitioner's Guide to Prescribing Lorazepam for Adults with Intellectual Disabilities -- 13. A Practitioner's Guide to Prescribing Oxacarbazepine for Adults with Intellectual Disabilities -- 14. A Practitioner's Guide to Prescribing Phenobarbital for Adults with Intellectual Disabilities -- 15. A Practitioner's Guide to Prescribing Phenytoin for Adults with Intellectual Disabilities -- 16. A Practitioner's Guide to Prescribing Pregabalin for Adults with Intellectual Disabilities -- 17. A Practitioner's Guide to Prescribing Primidone for Adults with Intellectual Disabilities -- 18. A Practitioner's Guide to Prescribing Rufinamide for Adults with Intellectual Disabilities -- 19. A Practitioner's Guide to Prescribing Tiagabine for Adults with Intellectual Disabilities -- 20. A Practitioner's Guide to Prescribing Topiramate for Adults with Intellectual Disabilities -- 21. A Practitioner's Guide to Prescribing Valproate for Adults with Intellectual Disabilities -- 22. A Practitioner's Guide to Prescribing Zonisamide for Adults with Intellectual Disabilities -- 23. A Practitioner's Guide to Prescribing Non-oral Antiepileptics for Adults with Intellectual Disabilities -- 24. Conclusion.
- Format
- e-Book
- Location
- Online
Molecular Pathology of Lung Cancer
https://libcat.nshealth.ca/en/permalink/provcat30969
Philip T. Cagle ... [et al.], editors.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, …
- Available Online
- View e-Book
- Other Authors
- Cagle, Philip T
- Responsibility
- Philip T. Cagle ... [et al.], editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xi, 216 p. : 46 ill. in color)
- Series Vol.
- v. 6
- Series Title
- Molecular pathology library
- ISBN
- 9781461431978
- Subjects (MeSH)
- Lung Neoplasms - pathology
- Molecular Diagnostic Techniques
- Molecular Targeted Therapy
- Pathology, Molecular - methods
- Subjects (LCSH)
- Oncology
- Pathology
- Thoracic surgery
- Abstract
- As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
- Contents
- Part I. Molecular Pathology of Lung Cancer: General Principles -- Approach to Personalized Care of the Lung Cancer Patient -- Etiology of Lung Cancer -- Genetic Susceptibility to Lung Cancer -- Lung Cancer Stem Cells -- The Classification of Pre-Invasive Lesions -- Molecular Pathology of Precursor and Pre-Invasive Lesions -- Revised Classification for Adenocarcinoma -- Molecular Basis for the Current Lung Cancer Classification -- Molecular Diagnosis of Lung Cancer -- Molecular Targeted Therapy of Lung Cancer -- Molecular Prognostic Markers of Lung Cancer -- New Techniques for Optical and Molecular Visualization of Lung Cancer -- Part II. Molecular Pathology of Lung Cancer: Specific Histologic Types -- Adenocarcinoma -- Squamous Cell Carcinoma -- Molecular Pathology of Large Cell Carcinoma -- Molecular Pathology of Small Cell Carcinomas -- Molecular Biopsy of Neuroendocrine Carcinomas Other Than Small Cell Carcinoma -- Molecular Pathology of Uncommon Carcinomas -- Biology of Lung Cancer Metastases.
- Format
- e-Book
- Location
- Online
Psychodynamic Psychotherapy Research : Evidence-Based Practice and Practice-Based Evidence
https://libcat.nshealth.ca/en/permalink/provcat31006
Raymond A. Levy, J. Stuart Ablon, Horst Kächele, editors.
--New York, NY:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence continues the important work of the first book published in 2009 by Humana Press (Handbook of Evidence-Based Psychodynamic Psychotherapy: Bridging the Gap Between Science and Practice). This landmark title presents in one volume significant developments in research, including neuroscience research, in psychodynamic psychotherapy by a team of renowned clinician-researchers. The demand for ongoing research i…
- Available Online
- View e-Book
- Other Authors
- Levy, Raymond A
- Ablon, J. Stuart
- Kächele, Horst
- Responsibility
- Raymond A. Levy, J. Stuart Ablon, Horst Kächele, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxxiii, 646 p. : 51 ill., 18 ill. in color)
- Series Title
- Current clinical psychiatry
- ISBN
- 9781607617921
- Subjects (LCSH)
- Neurology
- Psychiatry
- Psychotherapy
- Abstract
- Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence continues the important work of the first book published in 2009 by Humana Press (Handbook of Evidence-Based Psychodynamic Psychotherapy: Bridging the Gap Between Science and Practice). This landmark title presents in one volume significant developments in research, including neuroscience research, in psychodynamic psychotherapy by a team of renowned clinician-researchers. The demand for ongoing research initiatives in psychodynamic psychotherapy from both internal and external sources has increased markedly in recent years, and this volume continues to demonstrate the efficacy and effectiveness of a psychodynamic approach to psychotherapeutic interventions in the treatment of psychological problems. The work in this volume is presented in the spirit of ongoing discussion between researchers and clinicians about the value of specific approaches to specific patients with specific psychiatric and psychological problems. Multiple forms of treatment interventions have been developed over the past fifty years, and this volume makes clear, with firm evidence, the authors' support for the current emphasis on personalized medicine. Groundbreaking and a major contribution to the psychiatric and psychologic literature, Psychodynamic Psychotherapy Research: Evidence-Based Practice and Practice-Based Evidence provides firm grounding for advancing psychodynamic psychotherapy as a treatment paradigm.
- Contents
- Part I. Outcome Research -- Commentary: Research on Short- and Long-Term Psychoanalytic Treatment – The Current State of the Art -- The Efficacy of Psychodynamic Psychotherapy -- Effectiveness of Long-Term Psychodynamic Psychotherapy: First Meta-Analytic Evidence and Its Discussion -- Must All Have Prizes? The Munich Psychotherapy Study -- The Helsinki Psychotherapy Study: Effectiveness, Sufficiency, and Suitability of Short- and Long-Term Psychotherapy -- Psychoanalytic and Psychodynamic Therapies for Depression: The Evidence Base -- Evidence-Based Psychodynamic Treatments for Anxiety Disorders: A Review -- An Update and Overview of the Empirical Evidence for Transference Focused Psychotherapy and Other Psychotherapies for Borderline Personality Disorder -- What Happens After Treatment: Can Structural Change be a Predictor of Long-Term Outcome? -- Part II. The Neurobiology of Psychotherapy -- Commentary: Neurobiology of Psychotherapy – State of the Art and Future Directions -- Neural Models of Psychodynamic Concepts and Treatments: Implications for Psychodynamic Psychotherapy -- Toward Molecular Psychotherapy of Depression? -- Psychotherapy Increases the Amount of Serotonin Receptors in the Brains of Patients with Major Depressive Disorder -- Neural Correlates of Emotion, Cognition, and Attachment in Borderline Personality Disorders and its Clinical Implications -- Neurobiologically Informed Psychotherapy of Borderline Personality Disorder -- Foundations of Psychodynamic Therapy: Implicit Emotional Learning -- Neurobiological Correlates of the Psychotherapy Relationship and E.M.P.A.T.H.Y.: The Role of Biomarkers in Psychotherapy -- Bridging Technology and Psychotherapy: Towards Investigating Psychological and Neural Correlates of Psychodynamic Psychotherapy -- The Neurobiological Foundations of Psychotherapy -- Part III. Theory, Technique, and Process -- Commentary: The Coming of Age of Psychoanalytic Treatment Research -- Process and Outcome in Psychoanalytic Psychotherapy Research: The Need for a (Relatively) New Paradigm -- How to Make Practical Use of Therapeutic Alliance Research in Your Clinical Work -- The Contributions of the Psychotherapy Process Q-set to Psychotherapy Research -- Attachment Theory and Research: Implications for Psychodynamic Psychotherapy -- Accuracy of Defense Interpretation in Three Character Types -- When is Transference Work Useful in Psychodynamic Psychotherapy? A Review of Empirical Research -- Part IV. Single Case Studies -- Single Case Research: The German Specimen Case Amalia X -- Combining Idiographic and Nomothetic Approaches to Single Case Research -- A Session of Psychoanalysis as Analyzed by the Psychotherapy Process Q-set: Amalia X, Session 152 -- Part V. Assessing Change -- Ten Diverse Outcome Measures for Psychodynamic Psychotherapy Research -- Empirically Informed Clinical Interviewing for Personality Disorders -- The Structured Interview of Personality Organization (STIPO): An Instrument to Assess Severity and Change of Personality Pathology -- Appendices -- Appendix IA. Psychotherapy Process Q-Set Coding Manual (Adult) -- Appendix IB. Child Psychotherapy Q-Set Coding Manual -- Appendix IIA. Introduction to Manualized Treatments for Psychodynamic Psychotherapy Research -- Appendix IIB. Listing of Psychodynamic Manualized Treatments.
- Format
- e-Book
- Location
- Online
Molecular Genetics and Personalized Medicine
https://libcat.nshealth.ca/en/permalink/provcat31012
D. Hunter Best, Jeffrey J. Swensen, editors.
--New York, NY:
Humana Press
, c2012.
- Available Online
- View e-Book
- Location
- Online
Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual's specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also…
- Available Online
- View e-Book
- Other Authors
- Best, D. Hunter
- Swensen, Jeffrey J
- Responsibility
- D. Hunter Best, Jeffrey J. Swensen, editors
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (x, 243 p. : 39 ill., 29 ill. in color)
- Series Title
- Molecular and translational medicine
- ISBN
- 9781617795305
- Subjects (MeSH)
- Genetic techniques
- Genetic testing
- Individualized Medicine
- Abstract
- Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual's specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also prove to be an invaluable resource for the basic scientist that wants to better understand how advances in the laboratory are being moved from the bench to the bedside. All chapters are written by experts in their fields and include the most up to date medical information. The authors simplify complex genetic concepts and focus on practical patient related issues. The book will be of great value to pathologists, hematologists/oncologists, clinical geneticists, high-risk obstetricians, general practitioners, and physicians in all other medical specialties who utilize genetic testing to direct therapy.
- Contents
- Molecular Genetic Testing in the Genomic Era -- Array Comparative Genomic Hybridization in Cytogenetics and Molecular Genetics -- Pharmacogenomics: Tailoring Treatment Based on Genotype -- Somatic Alterations and Targeted Therapy -- Genome-Wide Association Studies in Disease Risk Calculation: The Role of Bioinformatics in Patient Care -- Presymptomatic Genetic Testing: Shifting the Emphasis from Reaction to Prevention -- Prenatal Testing: Screening, Diagnosis and Preimplantation Genetic Diagnosis -- Newborn Screening for Metabolic Disorders -- The Role of Genetic Counseling in Everyday Medical Practice -- Direct-to-Consumer Genetic Testing.
- Format
- e-Book
- Location
- Online
Pediatric Neoplasia : Advances in Molecular Pathology and Translational Medicine
https://libcat.nshealth.ca/en/permalink/provcat31030
Alexander Craig Mackinnon, Jr., editor.
--New York, NY:
Humana Press
, c2012.
- Available Online
- View e-Book
- Location
- Online
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts …
- Available Online
- View e-Book
- Other Authors
- Mackinnon, Alexander Craig
- Responsibility
- Alexander Craig Mackinnon, Jr., editor
- Place of Publication
- New York, NY
- Publisher
- Humana Press
- Date of Publication
- c2012
- Physical Description
- 1 online resource (ix, 267 p. : 76 ill., 73 ill. in color)
- Series Title
- Molecular and translational medicine
- ISBN
- 9781627031165
- Subjects (MeSH)
- Neoplasms - pathology
- Pathology, Molecular - methods
- Pediatrics
- Translational Medical Research - methods
- Subjects (LCSH)
- Oncology
- Pathology
- Pediatrics
- Abstract
- Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
- Contents
- 1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy -- 2. Acute Leukemia -- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia -- 4. Myelodysplasia and Myeloid Proliferations -- 5. Childhood Lymphoma -- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors -- 7. Pediatric Bone Tumors -- 8. Soft Tissue "Small Round Blue Cell Tumors" of Childhood -- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors -- 10. Molecular Analysis in Pediatric Renal Tumors -- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.
- Format
- e-Book
- Location
- Online
Healthcare Overview : New Perspectives
https://libcat.nshealth.ca/en/permalink/provcat31283
Vincenzo Costigliola, editor.
--Dordrecht:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
Just a few years ago, dire predictions of escalating technology costs and adverse demographics informed a downbeat view of the future of medicine in which struggling governments would fall behind in their public commitments to healthcare. This volume is part of today's more optimistic assessment in which huge efficiencies can be wrought through 'personalized' medicine: patients, for example, have no need to visit clinics when biochemical monitoring can be achieved in the comfort of their own ho…
- Available Online
- View e-Book
- Other Authors
- Costigliola, Vincenzo
- Responsibility
- Vincenzo Costigliola, editor
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xviii, 521 p. : 86 ill., 73 ill. in color)
- Series Vol.
- v. 1
- ISBN
- 9789400746022
- Subjects (MeSH)
- Individualized Medicine - trends
- Global Health - trends
- Subjects (LCSH)
- Public health
- Abstract
- Just a few years ago, dire predictions of escalating technology costs and adverse demographics informed a downbeat view of the future of medicine in which struggling governments would fall behind in their public commitments to healthcare. This volume is part of today's more optimistic assessment in which huge efficiencies can be wrought through 'personalized' medicine: patients, for example, have no need to visit clinics when biochemical monitoring can be achieved in the comfort of their own homes, the results sent wirelessly, in real time, to the specialist's database. With contributions spanning the experiences of 15 nations from the USA to Turkey, Taiwan and the UK, the contents of this book show what is possible in implementing personalized medicine in a heterogeneous set of contexts. Today's burgeoning use of advanced early and predictive diagnostics, targeted prevention and personalized medical approaches will accelerate as advances in patient profiling and innovative bio/medical technologies come on stream. They could enable many of tomorrow's elderly to reach 100 years of age in good physical and mental health, as actively contributing members of society. The scope of coverage in this volume provides a comprehensive and unrivaled review of historical, cultural, demographic, ethnic, socio-economic, political, and other aspects of personalized medicine. It shows that reaping the benefits of this kind of medical care requires careful regulations in healthcare and skilful political planning.
- Contents
- [Machine generated contents note] Global Process of Personalisation in Medicine: New Perspectives in Healthcare / Vincenzo Costigliola -- Pt. I. Healthcare Systems Around the Globe -- Italian Healthcare System in the Global Context: The Cultural Challenge of Predictive, Preventive and Personalized Medicine / Francesco Basile -- Healthcare in the UK - Predictive, Preventive and Personalised Medicine Perspective at the Beginning of the Twenty-First Century / Jane Burbidge -- German Healthcare System / Friedemann Paul -- Healthcare Overview in the Slovak Republic and Implementation of Predictive, Preventive and Personalized Medicine / Ladislav Turecky -- Overview of the Healthcare System in the Czech Republic with Respect to Predictive, Preventive and Personalized Medicine / Ondrej Topolcan -- Perpetual Transitions in Romanian Healthcare / Mircea Marzan -- Overview of the Healthcare System in Georgia / Tamari Rukhadze -- Genera] Overview of the Healthcare System in the Republic of Macedonia: Health Indicators, Organization of Healthcare System and Its Challenges / Kneginja Richter -- Overview of the Healthcare System in Turkey / Sevda Yesim Ozdemir -- Taiwan’s Healthcare Report / Willie Sai Ho Chan -- Mobility of Medical Doctors as an Attribute of the Cross-Border Healthcare: Challenges, Opportunities and Perspectives / Vincenzo Costigliola -- Where Is the European Pharma Industry Going? / Michele Antonelli -- Pt. II. Female Health/Care -- Changing Long-Held Beliefs Is Never Easy: A Proposal for Multimodal Approaches in Female Healthcare - An Integrative View / Olga Golubnitschaja -- Gender-Specific Nutritional Approach to Women’s Healthcare / Niva Shapira -- Implications of Gender Based Biology in Oral Health Issues - Are Women More Susceptible? / Connie Drisko -- Simultaneous Systematic Approach to Enable Predictive, Preventive and Personalized Medicine - Women Healthcare as a Case Study / Hamutal Meiri -- Pt. III. Traditional and Non-Conventional Medicine -- Widening the Paradigm in Medicine and Health: Person-Centred Medicine as the Common Ground of Traditional, Complementary, Alternative and Non-Conventional Medicine / Paola Guadagni -- Music Therapy, a Personalised Bridge Towards Healing Beyond Surgery and Medication: European Paediatrics Overview / Reiner Haus -- Pt. IV. Role of Laboratory Medicine in Healthcare -- Characterization and Validation of Biomarkers by Immunoassays: Quality Requirements, Physical Standards and Data Management in Predictive Medicine / Kurt Krapfenbauer -- Pt. V. Economy of PPPM -- Effectiveness, Cost Effectiveness, and Financial Viability of Personalized Medicine: A Role for Comparative Effectiveness Research? / Paul M. Brown -- Economic Challenge of Predictive, Preventive and Personalized Medicine: The Case Study of Lung, Head and Neck Cancer / Kurt Krapfenbauer -- Health Promotion and Prevention in Companies - Economic Aspects and Prevention Strategies for Shift Work Sleep Disorders / Guenter Niklewski -- Pt. VI. Ethics of PPPM -- New Ethical Paradigm in Preventive, Predictive and Personalised Medicine / Dainius Characiejus.
- Format
- e-Book
- Location
- Online
Tumors of the Central Nervous System. Volume 5, Astrocytomas, Hemangioblastomas, and Gangliogliomas
https://libcat.nshealth.ca/en/permalink/provcat40879
edited by M.A. Hayat.
--Dordrecht:
Springer
, c2012.
- Available Online
- View e-Book
- Location
- Online
The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. áThe importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The …
- Available Online
- View e-Book
- Other Authors
- Hayat, M.A
- Responsibility
- edited by M.A. Hayat
- Alternate Title
- Astrocytomas, hemangioblastomas, and gangliogliomas
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2012
- Physical Description
- 1 online resource (xxv, 290 p. : ill.)
- Series Vol.
- v. 5
- Series Title
- Tumors of the central nervous system
- ISBN
- 9789400720190
- 9789400720183 (print ed.)
- Subjects (MeSH)
- Astrocytoma
- Central Nervous System Neoplasms
- Ganglioglioma
- Hemangioblastoma
- Abstract
- The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. áThe importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.
- Contents
- Part I. Astrocytomas: Diagnosis and Biomarkers -- 1. Methylation in Malignant Astrocytomas -- 2. Deciphering the Function of Doppel Protein in Astrocytomas -- 3. Astrocytic Tumors: Role of Antiapoptotic Proteins -- 4. Deregulation of the Wnt/ß-Catenin/Tcf Signaling Pathway in Astrocytomas -- 5. Subependymal Giant Cell Astrocytoma: Role of mTOR Pathway and Its Inhibitors -- 6. Role of Progesterone Receptor Isoforms in Human Astrocytomas Growth -- 7. Astrocytic Tumors: Role of Carbonic Anhydrase IX -- 8. Development of Cysts in Pilocytic Astrocytomas: Role of Eosinophilic Granular Bodies (Method) -- 9. Role of Synemin in Astrocytoma Cell Migration -- 10. Diffuse Astrocytomas: Immunohistochemistry of MGMT Expression -- 11. Central Nervous System Germ Cell Tumors: An Epidemiology Review -- 12. RAF Fusion Genes and MAPK Activation in Pilocytic Astrocytomas -- 13. Biomarker Discovery in Central Nervous System Neoplasms: Past, Present and Future -- 14. Astrocytomas: Role of Taurine in Apoptosis Using Magnetic Resonance Spectroscopy -- 15. Imaging of Hypoxia-Inducible Factor-1-Active Regions in Tumors Using a POS and 123I-IBB Method -- 16. Diffuse Low-Grade Astrocytomas: P53-Mediated Inhibition of Angiogenesis -- 17. Spontaneous Regression of Cerebellar Astrocytomas -- 18. Subependymal Giant Cell Astrocytoma: Gene Expression Profiling -- Part II. Astrocytomas: Therapy -- 19. Time-Resolved Laser Induced Fluorescence Spectroscopy (TRLIFS): A Tool for Intra-operative Diagnosis of Brain Tumors and Maximizing Extent of Surgical Resection -- 20. Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Tumors -- 21. Nanotechnology-Based Therapy for Malignant Tumors of the Central Nervous System -- 22. Pilocytic Astrocytoma: Pathological and Immunohistochemical Factors Affecting Surgical Treatment and Surveillance -- 23. Pilomyxoid Astrocytomas: Chemotherapy -- Part III. Astrocytomas: Prognosis -- 24. Astrocytomas: Predicting Survival and Recurrence Using Cerebral Blood Volume Measurements -- 25. Electronic Patient-Reported Outcome Monitoring (ePROM) in Brain Tumour Patients -- Part IV. Hemangioblastoma -- 26. Intra-operative ICG Use in the Management of Hemangioblastomas -- 27. Hemangioblastoma Cysts: Diagnosis Using Fluorescence with 5-Aminolevulinic Acid -- 28. Hemangioblastoma: Stereotactic Radiosurgery -- Part V. Ganglioglioma -- 29. Gangliogliomas: Molecular Pathogenesis and Epileptogenesis -- 30. Epilepsy-Associated Gangliogliomas: Identification of Genes with Altered Expression.
- Format
- e-Book
- Location
- Online
Molecular surgical pathology
https://libcat.nshealth.ca/en/permalink/provcat32408
Liang Cheng, John N. Eble, editors.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a "first knowledge base" in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge…
- Available Online
- View e-Book
- Other Authors
- Cheng, Liang
- Eble, John N
- Responsibility
- Liang Cheng, John N. Eble, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xi, 436 p. : 131 ill., 125 ill. in color)
- ISBN
- 9781461449003
- Subjects (MeSH)
- Neoplasms - pathology
- Pathology, Molecular
- Pathology, Surgical
- Subjects (LCSH)
- Oncology
- Medical laboratories
- Pathology
- Abstract
- Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a "first knowledge base" in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.
- Contents
- Molecular Pathology of Colorectal Cancer -- Molecular Pathology of Pancreatic Cancer -- Molecular Pathology of Liver Tumors -- Molecular Pathology of Gallbladder Cancer -- Molecular Pathology of Lung Cancers -- Molecular Pathology of Breast Cancer -- Molecular Pathology of Ovarian Cancer -- Molecular Pathology of Endometrial Cancer -- Molecular Pathology of Kidney Tumors -- Molecular Pathology of Prostate Cancer -- Molecular Pathology of Urinary Bladder Cancer -- Molecular Pathology of Testicular Cancer -- Molecular Pathology of Cutaneous Melanoma and Nonmelanoma Skin Cancer -- Molecular Pathology of Head and Neck Cancer -- Molecular Pathology of Soft Tissue and Bone Tumors -- Molecular Pathology of the Central Nervous System -- Molecular Pathology of Endocrine Cancers -- Index.
- Format
- e-Book
- Location
- Online
Interventions in pulmonary medicine
https://libcat.nshealth.ca/en/permalink/provcat32438
Jose Pablo Díaz-Jimenez, Alicia N. Rodriguez, editors.
--New York, NY:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
Interventions in Pulmonary Medicine is an important new volume that addresses all areas of interventional pulmonology, a minimally invasive endoscopic way to diagnose and treat lung disorders. This volume contains dedicated chapters that outline the many issues related to lung cancer, both in early and advanced stages, from diagnosis to personalized treatment. It also covers bronchoscopic therapeutic options to benign conditions that are highly prevalent, such as COPD and asthma. Techniques de…
- Available Online
- View e-Book
- Other Authors
- Díaz-Jimenez, Jose Pablo
- Rodriguez, Alicia N
- Responsibility
- Jose Pablo Díaz-Jimenez, Alicia N. Rodriguez, editors
- Place of Publication
- New York, NY
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xviii, 494 p. : 210 ill., 189 ill. in color)
- ISBN
- 9781461460091
- Subjects (MeSH)
- Pulmonary Surgical Procedures
- Respiratory Tract Diseases - diagnosis
- Respiratory Tract Diseases - therapy
- Subjects (LCSH)
- Radiology, Medical
- Critical care medicine
- Pneumology
- Oncology
- Surgery
- Abstract
- Interventions in Pulmonary Medicine is an important new volume that addresses all areas of interventional pulmonology, a minimally invasive endoscopic way to diagnose and treat lung disorders. This volume contains dedicated chapters that outline the many issues related to lung cancer, both in early and advanced stages, from diagnosis to personalized treatment. It also covers bronchoscopic therapeutic options to benign conditions that are highly prevalent, such as COPD and asthma. Techniques described in this volume are: laser therapy, argon plasma coagulation therapy, cryotherapy, brachytherapy, placement of intrapleural drainage systems, endoscopic treatment of emphysema, stents in the airway, and thermoplasty for bronchial asthma.Diagnostic procedures that are covered are: medical thoracoscopy, flexible and rigid bronchoscopy, endobronchial ultrasound, electromagnetical navigation, and trends in personalized treatment for lung cancer and other benign lung conditions. Chapters are written by experts and the developers of the techniques that are currently considered gold standard.Evidence-based reviews are presented for all topics and indications, and contraindications are discussed.Interventions in Pulmonary Medicine is a must have for pulmonologists, endoscopists, pulmonary oncologists, ENT physicians, thoracic surgeons, anesthesiologists, and intensive care specialists and their teams.
- Contents
- Foreword -- Section I. Basic endoscopy -- 1. Tracheobronchial Anatomy -- 2. Flexible Bronchoscopy -- 3. Rigid Bronchoscopy -- 4. Anesthesia for Interventional Bronchoscopic Procedures -- 5. Evaluating Outcomes After Interventional Procedures -- 6. Bronchoscopy Education: New Insights -- Section II. Tracheobronchial obstructions -- 7. Reopening The Airway: Fast Methods Laser Assisted Mechanical Resection, Electrocautery and Argon Plasma Coagulation -- 8. Cryotherapy -- 9. Endobronchial Brachytherapy: Concept, Indications, Technique and Outcomes -- 10. Photodynamic Therapy for Early and Advanced Lung Cancer -- 11. Benign Tracheal And Bronchial Stenosis -- 12. Endobronchial Prosthesis -- Section III. Lung cancer diagnosis -- 13. Early Lung Cancer: Methods For Detection -- 14. Diagnostic Of Lung Cancer: Confocal Bronchoscopy -- 15. Optical Coherence Tomography -- 16. Electromagnetic Navigation -- 17. Lung Cancer Screening and the National Lung Screening Trial (NLST) -- 18. Tissue Acquisition In Patients With Suspected Lung Cancer: Techniques Available to the Pulmonologist -- Section IV. Lung cancer staging -- 19. The New Lung Cancer TNM Classification: Review And Clinical Implications -- 20. Mediastinoscopy And Its Variants -- 21. Endobronchial Ultrasound: Basic Principles -- 22. Endobronchial Ultrasound: Clinical Applications -- Section V. Pleural conditions -- 23. Pleural Anatomy -- 24. Medical Thoracoscopy -- 25. Overview of the Spectrum of Chest Tubes with Focus on the Tunneled Pleural Catheter: Disease Specific Selection -- Section VI. Interventional Bronchoscopy In Asthma And Emphysema -- 26. Endoscopic Methods For Lung Volume Reduction -- 27. Transbroncoscopic Emphysema Treatment with One-way Zephyr Valves -- 28. Endoscopic Lung Volume Reduction for Treatment of Advanced Emphysema Using Injectable Hydrogels -- 29. Bronchial Thermoplasty -- Section VII. Interventional Bronchoscopy In Special Situations -- 30. Percutaneous Tracheostomy -- 31. Bronchoscopy Role In Interstitial Lung Disease -- 32. Endoscopic Foreign Body Removal -- 33. Interventional Pulmonology in the Intensive Care Unit -- Section VIII. Conclusions -- 34. Bronchoscopy and Interventional Pulmonology: Reflections on the Past, the Present, and the Future.
- Format
- e-Book
- Location
- Online
Theranostics, Gallium-68, and Other Radionuclides : A Pathway to Personalized Diagnosis and Treatment
https://libcat.nshealth.ca/en/permalink/provcat32494
Richard P. Baum, Frank Rösch, editors.
--Berlin, Heidelberg:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics: the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and tr…
- Available Online
- View e-Book
- Other Authors
- Baum, Richard P
- Rösch, Frank
- Responsibility
- Richard P. Baum, Frank Rösch, editors
- Place of Publication
- Berlin, Heidelberg
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xviii, 576 p. : 180 ill., 122 ill. in color)
- Series Vol.
- 194
- Series Title
- Recent results in cancer research
- ISBN
- 9783642279942
- Subjects (MeSH)
- Gallium Radioisotopes - diagnostic use
- Neoplasms - diagnosis
- Neoplasms - therapy
- Positron-Emission Tomography Computed Tomography
- Radionuclide Imaging
- Radiopharmaceuticals
- Subjects (LCSH)
- Radiology, Medical
- Nuclear medicine
- Radiotherapy
- Oncology
- Abstract
- This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics: the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry,ámolecular imaging, and radionuclide therapy.
- Format
- e-Book
- Location
- Online
Diffuse low-grade gliomas in adults : natural history, interaction with the brain, and new individualized therapeutic strategies
https://libcat.nshealth.ca/en/permalink/provcat32544
Hugues Duffau, editor.
--London:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The biology, behavior and management of diffuse low-grade gliomas (DLGG) in adults have been matters of controversy for many decades. However, recent technical and conceptual advances in genetics, imaging and treatments have paved the way towards individualized management. In addition, advancing knowledge of brain processing means that it is possible to take into consideration the interaction between the disease (low-grade glioma) and the host (the brain) and thus to modulate the therapeutic st…
- Available Online
- View e-Book
- Other Authors
- Duffau, Hugues
- Responsibility
- Hugues Duffau, editor
- Place of Publication
- London
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xvii, 502 p. : 73 ill., 53 ill. in color)
- ISBN
- 9781447122135
- Subjects (MeSH)
- Glioma
- Subjects (LCSH)
- Medicine
- Radiology, Medical
- Neurology
- Oncology
- Abstract
- The biology, behavior and management of diffuse low-grade gliomas (DLGG) in adults have been matters of controversy for many decades. However, recent technical and conceptual advances in genetics, imaging and treatments have paved the way towards individualized management. In addition, advancing knowledge of brain processing means that it is possible to take into consideration the interaction between the disease (low-grade glioma) and the host (the brain) and thus to modulate the therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life. Diffuse Low-Grade Gliomas in Adults: Natural History, Interaction with the Brain, and New Individualized Therapeutic Strategies presents the latest research pertaining to the diagnosis, therapy and management of diffuse low-grade gliomas (DLGG) in adults, with a particular focus on the path towards individualized therapy for this kind of tumor. Recent research on the natural history of DLGGs and their interaction with the brain has led to new diagnostic and therapeutic strategies which increase survival and quality of life of the patient, and these methods are described in this book. This book uniquely focuses on addressing diffuse low-grade gliomas in adults and is a valuable resource for medical oncologists, neuro-oncologists and neurologists.
- Contents
- 1. Introduction: From the Inhibition of Dogmas to the Concept of Personalized Management in Diffuse Low-Grade Gliomas -- 2. Epidemiology of Diffuse Low-Grade Gliomas -- 3. Histological Classification -- 4. Is Gliomatosis Cerebri a Diffuse Low-Grade Glioma? -- 5. Contribution of Molecular Biology to the classification of Low-Grade Diffuse Gliomas -- 6. Cellular origin of Grade II Gliomas -- 7. Deciphering the Molecular and Cellular Basis for Dissemination of Diffuse Low-Grade Gliomas -- 8. The molecular biology of Diffuse Low-Grade Gliomas -- 9. Proteomic Studies in Low-Grade Gliomas: What They Have Informed About Pathophysiology? -- 10. Human Low-Grade Glioma Cultures -- 11. Animal Models for Low-Grade Gliomas -- 12. Clinical Presentation in Diffuse Low-Grade Gliomas -- 13. Epilepsy in Diffuse Low-Grade Gliomas -- 14. Quality of Life in Low-Grade Gliomas -- 15. Metabolic-Oncological MR Imaging of Diffuse Low-Grade Glioma: A Dynamic Approach -- 16. Positron-Emission Tomography in Diffuse Low-Grade Gliomas -- 17. Dynamics of Diffuse Low-Grade Gliomas and Clinical Implications -- 18. Natural History and Spontaneous Prognostic Factors -- 19. Language and Other Cognitive Evaluations -- 20. Functional MR and Diffusion MR Imaging in Diffuse Low-Grade Gliomas -- 21. Magnetoencephalography, Functional Connectivity and Neural Network Topology in Diffuse Low-Grade Gliomas -- 22. Interactions Between Diffuse Low-Grade Glioma and Brain Plasticity -- 23. Surgery for Diffuse Low-Grade Gliomas: Oncological Considerations -- 24. Surgery for Diffuse Low-Grade Gliomas: Functional Considerations -- 25. Chemotherapy for Diffuse Low-Grade Gliomas -- 26. Radiation Therapy for the Treatment of Diffuse Low-Grade Gliomas -- 27. New Individualized Strategies in Diffuse Low-Grade Gliomas -- 28. Biomathematical Modeling of Diffuse Low-Grade Glioma Behavior -- 29. Towards the Definition of New Endpoints -- 30. Functional Rehabilitation in Patients with Diffuse Low-Grade Glioma -- 31. Early Detection and Management of Incidental Diffuse Low-Grade Gliomas (IDLGG): Towards a "Prophylactic Oncological Neurosurgery" -- 32. The Origins of Diffuse Low-Grade Gliomas: "Functional Theory" Versus "Molecular Theory".
- Format
- e-Book
- Location
- Online
Neurodegenerative diseases : integrative PPPM approach as the medicine of the future
https://libcat.nshealth.ca/en/permalink/provcat32642
Silvia Mandel, editor.
--Dordrecht:
Springer
, c2013.
- Available Online
- View e-Book
- Location
- Online
The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing he…
- Available Online
- View e-Book
- Other Authors
- Mandel, Silvia
- Responsibility
- Silvia Mandel, editor
- Place of Publication
- Dordrecht
- Publisher
- Springer
- Date of Publication
- c2013
- Physical Description
- 1 online resource (xvii, 396 p. : 39 ill., 32 ill. in color)
- Series Vol.
- v. 2
- ISBN
- 9789400758667
- Subjects (MeSH)
- Neurodegenerative Diseases
- Neurosciences
- Neurology
- Subjects (LCSH)
- Medicine
- Neurosciences
- Neurology
- Abstract
- The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments. This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.
- Contents
- What is this book series about? -- Preface -- Introductory chapter -- Individual predispositions in healthy vasospastic individuals: Patient profiling for targeted prevention of 'down-stream' pathologies as cost-effective personalised medicine -- Idiopathic REM sleep behavior disorder as a long-term predictor of neurodegenerative disorders -- New animal models of progressive neurodegeneration: tools for developing predictive diagnostics and identifying presymptomatic therapeutic targets -- Tau pathology: A selected view on the current status -- The Use of Biomarkers for Prediction and Prevention of Alzheimer's and Parkinson's Diseases -- Making clinical trials of Alzheimer's disease delay-of-onset a reality by use of a prognostic genetic biomarker -- An update on CSF biomarkers of Parkinson's disease -- Glaucomatous optic neuropathy: Risk assessment and potential targets for effective prevention and treatments tailored to the patient -- Toward a personalized approach in amyotrophic lateral sclerosis: new developments in diagnosis, genetics, pathogenesis and therapies -- Recent advances in ALS research: perspectives for personalized clinical application -- Exercise in Multiple Sclerosis – an Integral Component of Disease Management -- Bridging the Informatics Gap between Bench and Bedside: Implications to Neurodegenerative Diseases -- Personalized Medicine In Rare Paediatric Neurometabolic Diseases -- Author Index -- Subject Index.
- Format
- e-Book
- Location
- Online
