Sport nutrition
https://libcat.nshealth.ca/en/permalink/provcat43796
Asker Jeukendrup, Michael Gleason.
(Third edition)
--Champaign, IL:
Human Kinetics
, c2019.
- Call Number
- QT 263 J48s 2019
- Location
- Dickson Building
- Call Number
- QT 263 J48s 2019
- Author
- Jeukendrup, Asker E., 1969-
- Other Authors
- Gleson, Michael, 1956-
- Responsibility
- Asker Jeukendrup, Michael Gleason
- Edition
- Third edition
- Place of Publication
- Champaign, IL
- Publisher
- Human Kinetics
- Date of Publication
- c2019
- Physical Description
- xii, 602 pages : illustrations
- ISBN
- 9781492529033
- 9781492567288 (e-book)
- Subjects (MeSH)
- Athletes
- Diet
- Exercise - physiology
- Food
- Physical Fitness - physiology
- Sports Nutritional Physiological Phenomena
- Specialty
- Nutritional Sciences
- Sports Medicine
- Contents
- Nutrients -- Nutrients and recommended intakes -- Fuel sources for muscle and exercise metabolism -- Energy -- Gastric emptying, digestion, and absorption -- Carbohydrate -- Fat -- Protein and amino acids -- Water requirements and fluid balance -- Vitamins and minerals -- Nutrition supplements -- Nutrition and training adaptations -- Nutrition and immune function in athletes -- Body composition -- Weight management -- Eating disorders in athletes -- Personalized nutrition.
- Format
- Book
- Location
- Dickson Building
- Loan Period
- 3 weeks
Genomic and precision medicine : infectious and inflammatory disease
https://libcat.nshealth.ca/en/permalink/provcat43986
edited by Geoffrey S. Ginsburg, Huntington F. Willard.
(3rd ed.)
--London, UK:
Academic Press
, c2019.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
Genomic and Precision Medicine: Inflammation and Metabolic Disorders, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precisi…
- Available Online
- View e-Book
- Other Authors
- Ginsburg, Geoffrey S.
- Responsibility
- edited by Geoffrey S. Ginsburg, Huntington F. Willard
- Edition
- 3rd ed.
- Place of Publication
- London, UK
- Publisher
- Academic Press
- Date of Publication
- c2019
- Physical Description
- 1 online resource
- ISBN
- 9780128014967
- Specialty
- Genetics, Medical
- Precision Medicine
- Abstract
- Genomic and Precision Medicine: Inflammation and Metabolic Disorders, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
Congenital Hyperinsulinism : A Practical Guide to Diagnosis and Management
https://libcat.nshealth.ca/en/permalink/provcat44051
Diva D. De León-Crutchlow, Charles A. Stanley, editors.
--Cham:
Humana Press
, 2019.
- Available Online
- View e-Book
- Location
- Online
This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a “personalized” approach to management according to the type of hyperinsulinism, and particularly according to the li…
- Available Online
- View e-Book
- Other Authors
- De León-Crutchlow, Diva D.
- Stanley, Charles A.
- Responsibility
- Diva D. De León-Crutchlow, Charles A. Stanley, editors
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xv, 165 p.) : 22 illus., 12 illus. in color
- Series
- Contemporary Endocrinology
- Series Title
- Contemporary endocrinology
- ISBN
- 9783030029616
- 9783030029609 (Print ed.)
- 9783030029623 (Print ed.)
- ISSN
- 2523-3785
- Specialty
- Diabetes Mellitus
- Abstract
- This unique book is a practical guide for the clinician faced with the challenge of diagnosing and managing neonates, infants and children with congenital hyperinsulinism (HI), within the framework of pathophysiology and molecular genetics. Major advances have been made in HI research over the past two decades, and with this better understanding of the molecular genetics of HI, a “personalized” approach to management according to the type of hyperinsulinism, and particularly according to the likelihood of focal hyperinsulinism, is starting to emerge. The opening chapter discusses HI diagnosis using biochemical approaches and phenotype characterization. The various forms of HI are then presented in detail in three main categories: diazoxide-responsive, diazoxide-unresponsive and syndromic HI. Both medical and surgical management strategies are then discussed, covering imaging, histology, surgical approach, and post-operative management. Complications, such as feeding problems, and long-term outcomes, such as neurodevelopmental issues, are carefully considered in the final chapter. Practical and user-friendly, Congenital Hyperinsulinism is the go-to resource for pediatric endocrinologists, residents and fellows, general pediatricians and neonatologists.
- Contents
- Approach to the Diagnosis of Neonates and Infants with Persistent Hypoglycemia -- Diazoxide-Responsive Forms of Congenital Hyperinsulinism -- Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism -- Syndromic Causes of Congenital Hyperinsulinism -- Molecular Diagnosis of Congenital Hyperinsulinism -- Medical Management of Hyperinsulinism -- 18F-DOPA PET -- Histopathology of the Pancreas in Congenital Hyperinsulinism -- Surgery for Congenital Hyperinsulinism -- Perioperative Management of Hyperinsulinism -- Management of the Child with Persistent Hypoglycemia After Surgery -- Management of Diabetes and Pancreatic Insufficiency after Pancreatectomy -- Feeding Problems in Congenital Hyperinsulinism -- Neurodevelopmental Outcomes.
- Format
- e-Book
- Location
- Online
Uterine Cervical Cancer : Clinical and Therapeutic Perspectives
https://libcat.nshealth.ca/en/permalink/provcat44071
Samir A. Farghaly, editor.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This volume provides a broad background of the basic sciences, clinical and therapeutic aspects, and management of uterine cervical cancer. It offers state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the uterine cervix, and provides a better understanding of the molecular and cellular events that underlie uterine cervical cancer. Uterine Cervical Cancer: Clinical and Therapeutic Perspectives contains extensive, updated information o…
- Available Online
- View e-Book
- Other Authors
- Farghaly, Samir A.
- Responsibility
- Samir A. Farghaly, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xviii, 299 p.) : 45 illus. in color
- ISBN
- 9783030027018
- 9783030027001 (Print ed.)
- 9783030027025 (Print ed.)
- Subjects (MeSH)
- Uterine Cervical Neoplasms
- Abstract
- This volume provides a broad background of the basic sciences, clinical and therapeutic aspects, and management of uterine cervical cancer. It offers state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the uterine cervix, and provides a better understanding of the molecular and cellular events that underlie uterine cervical cancer. Uterine Cervical Cancer: Clinical and Therapeutic Perspectives contains extensive, updated information on the promising new developments in the diagnosis and management of uterine cervical cancer. It will serve as an invaluable resource for all clinicians and basic medical scientists caring for women with uterine cervical cancer, including attending surgeons, physicians, clinical fellows, and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.
- Contents
- Epidemiology of Cervical Cancer -- Prevention of Cervical Cancer -- Current Advances in Optical Screening for Cervical Cancer -- Cervical Cancer Screening in Low and Middle Income Countries -- Pathology and Molecular Diagnosis of Cervical Cancer and Precursor Lesions -- Uterine Cervical Cancer in Woman with HIV Infection -- Immunotherapy for Pre-Cancerous Lesions of the Uterine Cervix -- Utility of Sentinel Node Biopsy in Cervical Cancer -- Fertility Sparing Surgery for Early Stage Uterine Cervical Cancer -- Standard and Novel Surgical Treatments in Cervical Cancer. Management of Recurrent Uterine Cervical Cancer -- Chemotherapy for Cervical Cancer -- Potential Biomarkers for Personalized Radiation Therapy for Patients with Uterine Cervical Cancer -- Radiotherapy for Uterine Cervical Cancer -- Quality of Life in Woman with Cervical Cancer.
- Format
- e-Book
- Location
- Online
Personalized Psychiatry : Big Data Analytics in Mental Health
https://libcat.nshealth.ca/en/permalink/provcat44141
Ives Cavalcante Passos, Benson Mwangi, Flávio Kapczinski, editors.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book integrates the concepts of big data analytics into mental health practice and research. Mental disorders represent a public health challenge of staggering proportions. According to the most recent Global Burden of Disease study, psychiatric disorders constitute the leading cause of years lost to disability. The high morbidity and mortality related to these conditions are proportional to the potential for overall health gains if mental disorders can be more effectively diagnosed and tr…
- Available Online
- View e-Book
- Other Authors
- Passos, Ives Cavalcante
- Mwangi, Benson
- Kapczinski, Flávio
- Responsibility
- Ives Cavalcante Passos, Benson Mwangi, Flávio Kapczinski, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xv, 180 p.) : 24 illus., 21 illus. in color
- ISBN
- 9783030035532
- 9783030035525 (Print ed.)
- 9783030035549 (Print ed.)
- Subjects (MeSH)
- Data Analysis
- Psychiatry - methods
- Specialty
- Data Science
- Precision Medicine
- Psychiatry
- Abstract
- This book integrates the concepts of big data analytics into mental health practice and research. Mental disorders represent a public health challenge of staggering proportions. According to the most recent Global Burden of Disease study, psychiatric disorders constitute the leading cause of years lost to disability. The high morbidity and mortality related to these conditions are proportional to the potential for overall health gains if mental disorders can be more effectively diagnosed and treated. In order to fill these gaps, analysis in science, industry, and government seeks to use big data for a variety of problems, including clinical outcomes and diagnosis in psychiatry. Multiple mental healthcare providers and research laboratories are increasingly using large data sets to fulfill their mission. Briefly, big data is characterized by high volume, high velocity, variety and veracity of information, and to be useful it must be analyzed, interpreted, and acted upon. As such, focus has to shift to new analytical tools from the field of machine learning that will be critical for anyone practicing medicine, psychiatry and behavioral sciences in the 21st century. Big data analytics is gaining traction in psychiatric research, being used to provide predictive models for both clinical practice and public health systems. As compared with traditional statistical methods that provide primarily average group-level results, big data analytics allows predictions and stratification of clinical outcomes at an individual subject level. Personalized Psychiatry: Big Data Analytics in Mental Health provides a unique opportunity to showcase innovative solutions tackling complex problems in mental health using big data and machine learning. It represents an interesting platform to work with key opinion leaders to document current achievements, introduce new concepts as well as project the future role of big data and machine learning in mental health.
- Contents
- 1. Big Data and Machine Learning Techniques Meet Health Sciences -- 2. Major Challenges and Limitations of Big Data Analytics -- 3. A Clinical Perspective on Big Data in Mental Health -- 4. Big Data Guided Interventions: Predicting Treatment Response -- 5. The Role of Big Data Analytics in Predicting Suicide -- 6. Emerging Shifts in Neuroimaging Data Analysis in the Era of “Big Data" -- 7. Phenomapping: Methods and Measures for Deconstructing Diagnosis in Psychiatry -- 8. How to integrate Data from Multiple Biological Layers in Mental Health? -- 9. Ethics in the Era of Big Data.
- Format
- e-Book
- Location
- Online
Heart Failure
https://libcat.nshealth.ca/en/permalink/provcat44168
David S. Feldman, Paul Mohacsi, editors.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This textbook offers an up-to-date, user-friendly guide on the evaluation, diagnosis and treatment of this most important aspect of cardiovascular disease. Each chapter is dedicated to providing comprehensive coverage of every aspect of heart failure from cardiac signs and symptoms through imaging and the genetic basis for disease to surgery, interventions, treatment and preventative cardiology. Heart Failure provides the trainee and practising cardiologists, cardiac surgeon, vascular surgeon, …
- Available Online
- View e-Book
- Other Authors
- Feldman, David S.
- Mohacsi, Paul
- Responsibility
- David S. Feldman, Paul Mohacsi, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (ix, 328 p.) : 85 illus., 59 illus. in color
- Series
- Cardiovascular Medicine
- Series Title
- Cardiovascular medicine
- ISBN
- 9783319981840
- 9783319981826 (Print ed.)
- 9783319981833 (Print ed.)
- ISSN
- 2363-5053
- Subjects (MeSH)
- Heart Failure - physiopathology
- Heart Failure - therapy
- Specialty
- Cardiology
- Abstract
- This textbook offers an up-to-date, user-friendly guide on the evaluation, diagnosis and treatment of this most important aspect of cardiovascular disease. Each chapter is dedicated to providing comprehensive coverage of every aspect of heart failure from cardiac signs and symptoms through imaging and the genetic basis for disease to surgery, interventions, treatment and preventative cardiology. Heart Failure provides the trainee and practising cardiologists, cardiac surgeon, vascular surgeon, diabetologist, cardiac radiologist and any physician who manages cardiac patients with extensive guidance on the diagnosis and management of a range of conditions related to heart failure. It is therefore, a critical resource for all cardiology practitioners, trainees’ .
- Contents
- Part I. Definition, Epidemiology & Etiology -- 1. Epidemiology of Heart Failure -- Part II. Pathophysiology -- 2. Inter- and Intracellular Mechanisms of Cardiac Remodeling, Hypertrophy and Dysfunction -- 3. Inflammation and Innate Immunity -- Part III. Special Pathophysiology -- 4. Comorbidities and Co-Existing Conditions in Heart Failure Around Pregnancy -- 5. Myocardial Dysfunction Associated with Cancer Therapy -- Part IV. Diagnostics -- 6. Diagnosis of Heart Failure -- Part V. Therapeutics -- 7. Pharmacotherapy in Heart Failure (I): Renin-Angiotensin-Aldosterone System (incl. ARNI), Diuretics, Digoxin and Statins -- 8. Pharmacotherapy in Heart Failure (II): Beta Adrenergic Blocking Drugs, Ivabradine, Hydralazine and Nitrates -- 9. Device Therapy in the Heart Failure -- 10. Interpretation of Clinical Trials in the Context of Personalized/Individualized Medicine and End of Life Issues -- Part VI. Hospitalized Patients and Comorbidities -- 11. Inpatient Therapeutic Options -- 12. Anemia and Iron Deficiency in Heart Failure -- 13. Psychological Comorbidities in Heart Failure -- Part VII. Cardiac Surgery in HF -- 14. Surgical Intervention on the Mitral and Tricuspid Valves in Patients with Left Ventricular Dysfunction and Heart Failure -- 15. Myocardial Revascularization in Patients with Left Ventricular Dysfunction -- Part VIII. Heart Transplantation (I, Surgical) -- 16. Early Postoperative Management -- 17. Organ Preservation and Implantation -- Part IX. Heart Transplantation (II, Medical) -- 18. Patient Selection, Pretransplant Management, Donor and Recipient Matching -- Part X. Heart Transplantation (III) -- 19. Immunosuppression, Including Drug Toxicity, Interactions, New Immunosuppressants in the Pipeline -- 20. Acute Rejection -- 21. Cardiac Allograft Vasculopathy -- Part XI. Pulmonary Hypertension -- 22. Pulmonary Hypertension -- Part XII. Mechanical Circulatory Support -- 23. MCS: Patient Selection -- 24. Types of Circulatory Support Devices -- 25. Veno-Arterial ECMO -- 26. Bridge to Recovery (BTR) -- 27. Mechanical Circulatory Support Part II; Management of Devices After Implantation, Incl. Complications.
- Format
- e-Book
- Location
- Online
Fundamentals of Clinical Data Science
https://libcat.nshealth.ca/en/permalink/provcat44198
Pieter Kubben, Michel Dumontier, Andre Dekker, editors.
--Cham:
SpringerOpen
, 2019.
- Available Online
- View e-Book
- Access
- Open access
- Location
- Online
This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third se…
- Available Online
- View e-Book
- Other Authors
- Kubben, Pieter
- Dumontier, Michel
- Dekker, Andre
- Responsibility
- Pieter Kubben, Michel Dumontier, Andre Dekker, editors
- Place of Publication
- Cham
- Publisher
- SpringerOpen
- Date of Publication
- 2019
- Physical Description
- 1 online resource (viii, 219 p.) : 45 illus., 35 illus. in color
- ISBN
- 9783319997131
- 9783319997124 (Print ed.)
- 9783319997148 (Print ed.)
- Specialty
- Medical Informatics
- Abstract
- This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.
- Contents
- Part I. Data Collection -- 1. Data Sources -- 2. Data at Scale -- 3. Standards in Healthcare Data -- 4. Research Data Stewardship for Healthcare Professionals -- 5. The EU’s General Data Protection Regulation (GDPR) in a Research Context -- Part II. From Data to Model -- 6. Preparing Data for Predictive Modelling -- 7. Extracting Features from Time Series -- 8. Prediction Modeling Methodology -- 9. Diving Deeper into Models -- 10. Reporting Standards and Critical Appraisal of Prediction Models -- Part III. From Model to Application -- 11. Clinical Decision Support Systems -- 12. Mobile Apps -- 13. Optimizing Care Processes with Operational Excellence & Process Mining -- 14. Value-Based Health Care Supported by Data Science.
- Access
- Open access
- Format
- e-Book
- Location
- Online
Psycho-Oncology for the Clinician : The Patient Behind the Disease
https://libcat.nshealth.ca/en/permalink/provcat44272
Shulamith Kreitler.
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
This volume strives to give oncologists and other medical practitioners a thorough picture of the oncology patient. It’s designed to show that psychological needs of the patient are an important aspect that should be considered for optimizing the effects of cancer treatment, no less than genetic, immunological, physiological and other medical features that are often considered as necessary components of personalized medicine. Using evidence-based information, the book describes the different wa…
- Available Online
- View e-Book
- Author
- Kreitler, Shulamith
- Responsibility
- Shulamith Kreitler
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xiii, 312 p.)
- ISBN
- 9783030061265
- 9783030061241 (Print ed.)
- 9783030061258 (Print ed.)
- Subjects (MeSH)
- Medical Oncology - methods
- Neoplasms - psychology
- Patients - psychology
- Psycho-Oncology
- Specialty
- Psycho-Oncology
- Abstract
- This volume strives to give oncologists and other medical practitioners a thorough picture of the oncology patient. It’s designed to show that psychological needs of the patient are an important aspect that should be considered for optimizing the effects of cancer treatment, no less than genetic, immunological, physiological and other medical features that are often considered as necessary components of personalized medicine. Using evidence-based information, the book describes the different ways cancer touches upon a person’s life, including emotional, physical, and social changes, important decisions, and support structure. It also details the phases every cancer patient encounters along the way, from getting tested and waiting for the diagnosis, to treatments, survival, and confronting one’s mortality. Psycho-oncology for the Clinician will serve to contribute to the further scientific development of psycho-oncology, expand its use as a treatment modality, strengthen its status as an essential component of cancer care, and promote the acceptance of psycho-oncology as the new evidence-based constituent of personalized medicine in oncology.
- Contents
- The History of Psycho-oncology -- The Special Characteristics of Oncology and Psycho-Oncology -- The Phases of the Confrontation with Cancer -- Determinants, Risk Factors, and Protective Factors for Cancer: Environmental, Physiological and Demographic -- Psychosocial Risk Factors for Cancer -- The Impact of Cancer -- Major Decision in the Life of Cancer Patients -- Treatments and Inventions in Cancer -- Coping with Cancer -- Quality of Life -- The Family in Cancer -- Relations with the Physicians and Medical Institutions -- Confronting Dying and Death -- Specific Cancer Diseases: The Psychological Perspective -- Special Populations of Patients -- The Caretakers.
- Format
- e-Book
- Location
- Online
Vitamin E in Human Health
https://libcat.nshealth.ca/en/permalink/provcat44326
Peter Weber, Marc Birringer, Jeffrey B. Blumberg, Manfred Eggersdorfer, Jan Frank, editors.
--Cham:
Humana Press
, 2019.
- Available Online
- View e-Book
- Location
- Online
This comprehensive volume examines the role of vitamin E as an essential micronutrient in human health and its extensive clinical benefits. Sections cover a wide breadth of topics, including vitamin E intake and recommended daily allowance, understanding the biological activities of Vitamin E and observed physiological effects, benefits of vitamin E on upper respiratory infections, cardiovascular disease, age-related macular degeneration, Alzheimer’s disease, and intake safety. The text serves …
- Available Online
- View e-Book
- Responsibility
- Peter Weber, Marc Birringer, Jeffrey B. Blumberg, Manfred Eggersdorfer, Jan Frank, editors
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xxxix, 467 p.) : 103 illus., 58 illus. in color
- Series
- Nutrition and Health
- Series Title
- Nutrition and health (Totowa, N.J.)
- ISBN
- 9783030053154
- 9783030053147 (Print ed.)
- 9783030053161 (Print ed.)
- Subjects (MeSH)
- alpha-Tocopherol
- Micronutrients
- Vitamins
- Subjects (LCSH)
- Vitamin E
- Specialty
- Nutritional Sciences
- Abstract
- This comprehensive volume examines the role of vitamin E as an essential micronutrient in human health and its extensive clinical benefits. Sections cover a wide breadth of topics, including vitamin E intake and recommended daily allowance, understanding the biological activities of Vitamin E and observed physiological effects, benefits of vitamin E on upper respiratory infections, cardiovascular disease, age-related macular degeneration, Alzheimer’s disease, and intake safety. The text serves to emphasize the importance of vitamin E in relation to disease prevention as well as to raise awareness of the number of health conditions where an increased intake of vitamin E can be of potential significance. It explores vitamin E in an up-to-date, science based, applicable real-life perspective and offers pragmatic solutions for its safe and personalized use beyond the various methodological and statistical controversies. Intended for the medical and nutritional community, Vitamin E in Human Health will not only be an expansive resource for healthcare professionals, but also makes efforts to stimulate increased support for vitamin E research and further exploration of the safe and efficacious use for this essential micronutrient.
- Contents
- Introduction: Why (Another) Book on Vitamin E? -- Part I. Biochemistry, Metabolism and Molecular Effects of Vitamin E -- History of Vitamin E Research -- Antioxidative Activity of Vitamin E -- Bioavailability and Metabolism of Vitamin E -- Occurrence and Bioactivities of Minor Vitamin E Derivatives -- Bioactivity of Vitamin E Long-Chain Metabolites -- Gene-regulatory Activity of Vitamin E -- Metabolomic Approaches in Vitamin E Research -- The Tocopherol Transfer Protein: Regulator of Vitamin E Status -- The Role of Lipid Rafts in Mediating the Anticancer Effects of y-Tocotrienol -- Interaction between Vitamin E and Polyunsaturated Fatty Acids -- Part II. A Global View on Vitamin E Intakes and Status -- The Challenge of Defining Daily Intake Recommendations: Vitamin E and Polyunsaturated Fatty Acids -- Vitamin E Intake and Serum Levels in the General Population: a Global Perspective -- Vitamin E Serum Levels and the Challenge to Correct for Lipids: Accounting for the Usual Double Correction for Variance shared by Total Cholesterol and Fasting Triglycerides Reveals New Insights into the Association with the One Carbon Pathway -- Stability of Vitamin E in Foods -- Part III. Safety of Vitamin E and Interactions with Other Nutrients and Drugs -- Vitamin E and Mortality: A Critical Perspective of the Conflicting Meta-Analysis Outcomes -- Vitamin E: Drug Interactions -- Vitamin E: Interactions with Vitamin K and other Bioactive Compounds -- Part IV. Benefits of Vitamin E on Human Health and Disease -- Clinical Cardiovascular Disease Trials: The Vitamin E Case -- Haptoglobin Genotype and a Promising Pharmacogenomic Approach to Prevent Diabetic Atherothrombosis with Vitamin E Supplementation -- Vitamin E and Metabolic Syndrome -- Vitamin E in nonalcoholic Fatty Liver Disease -- The Role of Vitamin E in Aging and Alzheimer's Disease -- The Impact of Vitamin E Isoforms on Asthma and Allergy -- Vitamin E, Immune Function, and Protection Against Infection -- Vitamin E and Air Pollution -- The Role of Vitamin E in Pregnancy -- Part V. Public Health Implications of Vitamin E - Vitamin E and Health Care Costs: Models to Assess the Impact -- Do Consumers Care about Micronutrients? A Perspective on the Possible Role of Vitamin E in the Dietary Choices of Consumers -- Addressing Key Knowledge Gaps in Nutrition and the Impact of Funding Priorities in Human Nutrition.
- Format
- e-Book
- Location
- Online
CT of the Heart
https://libcat.nshealth.ca/en/permalink/provcat44328
U. Joseph Schoepf, editor.
(Second edition)
--Totowa, NJ:
Humana Press
, 2019.
- Available Online
- View e-Book
- Location
- Online
This book is a comprehensive and richly-illustrated guide to cardiac CT, its current state, applications, and future directions. While the first edition of this text focused on what was then a novel instrument looking for application, this edition comes at a time where a wealth of guideline-driven, robust, and beneficial clinical applications have evolved that are enabled by an enormous and ever growing field of technology. Accordingly, the focus of the text has shifted from a technology-centri…
- Available Online
- View e-Book
- Other Authors
- Schoepf, U. Joseph
- Responsibility
- U. Joseph Schoepf, editor
- Edition
- Second edition
- Alternate Title
- Computed tomography of the heart
- Place of Publication
- Totowa, NJ
- Publisher
- Humana Press
- Date of Publication
- 2019
- Physical Description
- 1 online resource (xxvii, 931 p.) : 576 illus., 352 illus. in color
- Series
- Contemporary Medical Imaging
- Series Title
- Contemporary medical imaging
- ISBN
- 9781603272377
- 9781603272360 (Print ed.)
- 9781934115961 (Print ed.)
- ISSN
- 2626-6431
- Subjects (MeSH)
- Cardiovascular Diseases - diagnostic imaging
- Heart - diagnostic imaging
- Tomography, X-Ray Computed - methods
- Specialty
- Cardiology
- Diagnostic Imaging
- Abstract
- This book is a comprehensive and richly-illustrated guide to cardiac CT, its current state, applications, and future directions. While the first edition of this text focused on what was then a novel instrument looking for application, this edition comes at a time where a wealth of guideline-driven, robust, and beneficial clinical applications have evolved that are enabled by an enormous and ever growing field of technology. Accordingly, the focus of the text has shifted from a technology-centric to a more patient-centric appraisal. While the specifications and capabilities of the CT system itself remain front and center as the basis for diagnostic success, much of the benefit derived from cardiac CT today comes from avant-garde technologies enabling enhanced visualization, quantitative imaging, and functional assessment, along with exciting deep learning, and artificial intelligence applications. Cardiac CT is no longer a mere tool for non-invasive coronary artery stenosis detection in the chest pain diagnostic algorithms; cardiac CT has proven its value for uses as diverse as personalized cardiovascular risk stratification, prediction, and management, diagnosing lesion-specific ischemia, guiding minimally invasive structural heart disease therapy, and planning cardiovascular surgery, among many others. This second edition is an authoritative guide and reference for both novices and experts in the medical imaging sciences who have an interest in cardiac CT.
- Contents
- Part I. Where We Were -- History of Cardiac CT: A Personal Story -- Evolution of Radiation Dose from Cardiac CT -- The Long March into Clinical Practice: Cardiac CT and Its Competitors -- Part II. Where We Are: Human Requisites -- Cardiac Computed Tomography: A Team Sport -- Cardiac CT: Credentialing and Accreditation -- Part III. Where We Are: Technical and Operational Requisites -- Cardiac CT Platforms: State of the Art -- Principles of Cardiac CT Image Acquisition -- Dual Energy and Spectral CT Techniques in Cardiovascular Imaging -- Drugs in Cardiac CT -- Contrast Media Injection Protocols in CT Coronary Angiography -- Cardiovascular CT: Image Reconstruction -- The Challenging Patient -- Cardiac CT: Contemporary Clinical Image Data Display, Analysis, and Quantification -- Workflow Optimization -- Defining the Role and Benefits of a 3D Laboratory for Cardiovascular -- Structured Reporting for Cardiac CT -- Integration of CT Data into Clinical Workflows: Role of Modern IT Infrastructure including Cloud Technology -- Thoughts on Coding and Reimbursement -- Part IV. Where We Are: Cardiac CT Fundamentals -- Pathology and Pathophysiology of Coronary Atherosclerotic Plaques -- CT Cardiac Anatomy -- Patient Selection: When to Use Cardiac CT versus Other Imaging or Non-Imaging Tests -- Current Guidelines -- Part V. Where We Are: Risk Stratification and Management -- Clinical Application of the Coronary Artery Calcium Score and Implications for Cardiovascular Disease Prevention -- The Many Uses of Epicardial Fat Measurements -- Part VI. Where We Are: Non-invasive Coronary Artery Imaging -- Nonatherosclerotic Coronary Artery Disease -- The Many Faces of Atherosclerosis -- Use of Coronary Computed Tomography Angiography in Cardiac Risk Assessment for Non-Cardiac Surgery -- Chronic Chest Pain -- Coronary CT Angiography for Evaluation of Acute Coronary Syndrome in the Emergency Department -- The Role of Cardiac CT in Patients with Metabolic Disorders -- CT for Guiding Successful Revascularization -- Multidetector CT Angiography for Coronary Bypass Graft Assessment and Reoperative Cardiac Surgery -- Stent Assessment -- Part VII. Where We Are: CT Assessment of Ventricular Function -- CT of Cardiac Function and Wall Motion -- Three-Chamber Function with Cardiac CT -- Part VIII. Where We Are: Cardiac Imaging Outside the Coronaries -- Diseases of the Myocardium and Pericardium -- CT of Cardiac and Paracardiac Masses -- Valvular Heart Disease and Prostheses -- Part IX. Where We Are: Transcatheter Therapy Planning -- CT in the Context of Transcatheter Aortic Valve Replacement -- CT for Minimally Invasive Repair of Mitral Valve and Other Structural Heart Disease -- Cardiac CT: Electrophysiological Applications -- Cardiac Devices -- Part X. Where We Are: Congenital Heart Disease -- Special Technique Considerations for Congenital Heart Disease Imaging -- CT of Coronary Artery Anomalies -- CT Spectrum of Congenital Heart Disease -- The Use of Cardiovascular CT in Repaired CHD -- Cardiac CT in the Setting of Heart Transplantation -- Part XI. Where We Are: The Heart and Beyond -- CT Imaging of the Heart-Lung Axis -- Ischemic Stroke: The Role of Cardiac CT -- Incidental Findings on CT angiography and How to Manage Them -- A Test on the Move: Cardiac CT in China as a Case Study -- Part XII. Where We Are: The Bigger Picture -- Prognosis and Outcome: State of the Evidence -- Cardiac CT: Comparative Cost-Effectiveness -- Barriers to Greater Clinical Implementation -- Part XIII. Where We Are Going: The Genes and the Heart -- Differences and Disparities in Cardiovascular Medicine Related to Gender, Race, and Ethnicity: The Role of Cardiac CT -- Cardiac CT Radiomics -- Part XIV. Where We Are Going: Risk Prediction and Management: The Next Wave -- Coronary CT Angiography for Screening, Risk Stratification, and Management of Asymptomatic Patients: State of the Evidence -- Advanced Methods for Coronary Artery Plaque Analysis -- Part XV. Where We Are Going: Lesion-specific Ischemia, Infarction, and Viability -- Transluminal Attenuation Gradient and Other CT Techniques for Gauging Lesion Significance -- CT Angiography Derived Fractional Flow Reserve -- CT Myocardial Perfusion Imaging: Arterial First Pass Imaging -- Myocardial Perfusion Imaging: Dual-Energy Approaches -- Dynamic Myocardial CT Perfusion Imaging -- CT’s Role for Myocardial Viability Assessment -- Part XVI. Where We Are Going: The Road Ahead -- Coronary CT Angiography as the Gatekeeper to the Cathlab: Where Are We? -- 3D Printing from Cardiac CT Images -- Future Technological Advances in Cardiac CT.
- Format
- e-Book
- Location
- Online
Hepatocellular Carcinoma : Translational Precision Medicine Approaches
https://libcat.nshealth.ca/en/permalink/provcat44371
Yujin Hoshida, editor.
--Cham:
Humana Press
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment opti…
- Available Online
- View e-Book
- Other Authors
- Hoshida, Yujin
- Responsibility
- Yujin Hoshida, editor
- Place of Publication
- Cham
- Publisher
- Humana Press
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xv, 364 p.) : 56 illus., 37 illus. in color
- Series Title
- Molecular and translational medicine
- ISBN
- 9783030215408
- 9783030215392 (Print ed.)
- 9783030215415 (Print ed.)
- 9783030215422 (Print ed.)
- ISSN
- 2197-7852
- Subjects (MeSH)
- Carcinoma, Hepatocellular - diagnosis
- Carcinoma, Hepatocellular - therapy
- Precision Medicine
- Translational Medical Research
- Abstract
- This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
- Contents
- Part I: Clinical Demographics and Management -- 1. Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care -- 2. Hepatocellular Carcinoma Surveillance and Staging -- 3. Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance -- Part II: Diagnosis and Prognostication -- 4. Radiological Diagnosis and Characterization of HCC -- 5. Analysis of Hepatocellular Carcinoma Tissue for Biomarker and Therapeutic Target Discovery -- 6. Molecular Subtypes and Genomic Signatures of Hepatocellular Carcinoma for Prognostication and Therapeutic Decision Making -- 7. Liquid Biopsy in Hepatocellular Carcinoma -- Part III: Treatment -- 8. Surgical Therapies in Hepatocellular Carcinoma -- 9. Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began To Where We Are Going -- 10. Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and Radiotherapy -- 11. Molecular-targeted Therapies in Hepatocellular Carcinoma -- 12. Immune Therapies -- 13. Prevention Strategies for Hepatocellular Carcinoma -- Part IV: Molecular Pathogenesis and Therapeutic Discovery -- 14. Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma -- 15. Stromal and Immune Drivers of Hepatocarcinogenesis -- 16. Experimental Models for Preclinical Research in Hepatocellular Carcinoma.
- Format
- e-Book
- Location
- Online
Multislice CT
https://libcat.nshealth.ca/en/permalink/provcat44385
Konstantin Nikolaou, Fabian Bamberg, Andrea Laghi, Geoffrey D. Rubin, editors.
(Fourth edition)
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
The fourth edition of this well-received book offers a comprehensive update on recent developments and trends in the clinical and scientific applications of multislice computed tomography. Following an initial section on the most significant current technical aspects and issues, detailed information is provided on a comprehensive range of diagnostic applications. Imaging of the head and neck, the cardiovascular system, the abdomen, and the lungs is covered in depth, describing the application o…
- Available Online
- View e-Book
- Other Authors
- Nikolaou, Konstantin
- Bamberg, Fabian
- Laghi, Andrea
- Rubin, Geoffrey D.
- Responsibility
- Konstantin Nikolaou, Fabian Bamberg, Andrea Laghi, Geoffrey D. Rubin, editors
- Edition
- Fourth edition
- Alternate Title
- Multislice computed tomography
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (x, 1141 p.) : 729 illus., 213 illus. in color
- Series
- Medical Radiology. Diagnostic Imaging
- Series Title
- Medical radiology (Series)
- ISBN
- 9783319425863
- 9783319425856 (Print ed.)
- 9783319425870 (Print ed.)
- Subjects (MeSH)
- Tomography, X-Ray Computed - methods
- Specialty
- Diagnostic Imaging
- Abstract
- The fourth edition of this well-received book offers a comprehensive update on recent developments and trends in the clinical and scientific applications of multislice computed tomography. Following an initial section on the most significant current technical aspects and issues, detailed information is provided on a comprehensive range of diagnostic applications. Imaging of the head and neck, the cardiovascular system, the abdomen, and the lungs is covered in depth, describing the application of multislice CT in a variety of tumors and other pathologies. Emerging fields such as pediatric imaging and CT-guided interventions are fully addressed, and emergency CT is also covered. Radiation exposure, dual-energy imaging, contrast enhancement, image postprocessing, CT perfusion imaging, and CT angiography all receive close attention. The new edition has been comprehensively revised and complemented by contributions from highly experienced and well-known authors who offer diverse perspectives, highlighting the possibilities offered by the most modern multidetector CT systems. This book will be particularly useful for general users of CT systems who wish to upgrade and enhance not only their machines but also their knowledge.
- Contents
- Part I. Techniques -- Multi-slice CT: Current Technology and Future Developments -- Radiation Dose Optimization in CT -- Spectral CT/Dual-Energy CT -- Contrast Enhancement at CT -- Image Processing from 2D to 3D -- Perfusion CT: Technical Aspects -- Part II. Neuro/ENT -- Stroke/Cerebral Perfusion CT: Technique and Clinical Applications -- CT Diagnostics in Brain Tumors -- MDCT in Neurovascular Imaging -- Anatomy and Pathology of the Temporal Bone -- Dental CT: Pathologic Findings in the Teeth and Jaws -- Anatomy and Corresponding Oncological Imaging of the Head and Neck -- Part III. Chest -- Interstitial Lung Diseases -- Pneumonia -- CT of the Airways -- Lung Cancer Screening -- Chest Neoplasias -- CT of Pulmonary Embolism: Imaging Update -- COPD -- Part IV. Abdomen -- Focal Lesions in Non-cirrhotic Liver -- Cirrhotic Liver -- Pancreatic Tumors -- Acute and Chronic Pancreatitis -- Spleen -- Imaging of the Stomach and Esophagus Using CT and PET/CT Techniques - Small Bowel MDCT -- Imaging of Large Bowel with Multidetector Row CT -- Peritoneal Surface Malignancy -- Multislice PET/CT in Neuroendocrine Tumors -- Adrenals -- Kidneys, Ureters, and Bladder -- Part V. Cardiovascular -- Technical Innovations and Concepts in Coronary CT -- Noninvasive Coronary Artery Imaging -- Pre- and Postinterventional/Surgical Evaluation by CT -- Computed Tomography in the Management of Electrophysiology Procedures -- Functional Cardiac CT Angiography -- CT Angiography of the Peripheral Arteries -- Acute Aortic Syndromes -- CT Venography -- Aortic Aneurysm and Stent Graft Assessment -- Part VI. Interventions -- CT-Guided Biopsy and Drainage -- CT-Guided Spinal Interventions: Vertebroplasty/Kyphoplasty -- CT-Guided Tumor Ablation -- Functional CT for Image-Guided Personalized Tumor Interventions -- Part VII. Pediatrics -- Dedicated CT Protocols for Children -- Congenital Heart Disease in Children -- Chest CT Imaging in Children -- CT of the Pediatric Abdomen -- Part VIII. Miscellaneous Topics -- Emergency CT -- Clinical Application of Musculoskeletal CT: Trauma, Oncology, and Postsurgery -- Incidental Findings in Multislice CT of the Body -- Correction to: Chest Neoplasias -- Correction to: Imaging of the Stomach and Esophagus Using CT and PET/CT Techniques.
- Format
- e-Book
- Location
- Online
Oncology of CNS Tumors
https://libcat.nshealth.ca/en/permalink/provcat44456
Jörg-Christian Tonn, David A. Reardon, James T. Rutka, Manfred Westphal, editors.
(Third edition)
--Cham:
Springer
, 2019.
- Available Online
- View e-Book
- Location
- Online
The new edition has been completely revised to reflect the continually evolving landscape of neuro-oncology and provide readers with a thorough update that will inform their clinical practice. Since the previous edition, molecular neuropathology has progressed considerably, leading to a new understanding of specific clinical entities with corresponding changes in classification and treatment concepts. Moreover, tumor biology has become better integrated with clinical neuro-oncology in truly tra…
- Available Online
- View e-Book
- Responsibility
- Jörg-Christian Tonn, David A. Reardon, James T. Rutka, Manfred Westphal, editors
- Edition
- Third edition
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- 2019
- Physical Description
- 1 online resource (x, 794 p.) : 276 illus., 113 illus. in color
- ISBN
- 9783030041526
- 9783030041519 (Print ed.)
- 9783030041533 (Print ed.)
- Subjects (MeSH)
- Central Nervous System Neoplasms - diagnosis
- Central Nervous System Neoplasms - therapy
- Specialty
- Medical Oncology
- Neurology
- Abstract
- The new edition has been completely revised to reflect the continually evolving landscape of neuro-oncology and provide readers with a thorough update that will inform their clinical practice. Since the previous edition, molecular neuropathology has progressed considerably, leading to a new understanding of specific clinical entities with corresponding changes in classification and treatment concepts. Moreover, tumor biology has become better integrated with clinical neuro-oncology in truly translational efforts. These advances receive detailed attention. In addition, the structure of the book has been adapted to align with the revised 2016 version of the WHO Brain Tumor Classification. Once again, the contributors have been carefully selected as leading experts in the field. Oncology of CNS Tumors is already established as a widely used reference, and this new edition will provide optimal value for highly specialized comprehensive neuro-oncology centers as well as practicing clinicians and researchers.
- Contents
- Part I. General Aspects in Neurooncology -- 1. Pathology and Classification of Tumors of the Central Nervous System -- 2. Etiological and Epidemiological Aspects -- 3. Imaging of Central Nervous System Tumors -- 4. Tumor Biology -- 5. Concepts of Personalized Medicine in Neuro-oncology -- 6. Local Therapies -- Part II. Neurooncology of the Cranial Space -- 7. Tumors of the Skull Including Chordoma -- 8. Meningiomas and Meningeal Tumors -- 9. WHO II and III Gliomas -- 10. Glioblastoma -- 11. Ependymomas and Tumors of the Ventricular System -- 12. Pituitary Adenomas -- 13. Tumors of the Pineal Region -- 14. Tumors of the Cranial Nerves -- 15. Hemangioblastoma and von Hippel-Lindau Disease -- 16. Orbital Tumors -- 17. Primary CNS Lymphoma -- 18. Brain Metastases and Leptomeningeal Metastases -- Part III. Pediatric Neurooncology -- 19. Neurocutaneous Syndromes -- 20. Brainstem Tumors in Children -- 21. Supratentorial Lobar Gliomas in Childhood and Adolescence -- 22. Thalamic Gliomas -- 23. Optic Pathway Gliomas -- 24. Ganglioglioma -- 25. Cerebellar Astrocytomas -- 26. Rare Childhood Tumors: Desmoplastic Infantile Ganglioglioma and Pleomorphic Xanthoastrocytoma -- 27. Ependymoma in the Children -- 28. Medulloblastoma -- 29. Dysembryoplastic Neuroectodermal Tumors -- 30. Craniopharyngioma: Current Classification, Management, and Future Directions -- 31. Intracranial Germ Cell Tumors -- 32. Choroid Plexus Tumors -- 33. Atypical Teratoid Rhabdoid Tumors -- Part IV. Spinal Neurooncology and Peripheral Nerve Tumors -- 34. Intramedullary Tumors -- 35. Intradural Extramedullary Tumors -- 36. Epidural Tumors and Metastases -- 37. Spinal Robotic Radiosurgery -- 38. Peripheral Nerve Sheath Tumors -- Part V. Aspects of General Care in Neurooncology -- 39. Epilepsy and Anticonvulsant Therapy in Brain Tumor Patients -- 40. Hydrocephalus Related to CNS Malignancies in Adults -- 41. Gliomas and Pregnancy -- 42. Delayed Neurologic Complications of Brain Tumor Therapy -- 43. Quality of Life and Cognition -- 44. Palliative Care.
- Format
- e-Book
- Location
- Online
Allergy and Sleep : Basic Principles and Clinical Practice
https://libcat.nshealth.ca/en/permalink/provcat44472
Anna Fishbein, Stephen H. Sheldon, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
Sleep-related abnormalities occurring as a result of allergic disorders can impact an affected individual’s health and overall well-being in a myriad of ways. This comprehensive book thoroughly covers the management of allergic and sleep disorders, providing a detailed discussion on how these co-occurring, often overlapping conditions can be treated in a personalized and patient-oriented manner. Allergy and Sleep: Basic Principles and Clinical Practice takes care to include a wide range of mult…
- Available Online
- View e-Book
- Other Authors
- Fishbein, Anna
- Sheldon, Stephen H.
- Responsibility
- Anna Fishbein, Stephen H. Sheldon, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xv, 463 p.) : 45 illus., 34 illus. in color
- ISBN
- 9783030147389
- 9783030147372 (Print ed.)
- 9783030147396 (Print ed.)
- Subjects (MeSH)
- Comorbidity
- Hypersensitivity - complications
- Sleep Wake Disorders - physiopathology
- Sleep Wake Disorders - therapy
- Abstract
- Sleep-related abnormalities occurring as a result of allergic disorders can impact an affected individual’s health and overall well-being in a myriad of ways. This comprehensive book thoroughly covers the management of allergic and sleep disorders, providing a detailed discussion on how these co-occurring, often overlapping conditions can be treated in a personalized and patient-oriented manner. Allergy and Sleep: Basic Principles and Clinical Practice takes care to include a wide range of multidisciplinary perspectives required to effectively assess and manage allergy and sleep disorders, from allergists, sleep medicine specialists, otolaryngologists, and dermatologists, to primary care physicians, pharmacists, psychologists, and other researchers. Allergy and Sleep begins with a thorough grounding on the science of sleep, allergy, immunology, circadian rhythms and circadian immunology. Part II addresses assessment and treatment of common allergic diseases with comorbid sleep components, in a practical, easy-to-use case-based format. Later sections closely examine sleep-related disturbances commonly associated with asthma, allergic rhinitis, and atopic disease; providing treatment guidelines, and detail various approaches to management throughout the patient’s lifespan. This resource concludes with a review of disease, sleep and circadian-specific therapeutics. Written by experts in their respective fields, Allergy and Sleep: Basic Principles and Clinical Practice is an ideal resource and important reference for any clinician working with patients suffering from sleep-related abnormalities due to allergic disorders.
- Contents
- Part I. Science of Sleep -- 1. Sleep, Sleep Disorders, and Immune Function -- 2. Overview of Basic Immunology -- 3. Overview and Understanding of Basic Circadian Physiology -- 4. Overview and Understanding of Human Circadian Immunology -- 5. Overview and Understanding of Allergic Reactions and Allergic Disease -- 6. Ontogeny of Sleep in Infants, Children, and Adolescents -- Part II. Clinical Science -- 7. Screening for Allergic Disease in a Child with Sleep Disorder and Screening for Sleep Disturbance in Allergic Disease -- 8. Evaluation and Management of a Sleepy Child -- 9. Evaluation and Management of the Sleepless Child -- 10. Evaluation and Management of Movement Disorders in Children -- 11. Evaluation and Management of Allergic Disorders Related to Sleep Pathology -- Part III. Asthma -- 12. Sleep-Related Disturbances Commonly Associated with Asthma -- 13. Obesity, Asthma, and Sleep-Related Breathing Disorders -- 14. Monitoring Asthma During Sleep: Methods and Techniques -- 15. Asthma Treatment Outcome Measures -- 16. Guidelines for Management of Sleep-Related Breathing Disorders and Asthma -- Part IV. Allergic Rhinitis -- 17. Pathophysiology of Sleep-Disordered Breathing and Allergic Rhinitis -- 18. Sleep-Related Breathing Disorders and Inflammation: TNF-a and IL-6 as Prototypic Examples -- 19. Circadian Rhythm of Allergic Rhinitis, Skin Testing and Allergen Immunotherapy -- 20. Differentiating Upper Airways Resistance in Adenoid Hypertrophy, Allergic Rhinitis, and Obstructive Sleep Apnea: Imaging and Approaches -- 21. Allergic Rhinitis and Sleep: Approaches to Management -- Part V. Atopic Dermatitis -- 22. Sleep-Related Disorders Associated with Atopic Dermatitis -- 23. Sleep Disruption in Atopic Dermatitis -- Part VI. Chronic Sinusitis -- 24. Sleep Dysregulation in Chronic Rhinosinusitis -- Part VII. Therapies for Sleep and Sleep-Related Breathing Disorders Associated with Atopic Disease -- 25. Behavioural Management -- 26. Chronotherapy -- 27. Melatonin, Sleep, and Allergy -- 28. Pharmacologic Management of Allergic Disease and Sleep -- 29. Alternative/Integrative Medical Approaches in Allergy and Sleep: Basic Principles and Clinical Practice -- 30. Assessment and Therapies for Sleep and Sleep-Related Breathing Disorders Associated with Atopic Disease in Children: A Dental Perspective -- 31. Surgical Management of Allergic Disease to Treat Sleep Disturbance in Children and Adults -- Appendix: Food Allergy and Sleep.
- Format
- e-Book
- Location
- Online
Using Central Neuromodulators and Psychological Therapies to Manage Patients with Disorders of Gut-Brain Interaction : A Clinical Guide
https://libcat.nshealth.ca/en/permalink/provcat44477
W. Harley Sobin, editor.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This guide provides a concise overview of central neuromodulators and psychological therapies, and their use in managing patients with disorders of gut-brain interaction. The text demonstrates how central neuromodulators can help disordered gut function and reviews choices of drugs for different disorders, along with dosages and recommendations on their use. The book also outlines the use of cognitive behavioral therapy and exposure therapy in treating these patients, and presents a tutorial on…
- Available Online
- View e-Book
- Other Authors
- Sobin, W. Harley
- Responsibility
- W. Harley Sobin, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xiii, 186 p.) : 9 illus., 4 illus. in color
- ISBN
- 9783030182182
- 9783030182175 (Print ed.)
- 9783030182199 (Print ed.)
- Subjects (MeSH)
- Cognitive Behavioral Therapy
- Gastrointestinal Diseases - psychology
- Mind-Body Therapies
- Psychotropic Drugs - therapeutic use
- Specialty
- Gastroenterology
- Psychopharmacology
- Psychotherapy
- Abstract
- This guide provides a concise overview of central neuromodulators and psychological therapies, and their use in managing patients with disorders of gut-brain interaction. The text demonstrates how central neuromodulators can help disordered gut function and reviews choices of drugs for different disorders, along with dosages and recommendations on their use. The book also outlines the use of cognitive behavioral therapy and exposure therapy in treating these patients, and presents a tutorial on how internal medicine physicians should approach the use of psychiatric medications. Written by experts in the field, Using Central Neuromodulators and Psychological Therapies to Manage Patients with Disorders of Gut-Brain Interaction: A Clinical Guide is a valuable resource for clinicians and practitioners on how to treat and manage patients afflicted with disorders of gut-brain interaction.
- Contents
- The Gut-Brain Connection and It’s Significance to Gastroenterologists -- How to Use Central Neuromodulators (CNs) to Help Manage Patients with Disorders of Gut-Brain Interaction (DGBIs) -- A Psychopharmacology Guide by Psychiatrists for Non-Psychiatrists -- Discussion on the Use of Psychiatric Medications, Questions by Harley Sobin MD and Answers by Thomas W. Heinrich -- Cognitive-Behavioral Therapy for Irritable Bowel Syndrome -- Exposure Therapy for Functional GI Disorders -- A Personalized Approach to the Patient Requiring Central Therapies.
- Format
- e-Book
- Location
- Online
Biomarkers in Inflammatory Bowel Diseases
https://libcat.nshealth.ca/en/permalink/provcat44481
Nik Sheng Ding, Peter De Cruz, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, p…
- Available Online
- View e-Book
- Other Authors
- Sheng Ding, Nik
- De Cruz, Peter
- Responsibility
- Nik Sheng Ding, Peter De Cruz, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xvii, 365 p.) : 35 illus., 30 illus. in color
- ISBN
- 9783030114466
- 9783030114459 (Print ed.)
- 9783030114473 (Print ed.)
- Subjects (MeSH)
- Biomarkers
- Inflammatory Bowel Diseases - diagnosis
- Abstract
- This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
- Contents
- 1. Introduction -- Part I. Background to Biomarkers -- 2. Clinical Risk Factors: Lessons from Epidemiology -- 3. Disease Modification in Crohn’s Disease -- 4. Personalized Medicine - Dream or Reality? -- 5. Clinical Trial Design to Facilitate Biomarker Discovery -- Part II. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Crohn’s Disease -- 6. Luminal Crohn’s Disease -- 7. Fibrosis and Stricturing Disease in Crohn’s Disease -- 8. Postoperative Crohn’s Disease -- 9. Perianal Crohn’s Disease -- Part III. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Ulcerative Colitis -- 10. Biomarkers in Acute Severe Ulcerative Colitis -- 11. Chronic Active Ulcerative Colitis -- 12. Refractory Proctitis -- 13. UC Surveillance -- 14. The Role of Biomarkers in the Ileal Anal Pouch -- Part IV. Clinical Algorithms Incorporating Predictive and Prognostic Biomarkers: Specialised Scenarios -- 15. Extra-intestinal Manifestations in Inflammatory Bowel Disease: Diagnosis and Management -- 16. Primary Sclerosing Cholangitis Overlapping with IBD -- 17. Pregnancy and IBD -- 18. Nutrition in IBD -- 19. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Thiopurines -- 20. Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Biologics -- 21. Drug Toxicity: Personalising IBD Therapeutics–The Use of Genetic Biomarkers to Reduce Drug Toxicity -- 22. Biomarkers for Remote Monitoring -- Part V. Scientific Platforms for Biomarker Discovery -- 23. Exposome and Diet -- 24. The Microbiome in IBD -- 25. Metabolic Profiling in IBD -- 26. Innate and Adaptive Immunology -- 27. Genetic and Genomic Markers for Prognostication -- 28. Risk Alleles for Drug Targets: Genomic Markers of Drug Response -- Part VI. Conclusion -- 29. Big Data Meets Real World! The Use of Clinical Informatics in Biomarker Research -- 30. Bringing It Altogether: A Systems Biology Approach to Biomarkers in Inflammatory Bowel Disease.
- Format
- e-Book
- Location
- Online
Digital Health Approach for Predictive, Preventive, Personalised and Participatory Medicine
https://libcat.nshealth.ca/en/permalink/provcat44509
Lotfi Chaari, editor.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This collection, entitled «Digital Health for Predictive, Preventive, Personalized and Participatory Medicine» contains the proceedings of the first International conference on digital health technologies (ICDHT 2018). Ten recent contributions in the fields of Artificial Intelligence (AI) and machine learning, Internet of Things (IoT) and data analysis, all applied to digital health. This collection enables researchers to learn about recent advances in the above mentioned fields. It brings a te…
- Available Online
- View e-Book
- Other Authors
- Chaari, Lotfi
- Responsibility
- Lotfi Chaari, editor
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (xvi, 88 p.) : 35 illus., 23 illus. in color
- Series Vol.
- v. 10
- ISBN
- 9783030118006
- 9783030117993 (Print ed.)
- 9783030118013 (Print ed.)
- ISSN
- 2211-3495
- Subjects (MeSH)
- Medical Informatics Applications
- Precision Medicine
- Specialty
- Medical Informatics
- Telemedicine
- Abstract
- This collection, entitled «Digital Health for Predictive, Preventive, Personalized and Participatory Medicine» contains the proceedings of the first International conference on digital health technologies (ICDHT 2018). Ten recent contributions in the fields of Artificial Intelligence (AI) and machine learning, Internet of Things (IoT) and data analysis, all applied to digital health. This collection enables researchers to learn about recent advances in the above mentioned fields. It brings a technological viewpoint of P4 medicine. Readers will discover how advanced Information Technology (IT) tools can be used for healthcare. For instance, the use of connected objects to monitor physiological parameters is discussed. Moreover, even if compressed sensing is nowadays a common acquisition technique, its use for IoT is presented in this collection through one of the pioneer works in the field. In addition, the use of AI for epileptic seizure detection is also discussed as being one of the major concerns of predictive medicine both in industrialized and low-income countries. This work is edited by Prof. Lotfi Chaari, professor at the University of Sfax, and previously at the University of Toulouse. This work comes after more than ten years of expertise in the biomedical signal and image processing field.
- Contents
- Seizure Onset Detection in EEG Signals Based on Entropy from Generalized Gaussian PDF Modeling and Ensemble Bagging Classifier -- Artificial Neuroplasticity with Deep Learning Reconstruction Signals to Reconnect Motion Signals for the Spinal Cord -- Improved Massive MIMO Cylindrical Adaptive Antenna Array -- Mulitifractal Analysis with Lacunarity for Microcalcification Segmentation -- Consolidated Clinical Document Architecture: Analysis and Evaluation to Support the Interoperability of Tunisian Health Systems - Bayesian Compressed Sensing for IoT: Application to EEG Recording -- Patients Stratification in Imbalanced Datasets: A Roadmap -- Real-Time Driver Fatigue Monitoring with a Dynamic Bayesian Network Model -- Epileptic Seizure Detection Using a Convolutional Neural Network.
- Format
- e-Book
- Publication Type
- Congress
- Location
- Online
Precision Medicine in Cancer Therapy
https://libcat.nshealth.ca/en/permalink/provcat44534
Daniel D. Von Hoff, Haiyong Han, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailore…
- Available Online
- View e-Book
- Other Authors
- Von Hoff, Daniel D.
- Han, Haiyong
- Responsibility
- Daniel D. Von Hoff, Haiyong Han, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (x, 283 p.)
- Series Vol.
- v. 178
- Series Title
- Cancer treatment and research
- ISBN
- 9783030163914
- 9783030163907 (Print ed.)
- 9783030163921 (Print ed.)
- 9783030163938 (Print ed.)
- ISSN
- 0927-3042
- Subjects (MeSH)
- Genetic Techniques
- Neoplasms - drug therapy
- Precision Medicine - methods
- Specialty
- Medical Oncology
- Precision Medicine
- Abstract
- This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care.
- Contents
- Part I. Individual Types of Cancer Precision Medicine -- 1. Targeted Therapies in Non-small-Cell Lung Cancer -- 2. Update on Precision Medicine in Breast Cancer -- 3. The Role of Precision Medicine in the Diagnosis and Treatment of Patients with Rare Cancers -- Part II. Currently Available Techniques -- 4. Immunohistochemistry-Enabled Precision Medicine -- 5. Genomics-Enabled Precision Medicine for Cancer -- 6. Utilization of Proteomic Technologies for Precision Oncology Applications -- 7. Precision Medicine-Enabled Cancer Immunotherapy -- Part III. Future Precision Medicine -- 8. Use of Precision Imaging in the Evaluation of Pancreas Cancer -- 9. Single-Cell Sequencing in Precision Medicine -- 10. Human Microbiota and Personalized Cancer Treatments: Role of Commensal Microbes in Treatment Outcomes for Cancer Patients -- 11. Artificial Intelligence and Personalized Medicine.
- Format
- e-Book
- Location
- Online
Targeted Therapies in Lung Cancer : Management Strategies for Nurses and Practitioners
https://libcat.nshealth.ca/en/permalink/provcat44628
Marianne Davies, Beth Eaby-Sandy, editors.
--Cham:
Springer
, c2019.
- Available Online
- View e-Book
- Location
- Online
This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that…
- Available Online
- View e-Book
- Other Authors
- Davies, Marianne
- Eaby-Sandy, Beth
- Responsibility
- Marianne Davies, Beth Eaby-Sandy, editors
- Place of Publication
- Cham
- Publisher
- Springer
- Date of Publication
- c2019
- Physical Description
- 1 online resource (v, 120 p.) : 9 illus., 8 illus. in color
- ISBN
- 9783030165505
- 9783030165499 (Print ed.)
- 9783030165512 (Print ed.)
- 9783030165529 (Print ed.)
- Abstract
- This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK, ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.
- Contents
- 1. Introduction - 2. Introduction to Mutation Testing -- 3. Nursing Considerations with EGFR Inhibitors in NSCLC -- 4. Nursing Considerations with ALK and ROS1 Inhibitors in NSCLC -- 5. BRAF in NSCLC -- 6. Mechanisms of Acquired Resistance to Targeted Therapy in NSCLC: Role of Repeat Biopsy and Nursing Considerations -- 7. The Impact and Toxicity of Checkpoint Inhibitors in Management of Lung Cancer -- 8. The Role of Anti-Angiogenic Agents (VEGF) -- 9. Nursing Considerations for Patients Treated with Targeted Therapies.
- Format
- e-Book
- Publication Type
- Nurses' Instruction
- Location
- Online
Pulmonary pathology
https://libcat.nshealth.ca/en/permalink/provcat31501
edited by Dani S. Zander, Carol F. Farver.
(2nd ed.)
--Philadelphia, PA:
Elsevier
, c2018.
- Available Online
- View e-Book
- Access
- Registration required for PDF access.
- Location
- Online
Now fully revised to include recent advances in the field, the second edition of Pulmonary Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what’s new in pulmonary pathology and pulmonary medicine, including molecular genetics and personalized medicine therapies. Practical and affordable, this resource is ideal for s…
- Available Online
- View e-Book
- Other Authors
- Zander, Dani S
- Farver, Carol F
- Responsibility
- edited by Dani S. Zander, Carol F. Farver
- Edition
- 2nd ed.
- Place of Publication
- Philadelphia, PA
- Publisher
- Elsevier
- Date of Publication
- c2018
- Physical Description
- 1 online resource, 776 p.
- Series Title
- Foundations in diagnostic pathology
- ISBN
- 9780323393089 (electronic bk.)
- Subjects (MeSH)
- Lung Diseases - diagnosis
- Lung Diseases - pathology
- Pleural Diseases - diagnosis
- Pleural Diseases - pathology
- Subjects (LCSH)
- Lungs - Pathophysiology
- Lungs - Diseases - Diagnosis
- Lung Diseases - diagnosis
- Lung Diseases - pathology
- Pleural Diseases - diagnosis
- Pleural Diseases - pathology
- Specialty
- Pathology
- Pulmonary Medicine
- Abstract
- Now fully revised to include recent advances in the field, the second edition of Pulmonary Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what’s new in pulmonary pathology and pulmonary medicine, including molecular genetics and personalized medicine therapies. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.
- Access
- Registration required for PDF access.
- Format
- e-Book
- Location
- Online
